-- dump date 20140619_051148 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 257309000001 SEQ_END SEQ_END NC_002935.2 2488635 2488635 DR NC_002935.2; contig end 2488635..2488635 Corynebacterium diphtheriae NCTC 13129 NP_938410.1 CDS dnaA NC_002935.2 19 1677 D binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosome replication initiator DnaA 19..1677 Corynebacterium diphtheriae NCTC 13129 2650569 NP_938411.2 CDS dnaN NC_002935.2 2316 3503 D binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 2316..3503 Corynebacterium diphtheriae NCTC 13129 2649984 NP_938412.1 CDS recF NC_002935.2 3542 4735 D Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 3542..4735 Corynebacterium diphtheriae NCTC 13129 2650258 NP_938413.1 CDS DIP0004 NC_002935.2 4725 5276 D Similar to Mycobacterium paratuberculosis hypothetical 17.5 kDa protein TR:Q9L7L4 (EMBL:AF222789) (166 aa) fasta scores: E(): 5.6e-18, 45.45% id in 143 aa; hypothetical protein 4725..5276 Corynebacterium diphtheriae NCTC 13129 2650606 NP_938414.1 CDS gyrB NC_002935.2 5379 7436 D negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 5379..7436 Corynebacterium diphtheriae NCTC 13129 2650607 NP_938415.1 CDS DIP0006 NC_002935.2 7503 7940 R Doubtful CDS. No significant database matches; hypothetical protein complement(7503..7940) Corynebacterium diphtheriae NCTC 13129 2648824 NP_938416.1 CDS DIP0007 NC_002935.2 8201 8473 R Doubtful CDS. No significant database matches; hypothetical protein complement(8201..8473) Corynebacterium diphtheriae NCTC 13129 2648825 NP_938417.1 CDS DIP0008 NC_002935.2 8478 8681 R Similar to Streptomyces coelicolor hypothetical 7.1 kDa protein SC10A5.13 TR:O54104 (EMBL:AL021529) (64 aa) fasta scores: E(): 0.18, 52.5% id in 40 aa; hypothetical protein complement(8478..8681) Corynebacterium diphtheriae NCTC 13129 2648826 NP_938418.1 CDS gyrA NC_002935.2 8792 11362 D negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 8792..11362 Corynebacterium diphtheriae NCTC 13129 2648827 NP_938419.1 CDS DIP0010 NC_002935.2 11362 11706 D Similar in its C-terminal region to Mycobacterium leprae hypothetical 32.2 kDa protein MLB1770.07 or ML0007 TR:O32870 (EMBL:Z70722) (303 aa) fasta scores: E(): 9.9e-08, 36.28% id in 113 aa; hypothetical protein 11362..11706 Corynebacterium diphtheriae NCTC 13129 2650417 NP_938420.1 CDS DIP0011 NC_002935.2 12176 12904 R Similar to Escherichia coli glc operon transcriptional activator GlcC or B2980 SW:GLCC_ECOLI (P52072) (254 aa) fasta scores: E(): 1.2e-05, 23.5% id in 234 aa; regulatory protein complement(12176..12904) Corynebacterium diphtheriae NCTC 13129 2650420 NP_938421.1 CDS lldP NC_002935.2 12992 14662 R Similar to Escherichia coli L-lactate permease LldP or LctP or B3603 SW:LLDP_ECOLI (P33231) (551 aa) fasta scores: E(): 2.4e-68, 40.1% id in 561 aa; L-lactate permease complement(12992..14662) Corynebacterium diphtheriae NCTC 13129 2648748 NP_938422.1 CDS DIP0013 NC_002935.2 15159 15632 D hypothetical protein 15159..15632 Corynebacterium diphtheriae NCTC 13129 2648555 NP_938423.1 CDS DIP0014 NC_002935.2 15721 17364 D Low similarity to Staphylococcus aureus subsp aureus N315 SA0639 protein TR:Q99VT7 (EMBL:AP003131) (543 aa) fasta scores: E(): 3e-23, 25.56% id in 485 aa; hypothetical protein 15721..17364 Corynebacterium diphtheriae NCTC 13129 2648556 NP_938424.1 CDS DIP0015 NC_002935.2 17354 19000 D Similar to Escherichia coli, and Escherichia coli O157:H7 probable transport ATP-binding protein MsbA or B0914 or Z1260 or ECS0997 SWALL:MSBA_ECOLI (SWALL:P27299) (582 aa) fasta scores: E(): 7e-30, 26.73% id in 561 aa, and to Pasteurella multocida hypothetical protein PM1473 TR:Q9CKX8 (EMBL:AE006183) (552 aa) fasta scores: E(): 6.1e-33, 27.97% id in 554 aa; transport system, ATP-binding protein 17354..19000 Corynebacterium diphtheriae NCTC 13129 2649060 NP_938425.1 CDS DIP0016 NC_002935.2 <19447 19767 D No database matches. Possible membrane protein; hypothetical protein <19447..19767 Corynebacterium diphtheriae NCTC 13129 2650598 NP_938426.1 CDS DIP0017 NC_002935.2 19865 20029 D Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 19865..20029 Corynebacterium diphtheriae NCTC 13129 2650599 NP_938427.1 CDS DIP0018 NC_002935.2 20524 20721 D Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 20524..20721 Corynebacterium diphtheriae NCTC 13129 2650601 NP_938428.1 CDS DIP0019 NC_002935.2 20713 20958 R Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein complement(20713..20958) Corynebacterium diphtheriae NCTC 13129 2650602 NP_938429.1 CDS DIP0020 NC_002935.2 20955 21185 R Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein complement(20955..21185) Corynebacterium diphtheriae NCTC 13129 2650603 NP_938430.1 CDS DIP0021 NC_002935.2 21381 22379 D Similar to Streptomyces coelicolor probable solute-binding lipoprotein SC8F11.05 TR:Q9KZH3 (EMBL:AL353864) (340 aa) fasta scores: E(): 2.8e-63, 54.98% id in 331 aa; solute-binding lipoprotein 21381..22379 Corynebacterium diphtheriae NCTC 13129 2650604 NP_938431.1 CDS DIP0022 NC_002935.2 22376 23407 D Similar to Streptomyces coelicolor probable ABC transport protein, membrane component SC8F11.06 TR:Q9KZH2 (EMBL:AL353864) (359 aa) fasta scores: E(): 1.1e-72, 57.66% id in 326 aa; ABC transporter 22376..23407 Corynebacterium diphtheriae NCTC 13129 2650605 NP_938432.1 CDS DIP0023 NC_002935.2 23408 24169 D Similar to Streptomyces coelicolor probable ABC transport protein, ATP-binding component SC8F11.07 TR:Q9KZH1 (EMBL:AL353864) (330 aa) fasta scores: E(): 2.8e-51, 62.15% id in 251 aa; ABC transporter ATP-binding protein 23408..24169 Corynebacterium diphtheriae NCTC 13129 2648749 NP_938433.1 CDS DIP0024 NC_002935.2 24217 24825 R Possible membrane protein. No database matches; hypothetical protein complement(24217..24825) Corynebacterium diphtheriae NCTC 13129 2648750 NP_938434.1 CDS ppiA NC_002935.2 24888 25430 D Similar to Mycobacterium tuberculosis probable peptidyl-prolyl cis-trans isomerase A PpiA or Rv0009 or MT0011 or MTCY10H4.08 SW:PPIA_MYCTU (P71578) (182 aa) fasta scores: E(): 4.7e-52, 78.36% id in 171 aa; peptidyl-prolyl cis-trans isomerase A 24888..25430 Corynebacterium diphtheriae NCTC 13129 2648751 NP_938435.1 CDS DIP0026 NC_002935.2 25519 >25752 R Similar to Streptococcus mutans transposase (fragment) TR:Q9ZHF4 (EMBL:AF065413) (75 aa) fasta scores: E(): 3.5e-11, 47.22% id in 72 aa; transposase (partial) complement(25519..>25752) Corynebacterium diphtheriae NCTC 13129 2650199 NP_938436.1 CDS DIP0027 NC_002935.2 25877 26494 D Similar to Mycobacterium tuberculosis transmembrane protein Rv0110 or MTV031.04 TR:O53632 (EMBL:AL021926) (249 aa) fasta scores: E(): 1.4e-13, 34.19% id in 193 aa; hypothetical protein 25877..26494 Corynebacterium diphtheriae NCTC 13129 2650611 NP_938437.1 CDS DIP0028 NC_002935.2 26672 27025 R hypothetical protein complement(26672..27025) Corynebacterium diphtheriae NCTC 13129 2650612 NP_938438.1 CDS thiC NC_002935.2 27567 29366 D required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC 27567..29366 Corynebacterium diphtheriae NCTC 13129 2650613 NP_938439.1 CDS thiE NC_002935.2 29350 30018 D Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate; thiamine-phosphate pyrophosphorylase 29350..30018 Corynebacterium diphtheriae NCTC 13129 2650614 NP_938440.1 CDS thiO NC_002935.2 30015 31103 D Similar to Rhizobium etli thiamine biosynthesis oxidoreductase ThiO SW:THIO_RHIET (O34292) (327 aa) fasta scores: E(): 5.4e-09, 31.67% id in 341 aa; thiamine biosynthesis oxidoreductase 30015..31103 Corynebacterium diphtheriae NCTC 13129 2650615 NP_938441.1 CDS DIP0032 NC_002935.2 31087 31287 D Similar to Streptomyces coelicolor hypothetical 6.6 kDa protein SC6E10.02 TR:Q9S2N5 (EMBL:AL109661) (66 aa) fasta scores: E(): 1.1e-06, 36.36% id in 66 aa; hypothetical protein 31087..31287 Corynebacterium diphtheriae NCTC 13129 2650184 NP_938442.1 CDS thiG NC_002935.2 31289 32074 D functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase 31289..32074 Corynebacterium diphtheriae NCTC 13129 2650185 NP_938443.1 CDS DIP0034 NC_002935.2 32071 33084 D catalyzes the adenylation of ThiS which is involved in the formation of 5-methyl-4-(beta-hydroxyethyl)thiazole phosphate; thiamine biosynthesis protein ThiF 32071..33084 Corynebacterium diphtheriae NCTC 13129 2650186 NP_938444.1 CDS thiD NC_002935.2 33081 33899 D Similar to Escherichia coli phosphomethylpyrimidine kinase ThiD or B2103 SW:THID_ECOLI (P76422) (266 aa) fasta scores: E(): 5.5e-30, 44.9% id in 265 aa; phosphomethylpyrimidine kinase 33081..33899 Corynebacterium diphtheriae NCTC 13129 2650187 NP_938445.1 CDS DIP0036 NC_002935.2 34478 37732 D Similar in its N-terminal region to Pasteurella multocida hypothetical protein PM1127 TR:Q9CLT2 (EMBL:AE006153) (1056 aa) fasta scores: E(): 1.4e-15, 21.94% id in 802 aa; hypothetical protein 34478..37732 Corynebacterium diphtheriae NCTC 13129 2650188 NP_938446.1 CDS DIP0037 NC_002935.2 37736 38650 D Similar to Neisseria meningitidis hypothetical protein NMA0630 TR:Q9JVY0 (EMBL:AL162753) (304 aa) fasta scores: E(): 2.7e-22, 37.5% id in 256 aa, and to Pasteurella multocida hypothetical protein PM1126 TR:Q9CLT3 (EMBL:AE006153) (343 aa) fasta scores: E(): 3.5e-22, 32.04% id in 284 aa; hypothetical protein 37736..38650 Corynebacterium diphtheriae NCTC 13129 2650439 NP_938447.1 CDS DIP0038 NC_002935.2 38634 38963 D Similar to Pasteurella multocida hypothetical protein PM1125 TR:Q9CLT4 (EMBL:AE006153) (108 aa) fasta scores: E(): 9.3e-07, 42.85% id in 77 aa; hypothetical protein 38634..38963 Corynebacterium diphtheriae NCTC 13129 2650440 NP_938448.1 CDS DIP0039 NC_002935.2 38967 39077 R Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein complement(38967..39077) Corynebacterium diphtheriae NCTC 13129 2650441 NP_938449.1 CDS DIP0040 NC_002935.2 39311 39592 R Similar to the C-terminal region of Rickettsia prowazekii hypothetical protein RP756 SW:Y756_RICPR (Q9ZCI4) (105 aa) fasta scores: E(): 3.4, 33.33% id in 51 aa; hypothetical protein complement(39311..39592) Corynebacterium diphtheriae NCTC 13129 2650442 NP_938450.1 CDS DIP0046 NC_002935.2 40822 40923 R Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein complement(40822..40923) Corynebacterium diphtheriae NCTC 13129 2648893 NP_938451.1 CDS DIP0047 NC_002935.2 41066 42614 R Similar to Mycobacterium smegmatis transposase TR:O70063 (EMBL:AF036759) (503 aa) fasta scores: E(): 4.7e-88, 50% id in 498 aa. Presents a frameshift at residue 65; transposase complement(join(41066..42397,42420..42614)) Corynebacterium diphtheriae NCTC 13129 2648894 NP_938452.1 CDS DIP0049 NC_002935.2 <42736 42969 D Similar to Corynebacterium jeikeium transposase B TnpB TR:AAK67710 (EMBL:AY036070) (302 aa) fasta scores: E(): 1.2e-06, 45.45% id in 55 aa, and to Escherichia coli O157:H7 EDL933 partial transposase Z1207 TR:AAG55352 (EMBL:AE005276) (82 aa) fasta scores: E(): 5.2e-05, 38% id in 50 aa; transposase (partial) <42736..42969 Corynebacterium diphtheriae NCTC 13129 2648895 NP_938453.1 CDS DIP0050 NC_002935.2 43101 43196 D Doubtful CDS. No significant database matches; hypothetical protein 43101..43196 Corynebacterium diphtheriae NCTC 13129 2648896 NP_938454.1 CDS DIP0051 NC_002935.2 43189 43284 D Doubtful CDS. No significant database matches; hypothetical protein 43189..43284 Corynebacterium diphtheriae NCTC 13129 2648897 NP_938455.1 CDS DIP0052 NC_002935.2 43308 43577 R integral membrane protein involved in inhibition of the Z-ring formation; septation inhibitor protein complement(43308..43577) Corynebacterium diphtheriae NCTC 13129 2648898 NP_938456.1 CDS pknB NC_002935.2 43694 45715 R Similar to Mycobacterium leprae probable serine/threonine-protein kinase PknB or ML0016 SW:PKNB_MYCLE (P54744) (622 aa) fasta scores: E(): 5.7e-58, 43.26% id in 661 aa; serine/threonine-protein kinase complement(43694..45715) Corynebacterium diphtheriae NCTC 13129 2648899 NP_938457.1 CDS pknA NC_002935.2 45712 47217 R Similar to Mycobacterium leprae probable serine/threonine-protein kinase PnkA or ML0017 SW:PKNA_MYCLE (P54743) (437 aa) fasta scores: E(): 4e-37, 41.99% id in 431 aa; serine/threonine-protein kinase complement(45712..47217) Corynebacterium diphtheriae NCTC 13129 2649543 NP_938458.1 CDS pbpA NC_002935.2 47230 48690 R Similar to Mycobacterium leprae penicillin-binding protein PbpA or ML0018 TR:Q9CDE6 (EMBL:AL583917) (492 aa) fasta scores: E(): 1.3e-72, 45.9% id in 488 aa; secreted penicillin-binding protein complement(47230..48690) Corynebacterium diphtheriae NCTC 13129 2650426 NP_938459.1 CDS ftsW NC_002935.2 48687 50036 R Similar to Mycobacterium tuberculosis probable cell division protein FtsW or Rv0017c or MT0020 or MTCY10H4.17c SW:FTSW_MYCTU (P71587) (469 aa) fasta scores: E(): 8.7e-72, 48.61% id in 434 aa, and to Escherichia coli rod shape-determining protein MrdB or RodA or B0634 or Z0780 or ECS0672 SW:RODA_ECOLI (P15035) (370 aa) fasta scores: E(): 8.5e-19, 26.57% id in 365 aa; cell division protein complement(48687..50036) Corynebacterium diphtheriae NCTC 13129 2650427 NP_938460.1 CDS DIP0057 NC_002935.2 50037 51494 R Similar to Mycobacterium leprae probable phosphoprotein phosphatase Ppp TR:Q50188 (EMBL:Z70722) (509 aa) fasta scores: E(): 5.8e-46, 43.64% id in 488 aa; phosphoprotein phosphatase complement(50037..51494) Corynebacterium diphtheriae NCTC 13129 2650428 NP_938461.1 CDS DIP0058 NC_002935.2 51491 51979 R Similar to Mycobacterium leprae hypothetical 17.2 kDa protein MLB1770.14c or ML0021 TR:Q50189 (EMBL:Z70722) (155 aa) fasta scores: E(): 2.3e-13, 35% id in 160 aa; hypothetical protein complement(51491..51979) Corynebacterium diphtheriae NCTC 13129 2650564 NP_938462.1 CDS DIP0059 NC_002935.2 51993 52859 R Similar to Streptomyces coelicolor hypothetical 30.8 kDa protein SCH69.13 TR:Q9XA21 (EMBL:AL079308) (290 aa) fasta scores: E(): 3.1e-11, 27.6% id in 297 aa; hypothetical protein complement(51993..52859) Corynebacterium diphtheriae NCTC 13129 2650565 NP_938463.1 CDS DIP0061 NC_002935.2 53813 56047 R Similar to Enterococcus hirae probable copper exporting ATPase B CopB SW:COPB_ENTHR (P05425) (745 aa) fasta scores: E(): 2.2e-94, 43.228% id in 731 aa, and to Mycobacterium tuberculosis probable cation-transporting ATPase V CtpV or Rv0969 or MT0997 or MTCY10D7.05c SW:CTPV_MYCTU (P77894) (770 aa) fasta scores: E(): 2e-69, 40.092% id in 651 aa; cation-transporting ATPase complement(53813..56047) Corynebacterium diphtheriae NCTC 13129 2650568 NP_938464.1 CDS DIP0062 NC_002935.2 56099 56425 R Similar to Deinococcus radiodurans conserved hypothetical protein DR2452 TR:Q9RRN6 (EMBL:AE002074) (68 aa) fasta scores: E(): 0.0038, 43.103% id in 58 aa, and to Streptococcus pyogenes copper chaperone-copper transport operon CopZ or SPY1714 TR:Q99YG6 (EMBL:AE006600) (67 aa) fasta scores: E(): 0.0065, 40.000% id in 60 aa, and to Pseudomonas syringae Plasmid pPaCu1 copper resistance operon ORFH protein TR:Q9KWM7 (EMBL:AB033420) (65 aa) fasta scores: E(): 0.025, 40.000% id in 60 aa, and to Candida albicans copper-transporting p-type ATPase Ccc2 TR:AAK52331 (EMBL:AY033084) (1204 aa) fasta scores: E(): 0.03, 28.571% id in 84 aa; heavy metal-associated transport protein complement(56099..56425) Corynebacterium diphtheriae NCTC 13129 2649058 NP_938465.1 CDS DIP0063 NC_002935.2 56540 57667 R Similar to Escherichia coli sensor protein BaeS or B2078 SW:BAES_ECOLI (P30847) (467 aa) fasta scores: E(): 1.8e-28, 33.333% id in 372 aa; two-component system sensor protein complement(56540..57667) Corynebacterium diphtheriae NCTC 13129 2649059 NP_938466.1 CDS DIP0064 NC_002935.2 57664 58386 R Similar to Enterococcus faecalis VicR protein TR:Q9REA7 (EMBL:AJ012050) (283 aa) fasta scores: E(): 5.5e-35, 44.978% id in 229 aa, to Bacillus subtilis alkaline phosphatase synthesis transcriptional regulatory protein PhoP SW:PHOP_BACSU (P13792) (240 aa) fasta scores: E(): 3e-34, 42.918% id in 233 aa, and to Bacillus subtilis hypothetical sensory transduction protein YycF SW:YYCF_BACSU (P37478) (235 aa) fasta scores: E(): 1.8e-33, 43.478% id in 230 aa; two-component system response regulator complement(57664..58386) Corynebacterium diphtheriae NCTC 13129 2650608 NP_938467.1 CDS DIP0066 NC_002935.2 58730 59365 D No database matches; hypothetical protein 58730..59365 Corynebacterium diphtheriae NCTC 13129 2650609 NP_938468.1 CDS DIP0067 NC_002935.2 59436 60917 D Similar to Mycobacterium tuberculosis CDC1551 copper-binding protein, MT0869 TR:AAK45112 (EMBL:AE006975) (504 aa) fasta scores: E(): 9e-68, 43.028% id in 502 aa, and to Nicotiana tabacum L-ascorbate oxidase precursor Aao SW:ASO_TOBAC (Q40588) (578 aa) fasta scores: E(): 2.5e-14, 25.344% id in 509 aa. Note: Contains a twin-arginine translocation (TAT) system recognition motif (RRQFLL) at the N-terminal region; exported multicopper oxidase 59436..60917 Corynebacterium diphtheriae NCTC 13129 2650610 NP_938469.1 CDS DIP0068 NC_002935.2 60895 61203 R Weak similarities to Streptomyces coelicolor DNA polymerase III, epsilon chain SCI8.12 TR:Q9RJ41 (EMBL:AL132644) (328 aa) fasta scores: E(): 2.7, 42.22% id in 45 aa, and to Thermotoga maritima DNA polymerase III PolC-type PolC or TM0576 SW:DPO3_THEMA (Q9ZHF6) (1367 aa) fasta scores: E(): 9.3, 39.58% id in 48 aa; hypothetical protein complement(60895..61203) Corynebacterium diphtheriae NCTC 13129 2649666 NP_938470.1 CDS DIP0071 NC_002935.2 62898 63353 R hypothetical protein complement(62898..63353) Corynebacterium diphtheriae NCTC 13129 2649668 NP_938471.1 CDS DIP0072 NC_002935.2 63350 63850 R hypothetical protein complement(63350..63850) Corynebacterium diphtheriae NCTC 13129 2649669 NP_938472.1 CDS DIP0073 NC_002935.2 63823 64218 R Weakly similar to Rhizobium loti MLR2640 protein TR:Q98HZ4 (EMBL:AP003000) (140 aa) fasta scores: E(): 4.2, 27.1% id in 107 aa; Conserved hypothetical protein; hypothetical protein complement(63823..64218) Corynebacterium diphtheriae NCTC 13129 2649670 NP_938473.1 CDS DIP0074 NC_002935.2 64253 64393 R Doubtful CDS. No significant database matches; hypothetical protein complement(64253..64393) Corynebacterium diphtheriae NCTC 13129 2649671 NP_938474.1 CDS DIP0075 NC_002935.2 64602 66083 D hypothetical protein 64602..66083 Corynebacterium diphtheriae NCTC 13129 2649672 NP_938475.1 CDS DIP0076 NC_002935.2 66426 66797 D hypothetical protein 66426..66797 Corynebacterium diphtheriae NCTC 13129 2649673 NP_938476.1 CDS DIP0077 NC_002935.2 66921 67721 D hypothetical protein 66921..67721 Corynebacterium diphtheriae NCTC 13129 2650189 NP_938477.1 CDS DIP0078 NC_002935.2 67740 68582 D hypothetical protein 67740..68582 Corynebacterium diphtheriae NCTC 13129 2650190 NP_938478.1 CDS DIP0079 NC_002935.2 68563 69828 D hypothetical protein 68563..69828 Corynebacterium diphtheriae NCTC 13129 2650191 NP_938479.1 CDS DIP0080 NC_002935.2 69994 70125 D Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 69994..70125 Corynebacterium diphtheriae NCTC 13129 2650192 NP_938480.1 CDS DIP0081 NC_002935.2 70294 70473 D Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 70294..70473 Corynebacterium diphtheriae NCTC 13129 2650193 NP_938481.1 CDS DIP0082 NC_002935.2 70504 70929 D Possible secreted protein. No database matches; hypothetical protein 70504..70929 Corynebacterium diphtheriae NCTC 13129 2650194 NP_938482.1 CDS DIP0083 NC_002935.2 70997 71137 D Doubtful CDS. No significant database matches; hypothetical protein 70997..71137 Corynebacterium diphtheriae NCTC 13129 2650195 NP_938483.1 CDS DIP0084 NC_002935.2 71572 71700 D Doubtful CDS. Possible membrane protein. No database matches; hypothetical protein 71572..71700 Corynebacterium diphtheriae NCTC 13129 2650196 NP_938484.1 CDS DIP0085 NC_002935.2 71845 72360 R Weakly similar to Euhadra herklotsi NADH dehydrogenase subunit 1 TR:O21342 (EMBL:Z71695) (296 aa) fasta scores: E(): 0.57, 24.16% id in 120 aa; hypothetical protein complement(71845..72360) Corynebacterium diphtheriae NCTC 13129 2650197 NP_938485.1 CDS DIP0086 NC_002935.2 72365 72664 R Similar to Deinococcus radiodurans transcriptional regulator, HTH_3 family DR2259 TR:Q9RS68 (EMBL:AE002058) (82 aa) fasta scores: E(): 1.3e-10, 47.67% id in 86 aa; regulatory protein complement(72365..72664) Corynebacterium diphtheriae NCTC 13129 2650198 NP_938486.1 CDS DIP0089 NC_002935.2 73648 74943 R Weakly similar in its N-terminal region to Bacillus subtilis SpaE TR:O52853 (EMBL:U09819) (251 aa) fasta scores: E(): 0.0095, 21% id in 200 aa; hypothetical protein complement(73648..74943) Corynebacterium diphtheriae NCTC 13129 2649540 NP_938487.1 CDS DIP0090 NC_002935.2 75080 75781 R Similar to Lactococcus lactis NisF TR:Q48597 (EMBL:U17255) (225 aa) fasta scores: E(): 1.3e-25, 43.8% id in 226 aa, and to Staphylococcus epidermidis ABC transporter subunit EpiF TR:Q54002 (EMBL:U77778) (231 aa) fasta scores: E(): 7.1e-21, 38.15% id in 228 aa; ABC transporter ATP-binding protein complement(75080..75781) Corynebacterium diphtheriae NCTC 13129 2649541 NP_938488.1 CDS DIP0091 NC_002935.2 75820 76479 R Similar to Streptomyces lividans response regulator homolog TR:P72471 (EMBL:U63847) (225 aa) fasta scores: E(): 2.7e-29, 42.98% id in 221 aa, and to Streptomyces coelicolor two-component system regulator SCH10.18c TR:Q9X8Q7 (EMBL:AL049754) (228 aa) fasta scores: E(): 3e-26, 38.53% id in 218 aa; two-component system response regulator complement(75820..76479) Corynebacterium diphtheriae NCTC 13129 2649542 NP_938489.1 CDS DIP0092 NC_002935.2 76479 77708 R Similar to Streptomyces coelicolor two component sensor kinase SC5F7.35c TR:Q9S2S0 (EMBL:AL096872) (416 aa) fasta scores: E(): 2.9e-17, 32.79% id in 308 aa, and to Streptomyces coelicolor two-component system sensor kinase SCH10.17c TR:Q9X8Q6 (EMBL:AL049754) (472 aa) fasta scores: E(): 1.1e-11, 33.61% id in 241 aa; two component system sensor kinase complement(76479..77708) Corynebacterium diphtheriae NCTC 13129 2648506 NP_938490.1 CDS DIP0093 NC_002935.2 77804 78145 R Probable membrane protein. No database matches; hypothetical protein complement(77804..78145) Corynebacterium diphtheriae NCTC 13129 2650560 NP_938491.1 CDS DIP0094 NC_002935.2 78214 78330 R Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein complement(78214..78330) Corynebacterium diphtheriae NCTC 13129 2650561 NP_938492.1 CDS opuBB NC_002935.2 78414 79088 R Similar to Bacillus subtilis choline transport system permease OpuBB or ProW SW:OPBB_BACSU (Q45461) (217 aa) fasta scores: E(): 3e-14, 30.72% id in 192 aa, and to Mycobacterium tuberculosis transport system permease Rv3756c or MTV025.104c TR:O69722 (EMBL:AL022121) (239 aa) fasta scores: E(): 1.9e-28, 48.32% id in 209 aa; choline transport system permease complement(78414..79088) Corynebacterium diphtheriae NCTC 13129 2650562 NP_938493.1 CDS opuBD NC_002935.2 79095 79736 R Similar to Bacillus subtilis choline transport system permease OpuBD or ProZ SW:OPBD_BACSU (P39775) (226 aa) fasta scores: E(): 8.5e-13, 29.44% id in 197 aa, and to Mycobacterium tuberculosis transport system permease Rv3757c or MTV025.105c TR:O69723 (EMBL:AL022121) (229 aa) fasta scores: E(): 4.7e-25, 39.71% id in 209 aa; choline transport system permease complement(79095..79736) Corynebacterium diphtheriae NCTC 13129 2650563 NP_938494.1 CDS opuBA NC_002935.2 79727 80557 R Similar to Bacillus subtilis choline transport ATP-binding protein OpuBA or ProV SW:OPBA_BACSU (Q45460) (381 aa) fasta scores: E(): 2.5e-42, 50.58% id in 255 aa, and to Mycobacterium tuberculosis ABC transporter ATP-binding protein Rv3758c or MTV025.106c TR:O69724 (EMBL:AL022121) (376 aa) fasta scores: E(): 1.3e-42, 53.62% id in 248 aa; choline transport system ATP-binding protein complement(79727..80557) Corynebacterium diphtheriae NCTC 13129 2648515 NP_938495.1 CDS DIP0098 NC_002935.2 80567 81175 R Weakly similar to Mycobacterium tuberculosis hypothetical 23.9 kDa protein Rv0444c or MTV037.08C TR:O53729 (EMBL:AL021932) (232 aa) fasta scores: E(): 0.004, 25.94% id in 212 aa; hypothetical protein complement(80567..81175) Corynebacterium diphtheriae NCTC 13129 2648516 NP_938496.1 CDS DIP0099 NC_002935.2 81172 81756 R Similar to Streptomyces coelicolor RNA polymerase sigma factor SCI11.12c TR:Q9S2A7 (EMBL:AL096849) (185 aa) fasta scores: E(): 2.8e-25, 47.36% id in 171 aa, and to Bacillus subtilis RNA polymerase sigma factor SigW SW:SIGW_BACSU (Q45585) (187 aa) fasta scores: E(): 3.9e-10, 31.39% id in 172 aa; RNA polymerase sigma factor complement(81172..81756) Corynebacterium diphtheriae NCTC 13129 2648517 NP_938497.1 CDS DIP0100 NC_002935.2 81783 82181 R hypothetical protein complement(81783..82181) Corynebacterium diphtheriae NCTC 13129 2650499 NP_938498.1 CDS DIP0101 NC_002935.2 82259 83899 D Similar to Mycobacterium tuberculosis DipZ protein Rv2874 or MT2942 or MTCY274.05 SW:DIPZ_MYCTU (Q10801) (695 aa) fasta scores: E(): 1.6e-43, 43.65% id in 591 aa; hypothetical protein 82259..83899 Corynebacterium diphtheriae NCTC 13129 2650500 NP_938499.1 CDS tipA NC_002935.2 83969 84745 R Similar to Streptomyces coelicolor transcriptional activator TipA or SCE9.20 SW:TIPA_STRCO (P32184) (253 aa) fasta scores: E(): 5.3e-24, 35.85% id in 251 aa; transcriptional activator complement(83969..84745) Corynebacterium diphtheriae NCTC 13129 2650501 NP_938500.1 CDS DIP0103 NC_002935.2 84797 84964 R Similar to Mycobacterium leprae hypothetical protein ML2114 TR:Q9CBE3 (EMBL:AL583924) (56 aa) fasta scores: E(): 1.7e-05, 52.08% id in 48 aa; hypothetical protein complement(84797..84964) Corynebacterium diphtheriae NCTC 13129 2649070 NP_938501.1 CDS DIP0104 NC_002935.2 84975 86321 R Similar to Streptomyces coelicolor peptidase SCI52.18c TR:Q9AD91 (EMBL:AL590507) (445 aa) fasta scores: E(): 1e-31, 32.04% id in 440 aa; peptidase complement(84975..86321) Corynebacterium diphtheriae NCTC 13129 2649071 NP_938502.1 CDS bioB NC_002935.2 86342 87394 D catalyzes the formation of biotin from dethiobiotin and sulfur 2 S-adenosyl-L-methionine; biotin synthase 86342..87394 Corynebacterium diphtheriae NCTC 13129 2649072 NP_938503.1 CDS DIP0106 NC_002935.2 87394 87654 D Similar to Mycobacterium tuberculosis hypothetical 8.6 kDa protein Rv1590 or MT1625 or MTCY336.14c TR:O06600 (EMBL:Z95586) (79 aa) fasta scores: E(): 4.1e-11, 67.24% id in 58 aa; hypothetical protein 87394..87654 Corynebacterium diphtheriae NCTC 13129 2649073 NP_938504.1 CDS irp6A NC_002935.2 88041 89228 D Almost identical to previously sequenced Corynebacterium diphtheriae ferrisiderophore receptor Irp6A SWALL:Q8VVA8 (EMBL:AY061890) (395 aa) fasta scores: E(): 8.7e-146, 97.46% id in 395 aa; ferrisiderophore receptor Irp6A 88041..89228 Corynebacterium diphtheriae NCTC 13129 2649038 NP_938505.1 CDS irp6B NC_002935.2 89229 90272 D Almost identical to previously sequenced Corynebacterium diphtheriae membrane protein permease Irp6B SWALL:Q8VVA7 (EMBL:AY061890) (347 aa) fasta scores: E(): 1e-116, 98.27% id in 347 aa and similar to Rhizobium meliloti iron ABC transporter permease SMB21430 TR:CAC49658 (EMBL:AL603646) (356 aa) fasta scores: E(): 1.6e-55, 50.87% id in 342 aa and to Corynebacterium diphtheriae HmuU SWALL:Q9XD88 (EMBL:AF109162) (350 aa) fasta scores: E(): 2.1e-36, 40.66% id in 332 aa; membrane protein permease Irp6B 89229..90272 Corynebacterium diphtheriae NCTC 13129 2649039 NP_938506.1 CDS irp6C NC_002935.2 90274 91032 D Almost identical to previously sequenced Corynebacterium diphtheriae ATP-binding protein Irp6C SWALL:Q8VVA6 (EMBL:AY061890) (252 aa) fasta scores: E(): 1.4e-79, 99.6% id in 252 aa and similar to Escherichia coli iron FecE or B4287 SWALL:FECE_ECOLI (SWALL:P15031) (255 aa) fasta scores: E(): 5.7e-19, 37.64% id in 263 aa; ATP-binding protein Irp6C 90274..91032 Corynebacterium diphtheriae NCTC 13129 2649040 NP_938507.1 CDS DIP0111 NC_002935.2 91122 92600 D Similar to Corynebacterium glutamicum ATCC 13032 hypothetical protein CGL1283 SWALL:BAB98676 (EMBL:AP005278) (581 aa) fasta scores: E(): 1.8e-63, 45.63% id in 504 aa; lipoprotein 91122..92600 Corynebacterium diphtheriae NCTC 13129 2650429 NP_938508.1 CDS DIP0112 NC_002935.2 92618 93025 D Similar to Bacillus subtilis YdhG protein TR:O05499 (EMBL:D88802) (135 aa) fasta scores: E(): 2.3e-20, 41.46% id in 123 aa; hypothetical protein 92618..93025 Corynebacterium diphtheriae NCTC 13129 2650430 NP_938509.1 CDS DIP0113 NC_002935.2 93040 94380 D Similar to Streptomyces griseus deoxyribodipyrimidine photolyase Phr SW:PHR_STRGR (P12768) (455 aa) fasta scores: E(): 3.5e-36, 36.75% id in 468 aa, and to Escherichia coli deoxyribodipyrimidine photolyase PhrB or Phr or B0708 SW:PHR_ECOLI (P00914) (472 aa) fasta scores: E(): 9.9e-32, 34.01% id in 488 aa; riboflavin biosynthesis protein 93040..94380 Corynebacterium diphtheriae NCTC 13129 2650431 NP_938510.1 CDS DIP0114 NC_002935.2 94403 94822 D Similar to Staphylococcus aureus subsp aureus N315 hypothetical protein SA2163 TR:Q99RQ4 (EMBL:AP003137) (143 aa) fasta scores: E(): 2.4e-15, 39.16% id in 143 aa; hypothetical protein 94403..94822 Corynebacterium diphtheriae NCTC 13129 2650624 NP_938511.1 CDS DIP0115 NC_002935.2 94809 95876 R Similar to Streptomyces coelicolor hypothetical 39.2 kDa protein SCH24.21c TR:Q9X8T5 (EMBL:AL049826) (360 aa) fasta scores: E(): 5e-111, 79.49% id in 356 aa; hypothetical protein complement(94809..95876) Corynebacterium diphtheriae NCTC 13129 2648477 NP_938512.1 CDS DIP0116 NC_002935.2 96123 96881 R Similar to Rhizobium loti MLR6622 protein TR:Q988S0 (EMBL:AP003009) (231 aa) fasta scores: E(): 1.4e-25, 40.99% id in 222 aa; hypothetical protein complement(96123..96881) Corynebacterium diphtheriae NCTC 13129 2650180 NP_938513.1 CDS DIP0117 NC_002935.2 96976 97758 R Similar to Streptomyces coelicolor secreted lipase SCI11.24c TR:Q9S295 (EMBL:AL096849) (290 aa) fasta scores: E(): 6.8e-20, 33.18% id in 223 aa, and to Pseudomonas sp lipase precursor Lip SW:LIP_PSES5 (P25275) (364 aa) fasta scores: E(): 5.6e-05, 28.4% id in 176 aa; lipase complement(96976..97758) Corynebacterium diphtheriae NCTC 13129 2650181 NP_938514.1 CDS DIP0118 NC_002935.2 97855 98433 D Similar to Thermus aquaticus NADH dehydrogenase Nox SW:NOX_THETH (Q60049) (205 aa) fasta scores: E(): 3.2e-07, 34.18% id in 196 aa; dehydrogenase 97855..98433 Corynebacterium diphtheriae NCTC 13129 2650182 NP_938515.1 CDS DIP0119 NC_002935.2 98438 100177 R Similar to Deinococcus radiodurans ATP-dependent DNA helicase RecG-related protein DR2199 TR:Q9RSC6 (EMBL:AE002053) (596 aa) fasta scores: E(): 8.9e-13, 24.04% id in 445 aa; hypothetical protein complement(98438..100177) Corynebacterium diphtheriae NCTC 13129 2650183 NP_938516.1 CDS DIP0121 NC_002935.2 <100588 100722 D Similar to parts of Mycobacterium smegmatis TnpA protein TR:Q50440 (EMBL:M76495) (413 aa) fasta scores: E(): 0.8, 44.44% id in 36 aa; transposon (partial) <100588..100722 Corynebacterium diphtheriae NCTC 13129 2650571 NP_938517.1 CDS DIP0122 NC_002935.2 101238 101792 D Similar to Streptomyces coelicolor siderophore binding protein SCBAC36F5.26 TR:CAC42862 (EMBL:AL592292) (178 aa) fasta scores: E(): 6.3e-25, 48.48% id in 165 aa; siderophore binding protein 101238..101792 Corynebacterium diphtheriae NCTC 13129 2650572 NP_938518.1 CDS DIP0123 NC_002935.2 101789 102787 R Similar to Mycobacterium tuberculosis hypothetical 46.1 kDa protein Rv0485 or MT0503 or MTCY20G9.11 SW:Y485_MYCTU (Q11151) (438 aa) fasta scores: E(): 1.4e-12, 32.14% id in 224 aa; hypothetical protein complement(101789..102787) Corynebacterium diphtheriae NCTC 13129 2650573 NP_938519.1 CDS DIP0124 NC_002935.2 103155 104525 D Similar to Streptomyces coelicolor integral membrane protein SCBAC19F3.14 TR:CAC44337 (EMBL:AL596102) (517 aa) fasta scores: E(): 3.6e-47, 37.96% id in 453 aa; hypothetical protein 103155..104525 Corynebacterium diphtheriae NCTC 13129 2650515 NP_938520.1 CDS DIP0125 NC_002935.2 104676 105761 D Similar to the C-terminal region of Pseudomonas aeruginosa hypothetical protein PA4923 SW:YDC3_PSEAE (P48636) (195 aa) fasta scores: E(): 3.3e-27, 44.97% id in 189 aa; hypothetical protein 104676..105761 Corynebacterium diphtheriae NCTC 13129 2650516 NP_938521.1 CDS DIP0126 NC_002935.2 105773 107386 D Similar to Streptomyces coelicolor conserved hypothetical protein SCBAC36F5.07 TR:CAC42843 (EMBL:AL592292) (562 aa) fasta scores: E(): 3.6e-40, 35.62% id in 553 aa; hypothetical protein 105773..107386 Corynebacterium diphtheriae NCTC 13129 2650517 NP_938522.1 CDS DIP0127 NC_002935.2 107390 107860 D Similar to Streptomyces coelicolor regulatory protein SCE50.15 TR:Q9L048 (EMBL:AL163672) (168 aa) fasta scores: E(): 3.3e-18, 41.89% id in 148 aa; MarR family transcriptional regulator 107390..107860 Corynebacterium diphtheriae NCTC 13129 2650518 NP_938523.1 CDS DIP0128 NC_002935.2 107838 108890 R Similar to Escherichia coli AbrB protein or B0715 SW:ABRB_ECOLI (P75747) (348 aa) fasta scores: E(): 3.6e-20, 30.72% id in 345 aa; hypothetical protein complement(107838..108890) Corynebacterium diphtheriae NCTC 13129 2650519 NP_938524.1 CDS DIP0129 NC_002935.2 108895 109479 R hypothetical protein complement(108895..109479) Corynebacterium diphtheriae NCTC 13129 2650509 NP_938525.1 CDS DIP0130 NC_002935.2 109478 110248 D Similar to Streptomyces coelicolor hypothetical 26.0 kDa protein SC7A8.24c TR:Q9L2D4 (EMBL:AL137187) (260 aa) fasta scores: E(): 1e-34, 42.8% id in 257 aa; hypothetical protein 109478..110248 Corynebacterium diphtheriae NCTC 13129 2650510 NP_938526.1 CDS DIP0131 NC_002935.2 110238 112583 R Similar to Escherichia coli ATP-dependent helicase HrpB or B0148 SW:HRPB_ECOLI (P37024) (809 aa) fasta scores: E(): 2.6e-40, 35.09% id in 815 aa; ATP-dependent helicase complement(110238..112583) Corynebacterium diphtheriae NCTC 13129 2650511 NP_938527.1 CDS DIP0132 NC_002935.2 112573 113142 R Similar to Streptomyces coelicolor sugar acetyltransferase SCBAC25F8.11c TR:CAC42146 (EMBL:AL592126) (193 aa) fasta scores: E(): 2.2e-24, 44.7% id in 170 aa, and to Escherichia coli galactoside O-acetyltransferase LacA or B0342 SWALL:THGA_ECOLI (SWALL:P07464) (203 aa) fasta scores: E(): 2.3e-21, 36.51% id in 178 aa; sugar acetyltransferase complement(112573..113142) Corynebacterium diphtheriae NCTC 13129 2649985 NP_938528.1 CDS DIP0133 NC_002935.2 113144 113884 D Similar to Escherichia coli alkylated DNA repair protein Alkb or AidD or B2212 SW:ALKB_ECOLI (P05050) (216 aa) fasta scores: E(): 1.4e-12, 35.02% id in 237 aa; DNA repair protein 113144..113884 Corynebacterium diphtheriae NCTC 13129 2649986 NP_938529.1 CDS DIP0134 NC_002935.2 113937 114524 D Similar to Mycobacterium tuberculosis CDC1551 DNA-3-methyladenine glycosidase I MT1248 TR:AAK45505 (EMBL:AE007001) (204 aa) fasta scores: E(): 8.3e-35, 52.71% id in 184 aa, and to Escherichia coli DNA-3-methyladenine glycosylase I Tag or B3549 SW:3MG1_ECOLI (P05100) (187 aa) fasta scores: E(): 1.5e-25, 44.88% id in 176 aa; DNA-repair protein 113937..114524 Corynebacterium diphtheriae NCTC 13129 2649987 NP_938530.1 CDS DIP0135 NC_002935.2 114529 115257 D Similar to Mycobacterium tuberculosis oxidoreductase Rv0484c or MT0502 or MTCY20G9.10c SW:Y484_MYCTU (Q11150) (251 aa) fasta scores: E(): 1.2e-45, 57.32% id in 232 aa; oxidoreductase 114529..115257 Corynebacterium diphtheriae NCTC 13129 2649988 NP_938531.1 CDS DIP0136 NC_002935.2 115518 116276 D lipoprotein 115518..116276 Corynebacterium diphtheriae NCTC 13129 2648518 NP_938532.1 CDS DIP0137 NC_002935.2 116460 116687 R Similar to a region of Corynebacterium glutamicum Ycg4K TR:Q9EUM3 (EMBL:AF164956) (256 aa) fasta scores: E(): 9.2e-09, 75.61% id in 41 aa; hypothetical protein complement(116460..116687) Corynebacterium diphtheriae NCTC 13129 2648519 NP_938533.1 CDS DIP0138 NC_002935.2 116920 117045 R Doubtful CDS. No significant database matches; hypothetical protein complement(116920..117045) Corynebacterium diphtheriae NCTC 13129 2648520 NP_938534.1 CDS DIP0139 NC_002935.2 117050 117379 R hypothetical protein complement(117050..117379) Corynebacterium diphtheriae NCTC 13129 2648521 NP_938535.1 CDS DIP0140 NC_002935.2 117622 >117900 R Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein complement(117622..>117900) Corynebacterium diphtheriae NCTC 13129 2648759 NP_938536.1 CDS DIP0141 NC_002935.2 118089 118232 D Doubtful CDS. No significant database matches; hypothetical protein 118089..118232 Corynebacterium diphtheriae NCTC 13129 2648760 NP_938537.1 CDS DIP0142 NC_002935.2 118306 118980 D hypothetical protein 118306..118980 Corynebacterium diphtheriae NCTC 13129 2648761 NP_938538.1 CDS DIP0145 NC_002935.2 120068 120265 R Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein complement(120068..120265) Corynebacterium diphtheriae NCTC 13129 2648763 NP_938539.1 CDS DIP0146 NC_002935.2 120487 120867 D integral membrane protein 120487..120867 Corynebacterium diphtheriae NCTC 13129 2648764 NP_938540.1 CDS DIP0147 NC_002935.2 120867 120974 D Doubtful CDS. No significant database matches; lipoprotein 120867..120974 Corynebacterium diphtheriae NCTC 13129 2648508 NP_938541.1 CDS DIP0149 NC_002935.2 121423 121722 D Similar to Bacillus subtilis hypothetical 7.9 kDa protein in dnaN-recF intergenic region YaaA SW:YAAA_BACSU (P05650) (71 aa) fasta scores: E(): 2.5e-05, 44.92% id in 69 aa; hypothetical protein 121423..121722 Corynebacterium diphtheriae NCTC 13129 2648510 NP_938542.1 CDS DIP0150 NC_002935.2 121722 122546 D Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT0934.1 TR:AAK45182 (EMBL:AE006980) (257 aa) fasta scores: E(): 3.3e-32, 41.96% id in 255 aa; hypothetical protein 121722..122546 Corynebacterium diphtheriae NCTC 13129 2648511 NP_938543.1 CDS DIP0151 NC_002935.2 122552 122857 D Similar to Streptomyces coelicolor conserved hypothetical protein SC10F4.36c TR:Q9F3M5 (EMBL:AL450350) (94 aa) fasta scores: E(): 8.6e-07, 38.2% id in 89 aa, and to Mycobacterium tuberculosis hypothetical 11.0 kDa protein Rv3204 or MTCY07D11.22c TR:O05862 (EMBL:Z95120) (101 aa) fasta scores: E(): 0.00013, 40% id in 95 aa; hypothetical protein 122552..122857 Corynebacterium diphtheriae NCTC 13129 2648512 NP_938544.1 CDS DIP0152 NC_002935.2 122867 123787 R hypothetical protein complement(122867..123787) Corynebacterium diphtheriae NCTC 13129 2648513 NP_938545.1 CDS DIP0153 NC_002935.2 123927 124553 D hypothetical protein 123927..124553 Corynebacterium diphtheriae NCTC 13129 2648514 NP_938546.1 CDS DIP0154 NC_002935.2 124561 126570 R Similar to Mycobacterium tuberculosis CDC1551 endopeptidase, peptidase M13 MT0208 TR:AAK44429 (EMBL:AE006930) (663 aa) fasta scores: E(): 2.9e-89, 46.97% id in 662 aa; endopeptidase complement(124561..126570) Corynebacterium diphtheriae NCTC 13129 2650574 NP_938547.1 CDS DIP0155 NC_002935.2 126599 127231 D No significant database matches. Possible secreted protein; hypothetical protein 126599..127231 Corynebacterium diphtheriae NCTC 13129 2650575 NP_938548.1 CDS DIP0156 NC_002935.2 127228 128148 D No significant database matches. Possible membrane protein; hypothetical protein 127228..128148 Corynebacterium diphtheriae NCTC 13129 2650576 NP_938549.1 CDS DIP0157 NC_002935.2 128138 129046 D Similar to Mycobacterium tuberculosis CDC1551 amino acid ABC transporter, amino acid-binding protein, MT3866 TR:AAK48230 (EMBL:AE007181) (343 aa) fasta scores: E(): 2.6e-26, 35.69% id in 311 aa; hypothetical protein 128138..129046 Corynebacterium diphtheriae NCTC 13129 2650577 NP_938550.1 CDS DIP0158 NC_002935.2 129067 129504 R No significant database matches. Possible secreted protein; hypothetical protein complement(129067..129504) Corynebacterium diphtheriae NCTC 13129 2650578 NP_938551.1 CDS DIP0159 NC_002935.2 129730 133155 R Similar to Mycobacterium tuberculosis CDC1551 arabinosyl transferase MT3902 TR:AAK48268 (EMBL:AE007183) (1098 aa) fasta scores: E(): 1.3e-49, 38.11% id in 1149 aa; transferase complement(129730..133155) Corynebacterium diphtheriae NCTC 13129 2650512 NP_938552.1 CDS DIP0160 NC_002935.2 133148 135232 R Similar to Mycobacterium tuberculosis hypothetical 69.5 kDa protein CY13D12.26 Rv3792 or MTCY13D12.26 TR:P72058 (EMBL:Z80343) (643 aa) fasta scores: E(): 3.7e-53, 34.5% id in 652 aa; hypothetical protein complement(133148..135232) Corynebacterium diphtheriae NCTC 13129 2650513 NP_938553.1 CDS DIP0161 NC_002935.2 135343 136104 R Similar to Mycobacterium leprae oxidoreductase ML0108 TR:Q9CDA5 (EMBL:AL583917) (254 aa) fasta scores: E(): 5.6e-50, 57.14% id in 252 aa; short chain dehydrogenase complement(135343..136104) Corynebacterium diphtheriae NCTC 13129 2650514 NP_938554.1 CDS DIP0162 NC_002935.2 136124 137590 R Similar to Mycobacterium tuberculosis CDC1551 oxidoreductase, FAD-binding MT3898 TR:AAK48263 (EMBL:AE007183) (463 aa) fasta scores: E(): 4.2e-118, 67.57% id in 478 aa; oxidoreductase, FAD-binding complement(136124..137590) Corynebacterium diphtheriae NCTC 13129 2648828 NP_938555.1 CDS DIP0163 NC_002935.2 137707 137955 R hypothetical protein complement(137707..137955) Corynebacterium diphtheriae NCTC 13129 2648829 NP_938556.1 CDS DIP0164 NC_002935.2 137984 138418 D No significant database matches. Possible membrane protein; hypothetical protein 137984..138418 Corynebacterium diphtheriae NCTC 13129 2648830 NP_938557.1 CDS DIP0165 NC_002935.2 138415 138963 D hypothetical protein 138415..138963 Corynebacterium diphtheriae NCTC 13129 2648831 NP_938558.1 CDS DIP0166 NC_002935.2 138975 139394 D Similar to Mycobacterium tuberculosis hypothetical 13.4 kDa protein Rv3789 or MT3897 or MTCY13D12.23 SW:Y1I9_MYCTU (P72055) (121 aa) fasta scores: E(): 4.2e-17, 48.78% id in 123 aa; hypothetical protein 138975..139394 Corynebacterium diphtheriae NCTC 13129 2648573 NP_938559.1 CDS DIP0167 NC_002935.2 139604 140383 D No significant database matches. Note: Also similar to DIP2059 (271 aa) E(): 1e-38; 44.747% identity in 257 aa overlap; hypothetical protein 139604..140383 Corynebacterium diphtheriae NCTC 13129 2648574 NP_938560.1 CDS DIP0168 NC_002935.2 140517 141434 R Similar to Mycobacterium tuberculosis CDC1551 glycosyl transferase MT3891 TR:AAK48256 (EMBL:AE007182) (304 aa) fasta scores: E(): 1.8e-71, 62.17% id in 304 aa; glycosyl transferase family protein complement(140517..141434) Corynebacterium diphtheriae NCTC 13129 2648575 NP_938561.1 CDS DIP0169 NC_002935.2 141608 142573 D Similar to Treponema pallidum periplasmic zinc-binding protein TroA or TroMP1 or TP0163 SWALL:TROA_TREPA (SWALL:P96116) (308 aa) fasta scores: E(): 4.2e-29, 35.27% id in 292 aa, and to Streptococcus pneumoniae manganese ABC transporter substrate-binding lipoprotein precursor PsaA or SP1650 SWALL:P72538 (EMBL:U53509) (309 aa) fasta scores: E(): 1.6e-19, 28.47% id in 309 aa, and to Streptococcus gordonii challis coagregation-mediating adhesin precursor ScaA SW:ADHS_STRGC () (310 aa) fasta scores: E(): 1.9e-20, 30.15% id in 315 aa. Note: Also similar to the downstream DIP0173 (333 aa) E(): 6.5e-38;56.061% identity in 330 aa overlap. Contains a twin-arginine translocation (TAT) system recognition motif (RRGFIR) at the N-terminal region; hypothetical protein 141608..142573 Corynebacterium diphtheriae NCTC 13129 2648576 NP_938562.1 CDS DIP0170 NC_002935.2 142673 143407 D Similar to Bacillus subtilis probable metal transport system ATP-binding protein YtgB SW:YTGB_BACSU (O34338) (250 aa) fasta scores: E(): 5.3e-33, 45.61% id in 228 aa, and to Streptococcus gordonii challis hypothetical ABC transporter ATP-binding protein in ScaA 5'region SW:YSC1_STRGC (P42360) (251 aa) fasta scores: E(): 4.6e-30, 40.26% id in 231 aa; hypothetical protein 142673..143407 Corynebacterium diphtheriae NCTC 13129 2650622 NP_938563.1 CDS DIP0171 NC_002935.2 143404 144303 D Similar to Bacillus subtilis probable metal transport system membrane protein YtgC SW:YTGC_BACSU (O35024) (435 aa) fasta scores: E(): 3.1e-22, 33.91% id in 286 aa, and to Treponema pallidum zinc transport system membrane protein TroC or TP0165 SW:TROC_TREPA (P96118) (298 aa) fasta scores: E(): 1.5e-21, 35.69% id in 297 aa; hypothetical protein 143404..144303 Corynebacterium diphtheriae NCTC 13129 2650623 NP_938564.1 CDS DIP0172 NC_002935.2 144300 145151 D Similar to Treponema pallidum zinc transport system membrane protein Trod or TP0166 SW:TROD_TREPA (P96119) (367 aa) fasta scores: E(): 3.4e-27, 35.97% id in 278 aa, and to Bacillus subtilis YtgD TR:O34500 (EMBL:AF008220) (295 aa) fasta scores: E(): 2.8e-25, 35.92% id in 270 aa; hypothetical protein 144300..145151 Corynebacterium diphtheriae NCTC 13129 2650437 NP_938565.1 CDS DIP0173 NC_002935.2 145272 146273 D Similar to Neisseria meningitidis periplasmic binding protein NMA0789 SWALL:Q9JVL4 (EMBL:AL162754) (308 aa) fasta scores: E(): 2.7e-24, 31.71% id in 309 aa, and to Treponema pallidum periplasmic zinc-binding protein TroA or TroMP1 or TP0163 SWALL:TROA_TREPA (SWALL:P96116) (308 aa) fasta scores: E(): 2.5e-16, 33.12% id in 317 aa, and to Streptococcus pyogenes zinc-binding protein precursor AdcA or SPY0714 SWALL:Q9A0L9 (EMBL:AE006523) (515 aa) fasta scores: E(): 2.5e-16, 28.85% id in 298 aa Note: Also similar to the upstream DIP0169, (321 aa) E(): 4.5e-38; 56.798% identity in 331 aa overlap; hypothetical protein 145272..146273 Corynebacterium diphtheriae NCTC 13129 2650438 NP_938566.1 CDS DIP0174 NC_002935.2 146339 147118 R Similar to Mycobacterium leprae ABC transporter ATP-binding component ML0114 SWALL:Q9CDA0 (EMBL:AL583917) (272 aa) fasta scores: E(): 2.3e-60, 74.4% id in 254 aa, and to Xylella fastidiosa ABC transporter ATP-binding protein XF2568 SWALL:Q9PAF0 (EMBL:AE004064) (246 aa) fasta scores: E(): 1.4e-34, 45.93% id in 246 aa; ABC transporter ATP-binding protein complement(146339..147118) Corynebacterium diphtheriae NCTC 13129 2649041 NP_938567.1 CDS DIP0175 NC_002935.2 147137 147997 R Similar to Mycobacterium leprae ABC transporter component ML0112 SWALL:Q9CDA2 (EMBL:AL583917) (276 aa) fasta scores: E(): 1.2e-60, 55.23% id in 277 aa, and to Xylella fastidiosa ABC transporter permease XF2567 SWALL:Q9PAF1 (EMBL:AE004064) (267 aa) fasta scores: E(): 5.2e-37, 36.5% id in 263 aa; ABC transporter permease complement(147137..147997) Corynebacterium diphtheriae NCTC 13129 2649042 NP_938568.1 CDS DIP0176 NC_002935.2 148133 149326 D Similar to Mycobacterium leprae hypothetical protein ML0117 TR:Q9CD97 (EMBL:AL583917) (398 aa) fasta scores: E(): 8.1e-38, 35.73% id in 417 aa; hypothetical protein 148133..149326 Corynebacterium diphtheriae NCTC 13129 2649043 NP_938569.1 CDS DIP0177 NC_002935.2 149323 150270 R Similar to Streptomyces coelicolor quinone oxidoreductase SCGD3.24c TR:Q9XA55 (EMBL:AL096822) (326 aa) fasta scores: E(): 1.4e-57, 53.87% id in 323 aa; quinone oxidoreductase complement(149323..150270) Corynebacterium diphtheriae NCTC 13129 2649044 NP_938570.1 CDS DIP0178 NC_002935.2 150627 151661 R Similar to Streptomyces coelicolor histidinol-phophate aminotransferase SCD78.11 TR:Q9ZBY8 (EMBL:AL034355) (359 aa) fasta scores: E(): 6.9e-55, 49.85% id in 345 aa, and to Streptomyces tendae NikT protein TR:Q9F2E4 (EMBL:AJ250581) (440 aa) fasta scores: E(): 1.1e-42, 42.9% id in 324 aa; aminotransferase complement(150627..151661) Corynebacterium diphtheriae NCTC 13129 2648854 NP_938571.1 CDS DIP0179 NC_002935.2 152426 154000 D Similar to Staphylococcus aureus subsp aureus Mu50 hypothetical 57.2 kDa protein SAV1916 TR:BAB58078 (EMBL:AP003363) (520 aa) fasta scores: E(): 3.6e-71, 41.38% id in 505 aa, and to Helicobacter pylori sodium-dependent transporter HP0214 TR:O25003 (EMBL:AE000541) (552 aa) fasta scores: E(): 9.3e-34, 50.45% id in 555 aa; hypothetical protein 152426..154000 Corynebacterium diphtheriae NCTC 13129 2648857 NP_938572.1 CDS DIP0180 NC_002935.2 154365 154994 D hypothetical protein 154365..154994 Corynebacterium diphtheriae NCTC 13129 2650555 NP_938573.1 CDS DIP0181 NC_002935.2 155099 155371 D hypothetical protein 155099..155371 Corynebacterium diphtheriae NCTC 13129 2650556 NP_938574.1 CDS DIP0182 NC_002935.2 155600 156826 R Similar to Mycobacterium phage MS6 Integrase Int TR:O55248 (EMBL:AF030986) (372 aa) fasta scores: E(): 1.5e-09, 26.48% id in 370 aa; phage integrase complement(155600..156826) Corynebacterium diphtheriae NCTC 13129 2650557 NP_938575.1 CDS DIP0183 NC_002935.2 156926 157948 R Similar to Streptococcus pneumoniae transcriptional regulator SP1809 TR:AAK75882 (EMBL:AE007473) (383 aa) fasta scores: E(): 8.2e-14, 29.35% id in 310 aa; transcriptional regulator complement(156926..157948) Corynebacterium diphtheriae NCTC 13129 2650558 NP_938576.1 CDS DIP0184 NC_002935.2 157960 158523 R hypothetical protein complement(157960..158523) Corynebacterium diphtheriae NCTC 13129 2650559 NP_938577.1 CDS DIP0185 NC_002935.2 158618 159025 R hypothetical protein complement(158618..159025) Corynebacterium diphtheriae NCTC 13129 2650678 NP_938578.1 CDS DIP0186 NC_002935.2 159035 159196 R hypothetical protein complement(159035..159196) Corynebacterium diphtheriae NCTC 13129 2650679 NP_938579.1 CDS DIP0187 NC_002935.2 159639 159881 D Similar to Pyrococcus abyssi repressor protein, PAB7155 TR:Q9V101 (EMBL:AJ248284) (73 aa) fasta scores: E(): 0.002, 36.06% id in 61 aa; transcriptional regulator 159639..159881 Corynebacterium diphtheriae NCTC 13129 2650680 NP_938580.1 CDS DIP0188 NC_002935.2 160120 160446 R hypothetical protein complement(160120..160446) Corynebacterium diphtheriae NCTC 13129 2650681 NP_938581.1 CDS DIP0189 NC_002935.2 160470 160961 D hypothetical protein 160470..160961 Corynebacterium diphtheriae NCTC 13129 2650682 NP_938582.1 CDS DIP0190 NC_002935.2 160942 161760 D Similar to Staphylococcus aureus prophage phiPV83 antirepressor TR:Q9MBT0 (EMBL:AB044554) (265 aa) fasta scores: E(): 1.5e-32, 42.8% id in 257 aa; anti-repressor protein 160942..161760 Corynebacterium diphtheriae NCTC 13129 2650683 NP_938583.1 CDS DIP0191 NC_002935.2 161977 162219 D hypothetical protein 161977..162219 Corynebacterium diphtheriae NCTC 13129 2650684 NP_938584.1 CDS DIP0192 NC_002935.2 162231 162455 D No significant database matches. Possible exported protein; hypothetical protein 162231..162455 Corynebacterium diphtheriae NCTC 13129 2650685 NP_938585.1 CDS DIP0193 NC_002935.2 162452 162598 D hypothetical protein 162452..162598 Corynebacterium diphtheriae NCTC 13129 2650686 NP_938586.1 CDS DIP0194 NC_002935.2 162606 162875 D hypothetical protein 162606..162875 Corynebacterium diphtheriae NCTC 13129 2650687 NP_938587.1 CDS DIP0195 NC_002935.2 162868 163017 D hypothetical protein 162868..163017 Corynebacterium diphtheriae NCTC 13129 2650688 NP_938588.1 CDS DIP0196 NC_002935.2 163014 163457 D hypothetical protein 163014..163457 Corynebacterium diphtheriae NCTC 13129 2650689 NP_938589.1 CDS DIP0197 NC_002935.2 163482 163715 D hypothetical protein 163482..163715 Corynebacterium diphtheriae NCTC 13129 2650472 NP_938590.1 CDS DIP0197A NC_002935.2 163814 164122 D hypothetical protein 163814..164122 Corynebacterium diphtheriae NCTC 13129 2650473 NP_938591.1 CDS DIP0198 NC_002935.2 164151 165359 D hypothetical protein 164151..165359 Corynebacterium diphtheriae NCTC 13129 2650474 NP_938592.1 CDS DIP0199 NC_002935.2 165352 165966 D hypothetical protein 165352..165966 Corynebacterium diphtheriae NCTC 13129 2650475 NP_938593.1 CDS DIP0200 NC_002935.2 166018 166335 D hypothetical protein 166018..166335 Corynebacterium diphtheriae NCTC 13129 2650476 NP_938594.1 CDS DIP0203 NC_002935.2 168436 169686 D C-terminal region similar to Bacteriophage BFK20 portal protein TR:Q9MBK2 (EMBL:AJ278322) (215 aa) fasta scores: E(): 1e-40, 56.45% id in 209 aa, and N-terminal region to Bacteriophage BFK20 hypothetical 24.1 kDa protein TR:Q9MBK3 (EMBL:AJ278322) (213 aa) fasta scores: E(): 3.8e-29, 41.79% id in 201 aa. Note: It seems these two bacterophage proteins have been fused into DIP0203; hypothetical protein 168436..169686 Corynebacterium diphtheriae NCTC 13129 2650478 NP_938595.1 CDS DIP0204 NC_002935.2 169683 170726 D C-terminal region similar to Bacteriophage BFK20 prohead protease TR:Q9MBK0 (EMBL:AJ278322) (204 aa) fasta scores: E(): 1.1e-35, 66.46% id in 164 aa, and N-terminal region to Bacteriophage BFK20 hypothetical 18.4 kDa protein TR:Q9MBK1 (EMBL:AJ278322) (176 aa) fasta scores: E(): 6.2e-14, 51.06% id in 94 aa. Note: It seems these two bacterophage proteins have been fused into DIP0204; phage prohead protease 169683..170726 Corynebacterium diphtheriae NCTC 13129 2650479 NP_938596.1 CDS DIP0205 NC_002935.2 170723 171973 D Similar to Bacteriophage BFK20 major capsid protein TR:Q9MBJ9 (EMBL:AJ278322) (428 aa) fasta scores: E(): 5e-66, 47.14% id in 420 aa; phage capsid protein 170723..171973 Corynebacterium diphtheriae NCTC 13129 2650480 NP_938597.1 CDS DIP0206 NC_002935.2 171973 172173 D hypothetical protein 171973..172173 Corynebacterium diphtheriae NCTC 13129 2650481 NP_938598.1 CDS DIP0207 NC_002935.2 172195 172677 D Similar to Bacteriophage BFK20 hypothetical 19.9 kDa protein TR:Q9MBJ8 (EMBL:AJ278322) (180 aa) fasta scores: E(): 3.6e-16, 38.46% id in 156 aa; hypothetical protein 172195..172677 Corynebacterium diphtheriae NCTC 13129 2649121 NP_938599.1 CDS DIP0208 NC_002935.2 172674 173036 D hypothetical protein 172674..173036 Corynebacterium diphtheriae NCTC 13129 2649366 NP_938600.1 CDS DIP0208A NC_002935.2 173002 173295 D Similar to Bacteriophage BFK20 hypothetical 10.2 kDa protein TR:Q9MBJ7 (EMBL:AJ278322) (94 aa) fasta scores: E(): 2.5e-07, 44.57% id in 83 aa; hypothetical protein 173002..173295 Corynebacterium diphtheriae NCTC 13129 2650444 NP_938601.1 CDS DIP0209 NC_002935.2 173285 173662 D Similar to Bacteriophage BFK20 hypothetical 13.7 kDa protein TR:Q9MBJ6 (EMBL:AJ278322) (126 aa) fasta scores: E(): 1.5e-11, 37.06% id in 116 aa; hypothetical protein 173285..173662 Corynebacterium diphtheriae NCTC 13129 2650445 NP_938602.1 CDS DIP0210 NC_002935.2 173691 174638 D N-terminal region similar to Bacteriophage BFK20 hypothetical 13.9 kDa protein TR:Q9MBJ5 (EMBL:AJ278322) (125 aa) fasta scores: E(): 1.3e-21, 50% id in 116 aa, and C-terminal region to Bacteriophage BFK20 hypothetical 14.9 kDa protein TR:Q9MBJ4 (EMBL:AJ278322) (145 aa) fasta scores: E(): 3e-10, 37.85% id in 140 aa. Note: It seems these two bacterophage proteins have been fused into DIP0210; hypothetical protein 173691..174638 Corynebacterium diphtheriae NCTC 13129 2650446 NP_938603.1 CDS DIP0211 NC_002935.2 174736 175113 D Similar to Bacteriophage BFK20 hypothetical 15.7 kDa protein TR:Q9MBJ3 (EMBL:AJ278322) (138 aa) fasta scores: E(): 3.2e-08, 37.09% id in 124 aa; hypothetical protein 174736..175113 Corynebacterium diphtheriae NCTC 13129 2650447 NP_938604.1 CDS DIP0211A NC_002935.2 175275 175484 D hypothetical protein 175275..175484 Corynebacterium diphtheriae NCTC 13129 2650448 NP_938605.1 CDS DIP0212 NC_002935.2 175497 181139 D C-terminal region identical to Corynephage beta immunity-specific protein Beta241 TR:Q37919 (EMBL:L04258) (241 aa) fasta scores: E(): 3.1e-64, 100% id in 241 aa, and whole length similar to Staphylococcus aureus subspaureus Mu50 phi pvl ORF15 and 16 homologue SAV1955 TR:BAB58117 (EMBL:AP003364) (1509 aa) fasta scores: E(): 2.9e-19, 23.76% id in 1073 aa; hypothetical protein 175497..181139 Corynebacterium diphtheriae NCTC 13129 2650449 NP_938606.1 CDS beta201 NC_002935.2 181149 181901 D Similar to the previously sequenced Corynephage beta immunity-specific protein Beta201 TR:Q37920 (EMBL:L04258) (201 aa) fasta scores: E(): 3.9e-64, 85.64% id in 202 aa. Note: there is a frameshift in the already sequenced data in from residue 167; hypothetical protein 181149..181901 Corynebacterium diphtheriae NCTC 13129 2650482 NP_938607.1 CDS beta286 NC_002935.2 181902 182762 D Almost identical to previously sequenced Corynephage beta immunity-specific protein Beta286 TR:Q37921 (EMBL:L04258) (286 aa) fasta scores: E(): 1.1e-115, 99.65% id in 286 aa; hypothetical protein 181902..182762 Corynebacterium diphtheriae NCTC 13129 2650483 NP_938608.1 CDS beta371 NC_002935.2 182762 183877 D Almost identical to previously sequenced Corynephage beta immunity-specific protein Beta371 beta371 TR:Q37922 (EMBL:L04258) (371 aa) fasta scores: E(): 9.9e-126, 89.75% id in 371 aa; hypothetical protein 182762..183877 Corynebacterium diphtheriae NCTC 13129 2650484 NP_938609.1 CDS DIP0216 NC_002935.2 183877 185304 D Low similarity to N-terminal region of Bacteriophage lambda side tail fiber protein Stf SW:STF_LAMBD (P03764) (774 aa) fasta scores: E(): 0.0021, 24.28% id in 383 aa; phage tail fiber protein 183877..185304 Corynebacterium diphtheriae NCTC 13129 2650485 NP_938610.1 CDS DIP0217 NC_002935.2 185304 185978 D hypothetical protein 185304..185978 Corynebacterium diphtheriae NCTC 13129 2650486 NP_938611.1 CDS DIP0218 NC_002935.2 186059 187498 D C-terminal region similar to C-terminal region of Mycobacteriophage TM4 GP29 TR:Q9ZX49 (EMBL:AF068845) (547 aa) fasta scores: E(): 3.7e-35, 49.14% id in 234 aa; hypothetical protein 186059..187498 Corynebacterium diphtheriae NCTC 13129 2650487 NP_938612.1 CDS DIP0219 NC_002935.2 187501 187824 D hypothetical protein 187501..187824 Corynebacterium diphtheriae NCTC 13129 2650488 NP_938613.1 CDS DIP0220 NC_002935.2 187830 188294 D hypothetical protein 187830..188294 Corynebacterium diphtheriae NCTC 13129 2650489 NP_938614.1 CDS DIP0221 NC_002935.2 188291 188629 D hypothetical protein 188291..188629 Corynebacterium diphtheriae NCTC 13129 2650490 NP_938615.1 CDS tox NC_002935.2 188979 190661 D Identical to previously sequenced Corynephage beta diphtheria toxin precursor SW:DTX_CORBE (P00588) (567 aa) fasta scores: E(): 6.2e-216, 100% id in 560 aa, and to Corynephage omega diphtheria toxin precursor SW:DTX_COROM (P00587) (560 aa) fasta scores: E(): 1.1e-215, 99.82% id in 560 aa. Note: The start codon for DIP0222 is 7 residues downstream of the one in Corynephage beta; diphtheria toxin 188979..190661 Corynebacterium diphtheriae NCTC 13129 2650491 NP_938616.1 CDS DIP0223 NC_002935.2 190816 190992 D hypothetical protein 190816..190992 Corynebacterium diphtheriae NCTC 13129 2649548 NP_938617.1 CDS DIP0224 NC_002935.2 191070 191210 D hypothetical protein 191070..191210 Corynebacterium diphtheriae NCTC 13129 2649549 NP_938618.1 CDS DIP0225 NC_002935.2 191220 192626 D N-terminal region similar to Mycobacterium tuberculosis CDC1551 polysaccharide deacetylase, MT1128 TR:AAK45386 (EMBL:AE006993) (291 aa) fasta scores: E(): 2.1e-22, 42.43% id in 205 aa; secreted polysaccharide deacetylase 191220..192626 Corynebacterium diphtheriae NCTC 13129 2649550 NP_938619.1 CDS DIP0226 NC_002935.2 192614 193987 R Similar to Streptomyces coelicolor GntR-family regulator SC5G8.04 TR:Q9KZB0 (EMBL:AL353872) (462 aa) fasta scores: E(): 8.4e-38, 36.46% id in 458 aa; GntR family transcriptional regulator complement(192614..193987) Corynebacterium diphtheriae NCTC 13129 2648909 NP_938620.1 CDS DIP0227 NC_002935.2 194078 194971 D with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS 194078..194971 Corynebacterium diphtheriae NCTC 13129 2648727 NP_938621.1 CDS DIP0228 NC_002935.2 194965 195522 D with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT 194965..195522 Corynebacterium diphtheriae NCTC 13129 2648728 NP_938622.1 CDS DIP0229 NC_002935.2 195519 195686 R hypothetical protein complement(195519..195686) Corynebacterium diphtheriae NCTC 13129 2650492 NP_938623.1 CDS DIP0232 NC_002935.2 197202 197330 R hypothetical protein complement(197202..197330) Corynebacterium diphtheriae NCTC 13129 2650494 NP_938624.1 CDS DIP0233 NC_002935.2 197338 198327 R Similar to Actinomyces naeslundii fimbrial associated protein TR:O05996 (EMBL:U85709) (280 aa) fasta scores: E(): 4.5e-16, 40.000% id in 215 aa, and to Staphylococcus aureus sortase SrtA TR:Q9S446 (EMBL:AF162687) (206 aa) fasta scores: E(): 1.2, 26.923% id in 156 aa. Note: Also similar to DIP0236 (312 aa) E(): 5.7e-25; 45.342% identity in 322 aa overlap, DIP2224, DIP2012 and DIP2225; fimbrial associated sortase-like protein complement(197338..198327) Corynebacterium diphtheriae NCTC 13129 2650495 NP_938625.1 CDS DIP0234 NC_002935.2 198371 198847 D hypothetical protein 198371..198847 Corynebacterium diphtheriae NCTC 13129 2650496 NP_938626.1 CDS DIP0235 NC_002935.2 198862 200334 D Similar to Actinomyces viscosus type-1 fimbrial major subunit precursor FimP TR:Q9X4D1 (EMBL:AF106034) (535 aa) fasta scores: E(): 6.9e-16, 31.5% id in 530 aa. Note: Contains a potential sortase anchor site (LTMPG) upstream of the C-terminal region transmembrane domain; fimbrial subunit 198862..200334 Corynebacterium diphtheriae NCTC 13129 2650497 NP_938627.1 CDS DIP0236 NC_002935.2 200435 201373 D Similar to Actinomyces naeslundii fimbrial associated protein TR:O68213 (EMBL:AF019629) (365 aa) fasta scores: E(): 1.2e-31, 42.802% id in 257 aa, and to Staphylococcus aureus sortase SrtA TR:Q9S446 (EMBL:AF162687) (206 aa) fasta scores: E(): 0.094, 27.559% id in 127 aa. Note: Also similar to DIP0233 (329 aa) E(): 5.2e-25; 45.031% identity in 322 aa overlap. Note: Also similar to DIP2012, DIP2224 and DIP2225; fimbrial associated sortase-like protein 200435..201373 Corynebacterium diphtheriae NCTC 13129 2650498 NP_938628.1 CDS DIP0237 NC_002935.2 201366 202157 D No significant database matches. Note: Contains a potential sortase anchor site (LALTG) upstream of the C-terminal region transmembrane domain; surface anchored protein 201366..202157 Corynebacterium diphtheriae NCTC 13129 2648871 NP_938629.1 CDS DIP0238 NC_002935.2 202163 205282 D weak similarity to Actimomyces fimbrial associated protein. Note: Contains a potential sortase anchor site (LPKTG) upstream of the C-terminal region transmembrane domain; surface-anchored fimbrial subunit 202163..205282 Corynebacterium diphtheriae NCTC 13129 2648872 NP_938630.1 CDS DIP0240 NC_002935.2 205903 206310 R hypothetical protein complement(205903..206310) Corynebacterium diphtheriae NCTC 13129 2648874 NP_938631.1 CDS DIP0241 NC_002935.2 206336 206485 R hypothetical protein complement(206336..206485) Corynebacterium diphtheriae NCTC 13129 2650628 NP_938632.1 CDS DIP0242 NC_002935.2 206740 207051 R Similar to Burkholderia cepacia insertion element IS401 hypothetical 12.4 kDa protein SW:YISX_BURCE (Q51647) (107 aa) fasta scores: E(): 1.6e-06, 36.78% id in 87 aa; IS element transposase complement(206740..207051) Corynebacterium diphtheriae NCTC 13129 2650629 NP_938633.1 CDS DIP0243 NC_002935.2 207298 207492 R hypothetical protein complement(207298..207492) Corynebacterium diphtheriae NCTC 13129 2650630 NP_938634.1 CDS DIP0244 NC_002935.2 207638 208117 R No significant database matches. Possible secreted protein; hypothetical protein complement(207638..208117) Corynebacterium diphtheriae NCTC 13129 2650631 NP_938635.1 CDS DIP0245 NC_002935.2 208253 209263 R catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate; prephenate dehydrogenase complement(208253..209263) Corynebacterium diphtheriae NCTC 13129 2650632 NP_938636.1 CDS DIP0246 NC_002935.2 209301 209753 D Similar to Mycobacterium tuberculosis hypothetical 17.9 kDa protein Rv3753c or MTV025.10c TR:O69720 (EMBL:AL022121) (166 aa) fasta scores: E(): 1e-20, 45.57% id in 147 aa; Conserved hypothetical protein; hypothetical protein 209301..209753 Corynebacterium diphtheriae NCTC 13129 2650633 NP_938637.1 CDS DIP0247 NC_002935.2 209792 210235 D Similar to Bifidobacterium longum cytosine deaminase TR:Q9F9W7 (EMBL:AF160969) (143 aa) fasta scores: E(): 1.2e-28, 53.47% id in 144 aa, and to Mycobacterium tuberculosis CDC1551 cytidine and deoxycytidylate deaminase MT3859 TR:AAK48223 (EMBL:AE007181) (152 aa) fasta scores: E(): 6.9e-28, 53.47% id in 144 aa; cytosine deaminase 209792..210235 Corynebacterium diphtheriae NCTC 13129 2650634 NP_938638.1 CDS DIP0248 NC_002935.2 210640 211152 D Similar to Arthrobacter spTM1 excisionase TR:Q9LCU5 (EMBL:AF042490) (174 aa) fasta scores: E(): 4.4e-21, 41.07% id in 168 aa; excisionase 210640..211152 Corynebacterium diphtheriae NCTC 13129 2650636 NP_938639.1 CDS DIP0249 NC_002935.2 211399 211599 D Doubtful CDS. No significant database matches; hypothetical protein 211399..211599 Corynebacterium diphtheriae NCTC 13129 2650637 NP_938640.1 CDS DIP0250 NC_002935.2 211613 213949 D Similar to Streptomyces coelicolor membrane transport protein sce87.17C TR:Q9RKC1 (EMBL:AL132674) (745 aa) fasta scores: E(): 2.9e-36, 42.48% id in 798 aa; hypothetical protein 211613..213949 Corynebacterium diphtheriae NCTC 13129 2650579 NP_938641.1 CDS DIP0251 NC_002935.2 214616 215908 D Similar to Archaeoglobus fulgidus queuine tRNA-ribosyltransferase Tgt or AF1485 SW:TGT_ARCFU (O28787) (403 aa) fasta scores: E(): 8.6e-40, 40.78% id in 407 aa, and to Escherichia coli queuine tRNA-ribosyltransferase Tgt or B0406 or Z0505 or ECS0457 SW:TGT_ECOLI (P19675) (375 aa) fasta scores: E(): 4.5e-13, 37.68% id in 406 aa; tRNA-ribosyltransferase 214616..215908 Corynebacterium diphtheriae NCTC 13129 2650580 NP_938642.1 CDS DIP0252 NC_002935.2 215918 216811 D this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu; glutamyl-Q tRNA(Asp) synthetase 215918..216811 Corynebacterium diphtheriae NCTC 13129 2650581 NP_938643.1 CDS gntP NC_002935.2 216891 218279 D Similar to Corynebacterium glutamicum gluconate permease GntP TR:Q9AL75 (EMBL:AJ296014) (463 aa) fasta scores: E(): 2.9e-113, 69.34% id in 460 aa, and to Bacillus subtilis gluconate permease GntP SW:GNTP_BACSU (P12012) (448 aa) fasta scores: E(): 4.8e-53, 38.58% id in 451 aa; gluconate permease 216891..218279 Corynebacterium diphtheriae NCTC 13129 2649494 NP_938644.1 CDS DIP0254 NC_002935.2 218276 218779 R Similar to Streptomyces coelicolor gluconokinase SCI52.21 TR:Q9AD88 (EMBL:AL590507) (175 aa) fasta scores: E(): 4.2e-33, 60.39% id in 154 aa, and to Escherichia coli thermosensitive gluconokinase IdnK or GntV or B4268 SW:IDNK_ECOLI (P39208) (187 aa) fasta scores: E(): 3e-20, 44.15% id in 154 aa; transferase complement(218276..218779) Corynebacterium diphtheriae NCTC 13129 2649495 NP_938645.1 CDS DIP0255 NC_002935.2 218871 219080 R Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein complement(218871..219080) Corynebacterium diphtheriae NCTC 13129 2649496 NP_938646.1 CDS DIP0256 NC_002935.2 219238 219384 D Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 219238..219384 Corynebacterium diphtheriae NCTC 13129 2649498 NP_938647.1 CDS DIP0257 NC_002935.2 219574 220833 D Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT3825 TR:AAK48194 (EMBL:AE007179) (435 aa) fasta scores: E(): 5.2e-94, 55.95% id in 420 aa; hypothetical protein 219574..220833 Corynebacterium diphtheriae NCTC 13129 2650432 NP_938648.1 CDS DIP0258 NC_002935.2 220837 221388 D hypothetical protein 220837..221388 Corynebacterium diphtheriae NCTC 13129 2650433 NP_938649.1 CDS dnaX NC_002935.2 221399 223522 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 221399..223522 Corynebacterium diphtheriae NCTC 13129 2650434 NP_938650.1 CDS DIP0260 NC_002935.2 223595 223915 D Similar to Mycobacterium tuberculosis protein Rv3716c or MT3819 or MTV025.064c SW:Y1B6_MYCTU (O69683) (133 aa) fasta scores: E(): 2.7e-14, 54.16% id in 96 aa; hypothetical protein 223595..223915 Corynebacterium diphtheriae NCTC 13129 2650435 NP_938651.1 CDS recR NC_002935.2 223919 224575 D involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 223919..224575 Corynebacterium diphtheriae NCTC 13129 2650436 NP_938652.1 CDS DIP0262 NC_002935.2 224581 225333 R Similar to Mycobacterium tuberculosis CDC1551 cobyric acid synthase MT3816 TR:AAK48185 (EMBL:AE007178) (231 aa) fasta scores: E(): 1.3e-31, 58.13% id in 246 aa, and to Streptomyces coelicolor hypothetical 26.2 kDa protein 2SCG58.13 TR:Q9FCA0 (EMBL:AL391017) (242 aa) fasta scores: E(): 6.6e-20, 42.85% id in 252 aa; hypothetical protein complement(224581..225333) Corynebacterium diphtheriae NCTC 13129 2649284 NP_938653.1 CDS DIP0263 NC_002935.2 225335 226597 R Similar to Mycobacterium tuberculosis hypothetical 43.4 kDa protein Rv3712 or MTV025.060 TR:O69679 (EMBL:AL022121) (413 aa) fasta scores: E(): 2.3e-86, 59.95% id in 412 aa, and to Streptomyces coelicolor ligase 2SCG58.12 TR:Q9FCA1 (EMBL:AL391017) (412 aa) fasta scores: E(): 4.3e-59, 43.03% id in 409 aa; hypothetical protein complement(225335..226597) Corynebacterium diphtheriae NCTC 13129 2649285 NP_938654.1 CDS DIP0264 NC_002935.2 226618 227739 R 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon complement(226618..227739) Corynebacterium diphtheriae NCTC 13129 2649286 NP_938655.1 CDS DIP0265 NC_002935.2 227743 228507 R Similar to Escherichia coli oxygen-insensitive NADPH nitroreductase NfsA or MdaA or Mda18 or B0851 SW:NFSA_ECOLI (P17117) (240 aa) fasta scores: E(): 2e-23, 36.32% id in 223 aa; nitroreductase complement(227743..228507) Corynebacterium diphtheriae NCTC 13129 2649287 NP_938656.2 CDS leuA NC_002935.2 228555 230267 R Similar to Corynebacterium glutamicum 2-isopropylmalate synthase LeuA SW:LEU1_CORGL (P42455) (616 aa) fasta scores: E(): 2.5e-205, 83.27% id in 604 aa; 2-isopropylmalate synthase complement(228555..230267) Corynebacterium diphtheriae NCTC 13129 2649288 NP_938657.1 CDS DIP0267 NC_002935.2 230521 231552 D Similar to Bacillus subtilis deoxyribonucleoside regulator DeoR SW:DEOR_BACSU (P39140) (313 aa) fasta scores: E(): 6.6e-43, 42.9% id in 303 aa; regulatory protein 230521..231552 Corynebacterium diphtheriae NCTC 13129 2649289 NP_938658.1 CDS DIP0268 NC_002935.2 231758 232858 D C-terminal region similar to C-terminal region of Mycobacterium tuberculosis hypothetical 58.9 kDa protein Rv2100 precursor or MT2160 or MTCY49.40 SW:YL00_MYCTU (Q10709) (550 aa) fasta scores: E(): 7.5e-09, 35.11% id in 131 aa; hypothetical protein 231758..232858 Corynebacterium diphtheriae NCTC 13129 2649290 NP_938659.1 CDS deoD NC_002935.2 234348 235064 D catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 234348..235064 Corynebacterium diphtheriae NCTC 13129 2650521 NP_938660.1 CDS DIP0272 NC_002935.2 235061 236425 D Similar to Staphylococcus aureus SA0132 protein TR:Q99X78 (EMBL:AP003129) (450 aa) fasta scores: E(): 3.5e-67, 46.1% id in 436 aa, and to Bacillus subtilis tetracycline resistance protein TetB or Tet SW:TCRB_BACSU (P23054) (458 aa) fasta scores: E(): 1.3e-23, 26.3% id in 403 aa; antibiotic resistance protein membrane protein 235061..236425 Corynebacterium diphtheriae NCTC 13129 2650522 NP_938661.1 CDS deoC NC_002935.2 236460 237116 D catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 236460..237116 Corynebacterium diphtheriae NCTC 13129 2648850 NP_938662.1 CDS DIP0274 NC_002935.2 237124 238776 D Similar to Streptomyces coelicolor phosphomannomutase SCK13.08c TR:Q9AD82 (EMBL:AL512667) (549 aa) fasta scores: E(): 7.9e-86, 46.75% id in 554 aa; mutase 237124..238776 Corynebacterium diphtheriae NCTC 13129 2648851 NP_938663.1 CDS DIP0275 NC_002935.2 238823 239860 D Similar to Streptomyces coelicolor integral membrane protein 2SCI34.05 TR:Q9EWX4 (EMBL:AL445403) (396 aa) fasta scores: E(): 1.3e-08, 28.77% id in 358 aa; hypothetical protein 238823..239860 Corynebacterium diphtheriae NCTC 13129 2648852 NP_938664.1 CDS DIP0276 NC_002935.2 239862 240698 R Similar to Corynebacterium glutamicum hypothetical 29.6 kDa protein in leuA-lysC intergenic region SW:YLEU_CORGL (P42459) (270 aa) fasta scores: E(): 4.6e-47, 58.18% id in 220 aa; hypothetical protein complement(239862..240698) Corynebacterium diphtheriae NCTC 13129 2648853 NP_938665.1 CDS lysC NC_002935.2 240889 242154 D catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation.; aspartate kinase 240889..242154 Corynebacterium diphtheriae NCTC 13129 2648483 NP_938666.1 CDS DIP0278 NC_002935.2 242501 245743 D Low similarity to Staphylococcus aureus Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein SdrE or SAV0563 TR:BAB56725 (EMBL:AP003359) (1141 aa) fasta scores: E(): 1.9e-05, 21.85% id in 668 aa. Note: Contains a potential sortase anchor site (LARTG) upstream of the C-terminal region transmembrane domain; surface-anchored membrane protein 242501..245743 Corynebacterium diphtheriae NCTC 13129 2648484 NP_938667.1 CDS asd NC_002935.2 246016 247047 D catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 246016..247047 Corynebacterium diphtheriae NCTC 13129 2648485 NP_938668.1 CDS sigC NC_002935.2 247054 247620 R Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor complement(247054..247620) Corynebacterium diphtheriae NCTC 13129 2649074 NP_938669.1 CDS cat NC_002935.2 247748 249286 D Similar to Onchocerca volvulus endobacterium catalase Cat SW:CATA_ONCVE (Q27710) (482 aa) fasta scores: E(): 8e-92, 52.24% id in 490 aa; catalase 247748..249286 Corynebacterium diphtheriae NCTC 13129 2649075 NP_938670.1 CDS DIP0282 NC_002935.2 249276 250334 R Similar to Vibrio cholerae iron (III) ABC transporter, ATP-binding protein VC0610 TR:Q9KUB3 (EMBL:AE004146) (343 aa) fasta scores: E(): 7e-18, 34.743% id in 331 aa, and to Archaeoglobus fulgidus branched-chain amino acid ABC transporter, ATP-binding protein AF0221 TR:O30018 (EMBL:AE001090) (224 aa) fasta scores: E(): 9.2e-17, 34.562% id in 217 aa; ABC transporter ATP-binding protein complement(249276..250334) Corynebacterium diphtheriae NCTC 13129 2649076 NP_938671.1 CDS DIP0283 NC_002935.2 250325 251878 R Similar to Treponema hyodysenteriae permease ShiD TR:O54371 (EMBL:U75349) (277 aa) fasta scores: E(): 0.0013, 21.739% id in 184 aa, and to Escherichia coli O157:H7 EDL933 transport system permease YabK TR:AAG54371 (EMBL:AE005183) (536 aa) fasta scores: E(): 0.019, 21.995% id in 441 aa; transport system permease (iron) complement(250325..251878) Corynebacterium diphtheriae NCTC 13129 2649544 NP_938672.1 CDS DIP0284 NC_002935.2 251875 252876 R Similar to Escherichia coli O157:H7 periplasmic-iron-binding protein ECS0415 TR:BAB33838 (EMBL:AP002551) (343 aa) fasta scores: E(): 5.5e-19, 27.139% id in 339 aa, and to Actinobacillus pleuropneumoniae AfuA protein TR:Q57512 (EMBL:U05042) (346 aa) fasta scores: E(): 4.2e-16, 26.280% id in 293 aa, and to Serratia marcescens iron(III)-binding periplasmic protein precursor SfuA SW:SFUA_SERMA (P21408) (338 aa) fasta scores: E(): 0.00026, 20.000% id in 290 aa; ABC transporter complement(251875..252876) Corynebacterium diphtheriae NCTC 13129 2649545 NP_938673.1 CDS DIP0285 NC_002935.2 252957 254327 R Similar to Bacillus subtilis glycerol-3-phosphate transporter GlpT SW:GLPT_BACSU (P37948) (444 aa) fasta scores: E(): 1.4e-74, 45.434% id in 438 aa, and to Escherichia coli glycerol-3-phosphate transporter GlpT or B2240 SW:GLPT_ECOLI (P08194) (452 aa) fasta scores: E(): 4.2e-74, 44.295% id in 447 aa; glycerol-3-phosphate transporter complement(252957..254327) Corynebacterium diphtheriae NCTC 13129 2649546 NP_938674.1 CDS DIP0286 NC_002935.2 254456 255157 R Similar to Klebsiella pneumoniae phosphate regulon transcriptional regulatory protein PhoB SW:PHOB_KLEPN (P45605) (229 aa) fasta scores: E(): 1.7e-25, 40.708% id in 226 aa, to Shigella dysenteriae phosphate regulon transcriptional regulatory protein PhoB SW:PHOB_SHIDY (P45606) (229 aa) fasta scores: E(): 6.5e-25, 40.265% id in 226 aa, and to Escherichia coli phosphate regulon transcriptional regulatory protein PhoB or B0399 or Z0497 or ECS0449 SW:PHOB_ECOLI (P08402) (229 aa) fasta scores: E(): 6.5e-25, 40.265% id in 226 aa; two-component regulatory protein complement(254456..255157) Corynebacterium diphtheriae NCTC 13129 2649547 NP_938675.1 CDS DIP0287 NC_002935.2 255150 255947 R Similar to Escherichia coli sensor protein RcsC or B2218 SW:RCSC_ECOLI (P14376) (933 aa) fasta scores: E(): 5.5e-10, 26.339% id in 224 aa, and to Pseudomonas syringae sensor protein GacS or LemA SW:GACS_PSESY (P48027) (907 aa) fasta scores: E(): 2e-09, 27.530% id in 247 aa; two-component sensor protein complement(255150..255947) Corynebacterium diphtheriae NCTC 13129 2650421 NP_938676.1 CDS DIP0288 NC_002935.2 256103 256405 R subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport; monovalent cation/H+ antiporter subunit G complement(256103..256405) Corynebacterium diphtheriae NCTC 13129 2650422 NP_938677.1 CDS DIP0289 NC_002935.2 256405 256671 R subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; monovalent cation/H+ antiporter subunit F complement(256405..256671) Corynebacterium diphtheriae NCTC 13129 2650423 NP_938678.1 CDS DIP0290 NC_002935.2 256671 257048 R subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; monovalent cation/H+ antiporter subunit E complement(256671..257048) Corynebacterium diphtheriae NCTC 13129 2650424 NP_938679.1 CDS DIP0291 NC_002935.2 257051 258574 R subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone; monovalent cation/H+ antiporter subunit D complement(257051..258574) Corynebacterium diphtheriae NCTC 13129 2650425 NP_938680.1 CDS DIP0292 NC_002935.2 258574 258999 R subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; monovalent cation/H+ antiporter subunit C complement(258574..258999) Corynebacterium diphtheriae NCTC 13129 2650638 NP_938681.1 CDS DIP0293 NC_002935.2 259003 261915 R subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; monovalent cation/H+ antiporter subunit A complement(259003..261915) Corynebacterium diphtheriae NCTC 13129 2650639 NP_938682.1 CDS DIP0294 NC_002935.2 262085 263482 D Similar to Deinococcus radiodurans conserved hypothetical protein DR0075 TR:Q9RY75 (EMBL:AE001870) (1467 aa) fasta scores: E(): 3e-06, 27.568% id in 370 aa; hypothetical protein 262085..263482 Corynebacterium diphtheriae NCTC 13129 2648773 NP_938683.1 CDS DIP0295 NC_002935.2 263559 264449 R hypothetical protein complement(263559..264449) Corynebacterium diphtheriae NCTC 13129 2648774 NP_938684.1 CDS DIP0296 NC_002935.2 264827 265741 R Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT3785 TR:AAK48152 (EMBL:AE007176) (319 aa) fasta scores: E(): 1.6e-59, 54.08% id in 294 aa; hypothetical protein complement(264827..265741) Corynebacterium diphtheriae NCTC 13129 2648776 NP_938685.1 CDS DIP0297 NC_002935.2 265769 266233 D Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT3790 TR:AAK48157 (EMBL:AE007176) (154 aa) fasta scores: E(): 2e-23, 57.14% id in 154 aa; hypothetical protein 265769..266233 Corynebacterium diphtheriae NCTC 13129 2648900 NP_938686.1 CDS DIP0298 NC_002935.2 266238 268622 R Similar to Mycobacterium leprae Pbp1 Pon1 SWALL:P72351 (EMBL:S82044) (821 aa) fasta scores: E(): 4.9e-130, 48.08% id in 757 aa, and to Mycobacterium tuberculosis CDC1551 penicillin-binding protein 1 MT3784 TR:AAK48151 (EMBL:AE007176) (810 aa) fasta scores: E(): 4.8e-134, 48.75% id in 761 aa; penicillin-binding secreted protein complement(266238..268622) Corynebacterium diphtheriae NCTC 13129 2648901 NP_938687.1 CDS DIP0299 NC_002935.2 268821 269168 D Similar to Mycobacterium tuberculosis regulatory protein Rv681c or MTV025.029c TR:O69649 (EMBL:AL022121) (100 aa) fasta scores: E(): 4.9e-22, 65.06% id in 83 aa, and to Mycobacterium tuberculosis CDC1551 WhiB-related protein MT3783 TR:AAK48150 (EMBL:AE007176) (118 aa) fasta scores: E(): 5.6e-22, 65.06% id in 83 aa; regulatory protein 268821..269168 Corynebacterium diphtheriae NCTC 13129 2648902 NP_938688.1 CDS DIP0300 NC_002935.2 269209 269364 D Similar to Streptomyces coelicolor hypothetical 6.1 kDa protein SCH17.10c TR:Q9XA37 (EMBL:AL079353) (53 aa) fasta scores: E(): 5.4e-16, 85.71% id in 49 aa, and to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT3780 TR:AAK48147 (EMBL:AE007175) (53 aa) fasta scores: E(): 5.9e-14, 77.08% id in 48 aa; hypothetical protein 269209..269364 Corynebacterium diphtheriae NCTC 13129 2648903 NP_938689.1 CDS DIP0301 NC_002935.2 269366 269830 D Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT3779 TR:AAK48146 (EMBL:AE007175) (151 aa) fasta scores: E(): 1.3e-30, 63.75% id in 149 aa, and to Streptomyces coelicolor hypothetical 15.7 kDa protein SCH17.09c TR:Q9XA38 (EMBL:AL079353) (155 aa) fasta scores: E(): 2.5e-29, 62.25% id in 151 aa; hypothetical protein 269366..269830 Corynebacterium diphtheriae NCTC 13129 2648904 NP_938690.1 CDS DIP0302 NC_002935.2 269881 270705 D Similar to Mycobacterium tuberculosis hydrolase Rv3677c or MTV025.025c TR:O69645 (EMBL:AL022121) (264 aa) fasta scores: E(): 1.1e-18, 40.89% id in 269 aa; hydrolase 269881..270705 Corynebacterium diphtheriae NCTC 13129 2648905 NP_938691.1 CDS DIP0303 NC_002935.2 270766 271449 R Similar to Corynebacterium glutamicum probable transcription regulator TR:AAK58838 (EMBL:AF293334) (227 aa) fasta scores: E(): 8e-79, 91.18% id in 227 aa, and to Escherichia coli catabolite gene activator Crp or Cap or Csm or B3357 or Z4718 or ECS4208 SW:CRP_ECOLI (P03020) (210 aa) fasta scores: E(): 4.6e-15, 33.68% id in 190 aa; transcriptional regulator complement(270766..271449) Corynebacterium diphtheriae NCTC 13129 2648906 NP_938692.1 CDS nth NC_002935.2 271954 272709 D Similar to Mycobacterium tuberculosis endonuclease III Nth or Rv3674c or MT3775 or MTV025.022c SW:END3_MYCTU (O69642) (245 aa) fasta scores: E(): 2.2e-59, 62.04% id in 245 aa, and to Bacillus subtilis probable endonuclease III Nth or JooB SW:END3_BACSU (P39788) (219 aa) fasta scores: E(): 1.4e-28, 41.96% id in 193 aa; endonuclease III 271954..272709 Corynebacterium diphtheriae NCTC 13129 2650640 NP_938693.1 CDS DIP0305 NC_002935.2 272702 273262 D Similar to Mycobacterium tuberculosis CDC1551 thioredoxin-related protein MT3774 TR:AAK48141 (EMBL:AE007175) (227 aa) fasta scores: E(): 7.6e-13, 32.84% id in 204 aa; hypothetical protein 272702..273262 Corynebacterium diphtheriae NCTC 13129 2650641 NP_938694.1 CDS DIP0306 NC_002935.2 273265 274002 D Similar to Streptomyces coelicolor hypothetical 26.5 kDa protein SCH17.02c TR:Q9XA45 (EMBL:AL079353) (247 aa) fasta scores: E(): 1.9e-26, 40.08% id in 227 aa; hypothetical protein 273265..274002 Corynebacterium diphtheriae NCTC 13129 2650642 NP_938695.1 CDS DIP0307 NC_002935.2 274025 275221 D Similar to Mycobacterium tuberculosis CDC1551 serine protease MT3772 TR:AAK48139 (EMBL:AE007175) (397 aa) fasta scores: E(): 1.5e-47, 38.19% id in 398 aa; serine protease (mycosin) 274025..275221 Corynebacterium diphtheriae NCTC 13129 2650643 NP_938696.1 CDS DIP0308 NC_002935.2 275218 276156 R Similar to Streptomyces coelicolor hydrolase SCH5.29 TR:Q9X931 (EMBL:AL035636) (324 aa) fasta scores: E(): 5.8e-17, 31.21% id in 330 aa; hydrolase complement(275218..276156) Corynebacterium diphtheriae NCTC 13129 2650644 NP_938697.1 CDS DIP0309 NC_002935.2 276244 276765 R Similar to Mycobacterium tuberculosis hypothetical 18.9 kDa protein Rv3669 or MTV025.017 TR:O69637 (EMBL:AL022121) (172 aa) fasta scores: E(): 1.8e-20, 51.85% id in 135 aa; hypothetical protein complement(276244..276765) Corynebacterium diphtheriae NCTC 13129 2648740 NP_938698.1 CDS DIP0310 NC_002935.2 276872 277525 D Similar to Mycobacterium tuberculosis hypothetical 26.4 kDa protein Rv3662c or MTV025.010c TR:O69630 (EMBL:AL022121) (256 aa) fasta scores: E(): 3.1e-07, 31.44% id in 229 aa; hypothetical protein 276872..277525 Corynebacterium diphtheriae NCTC 13129 2648741 NP_938699.1 CDS DIP0311 NC_002935.2 277463 278368 R Similar to Mycobacterium tuberculosis hypothetical 30.7 kDa protein Rv3661 or MT3761 or MTV025.009 SW:Y0G1_MYCTU (O69629) (287 aa) fasta scores: E(): 2.2e-40, 45.22% id in 272 aa, and to Streptomyces coelicolor morphological differentiation-associated protein SCH5.21 TR:Q9X923 (EMBL:AL035636) (268 aa) fasta scores: E(): 5e-38, 45.8% id in 262 aa; hypothetical protein complement(277463..278368) Corynebacterium diphtheriae NCTC 13129 2648742 NP_938700.1 CDS DIP0312 NC_002935.2 278791 279828 D Similar to Mycobacterium tuberculosis hypothetical 35.8 kDa protein Rv3660c or MT3760 or MTV25.008c TR:O69628 (EMBL:AL022121) (350 aa) fasta scores: E(): 9.7e-19, 30.29% id in 340 aa, and to Streptomyces cyaneus (Streptomyces curacoi) inhibition of morphological differentiation TR:O33612 (EMBL:AB004855) (370 aa) fasta scores: E(): 1.6e-13, 33.08% id in 266 aa; morphological differentiation-like protein 278791..279828 Corynebacterium diphtheriae NCTC 13129 2648743 NP_938701.1 CDS DIP0313 NC_002935.2 279821 280918 D Similar to Mycobacterium tuberculosis hypothetical 36.7 kDa protein Rv3659c or MTV025.007c TR:O69627 (EMBL:AL022121) (352 aa) fasta scores: E(): 6.7e-51, 52.21% id in 316 aa; hypothetical protein 279821..280918 Corynebacterium diphtheriae NCTC 13129 2648744 NP_938702.1 CDS DIP0314 NC_002935.2 280915 281661 D Similar to Mycobacterium tuberculosis transmembrane protein Rv3658c or MTV025.006c TR:O69626 (EMBL:AL022121) (266 aa) fasta scores: E(): 6.1e-17, 36.52% id in 230 aa; hypothetical protein 280915..281661 Corynebacterium diphtheriae NCTC 13129 2648745 NP_938703.1 CDS DIP0315 NC_002935.2 281661 282239 D Similar to Mycobacterium tuberculosis hypothetical 19.1 kDa protein Rv3657c or MTV025.005c TR:O69625 (EMBL:AL022121) (191 aa) fasta scores: E(): 2.9e-10, 36.66% id in 150 aa; hypothetical protein 281661..282239 Corynebacterium diphtheriae NCTC 13129 2648746 NP_938704.1 CDS DIP0316 NC_002935.2 282263 282460 D Similar to Mycobacterium tuberculosis hypothetical 7.1 kDa protein Rv3656c or MTV025.004c TR:O69624 (EMBL:AL022121) (68 aa) fasta scores: E(): 2.6e-05, 43.33% id in 60 aa; hypothetical protein 282263..282460 Corynebacterium diphtheriae NCTC 13129 2648747 NP_938705.1 CDS DIP0317 NC_002935.2 282457 282732 D Similar to Mycobacterium tuberculosis hypothetical 13.0 kDa protein Rv3655c or MTV025.003c TR:O69623 (EMBL:AL022121) (125 aa) fasta scores: E(): 1.4, 31.81% id in 66 aa; hypothetical protein 282457..282732 Corynebacterium diphtheriae NCTC 13129 2649489 NP_938706.1 CDS DIP0318 NC_002935.2 282729 283055 D Similar to the central region of Streptomyces coelicolor membrane spanning protein SCH5.14c TR:Q9X916 (EMBL:AL035636) (230 aa) fasta scores: E(): 2.6e-05, 35.23% id in 105 aa; hypothetical protein 282729..283055 Corynebacterium diphtheriae NCTC 13129 2649490 NP_938707.1 CDS DIP0319 NC_002935.2 283045 285381 R Similar to Mycobacterium tuberculosis CDC1551 ATP-dependent RNA helicase, DeaD/DeaH box family MT3751 TR:AAK48112 (EMBL:AE007173) (771 aa) fasta scores: E(): 1.3e-152, 54.73% id in 760 aa, and to Bacillus subtilis helicase YprA SW:YPRA_BACSU (P50830) (749 aa) fasta scores: E(): 4.7e-67, 34.86% id in 763 aa; ATP-dependent RNA helicase complement(283045..285381) Corynebacterium diphtheriae NCTC 13129 2649491 NP_938708.1 CDS cspA NC_002935.2 285652 285855 D Similar to Mycobacterium smegmatis cold-shock protein CspA TR:Q9KGW0 (EMBL:AF281675) (67 aa) fasta scores: E(): 5.8e-23, 86.56% id in 67 aa; cold-shock protein 285652..285855 Corynebacterium diphtheriae NCTC 13129 2649659 NP_938709.1 CDS DIP0321 NC_002935.2 286029 286646 D Similar to Streptomyces coelicolor ABC transporter ATP-binding protein SC4A2.02c TR:O86658 (EMBL:AL031182) (229 aa) fasta scores: E(): 6.7e-12, 39.3% id in 201 aa; ABC transporter ATP-binding protein 286029..286646 Corynebacterium diphtheriae NCTC 13129 2649492 NP_938710.1 CDS DIP0322 NC_002935.2 286643 287350 D Similar to Escherichia coli hypothetical ABC transporter ATP-binding protein YddO or B1483 SW:YDDO_ECOLI (P77622) (308 aa) fasta scores: E(): 1.7e-15, 36.36% id in 209 aa; ABC transporter ATP-binding protein 286643..287350 Corynebacterium diphtheriae NCTC 13129 2649493 NP_938711.1 CDS DIP0323 NC_002935.2 287347 288594 D Similar to Streptomyces coelicolor transport system permease sc4g2.20 TR:O86692 (EMBL:AL031371) (436 aa) fasta scores: E(): 4.5e-47, 42.61% id in 406 aa; ABC transporter 287347..288594 Corynebacterium diphtheriae NCTC 13129 2649674 NP_938712.1 CDS DIP0324 NC_002935.2 288591 290078 D Similar to Streptomyces coelicolor solute-binding lipoprotein SC4G2.18 TR:O86690 (EMBL:AL031371) (503 aa) fasta scores: E(): 1.3e-64, 39.63% id in 497 aa; hypothetical protein 288591..290078 Corynebacterium diphtheriae NCTC 13129 2649675 NP_938713.1 CDS DIP0325 NC_002935.2 290085 291839 D Similar to Streptomyces coelicolor transport system permease SC4G2.19 TR:O86691 (EMBL:AL031371) (601 aa) fasta scores: E(): 1.9e-62, 37.01% id in 570 aa; transport system membrane protein 290085..291839 Corynebacterium diphtheriae NCTC 13129 2649676 NP_938714.1 CDS DIP0326 NC_002935.2 291817 293310 R Similar to Streptomyces coelicolor oxidoreductase SCF43A.31 TR:Q9XA84 (EMBL:AL096837) (520 aa) fasta scores: E(): 7.8e-84, 44.21% id in 484 aa; hypothetical protein complement(291817..293310) Corynebacterium diphtheriae NCTC 13129 2649677 NP_938715.1 CDS topA NC_002935.2 293451 296345 D catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 293451..296345 Corynebacterium diphtheriae NCTC 13129 2649678 NP_938716.1 CDS DIP0328 NC_002935.2 296265 297290 R Similar to Streptococcus pneumoniae Pap2 family protein SP0489 TR:AAK74647 (EMBL:AE007360) (216 aa) fasta scores: E(): 2.3e-06, 30.43% id in 207 aa; hypothetical protein complement(296265..297290) Corynebacterium diphtheriae NCTC 13129 2649280 NP_938717.1 CDS DIP0329 NC_002935.2 297398 299374 R Similar to Mycobacterium tuberculosis CDC1551 opt family protein MT2465 TR:AAK46760 (EMBL:AE007086) (667 aa) fasta scores: E(): 3.6e-138, 61.18% id in 644 aa; OPT family protein. membrane protein complement(297398..299374) Corynebacterium diphtheriae NCTC 13129 2649281 NP_938718.1 CDS DIP0330 NC_002935.2 299461 301524 R C-terminal region similar to Micromonospora viridifaciens sialidase precursor NedA SW:NANH_MICVI (Q02834) (647 aa) fasta scores: E(): 1.8e-23, 34.24% id in 403 aa; hypothetical protein complement(299461..301524) Corynebacterium diphtheriae NCTC 13129 2649282 NP_938719.1 CDS DIP0331 NC_002935.2 301604 302503 D Similar to Klebsiella oxytoca YiaX1 TR:AAK69523 (EMBL:AF282849) (315 aa) fasta scores: E(): 4.4e-18, 31.94% id in 313 aa; hypothetical protein 301604..302503 Corynebacterium diphtheriae NCTC 13129 2649283 NP_938720.1 CDS DIP0332 NC_002935.2 302520 304046 R Similar to Mycobacterium tuberculosis CDC1551 adenylate cyclase, MT3748 TR:AAK48108 (EMBL:AE007173) (549 aa) fasta scores: E(): 5.4e-73, 42.99% id in 507 aa; adenylate cyclase complement(302520..304046) Corynebacterium diphtheriae NCTC 13129 2650453 NP_938721.1 CDS DIP0333 NC_002935.2 304045 305310 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 304045..305310 Corynebacterium diphtheriae NCTC 13129 2650454 NP_938722.1 CDS DIP0334 NC_002935.2 305695 305946 D hypothetical protein 305695..305946 Corynebacterium diphtheriae NCTC 13129 2650456 NP_938723.1 CDS DIP0335 NC_002935.2 306195 306602 D hypothetical protein 306195..306602 Corynebacterium diphtheriae NCTC 13129 2650457 NP_938724.1 CDS DIP0336 NC_002935.2 306606 306815 R Similar to Mycobacterium tuberculosis hypothetical 8.5 kDa protein Rv1055 or MTV017.08 TR:O53403 (EMBL:AL021897) (78 aa) fasta scores: E(): 0.00013, 45.16% id in 62 aa; hypothetical protein complement(306606..306815) Corynebacterium diphtheriae NCTC 13129 2650458 NP_938725.1 CDS DIP0337 NC_002935.2 306912 307370 R Low similarity to bacteriophage BIL309 Integrase Int TR:Q9AZR0 (EMBL:AF323670) (377 aa) fasta scores: E(): 0.45, 27.41% id in 124 aa; phage integrase complement(306912..307370) Corynebacterium diphtheriae NCTC 13129 2650459 NP_938726.1 CDS DIP0338 NC_002935.2 307437 307559 R hypothetical protein complement(307437..307559) Corynebacterium diphtheriae NCTC 13129 2650460 NP_938727.1 CDS DIP0339 NC_002935.2 307596 307805 R hypothetical protein complement(307596..307805) Corynebacterium diphtheriae NCTC 13129 2650461 NP_938728.1 CDS DIP0343 NC_002935.2 308897 309421 D hypothetical protein 308897..309421 Corynebacterium diphtheriae NCTC 13129 2650463 NP_938729.1 CDS DIP0344 NC_002935.2 309428 309568 D hypothetical protein 309428..309568 Corynebacterium diphtheriae NCTC 13129 2650464 NP_938730.1 CDS DIP0345 NC_002935.2 309574 309753 D hypothetical protein 309574..309753 Corynebacterium diphtheriae NCTC 13129 2650465 NP_938731.1 CDS DIP0346 NC_002935.2 309772 309933 D Similar to Escherichia coli transposase InsI for insertion sequence element IS30B/C/D (InsI1 or B0256) and (InsI2 or B1404) and (InsI3 or B4284) SW:INSI_ECOLI (P37246) (383 aa) fasta scores: E(): 0.72, 45.45% id in 44 aa; IS element tranposase (partial) 309772..309933 Corynebacterium diphtheriae NCTC 13129 2648858 NP_938732.1 CDS DIP0347 NC_002935.2 309946 310104 D hypothetical protein 309946..310104 Corynebacterium diphtheriae NCTC 13129 2648859 NP_938733.1 CDS DIP0348 NC_002935.2 310129 311286 R Similar to Neisseria meningitidis hypothetical protein NMB0459 TR:Q9K0V1 (EMBL:AE002402) (369 aa) fasta scores: E(): 1.8e-58, 45.47% id in 365 aa; hypothetical protein complement(310129..311286) Corynebacterium diphtheriae NCTC 13129 2648860 NP_938734.1 CDS DIP0349 NC_002935.2 311422 312120 D Similar to Streptomyces coelicolor DNA repair protein SCG20A.20c TR:Q9K3M0 (EMBL:AL360055) (216 aa) fasta scores: E(): 1.4e-27, 44.54% id in 220 aa, and to Escherichia coli alkylated DNA repair protein AlkB or AidD or B2212 SW:ALKB_ECOLI (P05050) (216 aa) fasta scores: E(): 5.6e-10, 32.46% id in 231 aa; alkylated DNA repair protein 311422..312120 Corynebacterium diphtheriae NCTC 13129 2648861 NP_938735.1 CDS DIP0350 NC_002935.2 312169 312993 R Similar to Streptomyces coelicolor hydrolase SCBAC14E8.01c TR:Q9ADJ8 (EMBL:AL590435) (228 aa) fasta scores: E(): 1.6e-05, 28.49% id in 186 aa; protease complement(312169..312993) Corynebacterium diphtheriae NCTC 13129 2648862 NP_938736.1 CDS DIP0351 NC_002935.2 313246 313617 D Low similarity to central part of Corynebacterium glutamicum replicase RepA TR:Q9EUN5 (EMBL:AF164956) (479 aa) fasta scores: E(): 1.8e-16, 56.86% id in 102 aa; plasmid replication protein 313246..313617 Corynebacterium diphtheriae NCTC 13129 2648863 NP_938737.1 CDS DIP0352 NC_002935.2 313721 313888 R Similar to Clostridium perfringens hypothetical 6.1 kDa protein SW:YPI8_CLOPE (P18018) (55 aa) fasta scores: E(): 1, 42.85% id in 35 aa; hypothetical protein complement(313721..313888) Corynebacterium diphtheriae NCTC 13129 2648864 NP_938738.1 CDS DIP0353 NC_002935.2 313903 314421 R Similar to N-terminal region of Streptococcus pneumoniae 3-hydroxy-3-methylglutaryl-CoA reductase SP1726 TR:AAK75803 (EMBL:AE007465) (424 aa) fasta scores: E(): 8.7, 26.38% id in 144 aa; hypothetical protein complement(313903..314421) Corynebacterium diphtheriae NCTC 13129 2648865 NP_938739.1 CDS DIP0356 NC_002935.2 315605 315754 R hypothetical protein complement(315605..315754) Corynebacterium diphtheriae NCTC 13129 2648867 NP_938740.1 CDS DIP0357 NC_002935.2 316102 323838 D C-terminal region Similar to Deinococcus radiodurans alpha-dextran endo-1,6-alpha-glucosidase DR0405 TR:Q9RXB0 (EMBL:AE001900) (910 aa) fasta scores: E(): 3.1e-110, 41.4% id in 942 aa, and N-terminal region similar to Streptomyces lividans alpha-amylase precursor Amy SW:AMY_STRLI (Q05884) (919 aa) fasta scores: E(): 1.4e-86, 41.56% id in 676 aa; bifunctional alpha-amylase/endo-alpha-glucosidase 316102..323838 Corynebacterium diphtheriae NCTC 13129 2648868 NP_938741.1 CDS DIP0358 NC_002935.2 323875 325527 R activates fatty acids by binding to coenzyme A; acyl-CoA synthetase complement(323875..325527) Corynebacterium diphtheriae NCTC 13129 2648869 NP_938742.1 CDS DIP0359 NC_002935.2 325657 326445 D Low similarity to Streptomyces scabies esterase precursor EstA SW:ESTA_STRSC (P22266) (345 aa) fasta scores: E(): 0.12, 26.28% id in 331 aa; secreted hydrolase 325657..326445 Corynebacterium diphtheriae NCTC 13129 2648870 NP_938743.1 CDS rfbA NC_002935.2 326409 327281 R Similar to Escherichia coli glucose-1-phosphate thymidylyltransferase RfbA SW:RBA2_ECOLI (P55253) (293 aa) fasta scores: E(): 1.5e-64, 59.93% id in 287 aa; glucose-1-phosphate thymidylyltransferase complement(326409..327281) Corynebacterium diphtheriae NCTC 13129 2648843 NP_938744.1 CDS DIP0361 NC_002935.2 327293 328639 R N-terminal region similar to Streptococcus pneumoniae dTDP-4-keto-6-deoxyglucose-3,5-epimerase CPS19AM TR:Q9Z642 (EMBL:AF105113) (197 aa) fasta scores: E(): 2.5e-29, 51.68% id in 178 aa, and C-terminal region to Serratia marcescens dTDP-L-rhamnose synthase RmlD TR:O52480 (EMBL:AF038816) (288 aa) fasta scores: E(): 6.7e-28, 38.79% id in 281 aa; bifunctional protein GlmU complement(327293..328639) Corynebacterium diphtheriae NCTC 13129 2648844 NP_938745.1 CDS rmlB NC_002935.2 328678 329685 R Similar to Mycobacterium leprae dTDP-(glucose or rhamnose)-4,6-dehydratase RmlB TR:Q9X7A3 (EMBL:AL049491) (331 aa) fasta scores: E(): 8.3e-84, 63.77% id in 334 aa; dTDP-(glucose or rhamnose)-4,6-dehydratase complement(328678..329685) Corynebacterium diphtheriae NCTC 13129 2648845 NP_938746.1 CDS DIP0363 NC_002935.2 329691 331043 R Similar to Streptomyces coelicolor metallopeptidase SCD95A.06c TR:Q9KXW8 (EMBL:AL357432) (473 aa) fasta scores: E(): 5.2e-42, 32.16% id in 457 aa; metallopeptidase complement(329691..331043) Corynebacterium diphtheriae NCTC 13129 2648846 NP_938747.1 CDS DIP0364 NC_002935.2 331040 333034 R Similar to Mycobacterium tuberculosis CDC1551 prolyl oligopeptidase MT0473 TR:AAK44697 (EMBL:AE006950) (673 aa) fasta scores: E(): 9.6e-118, 46.64% id in 671 aa; prolyl oligopeptidase complement(331040..333034) Corynebacterium diphtheriae NCTC 13129 2648847 NP_938748.1 CDS slpA NC_002935.2 333123 334190 R Similar to Corynebacterium ammoniagenes surface layer protein A SlpA TR:BAB62413 (EMBL:AB055224) (358 aa) fasta scores: E(): 1.4e-69, 52.76% id in 362 aa, and to Mycobacterium tuberculosis antigen 85-A precursor FbpA or MPT44 or Rv3804c or MT3911 or MTV026.09c SW:A85A_MYCTU (P17944) (338 aa) fasta scores: E(): 9.7e-18, 31.56% id in 320 aa; surface layer protein A complement(333123..334190) Corynebacterium diphtheriae NCTC 13129 2648848 NP_938749.1 CDS DIP0366 NC_002935.2 334217 334318 R Doubtful CDS. No significant database matches; hypothetical protein complement(334217..334318) Corynebacterium diphtheriae NCTC 13129 2648849 NP_938750.1 CDS DIP0367 NC_002935.2 334359 334622 R hypothetical protein complement(334359..334622) Corynebacterium diphtheriae NCTC 13129 2650450 NP_938751.1 CDS lpd NC_002935.2 334658 336067 D E3 component of alpha keto acid dehydrogenase complexes LpdC; forms a homodimer; binds one molecule of FAD monomer; catalyzes NAD+-dependent oxidation of dihydrolipoyl cofactors that are covalently linked to the E2 component; dihydrolipoamide dehydrogenase 334658..336067 Corynebacterium diphtheriae NCTC 13129 2650451 NP_938752.1 CDS DIP0369 NC_002935.2 336275 337699 R Similar to Mycobacterium tuberculosis CDC1551 DNA-binding protein, MT0481 TR:AAK44705 (EMBL:AE006950) (474 aa) fasta scores: E(): 2.8e-101, 55.34% id in 477 aa; regulatory protein complement(336275..337699) Corynebacterium diphtheriae NCTC 13129 2650452 NP_938753.1 CDS DIP0370 NC_002935.2 338150 338908 D Low similarity to Bacillus pseudofirmus succinate dehydrogenease cytochrome B-558 subunit DhsC SWALL:O54447 (EMBL:U91843) (159 aa) fasta scores: E(): 0.011, 28.22% id in 163 aa, and to Streptomyces coelicolor cytochrome B subunit SCM10.12c TR:Q9RCY6 (EMBL:AL133469) (243 aa) fasta scores: E(): 1.8e-18, 36.01% id in 236 aa; succinate dehydrogenease cytochrome B subunit 338150..338908 Corynebacterium diphtheriae NCTC 13129 2648883 NP_938754.1 CDS sdhA NC_002935.2 338927 340942 D part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 338927..340942 Corynebacterium diphtheriae NCTC 13129 2648884 NP_938755.1 CDS DIP0372 NC_002935.2 340942 341691 D catalyzes the reversible formation of fumarate and ubiquinol from succinate and ubiquinone; succinate dehydrogenase/fumarate reductase iron-sulfur subunit 340942..341691 Corynebacterium diphtheriae NCTC 13129 2648885 NP_938756.1 CDS DIP0373 NC_002935.2 341769 342119 D hypothetical protein 341769..342119 Corynebacterium diphtheriae NCTC 13129 2648886 NP_938757.1 CDS DIP0374 NC_002935.2 342204 342299 D hypothetical protein 342204..342299 Corynebacterium diphtheriae NCTC 13129 2648887 NP_938758.1 CDS DIP0375 NC_002935.2 342318 343586 D Similar to Mycobacterium tuberculosis membrane protein Rv0473 or MTV038.17 TR:O53758 (EMBL:AL021933) (456 aa) fasta scores: E(): 2.5e-69, 44.47% id in 416 aa; hypothetical protein 342318..343586 Corynebacterium diphtheriae NCTC 13129 2648888 NP_938759.1 CDS DIP0376 NC_002935.2 343599 343874 D Similar to Streptomyces coelicolor membrane protein 2SCD46.14 TR:Q9FCG9 (EMBL:AL391406) (113 aa) fasta scores: E(): 0.0064, 32.14% id in 84 aa; hypothetical protein 343599..343874 Corynebacterium diphtheriae NCTC 13129 2648889 NP_938760.1 CDS DIP0377 NC_002935.2 343881 344369 D hypothetical protein 343881..344369 Corynebacterium diphtheriae NCTC 13129 2648890 NP_938761.1 CDS DIP0378 NC_002935.2 344366 345109 R hypothetical protein complement(344366..345109) Corynebacterium diphtheriae NCTC 13129 2648891 NP_938762.1 CDS DIP0379 NC_002935.2 345115 345990 R Similar to Clostridium pasteurianum pyruvate formate-lyase ativating enzyme Act SW:PFLA_CLOPA (Q46267) (238 aa) fasta scores: E(): 1.4e-32, 44.24% id in 226 aa, and to Escherichia coli pyruvate formate-lyase 1 activating enzyme PflA or Act or B0902 or Z1246 or ECS0985 SW:PFLA_ECOLI (P09374) (245 aa) fasta scores: E(): 1.1e-31, 38.68% id in 243 aa; oxidoreductase complement(345115..345990) Corynebacterium diphtheriae NCTC 13129 2648892 NP_938763.1 CDS DIP0382 NC_002935.2 348818 349630 R Similar to Streptomyces coelicolor hypothetical 29.8 kDa protein 2SCD46.17c TR:Q9FCG6 (EMBL:AL391406) (271 aa) fasta scores: E(): 3e-26, 47.92% id in 265 aa; hypothetical protein complement(348818..349630) Corynebacterium diphtheriae NCTC 13129 2648801 NP_938764.1 CDS DIP0383 NC_002935.2 349646 350107 R Low similarity to Mycobacterium tuberculosis hypothetical 19.1 kDa protein Rv0481c or MT0499 or MTCY20G9.07c SW:Y481_MYCTU (Q11147) (174 aa) fasta scores: E(): 0.028, 23.92% id in 163 aa; hypothetical protein complement(349646..350107) Corynebacterium diphtheriae NCTC 13129 2648802 NP_938765.1 CDS murB NC_002935.2 350143 351276 D catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 350143..351276 Corynebacterium diphtheriae NCTC 13129 2648803 NP_938766.1 CDS DIP0385 NC_002935.2 351273 351638 R Similar to Bacillus subtilis YjqA protein TR:O34593 (EMBL:Z99110) (125 aa) fasta scores: E(): 5e-11, 35.51% id in 107 aa; hypothetical protein complement(351273..351638) Corynebacterium diphtheriae NCTC 13129 2648804 NP_938767.1 CDS DIP0386 NC_002935.2 351641 353347 R activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase complement(351641..353347) Corynebacterium diphtheriae NCTC 13129 2648805 NP_938768.1 CDS DIP0387 NC_002935.2 353409 355109 R activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase complement(353409..355109) Corynebacterium diphtheriae NCTC 13129 2648806 NP_938769.1 CDS DIP0388 NC_002935.2 355193 356476 D Similar to Streptomyces coelicolor glycosyl transferase GlgA TR:Q9X9U5 (EMBL:AJ243803) (387 aa) fasta scores: E(): 3.5e-19, 29.88% id in 415 aa and to Mycobacterium leprae hypothetical 45.3 kDa protein ML2443 or U2168f or B2168_c2_201 SW:Y486_MYCLE (P54138) (428 aa) fasta scores: E(): 1.3e-73, 52.23% id in 402 aa; glycosyl transferase family protein 355193..356476 Corynebacterium diphtheriae NCTC 13129 2650670 NP_938770.1 CDS gpmA NC_002935.2 356496 357281 D 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 356496..357281 Corynebacterium diphtheriae NCTC 13129 2650671 NP_938771.1 CDS DIP0390 NC_002935.2 357293 358447 D Similar to Mycobacterium tuberculosis sensor-like histidine kinase SenX3 or Rv0490 or MT0509 or MTCY20G9.16 SW:SEX3_MYCTU (Q11155) (410 aa) fasta scores: E(): 3.6e-60, 48.84% id in 389 aa; two component system sensor kinase 357293..358447 Corynebacterium diphtheriae NCTC 13129 2650672 NP_938772.1 CDS regX3 NC_002935.2 358447 359127 D Similar to Mycobacterium tuberculosis sensory transduction protein RegX3 or Rv0491 or MT0510 or MTCY20G9.17 SW:RGX3_MYCTU (Q11156) (227 aa) fasta scores: E(): 4e-68, 80.97% id in 226 aa; two component system response regulator 358447..359127 Corynebacterium diphtheriae NCTC 13129 2650673 NP_938773.1 CDS DIP0392 NC_002935.2 359090 359959 R Similar to Mycobacterium tuberculosis hypothetical 32.9 kDa protein Rv0495c or MT0515 or MTCY20G9.21c SW:Y495_MYCTU (Q11160) (296 aa) fasta scores: E(): 3.6e-25, 44.07% id in 270 aa; hypothetical protein complement(359090..359959) Corynebacterium diphtheriae NCTC 13129 2650674 NP_938774.1 CDS DIP0393 NC_002935.2 360212 360835 D hypothetical protein 360212..360835 Corynebacterium diphtheriae NCTC 13129 2650675 NP_938775.1 CDS proC NC_002935.2 360869 361681 D catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase 360869..361681 Corynebacterium diphtheriae NCTC 13129 2650676 NP_938776.1 CDS DIP0395 NC_002935.2 361938 362129 D Similar to Mycobacterium leprae B2168_C1_172 ML2429 TR:Q49828 (EMBL:U00018) (86 aa) fasta scores: E(): 7.6e-16, 80% id in 55 aa; excisionase 361938..362129 Corynebacterium diphtheriae NCTC 13129 2650677 NP_938777.1 CDS DIP0396 NC_002935.2 362191 362418 D Similar to Mycobacterium tuberculosis and Mycobacterium leprae hypothetical 4.1 kDa protein Rv0500.1/ML2428.1 or Rv0500B or MT0521.1 or ML2428.1 or ML2428A SW:Y50A_MYCTU (Q9CB56) (33 aa) fasta scores: E(): 1.6e-08, 100% id in 33 aa; hypothetical protein 362191..362418 Corynebacterium diphtheriae NCTC 13129 2650200 NP_938778.1 CDS DIP0397 NC_002935.2 362497 363366 D Similar to Streptomyces coelicolor membrane protein SCBAC16H6.28 TR:CAC44607 (EMBL:AL596162) (270 aa) fasta scores: E(): 4.9e-22, 39.13% id in 207 aa; hypothetical protein 362497..363366 Corynebacterium diphtheriae NCTC 13129 2650201 NP_938779.1 CDS DIP0398 NC_002935.2 363332 364375 R Similar to Mycobacterium tuberculosis hypothetical 32.7 kDa protein Rv0505c or MT0526 or MTCY20G9.32c SW:Y505_MYCTU (Q11169) (308 aa) fasta scores: E(): 4.7e-52, 59.67% id in 243 aa; hypothetical protein complement(363332..364375) Corynebacterium diphtheriae NCTC 13129 2650202 NP_938780.1 CDS DIP0399 NC_002935.2 364441 364683 D Similar to Mycobacterium tuberculosis hypothetical 10.7 kDa protein Rv0508 or MT0529 or MTCY20G9.35 SW:Y508_MYCTU (Q11172) (97 aa) fasta scores: E(): 2.7e-08, 40.74% id in 81 aa; hypothetical protein 364441..364683 Corynebacterium diphtheriae NCTC 13129 2650203 NP_938781.1 CDS hemA NC_002935.2 364800 366116 D catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 364800..366116 Corynebacterium diphtheriae NCTC 13129 2650204 NP_938782.1 CDS hemC NC_002935.2 366113 366997 D transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 366113..366997 Corynebacterium diphtheriae NCTC 13129 2650205 NP_938783.1 CDS DIP0402 NC_002935.2 367058 368728 D Similar to Mycobacterium leprae possible uroporphyrin-III C-methyltransferase HemD or ML2420 TR:Q9CB60 (EMBL:AL583925) (563 aa) fasta scores: E(): 9.3e-91, 52.81% id in 551 aa; uroporphyrin-III C-methyltransferase 367058..368728 Corynebacterium diphtheriae NCTC 13129 2650206 NP_938784.1 CDS hemB NC_002935.2 368725 369717 D catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 368725..369717 Corynebacterium diphtheriae NCTC 13129 2650207 NP_938785.1 CDS DIP0404 NC_002935.2 369844 370155 R hypothetical protein complement(369844..370155) Corynebacterium diphtheriae NCTC 13129 2649504 NP_938786.1 CDS DIP0405 NC_002935.2 370197 372722 D Similar to Mycobacterium tuberculosis probable cation-transporting ATPase V CtpV or Rv0969 or MT0997 or MTCY10D7.05c SW:CTPV_MYCTU (P77894) (770 aa) fasta scores: E(): 4.5e-29, 27.6% id in 797 aa; cation transport protein 370197..372722 Corynebacterium diphtheriae NCTC 13129 2649505 NP_938787.1 CDS DIP0406 NC_002935.2 372700 373818 R Low similarity to Bacillus halodurans BH0756 protein TR:Q9KEU3 (EMBL:AP001509) (410 aa) fasta scores: E(): 1.4e-07, 23.95% id in 405 aa; hypothetical protein complement(372700..373818) Corynebacterium diphtheriae NCTC 13129 2649506 NP_938788.1 CDS hemE NC_002935.2 373884 374918 D catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 373884..374918 Corynebacterium diphtheriae NCTC 13129 2649507 NP_938789.1 CDS hemG NC_002935.2 374934 376286 D catalyzes the formation of protoporphyrin IX from protoporphyrinogen IX; protoporphyrinogen oxidase 374934..376286 Corynebacterium diphtheriae NCTC 13129 2649508 NP_938790.1 CDS hemL NC_002935.2 376342 377634 D Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 376342..377634 Corynebacterium diphtheriae NCTC 13129 2649362 NP_938791.1 CDS DIP0410 NC_002935.2 377631 378239 D Similar to Streptomyces coelicolor phosphoglycerate mutase SCD65.13 TR:Q9F2R9 (EMBL:AL392176) (233 aa) fasta scores: E(): 1.5e-35, 50.25% id in 199 aa and low similarity to Escherichia coli probable phosphoglycerate mutase 2 GpmB or B4395 or Z5997 or ECS5353 SW:PMG2_ECOLI (P36942) (215 aa) fasta scores: E(): 8.5e-06, 25.96% id in 181 aa; phosphoglycerate mutase 377631..378239 Corynebacterium diphtheriae NCTC 13129 2649363 NP_938792.1 CDS DIP0411 NC_002935.2 378240 378800 D Similar to Deinococcus radiodurans thiol:disulfide interchange protein DR0189 TR:Q9RXW6 (EMBL:AE001881) (185 aa) fasta scores: E(): 7.1e-09, 34.84% id in 132 aa, and to Bacillus halodurans thioredoxin BH1522 TR:Q9KCP7 (EMBL:AP001512) (177 aa) fasta scores: E(): 3.4e-08, 34.12% id in 126 aa and to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT0548 TR:AAK44771 (EMBL:AE006954) (216 aa) fasta scores: E(): 9.2e-31, 48.95% id in 192 aa; electron transport-like protein 378240..378800 Corynebacterium diphtheriae NCTC 13129 2649364 NP_938793.1 CDS DIP0412 NC_002935.2 378797 379588 D Similar to Mycobacterium leprae B2168_C1_192 ML2411 TR:Q49810 (EMBL:U00018) (262 aa) fasta scores: E(): 8.6e-46, 53.2% id in 250 aa; cytochrome C biogenesis protein 378797..379588 Corynebacterium diphtheriae NCTC 13129 2649365 NP_938794.1 CDS DIP0413 NC_002935.2 379597 381189 D Similar to Mycobacterium tuberculosis hypothetical 57.1 kDa protein Rv0528 or MTCY25D10.07 TR:O06394 (EMBL:Z95558) (529 aa) fasta scores: E(): 3.9e-103, 49.43% id in 532 aa; hypothetical protein 379597..381189 Corynebacterium diphtheriae NCTC 13129 2648570 NP_938795.1 CDS DIP0414 NC_002935.2 381198 382097 D Similar to Mycobacterium tuberculosis CDC1551 cytochrome C assembly family protein MT0551 TR:AAK44774 (EMBL:AE006954) (324 aa) fasta scores: E(): 6.3e-54, 47.81% id in 320 aa; cytochrome C-like protein 381198..382097 Corynebacterium diphtheriae NCTC 13129 2648571 NP_938796.1 CDS DIP0415 NC_002935.2 382094 382363 R Similar to Streptomyces coelicolor ArsR-family transcriptional regulator SC4A9.07 TR:Q9L1V5 (EMBL:AL138668) (117 aa) fasta scores: E(): 7.2e-10, 44.57% id in 83 aa, and to Methanococcus jannaschii hypothetical protein MJ1325 TR:Q58721 (EMBL:U67573) (89 aa) fasta scores: E(): 5.1e-09, 42.16% id in 83 aa; ArsR family transcriptional regulator complement(382094..382363) Corynebacterium diphtheriae NCTC 13129 2648572 NP_938797.1 CDS DIP0416 NC_002935.2 382403 382591 R Low similarity to Mycobacterium tuberculosis CDC1551 hypothetical 6.1 kDa protein MT0553 TR:AAK44776 (EMBL:AE006954) (53 aa) fasta scores: E(): 4, 34.04% id in 47 aa; hypothetical protein complement(382403..382591) Corynebacterium diphtheriae NCTC 13129 2650527 NP_938798.1 CDS DIP0417 NC_002935.2 382590 382931 D Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT0554 TR:AAK44777 (EMBL:AE006954) (105 aa) fasta scores: E(): 3.1e-05, 35.8% id in 81 aa; hypothetical protein 382590..382931 Corynebacterium diphtheriae NCTC 13129 2650528 NP_938799.1 CDS menA NC_002935.2 382906 383769 R catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase complement(382906..383769) Corynebacterium diphtheriae NCTC 13129 2650529 NP_938800.1 CDS DIP0419 NC_002935.2 383911 385020 D Low similarity in parts to Mycobacterium tuberculosis hypothetical 58.9 kDa protein precursor Rv2100 or MT2160 or MTCY49.40 SW:YL00_MYCTU (Q10709) (550 aa) fasta scores: E(): 1.7e-06, 32.57% id in 132 aa; hypothetical protein 383911..385020 Corynebacterium diphtheriae NCTC 13129 2650530 NP_938801.1 CDS DIP0420 NC_002935.2 384980 386089 R Similar to Mycobacterium leprae O-succinylbenzoic acid-CoA ligase MenE or ML2257 TR:Q9CBB8 (EMBL:AL583924) (368 aa) fasta scores: E(): 7.1e-41, 43.71% id in 366 aa, and to Escherichia coli O-succinylbenzoic acid--CoA ligase MenE or B2260 SW:MENE_ECOLI (P37353) (451 aa) fasta scores: E(): 8.2e-14, 29.28% id in 379 aa; O-succinylbenzoic acid--CoA ligase complement(384980..386089) Corynebacterium diphtheriae NCTC 13129 2650531 NP_938802.1 CDS menB NC_002935.2 386100 386966 R catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase complement(386100..386966) Corynebacterium diphtheriae NCTC 13129 2650532 NP_938803.1 CDS menC NC_002935.2 386971 387933 D catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase 386971..387933 Corynebacterium diphtheriae NCTC 13129 2649095 NP_938804.1 CDS DIP0423 NC_002935.2 387917 389446 D SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase 387917..389446 Corynebacterium diphtheriae NCTC 13129 2649096 NP_938805.1 CDS DIP0424 NC_002935.2 389443 389835 D Similar to Mycobacterium tuberculosis hypothetical 18.7 kDa protein Rv0556 or MTCY25D10.35 TR:O06422 (EMBL:Z95558) (171 aa) fasta scores: E(): 1.2e-11, 42.14% id in 121 aa; hypothetical protein 389443..389835 Corynebacterium diphtheriae NCTC 13129 2649097 NP_938806.1 CDS DIP0425 NC_002935.2 389811 390836 D Similar to Agrobacterium tumefaciens Agr_C_4173p TR:AAK88039 (EMBL:AE008145) (363 aa) fasta scores: E(): 1.9e-22, 31.8% id in 305 aa; glycosyl transferase family protein 389811..390836 Corynebacterium diphtheriae NCTC 13129 2649098 NP_938807.2 CDS ubiE NC_002935.2 390814 391503 D Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 390814..391503 Corynebacterium diphtheriae NCTC 13129 2649099 NP_938808.1 CDS DIP0427 NC_002935.2 391490 392440 R Similar to Clostridium acetobutylicum lactate dehydrogenase CAC3552 TR:AAK81477 (EMBL:AE007851) (320 aa) fasta scores: E(): 1.6e-36, 38.6% id in 316 aa, and to Bacillus subtilis L-lactate dehydrogenase Ldh or LctE SW:LDH_BACSU (P13714) (320 aa) fasta scores: E(): 2.9e-25, 33.95% id in 324 aa; lactate dehydrogenase complement(391490..392440) Corynebacterium diphtheriae NCTC 13129 2649100 NP_938809.1 CDS DIP0428 NC_002935.2 392451 393653 R Similar to Mycobacterium leprae FAD-linked oxidoreductase ML2276 TR:Q9CBA6 (EMBL:AL583925) (408 aa) fasta scores: E(): 7.2e-61, 54.47% id in 391 aa; FAD-linked oxidoreductase complement(392451..393653) Corynebacterium diphtheriae NCTC 13129 2649101 NP_938810.1 CDS DIP0429 NC_002935.2 393735 394727 D Similar to Mycobacterium leprae polyprenyl diphosphate synthase component ML2277 TR:Q9CBA5 (EMBL:AL583925) (330 aa) fasta scores: E(): 1.6e-57, 51.69% id in 325 aa, and to Bacillus stearothermophilus heptaprenyl diphosphate synthase component II HepT or HepS-2 SW:HEP2_BACST (P55785) (320 aa) fasta scores: E(): 9.6e-33, 38.99% id in 318 aa; polyprenyl diphosphate synthase component 393735..394727 Corynebacterium diphtheriae NCTC 13129 2650502 NP_938811.1 CDS secE NC_002935.2 395376 395744 D forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 395376..395744 Corynebacterium diphtheriae NCTC 13129 2650507 NP_938812.1 CDS nusG NC_002935.2 395838 396629 D Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 395838..396629 Corynebacterium diphtheriae NCTC 13129 2650508 NP_938813.1 CDS rplK NC_002935.2 396774 397202 D binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 396774..397202 Corynebacterium diphtheriae NCTC 13129 2650582 NP_938814.1 CDS rplA NC_002935.2 397269 397976 D in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 397269..397976 Corynebacterium diphtheriae NCTC 13129 2650583 NP_938815.1 CDS DIP0434 NC_002935.2 398031 398843 R Similar to Escherichia coli transposase InsK for insertion sequence element IS150 or B3558 SW:INSK_ECOLI (P19769) (283 aa) fasta scores: E(): 1.3e-42, 44.48% id in 263 aa. Identical to DIP1517, DIP1526, DIP1809 and DIP2123; transposase complement(398031..398843) Corynebacterium diphtheriae NCTC 13129 2650584 NP_938816.1 CDS DIP0435 NC_002935.2 398891 399373 R Similar to Streptococcus pneumoniae hypothetical 20.7 kDa protein TR:Q9KK22 (EMBL:AF154034) (171 aa) fasta scores: E(): 1.1e-07, 32.69% id in 156 aa, and to Yersinia pestis insertion element IS1661 DNA-binding protein YPO4046 TR:CAC93502 (EMBL:AJ414160) (171 aa) fasta scores: E(): 0.00096, 26.06% id in 165 aa. Identical to DIP1518, DIP1525, DIP1808 and DIP2124; insertion element DNA-binding protein complement(398891..399373) Corynebacterium diphtheriae NCTC 13129 2650585 NP_938817.1 CDS rplJ NC_002935.2 399728 400243 D binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 399728..400243 Corynebacterium diphtheriae NCTC 13129 2650586 NP_938818.1 CDS rplL NC_002935.2 400287 400667 D present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 400287..400667 Corynebacterium diphtheriae NCTC 13129 2650587 NP_938819.1 CDS DIP0438 NC_002935.2 400793 402262 D C-terminal similar to Bacillus halodurans surface adhesin A precursor PsaA or BH0516 TR:Q9KFG3 (EMBL:AP001508) (300 aa) fasta scores: E(): 2.9e-14, 34.09% id in 176 aa; hypothetical protein 400793..402262 Corynebacterium diphtheriae NCTC 13129 2650588 NP_938820.1 CDS DIP0439 NC_002935.2 402263 403159 D No significant database matches. Note: Also presents similarities with DIP1724, DIP0442, DIP2325 and DIP0443; hypothetical protein 402263..403159 Corynebacterium diphtheriae NCTC 13129 2650589 NP_938821.1 CDS DIP0440 NC_002935.2 403152 403880 D Similar to Deinococcus radiodurans manganese ABC transporter, ATP-binding protein, DR2284 TR:Q9RS43 (EMBL:AE002060) (239 aa) fasta scores: E(): 5.3e-25, 39.57% id in 235 aa; ABC transporter ATP-binding protein 403152..403880 Corynebacterium diphtheriae NCTC 13129 2649660 NP_938822.1 CDS DIP0441 NC_002935.2 403882 404745 D Similar to Streptococcus gordonii challis 29 kDa membrane protein in psaA 5'region SW:P29K_STRGC (P42361) (278 aa) fasta scores: E(): 3.8e-28, 38.25% id in 264 aa; hypothetical protein 403882..404745 Corynebacterium diphtheriae NCTC 13129 2649661 NP_938823.1 CDS DIP0442 NC_002935.2 404738 406720 D No significant database matches. Note: Also similar to DIP0439, DIP1724, DIP2325 and DIP0443; hypothetical protein 404738..406720 Corynebacterium diphtheriae NCTC 13129 2649662 NP_938824.1 CDS DIP0443 NC_002935.2 406738 407592 D No significant database matches. Note: Contains a potential sortase anchor site (LPDTG) upstream of the C-terminal region transmembrane domain. Also similar to DIP0439, DIP1724, DIP0442 and DIP2325; surface-anchored membrane protein 406738..407592 Corynebacterium diphtheriae NCTC 13129 2649663 NP_938825.1 CDS DIP0444 NC_002935.2 407597 408616 D No significant database matches. Contains a lysine rich region close to the C-terminal end; hypothetical protein 407597..408616 Corynebacterium diphtheriae NCTC 13129 2649664 NP_938826.1 CDS DIP0445 NC_002935.2 408621 409559 D Low similarity to Mycobacterium leprae integral membrane protein ML2581 TR:Q9CD18 (EMBL:AL583926) (427 aa) fasta scores: E(): 2.5, 24.7% id in 344 aa; hypothetical protein 408621..409559 Corynebacterium diphtheriae NCTC 13129 2649665 NP_938827.1 CDS rpoB NC_002935.2 409723 413250 D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 409723..413250 Corynebacterium diphtheriae NCTC 13129 2650616 NP_938828.1 CDS rpoC NC_002935.2 413298 417308 D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 413298..417308 Corynebacterium diphtheriae NCTC 13129 2650617 NP_938829.1 CDS DIP0448 NC_002935.2 417620 418336 R Similar to Streptomyces coelicolor ABC transport system ATP-binding protein SCE41.20c TR:Q9F2N9 (EMBL:AL442120) (262 aa) fasta scores: E(): 2.4e-29, 44.49% id in 236 aa; ABC transporter ATP-binding protein complement(417620..418336) Corynebacterium diphtheriae NCTC 13129 2650618 NP_938830.1 CDS DIP0449 NC_002935.2 418336 420009 R Low similarity to Staphylococcus aureus, ABC transporter VraE or SA2493 or SAV2702 TR:Q9KWJ6 (EMBL:AB035452) (626 aa) fasta scores: E(): 0.066, 21.03% id in 385 aa; ABC transporter inner membrane protein complement(418336..420009) Corynebacterium diphtheriae NCTC 13129 2650619 NP_938831.1 CDS DIP0450 NC_002935.2 420167 420643 D hypothetical protein 420167..420643 Corynebacterium diphtheriae NCTC 13129 2650620 NP_938832.1 CDS DIP0451 NC_002935.2 420648 420971 D hypothetical protein 420648..420971 Corynebacterium diphtheriae NCTC 13129 2650621 NP_938833.1 CDS DIP0452 NC_002935.2 421023 421292 R Low similarity to Corynebacterium jeikeium transposase A TnpA TR:AAK67709 (EMBL:AY036070) (105 aa) fasta scores: E(): 0.17, 32.63% id in 95 aa; transposase complement(421023..421292) Corynebacterium diphtheriae NCTC 13129 2650590 NP_938834.1 CDS DIP0455 NC_002935.2 426702 427061 R Low similarity to Pseudomonas aeruginosa probable transcriptional regulator PA3689 TR:Q9HXV1 (EMBL:AE004788) (156 aa) fasta scores: E(): 2.1, 34.34% id in 99 aa; hypothetical protein complement(426702..427061) Corynebacterium diphtheriae NCTC 13129 2650592 NP_938835.1 CDS DIP0456 NC_002935.2 427246 427710 R hypothetical protein complement(427246..427710) Corynebacterium diphtheriae NCTC 13129 2650593 NP_938836.1 CDS DIP0457 NC_002935.2 427803 428210 R hypothetical protein complement(427803..428210) Corynebacterium diphtheriae NCTC 13129 2650594 NP_938837.1 CDS cstS NC_002935.2 428385 429611 D Almost identical to already sequenced Corynebacterium diphtheriae histidine kinase CstS TR:Q9RPE8 (EMBL:AF161328) (408 aa) fasta scores: E(): 2e-149, 97.3% id in 408 aa; histidine kinase 428385..429611 Corynebacterium diphtheriae NCTC 13129 2650595 NP_938838.1 CDS cstA NC_002935.2 429616 430317 D Identical to previously sequenced Corynebacterium diphtheriae response regulator CstA TR:Q9RPE7 (EMBL:AF161328) (233 aa) fasta scores: E(): 4.9e-83, 99.57% id in 233 aa; response regulator 429616..430317 Corynebacterium diphtheriae NCTC 13129 2650596 NP_938839.1 CDS DIP0460 NC_002935.2 430344 431318 D Similar to Streptomyces coelicolor ABC transporter ATP-binding subunit 2SC6G5.39c TR:Q9K4B6 (EMBL:AL359152) (346 aa) fasta scores: E(): 9.6e-39, 44.02% id in 318 aa; ABC transporter ATP-binding protein 430344..431318 Corynebacterium diphtheriae NCTC 13129 2650597 NP_938840.1 CDS DIP0461 NC_002935.2 431339 432106 D Low similarity to Streptomyces coelicolor integral membrane protein SCBAC17A6.12c TR:CAC44657 (EMBL:AL596248) (387 aa) fasta scores: E(): 0.021, 30.04% id in 213 aa; ABC transporter inner membrane protein 431339..432106 Corynebacterium diphtheriae NCTC 13129 2648752 NP_938841.1 CDS DIP0462 NC_002935.2 432122 432793 D hypothetical protein 432122..432793 Corynebacterium diphtheriae NCTC 13129 2648753 NP_938842.1 CDS DIP0463 NC_002935.2 432790 433728 D Similar to Streptococcus pyogenes hypothetical protein SPY0576 TR:Q9A0X1 (EMBL:AE006514) (300 aa) fasta scores: E(): 2.3e-31, 36.93% id in 287 aa; hypothetical protein 432790..433728 Corynebacterium diphtheriae NCTC 13129 2648754 NP_938843.1 CDS DIP0464 NC_002935.2 433725 434228 R Low similarity to the central part of Alcaligenes eutrophus NrdG protein TR:Q9ZER3 (EMBL:AJ012479) (256 aa) fasta scores: E(): 6.4e-13, 37.5% id in 168 aa; hypothetical protein complement(433725..434228) Corynebacterium diphtheriae NCTC 13129 2648755 NP_938844.1 CDS DIP0465 NC_002935.2 434314 436098 R Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase complement(434314..436098) Corynebacterium diphtheriae NCTC 13129 2648756 NP_938845.1 CDS DIP0466 NC_002935.2 436256 436609 D hypothetical protein 436256..436609 Corynebacterium diphtheriae NCTC 13129 2648757 NP_938846.1 CDS rpsL NC_002935.2 436884 437255 D interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 436884..437255 Corynebacterium diphtheriae NCTC 13129 2648758 NP_938847.1 CDS rpsG NC_002935.2 437259 437726 D binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 437259..437726 Corynebacterium diphtheriae NCTC 13129 2649090 NP_938848.1 CDS fusA NC_002935.2 437925 440105 D EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 437925..440105 Corynebacterium diphtheriae NCTC 13129 2649091 NP_938849.1 CDS tuf NC_002935.2 440423 441613 D EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 440423..441613 Corynebacterium diphtheriae NCTC 13129 2649092 NP_938850.1 CDS DIP0471 NC_002935.2 441718 442248 D Similar to N-terminal region of Bacillus halodurans BH2297 protein TR:Q9KAJ0 (EMBL:AP001515) (232 aa) fasta scores: E(): 1.5e-08, 30.82% id in 146 aa; hypothetical protein 441718..442248 Corynebacterium diphtheriae NCTC 13129 2649093 NP_938851.1 CDS rpsJ NC_002935.2 442760 443065 D NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 442760..443065 Corynebacterium diphtheriae NCTC 13129 2649094 NP_938852.1 CDS rplC NC_002935.2 443098 443754 D binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 443098..443754 Corynebacterium diphtheriae NCTC 13129 2649032 NP_938853.1 CDS rplD NC_002935.2 443751 444404 D L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 443751..444404 Corynebacterium diphtheriae NCTC 13129 2649033 NP_938854.1 CDS rplW NC_002935.2 444404 444709 D binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 444404..444709 Corynebacterium diphtheriae NCTC 13129 2649034 NP_938855.1 CDS rplB NC_002935.2 444731 445573 D one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 444731..445573 Corynebacterium diphtheriae NCTC 13129 2649035 NP_938856.1 CDS rpsS NC_002935.2 445590 445868 D protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 445590..445868 Corynebacterium diphtheriae NCTC 13129 2649036 NP_938857.1 CDS rplV NC_002935.2 445872 446234 D binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 445872..446234 Corynebacterium diphtheriae NCTC 13129 2649037 NP_938858.1 CDS rpsC NC_002935.2 446234 446980 D forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 446234..446980 Corynebacterium diphtheriae NCTC 13129 2648548 NP_938859.1 CDS rplP NC_002935.2 446984 447400 D located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 446984..447400 Corynebacterium diphtheriae NCTC 13129 2648549 NP_938860.1 CDS rpmC NC_002935.2 447400 447630 D one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 447400..447630 Corynebacterium diphtheriae NCTC 13129 2648550 NP_938861.1 CDS rpsQ NC_002935.2 447633 447911 D primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 447633..447911 Corynebacterium diphtheriae NCTC 13129 2648551 NP_938862.1 CDS DIP0483 NC_002935.2 448082 449719 D C-terminal region presents los similarity to Streptococcus pneumoniae hypothetical protein SP0785 TR:AAK74922 (EMBL:AE007385) (399 aa) fasta scores: E(): 4e-08, 28.25% id in 315 aa; hypothetical protein 448082..449719 Corynebacterium diphtheriae NCTC 13129 2648552 NP_938863.1 CDS DIP0484 NC_002935.2 449736 450452 D Similar to Bacillus subtilis YknY protein TR:O31711 (EMBL:Z99111) (230 aa) fasta scores: E(): 3.2e-43, 57.01% id in 221 aa; ABC transporter ATP-binding protein 449736..450452 Corynebacterium diphtheriae NCTC 13129 2648553 NP_938864.1 CDS DIP0485 NC_002935.2 450449 451759 D Similar to Bacillus halodurans BH3121 protein TR:Q9K885 (EMBL:AP001517) (398 aa) fasta scores: E(): 4e-20, 33.33% id in 438 aa; ABC transporter inner membrane protein 450449..451759 Corynebacterium diphtheriae NCTC 13129 2648554 NP_938865.1 CDS rplN NC_002935.2 451955 452323 D binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 451955..452323 Corynebacterium diphtheriae NCTC 13129 2649533 NP_938866.1 CDS rplX NC_002935.2 452326 452640 D assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 452326..452640 Corynebacterium diphtheriae NCTC 13129 2649534 NP_938867.1 CDS rplE NC_002935.2 452643 453206 D part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 452643..453206 Corynebacterium diphtheriae NCTC 13129 2649535 NP_938868.1 CDS sdaC NC_002935.2 453909 455252 D Similar to Escherichia coli serine transporter SdaC or DcrA or B2796 or Z4113 or ECS3656 SW:SDAC_ECOLI (P36559) (429 aa) fasta scores: E(): 4.6e-100, 61.66% id in 420 aa; serine transporter 453909..455252 Corynebacterium diphtheriae NCTC 13129 2649536 NP_938869.1 CDS sdaA NC_002935.2 455277 456653 D Similar to Escherichia coli L-serine dehydratase 1 SdaA or B1814 SW:SDHL_ECOLI (P16095) (454 aa) fasta scores: E(): 4.8e-113, 63.08% id in 447 aa; L-serine dehydratase 1 455277..456653 Corynebacterium diphtheriae NCTC 13129 2649537 NP_938870.1 CDS DIP0491 NC_002935.2 456732 457760 D Similar to Mycobacterium leprae probable L-asparaginase AnsA or ML1198 or MLCB458.13c SW:ASPG_MYCLE (Q9X7E6) (310 aa) fasta scores: E(): 6.4e-18, 36.39% id in 305 aa, and to Erwinia chrysanthemi L-asparaginase precursor AnsB or Asn SW:ASPG_ERWCH (P06608) (348 aa) fasta scores: E(): 2.5e-11, 30.9% id in 330 aa. Also similar to DIP1587, 306 aa; fasta scores: E(): 1.1e-48, 52.303% identity in 304 aa overlap. Note: Contains a twin-arginine translocation (TAT) system recognition motif (RRSFLG) at the N-terminal region; secreted amino acid hydrolase 456732..457760 Corynebacterium diphtheriae NCTC 13129 2649538 NP_938871.1 CDS DIP0492 NC_002935.2 457757 458800 R ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase; molybdopterin biosynthesis protein MoeB complement(457757..458800) Corynebacterium diphtheriae NCTC 13129 2650523 NP_938872.1 CDS DIP0493 NC_002935.2 458800 459795 R N-terminal region similar to the C-terminal region of Synechococcus sp molybdenum cofactor biosynthesis protein CB MoaCB SW:MOCB_SYNP7 (Q56208) (319 aa) fasta scores: E(): 5.2e-09, 35.06% id in 154 aa and C-terminal region similar to Mycobacterium tuberculosis molybdopterin converting factor subunit 2 MoAE or Rv3119 or MT3201 or MTCY164.29 SWALL:MOAE_MYCTU (SWALL:O05795) (147 aa) fasta scores: E(): 5.7e-11, 38.97% id in 136 aa; bifunctional molybdopterim biosynthesis protein complement(458800..459795) Corynebacterium diphtheriae NCTC 13129 2650524 NP_938873.1 CDS DIP0494 NC_002935.2 460091 460834 R Similar to Mycobacterium tuberculosis CDC1551 hypothetical 24.2 kDa protein MT2696 TR:AAK47012 (EMBL:AE007102) (224 aa) fasta scores: E(): 1.3e-10, 31.37% id in 204 aa; hypothetical protein complement(460091..460834) Corynebacterium diphtheriae NCTC 13129 2650525 NP_938874.1 CDS DIP0495 NC_002935.2 460848 462713 R N-terminal region similar to Mycobacterium tuberculosis molybdenum transport system permease ModB or Rv1858 or MT1906 or MTCY359.15c SW:MODB_MYCTU (P95156) blast scores: E(): 2e-32, score: 353 37% id, and C-terminal region to Mycobacterium tuberculosis molybdenum transport ATP-binding protein ModC or Rv1859 or MT1907 or MTCY359.14 SW:MODC_MYCTU (P95155) blast scores: E(): 1e-17, score: 93 28% id; molybdenum ABC transporter ATP-binding protein complement(460848..462713) Corynebacterium diphtheriae NCTC 13129 2650526 NP_938875.1 CDS DIP0496 NC_002935.2 462759 463301 R Similar to part of Escherichia coli molybdate-binding periplasmic protein precursor ModA or B0763 SW:MODA_ECOLI (P37329) (257 aa) fasta scores: E(): 0.36, 31.6% id in 193 aa; molybdate binding protein (partial) complement(462759..463301) Corynebacterium diphtheriae NCTC 13129 2649063 NP_938876.1 CDS narI NC_002935.2 463533 464312 R Similar to Streptomyces coelicolor nitrate reductase gamma chain NarI TR:O86714 (EMBL:AL031515) (240 aa) fasta scores: E(): 1e-44, 49.78% id in 237 aa, and to Bacillus subtilis nitrate reductase gamma chain NarI SW:NARI_BACSU (P42177) (223 aa) fasta scores: E(): 6.2e-33, 42.27% id in 220 aa; nitrate reductase subunit gamma complement(463533..464312) Corynebacterium diphtheriae NCTC 13129 2649064 NP_938877.1 CDS DIP0498 NC_002935.2 464326 464955 R Similar to Streptomyces coelicolor nitrate reductase delta chain NarJ3 TR:Q9EWF5 (EMBL:AL451182) (220 aa) fasta scores: E(): 3e-20, 39.39% id in 198 aa, and to Bacillus subtilis nitrate reductase delta chain NarJ SW:NARJ_BACSU (P42178) (184 aa) fasta scores: E(): 1.9e-12, 29.14% id in 175 aa; nitrate reductase subunit delta complement(464326..464955) Corynebacterium diphtheriae NCTC 13129 2649065 NP_938878.1 CDS narH NC_002935.2 465007 466608 R Similar to Bacillus subtilis nitrate reductase beta chain NarH SW:NARH_BACSU (P42176) (487 aa) fasta scores: E(): 1.4e-114, 56.31% id in 499 aa; nitrate reductase subunit beta complement(465007..466608) Corynebacterium diphtheriae NCTC 13129 2649066 NP_938879.1 CDS narG NC_002935.2 466608 470330 R Similar to Escherichia coli respiratory nitrate reductase 1 alpha chain NarG or NarC or BisD or B1224 SW:NARG_ECOLI (P09152) (1246 aa) fasta scores: E(): 0, 46.16% id in 1237 aa; respiratory nitrate reductase 1 subunit alpha complement(466608..470330) Corynebacterium diphtheriae NCTC 13129 2649067 NP_938880.1 CDS DIP0501 NC_002935.2 470374 471705 R Similar to Thermus thermophilus Nark2 TR:Q9RA45 (EMBL:AJ237974) (443 aa) fasta scores: E(): 2e-79, 50.22% id in 448 aa, and to Escherichia coli nitrite extrusion protein 2 NarU or B1469 SW:NARU_ECOLI (P37758) (462 aa) fasta scores: E(): 1.2e-31, 33.47% id in 472 aa; nitrate/nitrite transport system integral membrane protein complement(470374..471705) Corynebacterium diphtheriae NCTC 13129 2649068 NP_938881.1 CDS narK NC_002935.2 472039 473337 R Similar to Thermus thermophilus NarK1 TR:Q9RA46 (EMBL:AJ237974) (435 aa) fasta scores: E(): 2e-64, 59.56% id in 418 aa, and to Escherichia coli nitrite extrusion protein 1 NarK or B1223 SW:NARK_ECOLI (P10903) (463 aa) fasta scores: E(): 5.2e-17, 27.63% id in 427 aa; nitrate/nitrite transport system integral membrane protein complement(472039..473337) Corynebacterium diphtheriae NCTC 13129 2649069 NP_938882.1 CDS DIP0503 NC_002935.2 473591 474085 D Similar to Streptomyces coelicolor molybdenum cofactor biosynthesis protein MoaB TR:Q9RKA9 (EMBL:AL132674) (179 aa) fasta scores: E(): 7.6e-12, 35.13% id in 148 aa; molybdenum cofactor biosynthesis protein 473591..474085 Corynebacterium diphtheriae NCTC 13129 2649102 NP_938883.1 CDS DIP0504 NC_002935.2 474082 474696 R Similar to Rhodobacter capsulatus molybdopterin-guanine dinucleotide biosynthesis protein A MobA SW:MOBA_RHOCA (Q9X7K0) (190 aa) fasta scores: E(): 6.3e-05, 29.53% id in 193 aa, and to Pseudomonas putida molybdopterin-guanine dinucleotide biosynthesis protein A MobA SW:MOBA_PSEPU (Q9WWW0) (191 aa) fasta scores: E(): 0.00032, 28.71% id in 195 aa; molybdopterin biosynthesis protein complement(474082..474696) Corynebacterium diphtheriae NCTC 13129 2649103 NP_938884.1 CDS moaC NC_002935.2 474674 475141 R Similar to Streptomyces coelicolor molybdenum cofactor biosynthesis protein MoaC TR:Q9RKA8 (EMBL:AL132674) (170 aa) fasta scores: E(): 2.5e-29, 55.92% id in 152 aa, and to Escherichia coli, and molybdenum cofactor biosynthesis protein C MoaC or ChlA3 or B0783 or Z1002 or ECS0861 SW:MOAC_ECOLI (P30747) (160 aa) fasta scores: E(): 1.9e-19, 47.74% id in 155 aa; molybdenum cofactor biosynthesis protein complement(474674..475141) Corynebacterium diphtheriae NCTC 13129 2649104 NP_938885.1 CDS DIP0506 NC_002935.2 475157 476383 R Similar to Escherichia coli molybdopterin biosynthesis protein MoeA or ChlE or BisB or NarE or B0827 SW:MOEA_ECOLI (P12281) (411 aa) fasta scores: E(): 3.9e-25, 32.82% id in 326 aa; molybdopterin biosynthesis protein complement(475157..476383) Corynebacterium diphtheriae NCTC 13129 2649105 NP_938886.1 CDS moaA NC_002935.2 476407 477438 R together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A complement(476407..477438) Corynebacterium diphtheriae NCTC 13129 2649106 NP_938887.1 CDS DIP0511 NC_002935.2 479270 480190 R Similar to Agrobacterium tumefaciens Agr_C_1883p TR:AAK86832 (EMBL:AE008033) (294 aa) fasta scores: E(): 3.5e-20, 31.69% id in 306 aa, and to Bacillus subtilis dihydrodipicolinate synthase DapA SW:DAPA_BACSU (Q04796) (290 aa) fasta scores: E(): 1.1e-15, 29.68% id in 283 aa; lysine biosynthesis protein complement(479270..480190) Corynebacterium diphtheriae NCTC 13129 2649108 NP_938888.1 CDS DIP0512 NC_002935.2 480224 481057 R Similar to Bacillus subtilis oligopeptide transport ATP-binding protein OppF or Spo0KE SW:OPPF_BACSU (P24137) (308 aa) fasta scores: E(): 1.7e-36, 48.51% id in 235 aa; oligopeptide ABC transporter ATP-binding protein complement(480224..481057) Corynebacterium diphtheriae NCTC 13129 2649109 NP_938889.1 CDS DIP0513 NC_002935.2 481063 483051 R C-terminal region similar to Salmonella typhimurium oligopeptide transport ATP-binding protein OppD or STM1743 SW:OPPD_SALTY (P04285) (335 aa) fasta scores: E(): 3.2e-38, 42.07% id in 328 aa, and N-terminal region to Bacillus firmus dipeptide transport system permease DppC SW:DPPC_BACFI (P94312) (304 aa) fasta scores: E(): 4.2e-32, 41.19% id in 267 aa; oligopeptide transport system (integral membrane and ATP-binding proteins) complement(481063..483051) Corynebacterium diphtheriae NCTC 13129 2648729 NP_938890.1 CDS DIP0514 NC_002935.2 483051 484016 R Similar to Bacillus subtilis oligopeptide transport system permease AppB SW:APPB_BACSU (P42062) (317 aa) fasta scores: E(): 4.6e-31, 34.7% id in 317 aa; oligopeptide transport system integral membrane protein complement(483051..484016) Corynebacterium diphtheriae NCTC 13129 2648730 NP_938891.1 CDS DIP0515 NC_002935.2 484258 485874 R Similar to Escherichia coli O157:H7 EDL933 transport protein Z1054 TR:AAG55204 (EMBL:AE005264) (512 aa) fasta scores: E(): 4.3e-19, 24% id in 479 aa. Note: Contains a twin-arginine translocation (TAT) system recognition motif (RRDFFK) at the N-terminal region; transport system secreted protein complement(484258..485874) Corynebacterium diphtheriae NCTC 13129 2648731 NP_938892.1 CDS DIP0516 NC_002935.2 485970 486158 D Doubtful CDS. No significant database matches; hypothetical protein 485970..486158 Corynebacterium diphtheriae NCTC 13129 2648732 NP_938893.1 CDS DIP0517 NC_002935.2 486216 486977 D Similar to Escherichia coli galactonate operon transcriptional repressor DgoR or B3694/B3695 SW:DGOR_ECOLI (P31460) (229 aa) fasta scores: E(): 8.4e-09, 23.11% id in 199 aa; GntR family transcriptional regulator 486216..486977 Corynebacterium diphtheriae NCTC 13129 2648733 NP_938894.1 CDS DIP0518 NC_002935.2 486974 487858 D Similar to Streptomyces coelicolor glucokinase Glk or SC6E10.20c SW:GLK_STRCO (P40184) (317 aa) fasta scores: E(): 8e-13, 30.91% id in 317 aa; regulatory protein sugar kinase 486974..487858 Corynebacterium diphtheriae NCTC 13129 2648734 NP_938895.1 CDS DIP0519 NC_002935.2 487887 488582 D Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 487887..488582 Corynebacterium diphtheriae NCTC 13129 2648735 NP_938896.1 CDS DIP0520 NC_002935.2 488618 489754 D Similar to Bacillus subtilis N-acetylglucosamine-6-phosphate deacetylase NagA SW:NAGA_BACSU (O34450) (396 aa) fasta scores: E(): 1.3e-23, 34.7% id in 389 aa, and to Escherichia coli, and N-acetylglucosamine-6-phosphate deacetylase NagA or B0677 or Z0824 or ECS0707 SW:NAGA_ECOLI (P15300) (382 aa) fasta scores: E(): 2.9e-18, 26.15% id in 390 aa; deacetylase 488618..489754 Corynebacterium diphtheriae NCTC 13129 2648736 NP_938897.1 CDS DIP0521 NC_002935.2 489788 490567 D Similar to Streptomyces coelicolor glucosamine phosphate isomerase SC7E4.33c TR:Q9K487 (EMBL:AL359214) (261 aa) fasta scores: E(): 5e-50, 54.44% id in 259 aa, and to Escherichia coli glucosamine-6-phosphate isomerase NagB or GlmD or B0678 or Z0825 or ECS0708 SW:NAGB_ECOLI (P09375) (266 aa) fasta scores: E(): 4.4e-32, 44.39% id in 223 aa; isomerase 489788..490567 Corynebacterium diphtheriae NCTC 13129 2648737 NP_938898.1 CDS DIP0522 NC_002935.2 490628 492664 R Similar to Streptomyces coelicolor hypothetical 48.2 kDa protein SCC75A.17c TR:Q9RKQ7 (EMBL:AL133220) (477 aa) fasta scores: E(): 4.8e-06, 25.21% id in 353 aa; hypothetical protein complement(490628..492664) Corynebacterium diphtheriae NCTC 13129 2648738 NP_938899.1 CDS DIP0523 NC_002935.2 492762 493763 R hypothetical protein complement(492762..493763) Corynebacterium diphtheriae NCTC 13129 2648739 NP_938900.1 CDS rpsH NC_002935.2 494228 494626 D binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 494228..494626 Corynebacterium diphtheriae NCTC 13129 2649679 NP_938901.1 CDS rplF NC_002935.2 494642 495178 D ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 494642..495178 Corynebacterium diphtheriae NCTC 13129 2649680 NP_938902.1 CDS rplR NC_002935.2 495220 495588 D binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 495220..495588 Corynebacterium diphtheriae NCTC 13129 2649681 NP_938903.1 CDS rpsE NC_002935.2 495629 496255 D located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 495629..496255 Corynebacterium diphtheriae NCTC 13129 2649682 NP_938904.1 CDS rpmD NC_002935.2 496259 496444 D L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 496259..496444 Corynebacterium diphtheriae NCTC 13129 2649683 NP_938905.1 CDS rplO NC_002935.2 496447 496893 D late assembly protein; 50S ribosomal protein L15 496447..496893 Corynebacterium diphtheriae NCTC 13129 2649684 NP_938906.1 CDS DIP0530 NC_002935.2 497070 497870 D Similar to Streptococcus pneumoniae transporter, FNT family, SP1215 TR:AAK75321 (EMBL:AE007421) (265 aa) fasta scores: E(): 1.4e-31, 42.24% id in 258 aa; transporter 497070..497870 Corynebacterium diphtheriae NCTC 13129 2649685 NP_938907.1 CDS DIP0531 NC_002935.2 497871 498605 R Similar to Mycobacterium tuberculosis FdhD protein homolog or Rv2899c or MT2967 or MTCY274.30c SW:FDHD_MYCTU (Q10820) (276 aa) fasta scores: E(): 0.0013, 28.34% id in 254 aa; hypothetical protein complement(497871..498605) Corynebacterium diphtheriae NCTC 13129 2649686 NP_938908.1 CDS DIP0532 NC_002935.2 498593 500293 R Similar to Streptomyces coelicolor alpha-glucosidase AglA TR:Q9KZ09 (EMBL:AL355752) (577 aa) fasta scores: E(): 2.2e-97, 48.09% id in 578 aa; amylase complement(498593..500293) Corynebacterium diphtheriae NCTC 13129 2649687 NP_938909.1 CDS DIP0533 NC_002935.2 500305 502095 R Similar to Bacillus coagulans oligo-1,6-glucosidase MalL SW:O16G_BACCO (Q45101) (555 aa) fasta scores: E(): 1.3e-26, 30.98% id in 539 aa; glycosylase complement(500305..502095) Corynebacterium diphtheriae NCTC 13129 2650533 NP_938910.1 CDS DIP0534 NC_002935.2 502322 503563 D Similar to Lactococcus lactis maltose ABC transporter substrate binding protein MalE TR:Q9CEZ8 (EMBL:AE006399) (410 aa) fasta scores: E(): 8.8e-35, 33.66% id in 407 aa; sugar-binding secreted protein 502322..503563 Corynebacterium diphtheriae NCTC 13129 2650271 NP_938911.1 CDS DIP0535 NC_002935.2 503681 505084 D Similar to Lactococcus lactis maltose ABC transporter permease MalF TR:Q9CEZ7 (EMBL:AE006399) (452 aa) fasta scores: E(): 9.4e-61, 39.15% id in 452 aa; sugar ABC transport system membrane protein 503681..505084 Corynebacterium diphtheriae NCTC 13129 2648818 NP_938912.1 CDS DIP0536 NC_002935.2 505084 505962 D Similar to Streptococcus pneumoniae maltodextrin transport system permease MalD or SP2110 SW:MALD_STRPN (Q04699) (277 aa) fasta scores: E(): 2.9e-21, 30.85% id in 282 aa; sugar ABC transport system membrane protein 505084..505962 Corynebacterium diphtheriae NCTC 13129 2648819 NP_938913.1 CDS DIP0537 NC_002935.2 506046 506768 D ABC transporter 506046..506768 Corynebacterium diphtheriae NCTC 13129 2648820 NP_938914.1 CDS DIP0538 NC_002935.2 506765 508018 R Similar to Streptomyces coelicolor hypothetical 46.2 kDa protein SC5F8.10c TR:Q9K4L4 (EMBL:AL357613) (410 aa) fasta scores: E(): 2.1e-74, 50% id in 394 aa; hypothetical protein complement(506765..508018) Corynebacterium diphtheriae NCTC 13129 2648821 NP_938915.1 CDS DIP0539 NC_002935.2 508133 509269 R Similar to Bacillus subtilis probable multiple sugar-binding transport ATP-binding protein MsmX SW:MSMX_BACSU (P94360) (365 aa) fasta scores: E(): 1.1e-54, 49.86% id in 367 aa; sugar ABC transport syste ATP-binding protein complement(508133..509269) Corynebacterium diphtheriae NCTC 13129 2648822 NP_938916.1 CDS secY NC_002935.2 509759 511081 D forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 509759..511081 Corynebacterium diphtheriae NCTC 13129 2648823 NP_938917.1 CDS adk NC_002935.2 511081 511626 D essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 511081..511626 Corynebacterium diphtheriae NCTC 13129 2650860 NP_938918.1 CDS mapA NC_002935.2 511740 512534 D catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase 511740..512534 Corynebacterium diphtheriae NCTC 13129 2650861 NP_938919.1 CDS DIP0543 NC_002935.2 512872 515037 D Similar to Micromonospora viridifaciens sialidase precursor NedA SW:NANH_MICVI (Q02834) (647 aa) fasta scores: E(): 4e-06, 33.62% id in 455 aa. Note: Contains a potential colied-coil region at residues 518..639; sialidase 512872..515037 Corynebacterium diphtheriae NCTC 13129 2650862 NP_938920.1 CDS DIP0544 NC_002935.2 515101 515910 D Similar to Streptomyces coelicolor secreted protein 3SC5B7.14c TR:Q9EWT5 (EMBL:AL449216) (231 aa) fasta scores: E(): 9.9e-08, 30.99% id in 242 aa; hypothetical protein 515101..515910 Corynebacterium diphtheriae NCTC 13129 2648832 NP_938921.1 CDS infA NC_002935.2 516214 516432 D stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 516214..516432 Corynebacterium diphtheriae NCTC 13129 2648833 NP_938922.1 CDS rpsM NC_002935.2 516618 516986 D located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 516618..516986 Corynebacterium diphtheriae NCTC 13129 2648834 NP_938923.1 CDS rpsK NC_002935.2 516990 517394 D located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 516990..517394 Corynebacterium diphtheriae NCTC 13129 2648835 NP_938924.1 CDS rpsD NC_002935.2 517418 518023 D primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 517418..518023 Corynebacterium diphtheriae NCTC 13129 2648836 NP_938925.1 CDS rpoA NC_002935.2 518105 519121 D catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 518105..519121 Corynebacterium diphtheriae NCTC 13129 2648837 NP_938926.1 CDS rplQ NC_002935.2 519202 519675 D is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 519202..519675 Corynebacterium diphtheriae NCTC 13129 2648838 NP_938927.1 CDS truA NC_002935.2 519770 520657 D mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 519770..520657 Corynebacterium diphtheriae NCTC 13129 2648839 NP_938928.1 CDS DIP0552 NC_002935.2 520801 522099 D Low similarity to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT3556 TR:AAK47896 (EMBL:AE007159) (482 aa) fasta scores: E(): 8.1e-16, 29.36% id in 487 aa; hypothetical protein 520801..522099 Corynebacterium diphtheriae NCTC 13129 2648840 NP_938929.1 CDS DIP0553 NC_002935.2 522208 522630 D Low similarity to Streptomyces coelicolor membrane protein SCl2.30c TR:Q9L269 (EMBL:AL137778) (150 aa) fasta scores: E(): 1.9e-06, 35.48% id in 93 aa; hypothetical protein 522208..522630 Corynebacterium diphtheriae NCTC 13129 2648841 NP_938930.1 CDS DIP0554 NC_002935.2 522858 523757 R Similar to Streptomyces coelicolor serine protease SC3C3.08 TR:O86642 (EMBL:AL031231) (413 aa) fasta scores: E(): 4e-11, 32.37% id in 278 aa and to Mycobacterium tuberculosis hypothetical 46.0 kDa protein Rv3449 or MTCY13E12.02 or MT3555 SWALL:O06316 (EMBL:Z95390) (455 aa) fasta scores: E(): 4.7e-10, 38.11% id in 307 aa; subtilisin-like cell wall associated serine protease (mycosin) complement(522858..523757) Corynebacterium diphtheriae NCTC 13129 2648842 NP_938931.1 CDS DIP0555 NC_002935.2 523770 525185 R Very low similarity to Mycobacterium tuberculosis hypothetical protein Rv3448 or MTCY77.20 or MT3554 SWALL:O33354 (EMBL:Z95390) (467 aa) fasta scores: E(): 0.0016, 21.96% id in 478 aa. Note: Contains a sortase anchor site (LPNTG); surface-anchored membrane protein complement(523770..525185) Corynebacterium diphtheriae NCTC 13129 2648875 NP_938932.1 CDS DIP0556 NC_002935.2 525441 528980 D Similar to Mycobacterium tuberculosis CDC1551 FtsK/SpoIIIE family protein MT3553 TR:AAK47893 (EMBL:AE007159) (1200 aa) fasta scores: E(): 1.7e-97, 37.59% id in 1221 aa; FtsK/SpoIIIE family ATP-binding protein 525441..528980 Corynebacterium diphtheriae NCTC 13129 2648876 NP_938933.1 CDS DIP0557 NC_002935.2 529045 530034 D hypothetical protein 529045..530034 Corynebacterium diphtheriae NCTC 13129 2648877 NP_938934.1 CDS DIP0558 NC_002935.2 530237 530554 D Very low similarity to Mycobacterium tuberculosis hypothetical 13.5 kDa protein Rv3445c or MTCY77.17c TR:O06262 (EMBL:Z95389) (125 aa) fasta scores: E(): 0.0007, 31.52% id in 92 aa; CFP-10-like protein 530237..530554 Corynebacterium diphtheriae NCTC 13129 2648878 NP_938935.1 CDS DIP0559 NC_002935.2 530599 530886 D Similar to Mycobacterium tuberculosis hypothetical 11.1 kDa protein Rv3444c or MTCY77.16c TR:O06261 (EMBL:Z95389) (100 aa) fasta scores: E(): 1e-08, 35.48% id in 93 aa; ESAT-6-like protein 530599..530886 Corynebacterium diphtheriae NCTC 13129 2648879 NP_938936.1 CDS DIP0560 NC_002935.2 530900 531049 D Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 530900..531049 Corynebacterium diphtheriae NCTC 13129 2648880 NP_938937.1 CDS rplM NC_002935.2 531311 531754 D in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 531311..531754 Corynebacterium diphtheriae NCTC 13129 2648881 NP_938938.1 CDS rpsI NC_002935.2 531751 532284 D forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 531751..532284 Corynebacterium diphtheriae NCTC 13129 2648882 NP_938939.1 CDS glmM NC_002935.2 532453 533796 D catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 532453..533796 Corynebacterium diphtheriae NCTC 13129 2649509 NP_938940.1 CDS DIP0564 NC_002935.2 533901 534200 D hypothetical protein 533901..534200 Corynebacterium diphtheriae NCTC 13129 2649510 NP_938941.1 CDS DIP0565 NC_002935.2 534197 535513 D No significant database matches. High concentration of alanine, glycine and proline residues; hypothetical protein 534197..535513 Corynebacterium diphtheriae NCTC 13129 2649511 NP_938942.1 CDS DIP0566 NC_002935.2 535507 535767 D hypothetical protein 535507..535767 Corynebacterium diphtheriae NCTC 13129 2649512 NP_938943.1 CDS DIP0567 NC_002935.2 535786 536649 R Similar to Mycobacterium leprae hypothetical protein ML0370 TR:Q9CCV6 (EMBL:AL583918) (289 aa) fasta scores: E(): 6.4e-34, 42.46% id in 252 aa; hypothetical protein complement(535786..536649) Corynebacterium diphtheriae NCTC 13129 2649513 NP_938944.1 CDS alr NC_002935.2 536812 537960 D converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 536812..537960 Corynebacterium diphtheriae NCTC 13129 2649514 NP_938945.1 CDS DIP0569 NC_002935.2 537967 538461 D Similar to Mycobacterium tuberculosis hypothetical 18.2 kDa protein Rv3422c or MT3531 or MTCY78.07 SW:YY22_MYCTU (Q50706) (168 aa) fasta scores: E(): 4.4e-19, 46.71% id in 152 aa; hypothetical protein 537967..538461 Corynebacterium diphtheriae NCTC 13129 2648765 NP_938946.1 CDS DIP0570 NC_002935.2 538648 540333 D Similar to Escherichia coli O157:H7 transport protein ECS4625 TR:BAB38048 (EMBL:AP002566) (561 aa) fasta scores: E(): 3.1e-24, 29.47% id in 536 aa; hypothetical protein 538648..540333 Corynebacterium diphtheriae NCTC 13129 2648766 NP_938947.1 CDS DIP0571 NC_002935.2 540480 540953 D hypothetical protein 540480..540953 Corynebacterium diphtheriae NCTC 13129 2648767 NP_938948.1 CDS DIP0572 NC_002935.2 541021 541689 D Similar to Mycobacterium leprae hypothetical 38.0 kDa protein ML0378 precursor or B229_C1_170 SW:YY21_MYCLE (Q49857) (359 aa) fasta scores: E(): 4.2e-30, 48.16% id in 218 aa; hypothetical protein 541021..541689 Corynebacterium diphtheriae NCTC 13129 2648768 NP_938949.1 CDS DIP0573 NC_002935.2 541690 542181 D Similar to Escherichia coli ribosomal-protein-alanine acetyltransferase RimI or B4373 or Z5974 or ECS5331 SW:RIMI_ECOLI (P09453) (148 aa) fasta scores: E(): 4.9e-09, 34.4% id in 125 aa; ribosomal-protein-alanine acetyltransferase 541690..542181 Corynebacterium diphtheriae NCTC 13129 2648769 NP_938950.1 CDS DIP0574 NC_002935.2 542182 543234 D in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease 542182..543234 Corynebacterium diphtheriae NCTC 13129 2648770 NP_938951.1 CDS groES NC_002935.2 543376 543672 D 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 543376..543672 Corynebacterium diphtheriae NCTC 13129 2648771 NP_938952.1 CDS groEL NC_002935.2 543685 545304 D 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is not essential for growth; molecular chaperone GroEL 543685..545304 Corynebacterium diphtheriae NCTC 13129 2648772 NP_938953.1 CDS DIP0577 NC_002935.2 545504 546070 D Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this protein is involved in expression of ribosome-associated gene products in stationary phase; RNA polymerase sigma factor SigD 545504..546070 Corynebacterium diphtheriae NCTC 13129 2649651 NP_938954.1 CDS DIP0578 NC_002935.2 546067 546969 D hypothetical protein 546067..546969 Corynebacterium diphtheriae NCTC 13129 2649652 NP_938955.1 CDS DIP0579 NC_002935.2 547039 547425 R Similar to Mycobacterium tuberculosis hypothetical 15.3 kDa protein Rv3412 or MT3521 or MTCY78.16C SW:YY12_MYCTU (Q50714) (136 aa) fasta scores: E(): 7.8e-18, 43.36% id in 113 aa; hypothetical protein complement(547039..547425) Corynebacterium diphtheriae NCTC 13129 2649653 NP_938956.1 CDS guaB NC_002935.2 547582 549102 D catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 547582..549102 Corynebacterium diphtheriae NCTC 13129 2649654 NP_938957.1 CDS DIP0581 NC_002935.2 549130 550275 D catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5-monophosphate dehydrogenase 549130..550275 Corynebacterium diphtheriae NCTC 13129 2649655 NP_938958.1 CDS DIP0582 NC_002935.2 550408 551304 D Similar to Escherichia coli iron FecB or B4290 SW:FECB_ECOLI (P15028) (300 aa) fasta scores: E(): 1.6e-12, 28.57% id in 287 aa; iron transport system binding (secreted) protein 550408..551304 Corynebacterium diphtheriae NCTC 13129 2649656 NP_938959.1 CDS DIP0583 NC_002935.2 551335 552324 D Similar to Escherichia coli iron FecC or B4289 SW:FECC_ECOLI (P15030) (332 aa) fasta scores: E(): 1.6e-22, 33.77% id in 305 aa; iron transport system membrane protein 551335..552324 Corynebacterium diphtheriae NCTC 13129 2649657 NP_938960.1 CDS DIP0584 NC_002935.2 552324 553307 D Similar to Escherichia coli iron FecD or B4288 SW:FECD_ECOLI (P15029) (318 aa) fasta scores: E(): 2.6e-28, 35.01% id in 317 aa; iron transport system membrane protein 552324..553307 Corynebacterium diphtheriae NCTC 13129 2649658 NP_938961.1 CDS DIP0585 NC_002935.2 553311 554123 D Similar to Bacillus subtilis ferrichrome transport ATP-binding protein FhuC SW:FHUC_BACSU (P49938) (269 aa) fasta scores: E(): 1.2e-37, 45.13% id in 257 aa, and to Escherichia coli iron FecE or B4287 SW:FECE_ECOLI (P15031) (255 aa) fasta scores: E(): 5e-32, 42.8% id in 250 aa; iron ABC transporter ATP-binding protein 553311..554123 Corynebacterium diphtheriae NCTC 13129 2650252 NP_938962.1 CDS DIP0586 NC_002935.2 554145 557468 D Similar in its N-terminal region and C-terminal region to Rhizobium sp hypothetical 71.0 kDa protein Y4xN SW:Y4XN_RHISN (P55706) blast scores: E(): 3e-23, score: 277 22% id and also to Rhizobium meliloti rhizobactin siderophore biosynthesis protein RhbC or RhsC or RA1260 or SMA2404 SWALL:AAK65918 (EMBL:AF110737) (585 aa) fasta scores: E(): 6e-12, 26.23% id in 526 aa. Possible duplication; siderophore biosynthesis-like protein 554145..557468 Corynebacterium diphtheriae NCTC 13129 2650253 NP_938963.1 CDS DIP0587 NC_002935.2 557508 558737 D Similar to Streptomyces coelicolor membrane transport protein SC5F8.19 TR:Q9K4K5 (EMBL:AL357613) (444 aa) fasta scores: E(): 7.2e-10, 27.72% id in 404 aa; hypothetical protein 557508..558737 Corynebacterium diphtheriae NCTC 13129 2650254 NP_938964.1 CDS DIP0588 NC_002935.2 558764 559198 D hypothetical protein 558764..559198 Corynebacterium diphtheriae NCTC 13129 2650255 NP_938965.1 CDS DIP0589 NC_002935.2 559337 560233 R Similar to Streptomyces coelicolor integral membrane protein SCD10.06 TR:Q9K3X0 (EMBL:AL359988) (295 aa) fasta scores: E(): 6.6e-36, 43.82% id in 267 aa; hypothetical protein complement(559337..560233) Corynebacterium diphtheriae NCTC 13129 2650256 NP_938966.1 CDS DIP0592 NC_002935.2 560966 561250 D hypothetical protein 560966..561250 Corynebacterium diphtheriae NCTC 13129 2649110 NP_938967.1 CDS DIP0593 NC_002935.2 561256 561825 D hypothetical protein 561256..561825 Corynebacterium diphtheriae NCTC 13129 2649111 NP_938968.1 CDS DIP0594 NC_002935.2 562125 562346 D hypothetical protein 562125..562346 Corynebacterium diphtheriae NCTC 13129 2649112 NP_938969.1 CDS guaA NC_002935.2 562428 564005 D contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 562428..564005 Corynebacterium diphtheriae NCTC 13129 2649349 NP_938970.1 CDS DIP0596 NC_002935.2 564081 564779 R hypothetical protein complement(564081..564779) Corynebacterium diphtheriae NCTC 13129 2649113 NP_938971.1 CDS DIP0597 NC_002935.2 564837 565313 D hypothetical protein 564837..565313 Corynebacterium diphtheriae NCTC 13129 2649114 NP_938972.1 CDS DIP0598 NC_002935.2 565332 566465 R hypothetical protein complement(565332..566465) Corynebacterium diphtheriae NCTC 13129 2649115 NP_938973.1 CDS DIP0599 NC_002935.2 566547 567758 D Similar to Streptomyces coelicolor two-component system sensor kinase SCD63A.02 TR:Q9KY73 (EMBL:AL356832) (430 aa) fasta scores: E(): 3e-12, 37.09% id in 434 aa; two component system sensor kinase 566547..567758 Corynebacterium diphtheriae NCTC 13129 2649116 NP_938974.1 CDS DIP0600 NC_002935.2 567764 568459 D Similar to Streptomyces coelicolor two-component system DNA-binding response regulator SSCD63A.03 TR:Q9KY72 (EMBL:AL356832) (251 aa) fasta scores: E(): 3.8e-26, 58.72% id in 235 aa, and to Bacillus brevis transcriptional regulatory protein DegU SW:DEGU_BACBR (P54662) (236 aa) fasta scores: E(): 2.7e-10, 30.97% id in 226 aa; two component system response regulator 567764..568459 Corynebacterium diphtheriae NCTC 13129 2649117 NP_938975.1 CDS DIP0601 NC_002935.2 568608 568958 D hypothetical protein 568608..568958 Corynebacterium diphtheriae NCTC 13129 2649118 NP_938976.1 CDS DIP0602 NC_002935.2 569168 569617 R hypothetical protein complement(569168..569617) Corynebacterium diphtheriae NCTC 13129 2649119 NP_938977.1 CDS DIP0603 NC_002935.2 569646 570416 D hypothetical protein 569646..570416 Corynebacterium diphtheriae NCTC 13129 2649120 NP_938978.1 CDS DIP0604 NC_002935.2 570425 571951 D Similar to Mycobacterium tuberculosis hypothetical 56.7 kDa protein Rv3394c or MTV004.52c TR:O50419 (EMBL:AL009198) (527 aa) fasta scores: E(): 2e-34, 32.63% id in 527 aa; hypothetical protein 570425..571951 Corynebacterium diphtheriae NCTC 13129 2648522 NP_938979.1 CDS DIP0605 NC_002935.2 571955 572656 R hypothetical protein complement(571955..572656) Corynebacterium diphtheriae NCTC 13129 2648523 NP_938980.1 CDS DIP0606 NC_002935.2 572761 573639 D Similar to Corynebacterium glutamicum hypothetical 31.3 kDa protein TR:Q93QX1 (EMBL:AF159510) (287 aa) fasta scores: E(): 3.9e-56, 51.52% id in 295 aa; hypothetical protein 572761..573639 Corynebacterium diphtheriae NCTC 13129 2648524 NP_938981.1 CDS DIP0607 NC_002935.2 573656 575113 R Similar to Mycobacterium tuberculosis hypothetical 33.4 kDa protein Rv3104c or MTCY164.14c TR:O05781 (EMBL:Z95150) (308 aa) fasta scores: E(): 1.3e-15, 33.94% id in 271 aa; hypothetical protein complement(573656..575113) Corynebacterium diphtheriae NCTC 13129 2648525 NP_938982.1 CDS DIP0608 NC_002935.2 575214 575891 R Similar to Staphylococcus aureus (strain N315) SA0421 protein or SAV0463 TR:BAB56625 (EMBL:AP003130) (219 aa) fasta scores: E(): 1.7e-31, 46.6% id in 206 aa, and to Salmonella enteritidis integral membrane protein SfbC TR:Q9S4Y9 (EMBL:AF102556) (202 aa) fasta scores: E(): 8.9e-28, 42.71% id in 199 aa; ABC transporter complement(575214..575891) Corynebacterium diphtheriae NCTC 13129 2648526 NP_938983.1 CDS DIP0609 NC_002935.2 575888 576910 R Similar to Bacillus halodurans ABC transporter BH3481 TR:Q9K789 (EMBL:AP001518) (338 aa) fasta scores: E(): 1.1e-47, 48.61% id in 325 aa, and to N-terminal region of Escherichia coli ATP-binding protein ABC or B0199 SW:ABC_ECOLI (P30750) (343 aa) fasta scores: E(): 3.9e-43, 55.2% id in 250 aa; ABC transporter ATP-binding protein complement(575888..576910) Corynebacterium diphtheriae NCTC 13129 2648527 NP_938984.1 CDS DIP0610 NC_002935.2 576948 577820 R Similar to Escherichia coli lipoprotein-28 precursor NlpA or B3661 SW:NLPA_ECOLI (P04846) (272 aa) fasta scores: E(): 1.9e-20, 34.36% id in 259 aa. Possible duplication of the CDS upstream, CDIP0611 (66.667% identity in 288 aa overlap); ABC transporter complement(576948..577820) Corynebacterium diphtheriae NCTC 13129 2648528 NP_938985.1 CDS DIP0611 NC_002935.2 577994 578866 R Similar to Escherichia coli lipoprotein-28 precursor NlpA or B3661 SW:NLPA_ECOLI (P04846) (272 aa) fasta scores: E(): 1.5e-20, 33.83% id in 266 aa. Possible duplication of the CDS downstream, CDIP0610 (66.667% identity in 288 aa overlap); ABC transporter complement(577994..578866) Corynebacterium diphtheriae NCTC 13129 2648529 NP_938986.1 CDS dnaE2 NC_002935.2 579083 582202 D DNA polymerase involved in damage-induced mutagenesis and translesion synthesis. It is not the major replicative DNA polymerase.; error-prone DNA polymerase 579083..582202 Corynebacterium diphtheriae NCTC 13129 2648530 NP_938987.1 CDS DIP0613 NC_002935.2 582222 582692 D Similar to Streptomyces coelicolor integral membrane protein SCE126.11 TR:Q9X854 (EMBL:AL049630) (151 aa) fasta scores: E(): 1.4e-15, 41.21% id in 148 aa; hypothetical protein 582222..582692 Corynebacterium diphtheriae NCTC 13129 2648531 NP_938988.1 CDS DIP0614 NC_002935.2 582689 584029 D Similar to Streptomyces coelicolor hypothetical 47.7 kDa protein SCE9.01 TR:Q9X8H4 (EMBL:AL049841) (436 aa) fasta scores: E(): 8.3e-18, 28.97% id in 428 aa; hypothetical protein 582689..584029 Corynebacterium diphtheriae NCTC 13129 2648532 NP_938989.1 CDS DIP0615 NC_002935.2 584097 585062 D Similar to Yersinia pestis periplasmic chelated iron-binding protein YfeA precursor or YPO2439 SW:YFEA_YERPE (Q56952) (311 aa) fasta scores: E(): 1.8e-19, 30.03% id in 303 aa; ABC transporter 584097..585062 Corynebacterium diphtheriae NCTC 13129 2648533 NP_938990.1 CDS DIP0616 NC_002935.2 585131 585916 D Similar to Yersinia pestis chelated iron transport system membrane protein YfeB or YPO2440 SW:YFEB_YERPE (Q56953) (296 aa) fasta scores: E(): 1.7e-20, 37.05% id in 251 aa; ABC transporter ATP-binding protein 585131..585916 Corynebacterium diphtheriae NCTC 13129 2650466 NP_938991.1 CDS DIP0617 NC_002935.2 585906 586739 D Similar to Yersinia pestis chelated iron transport system membrane protein YfeC or YPO2441 SW:YFEC_YERPE (Q56954) (294 aa) fasta scores: E(): 1.6e-13, 26.81% id in 276 aa; ABC transporter 585906..586739 Corynebacterium diphtheriae NCTC 13129 2650467 NP_938992.1 CDS DIP0618 NC_002935.2 586736 587542 D Similar to Lactococcus lactis manganese ABC transporter permease MtsC TR:Q9CFZ4 (EMBL:AE006363) (281 aa) fasta scores: E(): 3.3e-13, 27.96% id in 261 aa; ABC transporter 586736..587542 Corynebacterium diphtheriae NCTC 13129 2650468 NP_938993.1 CDS DIP0619 NC_002935.2 587557 588171 D Similar to Mycobacterium tuberculosis iron-dependent repressor IdeR or DtxR or Rv2711 or MT2784 or MTCY05A6.32 SW:IDER_MYCTU (Q50495) (230 aa) fasta scores: E(): 1.1e-10, 31.84% id in 201 aa and low similarity to Corynebacterium diphtheriae diphtheria toxin repressor DtxR SW:DTXR_CORDI (P33120) (226 aa) fasta scores: E(): 7.7e-08, 35.08% identity in 114 aa overlap; diphtheria toxin repressor 2 587557..588171 Corynebacterium diphtheriae NCTC 13129 2650469 NP_938994.1 CDS folD NC_002935.2 588393 589238 D catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 588393..589238 Corynebacterium diphtheriae NCTC 13129 2650470 NP_938995.1 CDS DIP0621 NC_002935.2 589231 589557 D hypothetical protein 589231..589557 Corynebacterium diphtheriae NCTC 13129 2650471 NP_938996.1 CDS DIP0622 NC_002935.2 589692 590957 R hypothetical protein complement(589692..590957) Corynebacterium diphtheriae NCTC 13129 2649046 NP_938997.1 CDS metX NC_002935.2 591014 592117 R Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine; homoserine O-acetyltransferase complement(591014..592117) Corynebacterium diphtheriae NCTC 13129 2649047 NP_938998.1 CDS DIP0624 NC_002935.2 592180 592731 R hypothetical protein complement(592180..592731) Corynebacterium diphtheriae NCTC 13129 2649048 NP_938999.1 CDS DIP0625 NC_002935.2 592944 594719 D Similar to the C-terminal region of Corynebacterium ulcerans HtaA TR:Q9EZ58 (EMBL:AF304009) (410 aa) fasta scores: E(): 4.9e-58, 54.14% id in 410 aa, and to Streptomyces coelicolor hypothetical 48.2 kDa protein SCC75A.17c TR:Q9RKQ7 (EMBL:AL133220) (477 aa) fasta scores: E(): 4.9e-06, 26.25% id in 579 aa; hypothetical protein 592944..594719 Corynebacterium diphtheriae NCTC 13129 2649049 NP_939000.1 CDS hmuT NC_002935.2 594730 595791 D Identical to previously sequenced Corynebacterium diphtheriae HmuT precursor TR:Q9XD89 (EMBL:AF109162) (353 aa) fasta scores: E(): 3.9e-123, 98.86% id in 353 aa, and highly similar to Corynebacterium ulcerans hemin receptor precursor HmuT TR:Q9EZ57 (EMBL:AF304009) (351 aa) fasta scores: E(): 2.6e-99, 79.83% id in 352 aa; Iron-related transport system receptor protein 594730..595791 Corynebacterium diphtheriae NCTC 13129 2649050 NP_939001.1 CDS hmuU NC_002935.2 595775 596827 D Almost identical to previously sequenced Corynebacterium diphtheriae HmuU TR:Q9XD88 (EMBL:AF109162) (350 aa) fasta scores: E(): 6.1e-120, 98% id in 350 aa, and highly similar to Corynebacterium ulcerans permease HmuU TR:Q9EZ56 (EMBL:AF304009) (350 aa) fasta scores: E(): 4.3e-100, 81.14% id in 350 aa; Iron-related transport system membrane protein 595775..596827 Corynebacterium diphtheriae NCTC 13129 2649051 NP_939002.1 CDS hmuV NC_002935.2 596848 597681 D Almost identical to the previously sequenced Corynebacterium diphtheriae HmuV TR:Q9XD87 (EMBL:AF109162) (277 aa) fasta scores: E(): 3.2e-88, 97.83% id in 277 aa, and to Escherichia coli iron (III) dicitrate transport ATP-binding protein FecE or B4287 SW:FECE_ECOLI (P15031) (255 aa) fasta scores: E(): 1.2e-23, 41.94% id in 236 aa; Iron-related transport system ATP-binding protein 596848..597681 Corynebacterium diphtheriae NCTC 13129 2649052 NP_939003.1 CDS DIP0629 NC_002935.2 597871 598848 D Almost identical to previously sequenced Corynebacterium diphtheriae secreted protein precursor TR:Q9XD85 (EMBL:AF109162) (339 aa) fasta scores: E(): 2.9e-99, 89.21% id in 306 aa; hypothetical protein 597871..598848 Corynebacterium diphtheriae NCTC 13129 2649053 NP_939004.1 CDS DIP0630 NC_002935.2 598958 600274 R catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol; O-acetylhomoserine aminocarboxypropyltransferase complement(598958..600274) Corynebacterium diphtheriae NCTC 13129 2649054 NP_939005.1 CDS icd NC_002935.2 600526 602739 R Highly similar to Corynebacterium glutamicum isocitrate dehydrogenase [NADP] Icd SW:IDH_CORGL (P50216) (738 aa) fasta scores: E(): 0, 83.31% id in 737 aa; isocitrate dehydrogenase complement(600526..602739) Corynebacterium diphtheriae NCTC 13129 2649055 NP_939006.1 CDS DIP0632 NC_002935.2 602928 604208 D Similar to Rhizobium meliloti transport transmembrane protein SMC02161 TR:CAC41922 (EMBL:AL591783) (411 aa) fasta scores: E(): 5.7e-56, 46.61% id in 384 aa, and to Streptomyces coelicolor transmembrane efflux protein SC1G2.16c TR:Q9RDR3 (EMBL:AL136500) (413 aa) fasta scores: E(): 4.7e-46, 41.62% id in 370 aa; hypothetical protein 602928..604208 Corynebacterium diphtheriae NCTC 13129 2649056 NP_939007.1 CDS DIP0633 NC_002935.2 604219 605124 D Similar to Streptomyces coelicolor exodeoxyribonuclease SCE87.25c TR:Q9RKB3 (EMBL:AL132674) (274 aa) fasta scores: E(): 2.6e-27, 44.3% id in 307 aa; exodeoxyribonuclease 604219..605124 Corynebacterium diphtheriae NCTC 13129 2649057 NP_939008.1 CDS DIP0634 NC_002935.2 605270 605449 D hypothetical protein 605270..605449 Corynebacterium diphtheriae NCTC 13129 2649945 NP_939009.1 CDS trpS NC_002935.2 605642 606676 D catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 605642..606676 Corynebacterium diphtheriae NCTC 13129 2649946 NP_939010.1 CDS DIP0636 NC_002935.2 606805 607965 D Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT3439 TR:AAK47783 (EMBL:AE007151) (289 aa) fasta scores: E(): 1.6e-33, 33.91% id in 286 aa; hypothetical protein 606805..607965 Corynebacterium diphtheriae NCTC 13129 2649947 NP_939011.1 CDS DIP0637 NC_002935.2 608070 609302 R Similar to Mycobacterium leprae D-alanyl-D-alanine carboxypeptidase ML0691 TR:Q9CCM2 (EMBL:AL583919) (411 aa) fasta scores: E(): 6.2e-45, 40.1% id in 389 aa, and to Bacillus subtilis penicillin-binding protein 5* precursor DacB SW:DACB_BACSU (P35150) (382 aa) fasta scores: E(): 2e-13, 30.26% id in 261 aa; peptidoglycan synthesis-like protein complement(608070..609302) Corynebacterium diphtheriae NCTC 13129 2649948 NP_939012.1 CDS DIP0638 NC_002935.2 609337 610281 D Low similarity to C-terminal region of Streptomyces coelicolor adenosine deaminase SC5H1.24c TR:Q9X7T2 (EMBL:AL049863) (359 aa) fasta scores: E(): 2.1e-06, 28.88% id in 225 aa; hypothetical protein 609337..610281 Corynebacterium diphtheriae NCTC 13129 2649949 NP_939013.1 CDS DIP0639 NC_002935.2 610555 611787 R Similar to Mycobacterium tuberculosis hypothetical 45.7 kDa protein Rv3311 or MTV016.10 TR:O53362 (EMBL:AL021841) (420 aa) fasta scores: E(): 1.4e-25, 34.05% id in 417 aa; hypothetical protein complement(610555..611787) Corynebacterium diphtheriae NCTC 13129 2649950 NP_939014.1 CDS DIP0640 NC_002935.2 611808 612647 R C-terminal region similar to C-terminal region of Mycobacterium leprae secreted protein ML0885 or MLCB268.32c TR:O69580 (EMBL:AL022602) (374 aa) fasta scores: E(): 4.6e-12, 37.57% id in 173 aa; hypothetical protein complement(611808..612647) Corynebacterium diphtheriae NCTC 13129 2649951 NP_939015.1 CDS DIP0641 NC_002935.2 612644 612925 R hypothetical protein complement(612644..612925) Corynebacterium diphtheriae NCTC 13129 2649952 NP_939016.1 CDS upp NC_002935.2 612990 613625 D Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 612990..613625 Corynebacterium diphtheriae NCTC 13129 2649953 NP_939017.1 CDS DIP0643 NC_002935.2 613790 614371 D DNA-binding protein 613790..614371 Corynebacterium diphtheriae NCTC 13129 2649954 NP_939018.1 CDS DIP0644 NC_002935.2 614468 615658 D Similar to Mycobacterium tuberculosis CDC1551 hydrolase, Ama/HipO/HyuC family MT3404 TR:AAK47747 (EMBL:AE007149) (389 aa) fasta scores: E(): 4.5e-74, 49.74% id in 388 aa; hypothetical protein 614468..615658 Corynebacterium diphtheriae NCTC 13129 2649955 NP_939019.1 CDS lpdA NC_002935.2 615701 617173 D catalyzes the reduction of nonspecific electron acceptors such as 2,6-dimethyl-1,4-benzoquinone and 5-hydroxy-1,4-naphthaquinone; does not have lipoamide dehydrogenase activity; flavoprotein disulfide reductase 615701..617173 Corynebacterium diphtheriae NCTC 13129 2649956 NP_939020.1 CDS pyc NC_002935.2 617693 621118 D biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate; pyruvate carboxylase 617693..621118 Corynebacterium diphtheriae NCTC 13129 2649499 NP_939021.1 CDS DIP0647 NC_002935.2 621208 621972 R Similar to Streptococcus pyogenes hypothetical protein SPY1216 TR:Q99ZI6 (EMBL:AE006562) (270 aa) fasta scores: E(): 3.2e-07, 33.82% id in 136 aa; hypothetical protein complement(621208..621972) Corynebacterium diphtheriae NCTC 13129 2649500 NP_939022.1 CDS DIP0648 NC_002935.2 621987 622391 R hypothetical protein complement(621987..622391) Corynebacterium diphtheriae NCTC 13129 2649501 NP_939023.1 CDS accBC NC_002935.2 622563 624347 R Similar to Corynebacterium glutamicum acyl coenzyme A carboxylase AccBC TR:P71122 (EMBL:U35023) (591 aa) fasta scores: E(): 1.5e-188, 85.47% id in 592 aa, and to Mycobacterium leprae acetyl-/propionyl-coenzyme A carboxylase alpha chain [includes: biotin carboxylase ; biotin carboxyl carrier protein(BCCP)] BccA or ML0726 or B1308_C1_129 SW:BCCA_MYCLE (P46392) (598 aa) fasta scores: E(): 1.1e-159, 72.46% id in 592 aa; acyl coenzyme A carboxylase complement(622563..624347) Corynebacterium diphtheriae NCTC 13129 2649502 NP_939024.1 CDS sseA NC_002935.2 624604 625485 R Similar to Mycobacterium tuberculosis thiosulfate sulfurtransferase SseA or Rv3283 or MT3382 or MTCY71.23 SW:THT2_MYCTU (P96888) (297 aa) fasta scores: E(): 1.5e-78, 60.67% id in 295 aa, and to Corynebacterium glutamicum thiosulfate sulfurtransferase ThtR SW:THTR_CORGL (P71121) (225 aa) fasta scores: E(): 1.2e-56, 63.72% id in 215 aa; thiosulfate sulfurtransferase complement(624604..625485) Corynebacterium diphtheriae NCTC 13129 2649503 NP_939025.1 CDS DIP0651 NC_002935.2 626082 627140 D Similar to Campylobacter jejuni hypothetical protein CJ0069 TR:Q9PJ50 (EMBL:AL139074) (343 aa) fasta scores: E(): 3e-85, 61.36% id in 352 aa; hypothetical protein 626082..627140 Corynebacterium diphtheriae NCTC 13129 2650227 NP_939026.1 CDS DIP0652 NC_002935.2 627335 629452 D Similar to Mycobacterium leprae conserved membrane protein ML1213 TR:Q9CC68 (EMBL:AL583921) (733 aa) fasta scores: E(): 1.2e-78, 38.27% id in 708 aa; hypothetical protein 627335..629452 Corynebacterium diphtheriae NCTC 13129 2650228 NP_939027.1 CDS DIP0653 NC_002935.2 629449 629877 R Similar to Mycobacterium leprae hypothetical 14.5 kDa protein ML0284 or MLCB4.27c TR:O69598 (EMBL:AL023514) (137 aa) fasta scores: E(): 3.5e-22, 50% id in 140 aa; hypothetical protein complement(629449..629877) Corynebacterium diphtheriae NCTC 13129 2650229 NP_939028.1 CDS maf NC_002935.2 629879 630475 R Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein complement(629879..630475) Corynebacterium diphtheriae NCTC 13129 2650230 NP_939029.1 CDS DIP0655 NC_002935.2 630494 631399 R Similar to Streptomyces coelicolor carbohydrate kinase SCC57A.19 TR:Q9RDH9 (EMBL:AL136519) (306 aa) fasta scores: E(): 1.3e-32, 44.06% id in 295 aa, and to Escherichia coli ribokinase RbsK or B3752 or Z5253 or ECS4694 SW:RBSK_ECOLI (P05054) (309 aa) fasta scores: E(): 4.3e-24, 35.69% id in 297 aa; ribokinase complement(630494..631399) Corynebacterium diphtheriae NCTC 13129 2650231 NP_939030.1 CDS DIP0656 NC_002935.2 631544 632599 R Similar to Streptomyces coelicolor probable lacI-family transcriptional regulator SCC57A.16 TR:Q9RDI2 (EMBL:AL136519) (347 aa) fasta scores: E(): 5.5e-32, 34.04% id in 326 aa, and to Bacillus megaterium glucose-resistance amylase regulator CcpA SW:CCPA_BACME (P46828) (332 aa) fasta scores: E(): 5.1e-24, 29.17% id in 329 aa; transcriptional regulator complement(631544..632599) Corynebacterium diphtheriae NCTC 13129 2650232 NP_939031.1 CDS DIP0657 NC_002935.2 632991 633251 R hypothetical protein complement(632991..633251) Corynebacterium diphtheriae NCTC 13129 2650233 NP_939032.1 CDS pccB1 NC_002935.2 633347 634978 R Similar to Corynebacterium glutamicum DtsR2 protein TR:O87201 (EMBL:AB018531) (537 aa) fasta scores: E(): 2e-182, 87.87% id in 536 aa, and to Saccharopolyspora erythraea propionyl-CoA carboxylase beta chain PccB SW:PCCB_SACER (P53003) (546 aa) fasta scores: E(): 5.2e-137, 64.83% id in 546 aa. Possible duplication of DIP0660 (69.309% identity in 492 aa overlap); propionyl CoA carboxylase subunitbeta complement(633347..634978) Corynebacterium diphtheriae NCTC 13129 2650234 NP_939033.1 CDS DIP0659 NC_002935.2 635607 636701 D hypothetical protein 635607..636701 Corynebacterium diphtheriae NCTC 13129 2650235 NP_939034.1 CDS pccB2 NC_002935.2 636944 638575 R Similar to Corynebacterium glutamicum DtsR1 protein TR:O88155 (EMBL:AB018531) (543 aa) fasta scores: E(): 1.5e-173, 81.76% id in 543 aa, and to Saccharopolyspora erythraea propionyl-CoA carboxylase beta chain PccB SW:PCCB_SACER (P53003) (546 aa) fasta scores: E(): 2.7e-127, 59.89% id in 546 aa. Possible duplication of DIP0658 (69.309% identity in 492 aa overlap); propionyl-CoA carboxylase subunit beta complement(636944..638575) Corynebacterium diphtheriae NCTC 13129 2650236 NP_939035.1 CDS DIP0661 NC_002935.2 638727 639527 D catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 638727..639527 Corynebacterium diphtheriae NCTC 13129 2650237 NP_939036.1 CDS DIP0662 NC_002935.2 639528 639992 D hypothetical protein 639528..639992 Corynebacterium diphtheriae NCTC 13129 2650238 NP_939037.1 CDS purK NC_002935.2 640046 641251 D With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 640046..641251 Corynebacterium diphtheriae NCTC 13129 2650239 NP_939038.1 CDS purE NC_002935.2 641251 641751 D Catalyzes a step in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase catalytic subunit 641251..641751 Corynebacterium diphtheriae NCTC 13129 2650240 NP_939039.1 CDS DIP0665 NC_002935.2 641756 642217 D Similar to the C-terminal region of Lactococcus lactis hypothetical protein YebE TR:Q9CIF2 (EMBL:AE006277) (194 aa) fasta scores: E(): 2.7e-05, 36.76% id in 136 aa; hypothetical protein 641756..642217 Corynebacterium diphtheriae NCTC 13129 2650241 NP_939040.1 CDS hypD NC_002935.2 642209 643324 R Similar to Escherichia coli hydrogenase isoenzymes formation protein HypD or B2729 SW:HYPD_ECOLI (P24192) (373 aa) fasta scores: E(): 4.1e-77, 51.73% id in 375 aa, and to Nostoc punctiforme HypD-like protein TR:Q9EYH5 (EMBL:AF325724) (392 aa) fasta scores: E(): 8.7e-94, 58.74% id in 366 aa; hydrogenase isoenzyme formation protein complement(642209..643324) Corynebacterium diphtheriae NCTC 13129 2650863 NP_939041.1 CDS hypC NC_002935.2 643324 643581 R Similar to Rhodobacter capsulatus hydrogenase expression/formation protein HypC SW:HYPC_RHOCA (P40428) (96 aa) fasta scores: E(): 4.7e-09, 50% id in 82 aa, and to Escherichia coli hydrogenase-2 operon protein HybG or B2990 or Z4344 or ECS3875 SW:HYBG_ECOLI (P37185) (82 aa) fasta scores: E(): 8e-08, 44% id in 75 aa; hydrogenase expression/formation protein HypC complement(643324..643581) Corynebacterium diphtheriae NCTC 13129 2650864 NP_939042.1 CDS hypE NC_002935.2 643639 644709 D Similar to Rhodobacter capsulatus hydrogenase expression/formation protein HypE SW:HYPE_RHOCA (P26412) (340 aa) fasta scores: E(): 8e-46, 49.7% id in 336 aa, and to Escherichia coli hydrogenase isoenzymes formation protein HypE or B2730 SW:HYPE_ECOLI (P24193) (322 aa) fasta scores: E(): 5.7e-38, 43.03% id in 323 aa; hydrogenase expression/formation protein HypE 643639..644709 Corynebacterium diphtheriae NCTC 13129 2650865 NP_939043.1 CDS DIP0669 NC_002935.2 644718 646952 R Similar to Azotobacter chroococcum MCD 1 hydrogenase maturation protein HypF or HupY SW:HYPF_AZOCH (Q43950) (776 aa) fasta scores: E(): 2.5e-73, 37.62% id in 784 aa, and to Escherichia coli hydrogenase maturation protein HypF or HydA or B2712 SW:HYPF_ECOLI (P30131) (750 aa) fasta scores: E(): 1e-43, 38.82% id in 765 aa; hydrogenase maturation protein complement(644718..646952) Corynebacterium diphtheriae NCTC 13129 2648478 NP_939044.1 CDS DIP0670 NC_002935.2 646965 647303 D Similar to Nostoc punctiforme hydrogenase nickel incorporation protein HypA SW:HYPA_NOSPU (Q9EYH3) (113 aa) fasta scores: E(): 4.6e-06, 30.35% id in 112 aa, and to Rhodobacter capsulatus hydrogenase nickel incorporation protein HypA or HupL SW:HYPA_RHOCA (P26409) (113 aa) fasta scores: E(): 0.0006, 27.67% id in 112 aa; hydrogenase nickel incorporation protein 646965..647303 Corynebacterium diphtheriae NCTC 13129 2649632 NP_939045.1 CDS DIP0671 NC_002935.2 647316 648077 D Similar to Rhodobacter capsulatus hydrogenase nickel incorporation protein HypB or HupM SW:HYPB_RHOCA (P26410) (335 aa) fasta scores: E(): 1.3e-34, 45.78% id in 249 aa, and to Escherichia coli hydrogenase isoenzymes nickel incorporation protein HypB or B2727 SW:HYPB_ECOLI (P24190) (290 aa) fasta scores: E(): 7.4e-34, 44.58% id in 231 aa; hydrogenase nickel incorporation protein 647316..648077 Corynebacterium diphtheriae NCTC 13129 2649633 NP_939046.1 CDS DIP0672 NC_002935.2 648378 649634 D Similar to Azotobacter vinelandii uptake hydrogenase small subunit precursor HoxK SW:MBHS_AZOVI (P21950) (358 aa) fasta scores: E(): 4.6e-64, 45.75% id in 365 aa, and to Escherichia coli hydrogenase-1 small chain precursor HyaA or B0972 SW:MBHS_ECOLI (P19928) (372 aa) fasta scores: E(): 1.3e-58, 42.54% id in 369 aa; uptake hydrogenase small subunit 648378..649634 Corynebacterium diphtheriae NCTC 13129 2649634 NP_939047.1 CDS DIP0673 NC_002935.2 649640 651385 D Similar to Bradyrhizobium japonicum uptake hydrogenase large subunit HupB or HupL SW:MBHL_BRAJA (P12636) (596 aa) fasta scores: E(): 2.8e-98, 45% id in 591 aa, and to Escherichia coli hydrogenase-1 large chain HyaB or B0973 SW:MBHL_ECOLI (P19927) (597 aa) fasta scores: E(): 2.5e-91, 41.25% id in 589 aa; uptake hydrogenase large subunit 649640..651385 Corynebacterium diphtheriae NCTC 13129 2649635 NP_939048.1 CDS DIP0674 NC_002935.2 651382 652536 D Similar to Bradyrhizobium japonicum probable Ni/Fe-hydrogenase B-type cytochrome subunit HupC SW:CYBH_BRAJA (P21960) (244 aa) fasta scores: E(): 2.3e-16, 32.65% id in 245 aa, and to Escherichia coli probable Ni/Fe-hydrogenase 1 B-type cytochrome subunit HyaC or B0974 or Z1391 or ECS1130 SW:CYBH_ECOLI (P19929) (235 aa) fasta scores: E(): 6e-13, 30.04% id in 213 aa and N-terminal region similar to Homo sapiens vacuolar proton translocating ATPase 116 kDa subunit A isoform 2 SW:VPP2_HUMAN (Q9Y487) blast scores: E(): 2.6, score: 34 30% id; Ni/Fe-hydrogenase B-type cytochrome subunit 651382..652536 Corynebacterium diphtheriae NCTC 13129 2649636 NP_939049.1 CDS DIP0675 NC_002935.2 652547 653059 D Similar to Escherichia coli hydrogenase 2 maturation protease HybD or B2993 SW:HYBD_ECOLI (P37182) (164 aa) fasta scores: E(): 6.6e-12, 34.88% id in 172 aa; hydrogenase maturation protease 652547..653059 Corynebacterium diphtheriae NCTC 13129 2649637 NP_939050.1 CDS DIP0676 NC_002935.2 653056 653421 R Similar to Bradyrhizobium japonicum hydrogenase nickel incorporation protein HypA SW:HYPA_BRAJA (Q45256) (113 aa) fasta scores: E(): 4e-06, 28.07% id in 114 aa; hydrogenase nickel incorporation protein complement(653056..653421) Corynebacterium diphtheriae NCTC 13129 2649638 NP_939051.1 CDS DIP0677 NC_002935.2 653448 654491 D Similar to Methanococcus voltae methylviologen-reducing hydrogenase Vhu alpha subunit VhuA TR:Q00407 (EMBL:X61204) (420 aa) fasta scores: E(): 9e-06, 24.37% id in 398 aa; reducing hydrogenase subunit alpha 653448..654491 Corynebacterium diphtheriae NCTC 13129 2649639 NP_939052.1 CDS DIP0678 NC_002935.2 654497 654754 D Similar to Azotobacter vinelandii probable hydrogenase expression/formation protein HypC or HupF SW:HYPC_AZOVI (P31881) (84 aa) fasta scores: E(): 8.5e-06, 36.25% id in 80 aa, and to Escherichia coli hydrogenase-2 operon protein HybG or B2990 or Z4344 or ECS3875 SW:HYBG_ECOLI (P37185) (82 aa) fasta scores: E(): 0.0017, 28.94% id in 76 aa; hydrogenase operon protein 654497..654754 Corynebacterium diphtheriae NCTC 13129 2650259 NP_939053.1 CDS DIP0679 NC_002935.2 654751 655413 R Similar to Mycobacterium tuberculosis hypothetical 23.7 kDa protein Rv3268 or MTCY71.08 TR:P96873 (EMBL:Z92771) (229 aa) fasta scores: E(): 7.6e-11, 31.48% id in 235 aa; hypothetical protein complement(654751..655413) Corynebacterium diphtheriae NCTC 13129 2650260 NP_939054.1 CDS DIP0680 NC_002935.2 655425 656903 R Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT3367 TR:AAK47708 (EMBL:AE007146) (497 aa) fasta scores: E(): 6e-73, 50.1% id in 469 aa; hypothetical protein complement(655425..656903) Corynebacterium diphtheriae NCTC 13129 2650261 NP_939055.1 CDS DIP0681 NC_002935.2 657162 658052 D Similar to Mycobacterium tuberculosis CDC1551 glycosyl transferase MT3365 TR:AAK47706 (EMBL:AE007146) (301 aa) fasta scores: E(): 5.1e-56, 52.12% id in 282 aa; glycosyl transferase family protein 657162..658052 Corynebacterium diphtheriae NCTC 13129 2650262 NP_939056.1 CDS DIP0682 NC_002935.2 658206 659294 D Similar to Mycobacterium tuberculosis CDC1551 mannose-1-phosphate guanyltransferase MT3364 TR:AAK47705 (EMBL:AE007146) (359 aa) fasta scores: E(): 1e-93, 70.45% id in 352 aa; mannose-1-phosphate guanylyltransferase 658206..659294 Corynebacterium diphtheriae NCTC 13129 2650263 NP_939057.1 CDS DIP0683 NC_002935.2 659420 659557 D Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 659420..659557 Corynebacterium diphtheriae NCTC 13129 2650264 NP_939058.1 CDS DIP0684 NC_002935.2 659753 660052 D Highly similar on its C-terminal region to the C-terminal region of Streptomyces coelicolor regulatory protein WhiB TR:Q53963 (EMBL:X62287) (87 aa) fasta scores: E(): 2.4e-22, 82.6% id in 69 aa; regulatory protein 659753..660052 Corynebacterium diphtheriae NCTC 13129 2650265 NP_939059.1 CDS DIP0685 NC_002935.2 660126 660581 R Similar to Mycobacterium tuberculosis hypothetical 15.6 kDa protein Rv3259 or MTV015.04 TR:O53352 (EMBL:AL021840) (139 aa) fasta scores: E(): 4.2e-21, 50% id in 136 aa; hypothetical protein complement(660126..660581) Corynebacterium diphtheriae NCTC 13129 2650266 NP_939060.1 CDS DIP0686 NC_002935.2 660680 661093 D Similar to Mycobacterium tuberculosis CDC1551 hypothetical 16.8 kDa protein MT3356 TR:AAK47698 (EMBL:AE007146) (163 aa) fasta scores: E(): 8.5e-16, 47.65% id in 149 aa; hypothetical protein 660680..661093 Corynebacterium diphtheriae NCTC 13129 2650267 NP_939061.1 CDS manB NC_002935.2 661191 662567 D converts mannose-6-phosphate to mannose-1-phosphate; the resulting product is then converted to GDP-mannose by ManC which is then used in the synthesis of mannose-containing glycoconjugates that are important for mediating entry into host cells; phosphomannomutase 661191..662567 Corynebacterium diphtheriae NCTC 13129 2650268 NP_939062.1 CDS DIP0688 NC_002935.2 662616 663623 D Similar in its N-terminal region to Mycobacterium tuberculosis hypothetical 35.3 kDa protein Rv3256c or MTV015.01c or MTCY20b11.31c TR:O05899 (EMBL:Z95121) (346 aa) fasta scores: E(): 5.1e-06, 27.69% id in 260 aa; hypothetical protein 662616..663623 Corynebacterium diphtheriae NCTC 13129 2650269 NP_939063.1 CDS DIP0689 NC_002935.2 663663 664832 D Similar to Mycobacterium tuberculosis CDC1551 mannose-6-phosphate isomerase MT3353 TR:AAK47695 (EMBL:AE007145) (408 aa) fasta scores: E(): 1.6e-57, 47.43% id in 409 aa, and to Escherichia coli mannose-6-phosphate isomerase ManA or Pmi or B1613 SW:MANA_ECOLI (P00946) (391 aa) fasta scores: E(): 1.7e-24, 38.34% id in 399 aa; mannose-phosphate isomerase 663663..664832 Corynebacterium diphtheriae NCTC 13129 2650270 NP_939064.1 CDS DIP0690 NC_002935.2 664858 665709 R No significant database matches. Contains various regions with high content in proline amino acid residues; hypothetical protein complement(664858..665709) Corynebacterium diphtheriae NCTC 13129 2650086 NP_939065.1 CDS DIP0691 NC_002935.2 666050 666403 D hypothetical protein 666050..666403 Corynebacterium diphtheriae NCTC 13129 2650625 NP_939066.1 CDS ahcY NC_002935.2 666509 667945 D catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine; S-adenosyl-L-homocysteine hydrolase 666509..667945 Corynebacterium diphtheriae NCTC 13129 2650626 NP_939067.1 CDS DIP0693 NC_002935.2 667945 668562 D catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 667945..668562 Corynebacterium diphtheriae NCTC 13129 2650627 NP_939068.1 CDS mtrA2 NC_002935.2 668619 669317 D Similar to Mycobacterium tuberculosis MtrA protein or Rv3246c or MTCY20B11.21c TR:Q50447 (EMBL:Z95121) (228 aa) fasta scores: E(): 7.6e-61, 70.66% id in 225 aa, and to Streptomyces coelicolor transcriptional regulatory protein AfsQ1 or 2SCK8.33c SW:AFQ1_STRCO (Q04942) (225 aa) fasta scores: E(): 2.4e-36, 45.2% id in 219 aa; two component system response regulator 668619..669317 Corynebacterium diphtheriae NCTC 13129 2649077 NP_939069.1 CDS mtrB NC_002935.2 669450 670892 D Similar to Mycobacterium tuberculosis MtrB or Rv3245c or MTCY20B11.20c TR:O05890 (EMBL:Z95121) (567 aa) fasta scores: E(): 4.6e-89, 53.73% id in 482 aa, and to Streptomyces coelicolor sensor protein AfsQ2 or 2SCK8.32c SW:AFQ2_STRCO (Q04943) (535 aa) fasta scores: E(): 1.4e-23, 30.64% id in 447 aa; two component system sensor kinase 669450..670892 Corynebacterium diphtheriae NCTC 13129 2649078 NP_939070.1 CDS DIP0696 NC_002935.2 670885 672630 D Similar to Mycobacterium tuberculosis hypothetical 61.2 kDa protein LpqB or Rv3244c or MTCY20B11.19c TR:O05889 (EMBL:Z95121) (583 aa) fasta scores: E(): 1.6e-14, 28.76% id in 591 aa; lipoprotein LpqB 670885..672630 Corynebacterium diphtheriae NCTC 13129 2649079 NP_939071.1 CDS DIP0697 NC_002935.2 672652 673254 D Similar to Mycobacterium tuberculosis hypothetical 22.5 kDa protein Rv3242c or MTCY20B11.17c TR:O05887 (EMBL:Z95121) (213 aa) fasta scores: E(): 8.3e-21, 41.5% id in 212 aa; hypothetical protein 672652..673254 Corynebacterium diphtheriae NCTC 13129 2649080 NP_939072.1 CDS DIP0698 NC_002935.2 673384 674052 D Similar to Mycobacterium leprae hypothetical protein ML0778 TR:Q9CCI7 (EMBL:AL583919) (229 aa) fasta scores: E(): 4.6e-35, 48.41% id in 221 aa; hypothetical protein 673384..674052 Corynebacterium diphtheriae NCTC 13129 2649081 NP_939073.1 CDS secA NC_002935.2 674230 676791 D functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 674230..676791 Corynebacterium diphtheriae NCTC 13129 2649082 NP_939074.1 CDS DIP0700 NC_002935.2 676843 677046 D hypothetical protein 676843..677046 Corynebacterium diphtheriae NCTC 13129 2649083 NP_939075.1 CDS DIP0701 NC_002935.2 677455 677865 D Similar to C-terminal region of Mycobacterium tuberculosis CDC1551 hydrolase, haloacid dehalogenase-like family MT3486 TR:AAK47822 (EMBL:AE007155) (217 aa) fasta scores: E(): 0.0053, 32.35% id in 136 aa; hypothetical protein 677455..677865 Corynebacterium diphtheriae NCTC 13129 2649084 NP_939076.1 CDS DIP0702 NC_002935.2 677877 678383 D Similar to Mycobacterium tuberculosis hypothetical 17.8 kDa protein Rv3231c or MTCY20B11.06c TR:O05876 (EMBL:Z95121) (169 aa) fasta scores: E(): 2.4e-25, 53.52% id in 170 aa; hypothetical protein 677877..678383 Corynebacterium diphtheriae NCTC 13129 2649085 NP_939077.1 CDS DIP0703 NC_002935.2 678605 679675 D Similar to Mycobacterium tuberculosis hypothetical 40.8 kDa protein Rv3230c or MTCY20B11.05c TR:O05875 (EMBL:Z95121) (380 aa) fasta scores: E(): 4.8e-60, 49.14% id in 350 aa, and to Escherichia coli NADH oxidoreductase Hcr or B0872 SW:HCR_ECOLI (P75824) (322 aa) fasta scores: E(): 1.9e-13, 28.71% id in 296 aa; oxidoreductase 678605..679675 Corynebacterium diphtheriae NCTC 13129 2649086 NP_939078.1 CDS DIP0704 NC_002935.2 679690 680970 D Similar to Mycobacterium tuberculosis hypothetical 48.4 kDa protein DesA3 or Rv3229c or MTCY20B11.04c TR:O05874 (EMBL:Z95121) (427 aa) fasta scores: E(): 1.5e-86, 52.59% id in 405 aa; hypothetical protein 679690..680970 Corynebacterium diphtheriae NCTC 13129 2649087 NP_939079.1 CDS DIP0705 NC_002935.2 680972 681979 R Similar to Mycobacterium tuberculosis hypothetical 34.9 kDa protein Rv3228 or MTCY20B11.03 TR:O05873 (EMBL:Z95121) (330 aa) fasta scores: E(): 9.1e-70, 60.18% id in 324 aa; hypothetical protein complement(680972..681979) Corynebacterium diphtheriae NCTC 13129 2649088 NP_939080.1 CDS aroA NC_002935.2 681984 683279 R catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase complement(681984..683279) Corynebacterium diphtheriae NCTC 13129 2649089 NP_939081.1 CDS DIP0707 NC_002935.2 683297 683959 D Similar to Halobacterium sp VNG0686c TR:Q9HRI0 (EMBL:AE005014) (229 aa) fasta scores: E(): 4.5e-12, 35.51% id in 245 aa; hypothetical protein 683297..683959 Corynebacterium diphtheriae NCTC 13129 2650208 NP_939082.1 CDS DIP0708 NC_002935.2 683945 684448 R Similar to Escherichia coli protein YbaK or B0481 SW:YBAK_ECOLI (P37175) (159 aa) fasta scores: E(): 1.2e-21, 46.49% id in 157 aa; hypothetical protein complement(683945..684448) Corynebacterium diphtheriae NCTC 13129 2650209 NP_939083.1 CDS rpoE NC_002935.2 684494 685117 D Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE 684494..685117 Corynebacterium diphtheriae NCTC 13129 2650210 NP_939084.1 CDS DIP0710 NC_002935.2 685114 685365 D Similar to Streptomyces coelicolor anti-sigma factor RsrA TR:Q9RL96 (EMBL:AJ010320) (105 aa) fasta scores: E(): 5.5e-06, 35.71% id in 70 aa; anti sigma factor 685114..685365 Corynebacterium diphtheriae NCTC 13129 2650211 NP_939085.1 CDS DIP0711 NC_002935.2 685370 685714 R hypothetical protein complement(685370..685714) Corynebacterium diphtheriae NCTC 13129 2650212 NP_939086.1 CDS DIP0712 NC_002935.2 686052 686312 R Similar to Mycobacterium leprae transcriptional regulator WhiB1 or ML0804 TR:Q9CCH7 (EMBL:AL583919) (84 aa) fasta scores: E(): 1.5e-29, 81.7% id in 82 aa; transcriptional regulator complement(686052..686312) Corynebacterium diphtheriae NCTC 13129 2650213 NP_939087.1 CDS DIP0713 NC_002935.2 686383 686781 D hypothetical protein 686383..686781 Corynebacterium diphtheriae NCTC 13129 2650214 NP_939088.1 CDS DIP0715 NC_002935.2 686945 687406 D Similar to Mycobacterium leprae membrane protein ML0806 TR:Q9CCH6 (EMBL:AL583919) (173 aa) fasta scores: E(): 2e-07, 38.34% id in 133 aa; hypothetical protein 686945..687406 Corynebacterium diphtheriae NCTC 13129 2650215 NP_939089.1 CDS DIP0716 NC_002935.2 687400 688662 R Low similarity to Mycobacterium leprae membrane protein ML0810 TR:Q9CCH4 (EMBL:AL583919) (407 aa) fasta scores: E(): 1.1e-21, 26.81% id in 414 aa; hypothetical protein complement(687400..688662) Corynebacterium diphtheriae NCTC 13129 2650216 NP_939090.1 CDS DIP0717 NC_002935.2 688659 689969 R Similar to Mycobacterium leprae ATP-dependent RNA helicase RhlE or ML0811 TR:Q9CCH3 (EMBL:AL583919) (544 aa) fasta scores: E(): 2.1e-87, 55.78% id in 441 aa, and to Klebsiella pneumoniae cold-shock dead-box protein A DeaD or CsdA SW:DEAD_KLEPN (P33906) (642 aa) fasta scores: E(): 5.7e-49, 41.91% id in 377 aa; ATP-dependent RNA helicase complement(688659..689969) Corynebacterium diphtheriae NCTC 13129 2650217 NP_939091.1 CDS DIP0718 NC_002935.2 690051 690176 R Doubtful CDS. No significant database matches; hypothetical protein complement(690051..690176) Corynebacterium diphtheriae NCTC 13129 2650218 NP_939092.1 CDS DIP0719 NC_002935.2 690227 690454 D Similar to Mycobacterium tuberculosis CDC1551 hypothetical 10.1 kDa protein MT3304 TR:AAK47646 (EMBL:AE007142) (97 aa) fasta scores: E(): 4.5e-11, 51.38% id in 72 aa; hypothetical protein 690227..690454 Corynebacterium diphtheriae NCTC 13129 2650219 NP_939093.1 CDS DIP0720 NC_002935.2 690457 691335 D Similar to Mycobacterium tuberculosis hypothetical 31.0 kDa protein Rv3207c or MTCY07D11.19 TR:O05859 (EMBL:Z95120) (285 aa) fasta scores: E(): 1.7e-44, 46.69% id in 287 aa; hypothetical protein 690457..691335 Corynebacterium diphtheriae NCTC 13129 2650220 NP_939094.1 CDS DIP0721 NC_002935.2 691359 692216 D Similar to Mycobacterium leprae hypothetical protein ML0818 TR:Q9CCG7 (EMBL:AL583919) (297 aa) fasta scores: E(): 1.2e-34, 39.47% id in 266 aa; hypothetical protein 691359..692216 Corynebacterium diphtheriae NCTC 13129 2650221 NP_939095.1 CDS DIP0722 NC_002935.2 692220 695402 D Similar to Streptomyces coelicolor ATP-dependent DNA helicase 2SC3B6.07 TR:Q9FCK5 (EMBL:AL390968) (1159 aa) fasta scores: E(): 6.2e-29, 32.21% id in 1161 aa; ATP-dependent DNA helicase 692220..695402 Corynebacterium diphtheriae NCTC 13129 2650222 NP_939096.1 CDS DIP0723 NC_002935.2 695396 698626 D Similar to Mycobacterium tuberculosis CDC1551 helicase, UvrD/Rep family MT3295 TR:AAK47638 (EMBL:AE007142) (1101 aa) fasta scores: E(): 2.9e-25, 43.03% id in 1120 aa; helicase 695396..698626 Corynebacterium diphtheriae NCTC 13129 2650223 NP_939097.1 CDS DIP0724 NC_002935.2 698671 699759 D Similar to Mycobacterium tuberculosis CDC1551 transporter, MT3294 TR:AAK47637 (EMBL:AE007142) (355 aa) fasta scores: E(): 2.5e-75, 61.78% id in 348 aa, and to Escherichia coli potassium channel protein Kch or B1250 SW:KCH_ECOLI (P31069) (417 aa) fasta scores: E(): 1.5e-07, 26.06% id in 234 aa; membrane transporter 698671..699759 Corynebacterium diphtheriae NCTC 13129 2650224 NP_939098.1 CDS DIP0725 NC_002935.2 699791 700474 D Similar to C-terminal region of Vibrio cholerae NADH pyrophosphatase NudC or VC0331 SW:NUDC_VIBCH (Q9KV27) (269 aa) fasta scores: E(): 2.3e-11, 32.75% id in 174 aa; hydrolase 699791..700474 Corynebacterium diphtheriae NCTC 13129 2650225 NP_939099.1 CDS uvrD NC_002935.2 700467 702518 D Similar to Mycobacterium tuberculosis probable DNA helicase II homolog UvrD or Rv3198c or MT3291 or MTV014.42c SW:UVRD_MYCTU (O53344) (700 aa) fasta scores: E(): 2.7e-133, 58.92% id in 689 aa, and to Escherichia coli DNA helicase II UvrD or MutU or PdeB or Rad or RecL or B3813 SW:UVRD_ECOLI (P03018) (720 aa) fasta scores: E(): 7.8e-37, 32.16% id in 656 aa; DNA helicase II 700467..702518 Corynebacterium diphtheriae NCTC 13129 2650226 NP_939100.1 CDS DIP0727 NC_002935.2 702463 703362 R Low similarity to Mycobacterium tuberculosis CDC1551 hypothetical 31.6 kDa protein MT3288 TR:AAK47629 (EMBL:AE007141) (299 aa) fasta scores: E(): 3.9e-06, 28.12% id in 288 aa; hypothetical protein complement(702463..703362) Corynebacterium diphtheriae NCTC 13129 2649309 NP_939101.1 CDS DIP0728 NC_002935.2 703392 703913 D Similar to Streptomyces coelicolor hypothetical 19.2 kDa protein 2SC3B6.18 TR:Q9FCJ4 (EMBL:AL390968) (168 aa) fasta scores: E(): 2e-25, 46% id in 150 aa; hypothetical protein 703392..703913 Corynebacterium diphtheriae NCTC 13129 2649310 NP_939102.1 CDS DIP0729 NC_002935.2 703910 705301 R Similar to Mycobacterium tuberculosis hypothetical 49.4 kDa protein Rv3195 or MTV014.39 TR:O53341 (EMBL:AL021646) (472 aa) fasta scores: E(): 5.1e-65, 45.37% id in 432 aa; hypothetical protein complement(703910..705301) Corynebacterium diphtheriae NCTC 13129 2649311 NP_939103.1 CDS DIP0730 NC_002935.2 705382 706434 D Similar to Mycobacterium leprae secreted protein ML0643 TR:Q9CCM7 (EMBL:AL583919) (340 aa) fasta scores: E(): 5.2e-46, 43.42% id in 350 aa; hypothetical protein 705382..706434 Corynebacterium diphtheriae NCTC 13129 2649312 NP_939104.1 CDS DIP0731 NC_002935.2 706446 707147 R hypothetical protein complement(706446..707147) Corynebacterium diphtheriae NCTC 13129 2649313 NP_939105.1 CDS DIP0732 NC_002935.2 707195 707698 R hypothetical protein complement(707195..707698) Corynebacterium diphtheriae NCTC 13129 2649314 NP_939106.1 CDS DIP0733 NC_002935.2 707871 710834 D Similar to Mycobacterium tuberculosis integral membrane protein Rv3193c or MTV014.37c TR:O53339 (EMBL:AL021646) (992 aa) fasta scores: E(): 1e-154, 46.03% id in 1008 aa; hypothetical protein 707871..710834 Corynebacterium diphtheriae NCTC 13129 2649315 NP_939107.1 CDS DIP0734 NC_002935.2 711318 711887 R hypothetical protein complement(711318..711887) Corynebacterium diphtheriae NCTC 13129 2649317 NP_939108.1 CDS DIP0735 NC_002935.2 711917 712231 R hypothetical protein complement(711917..712231) Corynebacterium diphtheriae NCTC 13129 2649318 NP_939109.1 CDS DIP0736 NC_002935.2 712417 713427 R C-terminal region similar to Drosophila erecta trypsin zeta precursor Try-ZetA SW:TRYZ_DROER (P54630) (281 aa) fasta scores: E(): 0.17, 26.03% id in 242 aa; protease complement(712417..713427) Corynebacterium diphtheriae NCTC 13129 2649319 NP_939110.1 CDS DIP0737 NC_002935.2 713430 714386 R hypothetical protein complement(713430..714386) Corynebacterium diphtheriae NCTC 13129 2649320 NP_939111.1 CDS DIP0738 NC_002935.2 714642 714809 D Doubtful CDS. No significant database matches; hypothetical protein 714642..714809 Corynebacterium diphtheriae NCTC 13129 2649321 NP_939112.1 CDS pycB NC_002935.2 715065 716546 D Converts oxaloacetate to phosphoenolpyruvate using ATP as an energy source; oxaloacetate decarboxylase 715065..716546 Corynebacterium diphtheriae NCTC 13129 2649322 NP_939113.1 CDS mmdA NC_002935.2 716559 718115 D Similar to Propionigenium modestum methylmalonyl-CoA decarboxylase, alpha-subunit MmdA TR:O54028 (EMBL:AJ002015) (512 aa) fasta scores: E(): 2.2e-105, 54.1% id in 512 aa, and to Bacillus subtilis propionyl-CoA carboxylase beta chain YqjD SW:PCCB_BACSU (P54541) (506 aa) fasta scores: E(): 9.2e-91, 50.1% id in 497 aa; methylcrotonoyl-CoA carboxylase subunit alpha 716559..718115 Corynebacterium diphtheriae NCTC 13129 2649323 NP_939114.1 CDS DIP0741 NC_002935.2 718129 718392 D hypothetical protein 718129..718392 Corynebacterium diphtheriae NCTC 13129 2649324 NP_939115.1 CDS DIP0742 NC_002935.2 718417 718785 D Similar to Propionibacterium freudenreichii shermanii biotin carboxyl carrier protein of methylmalonyl-CoA carboxyl- transferase SW:BCCP_PROFR (P02904) (123 aa) fasta scores: E(): 2.6e-15, 49.18% id in 122 aa; decarboxylase 718417..718785 Corynebacterium diphtheriae NCTC 13129 2650544 NP_939116.1 CDS DIP0743 NC_002935.2 718856 720079 D hypothetical protein 718856..720079 Corynebacterium diphtheriae NCTC 13129 2650545 NP_939117.1 CDS DIP0744 NC_002935.2 720098 720886 R Similar to Mycobacterium tuberculosis hypothetical 27.7 kDa protein Rv3137 or MTCY03A2.21c TR:P95189 (EMBL:Z83867) (260 aa) fasta scores: E(): 1.4e-65, 63.42% id in 257 aa; hypothetical protein complement(720098..720886) Corynebacterium diphtheriae NCTC 13129 2650546 NP_939118.1 CDS DIP0745 NC_002935.2 720943 721815 R Similar to Rhizobium loti myo-inositol-1-monophosphotase MLR4874 TR:Q98D39 (EMBL:AP003005) (264 aa) fasta scores: E(): 1.9e-18, 32.92% id in 243 aa, and to Streptomyces spectabilis myo-inositol-1-monophosphotase SpcA TR:Q9L630 (EMBL:AF244574) (265 aa) fasta scores: E(): 3.8e-14, 31.59% id in 269 aa; hypothetical protein complement(720943..721815) Corynebacterium diphtheriae NCTC 13129 2650547 NP_939119.1 CDS prfB NC_002935.2 721938 723047 D recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 721938..723047 Corynebacterium diphtheriae NCTC 13129 2650548 NP_939120.1 CDS DIP0747 NC_002935.2 723044 724642 R Similar to Neisseria gonorrhoeae efflux pump component MtrF TR:Q9RNX1 (EMBL:AF176821) (522 aa) fasta scores: E(): 2.4e-35, 40.03% id in 527 aa, and to Escherichia coli aminobenzoyl-glutamate transport protein AbgT or B1336 SW:ABGT_ECOLI (P46133) (510 aa) fasta scores: E(): 1.7e-28, 34.72% id in 527 aa; hypothetical protein complement(723044..724642) Corynebacterium diphtheriae NCTC 13129 2650549 NP_939121.1 CDS ftsE NC_002935.2 724821 725510 D Similar to Streptomyces coelicolor cell division ATP-binding protein FtsE TR:Q9L1S6 (EMBL:AL138851) (229 aa) fasta scores: E(): 2.6e-43, 61.06% id in 226 aa, and to Escherichia coli cell division ATP-binding protein FtsE or B3463 or Z4837 or ECS4312 SW:FTSE_ECOLI (P10115) (222 aa) fasta scores: E(): 5.9e-26, 43.36% id in 226 aa; cell division ATP-binding protein 724821..725510 Corynebacterium diphtheriae NCTC 13129 2650550 NP_939122.1 CDS DIP0749 NC_002935.2 725527 726429 D Similar to Mycobacterium leprae cell division protein FtsX homolog or ML0670 or MLCB1779.20c SW:FTSX_MYCLE (O32882) (297 aa) fasta scores: E(): 3.4e-41, 41.19% id in 301 aa, and to Escherichia coli cell division protein FtsX or FtsS or B3462 SW:FTSX_ECOLI (P10122) (352 aa) fasta scores: E(): 3.5e-06, 25% id in 240 aa; cell division protein 725527..726429 Corynebacterium diphtheriae NCTC 13129 2650551 NP_939123.1 CDS smpB NC_002935.2 726536 727027 D binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 726536..727027 Corynebacterium diphtheriae NCTC 13129 2650552 NP_939124.1 CDS DIP0751 NC_002935.2 727065 727256 D Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 727065..727256 Corynebacterium diphtheriae NCTC 13129 2650553 NP_939125.1 CDS DIP0752 NC_002935.2 727618 728997 D Similar to Escherichia coli possible transposase of IS1353 YahA TR:Q9WTH9 (EMBL:AP000342) (514 aa) fasta scores: E(): 2.6e-62, 41.595% id in 464 aa, and to Escherichia coli transposase InsK for insertion sequence element IS150 or B3558 SW:INSK_ECOLI (P19769) (283 aa) fasta scores: E(): 2.7e-35, 38.628% id in 277 aa; IS element transposase 727618..728997 Corynebacterium diphtheriae NCTC 13129 2649350 NP_939126.1 CDS DIP0753 NC_002935.2 729107 732040 D Similar to Staphylococcus aureus lantibiotic modifying enzyme TR:Q9S4D1 (EMBL:AF147744) (965 aa) fasta scores: E(): 5.3e-32, 21.471% id in 1006 aa, and to Lactococcus lactis Plasmid pMRC01 lacticin 481/lactococcin biosynthesis protein LcnDR2 TR:O87238 (EMBL:AE001272) (980 aa) fasta scores: E(): 2.6e-16, 21.221% id in 999 aa; lantibiotic modifying enzyme 729107..732040 Corynebacterium diphtheriae NCTC 13129 2649351 NP_939127.1 CDS DIP0754 NC_002935.2 732028 734160 D Similar to Staphylococcus aureus transporter TR:Q9S4D0 (EMBL:AF147744) (720 aa) fasta scores: E(): 2.4e-57, 29.986% id in 707 aa, and to Lactococcus lactis cytolysin B transport protein TR:O87239 (EMBL:AE001272) (708 aa) fasta scores: E(): 7.1e-55, 28.571% id in 714 aa; lantibiotic ABC transporter membrane protein 732028..734160 Corynebacterium diphtheriae NCTC 13129 2649352 NP_939128.1 CDS DIP0755 NC_002935.2 734160 735038 D Similar to Bacillus subtilis SpaF TR:Q45404 (EMBL:U09819) (247 aa) fasta scores: E(): 2.2e-22, 42.991% id in 214 aa, and to Corynebacterium jeikeium BlsD TR:AAK94047 (EMBL:AF401314) (301 aa) fasta scores: E(): 2.5e-22, 33.106% id in 293 aa; lantibiotic ABC transporter ATP-binding protein 734160..735038 Corynebacterium diphtheriae NCTC 13129 2649353 NP_939129.1 CDS DIP0756 NC_002935.2 735038 735835 D Similar to Streptomyces coelicolor ABC transporter integral membrane protein SCE8.16c TR:Q9Z4W1 (EMBL:AL035654) (264 aa) fasta scores: E(): 0.0032, 26.695% id in 236 aa, and to Corynebacterium jeikeium BlsC TR:AAK94048 (EMBL:AF401314) (247 aa) fasta scores: E(): 0.81, 21.116% id in 251 aa; lantibiotic ABC transporter membrane protein 735038..735835 Corynebacterium diphtheriae NCTC 13129 2649354 NP_939130.1 CDS DIP0757 NC_002935.2 736001 736267 R Similar to part of Yersinia enterocolitica IS1222-like transposase TR:Q9X9I1 (EMBL:AJ132945) (165 aa) fasta scores: E(): 5.3e-08, 40.625% id in 64 aa, and of Xanthomonas campestris insertion element IS476 hypothetical 39.2 kDa protein SW:YI61_XANCA (P25438) (346 aa) fasta scores: E(): 3.3e-06, 34.722% id in 72 aa. Also similar to the C-terminal region of DIP0760, transposase (pseudogene) (361 aa) fasta scores: E(): 9.6e-27, 80.000% identity in 70 aa overlap; IS element transposase (partial) complement(736001..736267) Corynebacterium diphtheriae NCTC 13129 2649355 NP_939131.1 CDS DIP0757A NC_002935.2 736323 >736553 R Similar to part of Salmonella typhimurium LT2 integrase core domain STM2764 TR:AAL21650 (EMBL:AE008826) (155 aa) fasta scores: E(): 0.94, 36.36% id in 44 aa; IS element transposase (partial) complement(736323..>736553) Corynebacterium diphtheriae NCTC 13129 2649356 NP_939132.1 CDS DIP0758 NC_002935.2 736810 737148 D Similar to part of Mycobacterium ulcerans probable transposase Tnp TR:Q9ZG97 (EMBL:AF082836) (444 aa) fasta scores: E(): 1.5e-08, 50% id in 82 aa; transposase (partial) 736810..737148 Corynebacterium diphtheriae NCTC 13129 2649357 NP_939133.1 CDS DIP0761 NC_002935.2 738682 739023 R Similar to Methanothermobacter thermautotrophicus hypothetical 11.0 kDa protein MTH1452 TR:O27501 (EMBL:AE000906) (99 aa) fasta scores: E(): 2.8e-10, 41.48% id in 94 aa; hypothetical protein complement(738682..739023) Corynebacterium diphtheriae NCTC 13129 2649359 NP_939134.1 CDS DIP0762 NC_002935.2 739057 739860 R Similar to Mycobacterium tuberculosis hypothetical 29.5 kDa protein Rv2622 or MTCY01A10.10c TR:O06190 (EMBL:Z95387) (273 aa) fasta scores: E(): 2.9e-44, 50.96% id in 259 aa; hypothetical protein complement(739057..739860) Corynebacterium diphtheriae NCTC 13129 2649360 NP_939135.1 CDS DIP0764 NC_002935.2 740277 741590 R Similar to Escherichia coli transposase InsI for insertion sequence element IS30B/C/D (InsI1 or B0256) and (InsI2 or B1404) and (InsI3 or B4284) SW:INSI_ECOLI (P37246) (383 aa) fasta scores: E(): 7.2e-19, 37.94% id in 390 aa; transposase complement(740277..741590) Corynebacterium diphtheriae NCTC 13129 2648648 NP_939136.1 CDS tnpA1 NC_002935.2 742372 742674 R Similar to Corynebacterium jeikeium transposase A TnpA TR:AAK51146 (EMBL:AY033500) (103 aa) fasta scores: E(): 8.1e-16, 56% id in 100 aa; transposase A complement(742372..742674) Corynebacterium diphtheriae NCTC 13129 2648649 NP_939137.1 CDS DIP0771 NC_002935.2 749836 750483 R hypothetical protein complement(749836..750483) Corynebacterium diphtheriae NCTC 13129 2648654 NP_939138.1 CDS DIP0772 NC_002935.2 750488 752152 R Similar to Mycobacterium tuberculosis CDC1551 ATP-dependent DNA helicase, MT0884 TR:AAK45125 (EMBL:AE006976) (542 aa) fasta scores: E(): 1.5e-161, 74.63% id in 544 aa; ATP-dependent DNA helicase complement(750488..752152) Corynebacterium diphtheriae NCTC 13129 2648655 NP_939139.1 CDS DIP0773 NC_002935.2 752198 754516 R Similar to Mycobacterium leprae possible DNA-binding protein ML2156 TR:Q9CBE1 (EMBL:AL583924) (753 aa) fasta scores: E(): 1.2e-60, 33.5% id in 758 aa; DNA-binding protein complement(752198..754516) Corynebacterium diphtheriae NCTC 13129 2648656 NP_939140.1 CDS DIP0774 NC_002935.2 754535 754771 D Similar to Mycobacterium leprae hypothetical protein ML2155 TR:Q9CBE2 (EMBL:AL583924) (74 aa) fasta scores: E(): 7.5e-08, 54.09% id in 61 aa; hypothetical protein 754535..754771 Corynebacterium diphtheriae NCTC 13129 2648657 NP_939141.1 CDS DIP0775 NC_002935.2 754956 755579 R Similar to Streptomyces coelicolor secreted protein SCE41.06c TR:Q9F2Q2 (EMBL:AL442120) (244 aa) fasta scores: E(): 5.7e-20, 56.3% id in 119 aa; hypothetical protein complement(754956..755579) Corynebacterium diphtheriae NCTC 13129 2648658 NP_939142.1 CDS cspB NC_002935.2 756260 756649 D Similar to Mycobacterium tuberculosis cold shock protein B CspB or Rv0871 or MTV043.64 TR:O53883 (EMBL:AL022004) (135 aa) fasta scores: E(): 8.9e-24, 52.23% id in 134 aa, and to Streptomyces coelicolor cold shock protein B CspB TR:Q9KXN2 (EMBL:AL357524) (127 aa) fasta scores: E(): 1.8e-19, 48.06% id in 129 aa; cold shock protein B 756260..756649 Corynebacterium diphtheriae NCTC 13129 2648659 NP_939143.1 CDS DIP0777 NC_002935.2 756756 757280 R Similar to Mycobacterium tuberculosis hypothetical 17.8 kDa protein Rv0875c precursor or MT0898 or MTCY31.03c SW:Y875_MYCTU (Q10537) (162 aa) fasta scores: E(): 6e-05, 25.92% id in 162 aa; hypothetical protein complement(756756..757280) Corynebacterium diphtheriae NCTC 13129 2648660 NP_939144.1 CDS DIP0778 NC_002935.2 757267 758133 R Similar to Deinococcus radiodurans glutamine cyclotransferase DR0112 TR:Q9RY39 (EMBL:AE001874) (294 aa) fasta scores: E(): 1e-28, 40.84% id in 284 aa; hypothetical protein complement(757267..758133) Corynebacterium diphtheriae NCTC 13129 2650715 NP_939145.1 CDS DIP0779 NC_002935.2 758173 758937 D Similar to Mycobacterium leprae hypothetical 28.2 kDa protein ML2142 or MLCB57.29 TR:O33058 (EMBL:Z99494) (269 aa) fasta scores: E(): 5.4e-18, 43.55% id in 225 aa; hypothetical protein 758173..758937 Corynebacterium diphtheriae NCTC 13129 2650806 NP_939146.1 CDS DIP0780 NC_002935.2 759111 760598 D Similar to Streptomyces coelicolor integral membrane protein SCD12A.17 TR:Q9KXM3 (EMBL:AL357524) (485 aa) fasta scores: E(): 4.6e-64, 46.04% id in 493 aa; hypothetical protein 759111..760598 Corynebacterium diphtheriae NCTC 13129 2650807 NP_939147.1 CDS DIP0781 NC_002935.2 760677 761573 D Similar to Mycobacterium tuberculosis hypothetical tRNA/rRNA methyltransferase Rv0881 or MT0904 or MTCY31.09 SW:Y881_MYCTU (Q10543) (288 aa) fasta scores: E(): 2.5e-52, 53.16% id in 284 aa; methyltransferase 760677..761573 Corynebacterium diphtheriae NCTC 13129 2650808 NP_939148.1 CDS DIP0782 NC_002935.2 761570 762466 R hypothetical protein complement(761570..762466) Corynebacterium diphtheriae NCTC 13129 2650242 NP_939149.1 CDS DIP0783 NC_002935.2 762487 763536 R Similar to Mycobacterium leprae hypothetical 27.4 kDa protein ML2137 or MLCB57.36c TR:O33061 (EMBL:Z99494) (251 aa) fasta scores: E(): 1.4e-17, 33.45% id in 284 aa; hypothetical protein complement(762487..763536) Corynebacterium diphtheriae NCTC 13129 2650243 NP_939150.1 CDS DIP0784 NC_002935.2 763738 764868 R catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; phosphoserine aminotransferase complement(763738..764868) Corynebacterium diphtheriae NCTC 13129 2650244 NP_939151.2 CDS gltA NC_002935.2 765550 766848 D type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase 765550..766848 Corynebacterium diphtheriae NCTC 13129 2650245 NP_939152.1 CDS DIP0786 NC_002935.2 767015 767374 D Similar to Corynebacterium glutamicum probable FK506-binding protein SW:FKBP_CORGL (P42458) (118 aa) fasta scores: E(): 8.4e-38, 82.05% id in 117 aa, and to Escherichia coli FkbP-type peptidyl-prolyl cis-trans isomerase FkpA precursor or B3347 SW:FKBA_ECOLI (P45523) (270 aa) fasta scores: E(): 2.3e-09, 42.71% id in 103 aa; FK506-binding protein 767015..767374 Corynebacterium diphtheriae NCTC 13129 2650246 NP_939153.1 CDS accDA NC_002935.2 767461 768966 R Similar to Corynebacterium glutamicum carboxyltransferase subunit of acetyl-CoA carboxylase AccDA TR:CAC42827 (EMBL:Y17592) (491 aa) fasta scores: E(): 8.9e-58, 55.31% id in 499 aa, and to Escherichia coli acetyl-coenzyme A carboxylase carboxyl transferase subunit beta AccD or DedB or Usg or B2316 or Z3578 or ECS3200 SW:ACCD_ECOLI (P08193) (304 aa) fasta scores: E(): 8.6e-22, 34.89% id in 235 aa; carboxyltransferase subunit of acetyl-CoA carboxylase complement(767461..768966) Corynebacterium diphtheriae NCTC 13129 2650247 NP_939154.1 CDS DIP0788 NC_002935.2 769059 769931 D Similar to Streptomyces coelicolor oxidoreductase SC4B5.01c TR:Q9ZBW7 (EMBL:AL034443) (277 aa) fasta scores: E(): 1.3e-48, 48% id in 275 aa, and to Corynebacterium sp 2,5-diketo-D-gluconic acid reductase SW:2DKG_CORSP (P15339) (277 aa) fasta scores: E(): 1.1e-39, 44.52% id in 274 aa; oxidoreductase 769059..769931 Corynebacterium diphtheriae NCTC 13129 2650248 NP_939155.1 CDS DIP0789 NC_002935.2 769931 770707 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 769931..770707 Corynebacterium diphtheriae NCTC 13129 2650249 NP_939156.1 CDS DIP0790 NC_002935.2 771056 771397 D Similar to Streptomyces coelicolor integral membrane protein SCI8.08c TR:Q9RJ45 (EMBL:AL132644) (124 aa) fasta scores: E(): 2.6e-18, 43.63% id in 110 aa; hypothetical protein 771056..771397 Corynebacterium diphtheriae NCTC 13129 2650250 NP_939157.1 CDS DIP0791 NC_002935.2 771401 773053 D Similar to Streptomyces coelicolor transmembrane transport protein SCI8.07c TR:Q9RJ46 (EMBL:AL132644) (544 aa) fasta scores: E(): 4.2e-82, 58.31% id in 547 aa; transport membrane protein 771401..773053 Corynebacterium diphtheriae NCTC 13129 2650251 NP_939158.1 CDS DIP0792 NC_002935.2 773178 774032 D hypothetical protein 773178..774032 Corynebacterium diphtheriae NCTC 13129 2648627 NP_939159.1 CDS DIP0793 NC_002935.2 774025 774933 R Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT2601 TR:AAK46909 (EMBL:AE007096) (240 aa) fasta scores: E(): 4.3e-31, 46.31% id in 244 aa. Note: Contains a twin-arginine translocation (TAT) system recognition motif (RRSFLT) at the N-terminal region; hypothetical protein complement(774025..774933) Corynebacterium diphtheriae NCTC 13129 2648628 NP_939160.1 CDS DIP0794 NC_002935.2 775062 776261 R Similar to Streptomyces coelicolor integral membrane efflux protein SCE39.29 TR:Q9X8F2 (EMBL:AL049573) (404 aa) fasta scores: E(): 7.7e-37, 35.500% id in 400 aa, and to Enterococcus hirae Na(+)/H(+) antiporter NapA SW:NAPA_ENTHR (P26235) (383 aa) fasta scores: E(): 7.5e-12, 21.964% id in 387 aa; Na(+)/H(+) antiporter-like protein complement(775062..776261) Corynebacterium diphtheriae NCTC 13129 2648629 NP_939161.1 CDS DIP0795 NC_002935.2 776521 776973 R hypothetical protein complement(776521..776973) Corynebacterium diphtheriae NCTC 13129 2648630 NP_939162.1 CDS DIP0796 NC_002935.2 776985 777551 R Similar to bacteriophage bIL311 ORF21 TR:Q9AZG0 (EMBL:AF323672) (306 aa) fasta scores: E(): 0.048, 28.030% id in 132 aa; hypothetical protein complement(776985..777551) Corynebacterium diphtheriae NCTC 13129 2648631 NP_939163.1 CDS DIP0797 NC_002935.2 777583 777750 R hypothetical protein complement(777583..777750) Corynebacterium diphtheriae NCTC 13129 2648632 NP_939164.1 CDS DIP0798 NC_002935.2 777872 778144 R hypothetical protein complement(777872..778144) Corynebacterium diphtheriae NCTC 13129 2648633 NP_939165.1 CDS DIP0799 NC_002935.2 778157 778477 D hypothetical protein 778157..778477 Corynebacterium diphtheriae NCTC 13129 2648634 NP_939166.1 CDS DIP0800 NC_002935.2 778799 779374 D hypothetical protein 778799..779374 Corynebacterium diphtheriae NCTC 13129 2648635 NP_939167.1 CDS DIP0801 NC_002935.2 779748 780104 D hypothetical protein 779748..780104 Corynebacterium diphtheriae NCTC 13129 2648636 NP_939168.1 CDS DIP0802 NC_002935.2 780077 780574 R Similar to bacteriophage bIL311 ORF21 TR:Q9AZG0 (EMBL:AF323672) (306 aa) fasta scores: E(): 0.0075, 25.203% id in 123 aa; hypothetical protein complement(780077..780574) Corynebacterium diphtheriae NCTC 13129 2648637 NP_939169.1 CDS DIP0803 NC_002935.2 780837 781160 R hypothetical protein complement(780837..781160) Corynebacterium diphtheriae NCTC 13129 2648638 NP_939170.1 CDS DIP0804 NC_002935.2 781172 783724 R hypothetical protein complement(781172..783724) Corynebacterium diphtheriae NCTC 13129 2648639 NP_939171.1 CDS DIP0805 NC_002935.2 783728 785731 R Similar to Haemophilus influenzae type III restriction-modification system HinDVIp enzyme Mod HI1056 SW:T3MH_HAEIN (P71366) (629 aa) fasta scores: E(): 8.3e-26, 29.960% id in 504 aa, and to Lactococcus lactis modification methylase LlaFI Mod TR:Q9Z6H7 (EMBL:AF054600) (680 aa) fasta scores: E(): 5.8e-13, 29.369% id in 412 aa; DNA methylase complement(783728..785731) Corynebacterium diphtheriae NCTC 13129 2648640 NP_939172.1 CDS DIP0806 NC_002935.2 786230 786958 D Similar to Bacteriophage P1 hypothetical 19.9 kDa protein TR:Q9XJP4 (EMBL:AF137370) (166 aa) fasta scores: E(): 8.2e-09, 28.467% id in 137 aa; hypothetical protein 786230..786958 Corynebacterium diphtheriae NCTC 13129 2648641 NP_939173.1 CDS DIP0807 NC_002935.2 786955 787392 D hypothetical protein 786955..787392 Corynebacterium diphtheriae NCTC 13129 2648642 NP_939174.1 CDS DIP0808 NC_002935.2 787574 787945 R hypothetical protein complement(787574..787945) Corynebacterium diphtheriae NCTC 13129 2648643 NP_939175.1 CDS DIP0809 NC_002935.2 787932 788174 R hypothetical protein complement(787932..788174) Corynebacterium diphtheriae NCTC 13129 2648644 NP_939176.1 CDS DIP0810 NC_002935.2 788227 788601 R hypothetical protein complement(788227..788601) Corynebacterium diphtheriae NCTC 13129 2648645 NP_939177.1 CDS DIP0811 NC_002935.2 788588 788956 R hypothetical protein complement(788588..788956) Corynebacterium diphtheriae NCTC 13129 2648646 NP_939178.1 CDS DIP0812 NC_002935.2 788946 789917 R hypothetical protein complement(788946..789917) Corynebacterium diphtheriae NCTC 13129 2648647 NP_939179.1 CDS DIP0813 NC_002935.2 789916 790419 D hypothetical protein 789916..790419 Corynebacterium diphtheriae NCTC 13129 2649989 NP_939180.1 CDS DIP0816 NC_002935.2 790442 790960 D hypothetical protein 790442..790960 Corynebacterium diphtheriae NCTC 13129 2649990 NP_939181.1 CDS DIP0817 NC_002935.2 790953 792017 D Similar to Mycobacterium tuberculosis probable integrase/recombinase XerC or Rv2894c or MT2962 or MTCY274.25c SW:XERC_MYCTU (Q10815) (298 aa) fasta scores: E(): 3.7, 24.904% id in 261 aa; phage integrase 790953..792017 Corynebacterium diphtheriae NCTC 13129 2649991 NP_939182.1 CDS DIP0818 NC_002935.2 792350 792688 R hypothetical protein complement(792350..792688) Corynebacterium diphtheriae NCTC 13129 2649992 NP_939183.1 CDS DIP0819 NC_002935.2 792701 793471 D hypothetical protein 792701..793471 Corynebacterium diphtheriae NCTC 13129 2649993 NP_939184.1 CDS DIP0820 NC_002935.2 793522 795300 D hypothetical protein 793522..795300 Corynebacterium diphtheriae NCTC 13129 2650534 NP_939185.1 CDS DIP0821 NC_002935.2 795749 796081 D hypothetical protein 795749..796081 Corynebacterium diphtheriae NCTC 13129 2650536 NP_939186.1 CDS DIP0822 NC_002935.2 796088 796840 D catalyzes the formation of precorrin 6x from precorrin 5; precorrin 6A synthase 796088..796840 Corynebacterium diphtheriae NCTC 13129 2650537 NP_939187.1 CDS DIP0823 NC_002935.2 796859 797116 R Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT3292 TR:AAK47635 (EMBL:AE007142) (84 aa) fasta scores: E(): 4.4e-12, 48.1% id in 79 aa; hypothetical protein complement(796859..797116) Corynebacterium diphtheriae NCTC 13129 2650538 NP_939188.1 CDS DIP0824 NC_002935.2 797137 797640 R Similar to Mycobacterium avium dihydrofolate reductase FolA TR:O30463 (EMBL:AF006616) (181 aa) fasta scores: E(): 2e-22, 46.1% id in 167 aa, and to Escherichia coli dihydrofolate reductase FolA or TmrA or B0048 SW:DYR_ECOLI (P00379) (159 aa) fasta scores: E(): 1.5e-13, 42.76% id in 152 aa; folate reductase complement(797137..797640) Corynebacterium diphtheriae NCTC 13129 2650539 NP_939189.1 CDS thyA NC_002935.2 797640 798452 R ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase complement(797640..798452) Corynebacterium diphtheriae NCTC 13129 2650540 NP_939190.1 CDS DIP0826 NC_002935.2 798546 799304 R Similar to Mycobacterium tuberculosis CysQ protein homolog or Rv2131c or MT2189 or MTCY270.37 SW:CYSQ_MYCTU (O06244) (267 aa) fasta scores: E(): 9.2e-23, 52.51% id in 259 aa; sulfite synthesis-like protein complement(798546..799304) Corynebacterium diphtheriae NCTC 13129 2650541 NP_939191.1 CDS DIP0827 NC_002935.2 799343 804157 D Similar to Escherichia coli probable ATP-dependent helicase Lhr or RhlF or B1653 SW:LHR_ECOLI (P30015) (1538 aa) fasta scores: E(): 1.4e-134, 46.42% id in 1579 aa; ATP-dependent helicase 799343..804157 Corynebacterium diphtheriae NCTC 13129 2650542 NP_939192.1 CDS DIP0828 NC_002935.2 804154 804705 R Similar to Streptomyces coelicolor G/U mismatch-specific DNA glycosylase Mug TR:Q9K3I5 (EMBL:AL390188) (160 aa) fasta scores: E(): 1.6e-21, 46.49% id in 157 aa, and to Escherichia coli G/U mismatch-specific DNA glycosylase Mug or B3068 SW:MUG_ECOLI (P43342) (168 aa) fasta scores: E(): 1.1e-15, 36.84% id in 171 aa; DNA repair protein complement(804154..804705) Corynebacterium diphtheriae NCTC 13129 2650543 NP_939193.1 CDS DIP0829 NC_002935.2 804836 805642 D Similar to Streptomyces coelicolor endonuclease VIII Nei or SC7C7.15c SW:END8_STRCO (O86820) (276 aa) fasta scores: E(): 2.5e-39, 40.87% id in 274 aa, and to Escherichia coli endonuclease VIII Nei or B0714 SW:END8_ECOLI (P50465) (262 aa) fasta scores: E(): 4.6e-14, 28.88% id in 277 aa; endonuclease 804836..805642 Corynebacterium diphtheriae NCTC 13129 2649291 NP_939194.1 CDS DIP0830 NC_002935.2 805625 807250 R Similar to Escherichia coli hypothetical 58.9 kDa protein YidE or B3685 SW:YIDE_ECOLI (P29211) (553 aa) fasta scores: E(): 1.8e-44, 33.21% id in 554 aa; hypothetical protein complement(805625..807250) Corynebacterium diphtheriae NCTC 13129 2649292 NP_939195.1 CDS DIP0831 NC_002935.2 807364 807777 D Similar to Streptomyces coelicolor integral membrane protein SCD39.10 TR:Q9F2V1 (EMBL:AL392146) (138 aa) fasta scores: E(): 8.5e-26, 54.26% id in 129 aa; hypothetical protein 807364..807777 Corynebacterium diphtheriae NCTC 13129 2649293 NP_939196.1 CDS pgi NC_002935.2 807862 809505 R functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase complement(807862..809505) Corynebacterium diphtheriae NCTC 13129 2649294 NP_939197.1 CDS DIP0833 NC_002935.2 809708 811192 D Similar to Escherichia coli succinate-semialdehyde dehydrogenase [NADP+] GabD or B2661 SW:GABD_ECOLI (P25526) (482 aa) fasta scores: E(): 2.9e-76, 44.37% id in 471 aa; succinate-semialdehyde dehydrogenase 809708..811192 Corynebacterium diphtheriae NCTC 13129 2649295 NP_939198.1 CDS DIP0834 NC_002935.2 811189 811521 R Similar to Mycobacterium tuberculosis hypothetical 11.8 kDa protein Rv0948c or MT0975 or MTCY10D7.26 SW:Y948_MYCTU (P71562) (105 aa) fasta scores: E(): 1.6e-14, 62.35% id in 85 aa; hypothetical protein complement(811189..811521) Corynebacterium diphtheriae NCTC 13129 2649296 NP_939199.1 CDS pcrA NC_002935.2 811671 814088 D Similar to Mycobacterium leprae ATP-dependent DNA helicase PcrA or UvrD or ML0153 SW:PCRA_MYCLE (Q9CD72) (778 aa) fasta scores: E(): 5.7e-165, 59.08% id in 804 aa, and to Bacillus subtilis ATP-dependent DNA helicase PcrA SW:PCRA_BACSU (O34580) (739 aa) fasta scores: E(): 4.1e-80, 42.76% id in 802 aa; ATP-dependent DNA helicase 811671..814088 Corynebacterium diphtheriae NCTC 13129 2649297 NP_939200.1 CDS DIP0836 NC_002935.2 814166 814882 R Similar to C-terminal region of Mycobacterium tuberculosis CDC1551 peptidase, M23/M37 family MT0977 TR:AAK45225 (EMBL:AE006983) (332 aa) fasta scores: E(): 2.2e-33, 45.25% id in 232 aa; hypothetical protein complement(814166..814882) Corynebacterium diphtheriae NCTC 13129 2649298 NP_939201.1 CDS DIP0837 NC_002935.2 815288 816742 D Low similarity to Mycobacterium tuberculosis hypothetical 46.1 kDa protein Rv0955 or MT0982 or MTCY10D7.19c SW:Y955_MYCTU (P71555) (455 aa) fasta scores: E(): 1.9e-17, 28.01% id in 439 aa; hypothetical protein 815288..816742 Corynebacterium diphtheriae NCTC 13129 2649299 NP_939202.1 CDS purN NC_002935.2 816768 817391 D glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 816768..817391 Corynebacterium diphtheriae NCTC 13129 2649300 NP_939203.1 CDS purH NC_002935.2 817381 818958 D involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 817381..818958 Corynebacterium diphtheriae NCTC 13129 2649301 NP_939204.1 CDS DIP0840 NC_002935.2 819223 819702 D No significant database matches. Similar to CDS downstream DIP0841 38.272% identity in 162 aa overlap; hypothetical protein 819223..819702 Corynebacterium diphtheriae NCTC 13129 2649302 NP_939205.1 CDS DIP0841 NC_002935.2 819871 820371 D No significant database matches. Similar to CDS upstream DIP0840 38.272% identity in 162 aa overlap; hypothetical protein 819871..820371 Corynebacterium diphtheriae NCTC 13129 2649303 NP_939206.1 CDS DIP0842 NC_002935.2 820408 820974 D hypothetical protein 820408..820974 Corynebacterium diphtheriae NCTC 13129 2649304 NP_939207.1 CDS DIP0843 NC_002935.2 820987 822363 R Similar to Escherichia coli possible transposase of IS1353 YahA SWALL:Q9WTH9 (EMBL:AP000342) (514 aa) fasta scores: E(): 8.7e-62, 41.25% id in 463 aa; transposase complement(820987..822363) Corynebacterium diphtheriae NCTC 13129 2649305 NP_939208.1 CDS DIP0844 NC_002935.2 822365 822775 D hypothetical protein 822365..822775 Corynebacterium diphtheriae NCTC 13129 2649306 NP_939209.1 CDS DIP0845 NC_002935.2 822822 823655 D Similar to Mycobacterium tuberculosis CDC1551 citrate lyase, beta subunit MT2573 TR:AAK46877 (EMBL:AE007094) (273 aa) fasta scores: E(): 9.7e-35, 42.42% id in 264 aa, and to Escherichia coli citrate lyase beta chain CitE or B0616 SW:CILB_ECOLI (P77770) (302 aa) fasta scores: E(): 1.8e-06, 25.83% id in 298 aa; citrate lyase 822822..823655 Corynebacterium diphtheriae NCTC 13129 2649307 NP_939210.1 CDS amtR NC_002935.2 823652 824320 R Similar to Corynebacterium glutamicum AmtR protein TR:Q9S3L4 (EMBL:AJ133719) (222 aa) fasta scores: E(): 9.6e-59, 70.18% id in 218 aa; TetR family regulatory protein complement(823652..824320) Corynebacterium diphtheriae NCTC 13129 2649308 NP_939211.1 CDS DIP0847 NC_002935.2 824445 825479 R hypothetical protein complement(824445..825479) Corynebacterium diphtheriae NCTC 13129 2649640 NP_939212.1 CDS rpsR NC_002935.2 825552 825800 R binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 complement(825552..825800) Corynebacterium diphtheriae NCTC 13129 2649641 NP_939213.1 CDS rpsN NC_002935.2 825815 826120 R located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 complement(825815..826120) Corynebacterium diphtheriae NCTC 13129 2649642 NP_939214.1 CDS rpmG NC_002935.2 826124 826288 R in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 complement(826124..826288) Corynebacterium diphtheriae NCTC 13129 2649643 NP_939215.1 CDS rpmB NC_002935.2 826292 826528 R required for 70S ribosome assembly; 50S ribosomal protein L28 complement(826292..826528) Corynebacterium diphtheriae NCTC 13129 2649644 NP_939216.1 CDS rpmE2 NC_002935.2 826998 827264 D RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 826998..827264 Corynebacterium diphtheriae NCTC 13129 2649645 NP_939217.1 CDS rpmF NC_002935.2 827283 827456 D some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 827283..827456 Corynebacterium diphtheriae NCTC 13129 2649646 NP_939218.1 CDS DIP0854 NC_002935.2 827685 828377 D Similar to Corynebacterium glutamicum response regulator TR:Q9F161 (EMBL:AF119221) (232 aa) fasta scores: E(): 2.4e-67, 79.31% id in 232 aa, and to Pseudomonas syringae transcriptional activator protein CopR SW:COPR_PSESM (Q02540) (227 aa) fasta scores: E(): 1.9e-32, 48% id in 225 aa; two component system response regulator 827685..828377 Corynebacterium diphtheriae NCTC 13129 2649647 NP_939219.1 CDS DIP0855 NC_002935.2 828428 829918 D Similar to Corynebacterium glutamicum sensor kinase TR:Q9F160 (EMBL:AF119221) (455 aa) fasta scores: E(): 6.5e-71, 46.98% id in 447 aa, and to Burkholderia pseudomallei sensor protein IrlS SW:IRLS_BURPS (O31396) (464 aa) fasta scores: E(): 4.6e-18, 26% id in 446 aa; two component system sensor kinase 828428..829918 Corynebacterium diphtheriae NCTC 13129 2649648 NP_939220.1 CDS DIP0856 NC_002935.2 830008 831294 D Similar to Mycobacterium tuberculosis serine protease Rv0983 or MTV044.11 SWALL:O53896 (EMBL:AL021999) (464 aa) fasta scores: E(): 3.8e-46, 43.84% id in 406 aa, and to Brucella abortus probable serine protease do-like precursor DegP or HtrA SWALL:DEGP_BRUAB (SWALL:Q44597) (513 aa) fasta scores: E(): 7.6e-25, 44.56% id in 285 aa; serine protease 830008..831294 Corynebacterium diphtheriae NCTC 13129 2649649 NP_939221.1 CDS DIP0857 NC_002935.2 831333 831920 D Similar to Mycobacterium leprae molybdenum cofactor biosynthesis protein MoaB or ML0177 or MLCB373.29 TR:Q9Z5G5 (EMBL:AL035500) (181 aa) fasta scores: E(): 8.3e-28, 60% id in 150 aa; molybdopterin biosynthesis protein 831333..831920 Corynebacterium diphtheriae NCTC 13129 2649650 NP_939222.1 CDS DIP0858 NC_002935.2 831950 832135 D Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 831950..832135 Corynebacterium diphtheriae NCTC 13129 2648534 NP_939223.1 CDS mscL NC_002935.2 832222 832626 R Similar to Mycobacterium tuberculosis large-conductance mechanosensitive channel MscL or Rv0985c or MT1013 or MTV044.13c SW:MSCL_MYCTU (O53898) (151 aa) fasta scores: E(): 3e-16, 48.5% id in 134 aa, and to Escherichia coli, and large-conductance mechanosensitive channel MscL or B3291 or Z4661 or ECS4156 SW:MSCL_ECOLI (P23867) (136 aa) fasta scores: E(): 9.2e-11, 41.3% id in 138 aa; large-conductance mechanosensitive channel complement(832222..832626) Corynebacterium diphtheriae NCTC 13129 2648535 NP_939224.1 CDS DIP0860 NC_002935.2 832733 833416 R hypothetical protein complement(832733..833416) Corynebacterium diphtheriae NCTC 13129 2648536 NP_939225.1 CDS DIP0861 NC_002935.2 833432 834016 R Similar to Mycobacterium leprae hypothetical 21.3 kDa protein ML0181 or MLCB373.33c TR:Q9Z5G2 (EMBL:AL035500) (197 aa) fasta scores: E(): 2.1e-14, 34.73% id in 190 aa; hypothetical protein complement(833432..834016) Corynebacterium diphtheriae NCTC 13129 2648537 NP_939226.1 CDS DIP0862 NC_002935.2 834145 835065 D Similar to Mycobacterium tuberculosis CDC1551 UTP--glucose-1-phosphate uridylyltransferase MT1022 TR:AAK45269 (EMBL:AE006986) (306 aa) fasta scores: E(): 3.2e-65, 64.8% id in 287 aa, and to Bacillus subtilis UTP--glucose-1-phosphate uridylyltransferase GtaB SW:GTAB_BACSU (Q05852) (292 aa) fasta scores: E(): 1.4e-32, 40.67% id in 295 aa; urydyltransferase 834145..835065 Corynebacterium diphtheriae NCTC 13129 2648538 NP_939227.1 CDS DIP0863 NC_002935.2 835162 836427 D Similar to Mycobacterium tuberculosis molybdopterin biosynthesis protein MoeA or Rv0994 or MT1023 or MTCI237.08 SW:MOEA_MYCTU (O05577) (426 aa) fasta scores: E(): 1.1e-89, 58.35% id in 425 aa, and to Escherichia coli molybdopterin biosynthesis protein MoeA or ChlE or BisB or NarE or B0827 SW:MOEA_ECOLI (P12281) (411 aa) fasta scores: E(): 1.1e-17, 29.58% id in 409 aa; molybdopterin biosynthesis protein 835162..836427 Corynebacterium diphtheriae NCTC 13129 2648539 NP_939228.1 CDS DIP0864 NC_002935.2 836463 837125 D Similar to Mycobacterium leprae possible acetyltransferase RimJ or ML0184 TR:Q9CD65 (EMBL:AL583917) (214 aa) fasta scores: E(): 3.6e-35, 47.03% id in 202 aa; acetyltransferase 836463..837125 Corynebacterium diphtheriae NCTC 13129 2648540 NP_939229.1 CDS DIP0865 NC_002935.2 837252 838388 D Similar to Mycobacterium tuberculosis hypothetical 39.5 kDa protein Rv0996 or MTCI237.10 TR:O05579 (EMBL:Z94752) (358 aa) fasta scores: E(): 1.8e-13, 30.27% id in 370 aa; hypothetical protein 837252..838388 Corynebacterium diphtheriae NCTC 13129 2648541 NP_939230.1 CDS DIP0866 NC_002935.2 838431 838844 D Similar to Mycobacterium leprae integral membrane protein ML0956 TR:Q9CCC8 (EMBL:AL583920) (169 aa) fasta scores: E(): 2.1e-11, 39.51% id in 124 aa; hypothetical protein 838431..838844 Corynebacterium diphtheriae NCTC 13129 2648542 NP_939231.1 CDS DIP0867 NC_002935.2 838831 839493 D hypothetical protein 838831..839493 Corynebacterium diphtheriae NCTC 13129 2648543 NP_939232.1 CDS DIP0868 NC_002935.2 839502 841211 R Similar to Mycobacterium leprae membrane protein ML0192 TR:Q9CD61 (EMBL:AL583917) (510 aa) fasta scores: E(): 8e-80, 42.74% id in 496 aa; hypothetical protein complement(839502..841211) Corynebacterium diphtheriae NCTC 13129 2648544 NP_939233.1 CDS betP NC_002935.2 841745 843490 D Similar to Corynebacterium glutamicum glycine betaine transporter BetP SW:BETP_CORGL (P54582) (595 aa) fasta scores: E(): 7.8e-154, 70.87% id in 563 aa, and to Bacillus subtilis glycine betaine transporter OpuD SW:OPUD_BACSU (P54417) (512 aa) fasta scores: E(): 1.1e-76, 43.52% id in 517 aa; glycine betaine transporter 841745..843490 Corynebacterium diphtheriae NCTC 13129 2648545 NP_939234.1 CDS DIP0870 NC_002935.2 843569 845032 D Similar to Staphylococcus aureus (strain N315) hypothetical protein SA2305 or SAV2517 TR:BAB58679 (EMBL:AP003137) (359 aa) fasta scores: E(): 1.3e-35, 32.55% id in 344 aa; hypothetical protein 843569..845032 Corynebacterium diphtheriae NCTC 13129 2648546 NP_939235.1 CDS DIP0871 NC_002935.2 845142 846017 D Similar to Mycobacterium tuberculosis hypothetical 29.7 kDa protein Rv1003 or MT1032 or MTCI237.19 SW:YA03_MYCTU (O05588) (285 aa) fasta scores: E(): 2.1e-51, 58.54% id in 275 aa; hypothetical protein 845142..846017 Corynebacterium diphtheriae NCTC 13129 2648547 NP_939236.1 CDS metG NC_002935.2 846041 847873 D methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 846041..847873 Corynebacterium diphtheriae NCTC 13129 2648486 NP_939237.1 CDS DIP0873 NC_002935.2 847895 848749 D Similar to Corynebacterium glutamicum Mg-dependent DNAse CGL0908 SWALL:Q8NRY3 (EMBL:AP005276) (277 aa) fasta scores: E(): 3.7e-81, 73.74% id in 278 aa, and to Mycobacterium tuberculosis hypothetical protein Ycfh Rv1008 or MTCI237.25 TR:O08343 (EMBL:Z94752) (264 aa) fasta scores: E(): 4.4e-40, 44.61% id in 260 aa; hypothetical protein 847895..848749 Corynebacterium diphtheriae NCTC 13129 2648487 NP_939238.1 CDS DIP0874 NC_002935.2 848894 850051 D Similar to Mycobacterium tuberculosis hypothetical 38.1 kDa protein Rv1009 or MTCI237.26 TR:O05594 (EMBL:Z94752) (362 aa) fasta scores: E(): 1.8e-39, 38.71% id in 372 aa; hypothetical protein 848894..850051 Corynebacterium diphtheriae NCTC 13129 2648488 NP_939239.1 CDS ksgA NC_002935.2 850103 850990 D catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 850103..850990 Corynebacterium diphtheriae NCTC 13129 2648489 NP_939240.1 CDS DIP0876 NC_002935.2 850987 851922 D catalyzes the phosphorylation of 4-diphosphocytidyl-2-C-methyl-D-erythritol in the nonmevalonate pathway of isoprenoid biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 850987..851922 Corynebacterium diphtheriae NCTC 13129 2648490 NP_939241.1 CDS DIP0877 NC_002935.2 851922 853730 D Similar to Streptomyces coelicolor ABC transporter ATP-binding subunit SCE66.26c TR:Q9K3R7 (EMBL:AL359989) (604 aa) fasta scores: E(): 2.3e-97, 54.75% id in 610 aa; ABC transporter ATP-binding protein 851922..853730 Corynebacterium diphtheriae NCTC 13129 2648491 NP_939242.1 CDS DIP0878 NC_002935.2 853749 854072 D Similar to Mycobacterium tuberculosis hypothetical 12.0 kDa protein Rv1117 or MTCY22G8.06 TR:O06569 (EMBL:Z95585) (107 aa) fasta scores: E(): 3.6e-13, 43.92% id in 107 aa; hypothetical protein 853749..854072 Corynebacterium diphtheriae NCTC 13129 2648492 NP_939243.1 CDS DIP0879 NC_002935.2 854176 854565 D hypothetical protein 854176..854565 Corynebacterium diphtheriae NCTC 13129 2648493 NP_939244.1 CDS DIP0880 NC_002935.2 854590 855129 D Similar to Xanthomonas campestris probable RNA polymerase sigma factor RfaY SW:RFAY_XANCP (P46358) (217 aa) fasta scores: E(): 9.8e-07, 32.88% id in 149 aa; RNA polymerase ECF-subfamily sigma factor 854590..855129 Corynebacterium diphtheriae NCTC 13129 2648494 NP_939245.1 CDS DIP0881 NC_002935.2 855138 856313 D hypothetical protein 855138..856313 Corynebacterium diphtheriae NCTC 13129 2648495 NP_939246.1 CDS DIP0882 NC_002935.2 856347 857252 D Similar to Mycobacterium tuberculosis CDC1551 RNA polymerase sigma factor, MT3329 TR:AAK47672 (EMBL:AE007144) (295 aa) fasta scores: E(): 1.4e-68, 61.42% id in 280 aa, and to Pseudomonas aeruginosa pao substrain OT684 pyoverdine gene transcriptional regulator PvdS TR:P72119 (EMBL:U12891) (237 aa) fasta scores: E(): 5.9e-56, 59.91% id in 237 aa; RNA polymerase sigma factor 856347..857252 Corynebacterium diphtheriae NCTC 13129 2648496 NP_939247.1 CDS DIP0883 NC_002935.2 857329 858042 R Low similarity to Escherichia coli protein PnuC or B0751 SW:PNUC_ECOLI (P31215) (239 aa) fasta scores: E(): 5e-07, 23.75% id in 240 aa; hypothetical protein complement(857329..858042) Corynebacterium diphtheriae NCTC 13129 2648497 NP_939248.1 CDS DIP0884 NC_002935.2 858062 858862 R Similar to Streptococcus pyogenes hypothetical protein SPY0567 TR:Q9A0X9 (EMBL:AE006513) (265 aa) fasta scores: E(): 6.5e-20, 32.31% id in 263 aa; hypothetical protein complement(858062..858862) Corynebacterium diphtheriae NCTC 13129 2648498 NP_939249.1 CDS DIP0885 NC_002935.2 858962 860014 D catalyzes the formation of 3-hydroxy-2-methylpropanoate from 3-hydroxy-2-methylpropanoyl-CoA; 3-hydroxyisobutyryl-CoA hydrolase 858962..860014 Corynebacterium diphtheriae NCTC 13129 2648499 NP_939250.1 CDS DIP0886 NC_002935.2 860011 861270 R hypothetical protein complement(860011..861270) Corynebacterium diphtheriae NCTC 13129 2648500 NP_939251.1 CDS DIP0887 NC_002935.2 861306 861530 R Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein complement(861306..861530) Corynebacterium diphtheriae NCTC 13129 2648501 NP_939252.1 CDS DIP0888 NC_002935.2 861538 861912 R Similar to Streptomyces coelicolor tetR-family transcriptional regulator SCF56.06 TR:Q9RD60 (EMBL:AL133424) (213 aa) fasta scores: E(): 2.9e-07, 40.51% id in 116 aa; TetR family transcriptional regulatory protein (partial) complement(861538..861912) Corynebacterium diphtheriae NCTC 13129 2648502 NP_939253.1 CDS DIP0889 NC_002935.2 862009 862128 R Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein complement(862009..862128) Corynebacterium diphtheriae NCTC 13129 2648503 NP_939254.1 CDS DIP0890 NC_002935.2 862236 862532 R Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein complement(862236..862532) Corynebacterium diphtheriae NCTC 13129 2648504 NP_939255.1 CDS DIP0892 NC_002935.2 862908 864338 R catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; involved in growth under gluconeogenic conditions and in glycolytic activity at high ATP concentrations in Corynebacterium; NAD and NADP dependent; glyceraldehyde-3-phosphate dehydrogenase complement(862908..864338) Corynebacterium diphtheriae NCTC 13129 2648505 NP_939256.1 CDS DIP0893 NC_002935.2 864602 865255 D hypothetical protein 864602..865255 Corynebacterium diphtheriae NCTC 13129 2648577 NP_939257.1 CDS DIP0894 NC_002935.2 865283 865486 D Low similarity to Arabidopsis thaliana AT2G37870 protein or T8P21.22 TR:Q9SHA0 (EMBL:AC007661) (115 aa) fasta scores: E(): 6.8, 31.66% id in 60 aa; hypothetical protein 865283..865486 Corynebacterium diphtheriae NCTC 13129 2648578 NP_939258.1 CDS DIP0895 NC_002935.2 865500 867134 R Similar to Caulobacter crescentus peptide chain release factor 3 CC1070 TR:Q9A9B9 (EMBL:AE005784) (534 aa) fasta scores: E(): 2.4e-70, 40% id in 545 aa, and to Staphylococcus aureus peptide chain release factor 3 PrfC or Rf3 SW:RF3_STAAU (O86490) (521 aa) fasta scores: E(): 2e-38, 38.57% id in 547 aa, and to Escherichia coli peptide chain release factor 3 PrfC or Tos or MiaD or B4375 or Z5976 or ECS5333 SW:RF3_ECOLI (P33998) (528 aa) fasta scores: E(): 1.6e-24, 41.94% id in 534 aa; peptide chain release factor 3 complement(865500..867134) Corynebacterium diphtheriae NCTC 13129 2648579 NP_939259.1 CDS DIP0896 NC_002935.2 867146 867955 R Similar to Streptomyces peucetius daunorubicin C-13 ketoreductase DnrU TR:Q9ZAU1 (EMBL:U77891) (287 aa) fasta scores: E(): 1.3e-16, 35.25% id in 278 aa; oxidoreductase complement(867146..867955) Corynebacterium diphtheriae NCTC 13129 2648580 NP_939260.1 CDS DIP0897 NC_002935.2 867987 868529 R Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase complement(867987..868529) Corynebacterium diphtheriae NCTC 13129 2648581 NP_939261.1 CDS DIP0898 NC_002935.2 868809 869369 D hypothetical protein 868809..869369 Corynebacterium diphtheriae NCTC 13129 2648582 NP_939262.1 CDS DIP0899 NC_002935.2 869457 869972 D Low similarity to parts of Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT0103 TR:AAK44326 (EMBL:AE006921) (287 aa) fasta scores: E(): 5.6e-09, 39.04% id in 105 aa; hypothetical protein 869457..869972 Corynebacterium diphtheriae NCTC 13129 2648583 NP_939263.1 CDS DIP0900 NC_002935.2 870146 870700 R Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase complement(870146..870700) Corynebacterium diphtheriae NCTC 13129 2648584 NP_939264.1 CDS DIP0901 NC_002935.2 870759 871376 R the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 complement(870759..871376) Corynebacterium diphtheriae NCTC 13129 2648585 NP_939265.1 CDS DIP0902 NC_002935.2 871597 873411 R Similar to the C-terminal regions of Thermotoga maritima pullulanase precursor PulA or TM1845 SW:PULA_THEMA (O33840) (843 aa) fasta scores: E(): 3.3e-67, 36.72% id in 610 aa, and of Klebsiella pneumoniae pullulanase precursor PulA SW:PULA_KLEPN (P07206) (1090 aa) fasta scores: E(): 1.2e-20, 28.94% id in 615 aa; hydrolase complement(871597..873411) Corynebacterium diphtheriae NCTC 13129 2648586 NP_939266.1 CDS prsA NC_002935.2 873535 874515 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase complement(873535..874515) Corynebacterium diphtheriae NCTC 13129 2648587 NP_939267.1 CDS glmU NC_002935.2 874524 875978 R forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase complement(874524..875978) Corynebacterium diphtheriae NCTC 13129 2648588 NP_939268.1 CDS DIP0905 NC_002935.2 876064 876960 R Similar to Pseudomonas aeruginosa probable transcriptional regulator PA3398 TR:Q9HYK6 (EMBL:AE004761) (308 aa) fasta scores: E(): 4e-18, 30.94% id in 265 aa; LysR family transcriptional regulator complement(876064..876960) Corynebacterium diphtheriae NCTC 13129 2648589 NP_939269.1 CDS DIP0906 NC_002935.2 877048 878124 D Low similarity to Streptomyces coelicolor integral membrane protein SCI35.39 TR:O88074 (EMBL:AL031541) (394 aa) fasta scores: E(): 1.8e-16, 29.34% id in 351 aa; hypothetical protein 877048..878124 Corynebacterium diphtheriae NCTC 13129 2648590 NP_939270.1 CDS DIP0907 NC_002935.2 878149 879078 D Similar to Corynebacterium glutamicum hypothetical 33.0 kDa protein in proB-proA intergenic region SW:YPRA_CORGL (P45637) (304 aa) fasta scores: E(): 7.5e-48, 45.3% id in 309 aa, and to Escherichia coli 2-ketogluconate reductase TkrA or B3553 SW:TKRA_ECOLI (P37666) (324 aa) fasta scores: E(): 1.4e-13, 31.57% id in 247 aa; reductase 878149..879078 Corynebacterium diphtheriae NCTC 13129 2648591 NP_939271.1 CDS DIP0908 NC_002935.2 879104 880714 D Similar to Corynebacterium striatum ABC transporter TetA TR:Q9Z4Q1 (EMBL:U21300) (513 aa) fasta scores: E(): 1.3e-45, 33.98% id in 509 aa; ABC transporter 879104..880714 Corynebacterium diphtheriae NCTC 13129 2648592 NP_939272.1 CDS DIP0909 NC_002935.2 880715 882502 D Similar to C-terminal region of Mycobacterium smegmatis ExiT TR:O85018 (EMBL:AF034152) (1122 aa) fasta scores: E(): 5.9e-45, 34.56% id in 596 aa, and to Streptomyces coelicolor ABC-transporter transmembrane protein SCF34.12c TR:Q9RK13 (EMBL:AL109974) (601 aa) fasta scores: E(): 1.5e-42, 33.98% id in 612 aa; ABC transporter ATP-binding protein 880715..882502 Corynebacterium diphtheriae NCTC 13129 2648593 NP_939273.1 CDS DIP0910 NC_002935.2 882775 883422 D Similar to Mycobacterium tuberculosis CDC1551 transcriptional regulator, tetR family MT1047 TR:AAK45298 (EMBL:AE006987) (202 aa) fasta scores: E(): 4.4e-45, 63.9% id in 205 aa; TetR family transcriptional regulator 882775..883422 Corynebacterium diphtheriae NCTC 13129 2648595 NP_939274.1 CDS mfd NC_002935.2 883472 887266 D Similar to Mycobacterium tuberculosis transcription-repair coupling factor Mfd or Rv1020 or MT1048 or MTCY10G2.29c SW:MFD_MYCTU (P96380) (1234 aa) fasta scores: E(): 2e-200, 57.37% id in 1234 aa, and to Escherichia coli transcription-repair coupling factor Mfd or B1114 SW:MFD_ECOLI (P30958) (1148 aa) fasta scores: E(): 7e-103, 36.52% id in 1191 aa; transcription-repair coupling factor 883472..887266 Corynebacterium diphtheriae NCTC 13129 2648596 NP_939275.1 CDS DIP0912 NC_002935.2 887323 887748 D hypothetical protein 887323..887748 Corynebacterium diphtheriae NCTC 13129 2648597 NP_939276.1 CDS DIP0913 NC_002935.2 887751 888233 D hypothetical protein 887751..888233 Corynebacterium diphtheriae NCTC 13129 2648598 NP_939277.1 CDS lysI NC_002935.2 888244 889740 R Similar to Corynebacterium glutamicum L-Lysine transport protein LysI SW:LYSI_CORGL (P35865) (501 aa) fasta scores: E(): 9.3e-131, 69.85% id in 491 aa; L-lysine transport protein complement(888244..889740) Corynebacterium diphtheriae NCTC 13129 2648599 NP_939278.1 CDS DIP0915 NC_002935.2 889839 890537 D Similar to Mycobacterium tuberculosis hypothetical 35.4 kDa protein Rv1021 or MTCY10G2.28c TR:P96379 (EMBL:Z92539) (325 aa) fasta scores: E(): 3.2e-20, 38.61% id in 202 aa; hypothetical protein 889839..890537 Corynebacterium diphtheriae NCTC 13129 2648600 NP_939279.1 CDS DIP0916 NC_002935.2 890549 891325 D Similar to Mycobacterium tuberculosis hypothetical 25.8 kDa protein LpqU or Rv1022 or MTCY10G2.27c TR:P96378 (EMBL:Z92539) (243 aa) fasta scores: E(): 7.2e-34, 46.02% id in 239 aa; hypothetical protein 890549..891325 Corynebacterium diphtheriae NCTC 13129 2648601 NP_939280.1 CDS eno NC_002935.2 891487 892764 D enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 891487..892764 Corynebacterium diphtheriae NCTC 13129 2648602 NP_939281.1 CDS DIP0918 NC_002935.2 892885 893418 D Similar to Mycobacterium tuberculosis hypothetical 24.6 kDa protein Rv1024 or MTCY10G2.25c TR:P96376 (EMBL:Z92539) (228 aa) fasta scores: E(): 1.5e-08, 31.21% id in 157 aa; hypothetical protein 892885..893418 Corynebacterium diphtheriae NCTC 13129 2649957 NP_939282.1 CDS DIP0919 NC_002935.2 893459 894025 D Similar to Mycobacterium leprae hypothetical protein ML0257 TR:Q9CD40 (EMBL:AL583917) (167 aa) fasta scores: E(): 4e-33, 59.49% id in 158 aa; hypothetical protein 893459..894025 Corynebacterium diphtheriae NCTC 13129 2649958 NP_939283.1 CDS DIP0920 NC_002935.2 894022 894972 D Similar to Mycobacterium leprae hypothetical 33.5 kDa protein ML0258 or MLCB4.02 TR:O69585 (EMBL:AL023514) (317 aa) fasta scores: E(): 9e-53, 52.56% id in 312 aa; hypothetical protein 894022..894972 Corynebacterium diphtheriae NCTC 13129 2649959 NP_939284.1 CDS DIP0921 NC_002935.2 895352 895675 D hypothetical protein 895352..895675 Corynebacterium diphtheriae NCTC 13129 2649961 NP_939285.1 CDS DIP0922 NC_002935.2 895787 896794 D Similar to Pseudomonas aeruginosa probable transcriptional regulator PA2488 TR:Q9I0Z4 (EMBL:AE004676) (254 aa) fasta scores: E(): 5.9e-10, 34.66% id in 150 aa, and to Streptomyces coelicolor araC-family transcriptional regulator SC9H11.05 TR:Q9KYN4 (EMBL:AL356592) (289 aa) fasta scores: E(): 3.3e-05, 29.49% id in 217 aa; AraC family transcriptional regulator 895787..896794 Corynebacterium diphtheriae NCTC 13129 2649962 NP_939286.1 CDS DIP0923 NC_002935.2 896926 897756 D Similar to Mycobacterium tuberculosis transmembrane protein Rv1072 or MTV017.25 TR:O53420 (EMBL:AL021897) (278 aa) fasta scores: E(): 2.4e-47, 58.21% id in 280 aa; hypothetical protein 896926..897756 Corynebacterium diphtheriae NCTC 13129 2649963 NP_939287.1 CDS DIP0924 NC_002935.2 897826 898245 R hypothetical protein complement(897826..898245) Corynebacterium diphtheriae NCTC 13129 2649964 NP_939288.1 CDS greA NC_002935.2 898245 898766 R necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA complement(898245..898766) Corynebacterium diphtheriae NCTC 13129 2649965 NP_939289.1 CDS DIP0926 NC_002935.2 898944 899411 R Similar to Mycobacterium leprae conserved membrane protein ML2392 TR:Q9CB66 (EMBL:AL583925) (144 aa) fasta scores: E(): 6.2e-10, 33.56% id in 143 aa; hypothetical protein complement(898944..899411) Corynebacterium diphtheriae NCTC 13129 2649966 NP_939290.1 CDS DIP0927 NC_002935.2 899713 900600 D Similar to Mycobacterium leprae LmbE (hypothetical protein ML2391) TR:Q50060 (EMBL:U15183) (290 aa) fasta scores: E(): 9e-62, 55.17% id in 290 aa; hypothetical protein 899713..900600 Corynebacterium diphtheriae NCTC 13129 2649967 NP_939291.1 CDS DIP0928 NC_002935.2 900655 900996 D hypothetical protein 900655..900996 Corynebacterium diphtheriae NCTC 13129 2649968 NP_939292.1 CDS DIP0929 NC_002935.2 901021 901818 D Similar to Mycobacterium leprae possible undecaprenyl pyrophosphate synthetase ML2467 TR:Q9CB36 (EMBL:AL583925) (262 aa) fasta scores: E(): 4.1e-57, 60% id in 250 aa, and to Bacillus subtilis undecaprenyl pyrophosphate synthetase UppS SW:UPPS_BACSU (O31751) (260 aa) fasta scores: E(): 2.1e-26, 36.84% id in 247 aa; undecaprenyl pyrophosphate synthetase 901021..901818 Corynebacterium diphtheriae NCTC 13129 2649969 NP_939293.1 CDS DIP0930 NC_002935.2 901865 902365 D hypothetical protein 901865..902365 Corynebacterium diphtheriae NCTC 13129 2649970 NP_939294.1 CDS coaA NC_002935.2 902362 903288 R catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase complement(902362..903288) Corynebacterium diphtheriae NCTC 13129 2649971 NP_939295.1 CDS glyA NC_002935.2 903498 904787 D catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 903498..904787 Corynebacterium diphtheriae NCTC 13129 2649972 NP_939296.1 CDS DIP0933 NC_002935.2 904858 905202 R Similar to Streptomyces coelicolor hypothetical 14.7 kDa protein 2SCG38.16 TR:Q9EX03 (EMBL:AL445503) (132 aa) fasta scores: E(): 1.2e-18, 53.39% id in 103 aa; hypothetical protein complement(904858..905202) Corynebacterium diphtheriae NCTC 13129 2649973 NP_939297.1 CDS DIP0934 NC_002935.2 905267 905947 D Low similarity to Streptomyces coelicolor regulatory protein 2SCG38.15c TR:Q9EX04 (EMBL:AL445503) (278 aa) fasta scores: E(): 2.1e-10, 28.39% id in 236 aa; hypothetical protein 905267..905947 Corynebacterium diphtheriae NCTC 13129 2649974 NP_939298.1 CDS DIP0935 NC_002935.2 906029 906595 D Similar to Alcaligenes faecalis phosphinothricin N-acetyltransferase Bar SW:PAT_ALCFA (P31668) (197 aa) fasta scores: E(): 7.8e-08, 31.176% identity in 170 aa overlap and to Streptomyces coelicolor phosphinothricin N-acetyltransferase Bar or SCE22.20 SW:PAT_STRCO (P21861) (171 aa) fasta scores: E(): 5.3e-07, 25.56% id in 176 aa; phosphinothricin N-acetyltransferase 906029..906595 Corynebacterium diphtheriae NCTC 13129 2649975 NP_939299.1 CDS DIP0936 NC_002935.2 906600 908165 R Similar to Streptomyces coelicolor integral membrane transport protein SCC8A.02c TR:Q9KY46 (EMBL:AL356892) (689 aa) fasta scores: E(): 8.5e-70, 42.83% id in 523 aa, and to Mycobacterium tuberculosis CDC1551 drug transporter MT1926 TR:AAK46198 (EMBL:AE007049) (687 aa) fasta scores: E(): 1.1e-57, 37.45% id in 518 aa; drug transport membrane protein complement(906600..908165) Corynebacterium diphtheriae NCTC 13129 2649976 NP_939300.1 CDS DIP0937 NC_002935.2 908167 908814 R Similar to Streptomyces coelicolor tetR-family transcriptional regulator SCF56.06 TR:Q9RD60 (EMBL:AL133424) (213 aa) fasta scores: E(): 4.4e-06, 35.59% id in 118 aa; TetR family transcriptional regulator complement(908167..908814) Corynebacterium diphtheriae NCTC 13129 2649977 NP_939301.1 CDS fumC NC_002935.2 908959 910362 R class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase complement(908959..910362) Corynebacterium diphtheriae NCTC 13129 2649978 NP_939302.1 CDS glpX NC_002935.2 910620 911636 R type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II complement(910620..911636) Corynebacterium diphtheriae NCTC 13129 2649979 NP_939303.1 CDS DIP0940 NC_002935.2 911934 912518 D Low similarity to Mycobacterium tuberculosis hypothetical 24.6 kDa protein Rv1100 or MTV017.53 TR:O53448 (EMBL:AL021897) (233 aa) fasta scores: E(): 8e-06, 28.92% id in 204 aa; hypothetical protein 911934..912518 Corynebacterium diphtheriae NCTC 13129 2649980 NP_939304.1 CDS xseB NC_002935.2 912528 912785 R catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit complement(912528..912785) Corynebacterium diphtheriae NCTC 13129 2649981 NP_939305.1 CDS xseA NC_002935.2 912814 914055 R bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit complement(912814..914055) Corynebacterium diphtheriae NCTC 13129 2649982 NP_939306.1 CDS ispH NC_002935.2 914162 915163 D catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 914162..915163 Corynebacterium diphtheriae NCTC 13129 2649983 NP_939307.1 CDS DIP0944 NC_002935.2 915227 916018 R hypothetical protein complement(915227..916018) Corynebacterium diphtheriae NCTC 13129 2649515 NP_939308.1 CDS DIP0945 NC_002935.2 916085 917503 R Similar to Streptomyces coelicolor integral membrane protein SCF6.09 TR:Q9RJL9 (EMBL:AL121849) (363 aa) fasta scores: E(): 2e-46, 44.73% id in 342 aa, and to Escherichia coli permease perm PerM or B2493 or Z3755 or ECS3355 SW:PERM_ECOLI (P77406) (353 aa) fasta scores: E(): 4.7e-17, 29.2% id in 339 aa; hypothetical protein complement(916085..917503) Corynebacterium diphtheriae NCTC 13129 2649516 NP_939309.1 CDS DIP0946 NC_002935.2 917593 917763 R hypothetical protein complement(917593..917763) Corynebacterium diphtheriae NCTC 13129 2649517 NP_939310.1 CDS DIP0947 NC_002935.2 917763 919412 R Similar to Pasteurella multocida hypothetical protein PM0718 TR:Q9CMU0 (EMBL:AE006109) (502 aa) fasta scores: E(): 6.7e-106, 57.72% id in 492 aa, and to Haemophilus influenzae hypothetical sodium-dependent transporter HI0736 SW:Y736_HAEIN (P44849) (508 aa) fasta scores: E(): 2.9e-104, 55.17% id in 502 aa; sodium-dependent ABC transport system membrane protein complement(917763..919412) Corynebacterium diphtheriae NCTC 13129 2649518 NP_939311.1 CDS DIP0948 NC_002935.2 919766 920851 D translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 919766..920851 Corynebacterium diphtheriae NCTC 13129 2649519 NP_939312.1 CDS DIP0949 NC_002935.2 920928 921842 R Similar to Deinococcus radiodurans conserved hypothetical protein DR1297 TR:Q9RUT5 (EMBL:AE001977) (311 aa) fasta scores: E(): 2.2e-57, 51.92% id in 312 aa, and to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT3176.1 TR:AAK47515 (EMBL:AE007134) (306 aa) fasta scores: E(): 5.1e-55, 54.54% id in 297 aa; ABC transporter complement(920928..921842) Corynebacterium diphtheriae NCTC 13129 2649520 NP_939313.1 CDS DIP0950 NC_002935.2 921923 922816 D ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase 921923..922816 Corynebacterium diphtheriae NCTC 13129 2649521 NP_939314.1 CDS DIP0951 NC_002935.2 922958 923551 D Similar to Bacillus subtilis YkoE TR:O34738 (EMBL:AJ002571) (199 aa) fasta scores: E(): 5.8e-16, 39.36% id in 188 aa; hypothetical protein 922958..923551 Corynebacterium diphtheriae NCTC 13129 2649522 NP_939315.1 CDS DIP0952 NC_002935.2 923566 924588 R Similar to Neisseria meningitidis chloride channel protein-related protein NMB0982 TR:Q9JZM8 (EMBL:AE002449) (380 aa) fasta scores: E(): 1.4e-21, 31.25% id in 352 aa; chloride channel related membrane protein complement(923566..924588) Corynebacterium diphtheriae NCTC 13129 2649523 NP_939316.1 CDS DIP0953 NC_002935.2 924885 926264 D Similar to Staphylococcus aureus (strain N315) SA0928 protein or SAV1076 TR:BAB57238 (EMBL:AP003132) (466 aa) fasta scores: E(): 6.9e-32, 34.18% id in 433 aa; ABC transporter ATP-binding protein 924885..926264 Corynebacterium diphtheriae NCTC 13129 2649524 NP_939317.1 CDS DIP0954 NC_002935.2 926261 927016 D Low similarity to Bacillus subtilis YkoC TR:O34572 (EMBL:AJ002571) (254 aa) fasta scores: E(): 1.3e-06, 24.48% id in 241 aa; ABC transporter 926261..927016 Corynebacterium diphtheriae NCTC 13129 2649525 NP_939318.1 CDS DIP0955 NC_002935.2 927013 927471 D hypothetical protein 927013..927471 Corynebacterium diphtheriae NCTC 13129 2649526 NP_939319.1 CDS DIP0956 NC_002935.2 927733 929322 D Similar to Corynebacterium glutamicum ABC-type transporter, periplasmic component CGL1990 SWALL:Q8NP35 (EMBL:AP005280) (534 aa) fasta scores: E(): 7.8e-143, 66.79% id in 533 aa, and to Mycobacterium tuberculosis peptide transport system secreted peptide-binding protein Rv3666c or MTV025.014c or MT3767 SWALL:O69634 (EMBL:AL022121) (541 aa) fasta scores: E(): 6.8e-75, 49.06% id in 534 aa, and to Bacillus subtilis dipeptide-binding protein precursor DppE or DciAE SWALL:DPPE_BACSU (SWALL:P26906) (543 aa) fasta scores: E(): 1.2e-18, 24.49% id in 539 aa; peptide transport system secreted protein 927733..929322 Corynebacterium diphtheriae NCTC 13129 2649527 NP_939320.1 CDS DIP0957 NC_002935.2 929413 930339 D Similar to Mycobacterium tuberculosis peptide transport system permease Rv3665c or MTV025.013c TR:O69633 (EMBL:AL022121) (308 aa) fasta scores: E(): 4.9e-69, 63.48% id in 304 aa, and to Bacillus subtilis oligopeptide transport system permease OppB or Spo0KB SW:OPPB_BACSU (P24138) (311 aa) fasta scores: E(): 1.8e-37, 37.33% id in 308 aa, and to Corynebacterium glutamicum ABC-type transporter, permease components CGL1991 SWALL:Q8NP34 (EMBL:AP005280) (308 aa) fasta scores: E(): 1.5e-95, 84.09% id in 308 aa; peptide transport system membrane protein 929413..930339 Corynebacterium diphtheriae NCTC 13129 2649528 NP_939321.1 CDS DIP0958 NC_002935.2 930332 931285 D Similar to Streptomyces coelicolor peptide transport system integral membrane protein SC9E12.04 TR:Q9F351 (EMBL:AL391751) (305 aa) fasta scores: E(): 1.2e-56, 50.86% id in 289 aa, and to Bacillus subtilis oligopeptide transport system permease OppC or Spo0KC SW:OPPC_BACSU (P24139) (305 aa) fasta scores: E(): 5.5e-35, 36.86% id in 293 aa, and to Corynebacterium glutamicum ABC-type transporter, permease components CGL1992 SWALL:Q8NP33 (EMBL:AP005280) (333 aa) fasta scores: E(): 2.4e-98, 80.32% id in 310 aa; peptide transport system membrane protein 930332..931285 Corynebacterium diphtheriae NCTC 13129 2649529 NP_939322.1 CDS DIP0959 NC_002935.2 931288 932970 D Similar in its full length to Mycobacterium tuberculosis peptide ABC transporter ATP-binding protein Rv3663c or MTV025.011c TR:O69631 (EMBL:AL022121) (548 aa) fasta scores: E(): 4.5e-100, 58.27% id in 544 aa, and N-terminal region and C-termianl region both similar to Bacillus subtilis oligopeptide transport ATP-binding protein OppD or Spo0KD SW:OPPD_BACSU (P24136) (358 aa) fasta scores: E(): 3.1e-38, 46.56% id in 262 aa; peptide ABC transporter ATP-binding protein 931288..932970 Corynebacterium diphtheriae NCTC 13129 2649530 NP_939323.1 CDS DIP0960 NC_002935.2 933397 933699 D hypothetical protein 933397..933699 Corynebacterium diphtheriae NCTC 13129 2649531 NP_939324.1 CDS DIP0961 NC_002935.2 933702 934397 D Similar to Bacillus subtilis homologous to many ATP-binding transport proteins YxlF TR:P94374 (EMBL:D83026) (295 aa) fasta scores: E(): 6.4e-12, 31.22% id in 221 aa, and to Escherichia coli, and aliphatic sulfonates transport ATP-binding protein SsuB or B0933 or Z1281 or ECS1016 SW:SSUB_ECOLI (P38053) (255 aa) fasta scores: E(): 3.3e-08, 31.25% id in 208 aa; ABC transporter ATP-binding protein 933702..934397 Corynebacterium diphtheriae NCTC 13129 2649532 NP_939325.1 CDS DIP0962 NC_002935.2 934399 935547 D hypothetical protein 934399..935547 Corynebacterium diphtheriae NCTC 13129 2650690 NP_939326.1 CDS DIP0963 NC_002935.2 935552 936139 D hypothetical protein 935552..936139 Corynebacterium diphtheriae NCTC 13129 2650691 NP_939327.1 CDS DIP0964 NC_002935.2 937248 937976 R Similar to Streptomyces coelicolor hydrolase SCBAC14E8.01c TR:Q9ADJ8 (EMBL:AL590435) (228 aa) fasta scores: E(): 0.0013, 30.47% id in 233 aa; protease complement(937248..937976) Corynebacterium diphtheriae NCTC 13129 2650692 NP_939328.1 CDS arsC NC_002935.2 937977 938321 R Similar to Escherichia coli arsenate reductase ArsC or ArsG or B3503 SW:ARSC_ECOLI (P37311) (141 aa) fasta scores: E(): 1.8e-14, 48.24% id in 114 aa; arsenate reductase complement(937977..938321) Corynebacterium diphtheriae NCTC 13129 2650693 NP_939329.1 CDS DIP0966 NC_002935.2 938318 938851 R Similar to Mycobacterium tuberculosis CDC1551 hypothetical 16.6 kDa protein MT1668 TR:AAK45938 (EMBL:AE007030) (147 aa) fasta scores: E(): 1.1e-16, 39.43% id in 142 aa; hypothetical protein complement(938318..938851) Corynebacterium diphtheriae NCTC 13129 2650694 NP_939330.1 CDS DIP0967 NC_002935.2 938855 939541 R Similar to Mycobacterium tuberculosis CDC1551 hypothetical 36.6 kDa protein MT1193 TR:AAK45450 (EMBL:AE006997) (371 aa) fasta scores: E(): 7.8e-15, 33.91% id in 230 aa; hypothetical protein complement(938855..939541) Corynebacterium diphtheriae NCTC 13129 2650695 NP_939331.1 CDS DIP0969 NC_002935.2 939899 941809 D Similar to Mycobacterium tuberculosis CDC1551 GTP-binding elongation factor family protein MT1202 TR:AAK45459 (EMBL:AE006997) (628 aa) fasta scores: E(): 6.7e-148, 67.88% id in 629 aa, and to Escherichia coli GTP-binding protein TypA/BipA TypA or BipA or B3871 SW:TYPA_ECOLI (P32132) (591 aa) fasta scores: E(): 3.3e-58, 46.49% id in 613 aa; GTP-binding elongation factor 939899..941809 Corynebacterium diphtheriae NCTC 13129 2650696 NP_939332.1 CDS DIP0970 NC_002935.2 941820 943349 D Similar to Mycobacterium tuberculosis hypothetical 66.1 kDa protein LpqW or Rv1166 or MTV005.02 TR:O50422 (EMBL:AL010186) (635 aa) fasta scores: E(): 4.6e-29, 32.02% id in 381 aa; hypothetical protein 941820..943349 Corynebacterium diphtheriae NCTC 13129 2650697 NP_939333.1 CDS DIP0971 NC_002935.2 943349 944230 D Similar to Mycobacterium tuberculosis hypothetical 31.7 kDa protein Rv1170 or MTV005.06 TR:O50426 (EMBL:AL010186) (303 aa) fasta scores: E(): 3.9e-27, 40.34% id in 290 aa; hypothetical protein 943349..944230 Corynebacterium diphtheriae NCTC 13129 2650698 NP_939334.1 CDS DIP0972 NC_002935.2 944257 944637 D hypothetical protein 944257..944637 Corynebacterium diphtheriae NCTC 13129 2650699 NP_939335.1 CDS fdxA NC_002935.2 944687 945004 D Highly similar to Saccharopolyspora erythraea ferredoxin FdxA SW:FER_SACER (P24496) (105 aa) fasta scores: E(): 9.3e-32, 76.69% id in 103 aa; ferredoxin 944687..945004 Corynebacterium diphtheriae NCTC 13129 2650700 NP_939336.1 CDS DIP0974 NC_002935.2 945034 946134 D catalyzes the formation of N-succinyl-LL-2,6-diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis; N-succinyldiaminopimelate aminotransferase 945034..946134 Corynebacterium diphtheriae NCTC 13129 2650701 NP_939337.1 CDS DIP0975 NC_002935.2 946181 946912 D Similar to, although shorter than, Mycobacterium tuberculosis CDC1551 RNA pseudouridylate synthase MT3399 TR:AAK47742 (EMBL:AE007148) (305 aa) fasta scores: E(): 3.5e-23, 37.33% id in 233 aa, and similar to Escherichia coli ribosomal large subunit pseudouridine synthase A RluR or B0058 SW:RLUA_ECOLI (P39219) (218 aa) fasta scores: E(): 1.8e-07, 26.76% id in 213 aa; RNA pseudouridylate synthase 946181..946912 Corynebacterium diphtheriae NCTC 13129 2650702 NP_939338.1 CDS DIP0976 NC_002935.2 946947 947504 D hypothetical protein 946947..947504 Corynebacterium diphtheriae NCTC 13129 2650703 NP_939339.1 CDS DIP0977 NC_002935.2 947511 948695 R hypothetical protein complement(947511..948695) Corynebacterium diphtheriae NCTC 13129 2650704 NP_939340.1 CDS aroP1 NC_002935.2 948776 950188 R Similar to Corynebacterium glutamicum aromatic amino acid transport protein AroP SW:AROP_CORGL (Q46065) (463 aa) fasta scores: E(): 1.1e-91, 56.16% id in 454 aa. Possible duplication of DIP0980 (57.395% identity in 453 aa overlap); aromatic amino acid transporter complement(948776..950188) Corynebacterium diphtheriae NCTC 13129 2650705 NP_939341.1 CDS DIP0979 NC_002935.2 950252 951226 R Similar to Mycobacterium tuberculosis CDC1551 tetrahydrodipicolinate N-succinyltransferase, MT1239 TR:AAK45496 (EMBL:AE007001) (317 aa) fasta scores: E(): 1.4e-70, 66.35% id in 324 aa, and to Vibrio cholerae 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase VC2329 TR:Q9KPN7 (EMBL:AE004303) (343 aa) fasta scores: E(): 3e-53, 52.16% id in 347 aa. Similar also to DIP0981 (45.614% identity in 285 aa overlap); succinyltransferase complement(950252..951226) Corynebacterium diphtheriae NCTC 13129 2650706 NP_939342.1 CDS aroP2 NC_002935.2 951237 952601 R Similar to Corynebacterium glutamicum aromatic amino acid transport protein AroP SW:AROP_CORGL (Q46065) (463 aa) fasta scores: E(): 6.2e-118, 74.27% id in 447 aa, and to Escherichia coli gaba permease GabP or B2663 SW:GABP_ECOLI (P25527) (466 aa) fasta scores: E(): 6.2e-59, 41.03% id in 446 aa. Possible duplication of DIP0978 (57.395% identity in 453 aa overlap); aromatic amino acid transporter complement(951237..952601) Corynebacterium diphtheriae NCTC 13129 2650707 NP_939343.1 CDS DIP0981 NC_002935.2 952671 953582 R Similar to Mycobacterium tuberculosis CDC1551 tetrahydrodipicolinate N-succinyltransferase, MT1239 TR:AAK45496 (EMBL:AE007001) (317 aa) fasta scores: E(): 3.2e-46, 46.53% id in 303 aa, and C-terminal region to Corynebacterium glutamicum tetrahydrodipicolinate succinylase DapD TR:O69283 (EMBL:AJ004934) (230 aa) fasta scores: E(): 1.6e-28, 45.2% id in 219 aa. Similar also to DIP0979 (45.614% identity in 285 aa overlap); succinyltransferase complement(952671..953582) Corynebacterium diphtheriae NCTC 13129 2650708 NP_939344.1 CDS dapE NC_002935.2 953662 954759 D catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate; succinyl-diaminopimelate desuccinylase 953662..954759 Corynebacterium diphtheriae NCTC 13129 2650709 NP_939345.1 CDS DIP0983 NC_002935.2 954767 955531 D Similar in its N-terminal region to Corynebacterium glutamicum ORF2 protein TR:Q46063 (EMBL:X81379) (211 aa) fasta scores: E(): 2.5e-63, 76.66% id in 210 aa, and to Streptomyces coelicolor hypothetical 27.5 kDa protein SCP8.03 TR:Q9FBL8 (EMBL:AL390975) (252 aa) fasta scores: E(): 7.5e-60, 64.08% id in 245 aa; hypothetical protein 954767..955531 Corynebacterium diphtheriae NCTC 13129 2650710 NP_939346.1 CDS folP NC_002935.2 955524 956381 D Similar to Mycobacterium leprae dihydropteroate synthase FolP1 or FolP or ML0224 and FolP2 or ML1063 SW:DHPS_MYCLE (P46812) (291 aa) fasta scores: E(): 4.8e-57, 58.69% id in 276 aa, and to Escherichia coli dihydropteroate synthase FolP or DhpS or B3177 SW:DHPS_ECOLI (P26282) (282 aa) fasta scores: E(): 1.2e-25, 35.79% id in 257 aa; dihydropteroate synthase 955524..956381 Corynebacterium diphtheriae NCTC 13129 2650711 NP_939347.1 CDS DIP0985 NC_002935.2 956378 957127 D Similar to Streptomyces coelicolor hypothetical 34.0 kDa protein SCD95A.25c TR:Q9KXU9 (EMBL:AL357432) (314 aa) fasta scores: E(): 2.9e-29, 47.67% id in 258 aa, and to Methanothermobacter thermautotrophicus dolichyl-phosphate mannose synthase related protein MTH374 TR:O26474 (EMBL:AE000823) (291 aa) fasta scores: E(): 1.4e-08, 31.89% id in 254 aa; glucosyl-3-phosphoglycerate synthase 956378..957127 Corynebacterium diphtheriae NCTC 13129 2650712 NP_939348.1 CDS DIP0986 NC_002935.2 957132 957410 D Similar to, although shorter than, Streptomyces coelicolor secreted protein SCP8.05 TR:Q9FBL6 (EMBL:AL390975) (119 aa) fasta scores: E(): 1.1, 32.09% id in 81 aa; hypothetical protein 957132..957410 Corynebacterium diphtheriae NCTC 13129 2650713 NP_939349.1 CDS DIP0987 NC_002935.2 957488 957664 D Similar to C-terminal region of Streptomyces coelicolor conserved hypothetical protein SCP8.08 TR:Q9FBL3 (EMBL:AL390975) (74 aa) fasta scores: E(): 8.5e-11, 60.37% id in 53 aa; hypothetical protein 957488..957664 Corynebacterium diphtheriae NCTC 13129 2650714 NP_939350.1 CDS DIP0988 NC_002935.2 957691 958560 D Similar to Micromonospora griseorubida mycinamicin-resistance protein MyrA SW:MYRA_MICGR (P37000) (295 aa) fasta scores: E(): 2.8e-31, 39.51% id in 286 aa, and to Streptomyces fradiae tylosin resistance protein TlrB TR:Q9ZHQ6 (EMBL:AF055922) (280 aa) fasta scores: E(): 2.4e-30, 37.82% id in 267 aa; macrolide resistance protein 957691..958560 Corynebacterium diphtheriae NCTC 13129 2650088 NP_939351.1 CDS DIP0989 NC_002935.2 958618 960030 R Similar to the N-terminal region of Pichia jadinii beta-D-fructofuranoside fructohydrolase Inv1 TR:O94224 (EMBL:Y12659) (533 aa) fasta scores: E(): 1.5e-09, 26.33% id in 300 aa, and to the C-terminal region of Pseudomonas mucidolens endo-inulinase TR:Q9RGC0 (EMBL:AF141320) (776 aa) fasta scores: E(): 3.6e-07, 21.77% id in 473 aa; hydrolase complement(958618..960030) Corynebacterium diphtheriae NCTC 13129 2649275 NP_939352.1 CDS DIP0990 NC_002935.2 960040 960780 R Similar to Bacillus subtilis alpha-acetolactate decarboxylase AlsD SW:ALDC_BACSU (Q04777) (255 aa) fasta scores: E(): 2.1e-38, 44.78% id in 230 aa; decarboxylase (internal pH control related) complement(960040..960780) Corynebacterium diphtheriae NCTC 13129 2649276 NP_939353.1 CDS DIP0991 NC_002935.2 960833 962005 R Similar to Mycobacterium tuberculosis CDC1551 glycosyl transferase MT1250 TR:AAK45507 (EMBL:AE007001) (387 aa) fasta scores: E(): 2.9e-91, 60.72% id in 387 aa, and to Bacillus subtilis spore coat protein SA CotSA SW:CTSA_BACSU (P46915) (377 aa) fasta scores: E(): 1.6e-13, 24.37% id in 402 aa; glycosyltransferase complement(960833..962005) Corynebacterium diphtheriae NCTC 13129 2649277 NP_939354.2 CDS glgC NC_002935.2 962100 963326 D catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 962100..963326 Corynebacterium diphtheriae NCTC 13129 2649278 NP_939355.1 CDS DIP0993 NC_002935.2 963385 964062 R Similar to Mycobacterium tuberculosis CDC1551 O-methyltransferase MT1258 TR:AAK45515 (EMBL:AE007002) (215 aa) fasta scores: E(): 6e-17, 37.91% id in 182 aa; methyltransferase complement(963385..964062) Corynebacterium diphtheriae NCTC 13129 2649279 NP_939356.1 CDS DIP0994 NC_002935.2 964148 964867 D Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein is involved in heat shock, oxidative stress and virulence; RNA polymerase sigma factor SigE 964148..964867 Corynebacterium diphtheriae NCTC 13129 2650645 NP_939357.1 CDS DIP0995 NC_002935.2 964908 965321 D Similar to Mycobacterium leprae hypothetical protein ML1077 TR:Q9CCA5 (EMBL:AL583920) (139 aa) fasta scores: E(): 8e-09, 40.35% id in 114 aa; hypothetical protein 964908..965321 Corynebacterium diphtheriae NCTC 13129 2650646 NP_939358.1 CDS tatB NC_002935.2 965352 965795 D Similar to Streptomyces lividans twin arginine translocation complex component TatB TR:Q9EWB3 (EMBL:AJ292256) (158 aa) fasta scores: E(): 1.8e-05, 28.88% id in 135 aa, and to Escherichia coli Sec-independent protein translocase TatB or MttA2 or B3838 or Z5359 or ECS4767 SW:TATB_ECOLI (O69415) (171 aa) fasta scores: E(): 0.0023, 29.33% id in 150 aa; sec-independent translocase 965352..965795 Corynebacterium diphtheriae NCTC 13129 2650647 NP_939359.1 CDS DIP0997 NC_002935.2 965798 966931 R Similar to Mycobacterium tuberculosis Mrp protein homolog or Rv1229c or MT1267 or MTCI61.12c or MTV006.01c SW:MRP_MYCTU (O33225) (381 aa) fasta scores: E(): 1.4e-84, 65.21% id in 368 aa; ATP-binding protein complement(965798..966931) Corynebacterium diphtheriae NCTC 13129 2650648 NP_939360.1 CDS DIP0998 NC_002935.2 966944 967540 R Similar to Mycobacterium tuberculosis hypothetical 20.4 kDa protein Rv1231c or MTV006.03c TR:O86314 (EMBL:Z98260) (180 aa) fasta scores: E(): 4.5e-31, 60.81% id in 148 aa; hypothetical protein complement(966944..967540) Corynebacterium diphtheriae NCTC 13129 2650649 NP_939361.1 CDS DIP0999 NC_002935.2 967544 968833 R Similar to Mycobacterium tuberculosis CDC1551 hypothetical 47.3 kDa protein MT1270 TR:AAK45528 (EMBL:AE007003) (435 aa) fasta scores: E(): 5e-77, 52.51% id in 417 aa; hypothetical protein complement(967544..968833) Corynebacterium diphtheriae NCTC 13129 2650650 NP_939362.1 CDS DIP1000 NC_002935.2 968959 969468 D Similar to Mycobacterium tuberculosis hypothetical 18.6 kDa protein Rv1234 or MTV006.06 TR:O50451 (EMBL:AL021006) (175 aa) fasta scores: E(): 2.9e-27, 56.42% id in 140 aa; hypothetical protein 968959..969468 Corynebacterium diphtheriae NCTC 13129 2650651 NP_939363.1 CDS DIP1001 NC_002935.2 969480 970199 D no database matches; hypothetical protein 969480..970199 Corynebacterium diphtheriae NCTC 13129 2650652 NP_939364.2 CDS kgd NC_002935.2 970254 973967 R kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth; alpha-ketoglutarate decarboxylase complement(970254..973967) Corynebacterium diphtheriae NCTC 13129 2650653 NP_939365.1 CDS DIP1003 NC_002935.2 974130 977870 R Similar to Streptomyces coelicolor ABC transporter protein, ATP-binding component SCC57A.34c TR:Q9RDG5 (EMBL:AL136519) (1243 aa) fasta scores: E(): 3e-116, 42.18% id in 1247 aa; ABC transporter ATP-binding protein complement(974130..977870) Corynebacterium diphtheriae NCTC 13129 2650654 NP_939366.1 CDS DIP1004 NC_002935.2 977878 978708 R Similar to Mycobacterium tuberculosis hypothetical 27.6 kDa protein Rv1249c or MTV006.21c TR:O50464 (EMBL:AL021006) (262 aa) fasta scores: E(): 2.1e-15, 31.57% id in 209 aa; hypothetical protein complement(977878..978708) Corynebacterium diphtheriae NCTC 13129 2650655 NP_939367.1 CDS DIP1005 NC_002935.2 978917 979228 R Similar to part of Mycobacterium smegmatis IS1096 TnpA protein TR:Q50440 (EMBL:M76495) (413 aa) fasta scores: E(): 0.7, 29.47% id in 95 aa; transposase remnant complement(978917..979228) Corynebacterium diphtheriae NCTC 13129 2650656 NP_939368.1 CDS aroE NC_002935.2 979492 980304 R catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase complement(979492..980304) Corynebacterium diphtheriae NCTC 13129 2650657 NP_939369.1 CDS DIP1007 NC_002935.2 980324 981904 D Similar to Bacillus spBP-7. type B carboxylesterase EstA1 TR:Q9L378 (EMBL:AJ278066) (486 aa) fasta scores: E(): 3.2e-47, 34% id in 500 aa, and to Bacillus subtilis para-nitrobenzyl esterase PnbA SW:PNBA_BACSU (P37967) (489 aa) fasta scores: E(): 3.3e-49, 33.93% id in 501 aa; type B carboxylesterase 980324..981904 Corynebacterium diphtheriae NCTC 13129 2650658 NP_939370.1 CDS DIP1008 NC_002935.2 981926 982735 D hypothetical protein 981926..982735 Corynebacterium diphtheriae NCTC 13129 2650659 NP_939371.1 CDS DIP1009 NC_002935.2 982785 983597 D hypothetical protein 982785..983597 Corynebacterium diphtheriae NCTC 13129 2650660 NP_939372.1 CDS DIP1010 NC_002935.2 983606 984148 R hypothetical protein complement(983606..984148) Corynebacterium diphtheriae NCTC 13129 2650661 NP_939373.1 CDS DIP1011 NC_002935.2 984453 985370 D Similar to aldose 1-epimerases e.g. Escherichia coli O157:H7 aldose-1-epimerase ECS4802 TR:BAB38225 (EMBL:AP002567) (300 aa) fasta scores: E(): 3.1e-21, 29.09% id in 299 aa, and to Escherichia coli hypothetical protein YihR or B3879 SW:YIHR_ECOLI (P32139) (308 aa) fasta scores: E(): 7.7e-21, 30.35% id in 280 aa, and to Salmonella typhimurium aldose-1-epimerase YihR TR:Q9L7R7 (EMBL:AF220438) (280 aa) fasta scores: E(): 1.1e-13, 29.53% id in 281 aa. Contains weak match to PFAM:PF01263 Aldose 1-epimerase E: 0.089; aldose 1-epimerase 984453..985370 Corynebacterium diphtheriae NCTC 13129 2650662 NP_939374.1 CDS DIP1012 NC_002935.2 985407 987065 D Similar to Streptomyces coelicolor sodium:solute symporter SCE66.18 TR:Q9K3S5 (EMBL:AL359989) (562 aa) fasta scores: E(): 7e-115, 56.42% id in 553 aa, and to Rattus norvegicus sodium-dependent multivitamin transporter slc5a6 or smvT SW:SL56_RAT (O70247) (634 aa) fasta scores: E(): 3.3e-23, 24.2% id in 504 aa; sodium:solute symporter 985407..987065 Corynebacterium diphtheriae NCTC 13129 2650663 NP_939375.1 CDS DIP1013 NC_002935.2 987078 987359 D Similar to Streptomyces coelicolor membrane protein SCE66.19 TR:Q9K3S4 (EMBL:AL359989) (98 aa) fasta scores: E(): 6.7e-06, 46.15% id in 65 aa; hypothetical protein 987078..987359 Corynebacterium diphtheriae NCTC 13129 2650664 NP_939376.1 CDS galT NC_002935.2 987359 988489 D Similar to Escherichia coli galactose-1-phosphate uridylyltransferase GalT or GalB or B0758 SW:GAL7_ECOLI (P09148) (348 aa) fasta scores: E(): 1.2e-24, 30.34% id in 346 aa, and to Streptomyces lividans galactose-1-phosphate uridylyltransferase GalT SW:GAL7_STRLI (P13212) (354 aa) fasta scores: E(): 4.9e-30, 38.8% id in 384 aa, and to Homo sapiens galactose-1-phosphate uridylyltransferase GalT SW:GAL7_HUMAN (P07902) (379 aa) fasta scores: E(): 8.1e-29, 33.82% id in 340 aa; galactose-1-phosphate uridylyltransferase 987359..988489 Corynebacterium diphtheriae NCTC 13129 2650665 NP_939377.1 CDS galK NC_002935.2 988473 989702 D Similar to Streptomyces lividans galactokinase GalK SW:GAL1_STRLI (P13227) (397 aa) fasta scores: E(): 1.3e-27, 36.45% id in 384 aa, and to Homo sapiens galactokinase GalK1 or GalK SW:GAL1_HUMAN (P51570) (392 aa) fasta scores: E(): 3e-23, 38.29% id in 410 aa, and to Escherichia coli galactokinase GalK or GalA or B0757 or Z0927 or ECS0785 SW:GAL1_ECOLI (P06976) (381 aa) fasta scores: E(): 1e-11, 32.08% id in 399 aa; galactokinase 988473..989702 Corynebacterium diphtheriae NCTC 13129 2650666 NP_939378.1 CDS DIP1016 NC_002935.2 989756 992887 R Similar to Streptomyces coelicolor helicase SCE20.37 TR:Q9RD88 (EMBL:AL136058) (945 aa) fasta scores: E(): 5.3e-162, 46.4% id in 933 aa, and to Vibrio cholerae helicase-related protein VC0812 TR:Q9KTS6 (EMBL:AE004166) (979 aa) fasta scores: E(): 3.5e-48, 31.6% id in 674 aa; helicase complement(989756..992887) Corynebacterium diphtheriae NCTC 13129 2650667 NP_939379.1 CDS DIP1017 NC_002935.2 992898 993293 R Similar to Staphylococcus aureus (strain N315) SA2278 or SAV2490 TR:BAB58652 (EMBL:AP003137) (130 aa) fasta scores: E(): 1e-24, 56.91% id in 123 aa, and to Escherichia coli CTP pyrophosphohydrolase NudG or B1759 SW:NUDG_ECOLI (P77788) (135 aa) fasta scores: E(): 3.3e-13, 41.4% id in 128 aa; NUDIX family hydrolase complement(992898..993293) Corynebacterium diphtheriae NCTC 13129 2650668 NP_939380.1 CDS deaD NC_002935.2 993506 995548 D Similar to Mycobacterium tuberculosis cold-shock DEAD-box protein A homolog DeaD or CsdA or Rv1253 or MT1292 or MTCY50.29c SW:DEAD_MYCTU (Q11039) (563 aa) fasta scores: E(): 1.4e-97, 59.85% id in 563 aa, and to Escherichia coli cold-shock DEAD-box protein A DeaD or CsdA or MssB or B3162 SW:DEAD_ECOLI (P23304) (628 aa) fasta scores: E(): 7e-97, 50.32% id in 622 aa; DEAD/DEAH box helicase 993506..995548 Corynebacterium diphtheriae NCTC 13129 2650669 NP_939381.1 CDS DIP1019 NC_002935.2 995636 996046 D no database matches; hypothetical protein 995636..996046 Corynebacterium diphtheriae NCTC 13129 2648603 NP_939382.1 CDS DIP1020 NC_002935.2 996175 996639 R Similar to Streptomyces coelicolor integral membrane protein scf42.06C TR:Q9L2K7 (EMBL:AL137165) (164 aa) fasta scores: E(): 0.0052, 31.54% id in 168 aa, and to Rhizobium meliloti hypothetical transmembrane protein Smc01456 smc01456 TR:CAC46718 (EMBL:AL591789) (144 aa) fasta scores: E(): 0.27, 23.61% id in 144 aa; hypothetical protein complement(996175..996639) Corynebacterium diphtheriae NCTC 13129 2648604 NP_939383.1 CDS DIP1021 NC_002935.2 996688 997278 R Similar to Mycobacterium tuberculosis hypothetical 25.9 kDa protein Rv2972c or MTCY349.15 TR:P95123 (EMBL:Z83018) (237 aa) fasta scores: E(): 1.3e-16, 34.7% id in 170 aa, and to Streptomyces coelicolor secreted protein scp1.323c or scp1.31 TR:Q99QB5 (EMBL:AL590464) (219 aa) fasta scores: E(): 2.2e-13, 35.18% id in 162 aa; hypothetical protein complement(996688..997278) Corynebacterium diphtheriae NCTC 13129 2648605 NP_939384.1 CDS putP NC_002935.2 997318 998883 R Similar to Corynebacterium glutamicum proline transport system putP TR:O32355 (EMBL:Y09163) (524 aa) fasta scores: E(): 2.3e-143, 69.23% id in 520 aa, and to Escherichia coli sodium/proline symporter putP or B1015 SW:PUTP_ECOLI (P07117) (502 aa) fasta scores: E(): 2.2e-41, 45.69% id in 499 aa; sodium/proline symporter complement(997318..998883) Corynebacterium diphtheriae NCTC 13129 2648606 NP_939385.1 CDS DIP1023 NC_002935.2 999109 1002198 D Similar to Mycobacterium tuberculosis CDC1551 helicase, SNF2/RAD54 family MT2161 TR:AAK46443 (EMBL:AE007065) (954 aa) fasta scores: E(): 7.8e-94, 38.56% id in 1006 aa, and to Synechocystis sp helicase of the SNF2/RAD54 family SLL1366 TR:P74552 (EMBL:D90916) (1039 aa) fasta scores: E(): 1.9e-83, 34.17% id in 986 aa; SNF2/RAD54 family protein 999109..1002198 Corynebacterium diphtheriae NCTC 13129 2648607 NP_939386.1 CDS DIP1024 NC_002935.2 1002199 1003020 D Similar to Streptomyces coelicolor hypothetical 59.8 kDa protein orfZ TR:O86854 (EMBL:AJ007731) (566 aa) fasta scores: E(): 1.2e-07, 31.21% id in 189 aa, and to Sulfolobus solfataricus hypothetical protein Sso1656 sso1656 TR:Q97XQ4 (EMBL:AE006779) (217 aa) fasta scores: E(): 1.1e-06, 25.11% id in 211 aa; hypothetical protein 1002199..1003020 Corynebacterium diphtheriae NCTC 13129 2648608 NP_939387.1 CDS DIP1025 NC_002935.2 1003052 1004173 D Similar to Mycobacterium tuberculosis CDC1551 exonuclease SbcD-related protein MT1314 TR:AAK45575 (EMBL:AE007006) (417 aa) fasta scores: E(): 3e-43, 40.1% id in 384 aa, and to Bacillus subtilis exonuclease SbcD homolog SW:SBCD_BACSU (P23479) (325 aa) fasta scores: E(): 1.6, 27.13% id in 258 aa; exonuclease SbcD 1003052..1004173 Corynebacterium diphtheriae NCTC 13129 2648609 NP_939388.1 CDS DIP1026 NC_002935.2 1004173 1006737 D Similar to Mycobacterium leprae hypothetical protein ML1120 TR:Q9CC83 (EMBL:AL583920) (873 aa) fasta scores: E(): 1.9e-14, 28.49% id in 888 aa, and to Mycobacterium tuberculosis hypothetical 93.4 kDa protein Rv1278 or MT1315 or MTCY50.04c SW:YC78_MYCTU (Q11042) (875 aa) fasta scores: E(): 3.3e-13, 29% id in 893 aa. Contains coiled-coil domains, and thus some probably non-specific similarity to e.g. Drosophila melanogaster myosin heavy chain, non-muscle zip SW:MYSN_DROME (Q99323) (2017 aa) fasta scores: E(): 5.7e-07, 23.06% id in 568 aa; ATP-binding protein 1004173..1006737 Corynebacterium diphtheriae NCTC 13129 2648610 NP_939389.1 CDS DIP1027 NC_002935.2 1006815 1007345 R Similar to Streptomyces coelicolor hypothetical 20.0 kDa protein SC1C2.14C TR:O86515 (EMBL:AL031124) (185 aa) fasta scores: E(): 1e-29, 48.04% id in 179 aa, and to Thermoplasma volcanium hypothetical protein Tvg0219791 TR:BAB59353 (EMBL:AP000991) (177 aa) fasta scores: E(): 2.4e-28, 50.93% id in 161 aa; hypothetical protein complement(1006815..1007345) Corynebacterium diphtheriae NCTC 13129 2648611 NP_939390.1 CDS DIP1028 NC_002935.2 1007587 1008069 D Similar to Streptomyces coelicolor MarR-family transcriptional repressor SCE22.22 TR:Q9KYU1 (EMBL:AL355832) (163 aa) fasta scores: E(): 3.5e-17, 37.06% id in 143 aa, and to Escherichia coli transcriptional repressor MprA EmrR or B2684 or Z3985 or ECS3546 SW:MPRA_ECOLI (P24201) (176 aa) fasta scores: E(): 0.0011, 24.79% id in 121 aa; MarR family transcriptional regulator 1007587..1008069 Corynebacterium diphtheriae NCTC 13129 2648612 NP_939391.1 CDS DIP1029 NC_002935.2 1008175 1008375 D Similar to Streptomyces coelicolor membrane protein 2SCK8.29C TR:Q9AK23 (EMBL:AL589164) (67 aa) fasta scores: E(): 1.6e-05, 37.03% id in 54 aa, and to Thermotoga maritima conserved hypothetical protein TM1156 TR:Q9X0P0 (EMBL:AE001773) (129 aa) fasta scores: E(): 0.00055, 37.5% id in 56 aa; hypothetical protein 1008175..1008375 Corynebacterium diphtheriae NCTC 13129 2648613 NP_939392.1 CDS DIP1030 NC_002935.2 1008712 1009341 R Similar to Streptomyces coelicolor hypothetical 23.2 kDa protein SCF43A.07 TR:Q9XAA8 (EMBL:AL096837) (215 aa) fasta scores: E(): 3.3e-26, 44.65% id in 215 aa, and to Deinococcus radiodurans conserved hypothetical protein DR1909 TR:Q9RT57 (EMBL:AE002030) (212 aa) fasta scores: E(): 7.8e-17, 37.44% id in 211 aa; hypothetical protein complement(1008712..1009341) Corynebacterium diphtheriae NCTC 13129 2648615 NP_939393.1 CDS DIP1031 NC_002935.2 1009343 1010860 R Similar to Streptomyces coelicolor iron-sulfur protein SCF43A.06 TR:Q9XAA9 (EMBL:AL096837) (492 aa) fasta scores: E(): 9.1e-97, 57.35% id in 483 aa, and to Escherichia coli electron transport protein YkgF or B0307 SW:YKGF_ECOLI (P77536) (475 aa) fasta scores: E(): 5.4e-64, 39.41% id in 482 aa; iron-sulfur protein complement(1009343..1010860) Corynebacterium diphtheriae NCTC 13129 2648616 NP_939394.1 CDS DIP1032 NC_002935.2 1010884 1011669 R Similar to C-terminus of e.g. Escherichia coli anaerobic glycerol-3-phosphate dehydrogenase subunit C GlpC or B2243 or Z3501 or ECS3128 SW:GLPC_ECOLI (P13034) (396 aa) fasta scores: E(): 2.8e-11, 27.71% id in 249 aa, and to C-terminus of Escherichia coli glycolate oxidase iron-sulfur subunit GlcF or gox or B2978 SW:GLCF_ECOLI (P52074) (407 aa) fasta scores: E(): 9.8e-10, 23.27% id in 232 aa; oxididoreductase subunit complement(1010884..1011669) Corynebacterium diphtheriae NCTC 13129 2648617 NP_939395.1 CDS DIP1033 NC_002935.2 1012107 1013765 D Similar to Escherichia coli L-lactate permease LldP or LctP or B3603 SW:LLDP_ECOLI (P33231) (551 aa) fasta scores: E(): 1e-58, 36.28% id in 554 aa; L-lactate permease 1012107..1013765 Corynebacterium diphtheriae NCTC 13129 2648618 NP_939396.1 CDS argS NC_002935.2 1013777 1015429 D catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1013777..1015429 Corynebacterium diphtheriae NCTC 13129 2648619 NP_939397.1 CDS lysA NC_002935.2 1015432 1016760 D Similar to Corynebacterium glutamicum diaminopimelate decarboxylase LysA SW:DCDA_CORGL (P09890) (445 aa) fasta scores: E(): 2.8e-119, 70.61% id in 439 aa, and to Bacillus subtilis diaminopimelate decarboxylase LysA or Lys SW:DCDA_BACSU (P23630) (441 aa) fasta scores: E(): 3e-67, 43.76% id in 425 aa; diaminopimelate decarboxylase 1015432..1016760 Corynebacterium diphtheriae NCTC 13129 2648620 NP_939398.1 CDS thrA NC_002935.2 1016931 1018277 D catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase 1016931..1018277 Corynebacterium diphtheriae NCTC 13129 2648621 NP_939399.1 CDS thrB NC_002935.2 1018282 1019208 D catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 1018282..1019208 Corynebacterium diphtheriae NCTC 13129 2648622 NP_939400.1 CDS DIP1038 NC_002935.2 1019270 1021021 R activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase complement(1019270..1021021) Corynebacterium diphtheriae NCTC 13129 2648623 NP_939401.1 CDS rho NC_002935.2 1021371 1023434 D An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 1021371..1023434 Corynebacterium diphtheriae NCTC 13129 2648624 NP_939402.1 CDS prfA NC_002935.2 1023434 1024504 D recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1023434..1024504 Corynebacterium diphtheriae NCTC 13129 2648625 NP_939403.1 CDS DIP1042 NC_002935.2 1024509 1025327 D Similar to Mycobacterium tuberculosis HemK protein homolog HemK or Rv1300 or MT1339 or MTCY373.20 SW:HEMK_MYCTU (Q10602) (304 aa) fasta scores: E(): 2.7e-33, 44.24% id in 278 aa, and to Escherichia coli protein HemK or B1212 SW:HEMK_ECOLI (P37186) (277 aa) fasta scores: E(): 1.2e-16, 29.71% id in 276 aa; HemK family methytransferase 1024509..1025327 Corynebacterium diphtheriae NCTC 13129 2648626 NP_939404.1 CDS DIP1043 NC_002935.2 1025435 1026085 D Similar to Mycobacterium tuberculosis hypothetical 22.6 kDa protein Rv1301 or MT1340 or MTCY373.21 SW:YD01_MYCTU (Q10618) (217 aa) fasta scores: E(): 2.3e-50, 64.92% id in 211 aa, and to Bacillus subtilis hypothetical 37.0 kDa protein in spoIIR-glyC intergenic region YwlC or Ipc-29D SW:YWLC_BACSU (P39153) (346 aa) fasta scores: E(): 1.2e-18, 33.01% id in 206 aa; hypothetical protein 1025435..1026085 Corynebacterium diphtheriae NCTC 13129 2650809 NP_939405.1 CDS DIP1044 NC_002935.2 1026086 1027255 D Similar to Mycobacterium tuberculosis undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase Rfe or Rv1302 or MT1341 or MTCY373.22 SW:RFE_MYCTU (Q10606) (404 aa) fasta scores: E(): 1e-75, 56.91% id in 369 aa, and to Bacillus subtilis phospho-N-acetylmuramoyl-pentapeptide-transferase MraY SW:MRAY_BACSU (Q03521) (324 aa) fasta scores: E(): 3.6e-10, 26.53% id in 343 aa; glycosyl trasferase 1026086..1027255 Corynebacterium diphtheriae NCTC 13129 2650810 NP_939406.1 CDS DIP1045 NC_002935.2 1027273 1027716 D no database matches; hypothetical protein 1027273..1027716 Corynebacterium diphtheriae NCTC 13129 2650811 NP_939407.1 CDS atpB NC_002935.2 1028202 1028987 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; ATP synthase F0F1 subunit A 1028202..1028987 Corynebacterium diphtheriae NCTC 13129 2650812 NP_939408.1 CDS atpE NC_002935.2 1029073 1029312 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; ATP synthase F0F1 subunit C 1029073..1029312 Corynebacterium diphtheriae NCTC 13129 2650813 NP_939409.1 CDS atpF NC_002935.2 1029340 1029906 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; ATP synthase F0F1 subunit B 1029340..1029906 Corynebacterium diphtheriae NCTC 13129 2650814 NP_939410.1 CDS atpH NC_002935.2 1029912 1030733 D produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; ATP synthase F0F1 subunit delta 1029912..1030733 Corynebacterium diphtheriae NCTC 13129 2650815 NP_939411.1 CDS atpA NC_002935.2 1030794 1032422 D produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; ATP synthase F0F1 subunit alpha 1030794..1032422 Corynebacterium diphtheriae NCTC 13129 2650816 NP_939412.1 CDS atpG NC_002935.2 1032476 1033453 D Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; ATP synthase F0F1 subunit gamma 1032476..1033453 Corynebacterium diphtheriae NCTC 13129 2650817 NP_939413.1 CDS atpD NC_002935.2 1033457 1034902 D Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; ATP synthase F0F1 subunit beta 1033457..1034902 Corynebacterium diphtheriae NCTC 13129 2650818 NP_939414.1 CDS atpC NC_002935.2 1034916 1035287 D part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; ATP synthase F0F1 subunit epsilon 1034916..1035287 Corynebacterium diphtheriae NCTC 13129 2650819 NP_939415.1 CDS DIP1054 NC_002935.2 1035514 1035981 D Similar to Mycobacterium leprae hypothetical 16.5 kDa protein ML1147 or u471B SW:YD12_MYCLE (P53432) (147 aa) fasta scores: E(): 4.8e-12, 31.65% id in 139 aa, and to Mycobacterium tuberculosis hypothetical 16.6 kDa protein Rv1312 MT1352 or MTCY373.32 SW:YD12_MYCTU (Q10620) (147 aa) fasta scores: E(): 1.6e-11, 32.37% id in 139 aa, and to Streptomyces coelicolor secreted/membrane protein 2sc6g5.19 TR:Q9K4D3 (EMBL:AL359152) (151 aa) fasta scores: E(): 1.1e-05, 27.97% id in 143 aa; hypothetical protein 1035514..1035981 Corynebacterium diphtheriae NCTC 13129 2650820 NP_939416.1 CDS DIP1055 NC_002935.2 1036006 1036695 D Similar to Mycobacterium tuberculosis hypothetical 25.1 kDa protein Rv1321 MT1363 or MTCY130.06 SW:YD21_MYCTU (Q10634) (226 aa) fasta scores: E(): 1.8e-66, 73.79% id in 229 aa, and to Mycobacterium leprae hypothetical 24.4 kDa protein MLl1155 or B1549_c3_223 SW:YD21_MYCLE (P53524) (220 aa) fasta scores: E(): 9.1e-64, 72.56% id in 226 aa; hypothetical protein 1036006..1036695 Corynebacterium diphtheriae NCTC 13129 2650821 NP_939417.1 CDS DIP1056 NC_002935.2 1036724 1037008 D Similar to Streptomyces coelicolor ATP/GTP-binding protein, doubtful CDS 2SC6G5.35 TR:Q9K4C0 (EMBL:AL359152) (110 aa) fasta scores: E(): 1.1e-12, 46.87% id in 96 aa, and to Mycobacterium tuberculosis hypothetical 11.3 kDa protein Rv1322 MT1363.1 or MTCY130.07 SW:YD22_MYCTU (Q10635) (98 aa) fasta scores: E(): 1.4e-10, 42.22% id in 90 aa; hypothetical protein 1036724..1037008 Corynebacterium diphtheriae NCTC 13129 2650822 NP_939418.1 CDS DIP1057 NC_002935.2 1037086 1037544 R Similar to Mycobacterium leprae B1549_F2_87 ML1157 TR:Q49717 (EMBL:U00014) (155 aa) fasta scores: E(): 1.2e-28, 55.47% id in 137 aa, and to Mycobacterium tuberculosis CDC1551 4-hydroxyphenylpyruvate dioxygenase C terminal domain containing protein MT1364 TR:AAK45627 (EMBL:AE007009) (152 aa) fasta scores: E(): 3e-27, 53.28% id in 137 aa, and to Pyrococcus horikoshii methylmalonyl-CoA epimerase PHO272 TR:AAK52053 (EMBL:AF364548) (136 aa) fasta scores: E(): 9.8e-13, 38.63% id in 132 aa, and to Homo sapiens methylmalonyl-CoA epimerase TR:AAK52052 (EMBL:AF364547) (176 aa) fasta scores: E(): 2.7e-11, 36.84% id in 133 aa; methylmalonyl-CoA epimerase complement(1037086..1037544) Corynebacterium diphtheriae NCTC 13129 2650823 NP_939419.1 CDS DIP1058 NC_002935.2 1037621 1037947 D Similar to Mycobacterium tuberculosis hypothetical 11.0 kDa protein Rv1898 or MT1949 or MTCY180.20c SW:YI98_MYCTU (O07734) (102 aa) fasta scores: E(): 5.8e-16, 56.43% id in 101 aa, and to Aquifex aeolicus hypothetical 17.9 kDa protein AQ_2067 TR:O67847 (EMBL:AE000771) (157 aa) fasta scores: E(): 4.7e-08, 40.19% id in 102 aa; hypothetical protein 1037621..1037947 Corynebacterium diphtheriae NCTC 13129 2650824 NP_939420.1 CDS DIP1059 NC_002935.2 1037950 1038771 R Similar to Streptomyces coelicolor iron-siderophore uptake system ATP-binding component SCI51.25C TR:Q9S215 (EMBL:AL109848) (301 aa) fasta scores: E(): 1.9e-42, 50.58% id in 255 aa, and to Escherichia coli ferric enterobactin transport ATP-binding protein fepC b0588 SW:FEPC_ECOLI (P23878) (271 aa) fasta scores: E(): 1.1e-41, 49.61% id in 262 aa; iron-siderophore uptake system ATP-binding protein complement(1037950..1038771) Corynebacterium diphtheriae NCTC 13129 2650825 NP_939421.1 CDS DIP1060 NC_002935.2 1038768 1039727 R Similar to Streptomyces coelicolor iron-siderophore uptake system transmembrane component sci51.26C TR:Q9S214 (EMBL:AL109848) (375 aa) fasta scores: E(): 5e-40, 40.74% id in 324 aa, and to Escherichia coli ferric enterobactin transport system permease fepg fepg or B0589 SW:FEPG_ECOLI (P23877) (330 aa) fasta scores: E(): 1.8e-45, 44.09% id in 322 aa; iron-siderophore uptake system transmembrane protein complement(1038768..1039727) Corynebacterium diphtheriae NCTC 13129 2650826 NP_939422.1 CDS DIP1061 NC_002935.2 1039729 1040736 R Similar to Streptomyces coelicolor iron-siderophore uptake system transmembrane component sci51.27C TR:Q9S213 (EMBL:AL109848) (348 aa) fasta scores: E(): 8e-36, 36.53% id in 323 aa, and to Escherichia coli ferric enterobactin transport system permease fepD or B0590 SW:FEPD_ECOLI (P23876) (334 aa) fasta scores: E(): 5.2e-40, 40.37% id in 322 aa; iron-siderophore uptake system transmembrane protein complement(1039729..1040736) Corynebacterium diphtheriae NCTC 13129 2650827 NP_939423.1 CDS DIP1062 NC_002935.2 1040784 1041827 D Similar to Escherichia coli iron(III) dicitrate-binding periplasmic protein precursor FecB or B4290 SW:FECB_ECOLI (P15028) (300 aa) fasta scores: E(): 1.1e-12, 25.55% id in 270 aa, and to Campylobacter jejuni enterochelin uptake periplasmic binding protein CeuE or CJ1355 TR:Q9PMU4 (EMBL:AL139078) (330 aa) fasta scores: E(): 3e-12, 28.35% id in 328 aa, and to Vibrio anguillarum ferric anguibactin-binding protein precursor FatB SW:FATB_VIBAN (P11460) (322 aa) fasta scores: E(): 1.5e-09, 28.72% id in 289 aa; iron-siderophore uptake system exported substrate-binding protein 1040784..1041827 Corynebacterium diphtheriae NCTC 13129 2650828 NP_939424.1 CDS DIP1063 NC_002935.2 1041924 1042307 R Weakly similar to Streptomyces coelicolor membrane protein SCL2.30c TR:Q9L269 (EMBL:AL137778) (150 aa) fasta scores: E(): 0.12, 28.3% id in 106 aa; hypothetical protein complement(1041924..1042307) Corynebacterium diphtheriae NCTC 13129 2650829 NP_939425.1 CDS DIP1064 NC_002935.2 1042460 1043356 D Similar to Mycobacterium leprae TrxA SWALL:Q49716 (EMBL:U00014) (255 aa) fasta scores: E(): 7.3e-18, 37.22% id in 223 aa, and to Streptomyces coelicolor thioredoxin SC8F4.23 TR:Q9L2A3 (EMBL:AL137242) (318 aa) fasta scores: E(): 6.6e-10, 34.06% id in 320 aa, and to Corynebacterium nephridii thioredoxin C-1 SW:THI1_CORNE (P00275) (105 aa) fasta scores: E(): 0.11, 25.96% id in 104 aa; thioredoxin-like protein 1042460..1043356 Corynebacterium diphtheriae NCTC 13129 2650830 NP_939426.1 CDS glgB NC_002935.2 1043761 1045959 R catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching protein complement(1043761..1045959) Corynebacterium diphtheriae NCTC 13129 2649325 NP_939427.1 CDS DIP1066 NC_002935.2 1046014 1048050 R Similar to Mycobacterium smegmatis glucanase GlgE TR:Q9RP48 (EMBL:AF172946) (697 aa) fasta scores: E(): 2.1e-155, 58.52% id in 692 aa, and to Streptomyces coelicolor alpha-amylase Pep1A TR:Q9L1K2 (EMBL:AL138978) (675 aa) fasta scores: E(): 5.1e-126, 50% id in 662 aa, and to Dictyoglomus thermophilum alpha-amylase 3 AmyC SW:AMY3_DICTH (P14899) (498 aa) fasta scores: E(): 0.17, 23.84% id in 453 aa; alpha-amylase complement(1046014..1048050) Corynebacterium diphtheriae NCTC 13129 2649326 NP_939428.1 CDS DIP1067 NC_002935.2 1048145 1049014 D Similar to Mycobacterium tuberculosis ABC transporter ATP-binding protein Rv3041c or MTV012.56c TR:O53288 (EMBL:AL021287) (287 aa) fasta scores: E(): 3.2e-63, 62.95% id in 278 aa, and to Streptomyces coelicolor ABC transporter ATP-binding subunit SCI5.06c TR:Q9X9Z4 (EMBL:AL079332) (265 aa) fasta scores: E(): 1e-41, 49.41% id in 257 aa; ABC transporter ATP-binding protein 1048145..1049014 Corynebacterium diphtheriae NCTC 13129 2649327 NP_939429.1 CDS DIP1068 NC_002935.2 1049093 1049902 D Similar to Mycobacterium tuberculosis hypothetical 31.5 kDa protein Rv3040c or MTV012.55c TR:O53287 (EMBL:AL021287) (288 aa) fasta scores: E(): 4.1e-25, 37.2% id in 258 aa, and to uncultured proteobacterium EBAC31A08 predicted MutT superfamily hydrolase TR:Q9F7R7 (EMBL:AF279106) (264 aa) fasta scores: E(): 8.4e-18, 31.79% id in 239 aa; NUDIX/MutT family hydrolase 1049093..1049902 Corynebacterium diphtheriae NCTC 13129 2649328 NP_939430.1 CDS DIP1069 NC_002935.2 1049947 1051131 D Similar to Mycobacterium tuberculosis hypothetical 39.1 kDa protein Rv3037c or MTV012.52C TR:O53284 (EMBL:AL021287) (358 aa) fasta scores: E(): 3.1e-43, 42.49% id in 353 aa, and to Streptomyces coelicolor Sc6g4.36C protein sc6g4.36C TR:O86799 (EMBL:AL031317) (426 aa) fasta scores: E(): 2.5e-18, 31.36% id in 322 aa; hypothetical protein 1049947..1051131 Corynebacterium diphtheriae NCTC 13129 2649329 NP_939431.1 CDS etfB NC_002935.2 1051307 1052101 D Similar to Mycobacterium tuberculosis electron transfer flavoprotein beta-subunit FixA or Rv3029c or MT3113 or MTV012.44c SW:ETFB_MYCTU (O53276) (266 aa) fasta scores: E(): 8.4e-45, 51.31% id in 267 aa; electron transfer flavoprotein subunit beta 1051307..1052101 Corynebacterium diphtheriae NCTC 13129 2649330 NP_939432.1 CDS etfA NC_002935.2 1052119 1053072 D Similar to Mycobacterium tuberculosis electron transfer flavoprotein alpha-subunit EtfA or FixB or Rv3028c or MT3112 or MTV012.43c SW:ETFA_MYCTU (O53275) (318 aa) fasta scores: E(): 1.8e-48, 51.1% id in 317 aa; electron transfer flavoprotein subunit alpha 1052119..1053072 Corynebacterium diphtheriae NCTC 13129 2649331 NP_939433.1 CDS DIP1072 NC_002935.2 1053532 1054668 D Similar to Mycobacterium tuberculosis CDC1551 aminotransferase, class V MT3109 TR:AAK47439 (EMBL:AE007129) (393 aa) fasta scores: E(): 1.1e-52, 45.71% id in 385 aa, and to Mycobacterium tuberculosis NifS-like protein Rv3025c or MTV012.40C TR:O53272 (EMBL:AL021287) (393 aa) fasta scores: E(): 1.1e-52, 45.71% id in 385 aa, and to Ruminococcus flavefaciens cysteine desulfurase IscS or NifS SW:ISCS_RUMFL (O54055) (396 aa) fasta scores: E(): 2.1e-40, 36.48% id in 381 aa; class V aminotransferase 1053532..1054668 Corynebacterium diphtheriae NCTC 13129 2649332 NP_939434.1 CDS DIP1073 NC_002935.2 1054665 1055513 R Similar to Streptomyces coelicolor hypothetical 30.6 kDa protein 2scc13.11C TR:Q9F3H8 (EMBL:AL442165) (289 aa) fasta scores: E(): 5.6e-28, 36.2% id in 279 aa, and to Neisseria meningitidis (serogroup A), and transferase nma1087 or nmb0869 TR:Q9JQL8 (EMBL:AL162755) (263 aa) fasta scores: E(): 1.6e-09, 26.42% id in 246 aa, and to Escherichia coli spermidine synthase spee or B0121 SW:SPEE_ECOLI (P09158) (287 aa) fasta scores: E(): 0.0013, 28.28% id in 152 aa; transferase complement(1054665..1055513) Corynebacterium diphtheriae NCTC 13129 2649333 NP_939435.1 CDS mnmA NC_002935.2 1055670 1056770 D catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 1055670..1056770 Corynebacterium diphtheriae NCTC 13129 2649334 NP_939436.1 CDS DIP1075 NC_002935.2 1056799 1057866 D Similar to Mycobacterium leprae hypothetical protein ML1706 TR:Q9CBR6 (EMBL:AL583923) (337 aa) fasta scores: E(): 4.5e-19, 32.26% id in 313 aa, and to Mycobacterium tuberculosis CDC1551 vitamin-b12 independent methionine synthase MT3095 TR:AAK47424 (EMBL:AE007129) (337 aa) fasta scores: E(): 1.4e-18, 31.94% id in 313 aa, and to Mycobacterium tuberculosis hypothetical 34.2 kDa protein Rv3015c or MTV012.29C TR:O53262 (EMBL:AL021287) (337 aa) fasta scores: E(): 1.4e-18, 31.94% id in 313 aa; hypothetical protein 1056799..1057866 Corynebacterium diphtheriae NCTC 13129 2649335 NP_939437.1 CDS DIP1076 NC_002935.2 1057910 1058614 R 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon complement(1057910..1058614) Corynebacterium diphtheriae NCTC 13129 2649336 NP_939438.1 CDS ligA NC_002935.2 1058711 1060744 D this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 1058711..1060744 Corynebacterium diphtheriae NCTC 13129 2649337 NP_939439.1 CDS DIP1078 NC_002935.2 1060807 1061469 R Similar to Mycobacterium tuberculosis hypothetical 23.0 kDa protein Rv3013 or MTV012.27 TR:O53260 (EMBL:AL021287) (218 aa) fasta scores: E(): 2.6e-27, 40.63% id in 219 aa, and to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT3093 TR:AAK47422 (EMBL:AE007128) (240 aa) fasta scores: E(): 2.8e-27, 40.63% id in 219 aa, and to Mycobacterium leprae hypothetical 24.4 kDa protein MLCB637.11c TR:O33103 (EMBL:Z99263) (230 aa) fasta scores: E(): 1.3e-26, 40.18% id in 219 aa, and to Mycobacterium leprae hypothetical protein ML1704 TR:Q9CBR7 (EMBL:AL583923) (232 aa) fasta scores: E(): 1.3e-26, 40.18% id in 219 aa; hypothetical protein complement(1060807..1061469) Corynebacterium diphtheriae NCTC 13129 2649338 NP_939440.1 CDS gatC NC_002935.2 1061719 1062018 D allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C 1061719..1062018 Corynebacterium diphtheriae NCTC 13129 2649339 NP_939441.1 CDS gatA NC_002935.2 1062018 1063502 D allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A 1062018..1063502 Corynebacterium diphtheriae NCTC 13129 2649340 NP_939442.1 CDS DIP1081 NC_002935.2 1063604 1064095 R Similar to Bacillus halodurans ribosomal-protein (S18)-alanine acetyltransferase BH0547 TR:Q9KFD4 (EMBL:AP001508) (151 aa) fasta scores: E(): 0.0026, 52.83% id in 53 aa, and to Homo sapiens similar to spermidine/spermine N1-acetyl transferase TR:AAH11751 (EMBL:BC011751) (170 aa) fasta scores: E(): 0.0061, 28.85% id in 149 aa; acetyltransferase complement(1063604..1064095) Corynebacterium diphtheriae NCTC 13129 2649341 NP_939443.1 CDS DIP1082 NC_002935.2 1064159 1065574 D Similar to Mycobacterium tuberculosis CDC1551 drug transporter MT1289 TR:AAK45547 (EMBL:AE007004) (579 aa) fasta scores: E(): 9.3e-70, 43.87% id in 449 aa, and to Streptomyces coelicolor transmembrane efflux protein SCD82.12 TR:Q9L0L9 (EMBL:AL160431) (490 aa) fasta scores: E(): 5.7e-43, 31.79% id in 456 aa, and to Streptomyces glaucescens tetracenomycin C resistance and export protein TcmA SW:TCMA_STRGA (P39886) (538 aa) fasta scores: E(): 3.5e-39, 31.29% id in 425 aa; major facilitator family transmembrane efflux protein 1064159..1065574 Corynebacterium diphtheriae NCTC 13129 2649342 NP_939444.1 CDS DIP1083 NC_002935.2 1065633 1065968 R Similar to Streptomyces coelicolor membrane protein SCE6.24 TR:Q9KZR4 (EMBL:AL353832) (100 aa) fasta scores: E(): 4.1e-13, 49.47% id in 95 aa; hypothetical protein complement(1065633..1065968) Corynebacterium diphtheriae NCTC 13129 2649343 NP_939445.1 CDS DIP1084 NC_002935.2 1066370 1067410 D Similar to Streptomyces coelicolor FecCD-family membrane transport protein SC2H12.15 TR:Q9K469 (EMBL:AL359215) (368 aa) fasta scores: E(): 2.3e-50, 48.1% id in 343 aa, and to Yersinia pestis hemin transport system permease HmuU YPO0280 SW:HMUU_YERPE (Q56992) (334 aa) fasta scores: E(): 6.8e-30, 36.33% id in 344 aa; iron ABC transporter membrane protein 1066370..1067410 Corynebacterium diphtheriae NCTC 13129 2649344 NP_939446.1 CDS DIP1085 NC_002935.2 1067410 1068207 D Similar to Bacillus subtilis ferrichrome transport ATP-binding protein FhuC SW:FHUC_BACSU (P49938) (269 aa) fasta scores: E(): 5.1e-24, 35.15% id in 256 aa, and to Escherichia coli iron(III)dicitrate transport ATP-binding protein FecE or B4287 SW:FECE_ECOLI (P15031) (255 aa) fasta scores: E(): 5.5e-24, 37.86% id in 243 aa; iron ABC transporter ATP-binding protein 1067410..1068207 Corynebacterium diphtheriae NCTC 13129 2649345 NP_939447.1 CDS DIP1086 NC_002935.2 1068219 1069283 D Similar to Streptomyces coelicolor iron transport lipoprotein SC2H12.17 TR:Q9K467 (EMBL:AL359215) (345 aa) fasta scores: E(): 8.3e-30, 36.76% id in 321 aa, and to Yersinia pestis hemin-binding periplasmic protein HmuT precursor YPO0281 SW:HMUT_YERPE (Q56991) (279 aa) fasta scores: E(): 0.022, 22.69% id in 282 aa; iron transport system exported solute-binding component 1068219..1069283 Corynebacterium diphtheriae NCTC 13129 2649346 NP_939448.1 CDS DIP1087 NC_002935.2 1069391 1070098 D hypothetical protein 1069391..1070098 Corynebacterium diphtheriae NCTC 13129 2649347 NP_939449.1 CDS pfkA NC_002935.2 1070298 1071326 D catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 1070298..1071326 Corynebacterium diphtheriae NCTC 13129 2649348 NP_939450.1 CDS gatB NC_002935.2 1071435 1072940 D allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B 1071435..1072940 Corynebacterium diphtheriae NCTC 13129 2650831 NP_939451.1 CDS DIP1090 NC_002935.2 1073046 1074143 D Similar to Escherichia coli ORF_O346 B3001 TR:Q46851 (EMBL:U28377) (346 aa) fasta scores: E(): 2.5e-73, 56.21% id in 354 aa, to Streptomyces coelicolor oxidoreductase SC7H9.06 TR:Q9EWJ0 (EMBL:AL450223) (348 aa) fasta scores: E(): 1.6e-65, 58.48% id in 342 aa, and to Homo sapiens voltage-gated potassium channel beta-2 subunit KcnAB2 or KcnA2B or KcnK2 TR:Q13303 (EMBL:U33429) (367 aa) fasta scores: E(): 9.5e-27, 34.74% id in 331 aa; aldo/keto reductase 1073046..1074143 Corynebacterium diphtheriae NCTC 13129 2650832 NP_939452.1 CDS lysE NC_002935.2 1074172 1074858 R Similar to Corynebacterium glutamicum lysine exporter protein LysE SW:LYSE_CORGL (P94633) (233 aa) fasta scores: E(): 3.8e-40, 45.02% id in 231 aa, and to Escherichia coli hypothetical protein YggA or B2923 SW:YGGA_ECOLI (P11667) (211 aa) fasta scores: E(): 3.1e-09, 32.44% id in 225 aa; lysine exporter protein complement(1074172..1074858) Corynebacterium diphtheriae NCTC 13129 2650833 NP_939453.1 CDS lysG NC_002935.2 1074929 1075810 D specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport; chromosome replication initiation inhibitor protein 1074929..1075810 Corynebacterium diphtheriae NCTC 13129 2650834 NP_939454.1 CDS DIP1093 NC_002935.2 1075821 1076903 R Similar to Streptomyces lividans and S. coelicolor hypothetical 38.1 kDa protein 3SCF60.09 TR:O85700 (EMBL:AF072709) (341 aa) fasta scores: E(): 4.8e-70, 54.38% id in 331 aa, and to Rhodobacter sphaeroides hypothetical 38.5 kDa protein ORF11 TR:O33560 (EMBL:AJ000977) (333 aa) fasta scores: E(): 5.6e-48, 45.28% id in 318 aa; hypothetical protein complement(1075821..1076903) Corynebacterium diphtheriae NCTC 13129 2650835 NP_939455.1 CDS DIP1094 NC_002935.2 1076975 1077727 D Similar to Mycobacterium tuberculosis hypothetical 25.9 kDa protein Rv2972c or MTCY349.15 TR:P95123 (EMBL:Z83018) (237 aa) fasta scores: E(): 3.4e-25, 36.55% id in 238 aa, and to Streptomyces coelicolor lipoprotein SCE41.16c TR:Q9F2P3 (EMBL:AL442120) (258 aa) fasta scores: E(): 1.5e-19, 37.86% id in 169 aa. Note: Contains a twin-arginine translocation (TAT) system recognition motif (RRSFIRK) at the N-terminal region; hypothetical protein 1076975..1077727 Corynebacterium diphtheriae NCTC 13129 2650836 NP_939456.1 CDS DIP1095 NC_002935.2 1077807 1078934 D Similar to Mycobacterium leprae hypothetical 29.5 kDa protein ML1698 or MLCB637.18 TR:O33110 (EMBL:Z99263) (277 aa) fasta scores: E(): 6.4e-10, 30.79% id in 276 aa, and to Mycobacterium tuberculosis hypothetical 28.9 kDa protein Rv3005c or MTV012.19c TR:O53252 (EMBL:AL021287) (279 aa) fasta scores: E(): 1.3e-08, 28.15% id in 277 aa; hypothetical protein 1077807..1078934 Corynebacterium diphtheriae NCTC 13129 2650837 NP_939457.1 CDS ilvD NC_002935.2 1079011 1080852 R catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase complement(1079011..1080852) Corynebacterium diphtheriae NCTC 13129 2650838 NP_939458.1 CDS DIP1097 NC_002935.2 1081141 1081626 R Similar to Mycobacterium tuberculosis low molecular weight protein antigen 6 Cfp6 or Rv3004 or MT3084.1 or MTV012.18 SW:CFP6_MYCTU (O53251) (112 aa) fasta scores: E(): 7.9e-07, 34.57% id in 107 aa; low molecular weight protein antigen 6 complement(1081141..1081626) Corynebacterium diphtheriae NCTC 13129 2650839 NP_939459.1 CDS ilvB NC_002935.2 1082013 1083971 D acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate; acetolactate synthase 1 catalytic subunit 1082013..1083971 Corynebacterium diphtheriae NCTC 13129 2650840 NP_939460.1 CDS ilvH NC_002935.2 1083987 1084511 D with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 1083987..1084511 Corynebacterium diphtheriae NCTC 13129 2650841 NP_939461.1 CDS ilvC NC_002935.2 1084631 1085644 D catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 1084631..1085644 Corynebacterium diphtheriae NCTC 13129 2650842 NP_939462.1 CDS DIP1101 NC_002935.2 1085794 1086717 D Similar to Staphylococcus aureus (strain N315) CzrB protein or SA1948 or SAV2146 TR:BAB58308 (EMBL:AP003136) (325 aa) fasta scores: E(): 4e-37, 37.74% id in 302 aa, and to Alcaligenes eutrophus cobalt-zinc-cadmium resistance protein CzcD SW:CZCD_ALCEU (P13512) (316 aa) fasta scores: E(): 9.2e-36, 40.84% id in 284 aa; cation-efflux system integral membrane protein 1085794..1086717 Corynebacterium diphtheriae NCTC 13129 2650843 NP_939463.1 CDS DIP1102 NC_002935.2 1086770 1088578 D Similar to Anabaena sp All3615 protein TR:BAB75314 (EMBL:AP003593) (621 aa) fasta scores: E(): 1.8e-37, 29.29% id in 594 aa, and to Streptomyces coelicolor hypothetical 67.8 kDa protein SC4G2.12c TR:O86684 (EMBL:AL031371) (605 aa) fasta scores: E(): 9.5e-29, 34.55% id in 602 aa; hypothetical protein 1086770..1088578 Corynebacterium diphtheriae NCTC 13129 2650844 NP_939464.1 CDS DIP1103 NC_002935.2 1088634 1090115 D hypothetical protein 1088634..1090115 Corynebacterium diphtheriae NCTC 13129 2650845 NP_939465.1 CDS serA NC_002935.2 1090278 1091873 D catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 1090278..1091873 Corynebacterium diphtheriae NCTC 13129 2650846 NP_939466.1 CDS leuB NC_002935.2 1092016 1093035 D catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 1092016..1093035 Corynebacterium diphtheriae NCTC 13129 2650847 NP_939467.1 CDS DIP1110 NC_002935.2 1094680 1094859 D Some similarity to Vibrio cholerae DNA polymerase III, epsilon subunit, VC1290 TR:Q9KSG6 (EMBL:AE004208) (236 aa) fasta scores: E(): 0.37, 38.33% id in 60 aa; hypothetical protein 1094680..1094859 Corynebacterium diphtheriae NCTC 13129 2650849 NP_939468.1 CDS DIP1111 NC_002935.2 1094905 1095237 D no significant database matches; hypothetical protein 1094905..1095237 Corynebacterium diphtheriae NCTC 13129 2650850 NP_939469.1 CDS DIP1112 NC_002935.2 1095311 1096108 D Similar to Mycobacterium tuberculosis possible 2-hydroxyhepta-2,4-diene- 1,7-dioate isomerase Rv2993c or MTV012.07c TR:O53242 (EMBL:AL021287) (239 aa) fasta scores: E(): 2.5e-42, 48.73% id in 238 aa; FAA family hydrolase 1095311..1096108 Corynebacterium diphtheriae NCTC 13129 2650851 NP_939470.1 CDS DIP1113 NC_002935.2 1096131 1096775 D Similar to Streptomyces coelicolor methyltransferase SCF43A.25c TR:Q9XA90 (EMBL:AL096837) (215 aa) fasta scores: E(): 2.2e-12, 36.23% id in 207 aa; hypothetical protein 1096131..1096775 Corynebacterium diphtheriae NCTC 13129 2650852 NP_939471.1 CDS DIP1114 NC_002935.2 1096756 1097889 R synthesizes isochorismate acid from chorismate; isochorismate synthase complement(1096756..1097889) Corynebacterium diphtheriae NCTC 13129 2650853 NP_939472.1 CDS gltX NC_002935.2 1097919 1099412 D Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 1097919..1099412 Corynebacterium diphtheriae NCTC 13129 2650854 NP_939473.1 CDS DIP1116 NC_002935.2 1099572 1100606 D Similar to Mycobacterium tuberculosis CDC1551 esterase, MT3397 TR:AAK47740 (EMBL:AE007148) (304 aa) fasta scores: E(): 5.3e-09, 30.57% id in 242 aa, and to Piromyces equi cinnamoyl ester hydrolase EstA TR:Q9Y871 (EMBL:AF164516) (536 aa) fasta scores: E(): 1.2e-06, 25.19% id in 258 aa, and to Pseudomonas fluorescens esterase D XynD TR:Q51815 (EMBL:X58956) (583 aa) fasta scores: E(): 5.8e-06, 27.37% id in 274 aa; exported esterase/hydrolase 1099572..1100606 Corynebacterium diphtheriae NCTC 13129 2650855 NP_939474.1 CDS DIP1117 NC_002935.2 1100963 1101508 R Similar to Streptomyces coelicolor SC10A5.11 protein TR:O54102 (EMBL:AL021529) (198 aa) fasta scores: E(): 8.8e-14, 32.94% id in 170 aa, and to Streptomyces roseosporus WhiR protein TR:P72569 (EMBL:U58281) (179 aa) fasta scores: E(): 1.5e-05, 24.5% id in 151 aa; TetR family transcriptional regulator complement(1100963..1101508) Corynebacterium diphtheriae NCTC 13129 2650858 NP_939475.1 CDS DIP1118 NC_002935.2 1101650 1103803 D Similar to Streptomyces coelicolor membrane protein SC10A5.10c SW:MMLB_STRCO (O54101) (847 aa) fasta scores: E(): 5.3e-106, 47.61% id in 733 aa, and to Mycobacterium tuberculosis membrane protein MmpL8 or Rv3823c or MT3931 or MTCY409.07 SW:MML8_MYCTU (O07800) (1089 aa) fasta scores: E(): 1.1e-21, 27.76% id in 461 aa; MmpL family integral membrane protein 1101650..1103803 Corynebacterium diphtheriae NCTC 13129 2650859 NP_939476.1 CDS DIP1119 NC_002935.2 1103979 1105439 D Similar to Mycobacterium leprae hypothetical protein ML0099 TR:Q9CDB3 (EMBL:AL583917) (336 aa) fasta scores: E(): 7e-07, 27.58% id in 261 aa, and to Mycobacterium tuberculosis hypothetical 35.4 kDa protein Rv3802c or MTV026.07c TR:O53581 (EMBL:AL022076) (336 aa) fasta scores: E(): 4.2e-06, 27.98% id in 243 aa; hypothetical protein 1103979..1105439 Corynebacterium diphtheriae NCTC 13129 2649920 NP_939477.1 CDS DIP1120 NC_002935.2 1105526 1105807 D hypothetical protein 1105526..1105807 Corynebacterium diphtheriae NCTC 13129 2649921 NP_939478.1 CDS DIP1121 NC_002935.2 1105862 1105996 D Doubtful CDS. No significant database matches; hypothetical protein 1105862..1105996 Corynebacterium diphtheriae NCTC 13129 2649922 NP_939479.1 CDS ppc NC_002935.2 1106381 1109089 D catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 1106381..1109089 Corynebacterium diphtheriae NCTC 13129 2649924 NP_939480.1 CDS DIP1123 NC_002935.2 1109099 1109488 R Similar to Streptomyces verticillus PhnA-like protein TR:Q9FB32 (EMBL:AF210249) (117 aa) fasta scores: E(): 3.3e-20, 56.19% id in 121 aa, and to Escherichia coli PhnA protein or B4108 or Z5710 or ECS5090 SW:PHNA_ECOLI (P16680) (111 aa) fasta scores: E(): 7.1e-17, 51.28% id in 117 aa; hypothetical protein complement(1109099..1109488) Corynebacterium diphtheriae NCTC 13129 2649925 NP_939481.1 CDS DIP1124 NC_002935.2 1109532 1110524 R Similar to Bacillus subtilis biotin synthase BioB SW:BIOB_BACSU (P53557) (335 aa) fasta scores: E(): 1.4e-38, 38.19% id in 322 aa, and to Corynebacterium glutamicum biotin synthase BioB SW:BIOB_CORGL (P46396) (334 aa) fasta scores: E(): 3.1e-31, 35.78% id in 299 aa; biotin synthase complement(1109532..1110524) Corynebacterium diphtheriae NCTC 13129 2649926 NP_939482.1 CDS DIP1125 NC_002935.2 1110605 1111162 D Similar to Synechocystis sp. hypothetical 21.9 kDa protein SLL1660 SWALL:P72810 (EMBL:D90901) (194 aa) fasta scores: E(): 2.9e-16, 33.13% id in 166 aa, and to Pseudomonas denitrificans hypothetical 19.2 kDa protein in cobO 3'region SWALL:YCB8_PSEDE (SWALL:P29941) (175 aa) fasta scores: E(): 6.6e-07, 34.24% id in 146 aa; hypothetical protein 1110605..1111162 Corynebacterium diphtheriae NCTC 13129 2649927 NP_939483.1 CDS DIP1126 NC_002935.2 1111173 1111898 R Similar to Mycobacterium tuberculosis probable transcriptional regulator Rv2989 or MT3067 or MTV012.03 SWALL:AAK47396 (EMBL:AL021287) (267 aa) fasta scores: E(): 8.6e-39, 48.26% id in 230 aa, and to Streptomyces coelicolor transcriptional regulator SC1C2.33c SWALL:O86533 (EMBL:AL031124) (238 aa) fasta scores: E(): 7.2e-31, 42.24% id in 232 aa; IclR family transcriptional regulator complement(1111173..1111898) Corynebacterium diphtheriae NCTC 13129 2649928 NP_939484.1 CDS leuC NC_002935.2 1111988 1113430 D dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 1111988..1113430 Corynebacterium diphtheriae NCTC 13129 2649929 NP_939485.1 CDS leuD NC_002935.2 1113442 1114032 D catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 1113442..1114032 Corynebacterium diphtheriae NCTC 13129 2649930 NP_939486.1 CDS DIP1129 NC_002935.2 1114111 1115121 R Similar to Mycobacterium leprae hypothetical protein ML1682 SWALL:Q9CBR8 (EMBL:AL583923) (311 aa) fasta scores: E(): 1.4e-40, 42.66% id in 300 aa, and N-terminal region to Streptomyces coelicolor MutT-like protein SCD84.10c SWALL:Q9KZV8 (EMBL:AL353816) (142 aa) fasta scores: E(): 4.4e-13, 42.4% id in 125 aa; hypothetical protein complement(1114111..1115121) Corynebacterium diphtheriae NCTC 13129 2649931 NP_939487.1 CDS gpsA NC_002935.2 1115316 1116311 D catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 1115316..1116311 Corynebacterium diphtheriae NCTC 13129 2649932 NP_939488.1 CDS ddl NC_002935.2 1116334 1117431 D D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 1116334..1117431 Corynebacterium diphtheriae NCTC 13129 2649933 NP_939489.1 CDS DIP1132 NC_002935.2 1117438 1118376 R Similar to Mycobacterium leprae possible secreted protein ML1677 TR:Q9CBS1 (EMBL:AL583923) (191 aa) fasta scores: E(): 8.9e-13, 32.447% id in 188 aa, and to Mycobacterium tuberculosis hypothetical 18.8 kDa protein Rv2980 or MTCY349.07c TR:P95115 (EMBL:Z83018) (181 aa) fasta scores: E(): 1.5e-09, 31.098% id in 164 aa; hypothetical protein complement(1117438..1118376) Corynebacterium diphtheriae NCTC 13129 2649934 NP_939490.1 CDS thiL NC_002935.2 1118468 1119457 D catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase 1118468..1119457 Corynebacterium diphtheriae NCTC 13129 2649935 NP_939491.1 CDS ung NC_002935.2 1119460 1120128 D Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 1119460..1120128 Corynebacterium diphtheriae NCTC 13129 2649936 NP_939492.1 CDS DIP1135 NC_002935.2 1120294 1121799 D Similar to Mycobacterium tuberculosis hypothetical 46.7 kDa protein Rv2974c or MTCY349.13 TR:P95121 (EMBL:Z83018) (470 aa) fasta scores: E(): 4e-28, 33.402% id in 485 aa, and to Clostridium acetobutylicum predicted kinase related to hydroxyacetone kinase YloV ortholog CAC1735 TR:AAK79701 (EMBL:AE007682) (547 aa) fasta scores: E(): 3.8e-21, 25.690% id in 471 aa; kinase 1120294..1121799 Corynebacterium diphtheriae NCTC 13129 2649937 NP_939493.1 CDS recG NC_002935.2 1121804 1123918 D Similar to Bacillus subtilis ATP-dependent DNA helicase RecG SW:RECG_BACSU (O34942) (682 aa) fasta scores: E(): 3.3e-69, 33.862% id in 694 aa, and to Escherichia coli ATP-dependent DNA helicase RecG or B3652 SW:RECG_ECOLI (P24230) (693 aa) fasta scores: E(): 8.9e-63, 34.765% id in 722 aa; ATP-dependent DNA helicase 1121804..1123918 Corynebacterium diphtheriae NCTC 13129 2649938 NP_939494.1 CDS DIP1137 NC_002935.2 1123946 1124167 D Similar to C-terminus of Mycobacterium smegmatis pyruvate carboxylase Pyc TR:Q9F843 (EMBL:AF262949) (1127 aa) fasta scores: E(): 1.9e-05, 47.761% id in 67 aa, to Bacillus subtilis YngXX TR:Q9R9I3 (EMBL:AF184956) (73 aa) fasta scores: E(): 0.0043, 36.765% id in 68 aa, and to Propionibacterium freudenreichii shermanii biotin carboxyl carrier protein of methylmalonyl-CoA carboxyl- transferase SW:BCCP_PROFR (P02904) (123 aa) fasta scores: E(): 0.0079, 38.806% id in 67 aa; biotin carboxyl carrier protein 1123946..1124167 Corynebacterium diphtheriae NCTC 13129 2649939 NP_939495.1 CDS DIP1138 NC_002935.2 1124164 1124742 D Similar to Mycobacterium tuberculosis hypothetical 19.8 kDa protein Rv2966c or MTCY349.21 TR:P95128 (EMBL:Z83018) (188 aa) fasta scores: E(): 2.6e-22, 42.703% id in 185 aa, and to Streptomyces coelicolor methylase SC7A1.11 TR:Q9ZBR2 (EMBL:AL034447) (195 aa) fasta scores: E(): 1.2e-21, 44.505% id in 182 aa; DNA methylase 1124164..1124742 Corynebacterium diphtheriae NCTC 13129 2649940 NP_939496.1 CDS coaD NC_002935.2 1124750 1125229 D Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 1124750..1125229 Corynebacterium diphtheriae NCTC 13129 2649941 NP_939497.1 CDS DIP1140 NC_002935.2 1125316 1125474 D hypothetical protein 1125316..1125474 Corynebacterium diphtheriae NCTC 13129 2649942 NP_939498.1 CDS DIP1141 NC_002935.2 1125604 1125777 D hypothetical protein 1125604..1125777 Corynebacterium diphtheriae NCTC 13129 2649943 NP_939499.1 CDS atrC NC_002935.2 1125798 1126565 R Similar to Streptomyces coelicolor ATP-binding protein AtrC SWALL:Q9F3K7 (EMBL:AL391763) (253 aa) fasta scores: E(): 5.1e-58, 68% id in 250 aa, and to Rhizobium sp TAL1145 MidC SWALL:Q9EYT0 (EMBL:AF312768) (265 aa) fasta scores: E(): 1.9e-52, 60.78% id in 255 aa; ABC transporter ATP-binding protein complement(1125798..1126565) Corynebacterium diphtheriae NCTC 13129 2649944 NP_939500.1 CDS DIP1143 NC_002935.2 1126569 1127513 R Similar to Streptomyces coelicolor permease AtrB SWALL:Q9F3K6 (EMBL:AL391763) (316 aa) fasta scores: E(): 7.1e-49, 50.72% id in 276 aa, and to Rhizobium meliloti amino acid uptake ABC transporter permease RB0674 or SMB21095 SWALL:CAC49074 (EMBL:AL603644) (290 aa) fasta scores: E(): 3.5e-37, 42.96% id in 263 aa; ABC transporter complement(1126569..1127513) Corynebacterium diphtheriae NCTC 13129 2648807 NP_939501.1 CDS DIP1144 NC_002935.2 1127571 1128464 R Similar to Rhizobium spTAL1145 MidA SWALL:Q9EYT2 (EMBL:AF312768) (281 aa) fasta scores: E(): 4.6e-18, 30.36% id in 247 aa, and to Escherichia coli glutamine-binding periplasmic protein precursor GlnH or B0811 or Z1033 or ECS0889 SWALL:GLNH_ECOLI (SWALL:P10344) (248 aa) fasta scores: E(): 1.1e-13, 30.55% id in 252 aa; hypothetical protein complement(1127571..1128464) Corynebacterium diphtheriae NCTC 13129 2648808 NP_939502.1 CDS DIP1145 NC_002935.2 1128534 1129466 R Similar to Vibrio cholerae hypothetical protein VCA0040 SWALL:Q9KNC5 (EMBL:AE004347) (308 aa) fasta scores: E(): 3.4e-22, 31.48% id in 270 aa, and to Methanothermobacter thermautotrophicus hypothetical 35.5 kDa protein MTH465 SWALL:O26565 (EMBL:AE000831) (319 aa) fasta scores: E(): 2.9e-18, 31.12% id in 241 aa; hypothetical protein complement(1128534..1129466) Corynebacterium diphtheriae NCTC 13129 2648809 NP_939503.1 CDS polA NC_002935.2 1129828 1132527 D has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 1129828..1132527 Corynebacterium diphtheriae NCTC 13129 2648811 NP_939504.1 CDS DIP1147 NC_002935.2 1132577 1133344 R Similar to Streptomyces coelicolor hypothetical 24.3 kDa protein SC7H2.13 SWALL:Q9S2K4 (EMBL:AL109732) (220 aa) fasta scores: E(): 1.4e-39, 50% id in 216 aa, and to Bacillus halodurans BH0355 protein SWALL:Q9KFW5 (EMBL:AP001508) (246 aa) fasta scores: E(): 1.3e-10, 28.51% id in 242 aa; hypothetical protein complement(1132577..1133344) Corynebacterium diphtheriae NCTC 13129 2648812 NP_939505.1 CDS rpsA NC_002935.2 1133555 1135015 D in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 1133555..1135015 Corynebacterium diphtheriae NCTC 13129 2648813 NP_939506.1 CDS DIP1149 NC_002935.2 1135099 1136511 R Similar to Pasteurella multocida hypothetical protein PM0933 SWALL:Q9CMA1 (EMBL:AE006132) (462 aa) fasta scores: E(): 9.1e-43, 32.62% id in 469 aa, and to Escherichia coli anaerobic C4-dicarboxylate transporter DcuC or B0621 or Z0766 or ECS0660 SWALL:DCUC_ECOLI (SWALL:Q47134) (461 aa) fasta scores: E(): 9.6e-19, 31.76% id in 466 aa; transporter complement(1135099..1136511) Corynebacterium diphtheriae NCTC 13129 2648814 NP_939507.1 CDS DIP1150 NC_002935.2 1136731 1137558 R Similar to Bacillus subtilis transcription antiterminator LicT or N15A SWALL:LICT_BACSU (SWALL:P39805) (277 aa) fasta scores: E(): 2.6e-20, 28.72% id in 275 aa, and to Escherichia coli cryptic beta-glucoside Bgl operon antiterminator BglG or BglC or B3723 SWALL:BGLG_ECOLI (SWALL:P11989) (278 aa) fasta scores: E(): 1.4e-18, 27.33% id in 278 aa; transcription antiterminator complement(1136731..1137558) Corynebacterium diphtheriae NCTC 13129 2648815 NP_939508.1 CDS ptsG NC_002935.2 1137670 1139700 R Similar to Corynebacterium glutamicum PTS system, glucose-specific IIABC component PtsG SWALL:PTGA_CORGL (SWALL:Q45298) (674 aa) fasta scores: E(): 2.8e-59, 44.91% id in 688 aa, and to Staphylococcus xylosus PTS system, sucrose-specific IIBC component ScrA SWALL:PTSB_STAXY (SWALL:P51184) (480 aa) fasta scores: E(): 8e-26, 27.73% id in 494 aa; PTS system glucose-specific transporter subunit IIABC complement(1137670..1139700) Corynebacterium diphtheriae NCTC 13129 2648816 NP_939509.1 CDS coaE NC_002935.2 1140082 1140684 D Similar to Corynebacterium glutamicum dephospho-CoA kinase CoaE SWALL:COAE_CORGL (SWALL:P56187) (195 aa) fasta scores: E(): 7.6e-25, 50.81% id in 185 aa, and to Escherichia coli dephospho-CoA kinase CoaE or B0103 or Z0113 or ECS0107 SWALL:COAE_ECOLI (SWALL:P36679) (206 aa) fasta scores: E(): 2.4e-15, 38.37% id in 185 aa; dephospho-CoA kinase 1140082..1140684 Corynebacterium diphtheriae NCTC 13129 2648817 NP_939510.1 CDS DIP1153 NC_002935.2 1140904 1142103 D Similar to Archaeoglobus fulgidus coenzyme PQQ synthesis protein AF2413 SWALL:O30258 (EMBL:AE001109) (375 aa) fasta scores: E(): 1.1e-54, 40.79% id in 375 aa, and to Methylobacterium extorquens coenzyme PQQ synthesis protein E PqqE SWALL:PQQE_METEX (SWALL:P71517) (384 aa) fasta scores: E(): 1e-05, 24.67% id in 381 aa; coenzyme PQQ synthesis-like protein 1140904..1142103 Corynebacterium diphtheriae NCTC 13129 2648479 NP_939511.1 CDS uvrB NC_002935.2 1142204 1144249 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 1142204..1144249 Corynebacterium diphtheriae NCTC 13129 2648480 NP_939512.1 CDS DIP1155 NC_002935.2 1144478 1144918 D Similar to Mycobacterium tuberculosis CDC1551 universal stress protein family MT1672 SWALL:AAK45942 (EMBL:AE007031) (146 aa) fasta scores: E(): 1.4e-19, 49.31% id in 146 aa, and to Rhizobium meliloti hypothetical protein RA0598 or SMA1100 SWALL:AAK65256 (EMBL:AE007249) (153 aa) fasta scores: E(): 6.8e-07, 38.37% id in 86 aa; stress-like protein 1144478..1144918 Corynebacterium diphtheriae NCTC 13129 2648481 NP_939513.1 CDS DIP1156 NC_002935.2 1144967 1147279 R Similar to Streptomyces coelicolor helicase SCE59.11c SWALL:Q9L1U3 (EMBL:AL138851) (744 aa) fasta scores: E(): 5.4e-32, 34.77% id in 788 aa, and to Clostridium acetobutylicum superfamily I DNA helicase CAC1026 SWALL:AAK79002 (EMBL:AE007618) (763 aa) fasta scores: E(): 2e-15, 23.98% id in 788 aa; helicase complement(1144967..1147279) Corynebacterium diphtheriae NCTC 13129 2648482 NP_939514.1 CDS DIP1157 NC_002935.2 1147403 1148248 R N-terminal region similar to Streptomyces coelicolor hypothetical 18.8 kDa protein SC9H11.26c SWALL:Q9KYL5 (EMBL:AL356592) (177 aa) fasta scores: E(): 9.8e-11, 35.13% id in 148 aa. Note: Possible colied-coil region at C-terminal domain from residue 242 till the end; hypothetical protein complement(1147403..1148248) Corynebacterium diphtheriae NCTC 13129 2648557 NP_939515.1 CDS DIP1158 NC_002935.2 1148433 1149080 R Similar to Mycobacterium tuberculosis CDC1551 metallo-beta-lactamase superfamily protein MT1673 SWALL:AAK45943 (EMBL:AE007031) (264 aa) fasta scores: E(): 5e-29, 45.58% id in 204 aa, and to Streptomyces coelicolor hydrolase SCC54.20 SWALL:Q9Z505 (EMBL:AL035591) (218 aa) fasta scores: E(): 7.2e-26, 40.55% id in 217 aa; hydrolase complement(1148433..1149080) Corynebacterium diphtheriae NCTC 13129 2648558 NP_939516.1 CDS uvrA NC_002935.2 1149234 1152095 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 1149234..1152095 Corynebacterium diphtheriae NCTC 13129 2648559 NP_939517.1 CDS infC NC_002935.2 1152383 1152886 D IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 1152383..1152886 Corynebacterium diphtheriae NCTC 13129 2648560 NP_939518.1 CDS rpmI NC_002935.2 1152916 1153110 D Similar to Streptomyces coelicolor 50S ribosomal protein L35 RpmI or SCI35.21c SWALL:RL35_STRCO (SWALL:O88059) (64 aa) fasta scores: E(): 1.1e-10, 58.06% id in 62 aa, and to Bacillus subtilis 50S ribosomal protein L35 RpmI SWALL:RL35_BACSU (SWALL:P55874) (65 aa) fasta scores: E(): 1.5e-07, 50% id in 60 aa; 50S ribosomal protein L35 1152916..1153110 Corynebacterium diphtheriae NCTC 13129 2648561 NP_939519.1 CDS rplT NC_002935.2 1153172 1153555 D binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 1153172..1153555 Corynebacterium diphtheriae NCTC 13129 2648562 NP_939520.1 CDS DIP1163 NC_002935.2 1153805 1154350 R hypothetical protein complement(1153805..1154350) Corynebacterium diphtheriae NCTC 13129 2648563 NP_939521.1 CDS tsnR NC_002935.2 1154597 1155415 D Similar to Mycobacterium tuberculosis TsnR or Rv1644 or MT1682 or MTCY06H11.08 SWALL:AAK45951 (EMBL:Z85982) (260 aa) fasta scores: E(): 2.4e-45, 52.85% id in 263 aa, and to Mycobacterium leprae rRNA methyltransferase TsnR or ML1397 SWALL:Q9CC19 (EMBL:AL583921) (259 aa) fasta scores: E(): 6.7e-45, 52.89% id in 259 aa, and to Bacillus halodurans rRNA methylase BH3112 SWALL:Q9K894 (EMBL:AP001517) (251 aa) fasta scores: E(): 3.2e-17, 35.24% id in 244 aa; rRNA methyltransferase 1154597..1155415 Corynebacterium diphtheriae NCTC 13129 2648564 NP_939522.1 CDS pheS NC_002935.2 1155546 1156601 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 1155546..1156601 Corynebacterium diphtheriae NCTC 13129 2648565 NP_939523.1 CDS pheT NC_002935.2 1156643 1159153 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 1156643..1159153 Corynebacterium diphtheriae NCTC 13129 2648566 NP_939524.1 CDS argC NC_002935.2 1159280 1160323 D catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 1159280..1160323 Corynebacterium diphtheriae NCTC 13129 2648567 NP_939525.1 CDS argJ NC_002935.2 1160398 1161558 D bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate; bifunctional ornithine acetyltransferase/N-acetylglutamate synthase 1160398..1161558 Corynebacterium diphtheriae NCTC 13129 2648568 NP_939526.1 CDS argB NC_002935.2 1161595 1162527 D catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 1161595..1162527 Corynebacterium diphtheriae NCTC 13129 2648569 NP_939527.1 CDS argD NC_002935.2 1162520 1163761 D catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine; acetylornithine aminotransferase 1162520..1163761 Corynebacterium diphtheriae NCTC 13129 2649722 NP_939528.1 CDS argF NC_002935.2 1163790 1164749 D catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; ornithine carbamoyltransferase 1163790..1164749 Corynebacterium diphtheriae NCTC 13129 2649723 NP_939529.1 CDS argR NC_002935.2 1164856 1165347 D regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor ArgR 1164856..1165347 Corynebacterium diphtheriae NCTC 13129 2649724 NP_939530.1 CDS argG NC_002935.2 1165505 1166704 D catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming; argininosuccinate synthase 1165505..1166704 Corynebacterium diphtheriae NCTC 13129 2649725 NP_939531.1 CDS argH NC_002935.2 1166704 1168137 D catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 1166704..1168137 Corynebacterium diphtheriae NCTC 13129 2649726 NP_939532.1 CDS DIP1175 NC_002935.2 1168201 1168413 D Similar to Caulobacter crescentus hypothetical protein CC0108 SWALL:Q9ABW2 (EMBL:AE005685) (65 aa) fasta scores: E(): 9.4e-08, 44.64% id in 56 aa, and to Mycobacterium tuberculosis hypothetical 8.3 kDa protein Rv1684 or MTCI125.06 SWALL:O33186 (EMBL:Z98268) (74 aa) fasta scores: E(): 2.1e-07, 57.69% id in 52 aa. Note: Two possible alternative start codons at residues 8 or 11; hypothetical protein 1168201..1168413 Corynebacterium diphtheriae NCTC 13129 2649727 NP_939533.1 CDS tyrS NC_002935.2 1168427 1169689 D catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1168427..1169689 Corynebacterium diphtheriae NCTC 13129 2649728 NP_939534.1 CDS DIP1177 NC_002935.2 1175639 1176715 D C-terminal region similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT1730 SWALL:AAK45999 (EMBL:AE007035) (250 aa) fasta scores: E(): 4e-32, 47.73% id in 243 aa, and to Streptomyces coelicolor hypothetical 22.8 kDa protein SCI51.30c SWALL:Q9S210 (EMBL:AL109848) (210 aa) fasta scores: E(): 3.1e-24, 49.17% id in 181 aa; hypothetical protein 1175639..1176715 Corynebacterium diphtheriae NCTC 13129 2649732 NP_939535.1 CDS DIP1178 NC_002935.2 1176792 1177748 D Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT1731 SWALL:AAK46000 (EMBL:AE007035) (353 aa) fasta scores: E(): 1e-33, 41.06% id in 302 aa, and to Streptomyces coelicolor hypothetical 35.2 kDa protein SCI51.28c SWALL:Q9S212 (EMBL:AL109848) (343 aa) fasta scores: E(): 4e-32, 39.4% id in 302 aa; hypothetical protein 1176792..1177748 Corynebacterium diphtheriae NCTC 13129 2649733 NP_939536.1 CDS DIP1179 NC_002935.2 1177766 1177927 D Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 1177766..1177927 Corynebacterium diphtheriae NCTC 13129 2649734 NP_939537.1 CDS DIP1180 NC_002935.2 1177969 1178790 D Similar to Mycobacterium tuberculosis CDC1551 cytotoxin/hemolysin MT1733 SWALL:AAK46002 (EMBL:AE007035) (268 aa) fasta scores: E(): 2.2e-53, 56.56% id in 274 aa, and to Caulobacter crescentus hemolysin A CC1324 SWALL:Q9A8M9 (EMBL:AE005808) (243 aa) fasta scores: E(): 1.2e-29, 42.27% id in 246 aa; cytotoxin/hemolysin 1177969..1178790 Corynebacterium diphtheriae NCTC 13129 2649735 NP_939538.1 CDS ppnK NC_002935.2 1178790 1179743 D catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 1178790..1179743 Corynebacterium diphtheriae NCTC 13129 2649736 NP_939539.1 CDS recN NC_002935.2 1179859 1181598 D Similar to Mycobacterium tuberculosis DNA repair protein RecN or Rv1696 or MT1735 or MTCI125.18 SWALL:RECN_MYCTU (SWALL:O33197) (587 aa) fasta scores: E(): 1.9e-53, 47.99% id in 598 aa, and to Streptomyces coelicolor DNA repair protein RecN or SCI51.20c SWALL:RECN_STRCO (SWALL:Q9S220) (572 aa) fasta scores: E(): 1.2e-54, 45.64% id in 585 aa, and to Bacillus subtilis DNA repair protein RecN SWALL:RECN_BACSU (SWALL:P17894) (576 aa) fasta scores: E(): 2.5e-38, 32.31% id in 591 aa; DNA repair protein 1179859..1181598 Corynebacterium diphtheriae NCTC 13129 2649737 NP_939540.1 CDS DIP1183 NC_002935.2 1181709 1182902 D Similar to Mycobacterium leprae conserved membrane protein ML1361 SWALL:Q9CC30 (EMBL:AL583921) (393 aa) fasta scores: E(): 7.2e-57, 44.16% id in 394 aa, and to Mycobacterium tuberculosis hypothetical 42.4 kDa protein Rv1697 or MTCI125.19 SWALL:O33198 (EMBL:Z98268) (393 aa) fasta scores: E(): 2.9e-56, 43.4% id in 394 aa; hypothetical protein 1181709..1182902 Corynebacterium diphtheriae NCTC 13129 2649738 NP_939541.1 CDS DIP1184 NC_002935.2 1182927 1183877 D Similar to Mycobacterium tuberculosis hypothetical 32.4 kDa protein Rv1698 precursor or MT1737 or MTCI125.20 SWALL:YG98_MYCTU (SWALL:P58212) (314 aa) fasta scores: E(): 4.4e-22, 31.57% id in 304 aa; hypothetical protein 1182927..1183877 Corynebacterium diphtheriae NCTC 13129 2649739 NP_939542.1 CDS DIP1185 NC_002935.2 1183899 1184537 D Similar to Mycobacterium tuberculosis CDC1551 MutT/NudXx family protein MT1739 SWALL:AAK46008 (EMBL:AE007036) (207 aa) fasta scores: E(): 6.7e-35, 48.3% id in 207 aa, and to Bacillus subtilis ADP-ribose pyrophosphatase NudF SWALL:ADPP_BACSU (SWALL:P54570) (185 aa) fasta scores: E(): 7.9e-15, 35.06% id in 154 aa; hypothetical protein 1183899..1184537 Corynebacterium diphtheriae NCTC 13129 2649740 NP_939543.1 CDS xerD NC_002935.2 1184540 1185475 D site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 1184540..1185475 Corynebacterium diphtheriae NCTC 13129 2649741 NP_939544.1 CDS DIP1187 NC_002935.2 1185667 1186536 D Similar to Mycobacterium leprae possible regulatory protein ML1367 SWALL:Q9CC29 (EMBL:AL583921) (287 aa) fasta scores: E(): 1.8e-76, 72.72% id in 275 aa, and to Bacillus subtilis sporulation initiation inhibitor protein Soj SWALL:SOJ_BACSU (SWALL:P37522) (253 aa) fasta scores: E(): 1.2e-44, 51.21% id in 248 aa; regulatory protein 1185667..1186536 Corynebacterium diphtheriae NCTC 13129 2649742 NP_939545.1 CDS DIP1188 NC_002935.2 1186579 1187397 D Similar to Mycobacterium tuberculosis hypothetical 30.6 kDa protein Rv1709 or MTCI125.31 SWALL:O33208 (EMBL:Z98268) (278 aa) fasta scores: E(): 2.2e-55, 60.31% id in 252 aa, and to Streptomyces coelicolor hypothetical 29.6 kDa protein SCI51.10c SWALL:Q9S230 (EMBL:AL109848) (264 aa) fasta scores: E(): 1.2e-46, 59.41% id in 239 aa; hypothetical protein 1186579..1187397 Corynebacterium diphtheriae NCTC 13129 2649743 NP_939546.1 CDS bioD1 NC_002935.2 1187512 1188117 D Similar to Corynebacterium glutamicum dethiobiotin synthetase BioD SWALL:BIOD_CORGL (SWALL:P46397) (224 aa) fasta scores: E(): 4e-08, 38.94% id in 208 aa, and to Streptomyces coelicolor dethiobiotin synthetase BioD SWALL:Q9FCC1 (EMBL:AL391014) (238 aa) fasta scores: E(): 3.6e-06, 28.37% id in 222 aa. Note: Similar to the downstream CDS DIP1192, 222 aa; E(): 1.3e-13; 38.914% identity in 221 aa overlap - possible duplication; dethiobiotin synthetase 1187512..1188117 Corynebacterium diphtheriae NCTC 13129 2649744 NP_939547.1 CDS DIP1190 NC_002935.2 1188118 1189614 R Similar to Bacillus subtilis hypothetical transporter YclF SWALL:YCLF_BACSU (SWALL:P94408) (492 aa) fasta scores: E(): 2e-53, 33.73% id in 495 aa, and to Neisseria meningitidis peptide transporter NMA0222 SWALL:Q9JWV5 (EMBL:AL162752) (485 aa) fasta scores: E(): 6.2e-47, 34.63% id in 488 aa; peptide transport protein complement(1188118..1189614) Corynebacterium diphtheriae NCTC 13129 2649745 NP_939548.1 CDS bioA NC_002935.2 1189692 1190987 D catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine-8-amino-7-oxononanoate aminotransferase 1189692..1190987 Corynebacterium diphtheriae NCTC 13129 2649746 NP_939549.1 CDS bioD NC_002935.2 1191000 1191668 D DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 1191000..1191668 Corynebacterium diphtheriae NCTC 13129 2649747 NP_939550.1 CDS DIP1193 NC_002935.2 1191785 1193359 D Similar to Streptomyces coelicolor Na+/H+ antiporter SC4A10.04c SWALL:Q9S2Y0 (EMBL:AL109663) (528 aa) fasta scores: E(): 1.2e-47, 39.09% id in 532 aa, and to Rhizobium loti Na+/H+ antiporter MLL3064 SWALL:Q98H22 (EMBL:AP003001) (517 aa) fasta scores: E(): 9.6e-31, 28.62% id in 531 aa; Na+/H+ antiporter 1191785..1193359 Corynebacterium diphtheriae NCTC 13129 2649748 NP_939551.1 CDS DIP1194 NC_002935.2 1193378 1193932 D Similar to Mycobacterium leprae hypothetical 25.3 kDa protein ML1369 or MLC1351.04C SWALL:O05669 (EMBL:Z95117) (231 aa) fasta scores: E(): 3.1e-33, 59.19% id in 174 aa, and to Bacillus halodurans BH1561 protein SWALL:Q9KCL0 (EMBL:AP001512) (197 aa) fasta scores: E(): 1.7e-13, 38.67% id in 181 aa; hypothetical protein 1193378..1193932 Corynebacterium diphtheriae NCTC 13129 2649749 NP_939552.1 CDS DIP1195 NC_002935.2 1194036 1195001 D Similar to Mycobacterium tuberculosis hypothetical 27.6 kDa protein Rv1711 or MT1751.1 or MTCI125.33 SWALL:YH11_MYCTU (SWALL:O33210) (254 aa) fasta scores: E(): 2.8e-52, 60.74% id in 242 aa, and to Bacillus subtilis ribosomal large subunit pseudouridine synthase B RluB SWALL:RLUB_BACSU (SWALL:P35159) (229 aa) fasta scores: E(): 2e-28, 46.72% id in 229 aa. Note: Alternative start codon at residue 55; pseudouridine synthase 1194036..1195001 Corynebacterium diphtheriae NCTC 13129 2649750 NP_939553.1 CDS cmk NC_002935.2 1195003 1195728 D Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 1195003..1195728 Corynebacterium diphtheriae NCTC 13129 2649751 NP_939554.1 CDS engA NC_002935.2 1195725 1197368 D synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 1195725..1197368 Corynebacterium diphtheriae NCTC 13129 2649752 NP_939555.1 CDS dcuB NC_002935.2 1197600 1198985 D functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters; anaerobic C4-dicarboxylate transporter 1197600..1198985 Corynebacterium diphtheriae NCTC 13129 2649753 NP_939556.1 CDS DIP1199 NC_002935.2 1199016 1200020 R Similar to, although longer in its N-terminal region than Mycobacterium tuberculosis methyltransferase Rv3342 or MT3445 or MTV016.42 SWALL:YX42_MYCTU (SWALL:O53392) (243 aa) fasta scores: E(): 2e-16, 31.71% id in 227 aa, and to Pseudomonas aeruginosa hypothetical protein PA0558 SWALL:Q9I5X8 (EMBL:AE004492) (255 aa) fasta scores: E(): 8.9e-11, 28.06% id in 253 aa; methyltransferase complement(1199016..1200020) Corynebacterium diphtheriae NCTC 13129 2649754 NP_939557.1 CDS DIP1200 NC_002935.2 1200019 1201269 D Similar to Corynebacterium glutamicum hypothetical 45.7 kDa protein in lysI 3'region SWALL:YLI2_CORGL (SWALL:P35866) (426 aa) fasta scores: E(): 4.7e-68, 46.93% id in 424 aa, and to Mycobacterium tuberculosis hypothetical 51.8 kDa protein Rv1639c or MTCY06H11.03c SWALL:P94973 (EMBL:Z85982) (489 aa) fasta scores: E(): 1.8e-16, 23.89% id in 385 aa; hypothetical protein 1200019..1201269 Corynebacterium diphtheriae NCTC 13129 2649755 NP_939558.1 CDS DIP1201 NC_002935.2 1201642 1202019 R Similar to Streptomyces coelicolor conserved hypothetical protein SCI52.19 SWALL:Q9AD90 (EMBL:AL590507) (124 aa) fasta scores: E(): 2.7e-20, 49.58% id in 121 aa, and to Escherichia coli hypothetical protein YchJ or B1233 SWALL:YCHJ_ECOLI (SWALL:P37052) (152 aa) fasta scores: E(): 7.6e-15, 38.71% id in 124 aa; hypothetical protein complement(1201642..1202019) Corynebacterium diphtheriae NCTC 13129 2649757 NP_939559.1 CDS DIP1202 NC_002935.2 1202026 1203213 R Similar to Rhizobium meliloti hypothetical protein RA1044 or SMA1898 SWALL:AAK65702 (EMBL:AE007290) (408 aa) fasta scores: E(): 8.8e-49, 39.34% id in 399 aa, and to Clostridium acetobutylicum alpha/beta superfamily hydrolase CAC3665 SWALL:AAK81587 (EMBL:AE007861) (265 aa) fasta scores: E(): 2.6e-07, 22.43% id in 263 aa; hypothetical protein complement(1202026..1203213) Corynebacterium diphtheriae NCTC 13129 2649758 NP_939560.1 CDS secA2 NC_002935.2 1203482 1205776 D SecA2; functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond to SecA2; which is non-essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 1203482..1205776 Corynebacterium diphtheriae NCTC 13129 2649759 NP_939561.1 CDS DIP1204 NC_002935.2 1205943 1206374 D Similar to Mycobacterium smegmatis signal transduction protein GarA SWALL:Q9RP36 (EMBL:AF173844) (158 aa) fasta scores: E(): 6.6e-34, 68.21% id in 151 aa, and to Mycobacterium tuberculosis hypothetical 17.3 kDa protein Rv1827 or MT1875 or MTCY1A11.16c SWALL:YI27_MYCTU (SWALL:Q50606) (162 aa) fasta scores: E(): 3.7e-32, 67.83% id in 143 aa; signal transduction protein 1205943..1206374 Corynebacterium diphtheriae NCTC 13129 2649760 NP_939562.1 CDS DIP1205 NC_002935.2 1206545 1207222 D Similar to Streptomyces coelicolor hypothetical 26.5 kDa protein SC1A8A.03c SWALL:Q9KZP9 (EMBL:AL353861) (246 aa) fasta scores: E(): 1.4e-27, 41.44% id in 222 aa, and to Mycobacterium tuberculosis hypothetical 26.4 kDa protein Rv1828 or MT1876 or MTCY1A11.15c SWALL:YI28_MYCTU (SWALL:Q50605) (247 aa) fasta scores: E(): 1.2e-14, 40.25% id in 236 aa; MerR family transcriptional regulator 1206545..1207222 Corynebacterium diphtheriae NCTC 13129 2649761 NP_939563.1 CDS DIP1206 NC_002935.2 1207245 1207832 D Similar to Mycobacterium leprae hypothetical 18.1 kDa protein ML2074 or MLCB1788.34c SWALL:O32917 (EMBL:AL008609) (164 aa) fasta scores: E(): 7.8e-13, 32.02% id in 153 aa, and to Mycobacterium tuberculosis hypothetical 18.1 kDa protein Rv1829 or MT1877 or MTCY1A11.14c SWALL:YI29_MYCTU (SWALL:Q50604) (164 aa) fasta scores: E(): 9.1e-13, 34.07% id in 135 aa; hypothetical protein 1207245..1207832 Corynebacterium diphtheriae NCTC 13129 2649762 NP_939564.1 CDS DIP1207 NC_002935.2 1207984 1208544 D Similar to Mycobacterium tuberculosis hypothetical 24.0 kDa protein Rv1830 or MT1879 or MTCY1A11.13c SWALL:YI30_MYCTU (SWALL:Q50603) (225 aa) fasta scores: E(): 1.5e-41, 72.98% id in 174 aa, and to Bacillus subtilis regulatory protein GlnR SWALL:GLNR_BACSU (SWALL:P37582) (135 aa) fasta scores: E(): 0.22, 29.16% id in 72 aa; transcriptional regulator 1207984..1208544 Corynebacterium diphtheriae NCTC 13129 2649763 NP_939565.1 CDS DIP1208 NC_002935.2 1208620 1210032 R hypothetical protein complement(1208620..1210032) Corynebacterium diphtheriae NCTC 13129 2649764 NP_939566.1 CDS DIP1209 NC_002935.2 1210064 1210942 R Similar to Rhodococcus fascians hypothetical 34.0 kDa protein SWALL:Q9AE56 (EMBL:AJ301559) (304 aa) fasta scores: E(): 2.2e-46, 44.91% id in 285 aa; hypothetical protein complement(1210064..1210942) Corynebacterium diphtheriae NCTC 13129 2649765 NP_939567.1 CDS DIP1210 NC_002935.2 1210939 1211991 R Similar to Rhodococcus fascians hypothetical 40.3 kDa protein SWALL:Q9AE57 (EMBL:AJ301559) (380 aa) fasta scores: E(): 5.4e-62, 50.28% id in 348 aa, to Streptomyces coelicolor integral membrane protein SC6D7.04 SWALL:Q9RKZ3 (EMBL:AL133213) (347 aa) fasta scores: E(): 8.2e-47, 40.93% id in 342 aa, and to Bacillus subtilis hypothetical 49.9 kDa protein in citA-sspB intergenic region YhdP SWALL:YHDP_BACSU (SWALL:O07585) (444 aa) fasta scores: E(): 5.3e-34, 34.48% id in 348 aa; hypothetical protein complement(1210939..1211991) Corynebacterium diphtheriae NCTC 13129 2649766 NP_939568.1 CDS DIP1211 NC_002935.2 1211988 1213382 R Similar to Mycobacterium tuberculosis hypothetical 48.1 kDa protein Rv1842c or MT1890 or MTCY1A11.02 or MTCY359.31 SWALL:YI42_MYCTU (SWALL:Q50592) (455 aa) fasta scores: E(): 8.3e-77, 49.55% id in 444 aa, and to Myxococcus xanthus hemolysin TlyC SWALL:AAK64446 (EMBL:AF377339) (463 aa) fasta scores: E(): 9.4e-38, 34.74% id in 449 aa; hypothetical protein complement(1211988..1213382) Corynebacterium diphtheriae NCTC 13129 2649767 NP_939569.1 CDS DIP1212 NC_002935.2 1213407 1214765 R Similar to Streptomyces coelicolor SC10A5.25c protein SWALL:O54116 (EMBL:AL021529) (498 aa) fasta scores: E(): 6.5e-63, 46.93% id in 424 aa, and to Escherichia coli ATP-dependent RNA helicase RhlE or B0797 SWALL:RHLE_ECOLI (SWALL:P25888) (454 aa) fasta scores: E(): 7.6e-44, 36.06% id in 452 aa; RNA helicase complement(1213407..1214765) Corynebacterium diphtheriae NCTC 13129 2649768 NP_939570.1 CDS gnd NC_002935.2 1214868 1216322 R catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase complement(1214868..1216322) Corynebacterium diphtheriae NCTC 13129 2649769 NP_939571.1 CDS DIP1214 NC_002935.2 1216431 1216889 D Similar to Mycobacterium tuberculosis hypothetical 15.1 kDa protein Rv1847 or MT1895 or MTCY359.26c SWALL:YI47_MYCTU (SWALL:P95162) (140 aa) fasta scores: E(): 1.6e-08, 34.67% id in 124 aa, and to Pseudomonas aeruginosa hypothetical protein PA1618 SWALL:YG18_PSEAE (SWALL:Q9I3A4) (145 aa) fasta scores: E(): 2e-05, 32.82% id in 131 aa; hypothetical protein 1216431..1216889 Corynebacterium diphtheriae NCTC 13129 2649770 NP_939572.1 CDS DIP1215 NC_002935.2 1216886 1217986 R Similar to Mycobacterium tuberculosis magnesium and cobalt transport protein CorA or Rv1239c or MT1277 or MTV006.11c SWALL:O50455 (EMBL:AL021006) (366 aa) fasta scores: E(): 1.9e-59, 43.45% id in 359 aa, and to Escherichia coli magnesium and cobalt transport protein CorA or B3816 or Z5333 or ECS4746 SWALL:CORA_ECOLI (SWALL:P27841) (316 aa) fasta scores: E(): 3e-05, 24.03% id in 312 aa; magnesium/cobalt transporter CorA complement(1216886..1217986) Corynebacterium diphtheriae NCTC 13129 2649771 NP_939573.1 CDS DIP1216 NC_002935.2 1217993 1218622 D Low similarity to Agrobacterium tumefaciens StrC58 AGR_C_2998p SWALL:AAK87404 (EMBL:AE008084) (321 aa) fasta scores: E(): 2.8e-06, 31.33% id in 150 aa, and to Rhizobium meliloti hypothetical protein RB0059 or SMB20059 SWALL:CAC48459 (EMBL:AL603642) (259 aa) fasta scores: E(): 6.5e-05, 28.67% id in 143 aa; hypothetical protein 1217993..1218622 Corynebacterium diphtheriae NCTC 13129 2649772 NP_939574.1 CDS ndh NC_002935.2 1218699 1220063 R Similar to Corynebacterium glutamicum NADH dehydrogenase Ndh SWALL:Q9X710 (EMBL:AJ238250) (467 aa) fasta scores: E(): 2.7e-137, 78.71% id in 451 aa, and to Escherichia coli NADH dehydrogenase Ndh or B1109 SWALL:DHNA_ECOLI (SWALL:P00393) (433 aa) fasta scores: E(): 4.9e-20, 27.08% id in 443 aa; NADH dehydrogenase complement(1218699..1220063) Corynebacterium diphtheriae NCTC 13129 2649773 NP_939575.1 CDS DIP1218 NC_002935.2 1220241 1221536 D Low similarity to Mycobacterium tuberculosis cyclopropane fatty acid synthase UfaA1 or Rv0447c or MT0463 or MTV037.11C SWALL:O53732 (EMBL:AL021932) (427 aa) fasta scores: E(): 2.2e-13, 27.14% id in 431 aa, and to Agrobacterium tumefaciens StrC58 AGR_C_3601p SWALL:AAK87737 (EMBL:AE008115) (410 aa) fasta scores: E(): 5.1e-06, 21.91% id in 356 aa; hypothetical protein 1220241..1221536 Corynebacterium diphtheriae NCTC 13129 2649774 NP_939576.1 CDS DIP1221 NC_002935.2 1222345 1223313 D Similar to Salmonella typhimurium Na+-dependent transporter STM4195 SWALL:AAL23019 (EMBL:AE008896) (313 aa) fasta scores: E(): 8e-40, 41.43% id in 292 aa, and to Bacillus halodurans sodium-dependent transporter BH0858 SWALL:Q9KEJ4 (EMBL:AP001510) (323 aa) fasta scores: E(): 1.1e-38, 41.29% id in 293 aa; sodium-dependent transport membrane protein 1222345..1223313 Corynebacterium diphtheriae NCTC 13129 2649776 NP_939577.1 CDS DIP1222 NC_002935.2 1223713 1223895 R hypothetical protein complement(1223713..1223895) Corynebacterium diphtheriae NCTC 13129 2649777 NP_939578.1 CDS DIP1223 NC_002935.2 1223913 1224611 R Low similarity to Xylella fastidiosa hypothetical protein XF1327 SWALL:Q9PDQ2 (EMBL:AE003965) (189 aa) fasta scores: E(): 0.14, 25.23% id in 210 aa, and to Streptomyces coelicolor hypothetical 28.6 kDa protein 2SC10A7.34c SWALL:Q9ADM8 (EMBL:AL583945) (273 aa) fasta scores: E(): 0.23, 25.11% id in 215 aa; hypothetical protein complement(1223913..1224611) Corynebacterium diphtheriae NCTC 13129 2649778 NP_939579.1 CDS DIP1224 NC_002935.2 1224625 1224966 R Similar to Mycobacterium tuberculosis CDC1551 hypothetical 13.2 kDa protein MT2109 SWALL:AAK46388 (EMBL:AE007062) (120 aa) fasta scores: E(): 5e-15, 43.92% id in 107 aa; hypothetical protein complement(1224625..1224966) Corynebacterium diphtheriae NCTC 13129 2649779 NP_939580.1 CDS DIP1225 NC_002935.2 1225219 1225608 D Similar to Mycobacterium tuberculosis hypothetical 13.0 kDa protein Rv2050 or MTV018.37 SWALL:O53492 (EMBL:AL021899) (111 aa) fasta scores: E(): 6.5e-28, 70% id in 110 aa, and to Mycobacterium leprae hypothetical protein ML1439 SWALL:Q9CC05 (EMBL:AL583922) (111 aa) fasta scores: E(): 2.9e-27, 68.18% id in 110 aa; hypothetical protein 1225219..1225608 Corynebacterium diphtheriae NCTC 13129 2649780 NP_939581.1 CDS ppm1 NC_002935.2 1225684 1226487 R Similar to Mycobacterium smegmatis polyprenol phosphate mannosyl transferase 1 Ppm1 SWALL:Q9F408 (EMBL:AJ294477) (265 aa) fasta scores: E(): 1.6e-56, 61.6% id in 237 aa, and to Schizosaccharomyces pombe dolichol-phosphate mannosyltransferase Dpm1 or SPAC31G5.16c SWALL:O14466 (EMBL:AF007873) (236 aa) fasta scores: E(): 1.2e-24, 39.54% id in 220 aa; polyprenol phosphate mannosyl transferase 1 complement(1225684..1226487) Corynebacterium diphtheriae NCTC 13129 2649781 NP_939582.1 CDS DIP1227 NC_002935.2 1226513 1228072 R Similar to Streptomyces coelicolor transferase 2SCG2.28c SWALL:Q9EX26 (EMBL:AL445963) (537 aa) fasta scores: E(): 2.4e-42, 37.71% id in 517 aa, and to Escherichia coli apolipoprotein N-acyltransferase Lnt or CutE or B0657 SWALL:LNT_ECOLI (SWALL:P23930) (512 aa) fasta scores: E(): 1.6e-19, 25.89% id in 533 aa; transferase/membrane protein complement(1226513..1228072) Corynebacterium diphtheriae NCTC 13129 2649782 NP_939583.1 CDS fxsA NC_002935.2 1228082 1228612 R F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA protein complement(1228082..1228612) Corynebacterium diphtheriae NCTC 13129 2649783 NP_939584.1 CDS cobN NC_002935.2 1228651 1232283 R with CobST catalyzes the formation of cobyrinic acid a,c-diamide from hydrogenobyrinic acid a,c-diamide in an ATP-dependent manner; involved in porphyrin and chlorophyll metabolism; vitamin B12 metabolism; cobaltochelatase subunit CobN complement(1228651..1232283) Corynebacterium diphtheriae NCTC 13129 2649784 NP_939585.1 CDS DIP1230 NC_002935.2 1232340 1232477 D Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 1232340..1232477 Corynebacterium diphtheriae NCTC 13129 2649785 NP_939586.1 CDS DIP1231 NC_002935.2 1232650 1233843 D Similar to Mycobacterium tuberculosis CDC1551 CobG-related protein MT2124 SWALL:AAK46404 (EMBL:AE007063) (363 aa) fasta scores: E(): 5.1e-43, 39.56% id in 369 aa; hypothetical protein 1232650..1233843 Corynebacterium diphtheriae NCTC 13129 2649786 NP_939587.1 CDS cobH NC_002935.2 1233840 1234490 D catalyzes the interconversion of precorrin-8X and hydrogenobyrinate; precorrin-8X methylmutase 1233840..1234490 Corynebacterium diphtheriae NCTC 13129 2649787 NP_939588.1 CDS cobIJ NC_002935.2 1234487 1235983 D Similar to Mycobacterium tuberculosis cobalamin biosynthesis protein [includes: precorrin-2 C20- methyltransferase; precorrin-3 methylase] CobIJ or Rv2066 or MT2126 or MTCY49.05 SWALL:COBI_MYCTU (SWALL:Q10677) (508 aa) fasta scores: E(): 3.6e-88, 50.7% id in 495 aa, C-terminal region to Rhodobacter capsulatus precorrin-3 methylase SWALL:O68097 (EMBL:AF010496) (245 aa) fasta scores: E(): 1.1e-34, 48.14% id in 243 aa, and N-terminal region to Pseudomonas aeruginosa precorrin-2 methyltransferase CobI or PA2904 SWALL:Q9HZU3 (EMBL:AE004716) (250 aa) fasta scores: E(): 1.4e-33, 43.3% id in 254 aa; bifunctional cobalamin biosynthesis protein 1234487..1235983 Corynebacterium diphtheriae NCTC 13129 2649788 NP_939589.1 CDS cobK NC_002935.2 1236065 1236796 R CobK/CbiJ; there are 2 pathways for cobalamin (vitamin B12) production, one aerobic (ex. P. denitrificans), the other anaerobic (ex. S. typhimurium); the CobK/CbiJ perform similar reactions in both; the anaerobic pathway includes the use of a chelated cobalt ion in order for ring contraction to occur; CobK thus converts precorrin 6 into dihydro-precorrin 6 while CbiJ converts cobalt-precorrin 6 into cobalt-deihydro-precorrin 6; cobalt-precorrin-6x reductase complement(1236065..1236796) Corynebacterium diphtheriae NCTC 13129 2649789 NP_939590.1 CDS cobM NC_002935.2 1236784 1237557 R Similar to Pseudomonas denitrificans precorrin-4 C11-methyltransferase CobM SWALL:COBM_PSEDE (SWALL:P21922) (253 aa) fasta scores: E(): 5.4e-46, 55.37% id in 251 aa, and to Rhodococcus erythropolis precorrin-4 C11-methyltransferase CobM SWALL:COBM_RHOER (SWALL:Q53138) (249 aa) fasta scores: E(): 3.4e-57, 61.04% id in 249 aa; precorrin-4 C(11)-methyltransferase complement(1236784..1237557) Corynebacterium diphtheriae NCTC 13129 2649790 NP_939591.1 CDS DIP1236 NC_002935.2 1237585 1238832 R Similar to Mycobacterium tuberculosis precorrin-6Y C5,15-methyltransferase [decarboxylating] CobL or Rv2072c or MT2132 or MTCY49.11c SWALL:COBL_MYCTU (SWALL:Q10671) (390 aa) fasta scores: E(): 5.8e-57, 44.22% id in 398 aa, and to Pseudomonas denitrificans precorrin-6Y C5,15-methyltransferase [decarboxylating] CobL SWALL:COBL_PSEDE (SWALL:P21921) (413 aa) fasta scores: E(): 1.5e-47, 39.5% id in 405 aa; precorrin-6Y C5,15-methyltransferase complement(1237585..1238832) Corynebacterium diphtheriae NCTC 13129 2649791 NP_939592.1 CDS DIP1237 NC_002935.2 1238888 1239652 R probable dehydrogenase; hypothetical protein complement(1238888..1239652) Corynebacterium diphtheriae NCTC 13129 2649792 NP_939593.1 CDS DIP1238 NC_002935.2 1239661 1240800 R Similar to Mycobacterium tuberculosis probable dipeptidase Rv2089c or MT2150 or MTCY49.29c SWALL:YK89_MYCTU (SWALL:Q10698) (375 aa) fasta scores: E(): 3.1e-56, 49.86% id in 377 aa, and to Halobacterium sp probable peptidase PepQ1 or Vng0723g SWALL:Q9HRF6 (EMBL:AE005016) (369 aa) fasta scores: E(): 2.2e-37, 38.62% id in 378 aa; dipeptidase complement(1239661..1240800) Corynebacterium diphtheriae NCTC 13129 2649793 NP_939594.1 CDS DIP1239 NC_002935.2 1240851 1243643 R Similar to Mycobacterium tuberculosis probable helicase HelY or Rv2092c or MT2153 or MTCY49.30c SWALL:HELY_MYCTU (SWALL:Q10701) (906 aa) fasta scores: E(): 4.5e-69, 48.87% id in 933 aa, and to Synechocystis sp antiviral protein Ski2 or SLR0451 SWALL:P74686 (EMBL:D90917) (1006 aa) fasta scores: E(): 2.3e-27, 29.42% id in 1040 aa; helicase complement(1240851..1243643) Corynebacterium diphtheriae NCTC 13129 2649794 NP_939595.1 CDS DIP1240 NC_002935.2 1243744 1244214 D Similar to Mycobacterium leprae tRNA/rRNA methyltransferase ML0419 SWALL:Q9CCU7 (EMBL:AL583918) (158 aa) fasta scores: E(): 7.7e-35, 58.71% id in 155 aa, and to Escherichia coli hypothetical tRNA/rRNA methyltransferase YibK or B3606 SWALL:YIBK_ECOLI (SWALL:P33899) (157 aa) fasta scores: E(): 3.3e-28, 50% id in 152 aa; tRNA/rRNA methyltransferase 1243744..1244214 Corynebacterium diphtheriae NCTC 13129 2649795 NP_939596.1 CDS tatC NC_002935.2 1244300 1245394 R Similar to, although longer in its C-terminal region than Mycobacterium tuberculosis Sec-independent protein translocase TatC homolog or Rv2093c or MT2154 or MTCY49.33c SWALL:TATC_MYCTU (SWALL:Q10702) (308 aa) fasta scores: E(): 1.6e-54, 56.55% id in 290 aa, and to Escherichia coli Sec-independent protein translocase TatC or MttB or B3839 or Z5360 or ECS4768 SWALL:TATC_ECOLI (SWALL:P27857) (258 aa) fasta scores: E(): 9.3e-14, 28.04% id in 271 aa; Sec-independent twin-arginine translocase system protein complement(1244300..1245394) Corynebacterium diphtheriae NCTC 13129 2649796 NP_939597.1 CDS tatA NC_002935.2 1245467 1245733 R TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin-arginine translocation protein TatA complement(1245467..1245733) Corynebacterium diphtheriae NCTC 13129 2649797 NP_939598.1 CDS DIP1243 NC_002935.2 1245768 1246727 R Similar to Rhodococcus erythropolis ORF11 SWALL:P72265 (EMBL:Z82004) (326 aa) fasta scores: E(): 1.3e-24, 31.42% id in 315 aa, and to Mycobacterium tuberculosis hypothetical 33.8 kDa protein Rv2095c precursor or MT2156 or MTCY49.35c SWALL:YK95_MYCTU (SWALL:Q10704) (316 aa) fasta scores: E(): 3.4e-24, 31.57% id in 304 aa; hypothetical protein complement(1245768..1246727) Corynebacterium diphtheriae NCTC 13129 2649798 NP_939599.1 CDS DIP1244 NC_002935.2 1246792 1247769 R Similar to Rhodococcus erythropolis ORF10 SWALL:P72264 (EMBL:Z82004) (330 aa) fasta scores: E(): 6.6e-20, 31.42% id in 331 aa, and to Mycobacterium leprae hypothetical 35.4 kDa protein ML1329 or MLCB2533.25 or B2126_C3_266 SWALL:YK96_MYCLE (SWALL:P54076) (331 aa) fasta scores: E(): 2.8e-19, 30.42% id in 332 aa; hypothetical protein complement(1246792..1247769) Corynebacterium diphtheriae NCTC 13129 2649799 NP_939600.1 CDS DIP1245 NC_002935.2 1247794 1249233 R Similar to Rhodococcus erythropolis ORF9 SWALL:P72270 (EMBL:Z82005) (447 aa) fasta scores: E(): 8.7e-96, 55.7% id in 456 aa, and to Mycobacterium tuberculosis hypothetical 51.4 kDa protein Rv2097c or MT2158 or MTCY49.37c SWALL:YK97_MYCTU (SWALL:Q10706) (452 aa) fasta scores: E(): 8.8e-96, 54.56% id in 460 aa; hypothetical protein complement(1247794..1249233) Corynebacterium diphtheriae NCTC 13129 2649800 NP_939601.1 CDS DIP1246 NC_002935.2 1249238 1249432 R Similar to Mycobacterium smegmatis hypothetical 7.0 kDa protein PrcS SWALL:O30517 (EMBL:AF009645) (64 aa) fasta scores: E(): 3.2e-07, 60.71% id in 56 aa, and to Rhodococcus erythropolis similar to ORF7 SWALL:Q53082 (EMBL:U26422) (64 aa) fasta scores: E(): 1.6e-06, 55% id in 60 aa; hypothetical protein complement(1249238..1249432) Corynebacterium diphtheriae NCTC 13129 2649801 NP_939602.1 CDS DIP1247 NC_002935.2 1249490 1251016 R Similar to Rhodococcus erythropolis similar to ORF6 SWALL:Q53081 (EMBL:U26422) (499 aa) fasta scores: E(): 2.2e-72, 48.04% id in 512 aa, and to Frankia spACN14A/ts-r. hypothetical 56.4 kDa protein SWALL:Q9RAW9 (EMBL:AF142435) (505 aa) fasta scores: E(): 3.8e-51, 47.36% id in 494 aa; hypothetical protein complement(1249490..1251016) Corynebacterium diphtheriae NCTC 13129 2649802 NP_939603.1 CDS DIP1248 NC_002935.2 1251013 1252542 R Similar to, although shorter in its N-terminal region than Streptomyces coelicolor AAA protein family ATPase Arc SWALL:Q9RJ58 (EMBL:AL132648) (588 aa) fasta scores: E(): 3e-76, 54.14% id in 519 aa, and to, although shorter in its N-terminal region than Mycobacterium leprae AAA-family ATPase ML1316 or MLCB2533.12 or A2126A or B2126_C1_167 SWALL:YL15_MYCLE (SWALL:P46509) (609 aa) fasta scores: E(): 2.1e-58, 54.99% id in 531 aa; ATPase complement(1251013..1252542) Corynebacterium diphtheriae NCTC 13129 2649803 NP_939604.1 CDS DIP1249 NC_002935.2 1252639 1253475 R Similar to Rhodococcus erythropolis hypothetical 35.2 kDa protein SWALL:Q9ZG14 (EMBL:AF088800) (324 aa) fasta scores: E(): 7.9e-71, 65.45% id in 275 aa, and to Mycobacterium tuberculosis hypothetical 30.1 kDa protein Rv2118c or MTCY261.14c SWALL:O33253 (EMBL:Z97559) (280 aa) fasta scores: E(): 2.6e-62, 58.27% id in 278 aa; hypothetical protein complement(1252639..1253475) Corynebacterium diphtheriae NCTC 13129 2649804 NP_939605.1 CDS DIP1250 NC_002935.2 1253482 1254840 R catalyzes the removal of amino acids from the N termini of peptides; aminopeptidase complement(1253482..1254840) Corynebacterium diphtheriae NCTC 13129 2649805 NP_939606.1 CDS DIP1251 NC_002935.2 1254942 1255808 D Similar to Mycobacterium tuberculosis hypothetical 30.9 kDa protein Rv2119 or MTCY261.15 SWALL:O33254 (EMBL:Z97559) (278 aa) fasta scores: E(): 9e-48, 48.16% id in 272 aa, and to Streptomyces coelicolor hypothetical 31.9 kDa protein SCI41.36 SWALL:Q9RJ55 (EMBL:AL132648) (284 aa) fasta scores: E(): 2.8e-45, 47.34% id in 264 aa; hypothetical protein 1254942..1255808 Corynebacterium diphtheriae NCTC 13129 2649806 NP_939607.1 CDS DIP1252 NC_002935.2 1255902 1256171 D Low similarity to Caulobacter crescentus virulence-associated protein, CC2867 SWALL:Q9A4G7 (EMBL:AE005951) (104 aa) fasta scores: E(): 0.00032, 29.26% id in 82 aa, and to Bacteroides nodosus virulence-associated protein I VapI SWALL:VAPI_BACNO (SWALL:Q46560) (108 aa) fasta scores: E(): 0.0023, 27.58% id in 87 aa; virulence-associated protein 1255902..1256171 Corynebacterium diphtheriae NCTC 13129 2649807 NP_939608.1 CDS fhs NC_002935.2 1256231 1257883 R catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate; formate--tetrahydrofolate ligase complement(1256231..1257883) Corynebacterium diphtheriae NCTC 13129 2649808 NP_939609.1 CDS aspA NC_002935.2 1258020 1259594 R catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase complement(1258020..1259594) Corynebacterium diphtheriae NCTC 13129 2649809 NP_939610.1 CDS dcuA NC_002935.2 1259869 1261176 R functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB; anaerobic C4-dicarboxylate transporter complement(1259869..1261176) Corynebacterium diphtheriae NCTC 13129 2649810 NP_939611.1 CDS hisG NC_002935.2 1261537 1262382 R long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase complement(1261537..1262382) Corynebacterium diphtheriae NCTC 13129 2649811 NP_939612.1 CDS hisE NC_002935.2 1262464 1262727 R catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis; phosphoribosyl-ATP pyrophosphatase complement(1262464..1262727) Corynebacterium diphtheriae NCTC 13129 2650087 NP_939613.1 CDS DIP1258 NC_002935.2 1262746 1263441 R Similar to Streptomyces coelicolor hydrolase SCI46.01c SWALL:Q9EWH4 (EMBL:AL499607) (233 aa) fasta scores: E(): 4.7e-15, 32.8% id in 189 aa, and to Rhodobacter capsulatus CbbY protein SWALL:CBBY_RHOCA (SWALL:O33513) (227 aa) fasta scores: E(): 1.6e-11, 33.65% id in 205 aa; hydrolase complement(1262746..1263441) Corynebacterium diphtheriae NCTC 13129 2649812 NP_939614.1 CDS metH NC_002935.2 1263485 1267090 R Similar to Mycobacterium tuberculosis 5-methyltetrahydrofolate--homocysteine methyltransferase MetH or Rv2124c or MTCY261.20c SWALL:METH_MYCTU (SWALL:O33259) (1192 aa) fasta scores: E(): 0, 70.85% id in 1194 aa, and to Escherichia coli 5-methyltetrahydrofolate--homocysteine methyltransferase MetH or B4019 SWALL:METH_ECOLI (SWALL:P13009) (1226 aa) fasta scores: E(): 2.8e-92, 32.4% id in 1225 aa; 5-methyltetrahydrofolate--homocysteine methyltransferase complement(1263485..1267090) Corynebacterium diphtheriae NCTC 13129 2649813 NP_939615.1 CDS DIP1260 NC_002935.2 1267163 1267558 R Similar to the plasmid borne Corynebacterium striatum YtpA SWALL:Q9FB56 (EMBL:AF024666) (132 aa) fasta scores: E(): 7.6e-12, 37.19% id in 121 aa; hypothetical protein complement(1267163..1267558) Corynebacterium diphtheriae NCTC 13129 2649814 NP_939616.1 CDS cysS NC_002935.2 1267559 1268803 R catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase complement(1267559..1268803) Corynebacterium diphtheriae NCTC 13129 2649815 NP_939617.1 CDS uppP NC_002935.2 1268849 1269697 R BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase complement(1268849..1269697) Corynebacterium diphtheriae NCTC 13129 2649816 NP_939618.1 CDS DIP1263 NC_002935.2 1269829 1270878 D Similar to Corynebacterium striatum LppL SWALL:Q9EVJ8 (EMBL:AF024666) (350 aa) fasta scores: E(): 4.3e-35, 34.21% id in 342 aa; lipoprotein 1269829..1270878 Corynebacterium diphtheriae NCTC 13129 2649817 NP_939619.1 CDS pyrD NC_002935.2 1270943 1272034 D catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 1270943..1272034 Corynebacterium diphtheriae NCTC 13129 2649818 NP_939620.1 CDS DIP1265 NC_002935.2 1272452 1272991 R Similar to Corynebacterium striatum YbhB SWALL:Q9FB60 (EMBL:AF024666) (177 aa) fasta scores: E(): 5.1e-42, 60.67% id in 178 aa, and to Vibrio cholerae hypothetical protein VC1075 SWALL:Q9KT30 (EMBL:AE004189) (180 aa) fasta scores: E(): 1.2e-19, 41.1% id in 163 aa; hypothetical protein complement(1272452..1272991) Corynebacterium diphtheriae NCTC 13129 2649819 NP_939621.1 CDS DIP1266 NC_002935.2 1273380 1274759 D Similar to, although shorter in its N-terminal region than Escherichia coli possible transposase of IS1353 YahA SWALL:Q9WTH9 (EMBL:AP000342) (514 aa) fasta scores: E(): 2.5e-62, 41.59% id in 464 aa, and similar to, although longer in its N-terminal region than Escherichia coli transposase InsK for insertion sequence element IS150 or B3558 SWALL:INSK_ECOLI (SWALL:P19769) (283 aa) fasta scores: E(): 2.6e-35, 38.62% id in 277 aa; transposase 1273380..1274759 Corynebacterium diphtheriae NCTC 13129 2649821 NP_939622.1 CDS DIP1270 NC_002935.2 1276058 1276807 R Similar to, although sorter in its N-terminal region than Vibrio cholerae thiosulfate sulfurtransferase SseA, VCA0620 SWALL:Q9KLX1 (EMBL:AE004392) (276 aa) fasta scores: E(): 6.9e-30, 38.72% id in 235 aa, and than Escherichia coli O157:H7 3-mercaptopyruvate sulfurtransferase SseA or Z3788 or ECS3387 SWALL:AAG57635 (EMBL:AE005482) (334 aa) fasta scores: E(): 2e-27, 38.65% id in 238 aa. Note: In the database matches for this CDS, the non-catalitic domain lies in the N-terminal region of the protein, hence this CDS being shorter in that region should not suppose a change in the possible catalytic activity, mostly if we consider that the possibly active-site residue 204 (cysteine) lies within the almost conserved region (CGCGVTA in E. coli and CGSRVTA in C. diphtheriae) possibly responsible for substrate specificity; sulfurtransferase complement(1276058..1276807) Corynebacterium diphtheriae NCTC 13129 2649823 NP_939623.1 CDS DIP1271 NC_002935.2 1276921 1277925 R functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins; arginine/ornithine transport system ATPase complement(1276921..1277925) Corynebacterium diphtheriae NCTC 13129 2649824 NP_939624.1 CDS sbm NC_002935.2 1278111 1280318 R MDM; functions in conversion of succinate to propionate; methylmalonyl-CoA mutase complement(1278111..1280318) Corynebacterium diphtheriae NCTC 13129 2649825 NP_939625.1 CDS DIP1273 NC_002935.2 1280321 1282132 R Similar to Mycobacterium tuberculosis probable methylmalonyl-CoA mutase small subunit MutA or Rv1492 or MT1539 or MTCY277.14 SWALL:MUTA_MYCTU (SWALL:P71773) (615 aa) fasta scores: E(): 1.5e-69, 43.15% id in 621 aa, and to Porphyromonas gingivalis methylmalonyl-CoA mutase small subunit MutA or McmA SWALL:MUTA_PORGI (SWALL:Q59676) (617 aa) fasta scores: E(): 4.9e-31, 30.73% id in 628 aa; methylmalonyl-CoA mutase small subunit complement(1280321..1282132) Corynebacterium diphtheriae NCTC 13129 2649826 NP_939626.1 CDS DIP1274 NC_002935.2 1282382 1283083 D Similar to Mycobacterium tuberculosis hypothetical 26.6 kDa protein Rv1491c or MT1538 or MTCY277.13c SWALL:YE91_MYCTU (SWALL:P71772) (252 aa) fasta scores: E(): 2.5e-24, 36.09% id in 205 aa, and to Streptomyces coelicolor integral membrane protein 2SCG61.05c SWALL:Q9K410 (EMBL:AL359949) (258 aa) fasta scores: E(): 2.3e-10, 28.09% id in 210 aa; hypothetical protein 1282382..1283083 Corynebacterium diphtheriae NCTC 13129 2649827 NP_939627.1 CDS DIP1275 NC_002935.2 1283144 1283710 D DNA-binding protein 1283144..1283710 Corynebacterium diphtheriae NCTC 13129 2649828 NP_939628.1 CDS DIP1276 NC_002935.2 1283795 1284922 R Similar to Mycobacterium tuberculosis hypothetical 41.2 kDa protein Rv1488 or MT1533.2 or MTCY277.09 SWALL:YE88_MYCTU (SWALL:P71768) (381 aa) fasta scores: E(): 1.4e-79, 62.53% id in 363 aa, and to Pyrococcus abyssi stomatin-like protein PAB1324 SWALL:Q9UYE4 (EMBL:AJ248288) (299 aa) fasta scores: E(): 2.7e-35, 42.65% id in 279 aa; hypothetical protein complement(1283795..1284922) Corynebacterium diphtheriae NCTC 13129 2649829 NP_939629.1 CDS DIP1277 NC_002935.2 1284919 1285353 R Similar to Mycobacterium avium MAV145 SWALL:O07404 (EMBL:AF002133) (145 aa) fasta scores: E(): 2.2e-11, 35.25% id in 139 aa, and to Streptomyces coelicolor integral membrane protein SC2H12.25 SWALL:Q9K459 (EMBL:AL359215) (146 aa) fasta scores: E(): 7.4e-11, 33.08% id in 136 aa; hypothetical protein complement(1284919..1285353) Corynebacterium diphtheriae NCTC 13129 2649830 NP_939630.1 CDS DIP1278 NC_002935.2 1285420 1286262 R Similar to Streptomyces coelicolor hypothetical 29.4 kDa protein SCC77.24 SWALL:Q9RDD4 (EMBL:AL136503) (274 aa) fasta scores: E(): 1.3e-46, 50.57% id in 259 aa, and to Mycobacterium tuberculosis hypothetical 30.5 kDa protein Rv2033c or MTV018.20 SWALL:O53477 (EMBL:AL021899) (280 aa) fasta scores: E(): 6.7e-37, 46.78% id in 280 aa; hypothetical protein complement(1285420..1286262) Corynebacterium diphtheriae NCTC 13129 2649831 NP_939631.1 CDS DIP1279 NC_002935.2 1286298 1287083 D hypothetical protein 1286298..1287083 Corynebacterium diphtheriae NCTC 13129 2649832 NP_939632.1 CDS hemH NC_002935.2 1287056 1288165 R protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase complement(1287056..1288165) Corynebacterium diphtheriae NCTC 13129 2649833 NP_939633.1 CDS DIP1281 NC_002935.2 1288281 1289999 R Similar to Mycobacterium tuberculosis hypothetical 49.8 kDa protein Rv1477 or MT1524 or MTV007.24 SWALL:O53168 (EMBL:AL021184) (472 aa) fasta scores: E(): 3.5e-21, 31.88% id in 577 aa, and C-terminal half similar to the whole length of Mycobacterium tuberculosis hypothetical invasion protein Inv1 SWALL:O33171 (EMBL:AF006054) (277 aa) fasta scores: E(): 1e-17, 39.5% id in 281 aa. Note: Contains two possible colied-coil region at residues 102..130 and 182..360; invasion protein complement(1288281..1289999) Corynebacterium diphtheriae NCTC 13129 2649834 NP_939634.1 CDS DIP1282 NC_002935.2 1290514 1290717 D Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 1290514..1290717 Corynebacterium diphtheriae NCTC 13129 2649835 NP_939635.2 CDS acnA NC_002935.2 1290749 1293565 D Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 1290749..1293565 Corynebacterium diphtheriae NCTC 13129 2649836 NP_939636.1 CDS DIP1284 NC_002935.2 1293673 1294245 D Similar to Mycobacterium tuberculosis CDC1551 transcriptional regulator, TetR family MT1521 SWALL:AAK45786 (EMBL:AE007021) (187 aa) fasta scores: E(): 1.8e-40, 60.42% id in 187 aa, and to Deinococcus radiodurans transcriptional regulator, TetR family DR2148 SWALL:Q9RSH6 (EMBL:AE002049) (204 aa) fasta scores: E(): 9e-06, 30.48% id in 164 aa; TetR family transcriptional regulator 1293673..1294245 Corynebacterium diphtheriae NCTC 13129 2649837 NP_939637.1 CDS DIP1285 NC_002935.2 1294271 1294999 D Catalyzes the transfer of the ammonia group from glutamine to a new carbon-nitrogen group; glutamine amidotransferase 1294271..1294999 Corynebacterium diphtheriae NCTC 13129 2649838 NP_939638.1 CDS DIP1286 NC_002935.2 1295088 1295357 D ACT domain-containing protein; hypothetical protein 1295088..1295357 Corynebacterium diphtheriae NCTC 13129 2649839 NP_939639.1 CDS DIP1287 NC_002935.2 1295374 1296738 D Similar to Streptococcus pneumoniae hypothetical protein SP0239 SWALL:AAK74419 (EMBL:AE007336) (445 aa) fasta scores: E(): 8e-101, 65.91% id in 446 aa, and to Neisseria meningitidis hypothetical protein NMA1908 SWALL:Q9JTA4 (EMBL:AL162757) (451 aa) fasta scores: E(): 4.7e-98, 62.1% id in 446 aa; hypothetical protein 1295374..1296738 Corynebacterium diphtheriae NCTC 13129 2649840 NP_939640.1 CDS DIP1288 NC_002935.2 1296797 1297045 R Similar to Bacillus subtilis hypothetical YxlE SWALL:P94373 (EMBL:D83026) (62 aa) fasta scores: E(): 0.028, 31.03% id in 58 aa; hypothetical protein complement(1296797..1297045) Corynebacterium diphtheriae NCTC 13129 2649841 NP_939641.1 CDS DIP1289 NC_002935.2 1297069 1298700 R Similar to Mycobacterium tuberculosis CDC1551 ABC transporter, ATP-binding protein MT1519 SWALL:AAK45784 (EMBL:AE007021) (542 aa) fasta scores: E(): 2.2e-114, 70.95% id in 544 aa, and to Bacillus halodurans ABC transporter BH2025 SWALL:Q9KBA3 (EMBL:AP001514) (539 aa) fasta scores: E(): 6.5e-33, 32.07% id in 505 aa; ABC transporter ATP-binding protein complement(1297069..1298700) Corynebacterium diphtheriae NCTC 13129 2649842 NP_939642.1 CDS DIP1290 NC_002935.2 1298797 1299225 R Similar to Mycobacterium tuberculosis hypothetical 12.4 kDa protein Rv1466 or MTV007.13 SWALL:O53157 (EMBL:AL021184) (115 aa) fasta scores: E(): 6.7e-24, 67.3% id in 104 aa, and to Deinococcus radiodurans conserved hypothetical protein DR2165 SWALL:Q9RSF9 (EMBL:AE002050) (149 aa) fasta scores: E(): 1.1e-13, 43.59% id in 117 aa; hypothetical protein complement(1298797..1299225) Corynebacterium diphtheriae NCTC 13129 2649843 NP_939643.1 CDS DIP1291 NC_002935.2 1299222 1299671 R Similar to Mycobacterium tuberculosis CDC1551 nitrogen fixation protein NifU-related protein MT1512 SWALL:AAK45776 (EMBL:AE007020) (162 aa) fasta scores: E(): 2.6e-35, 63.69% id in 146 aa, and to Bacillus subtilis NifU-like protein NifU SWALL:NIFU_BACSU (SWALL:O32163) (147 aa) fasta scores: E(): 3.7e-18, 44.21% id in 147 aa; nitrogen fixation protein NifU-like protein complement(1299222..1299671) Corynebacterium diphtheriae NCTC 13129 2649844 NP_939644.1 CDS csd NC_002935.2 1299675 1300955 R Similar to Mycobacterium tuberculosis probable cysteine desulfurase Csd or Rv1464 or MT1511 or MTV007.11 SWALL:CSD_MYCTU (SWALL:O53155) (417 aa) fasta scores: E(): 1.4e-99, 63.81% id in 409 aa, and to Escherichia coli selenocysteine lyase CsdB or SufS or B1680 SWALL:CSDB_ECOLI (SWALL:P77444) (406 aa) fasta scores: E(): 1.4e-63, 41.7% id in 410 aa; cysteine desulfurase complement(1299675..1300955) Corynebacterium diphtheriae NCTC 13129 2649845 NP_939645.1 CDS DIP1293 NC_002935.2 1300955 1301713 R Similar to Streptomyces coelicolor ABC transporter ATP-binding subunit SCC22.04c SWALL:Q9XAD4 (EMBL:AL096839) (254 aa) fasta scores: E(): 4.3e-58, 70.4% id in 250 aa, and to Mycobacterium tuberculosis hypothetical 28.8 kDa protein Rv1463 or MTV007.10 SWALL:O53154 (EMBL:AL021184) (266 aa) fasta scores: E(): 8.8e-59, 70% id in 250 aa, and to Staphylococcus aureus (strain N315) SA0774 protein or SAV0842 SWALL:BAB57004 (EMBL:AP003131) (253 aa) fasta scores: E(): 1.7e-44, 58.63% id in 249 aa; ABC transporter ATP-binding protein complement(1300955..1301713) Corynebacterium diphtheriae NCTC 13129 2649846 NP_939646.1 CDS DIP1294 NC_002935.2 1301742 1302917 R Similar to Mycobacterium tuberculosis hypothetical 42.5 kDa protein Rv1462 or MT1509 or MTV007.09 SWALL:YE62_MYCTU (SWALL:O53153) (397 aa) fasta scores: E(): 7.7e-84, 56.05% id in 380 aa, and to Streptomyces coelicolor conserved hypothetical protein SCC22.06c SWALL:Q9XAD2 (EMBL:AL096839) (394 aa) fasta scores: E(): 6.1e-75, 52.86% id in 367 aa; hypothetical protein complement(1301742..1302917) Corynebacterium diphtheriae NCTC 13129 2649847 NP_939647.1 CDS DIP1295 NC_002935.2 1302920 1304299 R Similar to Streptomyces coelicolor conserved hypothetical protein SCC22.07c SWALL:Q9XAD1 (EMBL:AL096839) (473 aa) fasta scores: E(): 1.9e-154, 82.78% id in 459 aa, and to Staphylococcus aureus (strain N315) hypothetical protein SA0778 or SAV0846 SWALL:Q99VF9 (EMBL:AP003131) (465 aa) fasta scores: E(): 1.7e-123, 65.14% id in 459 aa; hypothetical protein complement(1302920..1304299) Corynebacterium diphtheriae NCTC 13129 2649848 NP_939648.1 CDS DIP1296 NC_002935.2 1304371 1305087 R Similar to Mycobacterium tuberculosis hypothetical 29.2 kDa protein Rv1460 or MTV007.07 SWALL:O53151 (EMBL:AL021184) (278 aa) fasta scores: E(): 3.4e-38, 46.25% id in 240 aa, and to Streptomyces coelicolor DNA-binding protein scc22.08C SWALL:Q9XAD0 (EMBL:AL096839) (252 aa) fasta scores: E(): 9e-27, 42.35% id in 229 aa; DNA-binding protein complement(1304371..1305087) Corynebacterium diphtheriae NCTC 13129 2649849 NP_939649.1 CDS DIP1296A NC_002935.2 1305304 1305666 R hypothetical protein complement(1305304..1305666) Corynebacterium diphtheriae NCTC 13129 2649850 NP_939650.1 CDS DIP1297 NC_002935.2 1305862 1307424 D Similar to Mycobacterium tuberculosis hypothetical 62.7 kDa protein Rv1459c or MT1506 or MTV007.06c SWALL:AAK45770 (EMBL:AL021184) (591 aa) fasta scores: E(): 2.6e-33, 36.63% id in 546 aa, and to Mycobacterium tuberculosis membrane protein Rv2174 or MT2230 or MTV021.07 SWALL:O53508 (EMBL:AL021957) (516 aa) fasta scores: E(): 2.1e-18, 30.6% id in 464 aa, and low similarity to Rhizobium meliloti cytochrome C oxidase polypeptide I transmembrane protein CtaD or R00905 or SMC00010 SWALL:Q92RG9 (EMBL:AL591785) (562 aa) fasta scores: E(): 1.6, 22.94% id in 475 aa; hypothetical protein 1305862..1307424 Corynebacterium diphtheriae NCTC 13129 2649851 NP_939651.1 CDS DIP1298 NC_002935.2 1307491 1308402 D Similar to Mycobacterium tuberculosis ABC-transporter ATP-binding protein Rv1458c or MTV007.05c SWALL:O53149 (EMBL:AL021184) (313 aa) fasta scores: E(): 2e-48, 50.32% id in 304 aa, and to Streptomyces peucetius daunorubicin resistance ATP-binding protein DrrA SWALL:DRRA_STRPE (SWALL:P32010) (330 aa) fasta scores: E(): 1.5e-24, 34.09% id in 305 aa; ABC transporter ATP-binding protein 1307491..1308402 Corynebacterium diphtheriae NCTC 13129 2649852 NP_939652.1 CDS DIP1299 NC_002935.2 1308405 1309202 D Similar to Mycobacterium tuberculosis hypothetical 27.4 kDa protein Rv1457c or MTV007.04c SWALL:O86349 (EMBL:AL021184) (261 aa) fasta scores: E(): 1.5e-31, 41.47% id in 258 aa, and to Mycobacterium smegmatis hypothetical 24.4 kDa protein SWALL:O87317 (EMBL:AF027770) (236 aa) fasta scores: E(): 1.1e-23, 37.55% id in 237 aa; hypothetical protein 1308405..1309202 Corynebacterium diphtheriae NCTC 13129 2649853 NP_939653.1 CDS DIP1300 NC_002935.2 1309283 1310221 D Similar to Mycobacterium tuberculosis hypothetical 32.4 kDa protein Rv1456c or MT1503 or MTV007.03C SWALL:AAK45767 (EMBL:AL021184) (311 aa) fasta scores: E(): 3.7e-43, 43.75% id in 304 aa, and to Streptomyces coelicolor integral membrane transport protein SCC22.12 SWALL:Q9XAC6 (EMBL:AL096839) (356 aa) fasta scores: E(): 6.9e-24, 33.01% id in 312 aa, and low similarity to Bacillus firmus cytochrome aa3 controlling protein ctaA SWALL:CTAA_BACFI (SWALL:Q04443) (297 aa) fasta scores: E(): 0.0021, 21.42% id in 266 aa; hypothetical protein 1309283..1310221 Corynebacterium diphtheriae NCTC 13129 2649854 NP_939654.1 CDS DIP1301 NC_002935.2 1310339 1311271 R converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase complement(1310339..1311271) Corynebacterium diphtheriae NCTC 13129 2649855 NP_939655.1 CDS tkt NC_002935.2 1311649 1313751 D catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 1311649..1313751 Corynebacterium diphtheriae NCTC 13129 2649856 NP_939656.1 CDS tal NC_002935.2 1313875 1314957 D catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate; transaldolase 1313875..1314957 Corynebacterium diphtheriae NCTC 13129 2649857 NP_939657.1 CDS zwf NC_002935.2 1315019 1316668 D catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 1315019..1316668 Corynebacterium diphtheriae NCTC 13129 2649858 NP_939658.1 CDS DIP1305 NC_002935.2 1316693 1317652 D Similar to Streptomyces coelicolor hypothetical 37.7 kDa protein SCC22.20 SWALL:Q9XAB8 (EMBL:AL096839) (351 aa) fasta scores: E(): 1.5e-36, 41.82% id in 318 aa, and to Mycobacterium tuberculosis hypothetical 32.7 kDa protein OpcA or Rv1446c or MT1493 or MTCY493.08 SWALL:AAK45756 (EMBL:Z95844) (303 aa) fasta scores: E(): 9.5e-35, 39.3% id in 318 aa; hypothetical protein 1316693..1317652 Corynebacterium diphtheriae NCTC 13129 2649859 NP_939659.1 CDS DIP1306 NC_002935.2 1317678 1318394 D catalyzes the formation of 6-phospho-D-gluconate from 6-phospho-D-glucono-1,5-lactone; 6-phosphogluconolactonase 1317678..1318394 Corynebacterium diphtheriae NCTC 13129 2649860 NP_939660.1 CDS secG NC_002935.2 1318462 1318695 R Similar to Corynebacterium glutamicum protein-export membrane protein SecG SWALL:SECG_CORGL (SWALL:Q9Z469) (77 aa) fasta scores: E(): 7.3e-22, 82.89% id in 76 aa, and to Escherichia coli protein-export membrane protein SecG or B3175 or Z4537 or ECS4054 SWALL:SECG_ECOLI (SWALL:P33582) (110 aa) fasta scores: E(): 0.55, 26.02% id in 73 aa; preprotein translocase subunit SecG complement(1318462..1318695) Corynebacterium diphtheriae NCTC 13129 2649861 NP_939661.1 CDS tpiA NC_002935.2 1318869 1319651 R Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase complement(1318869..1319651) Corynebacterium diphtheriae NCTC 13129 2649862 NP_939662.1 CDS pgk NC_002935.2 1319763 1320980 R Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase complement(1319763..1320980) Corynebacterium diphtheriae NCTC 13129 2649863 NP_939663.1 CDS gap NC_002935.2 1321111 1322115 R catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; glyceraldehyde-3-phosphate dehydrogenase complement(1321111..1322115) Corynebacterium diphtheriae NCTC 13129 2649864 NP_939664.1 CDS DIP1311 NC_002935.2 1322488 1323474 R Similar to Mycobacterium tuberculosis hypothetical 34.9 kDa protein CY21B4.41 Rv1423 or MT1466 or MTCY21B4.41 or MTCY493.31c SWALL:AAK45731 (EMBL:Z80108) (327 aa) fasta scores: E(): 4.2e-71, 61.84% id in 325 aa, and to Streptomyces coelicolor WhiA SWALL:Q9S4Y1 (EMBL:AF106003) (330 aa) fasta scores: E(): 3.7e-67, 57.53% id in 325 aa; hypothetical protein complement(1322488..1323474) Corynebacterium diphtheriae NCTC 13129 2649865 NP_939665.1 CDS DIP1312 NC_002935.2 1323568 1324539 R Similar to Mycobacterium leprae hypothetical protein ML0564 SWALL:Q9CCN9 (EMBL:AL583918) (359 aa) fasta scores: E(): 2.7e-63, 57.6% id in 309 aa, and to Escherichia coli hypothetical protein YbhK or B0780 SWALL:YBHK_ECOLI (SWALL:P75767) (302 aa) fasta scores: E(): 1.5e-11, 31.95% id in 291 aa; hypothetical protein complement(1323568..1324539) Corynebacterium diphtheriae NCTC 13129 2649866 NP_939666.1 CDS DIP1313 NC_002935.2 1324558 1325457 R Similar to Mycobacterium tuberculosis hypothetical 32.9 kDa protein Rv1421 or MT1464 or MTCY21B4.39 SWALL:YE21_MYCTU (SWALL:P71690) (301 aa) fasta scores: E(): 9e-52, 47.82% id in 299 aa, and to Clostridium acetobutylicum predicted P-loop containing kinase, similar to B.subtilis YvcJ CAC0511 SWALL:AAK78491 (EMBL:AE007566) (294 aa) fasta scores: E(): 4.8e-43, 44.21% id in 285 aa; hypothetical protein complement(1324558..1325457) Corynebacterium diphtheriae NCTC 13129 2649867 NP_939667.1 CDS uvrC NC_002935.2 1325463 1327526 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C complement(1325463..1327526) Corynebacterium diphtheriae NCTC 13129 2649868 NP_939668.1 CDS DIP1315 NC_002935.2 1327536 1328096 R Similar to Corynebacterium ammoniagenes RibX protein SWALL:O24754 (EMBL:AB003693) (184 aa) fasta scores: E(): 1.3e-34, 45.98% id in 187 aa, and to Mycobacterium leprae membrane protein ML0561 SWALL:Q9CCP2 (EMBL:AL583918) (156 aa) fasta scores: E(): 2.3e-15, 37.58% id in 141 aa; hypothetical protein complement(1327536..1328096) Corynebacterium diphtheriae NCTC 13129 2649869 NP_939669.1 CDS ribH NC_002935.2 1328235 1328702 R RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase complement(1328235..1328702) Corynebacterium diphtheriae NCTC 13129 2649870 NP_939670.1 CDS ribA NC_002935.2 1328703 1329941 R bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate; bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II complement(1328703..1329941) Corynebacterium diphtheriae NCTC 13129 2649871 NP_939671.1 CDS ribE NC_002935.2 1330056 1330664 R catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha complement(1330056..1330664) Corynebacterium diphtheriae NCTC 13129 2649872 NP_939672.1 CDS ribD NC_002935.2 1330722 1331726 R Similar to Corynebacterium ammoniagenes riboflavin biosynthesis protein [includes: riboflavin-specific deaminase and uracil reductase] RibD or RibG SWALL:RIBD_CORAM (SWALL:O24750) (337 aa) fasta scores: E(): 4.7e-50, 46.89% id in 322 aa, and to Bacillus subtilis riboflavin biosynthesis protein RibD or RibG SWALL:RIBD_BACSU (SWALL:P17618) (361 aa) fasta scores: E(): 2.8e-22, 34.76% id in 325 aa; riboflavin biosynthesis protein complement(1330722..1331726) Corynebacterium diphtheriae NCTC 13129 2649873 NP_939673.1 CDS rpe NC_002935.2 1331821 1332495 R catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase complement(1331821..1332495) Corynebacterium diphtheriae NCTC 13129 2649874 NP_939674.1 CDS DIP1321 NC_002935.2 1332549 1334006 R Similar to Mycobacterium tuberculosis hypothetical 48.5 kDa protein Rv1407 or MT1451 or MTCY21B4.24 SWALL:YE07_MYCTU (SWALL:P71675) (457 aa) fasta scores: E(): 6.2e-86, 55.4% id in 453 aa, and to Escherichia coli Sun protein Sun or Fmu or Fmv or RsmB or B3289 SWALL:SUN_ECOLI (SWALL:P36929) (429 aa) fasta scores: E(): 1.2e-31, 33.63% id in 449 aa; hypothetical protein complement(1332549..1334006) Corynebacterium diphtheriae NCTC 13129 2649875 NP_939675.1 CDS fmt NC_002935.2 1334003 1334938 R modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase complement(1334003..1334938) Corynebacterium diphtheriae NCTC 13129 2649876 NP_939676.1 CDS def NC_002935.2 1334975 1335484 R cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase complement(1334975..1335484) Corynebacterium diphtheriae NCTC 13129 2649877 NP_939677.1 CDS DIP1324 NC_002935.2 1335564 1337591 R binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA complement(1335564..1337591) Corynebacterium diphtheriae NCTC 13129 2649878 NP_939678.1 CDS metK NC_002935.2 1337610 1338842 R methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase complement(1337610..1338842) Corynebacterium diphtheriae NCTC 13129 2649879 NP_939679.1 CDS dfp NC_002935.2 1338983 1340227 R catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase complement(1338983..1340227) Corynebacterium diphtheriae NCTC 13129 2649880 NP_939680.1 CDS rpoZ NC_002935.2 1340329 1340607 R Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega complement(1340329..1340607) Corynebacterium diphtheriae NCTC 13129 2649881 NP_939681.1 CDS gmk NC_002935.2 1340681 1341256 R Essential for recycling GMP and indirectly, cGMP; guanylate kinase complement(1340681..1341256) Corynebacterium diphtheriae NCTC 13129 2649882 NP_939682.1 CDS mihF NC_002935.2 1341260 1341583 R Similar to Mycobacterium smegmatis integration host factor MihF SWALL:P96802 (EMBL:U75344) (105 aa) fasta scores: E(): 7.1e-21, 72.38% id in 105 aa, and to Mycobacterium tuberculosis hypothetical 20.8 kDa protein CY21B4.05 Rv1388 or MT1433 or MTCY21B4.05 SWALL:AAK45698 (EMBL:Z80108) (111 aa) fasta scores: E(): 3.8e-21, 74.75% id in 103 aa; integration host factor complement(1341260..1341583) Corynebacterium diphtheriae NCTC 13129 2649883 NP_939683.1 CDS pyrF NC_002935.2 1341932 1342780 R OMP decarboxylase; OMPDCase; OMPdecase; type 2 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase complement(1341932..1342780) Corynebacterium diphtheriae NCTC 13129 2649884 NP_939684.1 CDS carB NC_002935.2 1342777 1346133 R four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit complement(1342777..1346133) Corynebacterium diphtheriae NCTC 13129 2649885 NP_939685.1 CDS carA NC_002935.2 1346154 1347293 R catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit complement(1346154..1347293) Corynebacterium diphtheriae NCTC 13129 2649886 NP_939686.1 CDS pyrC NC_002935.2 1347449 1348795 R catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase complement(1347449..1348795) Corynebacterium diphtheriae NCTC 13129 2649887 NP_939687.1 CDS pyrB NC_002935.2 1348820 1349761 R catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase complement(1348820..1349761) Corynebacterium diphtheriae NCTC 13129 2648777 NP_939688.1 CDS pyrR NC_002935.2 1349761 1350333 R regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase complement(1349761..1350333) Corynebacterium diphtheriae NCTC 13129 2648778 NP_939689.1 CDS DIP1336 NC_002935.2 1350598 1351959 D C-terminal region similar to Mycobacterium tuberculosis hypothetical 31.7 kDa protein Rv2216 or MT2273 or MTCY190.27 SWALL:YM16_MYCTU (SWALL:Q10403) (301 aa) fasta scores: E(): 4e-32, 36.51% id in 293 aa, and N-terminal region to Bacillus halodurans BH1480 protein SWALL:Q9KCT9 (EMBL:AP001512) (144 aa) fasta scores: E(): 0.047, 27.35% id in 106 aa; hypothetical protein 1350598..1351959 Corynebacterium diphtheriae NCTC 13129 2648779 NP_939690.1 CDS DIP1337 NC_002935.2 1351965 1352402 D hypothetical protein 1351965..1352402 Corynebacterium diphtheriae NCTC 13129 2648780 NP_939691.1 CDS DIP1338 NC_002935.2 1352402 1352812 D hypothetical protein 1352402..1352812 Corynebacterium diphtheriae NCTC 13129 2648781 NP_939692.1 CDS nusB NC_002935.2 1352866 1353414 R Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB complement(1352866..1353414) Corynebacterium diphtheriae NCTC 13129 2648782 NP_939693.1 CDS efp NC_002935.2 1353483 1354046 R Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P complement(1353483..1354046) Corynebacterium diphtheriae NCTC 13129 2648783 NP_939694.1 CDS DIP1341 NC_002935.2 1354148 1355245 R Similar to Mycobacterium tuberculosis hypothetical 38.8 kDa protein PepQ or Rv2535c or MTCY159.21 SWALL:P95018 (EMBL:Z83863) (372 aa) fasta scores: E(): 2.3e-52, 45.64% id in 344 aa, and to Bacillus halodurans xaa-pro dipeptidase BH2800 SWALL:Q9K950 (EMBL:AP001516) (355 aa) fasta scores: E(): 1.2e-43, 41.57% id in 356 aa; metallopeptidase complement(1354148..1355245) Corynebacterium diphtheriae NCTC 13129 2648784 NP_939695.1 CDS aroQ NC_002935.2 1355271 1355711 R catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis; 3-dehydroquinate dehydratase complement(1355271..1355711) Corynebacterium diphtheriae NCTC 13129 2648785 NP_939696.1 CDS aroB NC_002935.2 1355712 1356791 R catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase complement(1355712..1356791) Corynebacterium diphtheriae NCTC 13129 2648786 NP_939697.1 CDS aroK NC_002935.2 1356838 1357359 R catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase complement(1356838..1357359) Corynebacterium diphtheriae NCTC 13129 2648787 NP_939698.1 CDS aroC NC_002935.2 1357394 1358605 R catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase complement(1357394..1358605) Corynebacterium diphtheriae NCTC 13129 2648788 NP_939699.1 CDS DIP1346 NC_002935.2 1358683 >1359189 R Similar to the C-terminal region of Aeromonas salmonicida type 4 prepilin-like proteins leader peptide processing enzyme [includes: leader peptidase TapD or PilD] SWALL:LEP4_AERSA (SWALL:O68964) (291 aa) fasta scores: E(): 0.012, 26.71% id in 146 aa; hypothetical protein complement(1358683..>1359189) Corynebacterium diphtheriae NCTC 13129 2648789 NP_939700.1 CDS aroE NC_002935.2 1359196 1360065 R AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase complement(1359196..1360065) Corynebacterium diphtheriae NCTC 13129 2648790 NP_939701.1 CDS DIP1348 NC_002935.2 1360160 1361308 R Similar to, although shorter in its N-terminal region than Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT2630 SWALL:AAK46942 (EMBL:AE007097) (417 aa) fasta scores: E(): 2.3e-52, 41.38% id in 389 aa, and similar to Haemophilus influenzae hypothetical protein HI0457 SWALL:YCEG_HAEIN (SWALL:P44720) (347 aa) fasta scores: E(): 7.2e-14, 28.76% id in 365 aa; hypothetical protein complement(1360160..1361308) Corynebacterium diphtheriae NCTC 13129 2648791 NP_939702.1 CDS DIP1349 NC_002935.2 1361421 1361972 R similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein complement(1361421..1361972) Corynebacterium diphtheriae NCTC 13129 2648792 NP_939703.1 CDS alaS NC_002935.2 1362202 1364868 R Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase complement(1362202..1364868) Corynebacterium diphtheriae NCTC 13129 2648793 NP_939704.1 CDS DIP1351 NC_002935.2 1365030 1366400 R Similar to Mycobacterium tuberculosis hypothetical 47.5 kDa protein Rv2559c or MT2636 or MTCY9C4.09 SWALL:YP59_MYCTU (SWALL:Q50739) (452 aa) fasta scores: E(): 3.1e-95, 66.59% id in 455 aa, and to Streptomyces coelicolor conserved ATP/GTP binding protein SC9C5.30c SWALL:Q9KXP4 (EMBL:AL357523) (451 aa) fasta scores: E(): 4.3e-84, 63.52% id in 414 aa; recombination factor protein RarA complement(1365030..1366400) Corynebacterium diphtheriae NCTC 13129 2648794 NP_939705.1 CDS DIP1352 NC_002935.2 1366425 1367687 R hypothetical protein complement(1366425..1367687) Corynebacterium diphtheriae NCTC 13129 2648795 NP_939706.1 CDS aspS NC_002935.2 1367810 1369615 R catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase complement(1367810..1369615) Corynebacterium diphtheriae NCTC 13129 2648796 NP_939707.1 CDS DIP1354 NC_002935.2 1369837 1370721 D Similar to Mycobacterium tuberculosis hypothetical 30.8 kDa protein Rv2575 or MT2651 or MTCY227.26c SWALL:YP75_MYCTU (SWALL:Q50646) (293 aa) fasta scores: E(): 1.8e-45, 44.74% id in 295 aa, and to Agrobacterium tumefaciens strC58 AGR_C_3948p SWALL:AAK87920 (EMBL:AE008134) (305 aa) fasta scores: E(): 1.1e-31, 36.66% id in 300 aa; hypothetical protein 1369837..1370721 Corynebacterium diphtheriae NCTC 13129 2648797 NP_939708.1 CDS DIP1355 NC_002935.2 1370802 1373456 R Similar to Streptomyces coelicolor bifunctional protein SCBAC20F6.07 SWALL:Q9ADE3 (EMBL:AL590942) (800 aa) fasta scores: E(): 5e-37, 39% id in 700 aa, and to Streptomyces griseus hypothetical 77.7 kDa protein SWALL:BAB64333 (EMBL:AB056583) (724 aa) fasta scores: E(): 2.5e-32, 34.85% id in 680 aa; hypothetical protein complement(1370802..1373456) Corynebacterium diphtheriae NCTC 13129 2648798 NP_939709.1 CDS DIP1356 NC_002935.2 1373535 1375556 R Similar to Bacillus subtilis hypothetical 84.1 kDa protein in hemY-gltT intergenic region YhgE SWALL:YHGE_BACSU (SWALL:P32399) (775 aa) fasta scores: E(): 5.1e-22, 25.23% id in 761 aa, and to Lactococcus lactis hypothetical protein YjaE or LL0882 SWALL:Q9CH57 (EMBL:AE006322) (799 aa) fasta scores: E(): 6.5e-20, 24.68% id in 790 aa; hypothetical protein complement(1373535..1375556) Corynebacterium diphtheriae NCTC 13129 2648799 NP_939710.1 CDS DIP1357 NC_002935.2 1375574 1376308 R hypothetical protein complement(1375574..1376308) Corynebacterium diphtheriae NCTC 13129 2649888 NP_939711.1 CDS DIP1358 NC_002935.2 1376471 1377061 D Similar to Streptomyces coelicolor TetR family transcriptional regulator SCF6.16 SWALL:Q9RJL5 (EMBL:AL121849) (194 aa) fasta scores: E(): 6.8e-06, 25.53% id in 188 aa, and to Rhizobium loti probable transcription regulator MLL1924 SWALL:Q98JI8 (EMBL:AP002998) (205 aa) fasta scores: E(): 1.1e-05, 25.77% id in 194 aa; TetR family transcriptional regulator 1376471..1377061 Corynebacterium diphtheriae NCTC 13129 2649889 NP_939712.1 CDS sdaB NC_002935.2 1377106 1378494 D Similar to Pseudomonas aeruginosa L-serine dehydratase SdaB or PA5379 SWALL:Q9HTI5 (EMBL:AE004950) (458 aa) fasta scores: E(): 3.5e-84, 53.99% id in 463 aa, and to Escherichia coli L-serine dehydratase 1 SdaA or B1814 SWALL:SDHL_ECOLI (SWALL:P16095) (454 aa) fasta scores: E(): 3e-70, 49.24% id in 461 aa; L-serine dehydratase 1377106..1378494 Corynebacterium diphtheriae NCTC 13129 2649890 NP_939713.1 CDS hisS NC_002935.2 1378566 1379837 R catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase complement(1378566..1379837) Corynebacterium diphtheriae NCTC 13129 2649891 NP_939714.1 CDS DIP1361 NC_002935.2 1379878 1380534 R Similar to Streptomyces coelicolor possible hydrolase SC9C5.33c SWALL:Q9KXP1 (EMBL:AL357523) (235 aa) fasta scores: E(): 6.5e-25, 40.35% id in 223 aa, and to Escherichia coli hypothetical protein YcbL or B0927 SWALL:YCBL_ECOLI (SWALL:P75849) (215 aa) fasta scores: E(): 3.7e-23, 36.79% id in 212 aa; hypothetical protein complement(1379878..1380534) Corynebacterium diphtheriae NCTC 13129 2649892 NP_939715.1 CDS tpx NC_002935.2 1380544 1381041 R Similar to Escherichia coli thiol peroxidase Tpx or B1324 or Z2452 or ECS1903 SWALL:TPX_ECOLI (SWALL:P37901) (167 aa) fasta scores: E(): 5.8e-35, 61.11% id in 162 aa, and to Pseudomonas aeruginosa probable thiol peroxidase Tpx or PA2532 SWALL:TPX_PSEAE (SWALL:P57668) (165 aa) fasta scores: E(): 4.8e-32, 55.75% id in 165 aa; thiol peroxidase complement(1380544..1381041) Corynebacterium diphtheriae NCTC 13129 2649893 NP_939716.1 CDS DIP1363 NC_002935.2 1381185 1382027 D Similar to Mycobacterium tuberculosis probable peptidyl-prolyl cis-trans isomerase B PpiB or Ppi or Rv2582 or MT2659 or MTCY227.19c SWALL:PPIB_MYCTU (SWALL:Q50639) (308 aa) fasta scores: E(): 5.5e-37, 46.23% id in 292 aa, and to Streptomyces coelicolor peptidyl-prolyl cis-trans isomerase SC9C5.34 SWALL:Q9KXP0 (EMBL:AL357523) (277 aa) fasta scores: E(): 3.5e-26, 37.5% id in 288 aa; isomerase 1381185..1382027 Corynebacterium diphtheriae NCTC 13129 2649894 NP_939717.1 CDS DIP1364 NC_002935.2 1382185 1382466 D hypothetical protein 1382185..1382466 Corynebacterium diphtheriae NCTC 13129 2649895 NP_939718.1 CDS DIP1365 NC_002935.2 1382517 1382657 D Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 1382517..1382657 Corynebacterium diphtheriae NCTC 13129 2649896 NP_939719.1 CDS DIP1366 NC_002935.2 1382700 1384079 D Similar to, although shorter than Escherichia coli possible transposase of IS1353 YahA SWALL:Q9WTH9 (EMBL:AP000342) (514 aa) fasta scores: E(): 1.4e-62, 41.59% id in 464 aa, and similar in its C-terminal region to Escherichia coli transposase InsK for insertion sequence element IS150 InsK or B3558 SWALL:INSK_ECOLI (SWALL:P19769) (283 aa) fasta scores: E(): 1.4e-35, 38.98% id in 277 aa; transposase 1382700..1384079 Corynebacterium diphtheriae NCTC 13129 2649897 NP_939720.1 CDS relA NC_002935.2 1384750 1387029 R Similar to Corynebacterium glutamicum GTP pyrophosphokinase RelA or Rel SWALL:RELA_CORGL (SWALL:O87331) (760 aa) fasta scores: E(): 0, 86.05% id in 760 aa, and to Escherichia coli GTP pyrophosphokinase RelA or B2784 or Z4099 or ECS3644 SWALL:RELA_ECOLI (SWALL:P11585) (744 aa) fasta scores: E(): 4.1e-97, 36.54% id in 684 aa, and to Streptomyces coelicolor GTP pyrophosphokinase RelA or SCL2.03c SWALL:RELA_STRCO (SWALL:P52560) (847 aa) fasta scores: E(): 7.3e-90, 58.33% id in 768 aa; GTP pyrophosphokinase complement(1384750..1387029) Corynebacterium diphtheriae NCTC 13129 2649899 NP_939721.1 CDS apt NC_002935.2 1387088 1387642 R catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase complement(1387088..1387642) Corynebacterium diphtheriae NCTC 13129 2649900 NP_939722.1 CDS DIP1370 NC_002935.2 1387698 1389449 R Similar to Corynebacterium glutamicum dipeptide-binding protein DciaE SWALL:O87329 (EMBL:AF038651) (502 aa) fasta scores: E(): 4e-83, 48.61% id in 434 aa, and to Mycobacterium tuberculosis hypothetical lipoprotein Rv2585c precursor or MT2662 or MTCY227.16 SWALL:YP85_MYCTU (SWALL:Q50636) (557 aa) fasta scores: E(): 7.1e-30, 29.09% id in 574 aa; hypothetical protein complement(1387698..1389449) Corynebacterium diphtheriae NCTC 13129 2649901 NP_939723.1 CDS secF NC_002935.2 1389519 1390631 R forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF complement(1389519..1390631) Corynebacterium diphtheriae NCTC 13129 2649902 NP_939724.1 CDS secD NC_002935.2 1390632 1392410 R part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD complement(1390632..1392410) Corynebacterium diphtheriae NCTC 13129 2649903 NP_939725.1 CDS DIP1373 NC_002935.2 1392415 1392600 R hypothetical protein complement(1392415..1392600) Corynebacterium diphtheriae NCTC 13129 2649904 NP_939726.1 CDS DIP1374 NC_002935.2 1392641 1392934 R Similar to Corynebacterium glutamicum hypothetical 13.5 kDa protein SWALL:Q9AE08 (EMBL:AF038651) (121 aa) fasta scores: E(): 7.2e-10, 34.83% id in 89 aa, and to Mycobacterium tuberculosis hypothetical 13.0 kDa protein Rv2588c precursor or MT2665 or MTCY227.13 SWALL:YP88_MYCTU (SWALL:Q50633) (115 aa) fasta scores: E(): 5.9e-05, 37.77% id in 90 aa; hypothetical protein complement(1392641..1392934) Corynebacterium diphtheriae NCTC 13129 2649905 NP_939727.1 CDS ruvB NC_002935.2 1392938 1394026 R promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB complement(1392938..1394026) Corynebacterium diphtheriae NCTC 13129 2649906 NP_939728.1 CDS ruvA NC_002935.2 1394044 1394655 R plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA complement(1394044..1394655) Corynebacterium diphtheriae NCTC 13129 2649907 NP_939729.1 CDS ruvC NC_002935.2 1394694 1395185 R endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase complement(1394694..1395185) Corynebacterium diphtheriae NCTC 13129 2649908 NP_939730.1 CDS yfcA NC_002935.2 1395368 1396120 R Highly similar to Corynebacterium glutamicum hypothetical structural protein YfcA SWALL:Q9AE12 (EMBL:AF038651) (251 aa) fasta scores: E(): 2.7e-76, 83.53% id in 249 aa, and to Escherichia coli protein YebC in 249 aa; hypothetical protein complement(1395368..1396120) Corynebacterium diphtheriae NCTC 13129 2649909 NP_939731.1 CDS tesB NC_002935.2 1396358 1397212 R Similar to Mycobacterium tuberculosis TesB or TesB2 or Rv2605c or MTCY01A10.28 SWALL:O06209 (EMBL:Z95387) (281 aa) fasta scores: E(): 1.9e-49, 50.17% id in 279 aa, and to Escherichia coli acyl-CoA thioesterase II TesB or B0452 or Z0564 or ECS0506 SWALL:TESB_ECOLI (SWALL:P23911) (285 aa) fasta scores: E(): 3e-20, 37.27% id in 279 aa; acyl-CoA thioesterase complement(1396358..1397212) Corynebacterium diphtheriae NCTC 13129 2649910 NP_939732.1 CDS DIP1380 NC_002935.2 1397443 1398588 D hypothetical protein 1397443..1398588 Corynebacterium diphtheriae NCTC 13129 2649911 NP_939733.1 CDS DIP1381 NC_002935.2 1398642 1399385 D catalyzes the formation of pimeloyl-CoA from pimelate and coenzyme A; 6-carboxyhexanoate--CoA ligase 1398642..1399385 Corynebacterium diphtheriae NCTC 13129 2649912 NP_939734.1 CDS DIP1382 NC_002935.2 1399385 1400575 D Similar to Bacillus sphaericus 8-amino-7-oxononanoate synthase BioF SWALL:BIOF_BACSH (SWALL:P22806) (389 aa) fasta scores: E(): 8.9e-47, 40.95% id in 376 aa, and to Escherichia coli 8-amino-7-oxononanoate synthase BioF or B0776 SWALL:BIOF_ECOLI (SWALL:P12998) (384 aa) fasta scores: E(): 9.8e-39, 37.39% id in 353 aa; aminotransferase 1399385..1400575 Corynebacterium diphtheriae NCTC 13129 2649913 NP_939735.1 CDS DIP1383 NC_002935.2 1400572 1401033 R Similar to the N-terminal region of Mycobacterium tuberculosis CDC1551 MutT/NudIX family protein MT2684 SWALL:AAK47000 (EMBL:AE007101) (351 aa) fasta scores: E(): 1.2e-06, 42.2% id in 154 aa, and to Streptomyces coelicolor hypothetical 19.8 kDa protein SCL2.14c SWALL:Q9L285 (EMBL:AL137778) (180 aa) fasta scores: E(): 0.0099, 35.88% id in 170 aa; hypothetical protein complement(1400572..1401033) Corynebacterium diphtheriae NCTC 13129 2649914 NP_939736.1 CDS DIP1384 NC_002935.2 1401045 1402136 R Similar to Streptomyces coelicolor sugar transferase SCL2.15c SWALL:Q9L284 (EMBL:AL137778) (387 aa) fasta scores: E(): 3.5e-45, 49.06% id in 375 aa, and to Mycobacterium tuberculosis CDC1551 glycosyl transferase MT2685 SWALL:AAK47001 (EMBL:AE007101) (378 aa) fasta scores: E(): 9.2e-42, 47.89% id in 380 aa; transferase (LPS related) complement(1401045..1402136) Corynebacterium diphtheriae NCTC 13129 2649915 NP_939737.1 CDS DIP1385 NC_002935.2 1402163 1403104 R Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase complement(1402163..1403104) Corynebacterium diphtheriae NCTC 13129 2649916 NP_939738.1 CDS DIP1386 NC_002935.2 1403131 1403784 R Similar to Mycobacterium tuberculosis CDC1551 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, MT2687 SWALL:AAK47003 (EMBL:AE007101) (217 aa) fasta scores: E(): 6.9e-34, 48.29% id in 205 aa, and to Mycobacterium smegmatis phosphatidylinositol synthase PgsA SWALL:Q9F7Y9 (EMBL:AF265558) (222 aa) fasta scores: E(): 8.7e-31, 47% id in 200 aa; phosphatidyltransferase complement(1403131..1403784) Corynebacterium diphtheriae NCTC 13129 2649917 NP_939739.1 CDS DIP1387 NC_002935.2 1403777 1404361 R Similar to Mycobacterium leprae hypothetical protein ML0455 SWALL:Q9CCU0 (EMBL:AL583918) (206 aa) fasta scores: E(): 6.3e-43, 61.49% id in 174 aa, and to Mycobacterium leprae hypothetical 20.7 kDa protein MLCl581.17c SWALL:O07150 (EMBL:Z96801) (186 aa) fasta scores: E(): 4.1e-42, 62.13% id in 169 aa; hypothetical protein complement(1403777..1404361) Corynebacterium diphtheriae NCTC 13129 2649918 NP_939740.1 CDS thrS NC_002935.2 1404545 1406608 R catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase complement(1404545..1406608) Corynebacterium diphtheriae NCTC 13129 2649919 NP_939741.1 CDS DIP1389 NC_002935.2 1406797 1408017 R Similar to Yersinia pestis hypothetical protein YPO1856 SWALL:Q8ZF62 (EMBL:AJ414150) (434 aa) fasta scores: E(): 8.7e-30, 33.74% id in 406 aa, and to Escherichia coli hypothetical protein YcdB precursor or B1019 SWALL:YCDB_ECOLI (SWALL:P31545) (423 aa) fasta scores: E(): 2.4e-29, 32.22% id in 419 aa. Note: Contains a twin-arginine translocation (TAT) system recognition motif (RRGFLT) at the N-terminal region; hypothetical protein complement(1406797..1408017) Corynebacterium diphtheriae NCTC 13129 2648907 NP_939742.1 CDS DIP1390 NC_002935.2 1408111 1408725 R Low similarity to Vibrio cholerae hypothetical protein VCA0037 SWALL:Q9KNC8 (EMBL:AE004347) (150 aa) fasta scores: E(): 9.6e-09, 34.09% id in 132 aa, and to Rhizobium loti MLL3326 protein SWALL:Q98GH4 (EMBL:AP003001) (179 aa) fasta scores: E(): 3.1e-05, 29.45% id in 146 aa; hypothetical protein complement(1408111..1408725) Corynebacterium diphtheriae NCTC 13129 2648908 NP_939743.1 CDS DIP1391 NC_002935.2 1408732 1409376 R hypothetical protein complement(1408732..1409376) Corynebacterium diphtheriae NCTC 13129 2649274 NP_939744.1 CDS DIP1392 NC_002935.2 1410549 1411358 D Similar to Mycobacterium leprae hypothetical 29.0 kDa protein ML1340 or MLC1351.23 TR:O05684 (EMBL:Z95117) (268 aa) fasta scores: E(): 1.4e-12, 30.97% id in 226 aa, and to Mycobacterium tuberculosis hypothetical 27.7 kDa protein CY441.40 Rv2671 or MT2745 or MTCY441.40 TR:AAK47060 (EMBL:Z80225) (239 aa) fasta scores: E(): 9.8e-12, 29.27% id in 222 aa; hypothetical protein 1410549..1411358 Corynebacterium diphtheriae NCTC 13129 2649467 NP_939745.1 CDS DIP1393 NC_002935.2 1411416 1411826 D Similar to Mycobacterium tuberculosis CDC1551 PilB-related protein MT2748 TR:AAK47063 (EMBL:AE007105) (136 aa) fasta scores: E(): 6.2e-39, 70.67% id in 133 aa, and to Streptomyces coelicolor oxidoreductase SC9B1.08 TR:Q9X828 (EMBL:AL049727) (135 aa) fasta scores: E(): 4.3e-33, 67.74% id in 124 aa; hypothetical protein 1411416..1411826 Corynebacterium diphtheriae NCTC 13129 2649468 NP_939746.1 CDS DIP1394 NC_002935.2 1411905 1412609 R Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT2750 TR:AAK47065 (EMBL:AE007105) (231 aa) fasta scores: E(): 3e-55, 59.3% id in 231 aa, and to Streptomyces coelicolor hypothetical 28.1 kDa protein Sc1B5.02 TR:O69830 (EMBL:AL023517) (243 aa) fasta scores: E(): 5.5e-48, 54.7% id in 223 aa; hypothetical protein complement(1411905..1412609) Corynebacterium diphtheriae NCTC 13129 2649469 NP_939747.1 CDS DIP1395 NC_002935.2 1412834 1413415 D Similar to Mycobacterium tuberculosis hypothetical 22.6 kDa protein Rv2680 or MT2754 or MTV010.04 TR:O86317 (EMBL:Z96072) (210 aa) fasta scores: E(): 2.7e-38, 56.59% id in 182 aa, and to Streptomyces coelicolor hypothetical 24.7 kDa protein Sc1C3.1cC TR:O69860 (EMBL:AL023702) (238 aa) fasta scores: E(): 1.2e-22, 41.17% id in 187 aa; hypothetical protein 1412834..1413415 Corynebacterium diphtheriae NCTC 13129 2649470 NP_939748.1 CDS DIP1396 NC_002935.2 1413434 1414657 D Similar to Mycobacterium tuberculosis CDC1551 ribonuclease D, MT2755 TR:AAK47070 (EMBL:AE007105) (438 aa) fasta scores: E(): 5.1e-49, 38.14% id in 409 aa, and to Escherichia coli ribonuclease D Rnd or B1804 SW:RND_ECOLI (P09155) (375 aa) fasta scores: E(): 1.2e-10, 28.36% id in 342 aa; ribonuclease 1413434..1414657 Corynebacterium diphtheriae NCTC 13129 2649471 NP_939749.1 CDS dxs NC_002935.2 1414718 1416625 R catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase complement(1414718..1416625) Corynebacterium diphtheriae NCTC 13129 2649472 NP_939750.1 CDS DIP1398 NC_002935.2 1416837 1418099 R Similar to Mycobacterium tuberculosis hypothetical 43.2 kDa protein Rv2689c or MT2763 or MTCY05A6.10c TR:O07191 (EMBL:Z96072) (405 aa) fasta scores: E(): 3.4e-27, 40.39% id in 401 aa, and to Streptomyces coelicolor SC10A5.06 protein TR:O54099 (EMBL:AL021529) (458 aa) fasta scores: E(): 1e-20, 31.59% id in 440 aa; hypothetical protein complement(1416837..1418099) Corynebacterium diphtheriae NCTC 13129 2649473 NP_939751.1 CDS DIP1399 NC_002935.2 1418417 1419136 R Similar to Mycobacterium leprae U1764K ML1029 TR:Q49993 (EMBL:U15181) (273 aa) fasta scores: E(): 1e-24, 38.88% id in 234 aa, and to Mycobacterium tuberculosis hypothetical 27.2 kDa protein Rv2696c or MTCY05A6.17c TR:O07198 (EMBL:Z96072) (259 aa) fasta scores: E(): 1.5e-24, 37.34% id in 241 aa; hypothetical protein complement(1418417..1419136) Corynebacterium diphtheriae NCTC 13129 2649474 NP_939752.1 CDS dut NC_002935.2 1419195 1419653 R catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase complement(1419195..1419653) Corynebacterium diphtheriae NCTC 13129 2649475 NP_939753.1 CDS DIP1401 NC_002935.2 1419796 1420308 D Similar to Mycobacterium tuberculosis hypothetical 17.6 kDa protein Rv2698 or MTCY05A6.19 TR:O07200 (EMBL:Z96072) (161 aa) fasta scores: E(): 1.9e-21, 45.28% id in 159 aa, and to Mycobacterium leprae U1764I ML12027 TR:Q49991 (EMBL:U15181) (157 aa) fasta scores: E(): 3e-19, 41.77% id in 158 aa; hypothetical protein 1419796..1420308 Corynebacterium diphtheriae NCTC 13129 2649476 NP_939754.1 CDS DIP1402 NC_002935.2 1420344 1420637 R Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT2773 TR:AAK47088 (EMBL:AE007106) (100 aa) fasta scores: E(): 1.6e-17, 57% id in 100 aa, and to Streptomyces coelicolor hypothetical 11.0 kDa protein SC2E9.05 TR:O54130 (EMBL:AL021530) (98 aa) fasta scores: E(): 4.9e-14, 49.49% id in 99 aa; hypothetical protein complement(1420344..1420637) Corynebacterium diphtheriae NCTC 13129 2649477 NP_939755.1 CDS DIP1403 NC_002935.2 1420829 1421662 R Similar to Mycobacterium tuberculosis inositol-1-monophosphatase SuhB or Rv2701c or MT2775 or MTCY05A6.22c SW:SUHB_MYCTU (O07203) (290 aa) fasta scores: E(): 1e-38, 45% id in 280 aa, and to Escherichia coli inositol-1-monophosphatase SuhB or SsyA or B2533 SW:SUHB_ECOLI (P22783) (267 aa) fasta scores: E(): 3.2e-19, 37.22% id in 231 aa; hydrolase complement(1420829..1421662) Corynebacterium diphtheriae NCTC 13129 2649478 NP_939756.1 CDS ppgK NC_002935.2 1421865 1422626 D Similar to Mycobacterium tuberculosis polyphosphate glucokinase PpgK or Rv2702 or MT2776 or MTCY05A6.23 SW:PPGK_MYCTU (Q59568) (265 aa) fasta scores: E(): 1.5e-50, 57.91% id in 240 aa, and to Corynebacterium ammoniagenes polyphosphate glucokinase PpgK TR:Q9AGV8 (EMBL:AF326348) (277 aa) fasta scores: E(): 3.2e-59, 63.85% id in 249 aa; polyphosphate glucokinase 1421865..1422626 Corynebacterium diphtheriae NCTC 13129 2649479 NP_939757.1 CDS DIP1405 NC_002935.2 1422759 1422956 D hypothetical protein 1422759..1422956 Corynebacterium diphtheriae NCTC 13129 2649480 NP_939758.1 CDS sigA NC_002935.2 1423091 1424599 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; RNA polymerase sigma factor 1423091..1424599 Corynebacterium diphtheriae NCTC 13129 2649481 NP_939759.1 CDS DIP1407 NC_002935.2 1424933 1425406 R hypothetical protein complement(1424933..1425406) Corynebacterium diphtheriae NCTC 13129 2649482 NP_939760.1 CDS DIP1408 NC_002935.2 1425515 1427224 R Similar, but shorter in its N-terminal region, to Mycobacterium tuberculosis hypothetical 65.8 kDa protein Rv2917 or MT2985 or MTCY338.05 SW:YT17_MYCTU (Q10966) (602 aa) fasta scores: E(): 6.4e-116, 62.39% id in 569 aa, and to Mycobacterium leprae hypothetical 65.2 kDa protein ML1624 or MLCB250.18c SW:YT17_MYCLE (O33011) (596 aa) fasta scores: E(): 8.8e-113, 60.28% id in 569 aa; hypothetical protein complement(1425515..1427224) Corynebacterium diphtheriae NCTC 13129 2649483 NP_939761.1 CDS DIP1409 NC_002935.2 1427224 1427463 R Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT2781 TR:AAK47097 (EMBL:AE007107) (82 aa) fasta scores: E(): 1.4e-17, 65.78% id in 76 aa, and to Mycobacterium leprae U1764c ML1016 TR:Q49984 (EMBL:U15181) (107 aa) fasta scores: E(): 2.8e-16, 65.78% id in 76 aa; hypothetical protein complement(1427224..1427463) Corynebacterium diphtheriae NCTC 13129 2649484 NP_939762.1 CDS DIP1410 NC_002935.2 1427523 1428011 D hypothetical protein 1427523..1428011 Corynebacterium diphtheriae NCTC 13129 2649485 NP_939763.1 CDS DIP1411 NC_002935.2 1428054 1429589 D Similar to Streptomyces coelicolor transferase SCH5.08c TR:Q9X911 (EMBL:AL035636) (505 aa) fasta scores: E(): 3.6e-46, 35.44% id in 522 aa; transferase 1428054..1429589 Corynebacterium diphtheriae NCTC 13129 2649486 NP_939764.1 CDS DIP1412 NC_002935.2 1429600 1430037 D hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 1429600..1430037 Corynebacterium diphtheriae NCTC 13129 2649487 NP_939765.1 CDS sigB NC_002935.2 1430121 1431110 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma factors in this cluster are active during stationary phase; RNA polymerase sigma factor SigB 1430121..1431110 Corynebacterium diphtheriae NCTC 13129 2649488 NP_939766.1 CDS dtxR NC_002935.2 1431335 1432015 D Almost identical to the previously sequenced Corynebacterium diphtheriae diphtheria toxin repressor DtxR SW:DTXR_CORDI (P33120) (226 aa) fasta scores: E(): 7.6e-81, 99.11% id in 226 aa, and similar to Corynebacterium equii iron dependent regulatory protein IdeR TR:Q9F7T3 (EMBL:AF277002) (230 aa) fasta scores: E(): 1.1e-43, 56.71% id in 231 aa; diphtheria toxin repressor 1431335..1432015 Corynebacterium diphtheriae NCTC 13129 2649688 NP_939767.1 CDS galE NC_002935.2 1432038 1433024 D Almost identical to previously sequenced Corynebacterium diphtheriae UDP-glucose 4-epimerase GalE SW:GALE_CORDI (P33119) (328 aa) fasta scores: E(): 1.6e-126, 99.39% id in 328 aa, and to Corynebacterium glutamicum UDP-glucose 4-epimerase GalE SW:GALE_CORGL (Q45291) (329 aa) fasta scores: E(): 5.1e-97, 75.22% id in 327 aa, and to Lactobacillus casei UDP-glucose 4-epimerase GalE SW:GALE_LACCA (O84903) (331 aa) fasta scores: E(): 3.1e-55, 48.89% id in 317 aa; UDP-glucose 4-epimerase 1432038..1433024 Corynebacterium diphtheriae NCTC 13129 2649689 NP_939768.1 CDS DIP1416 NC_002935.2 1433073 1434116 R hypothetical protein complement(1433073..1434116) Corynebacterium diphtheriae NCTC 13129 2649690 NP_939769.1 CDS DIP1417 NC_002935.2 1434368 1435309 D Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT2787 TR:AAK47103 (EMBL:AE007107) (324 aa) fasta scores: E(): 2.1e-45, 45.09% id in 306 aa, and to Streptomyces coelicolor conserved hypothetical protein SCI52.04 TR:Q9ADA5 (EMBL:AL590507) (333 aa) fasta scores: E(): 4.2e-12, 26.64% id in 304 aa; hypothetical protein 1434368..1435309 Corynebacterium diphtheriae NCTC 13129 2649691 NP_939770.1 CDS DIP1418 NC_002935.2 1435342 1437876 D Similar in its full length to Streptomyces coelicolor helicase SCG8A.06 TR:Q9KZJ3 (EMBL:AL353863) (854 aa) fasta scores: E(): 2.1e-184, 56.4% id in 828 aa, and to the C-terminal region of Schizosaccharomyces pombe helicase SPAC6F12.16c SW:YDVG_SCHPO (O14232) (1117 aa) fasta scores: E(): 1.5e-13, 27.64% id in 445 aa; helicase 1435342..1437876 Corynebacterium diphtheriae NCTC 13129 2649692 NP_939771.1 CDS DIP1419 NC_002935.2 1437952 1438476 R Similar to Mycobacterium tuberculosis AhpD protein or Rv2429 or MT2504 or MTCY428.17c SW:AHPD_MYCTU (Q57353) (177 aa) fasta scores: E(): 1.5e-38, 59.53% id in 173 aa, and to Streptomyces viridosporus hypothetical 18.8 kDa protein AhpX TR:Q9X5V1 (EMBL:AF127576) (174 aa) fasta scores: E(): 1.5e-28, 49.13% id in 173 aa; hypothetical protein complement(1437952..1438476) Corynebacterium diphtheriae NCTC 13129 2649693 NP_939772.1 CDS dirA NC_002935.2 1438479 1439075 R Almost identical to previously sequenced Corynebacterium diphtheriae iron repressible polypeptide DirA TR:Q46025 (EMBL:U18620) (198 aa) fasta scores: E(): 8.8e-79, 98.99% id in 198 aa, and to Mycobacterium smegmatis alkyl hydroperoxide reductase C AhpC TR:Q57529 (EMBL:U43719) (195 aa) fasta scores: E(): 5.2e-52, 66.12% id in 186 aa; iron repressible polypeptide complement(1438479..1439075) Corynebacterium diphtheriae NCTC 13129 2649694 NP_939773.1 CDS DIP1421 NC_002935.2 1439301 1440239 D Similar to Erwinia carotovora hydrogen peroxide-inducible genes activator OxyR SW:OXYR_ERWCA (P71318) (302 aa) fasta scores: E(): 1.6e-34, 37.5% id in 296 aa, and to Escherichia coli hydrogen peroxide-inducible genes activator OxyR or MomR or Mor or B3961 or Z5519 or ECS4890 SW:OXYR_ECOLI (P11721) (305 aa) fasta scores: E(): 7e-34, 37.8% id in 291 aa; transcriptional regulator 1439301..1440239 Corynebacterium diphtheriae NCTC 13129 2649695 NP_939774.1 CDS DIP1422 NC_002935.2 1440295 1441260 R hypothetical protein complement(1440295..1441260) Corynebacterium diphtheriae NCTC 13129 2649696 NP_939775.1 CDS DIP1423 NC_002935.2 1441388 1445341 D Similar to Escherichia coli ATP-dependent helicase HrpA or B1413 SW:HRPA_ECOLI (P43329) (1300 aa) fasta scores: E(): 1.7e-172, 46.92% id in 1315 aa, and to Vibrio cholerae ATP-dependent helicase HrpA VC1382 TR:Q9KS77 (EMBL:AE004217) (1309 aa) fasta scores: E(): 2.3e-171, 47.6% id in 1317 aa; ATP-dependent helicase 1441388..1445341 Corynebacterium diphtheriae NCTC 13129 2649697 NP_939776.1 CDS nrdR NC_002935.2 1445404 1445859 R Similar to Mycobacterium tuberculosis hypothetical 17.2 kDa protein Rv2718c or MT2791 or MTCY05A6.39c SW:YR18_MYCTU (O07217) (154 aa) fasta scores: E(): 1.3e-35, 69.65% id in 145 aa, and to Bacillus subtilis hypothetical protein YtcG SW:YTCG_BACSU (Q45549) (152 aa) fasta scores: E(): 1.4e-21, 42% id in 150 aa; transcriptional regulator NrdR complement(1445404..1445859) Corynebacterium diphtheriae NCTC 13129 2649698 NP_939777.1 CDS DIP1425 NC_002935.2 1445957 1446292 R hypothetical protein complement(1445957..1446292) Corynebacterium diphtheriae NCTC 13129 2649699 NP_939778.1 CDS lexA NC_002935.2 1446632 1447345 D Represses a number of genes involved in the response to DNA damage; LexA repressor 1446632..1447345 Corynebacterium diphtheriae NCTC 13129 2649700 NP_939779.1 CDS DIP1427 NC_002935.2 1447668 1448444 D Similar to Streptomyces coelicolor DeoR-family transcriptional regulator SCE22.15c TR:Q9KYU7 (EMBL:AL355832) (253 aa) fasta scores: E(): 9.3e-31, 44.85% id in 243 aa, and to Escherichia coli galactitol utilization operon repressor GatR or B2087/B2090 SW:GATR_ECOLI (P36930) (259 aa) fasta scores: E(): 3.9e-20, 35.76% id in 260 aa. Note: Similar also to the downstream CDIP1429 267 aa, 41.634% identity in 257 aa overlap; sugar related operon transcriptional regulator 1447668..1448444 Corynebacterium diphtheriae NCTC 13129 2649701 NP_939780.1 CDS ptsI NC_002935.2 1448538 1450232 R Similar to Corynebacterium glutamicum phosphoenolpyruvate:sugar phosphotransferase system enzyme I PtsI TR:AAK76445 (EMBL:AF392620) (565 aa) fasta scores: E(): 2.9e-159, 76.69% id in 562 aa, and to Xanthomonas campestris multiphosphoryl transfer protein FruB SW:PTF1_XANCP (P45597) (837 aa) fasta scores: E(): 1.4e-50, 37.2% id in 559 aa; phosphoenolpyruvate:sugar phosphotransferase system enzyme I complement(1448538..1450232) Corynebacterium diphtheriae NCTC 13129 2649702 NP_939781.1 CDS DIP1429 NC_002935.2 1450500 1451303 D Similar to Spiroplasma citri transcriptional regulator FruR TR:Q9RMF6 (EMBL:AF202665) (233 aa) fasta scores: E(): 7.3e-17, 33.75% id in 237 aa, and to Escherichia coli galactitol utilization operon repressor GatR or B2087/B2090 SW:GATR_ECOLI (P36930) (259 aa) fasta scores: E(): 4e-13, 30% id in 240 aa. Note: Similar also to the upstream CDIP1427 258 aa, 41.634% identity in 257 aa overlap; sugar related operon transcriptional regulator 1450500..1451303 Corynebacterium diphtheriae NCTC 13129 2649703 NP_939782.1 CDS DIP1430 NC_002935.2 1451300 1452265 D Similar to Rhodobacter capsulatus 1-phosphofructokinase FruK SW:K1PF_RHOCA (P23386) (316 aa) fasta scores: E(): 1.2e-05, 32.6% id in 322 aa, and to Escherichia coli 6-phosphofructokinase isozyme 2 PfkB or B1723 SW:K6P2_ECOLI (P06999) (309 aa) fasta scores: E(): 0.00069, 30.51% id in 308 aa; phosphofructokinase 1451300..1452265 Corynebacterium diphtheriae NCTC 13129 2649704 NP_939783.1 CDS DIP1435 NC_002935.2 1454634 1454900 D Similar to Bacillus megaterium phosphocarrier protein HPr PtsH SW:PTHP_BACME (O69250) (88 aa) fasta scores: E(): 3e-06, 37.5% id in 80 aa, and to Bacillus subtilis phosphocarrier protein HPr PtsH SW:PTHP_BACSU (P08877) (87 aa) fasta scores: E(): 0.00032, 30.86% id in 81 aa; PTS system carbohydrate carrier protein 1454634..1454900 Corynebacterium diphtheriae NCTC 13129 2649706 NP_939784.1 CDS DIP1436 NC_002935.2 1455065 1456183 D Similar to Streptomyces coelicolor oxidoreductase SCE15.13c TR:Q9X888 (EMBL:AL049707) (367 aa) fasta scores: E(): 1.8e-106, 72.11% id in 355 aa, and to Photorhabdus luminescens alkanal monooxygenase alpha chain LuxA SW:LXA1_PHOLU (P19839) (360 aa) fasta scores: E(): 2.5e-06, 25.87% id in 228 aa; oxidoreductase 1455065..1456183 Corynebacterium diphtheriae NCTC 13129 2649707 NP_939785.1 CDS DIP1437 NC_002935.2 1456242 1456907 D Similar to Streptomyces coelicolor oxidoreductase SCE15.12c TR:Q9X887 (EMBL:AL049707) (222 aa) fasta scores: E(): 1.1e-26, 46.15% id in 221 aa, and to the middle region of Escherichia coli NAD SsuE or B0937 SW:SSUE_ECOLI (P80644) (191 aa) fasta scores: E(): 8.8e-09, 40.35% id in 114 aa; oxidoreductase 1456242..1456907 Corynebacterium diphtheriae NCTC 13129 2649708 NP_939786.1 CDS DIP1438 NC_002935.2 1456969 1458255 R Similar to Escherichia coli O157:H7 uracil transport protein PyrP TR:Q9KX94 (EMBL:AP000422) (442 aa) fasta scores: E(): 5e-46, 45.97% id in 422 aa, and to Escherichia coli uracil permease UraA or B2497 or Z3760 or ECS3359 SW:URAA_ECOLI (P33780) (429 aa) fasta scores: E(): 6.2e-25, 40.9% id in 396 aa; transport membrane protein complement(1456969..1458255) Corynebacterium diphtheriae NCTC 13129 2649709 NP_939787.1 CDS DIP1439 NC_002935.2 1458338 1459948 R Similar to Mycobacterium tuberculosis hypothetical 53.3 kDa protein HflX or Rv2725c or MTCY154.05c TR:O33230 (EMBL:Z98209) (495 aa) fasta scores: E(): 4.6e-102, 63.75% id in 469 aa, and to Escherichia coli GTP-binding protein HflX or B4173 SW:HFLX_ECOLI (P25519) (426 aa) fasta scores: E(): 3.1e-45, 40.62% id in 416 aa; GTP-binding protein complement(1458338..1459948) Corynebacterium diphtheriae NCTC 13129 2649710 NP_939788.1 CDS DIP1440 NC_002935.2 1460095 1460850 D hypothetical protein 1460095..1460850 Corynebacterium diphtheriae NCTC 13129 2649711 NP_939789.1 CDS DIP1441 NC_002935.2 1460925 1461449 D hypothetical protein 1460925..1461449 Corynebacterium diphtheriae NCTC 13129 2649712 NP_939790.1 CDS dapF NC_002935.2 1461458 1462351 R involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase complement(1461458..1462351) Corynebacterium diphtheriae NCTC 13129 2649713 NP_939791.1 CDS miaA NC_002935.2 1462348 1463256 R IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase complement(1462348..1463256) Corynebacterium diphtheriae NCTC 13129 2649714 NP_939792.1 CDS DIP1444 NC_002935.2 1463319 1464014 R hypothetical protein complement(1463319..1464014) Corynebacterium diphtheriae NCTC 13129 2649715 NP_939793.1 CDS DIP1445 NC_002935.2 1464212 1465540 D Similar to Mycobacterium tuberculosis CDC1551 hypothetical 49.8 kDa protein MT2802 TR:AAK47120 (EMBL:AE007108) (450 aa) fasta scores: E(): 5.4e-66, 48.52% id in 441 aa; hypothetical protein 1464212..1465540 Corynebacterium diphtheriae NCTC 13129 2649716 NP_939794.1 CDS DIP1446 NC_002935.2 1465728 1466753 D hypothetical protein 1465728..1466753 Corynebacterium diphtheriae NCTC 13129 2649717 NP_939795.1 CDS DIP1447 NC_002935.2 1466762 1467400 R Low similarity to Mycobacterium tuberculosis CDC1551 hypothetical 19.3 kDa protein MT2802.1 TR:AAK47121 (EMBL:AE007108) (180 aa) fasta scores: E(): 3.3e-07, 25.68% id in 183 aa; hypothetical protein complement(1466762..1467400) Corynebacterium diphtheriae NCTC 13129 2649718 NP_939796.1 CDS DIP1448 NC_002935.2 1467450 1469000 R Similar to Mycobacterium tuberculosis hypothetical 55.1 kDa protein Rv2733c or MT2803 or MTCY154.13c SW:YR33_MYCTU (O33238) (512 aa) fasta scores: E(): 2.7e-130, 67.67% id in 498 aa, and to Bacillus subtilis hypothetical 58.2 kDa protein in klb-cotE intergenic region YmcB SW:YMCB_BACSU (O31778) (509 aa) fasta scores: E(): 4.9e-65, 39.61% id in 462 aa; hypothetical protein complement(1467450..1469000) Corynebacterium diphtheriae NCTC 13129 2649719 NP_939797.1 CDS recX NC_002935.2 1469157 1469738 R binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX complement(1469157..1469738) Corynebacterium diphtheriae NCTC 13129 2649720 NP_939798.1 CDS recA NC_002935.2 1469776 1470894 R catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A complement(1469776..1470894) Corynebacterium diphtheriae NCTC 13129 2649721 NP_939799.1 CDS DIP1451 NC_002935.2 1471150 1471341 R Similar to Mycobacterium leprae hypothetical protein ML0986 TR:Q9CCC1 (EMBL:AL583920) (67 aa) fasta scores: E(): 7e-06, 39.68% id in 63 aa, and to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT2808 TR:AAK47129 (EMBL:AE007109) (68 aa) fasta scores: E(): 4.1e-05, 34.92% id in 63 aa; hypothetical protein complement(1471150..1471341) Corynebacterium diphtheriae NCTC 13129 2650336 NP_939800.1 CDS DIP1452 NC_002935.2 1471428 1472012 D Similar to Streptococcus pyogenes biotin synthase SPY0207 TR:Q9A1L4 (EMBL:AE006489) (179 aa) fasta scores: E(): 2e-15, 37.57% id in 173 aa, and to Rhizobium meliloti hypothetical transmembrane protein SMC00964 TR:CAC45460 (EMBL:AL591785) (187 aa) fasta scores: E(): 2.7e-14, 37.43% id in 179 aa; hypothetical protein 1471428..1472012 Corynebacterium diphtheriae NCTC 13129 2650337 NP_939801.1 CDS DIP1453 NC_002935.2 1472076 1472768 D Similar to Deinococcus radiodurans ABC transporter, ATP-binding protein DR2469 TR:Q9RRL9 (EMBL:AE002076) (226 aa) fasta scores: E(): 2.1e-33, 46.84% id in 222 aa, and to Rhizobium meliloti ATP-binding ABC transporter protein SMC00962 TR:CAC45462 (EMBL:AL591785) (226 aa) fasta scores: E(): 5e-27, 40.36% id in 218 aa; ABC transporter ATP-binding protein 1472076..1472768 Corynebacterium diphtheriae NCTC 13129 2650338 NP_939802.1 CDS DIP1454 NC_002935.2 1472765 1473379 D Similar to Deinococcus radiodurans conserved hypothetical protein DR2468 TR:Q9RRM0 (EMBL:AE002076) (198 aa) fasta scores: E(): 7.8e-15, 36.18% id in 199 aa, and to Rhizobium meliloti hypothetical transmembrane protein SMC00963 TR:CAC45461 (EMBL:AL591785) (201 aa) fasta scores: E(): 2.5e-07, 29.38% id in 194 aa; hypothetical protein 1472765..1473379 Corynebacterium diphtheriae NCTC 13129 2650339 NP_939803.1 CDS DIP1455 NC_002935.2 1473435 1474274 R Similar in its full length to Mycobacterium tuberculosis 35 kDa protein Rv2744c or MT2815 or MTV002.09c SW:35KD_MYCTU (P31511) (270 aa) fasta scores: E(): 1.2e-51, 75.8% id in 248 aa, N-terminal region to Mycobacterium leprae B2235_C2_187 MLCB33.06c TR:Q49840 (EMBL:U00019) (167 aa) fasta scores: E(): 2.9e-27, 72.1% id in 147 aa, and C-terminal region to Mycobacterium leprae B2235_C3_214 MLCB33.05c TR:Q49845 (EMBL:U00019) (114 aa) fasta scores: E(): 3.4e-12, 58.18% id in 110 aa; hypothetical protein complement(1473435..1474274) Corynebacterium diphtheriae NCTC 13129 2650340 NP_939804.1 CDS DIP1456 NC_002935.2 1474405 1474734 R Similar to Mycobacterium tuberculosis CDC1551 DNA-binding protein, MT2816 TR:AAK47136 (EMBL:AE007109) (112 aa) fasta scores: E(): 1.2e-09, 56.16% id in 73 aa, and to Streptomyces coelicolor hypothetical 13.6 kDa protein SC7C7.10 TR:O86815 (EMBL:AL031031) (126 aa) fasta scores: E(): 1.1e-08, 49.39% id in 83 aa; DNA-binding protein complement(1474405..1474734) Corynebacterium diphtheriae NCTC 13129 2650341 NP_939805.1 CDS DIP1457 NC_002935.2 1474823 1475320 R Similar to Streptomyces coelicolor hypothetical 18.5 kDa protein Sc7C7.09 TR:O86814 (EMBL:AL031031) (181 aa) fasta scores: E(): 1.7e-13, 36.87% id in 160 aa, and to the C-terminal region of Streptococcus pneumoniae competence-damage protein CinA or Exp10 or SP1941 SW:CINA_STRPN (P54184) (418 aa) fasta scores: E(): 4.3e-15, 47.86% id in 117 aa; competence-damage-like protein complement(1474823..1475320) Corynebacterium diphtheriae NCTC 13129 2650342 NP_939806.1 CDS DIP1458 NC_002935.2 1475349 1475939 R Similar to Bacillus subtilis CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase PgsA SW:PGSA_BACSU (P46322) (193 aa) fasta scores: E(): 1.6e-12, 40.55% id in 180 aa, and to Escherichia coli CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase PgsA or B1912 or Z3000 or ECS2650 SW:PGSA_ECOLI (P06978) (181 aa) fasta scores: E(): 1.7e-10, 35.91% id in 181 aa; phosphatidyltransferase complement(1475349..1475939) Corynebacterium diphtheriae NCTC 13129 2650343 NP_939807.1 CDS DIP1459 NC_002935.2 1476035 1476328 D Similar to Agrobacterium tumefaciens StrC58 AGR_C_4802p TR:AAK88371 (EMBL:AE008178) (97 aa) fasta scores: E(): 2.2e-05, 33.67% id in 98 aa, and to Rhizobium loti MSR4226 protein TR:Q98EI5 (EMBL:AP003003) (98 aa) fasta scores: E(): 6e-05, 32.63% id in 95 aa; hypothetical protein 1476035..1476328 Corynebacterium diphtheriae NCTC 13129 2650344 NP_939808.1 CDS DIP1460 NC_002935.2 1476411 1477418 R Similar to Streptomyces coelicolor integral membrane protein SCM1.25c TR:Q9RD18 (EMBL:AL133422) (316 aa) fasta scores: E(): 3.1e-54, 48.93% id in 327 aa, and to Xylella fastidiosa export protein XF0406 TR:Q9PG96 (EMBL:AE003892) (319 aa) fasta scores: E(): 1.3e-39, 39.43% id in 317 aa; hypothetical protein complement(1476411..1477418) Corynebacterium diphtheriae NCTC 13129 2650345 NP_939809.1 CDS DIP1461 NC_002935.2 1477699 1480752 R Similar to Streptomyces coelicolor FtsK homolog SC7C7.05 TR:O86810 (EMBL:AL031031) (929 aa) fasta scores: E(): 2.1e-106, 50.17% id in 837 aa, and similar to C-terminal region of Escherichia coli cell division protein FtsK or B0890 SW:FTSK_ECOLI (P46889) (1329 aa) fasta scores: E(): 6.5e-34, 39.14% id in 700 aa; cell division protein complement(1477699..1480752) Corynebacterium diphtheriae NCTC 13129 2650346 NP_939810.1 CDS DIP1462 NC_002935.2 1480828 1481493 R Similar to Streptomyces coelicolor hypothetical 23.6 kDa protein SC4G6.14 TR:Q9S2U0 (EMBL:AL096884) (211 aa) fasta scores: E(): 1.4e-09, 31.86% id in 204 aa, and to Mycobacterium tuberculosis hypothetical 24.0 kDa protein Rv1929c or MTCY09F9.35 TR:P95285 (EMBL:Z84498) (214 aa) fasta scores: E(): 4.3e-07, 32.71% id in 217 aa; hypothetical protein complement(1480828..1481493) Corynebacterium diphtheriae NCTC 13129 2650347 NP_939811.1 CDS DIP1463 NC_002935.2 1481579 1483633 R Similar to Corynebacterium glutamicum hypothetical 77.6 kDa protein SW:YOR4_CORGL (P54122) (718 aa) fasta scores: E(): 1.9e-189, 79.21% id in 717 aa, and to Campylobacter jejuni hypothetical protein CJ1710c TR:Q9PLW8 (EMBL:AL139079) (664 aa) fasta scores: E(): 6.9e-65, 34.08% id in 625 aa; hypothetical protein complement(1481579..1483633) Corynebacterium diphtheriae NCTC 13129 2650348 NP_939812.1 CDS dapA NC_002935.2 1483636 1484541 R catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase complement(1483636..1484541) Corynebacterium diphtheriae NCTC 13129 2650349 NP_939813.1 CDS thyX NC_002935.2 1484623 1485381 R flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor; FAD-dependent thymidylate synthase complement(1484623..1485381) Corynebacterium diphtheriae NCTC 13129 2650350 NP_939814.1 CDS dapB NC_002935.2 1485381 1486127 R catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase complement(1485381..1486127) Corynebacterium diphtheriae NCTC 13129 2650351 NP_939815.1 CDS gpsI NC_002935.2 1486307 1488574 R Similar to Mycobacterium tuberculosis guanosine pentaphosphate synthetase/ polyribonucleotide nucleotidyltransferase GpsI or Rv2783c or MTV002.48C TR:O33325 (EMBL:AL008967) (752 aa) fasta scores: E(): 1.6e-187, 71.52% id in 755 aa, and to Bacillus subtilis polyribonucleotide nucleotidyltransferase PnpA or ComR SW:PNP_BACSU (P50849) (704 aa) fasta scores: E(): 4.6e-74, 45.5% id in 723 aa, and to Corynebacterium glutamicum polyribonucleotide nucleotidyltransferase CGL1975 SWALL:Q8NP50 (EMBL:AP005280) (753 aa) fasta scores: E(): 0, 82.04% id in 752 aa; polynucleotide phosphorylase complement(1486307..1488574) Corynebacterium diphtheriae NCTC 13129 2650352 NP_939816.1 CDS rpsO NC_002935.2 1488766 1489035 R primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 complement(1488766..1489035) Corynebacterium diphtheriae NCTC 13129 2650353 NP_939817.1 CDS DIP1469 NC_002935.2 1489207 1490166 R Similar to Rhizobium meliloti nucleoside hydrolase SMC01105 TR:CAC41852 (EMBL:AL591783) (314 aa) fasta scores: E(): 2.3e-28, 33.96% id in 315 aa, and to Crithidia fasciculata inosine-uridine preferring nucleoside hydrolase IunH SW:IUNH_CRIFA (Q27546) (314 aa) fasta scores: E(): 4.6e-26, 33.33% id in 315 aa; nucleoside hydrolase complement(1489207..1490166) Corynebacterium diphtheriae NCTC 13129 2650354 NP_939818.1 CDS ribF NC_002935.2 1490204 1491175 R catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase complement(1490204..1491175) Corynebacterium diphtheriae NCTC 13129 2650355 NP_939819.1 CDS truB NC_002935.2 1491198 1492100 D catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 1491198..1492100 Corynebacterium diphtheriae NCTC 13129 2650356 NP_939820.1 CDS DIP1472 NC_002935.2 1492097 1492789 R Similar to Streptomyces coelicolor hypothetical 24.5 kDa protein Sc5A7.23 TR:O88029 (EMBL:AL031107) (226 aa) fasta scores: E(): 6.2e-26, 45.77% id in 201 aa, and to Streptomyces verticillus phosphopantetheinyl transferase PptA TR:Q9F0Q6 (EMBL:AF210311) (246 aa) fasta scores: E(): 1.6e-24, 44.04% id in 193 aa; transferase complement(1492097..1492789) Corynebacterium diphtheriae NCTC 13129 2650357 NP_939821.1 CDS DIP1473 NC_002935.2 1492786 1493592 R Similar to Mycobacterium tuberculosis hypothetical 37.6 kDa protein Rv2795c or MTV002.60c TR:O33337 (EMBL:AL008967) (324 aa) fasta scores: E(): 1e-22, 46.79% id in 265 aa, and to Streptomyces coelicolor hypothetical 33.5 kDa protein SC5A7.22 TR:O88028 (EMBL:AL031107) (295 aa) fasta scores: E(): 1.1e-17, 41.63% id in 257 aa; hypothetical protein complement(1492786..1493592) Corynebacterium diphtheriae NCTC 13129 2650358 NP_939822.1 CDS DIP1474 NC_002935.2 1493639 1494958 R Similar to Mycobacterium tuberculosis hypothetical 44.8 kDa protein DinF or Rv2836c or MTCY16B7.06 TR:P71616 (EMBL:Z81331) (439 aa) fasta scores: E(): 1e-72, 50.59% id in 423 aa, and to Rhizobium loti DNA-damage-inducible protein MLR5680 TR:Q98B90 (EMBL:AP003007) (471 aa) fasta scores: E(): 1.9e-19, 30.07% id in 429 aa; DNA-damage inducible protein complement(1493639..1494958) Corynebacterium diphtheriae NCTC 13129 2650359 NP_939823.1 CDS DIP1475 NC_002935.2 1494955 1495848 R Similar to, although shorter in its N-terminal region than, Mycobacterium tuberculosis hypothetical 35.4 kDa protein Rv2837c or MTCY16B7.05 TR:P71615 (EMBL:Z81331) (336 aa) fasta scores: E(): 8.5e-29, 34.84% id in 287 aa, and to Clostridium acetobutylicum exopolyphosphatase CAC1804 TR:AAK79769 (EMBL:AE007689) (321 aa) fasta scores: E(): 1.9e-19, 33.19% id in 235 aa; hypothetical protein complement(1494955..1495848) Corynebacterium diphtheriae NCTC 13129 2650360 NP_939824.1 CDS rbfA NC_002935.2 1495936 1496379 R associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A complement(1495936..1496379) Corynebacterium diphtheriae NCTC 13129 2650361 NP_939825.1 CDS infB NC_002935.2 1496519 1499380 R Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 complement(1496519..1499380) Corynebacterium diphtheriae NCTC 13129 2650362 NP_939826.1 CDS DIP1478 NC_002935.2 1499491 1499823 R Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT2906 TR:AAK47232 (EMBL:AE007115) (99 aa) fasta scores: E(): 1.3e-06, 43.67% id in 87 aa, and to Rhizobium meliloti hypothetical protein SMC02913 TR:CAC41675 (EMBL:AL591783) (230 aa) fasta scores: E(): 0.00061, 32.14% id in 112 aa; hypothetical protein complement(1499491..1499823) Corynebacterium diphtheriae NCTC 13129 2650363 NP_939827.1 CDS nusA NC_002935.2 1500079 1501077 R modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA complement(1500079..1501077) Corynebacterium diphtheriae NCTC 13129 2650364 NP_939828.1 CDS DIP1480 NC_002935.2 1501074 1501628 R in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein complement(1501074..1501628) Corynebacterium diphtheriae NCTC 13129 2650365 NP_939829.1 CDS DIP1481 NC_002935.2 1501680 1502588 D hypothetical protein 1501680..1502588 Corynebacterium diphtheriae NCTC 13129 2650366 NP_939830.1 CDS proS NC_002935.2 1502667 1504424 R catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase complement(1502667..1504424) Corynebacterium diphtheriae NCTC 13129 2650367 NP_939831.1 CDS DIP1483 NC_002935.2 1504456 1505202 D Similar to Streptomyces coelicolor hypothetical 27.2 kDa protein SCC30.05 TR:Q9L016 (EMBL:AL352972) (260 aa) fasta scores: E(): 4.2e-19, 34.61% id in 260 aa, and to Neisseria meningitidis hypothetical protein NMA1114 TR:Q9JUV9 (EMBL:AL162755) (259 aa) fasta scores: E(): 6.9e-08, 27.23% id in 235 aa; hypothetical protein 1504456..1505202 Corynebacterium diphtheriae NCTC 13129 2650368 NP_939832.1 CDS DIP1484 NC_002935.2 1505222 1506031 R Similar to Propionibacterium freudenreichii shermanii uroporphyrinogen III methyltransferase CobA TR:Q51720 (EMBL:U13043) (257 aa) fasta scores: E(): 1.6e-37, 47.05% id in 238 aa, and to Bacillus megaterium uroporphyrinogen III methylase CysGA TR:O87699 (EMBL:AJ000758) (243 aa) fasta scores: E(): 4.5e-32, 44.58% id in 240 aa; uroporphyrinogen III methyltransferase complement(1505222..1506031) Corynebacterium diphtheriae NCTC 13129 2650369 NP_939833.1 CDS DIP1485 NC_002935.2 1506045 1507391 D Similar to Bacillus halodurans BH3939 protein TR:Q9K5Z6 (EMBL:AP001520) (492 aa) fasta scores: E(): 6.3e-56, 41.8% id in 488 aa, and to Rhizobium meliloti hypothetical protein SMC00453 TR:CAC45554 (EMBL:AL591785) (490 aa) fasta scores: E(): 9.8e-55, 40.53% id in 491 aa; hypothetical protein 1506045..1507391 Corynebacterium diphtheriae NCTC 13129 2650370 NP_939834.1 CDS DIP1486 NC_002935.2 1507395 1508519 R Similar to Staphylococcus aureus (strain N315) hypothetical protein SA0410 or SAV0450 TR:BAB56612 (EMBL:AP003130) (400 aa) fasta scores: E(): 4.2e-50, 48.16% id in 326 aa, and to Pseudomonas denitrificans CobW protein SW:COBW_PSEDE (P29937) (353 aa) fasta scores: E(): 1.1e-19, 29.22% id in 349 aa; cobalamin synthesis-like protein complement(1507395..1508519) Corynebacterium diphtheriae NCTC 13129 2650371 NP_939835.1 CDS DIP1487 NC_002935.2 1508539 1509048 R Similar to Escherichia coli methylated-DNA--protein-cysteine methyltransferase Ogt or B1335 SW:OGT_ECOLI (P09168) (171 aa) fasta scores: E(): 8.7e-12, 32.7% id in 159 aa, and to Salmonella typhimurium methylated-DNA--protein-cysteine methyltransferase Ogt or STM1659 or STY1405 SW:OGT_SALTY (P37429) (171 aa) fasta scores: E(): 1e-10, 31.44% id in 159 aa; DNA repair-like protein complement(1508539..1509048) Corynebacterium diphtheriae NCTC 13129 2650372 NP_939836.2 CDS DIP1488 NC_002935.2 1509038 1510417 R responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid or hydrogenobrynic acid; cobyrinic acid a,c-diamide synthase complement(1509038..1510417) Corynebacterium diphtheriae NCTC 13129 2650373 NP_939837.1 CDS DIP1489 NC_002935.2 1510411 1511031 R catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase complement(1510411..1511031) Corynebacterium diphtheriae NCTC 13129 2650374 NP_939838.1 CDS mqo NC_002935.2 1513204 1514703 R malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase complement(1513204..1514703) Corynebacterium diphtheriae NCTC 13129 2650376 NP_939839.1 CDS DIP1493 NC_002935.2 1515080 1516093 D Similar to Mycobacterium tuberculosis CDC1551 hypothetical 38.2 kDa protein MT2921 TR:AAK47246 (EMBL:AE007116) (346 aa) fasta scores: E(): 5.6e-43, 40.95% id in 337 aa; hypothetical protein 1515080..1516093 Corynebacterium diphtheriae NCTC 13129 2650377 NP_939840.1 CDS DIP1494 NC_002935.2 1516191 1517582 D catalyzes the reduction of mycothione or glutathione to mycothione or glutathione disulfide; mycothione reductase 1516191..1517582 Corynebacterium diphtheriae NCTC 13129 2650378 NP_939841.1 CDS cobQ NC_002935.2 1517640 1519079 R catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation; cobyric acid synthase complement(1517640..1519079) Corynebacterium diphtheriae NCTC 13129 2650379 NP_939842.1 CDS mapB NC_002935.2 1519142 1520026 R catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mnin Bacillus subtilis the protein in this cluster is considered non-essential; methionine aminopeptidase complement(1519142..1520026) Corynebacterium diphtheriae NCTC 13129 2650380 NP_939843.1 CDS DIP1497 NC_002935.2 1520073 1521929 R Similar to Mycobacterium tuberculosis penecillin binding protein Rv2864c or MTV003.10c TR:O33346 (EMBL:AL008883) (603 aa) fasta scores: E(): 1.9e-81, 42.81% id in 612 aa, and to Staphylococcus aureus beta-lactam-inducible penicillin-binding protein Pbp SW:PBP_STAAU (P07944) (670 aa) fasta scores: E(): 2.3e-07, 21.04% id in 632 aa; secreted penicillin-binding protein complement(1520073..1521929) Corynebacterium diphtheriae NCTC 13129 2650381 NP_939844.1 CDS ispG NC_002935.2 1522046 1523221 R catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase complement(1522046..1523221) Corynebacterium diphtheriae NCTC 13129 2650382 NP_939845.1 CDS DIP1499 NC_002935.2 1523327 1524541 R Similar to Mycobacterium leprae probable integral membrane protein ML1582 TR:Q9CBU4 (EMBL:AL583922) (404 aa) fasta scores: E(): 1.1e-60, 42.71% id in 405 aa; hypothetical protein complement(1523327..1524541) Corynebacterium diphtheriae NCTC 13129 2650383 NP_939846.1 CDS dxr NC_002935.2 1524586 1525749 R catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase complement(1524586..1525749) Corynebacterium diphtheriae NCTC 13129 2650384 NP_939847.1 CDS DIP1501 NC_002935.2 1525987 1526505 D hypothetical protein 1525987..1526505 Corynebacterium diphtheriae NCTC 13129 2650385 NP_939848.1 CDS DIP1502 NC_002935.2 1526585 1527691 R 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N complement(1526585..1527691) Corynebacterium diphtheriae NCTC 13129 2650386 NP_939849.1 CDS DIP1503 NC_002935.2 1527861 1528244 D Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT3867 TR:AAK48231 (EMBL:AE007181) (117 aa) fasta scores: E(): 1.1e-09, 47.25% id in 91 aa; hypothetical protein 1527861..1528244 Corynebacterium diphtheriae NCTC 13129 2650387 NP_939850.1 CDS DIP1504 NC_002935.2 1528307 1529185 R Similar to Mycobacterium tuberculosis phosphatidate cytidylyltransferase CdsA or Rv2881c or MT2948 or MTCY274.12c SW:CDSA_MYCTU (Q10807) (306 aa) fasta scores: E(): 2.4e-51, 51.73% id in 288 aa, and to Escherichia coli phosphatidate cytidylyltransferase CdsA or Cds or B0175 or Z0186 or ECS0177 SW:CDSA_ECOLI (P06466) (249 aa) fasta scores: E(): 1.9e-14, 35.35% id in 198 aa; phospholipid biosynthesis complement(1528307..1529185) Corynebacterium diphtheriae NCTC 13129 2650388 NP_939851.1 CDS frr NC_002935.2 1529309 1529866 R Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor complement(1529309..1529866) Corynebacterium diphtheriae NCTC 13129 2650389 NP_939852.1 CDS pyrH NC_002935.2 1529938 1530747 R Catalyzes the phosphorylation of UMP to UDP; uridylate kinase complement(1529938..1530747) Corynebacterium diphtheriae NCTC 13129 2650390 NP_939853.1 CDS tsf NC_002935.2 1530890 1531717 R EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts complement(1530890..1531717) Corynebacterium diphtheriae NCTC 13129 2650391 NP_939854.1 CDS rpsB NC_002935.2 1531998 1532798 R one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 complement(1531998..1532798) Corynebacterium diphtheriae NCTC 13129 2650392 NP_939855.1 CDS DIP1509 NC_002935.2 1533166 1533699 D Similar to the N-terminal region of Mycobacterium tuberculosis hypothetical 25.8 kDa protein Rv2891 precursor or MT2958.2 or MTCY274.22 SW:YS91_MYCTU (Q10812) (249 aa) fasta scores: E(): 2.1e-14, 39.05% id in 169 aa; hypothetical protein 1533166..1533699 Corynebacterium diphtheriae NCTC 13129 2650393 NP_939856.1 CDS xerC NC_002935.2 1533714 1534622 R site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC complement(1533714..1534622) Corynebacterium diphtheriae NCTC 13129 2650394 NP_939857.1 CDS DIP1511 NC_002935.2 1534889 1536040 R Similar to Mycobacterium tuberculosis hypothetical 40.1 kDa protein Rv2896c or MT2964 or MTCY274.27C SW:YS96_MYCTU (Q10817) (389 aa) fasta scores: E(): 3.5e-42, 42.21% id in 379 aa; hypothetical protein complement(1534889..1536040) Corynebacterium diphtheriae NCTC 13129 2650395 NP_939858.1 CDS DIP1512 NC_002935.2 1536037 1537587 R Similar to Mycobacterium tuberculosis hypothetical 52.9 kDa protein Rv2897c or MT2965 or MTCY274.28C SW:YS97_MYCTU (Q10818) (503 aa) fasta scores: E(): 8.8e-58, 45.63% id in 515 aa, and to Haemophilus influenzae competence protein ComM or HI1117 SW:COMM_HAEIN (P45049) (509 aa) fasta scores: E(): 3.5e-49, 36.59% id in 511 aa; hypothetical protein complement(1536037..1537587) Corynebacterium diphtheriae NCTC 13129 2650396 NP_939859.1 CDS DIP1513 NC_002935.2 1537574 1538101 R Similar to Streptomyces coelicolor hypothetical protein SC2E1.19 SW:YE19_STRCO (O69890) (130 aa) fasta scores: E(): 2.6e-05, 32.54% id in 126 aa; hypothetical protein complement(1537574..1538101) Corynebacterium diphtheriae NCTC 13129 2650397 NP_939860.1 CDS DIP1514 NC_002935.2 1538173 1538478 R Similar to Mycobacterium tuberculosis hypothetical 12.2 kDa protein Rv2901c or MT2969 or MTCY274.32c SW:YT01_MYCTU (Q10822) (101 aa) fasta scores: E(): 3.7e-31, 70.29% id in 101 aa, and to Streptomyces coelicolor hypothetical 12.3 kDa protein SC2E1.18 TR:O69889 (EMBL:AL023797) (102 aa) fasta scores: E(): 2.9e-27, 67% id in 100 aa; hypothetical protein complement(1538173..1538478) Corynebacterium diphtheriae NCTC 13129 2650398 NP_939861.1 CDS rnhB NC_002935.2 1538491 1539180 R RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII complement(1538491..1539180) Corynebacterium diphtheriae NCTC 13129 2650399 NP_939862.1 CDS DIP1516 NC_002935.2 1539177 1540034 R Similar to Mycobacterium tuberculosis probable signal peptidase I LepB or Rv2903c or MT2971 or MTCY274.34C SW:LEP_MYCTU (Q10789) (294 aa) fasta scores: E(): 3.3e-40, 44.18% id in 258 aa, and to Bacillus licheniformis signal peptidase I Sip SW:LEP_BACLI (P42668) (186 aa) fasta scores: E(): 5.7e-08, 30.56% id in 229 aa; signal peptidase complement(1539177..1540034) Corynebacterium diphtheriae NCTC 13129 2650400 NP_939863.1 CDS DIP1517 NC_002935.2 1540598 1541410 R Similar to Escherichia coli transposase InsK for insertion sequence element IS150 or B3558 SW:INSK_ECOLI (P19769) (283 aa) fasta scores: E(): 2.3e-44, 45.62% id in 263 aa. Identical to DIP0434, DIP1526, DIP1809 and DIP2123; transposase complement(1540598..1541410) Corynebacterium diphtheriae NCTC 13129 2650401 NP_939864.1 CDS DIP1518 NC_002935.2 1541458 1541940 R Similar to Streptococcus pneumoniae hypothetical 20.7 kDa protein TR:Q9KK22 (EMBL:AF154034) (171 aa) fasta scores: E(): 1.3e-08, 33.75% id in 157 aa, and to Yersinia pestis insertion element IS1661 DNA-binding protein YPO4046 TR:CAC93502 (EMBL:AJ414160) (171 aa) fasta scores: E(): 0.00044, 25.45% id in 165 aa. Identical to DIP0435, DIP1525, DIP1808 and DIP2124; insertion element DNA-binding protein complement(1541458..1541940) Corynebacterium diphtheriae NCTC 13129 2650402 NP_939865.1 CDS DIP1519 NC_002935.2 1542092 1543009 R Similar to Corynebacterium diphtheriae secreted protein precursor TR:Q9XD85 (EMBL:AF109162) (339 aa) fasta scores: E(): 2.7e-34, 42.4% id in 250 aa; hypothetical protein complement(1542092..1543009) Corynebacterium diphtheriae NCTC 13129 2650403 NP_939866.1 CDS DIP1520 NC_002935.2 1543197 1545506 R hypothetical protein complement(1543197..1545506) Corynebacterium diphtheriae NCTC 13129 2650404 NP_939867.1 CDS DIP1521 NC_002935.2 1545659 1545772 R Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein complement(1545659..1545772) Corynebacterium diphtheriae NCTC 13129 2650405 NP_939868.1 CDS DIP1522 NC_002935.2 1545949 1546185 R Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein complement(1545949..1546185) Corynebacterium diphtheriae NCTC 13129 2650406 NP_939869.1 CDS DIP1525 NC_002935.2 1547110 1547592 D Similar to Streptococcus pneumoniae hypothetical 20.7 kDa protein TR:Q9KK22 (EMBL:AF154034) (171 aa) fasta scores: E(): 1.3e-08, 33.75% id in 157 aa, and to Yersinia pestis insertion element ISs1661 DNA-binding protein YPO4091 TR:CAC93541 (EMBL:AJ414160) (171 aa) fasta scores: E(): 0.00044, 25.45% id in 165 aa. Identical to DIP0435, DIP1518, DIP1808 and DIP2124; insertion element DNA-binding protein 1547110..1547592 Corynebacterium diphtheriae NCTC 13129 2649122 NP_939870.1 CDS DIP1526 NC_002935.2 1547640 1548452 D Similar to Escherichia coli transposase InsK for insertion sequence element IS150 or B3558 SW:INSK_ECOLI (P19769) (283 aa) fasta scores: E(): 2.3e-44, 45.62% id in 263 aa. Identical to DIP0434, DIP1517, DIP1809 and DIP2123; transposase 1547640..1548452 Corynebacterium diphtheriae NCTC 13129 2650716 NP_939871.1 CDS rplS NC_002935.2 1548534 1548875 R this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 complement(1548534..1548875) Corynebacterium diphtheriae NCTC 13129 2650717 NP_939872.1 CDS DIP1528 NC_002935.2 1549049 1551325 R Similar to Streptomyces coelicolor transcriptional accessory protein SC5F2A.26c TR:Q9X7P9 (EMBL:AL049587) (780 aa) fasta scores: E(): 8.5e-161, 59.94% id in 774 aa, and to Escherichia coli protein YhgF or B3407 SW:YHGF_ECOLI (P46837) (773 aa) fasta scores: E(): 7.3e-153, 57.44% id in 766 aa; transcriptional accessory protein complement(1549049..1551325) Corynebacterium diphtheriae NCTC 13129 2650718 NP_939873.1 CDS DIP1529 NC_002935.2 1551351 1551719 R hypothetical protein complement(1551351..1551719) Corynebacterium diphtheriae NCTC 13129 2650719 NP_939874.1 CDS trmD NC_002935.2 1551703 1552581 R methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase complement(1551703..1552581) Corynebacterium diphtheriae NCTC 13129 2650720 NP_939875.1 CDS rimM NC_002935.2 1552581 1553081 R Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM complement(1552581..1553081) Corynebacterium diphtheriae NCTC 13129 2650721 NP_939876.1 CDS rpsP NC_002935.2 1553211 1553684 R binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 complement(1553211..1553684) Corynebacterium diphtheriae NCTC 13129 2650722 NP_939877.1 CDS ffh NC_002935.2 1553918 1555534 R Similar to Mycobacterium tuberculosis signal recognition particle protein Ffh or Rv2916c or MT2984 or MTCY338.04c SW:SR54_MYCTU (Q10963) (525 aa) fasta scores: E(): 2e-110, 66.6% id in 542 aa, and to Bacillus subtilis signal recognition particle protein Ffh SW:SR54_BACSU (P37105) (446 aa) fasta scores: E(): 3.2e-43, 51.52% id in 458 aa, and to Escherichia coli signal recognition particle protein Ffh or B2610 or Z3904 or ECS3473 SW:SR54_ECOLI (P07019) (453 aa) fasta scores: E(): 2.6e-38, 46.36% id in 468 aa; signal recognition particle protein complement(1553918..1555534) Corynebacterium diphtheriae NCTC 13129 2650723 NP_939878.1 CDS glnD NC_002935.2 1555644 1557803 R Uridylylates and de-uridylylates the small trimeric protein Pii; PII uridylyl-transferase complement(1555644..1557803) Corynebacterium diphtheriae NCTC 13129 2650724 NP_939879.1 CDS glnB NC_002935.2 1557809 1558147 R Similar to Corynebacterium glutamicum PII protein GlnB TR:Q9X705 (EMBL:AJ010319) (112 aa) fasta scores: E(): 3.4e-31, 73.21% id in 112 aa, and to Azospirillum brasilense nitrogen regulatory protein P-II GlnB SW:GLNB_AZOBR (P21193) (112 aa) fasta scores: E(): 5.2e-25, 57.14% id in 112 aa, and to Escherichia coli nitrogen regulatory protein P-II 1 GlnB or B2553 or Z3829 or ECS3419 or STY2808 SW:GLNB_ECOLI (P05826) (112 aa) fasta scores: E(): 2e-24, 59.82% id in 112 aa; nitrogen regulatory protein complement(1557809..1558147) Corynebacterium diphtheriae NCTC 13129 2650725 NP_939880.1 CDS DIP1538 NC_002935.2 1559123 1560610 R Similar to Salmonella enterica subsp. enterica serovar Typhi cell division protein FtsY TR:CAD08059 (EMBL:AL627281) (491 aa) fasta scores: E(): 5e-39, 35.58% id in 503 aa, and to Escherichia coli cell division protein FtsY or B3464 SW:FTSY_ECOLI (P10121) (497 aa) fasta scores: E(): 2.6e-38, 35.79% id in 500 aa; cell division protein complement(1559123..1560610) Corynebacterium diphtheriae NCTC 13129 2650727 NP_939881.1 CDS DIP1539 NC_002935.2 1560748 1564308 R No significant database matches. High content in alanine, leucine and valine amino acid residues Low G+C content (52.14%); hypothetical protein complement(1560748..1564308) Corynebacterium diphtheriae NCTC 13129 2650728 NP_939882.1 CDS DIP1540 NC_002935.2 1564413 1567898 R Similar to Mycobacterium leprae chromosome partition protein Smc or ML1629 or MLCB250.01 SW:SMC_MYCLE (Q9CBT5) (1203 aa) fasta scores: E(): 1.4e-70, 46.09% id in 1191 aa, and to Bacillus subtilis chromosome partition protein Smc SW:SMC_BACSU (P51834) (1186 aa) fasta scores: E(): 2.1e-34, 28.92% id in 1217 aa. Note: Contains various possible colied-coil regions throughout the whole length of the CDS; chromosome partition protein complement(1564413..1567898) Corynebacterium diphtheriae NCTC 13129 2650729 NP_939883.1 CDS DIP1541 NC_002935.2 1567923 1568210 R Similar to Mycobacterium tuberculosis acylphosphatase Rv2922.1c or MT2991 or MTCY338.11bc SW:ACYP_MYCTU (P56543) (93 aa) fasta scores: E(): 1.3e-14, 52.08% id in 96 aa, and to Escherichia coli acylphosphatase YccX or B0968 or Z1320 or ECS1052 SW:ACYP_ECOLI (P75877) (92 aa) fasta scores: E(): 1.2e-07, 43.82% id in 89 aa; acylphosphatase complement(1567923..1568210) Corynebacterium diphtheriae NCTC 13129 2650730 NP_939884.1 CDS DIP1542 NC_002935.2 1568210 1569697 R Similar to Staphylococcus aureus (strain N315) amino acid carrier protein AlsT or SA1190 or SAV1356 TR:BAB57518 (EMBL:AP003133) (486 aa) fasta scores: E(): 5.8e-84, 48.83% id in 473 aa, and to Bacillus subtilis amino acid carrier protein AlsT SW:ALST_BACSU (Q45068) (465 aa) fasta scores: E(): 1.3e-73, 46.18% id in 472 aa; amino acid carrier protein complement(1568210..1569697) Corynebacterium diphtheriae NCTC 13129 2650731 NP_939885.1 CDS DIP1543 NC_002935.2 1569776 1570666 R Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase complement(1569776..1570666) Corynebacterium diphtheriae NCTC 13129 2650732 NP_939886.1 CDS rnc NC_002935.2 1570684 1571433 R cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III complement(1570684..1571433) Corynebacterium diphtheriae NCTC 13129 2650733 NP_939887.1 CDS DIP1545 NC_002935.2 1571430 1571960 R Similar to the C-terminal region of Mycobacterium tuberculosis hypothetical 22.4 kDa protein Rrv2926c or MT2996 or MTCY338.15c SW:YT26_MYCTU (Q10972) (207 aa) fasta scores: E(): 9.5e-13, 30.46% id in 174 aa; hypothetical protein complement(1571430..1571960) Corynebacterium diphtheriae NCTC 13129 2650734 NP_939888.1 CDS DIP1546 NC_002935.2 1572001 1572714 R Similar to Mycobacterium tuberculosis hypothetical 27.0 kDa protein Rv2927c or MT2997 or MTCY338.16c SW:YT27_MYCTU (Q10973) (245 aa) fasta scores: E(): 9e-21, 47.89% id in 238 aa; hypothetical protein complement(1572001..1572714) Corynebacterium diphtheriae NCTC 13129 2650735 NP_939889.1 CDS gdh NC_002935.2 1572978 1574324 R converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase complement(1572978..1574324) Corynebacterium diphtheriae NCTC 13129 2650736 NP_939890.1 CDS DIP1548 NC_002935.2 1574742 1575908 D Similar to Bacillus halodurans glycerate kinase GlxK or BH0555 SW:GRK_BACHD (Q9Z9P2) (380 aa) fasta scores: E(): 1e-29, 35.14% id in 350 aa, and to Bacillus subtilis glycerate kinase GlxK or S14A SW:GRK_BACSU (P42100) (382 aa) fasta scores: E(): 7.1e-28, 32.4% id in 395 aa, and to Escherichia coli glycerate kinase 1 GlxK or GlxB5 or B0514 SW:GRK1_ECOLI (P77364) (381 aa) fasta scores: E(): 7.6e-25, 33.93% id in 333 aa; glycerate kinase 1574742..1575908 Corynebacterium diphtheriae NCTC 13129 2650737 NP_939891.1 CDS DIP1549 NC_002935.2 1575878 1576306 R hypothetical protein complement(1575878..1576306) Corynebacterium diphtheriae NCTC 13129 2650738 NP_939892.1 CDS DIP1550 NC_002935.2 1576350 1577666 D hypothetical protein 1576350..1577666 Corynebacterium diphtheriae NCTC 13129 2650739 NP_939893.1 CDS DIP1551 NC_002935.2 1577710 1579014 D Similar to Streptomyces coelicolor peptidase SCD17.07c TR:Q9RKM4 (EMBL:AL118515) (423 aa) fasta scores: E(): 6.6e-71, 45.3% id in 415 aa, and to Thermoplasma volcanium carboxypeptidase TVG0758219 TR:BAB59893 (EMBL:AP000993) (404 aa) fasta scores: E(): 2.1e-34, 34.03% id in 379 aa; peptidase 1577710..1579014 Corynebacterium diphtheriae NCTC 13129 2650740 NP_939894.1 CDS DIP1552 NC_002935.2 1579137 1581566 D Similar to Escherichia coli maltodextrin phosphorylase MalP or B3417 SW:PHSM_ECOLI (P00490) (796 aa) fasta scores: E(): 5.5e-100, 44.48% id in 780 aa, and to Bacillus subtilis glycogen phosphorylase GlgP SW:PHSG_BACSU (P39123) (798 aa) fasta scores: E(): 1.2e-98, 45.43% id in 777 aa; glycogen phosphorylase 1579137..1581566 Corynebacterium diphtheriae NCTC 13129 2650741 NP_939895.1 CDS pyk NC_002935.2 1581632 1583053 R catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase complement(1581632..1583053) Corynebacterium diphtheriae NCTC 13129 2650742 NP_939896.1 CDS DIP1554 NC_002935.2 1583263 1584114 R transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase complement(1583263..1584114) Corynebacterium diphtheriae NCTC 13129 2650743 NP_939897.1 CDS trpC2 NC_002935.2 1584186 1584998 R Similar to Mycobacterium tuberculosis indole-3-glycerol phosphate synthase TrpC or Rv1611 or MT1646 or MTCY01B2.03 SW:TRPC_MYCTU (O06129) (272 aa) fasta scores: E(): 1.4e-52, 55.59% id in 268 aa, and to Streptomyces coelicolor indole-3-glycerol phosphate synthase 1 TrpC1 or TrpC or SC4G6.08c SW:TRC1_STRCO (O68814) (269 aa) fasta scores: E(): 1.1e-44, 48.28% id in 263 aa; indole-3-glycerol phosphate synthase complement(1584186..1584998) Corynebacterium diphtheriae NCTC 13129 2650744 NP_939898.1 CDS DIP1556 NC_002935.2 1585111 1585686 R Low similarity to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT1645 TR:AAK45914 (EMBL:AE007029) (235 aa) fasta scores: E(): 1e-08, 28.64% id in 206 aa; hypothetical protein complement(1585111..1585686) Corynebacterium diphtheriae NCTC 13129 2650745 NP_939899.1 CDS hisI NC_002935.2 1585787 1586137 R PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers; phosphoribosyl-AMP cyclohydrolase complement(1585787..1586137) Corynebacterium diphtheriae NCTC 13129 2650746 NP_939900.1 CDS hisF NC_002935.2 1586159 1586935 R catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF complement(1586159..1586935) Corynebacterium diphtheriae NCTC 13129 2650747 NP_939901.1 CDS impA NC_002935.2 1587026 1587811 R Similar to Corynebacterium glutamicum inositol monophosphate phosphatase ImpA TR:O52736 (EMBL:AF045998) (259 aa) fasta scores: E(): 3.2e-42, 50.42% id in 236 aa, and to Mycobacterium smegmatis inositol monophosphate phosphatase ImpA TR:O51845 (EMBL:AF005905) (276 aa) fasta scores: E(): 8e-34, 42.35% id in 255 aa; inositol monophosphatase complement(1587026..1587811) Corynebacterium diphtheriae NCTC 13129 2650748 NP_939902.1 CDS hisA NC_002935.2 1587808 1588536 R catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide and the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)anthranilate; involved in histidine and tryptophan biosynthesis; phosphoribosyl isomerase A complement(1587808..1588536) Corynebacterium diphtheriae NCTC 13129 2650749 NP_939903.1 CDS hisH NC_002935.2 1588634 1589266 R with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH complement(1588634..1589266) Corynebacterium diphtheriae NCTC 13129 2650750 NP_939904.1 CDS DIP1562 NC_002935.2 1589333 1590745 R Similar to Streptomyces coelicolor transmembrane transport protein SC5G9.26c TR:Q9RL01 (EMBL:AL117385) (420 aa) fasta scores: E(): 8e-11, 28.37% id in 437 aa, and to Streptomyces lipmanii puromycin resistance protein Pur8 SW:PUR8_STRLP (P42670) (503 aa) fasta scores: E(): 2.4e-08, 24.39% id in 455 aa; transport membrane protein complement(1589333..1590745) Corynebacterium diphtheriae NCTC 13129 2650751 NP_939905.1 CDS DIP1563 NC_002935.2 1590914 1591129 R hypothetical protein complement(1590914..1591129) Corynebacterium diphtheriae NCTC 13129 2650752 NP_939906.1 CDS hisB NC_002935.2 1591132 1591740 R catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis; imidazoleglycerol-phosphate dehydratase complement(1591132..1591740) Corynebacterium diphtheriae NCTC 13129 2650753 NP_939907.1 CDS hisC NC_002935.2 1591822 1592922 R catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase complement(1591822..1592922) Corynebacterium diphtheriae NCTC 13129 2650754 NP_939908.1 CDS hisD NC_002935.2 1592961 1594310 R catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase complement(1592961..1594310) Corynebacterium diphtheriae NCTC 13129 2650755 NP_939909.1 CDS DIP1567 NC_002935.2 1594635 1595690 D hypothetical protein 1594635..1595690 Corynebacterium diphtheriae NCTC 13129 2650756 NP_939910.1 CDS DIP1568 NC_002935.2 1595728 1595955 D Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 1595728..1595955 Corynebacterium diphtheriae NCTC 13129 2650757 NP_939911.1 CDS DIP1569 NC_002935.2 1595969 1596226 D Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 1595969..1596226 Corynebacterium diphtheriae NCTC 13129 2650758 NP_939912.1 CDS DIP1570 NC_002935.2 1596430 1597092 R hypothetical protein complement(1596430..1597092) Corynebacterium diphtheriae NCTC 13129 2650759 NP_939913.1 CDS DIP1571 NC_002935.2 1597317 1597862 D Similar to Escherichia coli tetracycline repressor protein class D TetR SW:TER4_ECOLI (P09164) (217 aa) fasta scores: E(): 8.1e-09, 30.48% id in 187 aa, and to Pasteurella piscicida tetracycline repressor protein class H TetR SW:TER8_PASPI (P51562) (218 aa) fasta scores: E(): 8.1e-09, 30.48% id in 187 aa; TetR family transcriptional regulator 1597317..1597862 Corynebacterium diphtheriae NCTC 13129 2650760 NP_939914.1 CDS glgX NC_002935.2 1597883 1600090 D Similar to Mycobacterium tuberculosis glycogen operon protein GlgX homolog or Rv1564c or MT1615 or MTCY48.01 SW:GLGX_MYCTU (Q10767) (721 aa) fasta scores: E(): 5.5e-205, 69.12% id in 706 aa, and to Escherichia coli glycogen operon protein GlgX or GlyX or B3431 SW:GLGX_ECOLI (P15067) (657 aa) fasta scores: E(): 8.1e-87, 46.38% id in 664 aa; hypothetical protein 1597883..1600090 Corynebacterium diphtheriae NCTC 13129 2650761 NP_939915.1 CDS DIP1573 NC_002935.2 1600226 1601572 D Similar to Clostridium acetobutylicum DNA polymerase III epsilon subunit CAC0738 TR:AAK78714 (EMBL:AE007589) (306 aa) fasta scores: E(): 1.4e-14, 28.9% id in 339 aa, and to the exonuclease domain of Bacillus halodurans DNA polymerase III PolC-type PolC or BH2418 SW:DPO3_BACHD (Q9KA72) (1433 aa) fasta scores: E(): 2.7e-08, 28.62% id in 248 aa; DNA polymerase III subunit epsilon 1600226..1601572 Corynebacterium diphtheriae NCTC 13129 2650762 NP_939916.1 CDS DIP1574 NC_002935.2 1601707 1602324 D hypothetical protein 1601707..1602324 Corynebacterium diphtheriae NCTC 13129 2650763 NP_939917.1 CDS DIP1575 NC_002935.2 1602408 1603427 D Similar to N-terminal region of Deinococcus radiodurans conserved hypothetical protein DRr1631 TR:Q9RTX1 (EMBL:AE002006) (394 aa) fasta scores: E(): 4.7e-12, 31.28% id in 211 aa; hypothetical protein 1602408..1603427 Corynebacterium diphtheriae NCTC 13129 2650764 NP_939918.1 CDS DIP1576 NC_002935.2 1603691 1604068 R Similar to Rhizobium loti MLR3853 protein TR:Q98FB3 (EMBL:AP003002) (131 aa) fasta scores: E(): 2.9e-09, 42.01% id in 119 aa, and to Escherichia coli heat shock protein 15 HslR or B3400 or Z4754 or ECS4242 SW:HSLR_ECOLI (P45802) (133 aa) fasta scores: E(): 2.7e-06, 32.54% id in 126 aa; RNA-binding heat shock protein complement(1603691..1604068) Corynebacterium diphtheriae NCTC 13129 2650765 NP_939919.1 CDS DIP1577 NC_002935.2 1604074 1604304 R hypothetical protein complement(1604074..1604304) Corynebacterium diphtheriae NCTC 13129 2650766 NP_939920.1 CDS DIP1578 NC_002935.2 1604330 1604971 R Similar to Bacillus subtilis hypothetical 24.8 kDa protein in degS-tagO intergenic region YvyE or YvhK SW:YVYE_BACSU (P32437) (217 aa) fasta scores: E(): 1.3e-24, 37.5% id in 208 aa; hypothetical protein complement(1604330..1604971) Corynebacterium diphtheriae NCTC 13129 2650767 NP_939921.1 CDS ilvA NC_002935.2 1604995 1606335 R catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic; threonine dehydratase complement(1604995..1606335) Corynebacterium diphtheriae NCTC 13129 2650768 NP_939922.1 CDS dnaE NC_002935.2 1606336 1609896 R catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha complement(1606336..1609896) Corynebacterium diphtheriae NCTC 13129 2650769 NP_939923.1 CDS DIP1581 NC_002935.2 1610019 1610918 D Similar to Streptomyces coelicolor integral membrane protein SCD20.10c TR:Q9F2W9 (EMBL:AL392148) (362 aa) fasta scores: E(): 2.4e-45, 45.54% id in 292 aa; hypothetical protein 1610019..1610918 Corynebacterium diphtheriae NCTC 13129 2650770 NP_939924.1 CDS DIP1582 NC_002935.2 1610892 1611437 R hypothetical protein complement(1610892..1611437) Corynebacterium diphtheriae NCTC 13129 2650771 NP_939925.1 CDS rluC NC_002935.2 1611445 1612371 R Similar to Mycobacterium leprae pseudouridine synthase RluC or ML1200 or MLCB458.15 TR:Q9X7E8 (EMBL:AL049478) (308 aa) fasta scores: E(): 1.2e-79, 68.62% id in 306 aa, and to Streptomyces coelicolor ribosomal large subunit pseudouridine synthase SC4A10.06c TR:Q9S2X8 (EMBL:AL109663) (314 aa) fasta scores: E(): 8.5e-75, 64.37% id in 306 aa; pseudouridine synthase complement(1611445..1612371) Corynebacterium diphtheriae NCTC 13129 2650772 NP_939926.1 CDS DIP1584 NC_002935.2 1612368 1612892 R Similar to Streptomyces coelicolor lipoprotein signal peptidase SC4A10.07c TR:Q9S2X7 (EMBL:AL109663) (204 aa) fasta scores: E(): 1e-20, 43.03% id in 165 aa, and to Bacillus subtilis lipoprotein signal peptidase LspA or Lps SW:LSPA_BACSU (Q45479) (154 aa) fasta scores: E(): 1.7e-11, 35.71% id in 154 aa; lipoprotein signal peptidase complement(1612368..1612892) Corynebacterium diphtheriae NCTC 13129 2650773 NP_939927.1 CDS DIP1585 NC_002935.2 1612953 1613918 D hypothetical protein 1612953..1613918 Corynebacterium diphtheriae NCTC 13129 2650774 NP_939928.1 CDS DIP1586 NC_002935.2 1614007 1614627 R Similar to Mycobacterium tuberculosis lipoprotein LppK precursor or Rv2116 or MT2176 or MTCY261.12 SW:LPPK_MYCTU (O33251) (189 aa) fasta scores: E(): 0.0014, 30.48% id in 187 aa; hypothetical protein complement(1614007..1614627) Corynebacterium diphtheriae NCTC 13129 2650775 NP_939929.1 CDS DIP1587 NC_002935.2 1614825 1615745 D Similar to Mycobacterium leprae probable L-asparaginase AnsA or ML1198 or MLCB458.13c SW:ASPG_MYCLE (Q9X7E6) (310 aa) fasta scores: E(): 4.7e-19, 37.65% id in 316 aa, and to Erwinia chrysanthemi L-asparaginase precursor AnsB or Asn SW:ASPG_ERWCH (P06608) (348 aa) fasta scores: E(): 3.4e-09, 29.51% id in 332 aa. Also similar to DIP0491 E(): 2e-48, 52.303% identity in 304 aa overlap; L-asparaginase 1614825..1615745 Corynebacterium diphtheriae NCTC 13129 2650776 NP_939930.1 CDS dinB NC_002935.2 1615746 1617101 R involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV complement(1615746..1617101) Corynebacterium diphtheriae NCTC 13129 2650777 NP_939931.1 CDS ileS NC_002935.2 1617227 1620385 R IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin); isoleucyl-tRNA synthetase complement(1617227..1620385) Corynebacterium diphtheriae NCTC 13129 2650778 NP_939932.1 CDS ag84 NC_002935.2 1620783 1621784 R Similar to Corynebacterium glutamicum antigen 84 Wag31 TR:Q9L4H7 (EMBL:AJ242594) (365 aa) fasta scores: E(): 1.7e-21, 60.66% id in 361 aa, and to Mycobacterium leprae antigen 84 Ag84 or ML0922 SW:AG84_MYCLE (P46815) (266 aa) fasta scores: E(): 1.8e-14, 43.97% id in 332 aa, and to Mycobacterium tuberculosis antigen 84 Ag84 or Wag31 or Rv2145c or MT2204 or MTCY270.23 SW:AG84_MYCTU (P46816) (260 aa) fasta scores: E(): 6.3e-14, 44.27% id in 332 aa. Note: Contains three colied-coil regions (residues 84..131, 193..235, 248..273); hypothetical protein complement(1620783..1621784) Corynebacterium diphtheriae NCTC 13129 2650779 NP_939933.1 CDS DIP1591 NC_002935.2 1622125 1622412 R Similar to Streptomyces coelicolor hypothetical 10.7 kDa protein SC4A10.11c TR:Q9S2X3 (EMBL:AL109663) (94 aa) fasta scores: E(): 2.6e-09, 34.78% id in 92 aa, and to Mycobacterium leprae possible membrane protein ML0921 TR:Q9CCE0 (EMBL:AL583920) (96 aa) fasta scores: E(): 6.7e-09, 41.57% id in 89 aa; hypothetical protein complement(1622125..1622412) Corynebacterium diphtheriae NCTC 13129 2650780 NP_939934.1 CDS DIP1592 NC_002935.2 1622397 1622597 R Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein complement(1622397..1622597) Corynebacterium diphtheriae NCTC 13129 2650781 NP_939935.1 CDS DIP1593 NC_002935.2 1622609 1623058 R Similar to Corynebacterium glutamicum Yak1 protein TR:Q9KX18 (EMBL:Y08964) (152 aa) fasta scores: E(): 1.1e-21, 52.9% id in 155 aa, and to Streptomyces coelicolor conserved hypothetical protein 2SCI34.02 TR:Q9EWX7 (EMBL:AL445403) (146 aa) fasta scores: E(): 9.1e-07, 31.88% id in 138 aa; hypothetical protein complement(1622609..1623058) Corynebacterium diphtheriae NCTC 13129 2650782 NP_939936.1 CDS DIP1594 NC_002935.2 1623168 1623908 R Similar to Corynebacterium glutamicum hypothetical 26.0 kDa protein in FtsZ 3'region SW:YFTZ_CORGL (P94338) (246 aa) fasta scores: E(): 6.5e-66, 68.72% id in 243 aa, and to Streptomyces griseus hypothetical 25.3 kDa protein in FtsZ 3'region SW:YFTZ_STRGR (P45496) (246 aa) fasta scores: E(): 7.4e-41, 50% id in 228 aa; hypothetical protein complement(1623168..1623908) Corynebacterium diphtheriae NCTC 13129 2650783 NP_939937.1 CDS ftsZ NC_002935.2 1623908 1625143 R GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ complement(1623908..1625143) Corynebacterium diphtheriae NCTC 13129 2650784 NP_939938.1 CDS DIP1596 NC_002935.2 1625535 1626191 R Similar to Corynebacterium glutamicum cell division protein homolog FtsQ or DivB SW:FTSQ_CORGL (P94336) (222 aa) fasta scores: E(): 3.3e-30, 41.36% id in 220 aa, and to Mycobacterium tuberculosis cell division protein homolog FtsQ or Rv2151c or MT2210 or MTCY270.17 SW:FTSQ_MYCTU (O06226) (314 aa) fasta scores: E(): 4e-16, 32.4% id in 216 aa; cell division protein complement(1625535..1626191) Corynebacterium diphtheriae NCTC 13129 2650785 NP_939939.1 CDS murC NC_002935.2 1626188 1627621 R Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase complement(1626188..1627621) Corynebacterium diphtheriae NCTC 13129 2650786 NP_939940.1 CDS murG NC_002935.2 1627639 1628718 R UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase complement(1627639..1628718) Corynebacterium diphtheriae NCTC 13129 2650787 NP_939941.1 CDS DIP1599 NC_002935.2 1628720 1630228 R Similar to Corynebacterium glutamicum FtsW protein TR:Q9L4H4 (EMBL:AJ242646) (490 aa) fasta scores: E(): 9.6e-78, 48.85% id in 481 aa, and to Escherichia coli cell division protein FtsW or B0089 or Z0099 or ECS0093 SW:FTSW_ECOLI (P16457) (414 aa) fasta scores: E(): 1e-21, 32.53% id in 375 aa; cell division protein complement(1628720..1630228) Corynebacterium diphtheriae NCTC 13129 2650788 NP_939942.1 CDS murD NC_002935.2 1630255 1631697 R UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase complement(1630255..1631697) Corynebacterium diphtheriae NCTC 13129 2650789 NP_939943.1 CDS mraY NC_002935.2 1631702 1632820 R First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase complement(1631702..1632820) Corynebacterium diphtheriae NCTC 13129 2650790 NP_939944.1 CDS murF NC_002935.2 1632828 1634318 R Similar to Mycobacterium tuberculosis UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-- D-alanyl-D- alanyl ligase MurF or Rv2157c or MT2216 or MTCY270.11 SW:MURF_MYCTU (O06220) (510 aa) fasta scores: E(): 2.3e-75, 49.7% id in 513 aa, and to Streptomyces toyocaensis probable UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-- D- alanyl-D-alanyl ligase MurF or MurX SW:MURF_STRTO (O33804) (443 aa) fasta scores: E(): 3.9e-30, 40.6% id in 495 aa; UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase complement(1632828..1634318) Corynebacterium diphtheriae NCTC 13129 2650791 NP_939945.1 CDS murE NC_002935.2 1634372 1635913 R involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase complement(1634372..1635913) Corynebacterium diphtheriae NCTC 13129 2650792 NP_939946.1 CDS ftsI NC_002935.2 1636021 1638045 R Similar to Corynebacterium glutamicum penicillin-binding protein FtsI TR:Q9FAD4 (EMBL:AB041009) (704 aa) fasta scores: E(): 3.1e-122, 59.38% id in 677 aa, and to Streptomyces coelicolor FtsI TR:Q9Z5V7 (EMBL:AF123319) (651 aa) fasta scores: E(): 2e-42, 32.24% id in 611 aa; penicillin-binding (cell division related) protein complement(1636021..1638045) Corynebacterium diphtheriae NCTC 13129 2650793 NP_939947.1 CDS DIP1605 NC_002935.2 1638076 1638849 R hypothetical protein complement(1638076..1638849) Corynebacterium diphtheriae NCTC 13129 2650794 NP_939948.1 CDS mraW NC_002935.2 1638906 1639925 R Similar to Mycobacterium tuberculosis hypothetical 37.2 kDa protein Rv2165c or MT2223 or MTCY270.03 SW:YL65_MYCTU (O06212) (344 aa) fasta scores: E(): 4.8e-62, 56.34% id in 323 aa; S-adenosyl-methyltransferase MraW complement(1638906..1639925) Corynebacterium diphtheriae NCTC 13129 2650795 NP_939949.1 CDS DIP1607 NC_002935.2 1640108 1640539 R MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ complement(1640108..1640539) Corynebacterium diphtheriae NCTC 13129 2650796 NP_939950.1 CDS DIP1608 NC_002935.2 1641087 1641491 R Similar to Mycobacterium tuberculosis hypothetical 14.6 kDa protein Rv2169c or MTV021.02c TR:O53503 (EMBL:AL021957) (134 aa) fasta scores: E(): 8.5e-11, 38.93% id in 131 aa; hypothetical protein complement(1641087..1641491) Corynebacterium diphtheriae NCTC 13129 2650797 NP_939951.1 CDS DIP1609 NC_002935.2 1641600 1642154 R hypothetical protein complement(1641600..1642154) Corynebacterium diphtheriae NCTC 13129 2650798 NP_939952.1 CDS DIP1610 NC_002935.2 1642218 1642796 D Similar to Mycobacterium tuberculosis hypothetical 22.9 kDa protein Rv2170 or MTV021.03 TR:O53504 (EMBL:AL021957) (206 aa) fasta scores: E(): 3.4e-16, 35.14% id in 202 aa; hypothetical protein 1642218..1642796 Corynebacterium diphtheriae NCTC 13129 2650799 NP_939953.1 CDS DIP1611 NC_002935.2 1642793 1643776 R Similar to Streptomyces lividans 5,10-methylenetetrahydrofolate reductase MetF SW:METF_STRLI (O54235) (307 aa) fasta scores: E(): 4.1e-41, 41.58% id in 303 aa, and to Escherichia coli 5,10-methylenetetrahydrofolate reductase MetF or B3941 SW:METF_ECOLI (P00394) (296 aa) fasta scores: E(): 9.2e-15, 33.65% id in 309 aa; methylenetetrahydrofolate reductase complement(1642793..1643776) Corynebacterium diphtheriae NCTC 13129 2650800 NP_939954.1 CDS DIP1612 NC_002935.2 1643980 1645104 D Similar to Mycobacterium aurum geranylgeranyl pyrophosphate synthase GgpP TR:Q9K567 (EMBL:AJ133724) (371 aa) fasta scores: E(): 1.5e-36, 39.09% id in 353 aa, and to Sulfolobus acidocaldarius geranylgeranyl pyrophosphate synthetase Gds SW:GGPP_SULAC (P39464) (330 aa) fasta scores: E(): 3.1e-11, 28.49% id in 358 aa; geranylgeranyl pyrophosphate synthase 1643980..1645104 Corynebacterium diphtheriae NCTC 13129 2650801 NP_939955.1 CDS DIP1613 NC_002935.2 1645126 1646613 D Similar to Mycobacterium tuberculosis membrane protein Rv2174 or MTV021.07 TR:O53508 (EMBL:AL021957) (516 aa) fasta scores: E(): 2.2e-56, 34.69% id in 464 aa; hypothetical protein 1645126..1646613 Corynebacterium diphtheriae NCTC 13129 2650802 NP_939956.1 CDS DIP1614 NC_002935.2 1646614 1646982 R Similar to Mycobacterium tuberculosis hypothetical 15.7 kDa protein Rv2175c or MTV021.08c TR:O53509 (EMBL:AL021957) (146 aa) fasta scores: E(): 7.8e-08, 40.45% id in 131 aa; hypothetical protein complement(1646614..1646982) Corynebacterium diphtheriae NCTC 13129 2650803 NP_939957.1 CDS DIP1615 NC_002935.2 1647084 1649276 D Similar to Streptomyces coelicolor eukaryotic-type protein kinase PkaF TR:Q9ZNB3 (EMBL:AB019394) (629 aa) fasta scores: E(): 8.2e-37, 36.22% id in 646 aa; serine/threonine protein kinase 1647084..1649276 Corynebacterium diphtheriae NCTC 13129 2650804 NP_939958.1 CDS aroH NC_002935.2 1649344 1650732 R Similar to Streptomyces coelicolor phospho-2-dehydro-3-deoxyheptonate aldolase AroH or SC6E10.09c SW:AROF_STRCO (P80574) (449 aa) fasta scores: E(): 2.4e-92, 55.6% id in 437 aa, and to Mycobacterium tuberculosis CDC1551 phospho-2-dehydro-3-deoxyheptonate aldolase, MT2234 TR:AAK46519 (EMBL:AE007070) (462 aa) fasta scores: E(): 2.9e-129, 67.53% id in 462 aa; phospho-2-dehydro-3-deoxyheptonate aldolase complement(1649344..1650732) Corynebacterium diphtheriae NCTC 13129 2650805 NP_939959.1 CDS DIP1617 NC_002935.2 1650846 1651355 R Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT2234.1 TR:AAK46520 (EMBL:AE007070) (168 aa) fasta scores: E(): 1.1e-35, 59.35% id in 155 aa; hypothetical protein complement(1650846..1651355) Corynebacterium diphtheriae NCTC 13129 2648663 NP_939960.1 CDS DIP1618 NC_002935.2 1651422 1652147 R Similar to Corynebacterium glutamicum hypothetical 27.1 kDa protein TR:Q9KKE6 (EMBL:AF096280) (245 aa) fasta scores: E(): 1.9e-67, 67.91% id in 240 aa, and to Streptomyces coelicolor acyltransferase 2SCG1.03 TR:Q9FCD9 (EMBL:AL391014) (240 aa) fasta scores: E(): 1.3e-37, 46.63% id in 238 aa; acyltransferase complement(1651422..1652147) Corynebacterium diphtheriae NCTC 13129 2648664 NP_939961.1 CDS glk NC_002935.2 1652199 1653152 R Similar to Corynebacterium glutamicum glucose kinase Glk TR:Q9KKE7 (EMBL:AF096280) (323 aa) fasta scores: E(): 2.5e-79, 62.38% id in 319 aa, and to Streptomyces coelicolor glucokinase Glk or SC6E10.20c SW:GLK_STRCO (P40184) (317 aa) fasta scores: E(): 5.7e-45, 40% id in 310 aa; glucose kinase complement(1652199..1653152) Corynebacterium diphtheriae NCTC 13129 2648665 NP_939962.1 CDS DIP1620 NC_002935.2 1653283 1654416 R Similar to Mycobacterium leprae hypothetical 41.1 kDa protein ML0886 or MLCB268.31c TR:O69579 (EMBL:AL022602) (384 aa) fasta scores: E(): 1.9e-64, 51.18% id in 381 aa, and to Mycobacterium tuberculosis CDC1551 glycosyl transferase MT2243 TR:AAK46529 (EMBL:AE007070) (385 aa) fasta scores: E(): 8e-64, 50.65% id in 381 aa; hypothetical protein complement(1653283..1654416) Corynebacterium diphtheriae NCTC 13129 2648666 NP_939963.1 CDS DIP1621 NC_002935.2 1654437 1655450 R Similar to Mycobacterium leprae secreted protein ML0885 or MLCB268.32c TR:O69580 (EMBL:AL022602) (374 aa) fasta scores: E(): 1.7e-22, 36.2% id in 348 aa; hypothetical protein complement(1654437..1655450) Corynebacterium diphtheriae NCTC 13129 2648667 NP_939964.1 CDS DIP1622 NC_002935.2 1655620 1656384 R Similar to the C-terminal region of Mycobacterium leprae secreted protein ML0885 or MLCB268.32c TR:O69580 (EMBL:AL022602) (374 aa) fasta scores: E(): 6e-19, 40.35% id in 223 aa; hypothetical protein complement(1655620..1656384) Corynebacterium diphtheriae NCTC 13129 2648668 NP_939965.1 CDS DIP1623 NC_002935.2 1656493 1656735 R hypothetical protein complement(1656493..1656735) Corynebacterium diphtheriae NCTC 13129 2648669 NP_939966.1 CDS qcrB NC_002935.2 1657014 1658636 R Similar to Corynebacterium glutamicum cytochrome B of BC1 complex CytB or QcrB TR:Q9AEL5 (EMBL:AJ306418) (539 aa) fasta scores: E(): 1.1e-173, 81.08% id in 534 aa, and to Streptomyces lividans ubiquinol-cytochrome C reductase cytochrome B subunit QcrB SW:QCRB_STRLI (Q9ZFB6) (549 aa) fasta scores: E(): 2.2e-88, 47.32% id in 486 aa; ubiquinol-cytochrome C reductase cytochrome B subunit complement(1657014..1658636) Corynebacterium diphtheriae NCTC 13129 2648670 NP_939967.1 CDS qcrA NC_002935.2 1658633 1659853 R Similar to Corynebacterium glutamicum iron-sulfur protein QcrA TR:Q9F482 (EMBL:AB047851) (392 aa) fasta scores: E(): 5.7e-128, 76.78% id in 392 aa, and to Mycobacterium tuberculosis ubiquinol-cytochrome C reductase iron-sulfur subunit QcrA or Rv2195 or MT2251 or MTCY190.06 SW:QCRA_MYCTU (Q10387) (429 aa) fasta scores: E(): 4.9e-37, 51.13% id in 395 aa; ubiquinol-cytochrome C reductase iron-sulfur protein complement(1658633..1659853) Corynebacterium diphtheriae NCTC 13129 2648671 NP_939968.1 CDS qcrC NC_002935.2 1659850 1660695 R Similar to Corynebacterium glutamicum cytochrome CC1 subunit QcrC TR:Q9F483 (EMBL:AB047851) (283 aa) fasta scores: E(): 1.9e-86, 81.36% id in 279 aa, and to Mycobacterium tuberculosis ubiquinol-cytochrome C reductase cytochrome C subunit QcrC or Rv2194 or MT2250 or MTCY190.05 SW:QCRC_MYCTU (Q10386) (280 aa) fasta scores: E(): 3.5e-29, 60.43% id in 278 aa; ubiquinol-cytochrome C reductase cytochrome C subunit complement(1659850..1660695) Corynebacterium diphtheriae NCTC 13129 2648672 NP_939969.1 CDS ctaE NC_002935.2 1660829 1661446 R Similar to Corynebacterium glutamicum cytochrome AA3 oxidase subunit III CtaE TR:Q9AEL8 (EMBL:AJ306418) (205 aa) fasta scores: E(): 9.9e-67, 81.95% id in 205 aa, and to Mycobacterium tuberculosis probable cytochrome C oxidase polypeptide III CtaE or Rv2193 or MT2249 or MTCY190.04 SW:COX3_MYCTU (Q10385) (203 aa) fasta scores: E(): 3.6e-47, 60% id in 205 aa; cytochrome C oxidase subunit III complement(1660829..1661446) Corynebacterium diphtheriae NCTC 13129 2648673 NP_939970.1 CDS DIP1628 NC_002935.2 1661984 1662415 R Similar to Mycobacterium leprae membrane protein ML0876 TR:Q9CCF0 (EMBL:AL583920) (139 aa) fasta scores: E(): 6.6e-13, 34.93% id in 146 aa; hypothetical protein complement(1661984..1662415) Corynebacterium diphtheriae NCTC 13129 2648674 NP_939971.1 CDS DIP1629 NC_002935.2 1662439 1663527 R Similar to Mycobacterium tuberculosis probable cytochrome C oxidase polypeptide II precursor CtaC or Rv2200c or MT2256 or MTCY190.11c SW:COX2_MYCTU (Q10375) (363 aa) fasta scores: E(): 3.5e-59, 47.55% id in 347 aa, and to Bacillus subtilis cytochrome C oxidase polypeptide II precursor CtaC SW:COX2_BACSU (P24011) (356 aa) fasta scores: E(): 2.1e-07, 24.61% id in 321 aa; cytochrome C oxidase complement(1662439..1663527) Corynebacterium diphtheriae NCTC 13129 2648675 NP_939972.1 CDS asnB NC_002935.2 1663954 1665876 D Highly similar to Corynebacterium glutamicum LtsA TR:Q9LCB7 (EMBL:AB029550) (640 aa) fasta scores: E(): 0, 83.9% id in 640 aa, and to Bacillus subtilis asparagine synthetase [glutamine-hydrolyzing] 1 AsnB or Asn SW:ASNB_BACSU (P54420) (632 aa) fasta scores: E(): 2.8e-111, 49.76% id in 631 aa; asparagine synthetase 1663954..1665876 Corynebacterium diphtheriae NCTC 13129 2648676 NP_939973.1 CDS DIP1631 NC_002935.2 1665967 1666311 R Similar to Corynebacterium glutamicum ORF1 TR:Q9LCB6 (EMBL:AB029550) (114 aa) fasta scores: E(): 3.2e-36, 84.21% id in 114 aa, and to Escherichia coli hypothetical protein YadR or B0156 or Z0167 or ECS0160 SW:YADR_ECOLI (P37026) (114 aa) fasta scores: E(): 7.2e-15, 44.66% id in 103 aa; hypothetical protein complement(1665967..1666311) Corynebacterium diphtheriae NCTC 13129 2648677 NP_939974.1 CDS DIP1632 NC_002935.2 1666530 1667204 D Similar to Streptomyces coelicolor integral membrane protein SC5F7.32 TR:Q9S2R7 (EMBL:AL096872) (251 aa) fasta scores: E(): 4.8e-10, 30.45% id in 220 aa; hypothetical protein 1666530..1667204 Corynebacterium diphtheriae NCTC 13129 2648678 NP_939975.1 CDS cobU NC_002935.2 1667205 1667753 D Similar to Mycobacterium tuberculosis cobinamide kinase CobU or Rv0254c or MTV034.20 TR:O53676 (EMBL:AL021929) (174 aa) fasta scores: E(): 6.7e-21, 44.38% id in 178 aa, and to Escherichia coli, and bifunctional cobalamin biosynthesis protein CobU [includes: cobinamide kinase; cobinamide phosphate guanylyltransferase] or B1993 or Z3153 or ECS2788 SW:COBU_ECOLI (P46886) (181 aa) fasta scores: E(): 1.8e-13, 35.48% id in 186 aa; cobinamide kinase 1667205..1667753 Corynebacterium diphtheriae NCTC 13129 2648679 NP_939976.1 CDS cobT NC_002935.2 1667803 1668873 D catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 1667803..1668873 Corynebacterium diphtheriae NCTC 13129 2648680 NP_939977.1 CDS cobS NC_002935.2 1668881 1669705 D catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole; cobalamin synthase 1668881..1669705 Corynebacterium diphtheriae NCTC 13129 2648681 NP_939978.1 CDS ilvE NC_002935.2 1669782 1670897 R catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase complement(1669782..1670897) Corynebacterium diphtheriae NCTC 13129 2648682 NP_939979.1 CDS DIP1637 NC_002935.2 1670998 1672500 D catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase 1670998..1672500 Corynebacterium diphtheriae NCTC 13129 2648683 NP_939980.1 CDS DIP1638 NC_002935.2 1672564 1672980 R Similar to Saccharopolyspora erythraea ORF1, 5' end; NADH-ferredoxin oxidoreductase (fragment) TR:Q54100 (EMBL:L38646) (93 aa) fasta scores: E(): 1.9e-08, 42.16% id in 83 aa; oxidoreductase complement(1672564..1672980) Corynebacterium diphtheriae NCTC 13129 2648684 NP_939981.1 CDS aceF NC_002935.2 1673085 1675034 D E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains; dihydrolipoamide acetyltransferase 1673085..1675034 Corynebacterium diphtheriae NCTC 13129 2648685 NP_939982.1 CDS lipB NC_002935.2 1675151 1675903 D lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B 1675151..1675903 Corynebacterium diphtheriae NCTC 13129 2648686 NP_939983.1 CDS lipA NC_002935.2 1675956 1677044 D catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 1675956..1677044 Corynebacterium diphtheriae NCTC 13129 2648687 NP_939984.1 CDS DIP1642 NC_002935.2 1677107 1677880 D Similar to Mycobacterium tuberculosis hypothetical 26.9 kDa protein Rvv2219 precursor or MT2276 or MTCY190.30 SW:YM19_MYCTU (Q10405) (250 aa) fasta scores: E(): 2.4e-36, 42.8% id in 250 aa; hypothetical protein 1677107..1677880 Corynebacterium diphtheriae NCTC 13129 2648688 NP_939985.1 CDS DIP1643 NC_002935.2 1677927 1678433 R Similar to Streptomyces coelicolor integral membrane protein SC3H12.05c TR:Q9S2N9 (EMBL:AL355740) (155 aa) fasta scores: E(): 6.1e-16, 43.04% id in 151 aa; hypothetical protein complement(1677927..1678433) Corynebacterium diphtheriae NCTC 13129 2648689 NP_939986.1 CDS glnA1 NC_002935.2 1678597 1680033 D Similar to Corynebacterium glutamicum glutamine synthetase I GlnA TR:O32354 (EMBL:Y13221) (477 aa) fasta scores: E(): 6.8e-157, 79.49% id in 478 aa, and to Streptomyces coelicolor glutamine synthetase GlnA or SC3H12.06 SW:GLNA_STRCO (P15106) (469 aa) fasta scores: E(): 3.6e-128, 66.31% id in 475 aa. Also similar to DIP1671, glnA2 (456 aa); fasta scores: E(): 5e-31, 32.353% identity in 476 aa overlap; glutamine synthetase 1678597..1680033 Corynebacterium diphtheriae NCTC 13129 2648690 NP_939987.1 CDS DIP1645 NC_002935.2 1680222 1680482 D hypothetical protein 1680222..1680482 Corynebacterium diphtheriae NCTC 13129 2648691 NP_939988.1 CDS DIP1646 NC_002935.2 1680647 1681126 D Similar to Caulobacter crescentus hypothetical protein CC3515 TR:Q9A2P1 (EMBL:AE006010) (188 aa) fasta scores: E(): 7.7e-06, 31.200% id in 125 aa; hypothetical protein 1680647..1681126 Corynebacterium diphtheriae NCTC 13129 2648692 NP_939989.1 CDS DIP1647 NC_002935.2 1681123 1681500 D hypothetical protein 1681123..1681500 Corynebacterium diphtheriae NCTC 13129 2648693 NP_939990.1 CDS DIP1650 NC_002935.2 1683094 1683417 R hypothetical protein complement(1683094..1683417) Corynebacterium diphtheriae NCTC 13129 2648695 NP_939991.1 CDS DIP1651 NC_002935.2 1683728 1684663 R Similar to Neisseria meningitidis hypothetical protein NMB0234 TR:Q9K1C8 (EMBL:AE002381) (179 aa) fasta scores: E(): 0.00039, 28.313% id in 166 aa; hypothetical protein complement(1683728..1684663) Corynebacterium diphtheriae NCTC 13129 2648696 NP_939992.1 CDS DIP1652 NC_002935.2 1684673 1688437 R Similar to Streptomyces coelicolor secreted protein SC2G5.19 TR:Q9Z5A4 (EMBL:AL035478) (1156 aa) fasta scores: E(): 7.4e-51, 32.373% id in 1041 aa; hypothetical protein complement(1684673..1688437) Corynebacterium diphtheriae NCTC 13129 2648697 NP_939993.1 CDS DIP1653 NC_002935.2 1688451 1689344 R hypothetical protein complement(1688451..1689344) Corynebacterium diphtheriae NCTC 13129 2648698 NP_939994.1 CDS DIP1654 NC_002935.2 1689384 1690178 R Weak similarity to C-terminus of Corynebacterium glutamicum PS1 protein precursor Csp1 SW:CSP1_CORGL (Q01377) (657 aa) fasta scores: E(): 4.3e-06, 26.943% id in 193 aa; hypothetical protein complement(1689384..1690178) Corynebacterium diphtheriae NCTC 13129 2648699 NP_939995.1 CDS DIP1655 NC_002935.2 1690224 1690688 R Weak similarity to C-terminus of Corynebacterium glutamicum PS1 protein precursor Csp1 SW:CSP1_CORGL (Q01377) (657 aa) fasta scores: E(): 1.7e-07, 40.196% id in 102 aa; hypothetical protein complement(1690224..1690688) Corynebacterium diphtheriae NCTC 13129 2648700 NP_939996.1 CDS DIP1656 NC_002935.2 1691457 1693697 D Similar to Helicobacter pylori hypothetical 88.8 kDa protein HP1142 TR:O25761 (EMBL:AE000620) (759 aa) fasta scores: E(): 1.7e-53, 29.896% id in 766 aa, and to Staphylococcus aureus hypothetical 50.1 kDa protein TR:BAB47139 (EMBL:AB047239) (422 aa) fasta scores: E(): 1.4e-05, 24.340% id in 341 aa; hypothetical protein 1691457..1693697 Corynebacterium diphtheriae NCTC 13129 2648701 NP_939997.1 CDS DIP1657 NC_002935.2 1693807 1694001 D hypothetical protein 1693807..1694001 Corynebacterium diphtheriae NCTC 13129 2648702 NP_939998.1 CDS DIP1658 NC_002935.2 1694157 1695038 R hypothetical protein complement(1694157..1695038) Corynebacterium diphtheriae NCTC 13129 2648703 NP_939999.1 CDS DIP1659 NC_002935.2 1695397 1696269 R hypothetical protein complement(1695397..1696269) Corynebacterium diphtheriae NCTC 13129 2648704 NP_940000.1 CDS DIP1660 NC_002935.2 1696679 1696888 R Similar to Agrobacterium tumefaciens AGR_C_1429p AGR_C_1429 TR:AAK86591 (EMBL:AE008011) (63 aa) fasta scores: E(): 0.0028, 45.283% id in 53 aa, and to Streptococcus pyogenes hypothetical protein SPY1261 TR:Q99ZE6 (EMBL:AE006565) (66 aa) fasta scores: E(): 0.0045, 37.931% id in 58 aa, and to Rhizobium meliloti hypothetical 10.1 kDa protein SMA2071 TR:AAK65789 (EMBL:AE007299) (96 aa) fasta scores: E(): 0.0053, 46.154% id in 52 aa, and to Staphylococcus aureus subspaureus N315. sigmaB-controlled gene product CsbD or SA1452 TR:Q99TM4 (EMBL:AP003134) (60 aa) fasta scores: E(): 0.0065, 38.983% id in 59 aa; hypothetical protein complement(1696679..1696888) Corynebacterium diphtheriae NCTC 13129 2648705 NP_940001.1 CDS DIP1661 NC_002935.2 1697001 1698353 R Similar to Neisseria meningitidis integral membrane protein NMA0370 TR:Q9JWH5 (EMBL:AL162753) (462 aa) fasta scores: E(): 8.6e-89, 59.488% id in 469 aa, and to Pasteurella multocida hypothetical protein PM0989 TR:Q9CM54 (EMBL:AE006138) (452 aa) fasta scores: E(): 3.3e-82, 52.402% id in 458 aa; hypothetical protein complement(1697001..1698353) Corynebacterium diphtheriae NCTC 13129 2648706 NP_940002.1 CDS DIP1662 NC_002935.2 1698485 1699168 D Similar to Streptomyces coelicolor GntR-family transcriptional regulator SCGD3.11c TR:Q9XA67 (EMBL:AL096822) (216 aa) fasta scores: E(): 3e-22, 35.122% id in 205 aa, and to Rhizobium meliloti GntR-family transcriptional regulator SMA0065 TR:AAK64690 (EMBL:AE007198) (230 aa) fasta scores: E(): 6.1e-11, 29.293% id in 198 aa; GntR family transcriptional regulator 1698485..1699168 Corynebacterium diphtheriae NCTC 13129 2648707 NP_940003.1 CDS DIP1663 NC_002935.2 1699190 1700449 D Similar to Streptomyces viridifaciens valanimycin resistant protein VlmF TR:Q9LA76 (EMBL:AF148322) (402 aa) fasta scores: E(): 2.2e-10, 28.186% id in 408 aa, and to Pseudomonas aeruginosa probable MFS transporter PA5282 TR:Q9HTS2 (EMBL:AE004940) (389 aa) fasta scores: E(): 2.7e-06, 27.877% id in 391 aa; MFS family transporter 1699190..1700449 Corynebacterium diphtheriae NCTC 13129 2648708 NP_940004.1 CDS DIP1664 NC_002935.2 1700446 1700982 R Similar to Streptomyces coelicolor Mut-like protein 2SCG2.26c TR:Q9EX27 (EMBL:AL445963) (159 aa) fasta scores: E(): 1.3e-15, 46.7% id in 167 aa; hypothetical protein complement(1700446..1700982) Corynebacterium diphtheriae NCTC 13129 2648709 NP_940005.1 CDS DIP1665 NC_002935.2 1701013 1701159 R Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein complement(1701013..1701159) Corynebacterium diphtheriae NCTC 13129 2648710 NP_940006.1 CDS thrC NC_002935.2 1701262 1702710 R catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase complement(1701262..1702710) Corynebacterium diphtheriae NCTC 13129 2648711 NP_940007.1 CDS DIP1667 NC_002935.2 1702727 1703674 D hypothetical protein 1702727..1703674 Corynebacterium diphtheriae NCTC 13129 2648712 NP_940008.1 CDS DIP1668 NC_002935.2 1703671 1703940 R hypothetical protein complement(1703671..1703940) Corynebacterium diphtheriae NCTC 13129 2648713 NP_940009.1 CDS hmuO NC_002935.2 1704009 1704656 R Almost identical to previously sequenced as Corynebacterium diphtheriae heme oxygenase HmuO SW:HMUO_CORDI (P71119) (215 aa) fasta scores: E(): 3.8e-78, 97.67% id in 215 aa; heme oxygenase complement(1704009..1704656) Corynebacterium diphtheriae NCTC 13129 2648714 NP_940010.1 CDS glnE NC_002935.2 1704796 1707960 R catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase complement(1704796..1707960) Corynebacterium diphtheriae NCTC 13129 2648715 NP_940011.1 CDS glnA2 NC_002935.2 1708011 1709351 R Similar to Corynebacterium glutamicum glutamine synthetase II GlnA2 TR:Q9AEL4 (EMBL:AJ310086) (427 aa) fasta scores: E(): 4.4e-141, 78.4% id in 426 aa, and to Bacillus subtilis glutamine synthetase GlnA SW:GLNA_BACSU (P12425) (443 aa) fasta scores: E(): 1.3e-69, 44.62% id in 437 aa. Note: Also similar to DIP1644 (478 aa); fasta scores: E(): 9.9e-32; 32.353% identity in 476 aa overlap; glutamine synthetase complement(1708011..1709351) Corynebacterium diphtheriae NCTC 13129 2648716 NP_940012.1 CDS DIP1672 NC_002935.2 1709494 1711068 D Similar to Mycobacterium tuberculosis hypothetical 56.3 kDa protein Rv2226 or MT2285 or MTCY427.07 SW:YM26_MYCTU (Q10510) (513 aa) fasta scores: E(): 2.6e-38, 34.64% id in 534 aa; hypothetical protein 1709494..1711068 Corynebacterium diphtheriae NCTC 13129 2648717 NP_940013.1 CDS DIP1673 NC_002935.2 1711078 1711269 R Low similarity to Streptomyces coelicolor hypothetical 10.4 kDa protein SCC75A.11c TR:Q9RKR3 (EMBL:AL133220) (92 aa) fasta scores: E(): 0.00053, 39.28% id in 56 aa; hypothetical protein complement(1711078..1711269) Corynebacterium diphtheriae NCTC 13129 2648718 NP_940014.1 CDS DIP1674 NC_002935.2 1711326 1712669 D Very low similarity to Homo sapiens galactokinase GalK1 or GalK SW:GAL1_HUMAN (P51570) blast scores: E(): 3e-05, score: 51 24% id; hypothetical protein 1711326..1712669 Corynebacterium diphtheriae NCTC 13129 2648719 NP_940015.1 CDS DIP1677 NC_002935.2 1714046 1714753 R hypothetical protein complement(1714046..1714753) Corynebacterium diphtheriae NCTC 13129 2648722 NP_940016.1 CDS DIP1678 NC_002935.2 1715369 1716502 R Similar to Mycobacterium leprae hypothetical 39.8 kDa protein ML1637 or MLCB1243.38 TR:O69483 (EMBL:AL023635) (371 aa) fasta scores: E(): 1.8e-73, 54.61% id in 379 aa; bifunctional RNase H/acid phosphatase complement(1715369..1716502) Corynebacterium diphtheriae NCTC 13129 2648723 NP_940017.1 CDS DIP1679 NC_002935.2 1716502 1717218 R Low similarity to Mycobacterium tuberculosis hypothetical 26.9 kDa protein Rv2229c or MT2288 or MTCY427.10c SW:YM29_MYCTU (Q10513) (245 aa) fasta scores: E(): 1.9e-06, 23.75% id in 240 aa; hypothetical protein complement(1716502..1717218) Corynebacterium diphtheriae NCTC 13129 2648724 NP_940018.1 CDS DIP1680 NC_002935.2 1717298 1718434 R Similar to Mycobacterium leprae hypothetical 40.3 kDa protein ML1639 or MLCB1243.36 TR:O69481 (EMBL:AL023635) (385 aa) fasta scores: E(): 4.3e-74, 54.27% id in 374 aa; hypothetical protein complement(1717298..1718434) Corynebacterium diphtheriae NCTC 13129 2648725 NP_940019.1 CDS DIP1681 NC_002935.2 1718437 1719471 R Similar to Mycobacterium tuberculosis aminotransferase Rv2231c or MT2290 or MTCY427.12c SW:YM31_MYCTU (Q10503) (364 aa) fasta scores: E(): 1.7e-50, 45.67% id in 335 aa and to Salmonella typhimurium CobD TR:P97084 (EMBL:U90625) (364 aa) fasta scores: E(): 3.6e-18, 27.76% id in 335 aa; hypothetical protein complement(1718437..1719471) Corynebacterium diphtheriae NCTC 13129 2648726 NP_940020.1 CDS DIP1682 NC_002935.2 1719502 1720146 D Similar to Alcaligenes eutrophus phosphoglycolate phosphatase, chromosomal CbbZC SW:GPHC_ALCEU (P40852) (231 aa) fasta scores: E(): 3.5e-08, 30.85% id in 188 aa; phosphoglycolate phosphatase 1719502..1720146 Corynebacterium diphtheriae NCTC 13129 2650272 NP_940021.1 CDS DIP1683 NC_002935.2 1720169 1720630 D Similar to Streptomyces coelicolor low molecular weight protein-tyrosine-phosphatase PtpA or SCQ11.04c SW:PTPA_STRCO (P53433) (164 aa) fasta scores: E(): 1.3e-21, 47.43% id in 156 aa, and to Bos taurus low molecular weight phosphotyrosine protein phosphatase Acp1 SW:PPAC_BOVIN (P11064) (157 aa) fasta scores: E(): 9.2e-12, 35.55% id in 135 aa; low molecular weight protein-tyrosine-phosphatase 1720169..1720630 Corynebacterium diphtheriae NCTC 13129 2650273 NP_940022.1 CDS DIP1684 NC_002935.2 1720659 1721492 D Similar to Mycobacterium tuberculosis hypothetical 29.8 kDa protein Rv2235 precursor or MT2294 or MTCY427.16 SW:YM35_MYCTU (Q10517) (271 aa) fasta scores: E(): 1.4e-34, 38.54% id in 275 aa; hypothetical protein 1720659..1721492 Corynebacterium diphtheriae NCTC 13129 2650274 NP_940023.1 CDS DIP1685 NC_002935.2 1721486 1722388 R Similar to Streptomyces coelicolor cobalamin biosynthesis protein CobD TR:Q9RJ21 (EMBL:AL132644) (327 aa) fasta scores: E(): 3.7e-39, 44.8% id in 308 aa, and to Rhodobacter capsulatus cobalamin biosynthesis protein CobD or BluD SW:COBD_RHOCA (Q52683) (314 aa) fasta scores: E(): 2.4e-23, 33.44% id in 311 aa; cobalamin biosynthesis protein complement(1721486..1722388) Corynebacterium diphtheriae NCTC 13129 2650275 NP_940024.1 CDS DIP1686 NC_002935.2 1722618 1723055 R Similar to Mycobacterium leprae hypothetical 15.2 kDa protein ML1649 or MLCB1243.26 TR:O69479 (EMBL:AL023635) (140 aa) fasta scores: E(): 4.1e-24, 56.55% id in 122 aa; hypothetical protein complement(1722618..1723055) Corynebacterium diphtheriae NCTC 13129 2650277 NP_940025.1 CDS aceE NC_002935.2 1723276 1726011 D E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 1723276..1726011 Corynebacterium diphtheriae NCTC 13129 2650278 NP_940026.1 CDS DIP1688 NC_002935.2 1726207 1726770 D Similar to Streptomyces coelicolor secreted protein SCJ1.02c TR:Q9RJ12 (EMBL:AL109962) (195 aa) fasta scores: E(): 4.6e-25, 44.69% id in 179 aa; hypothetical protein 1726207..1726770 Corynebacterium diphtheriae NCTC 13129 2650279 NP_940027.1 CDS DIP1689 NC_002935.2 1726799 1729045 R Similar to Mycobacterium tuberculosis CDC1551 lipopolysaccharide biosynthesis protein WbpC, MT1616 TR:AAK45883 (EMBL:AE007027) (729 aa) fasta scores: E(): 8.2e-42, 34.25% id in 762 aa; hypothetical protein complement(1726799..1729045) Corynebacterium diphtheriae NCTC 13129 2650280 NP_940028.1 CDS DIP1690 NC_002935.2 1729135 1730457 D Similar to Mycobacterium leprae hypothetical 50.2 kDa protein ML1338 or MLC1351.25 TR:O05686 (EMBL:Z95117) (440 aa) fasta scores: E(): 1.8e-11, 29.77% id in 393 aa; hypothetical protein 1729135..1730457 Corynebacterium diphtheriae NCTC 13129 2650281 NP_940029.1 CDS DIP1691 NC_002935.2 1730402 1731367 R Similar to Mycobacterium tuberculosis CDC1551 hydrolase, alpha/beta hydrolase fold family MT3260 TR:AAK47599 (EMBL:AE007139) (323 aa) fasta scores: E(): 3.5e-10, 29.32% id in 324 aa; alpha/beta hydrolase complement(1730402..1731367) Corynebacterium diphtheriae NCTC 13129 2650282 NP_940030.1 CDS DIP1692 NC_002935.2 1731464 1731721 D Similar to Thermotoga maritima acyl carrier protein TM0662 TR:Q9WZD0 (EMBL:AE001739) (81 aa) fasta scores: E(): 0.0012, 32.05% id in 78 aa, and to Bacillus halodurans acyl carrier protein AcpA or BH2490 SW:ACP_BACHD (Q9KA04) (77 aa) fasta scores: E(): 0.0062, 32.87% id in 73 aa; acyl carrier protein 1731464..1731721 Corynebacterium diphtheriae NCTC 13129 2650283 NP_940031.1 CDS DIP1693 NC_002935.2 1731758 1732567 D Similar to Streptomyces coelicolor conserved hypothetical protein SCE20.17c TR:Q9RDA8 (EMBL:AL136058) (259 aa) fasta scores: E(): 4.9e-62, 65.86% id in 249 aa, and to Escherichia coli NagD protein or B0675 or Z0822 or ECS0705 SW:NAGD_ECOLI (P15302) (250 aa) fasta scores: E(): 1e-37, 43.02% id in 251 aa; N-acetylglucosamine-like protein 1731758..1732567 Corynebacterium diphtheriae NCTC 13129 2650284 NP_940032.1 CDS DIP1694 NC_002935.2 1732564 1732932 R hypothetical protein complement(1732564..1732932) Corynebacterium diphtheriae NCTC 13129 2650285 NP_940033.1 CDS DIP1695 NC_002935.2 1733031 1733852 R Similar to Streptomyces coelicolor hypothetical 28.7 kDa protein SC4A7.08 TR:Q9RDQ4 (EMBL:AL133423) (273 aa) fasta scores: E(): 1.3e-49, 50.19% id in 259 aa; hypothetical protein complement(1733031..1733852) Corynebacterium diphtheriae NCTC 13129 2650286 NP_940034.1 CDS DIP1696 NC_002935.2 1733849 1734676 R Similar to Streptomyces coelicolor hypothetical protein SC2A11.15 SW:YU26_STRCO (O86576) (219 aa) fasta scores: E(): 8.3e-14, 32.68% id in 205 aa; hypothetical protein complement(1733849..1734676) Corynebacterium diphtheriae NCTC 13129 2650287 NP_940035.1 CDS DIP1697 NC_002935.2 1735145 1735387 D Similar to Mycobacterium tuberculosis CDC1551 hypothetical 10.3 kDa protein MT2407 TR:AAK46700 (EMBL:AE007081) (97 aa) fasta scores: E(): 2.2e-05, 46.42% id in 56 aa; hypothetical protein 1735145..1735387 Corynebacterium diphtheriae NCTC 13129 2650290 NP_940036.1 CDS DIP1698 NC_002935.2 1735479 1736036 D Similar to Corynebacterium glutamicum thiamine biosynthesis protein X ThiX SW:THIX_CORGL (P42461) (133 aa) fasta scores: E(): 2.5e-12, 38.09% id in 126 aa; thiamine biosynthesis-like protein 1735479..1736036 Corynebacterium diphtheriae NCTC 13129 2650291 NP_940037.1 CDS dnaG NC_002935.2 1736085 1737983 R synthesizes RNA primers at the replication forks; DNA primase complement(1736085..1737983) Corynebacterium diphtheriae NCTC 13129 2650292 NP_940038.1 CDS glmS NC_002935.2 1737994 1739871 R Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase complement(1737994..1739871) Corynebacterium diphtheriae NCTC 13129 2650293 NP_940039.1 CDS DIP1701 NC_002935.2 1739962 1740420 D Similar to Streptomyces aureofaciens guanyl-specific ribonuclease SA3 precursor RNAse3 SW:RNS3_STRAU (P30289) (141 aa) fasta scores: E(): 1.7e-10, 42.14% id in 140 aa; ribonuclease 1739962..1740420 Corynebacterium diphtheriae NCTC 13129 2650294 NP_940040.1 CDS DIP1702 NC_002935.2 1740467 1740649 D hypothetical protein 1740467..1740649 Corynebacterium diphtheriae NCTC 13129 2650295 NP_940041.1 CDS DIP1703 NC_002935.2 1740639 1741910 R dGTPase type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase-like protein complement(1740639..1741910) Corynebacterium diphtheriae NCTC 13129 2650296 NP_940042.1 CDS DIP1704 NC_002935.2 1741917 1742594 R hypothetical protein complement(1741917..1742594) Corynebacterium diphtheriae NCTC 13129 2650297 NP_940043.1 CDS DIP1705 NC_002935.2 1742648 1744654 D Similar to Mycobacterium tuberculosis hypothetical 70.0 kDa protein Rv2345 or MTCY98.14 TR:P95241 (EMBL:Z83860) (660 aa) fasta scores: E(): 1.6e-41, 30.4% id in 671 aa; hypothetical protein 1742648..1744654 Corynebacterium diphtheriae NCTC 13129 2650298 NP_940044.1 CDS DIP1706 NC_002935.2 1744651 1745049 R hypothetical protein complement(1744651..1745049) Corynebacterium diphtheriae NCTC 13129 2650299 NP_940045.1 CDS DIP1707 NC_002935.2 1745055 1745582 R hypothetical protein complement(1745055..1745582) Corynebacterium diphtheriae NCTC 13129 2650300 NP_940046.1 CDS glyS NC_002935.2 1745608 1746993 R Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase complement(1745608..1746993) Corynebacterium diphtheriae NCTC 13129 2650301 NP_940047.1 CDS DIP1709 NC_002935.2 1747304 1747681 D Similar to Mycobacterium leprae ArsR-family transcriptional regulator ML0825 TR:Q9CCG5 (EMBL:AL583919) (140 aa) fasta scores: E(): 8.8e-08, 44.7% id in 85 aa, and to Sinorhizobium spAs4. ArsR TR:Q9RA93 (EMBL:AF178758) (115 aa) fasta scores: E(): 3.4e-05, 34.04% id in 94 aa; ArsR family transcriptional regulator 1747304..1747681 Corynebacterium diphtheriae NCTC 13129 2650302 NP_940048.1 CDS DIP1710 NC_002935.2 1747858 1748286 D Similar to Mycobacterium tuberculosis CDC1551 ferric uptake regulation protein MT2428 TR:AAK46722 (EMBL:AE007082) (130 aa) fasta scores: E(): 6.1e-24, 53.6% id in 125 aa, and to Escherichia coli ferric uptake regulation protein Fur or B0683 or Z0831 or ECS0714 SW:FUR_ECOLI (P06975) (148 aa) fasta scores: E(): 2.4e-10, 29.77% id in 131 aa; ferric uptake regulatory protein 1747858..1748286 Corynebacterium diphtheriae NCTC 13129 2650303 NP_940049.1 CDS DIP1711 NC_002935.2 1748293 1749288 R Similar to Pseudomonas aeruginosa hypothetical protein PA3851 TR:Q9HXF5 (EMBL:AE004802) (250 aa) fasta scores: E(): 9.2e-22, 38.29% id in 235 aa, and to Pyrococcus abyssi hypothetical 40.7 kDa protein PAB1273 TR:Q9UY73 (EMBL:AJ248288) (364 aa) fasta scores: E(): 1.3e-12, 28.69% id in 345 aa; hypothetical protein complement(1748293..1749288) Corynebacterium diphtheriae NCTC 13129 2650304 NP_940050.1 CDS DIP1712 NC_002935.2 1749363 1750100 R catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase complement(1749363..1750100) Corynebacterium diphtheriae NCTC 13129 2650305 NP_940051.1 CDS recO NC_002935.2 1750120 1750848 R involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO complement(1750120..1750848) Corynebacterium diphtheriae NCTC 13129 2650306 NP_940052.1 CDS era NC_002935.2 1750848 1751765 R Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era complement(1750848..1751765) Corynebacterium diphtheriae NCTC 13129 2650307 NP_940053.1 CDS DIP1715 NC_002935.2 1751817 1752677 R catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxamine kinase complement(1751817..1752677) Corynebacterium diphtheriae NCTC 13129 2650308 NP_940054.1 CDS DIP1716 NC_002935.2 1752679 1754007 R Similar to Mycobacterium tuberculosis hypothetical 47.2 kDa protein Rv2366c or MT2435 or MTCY27.14 SW:YN66_MYCTU (O05832) (435 aa) fasta scores: E(): 1.1e-67, 53.91% id in 434 aa; hypothetical protein complement(1752679..1754007) Corynebacterium diphtheriae NCTC 13129 2650309 NP_940055.1 CDS DIP1717 NC_002935.2 1754004 1754594 R Similar to Mycobacterium tuberculosis hypothetical 19.7 kDa protein Rv2367c or MT2436 or MTCY27.13 SW:YN67_MYCTU (O05831) (177 aa) fasta scores: E(): 4.7e-40, 69.33% id in 150 aa; metalloprotease complement(1754004..1754594) Corynebacterium diphtheriae NCTC 13129 2650310 NP_940056.1 CDS DIP1718 NC_002935.2 1754595 1755563 R Similar to Mycobacterium tuberculosis PhoH-like protein Rv2368c or MT2437 or MTCY27.12 SW:PHOL_MYCTU (O05830) (352 aa) fasta scores: E(): 2.2e-66, 63.25% id in 313 aa, and to Bacillus subtilis PhoH-like protein PhoH SW:PHOL_BACSU (P46343) (319 aa) fasta scores: E(): 2.9e-52, 52.47% id in 303 aa; PhoH-like protein complement(1754595..1755563) Corynebacterium diphtheriae NCTC 13129 2650311 NP_940057.1 CDS DIP1719 NC_002935.2 1755611 1756369 R in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE complement(1755611..1756369) Corynebacterium diphtheriae NCTC 13129 2650312 NP_940058.1 CDS dnaJ2 NC_002935.2 1756371 1757498 R chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ complement(1756371..1757498) Corynebacterium diphtheriae NCTC 13129 2650313 NP_940059.1 CDS hrcA NC_002935.2 1757572 1758609 R Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons; heat-inducible transcription repressor complement(1757572..1758609) Corynebacterium diphtheriae NCTC 13129 2650314 NP_940060.1 CDS hemN NC_002935.2 1758649 1759782 R catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase complement(1758649..1759782) Corynebacterium diphtheriae NCTC 13129 2650315 NP_940061.1 CDS DIP1723 NC_002935.2 1759772 1760443 R hypothetical protein complement(1759772..1760443) Corynebacterium diphtheriae NCTC 13129 2650316 NP_940062.1 CDS DIP1724 NC_002935.2 1760582 1763809 R No significant database matches. Note: Contains a potential sortase anchor site (LANTG) upstream of the C-terminal region transmembrane domain. Contains also a twin-arginine translocation (TAT) system recognition motif (RRVFAS) at the N-terminal region. Also similar to DIP0439, DIP0442, DIP2325 and DIP0443; surface-anchored membrane protein complement(1760582..1763809) Corynebacterium diphtheriae NCTC 13129 2650317 NP_940063.1 CDS DIP1725 NC_002935.2 1763886 1765715 R Similar to Mycobacterium tuberculosis long-chain-fatty-acid-CoA ligase FadD15 or Rv2187 or MTV021.20 TR:O53521 (EMBL:AL021957) (600 aa) fasta scores: E(): 9.3e-80, 46.48% id in 611 aa, and to Streptomyces coelicolor long chain fatty acid CoA ligase SC6G10.04 TR:Q9X7Z0 (EMBL:AL049497) (598 aa) fasta scores: E(): 1.7e-78, 46.72% id in 610 aa; long-chain-fatty-acid-CoA ligase complement(1763886..1765715) Corynebacterium diphtheriae NCTC 13129 2650318 NP_940064.1 CDS DIP1726 NC_002935.2 1765812 1767980 D Similar to Mycobacterium tuberculosis 4-alpha-glucanotransferase MalQ or Rv1781c or MT1831 or MTV049.03c SW:MALQ_MYCTU (O53932) (724 aa) fasta scores: E(): 7.8e-73, 45.87% id in 728 aa, and to Escherichia coli 4-alpha-glucanotransferase MalQ or MalA or B3416 SW:MALQ_ECOLI (P15977) (694 aa) fasta scores: E(): 1.2e-29, 28.48% id in 660 aa; glucanotransferase 1765812..1767980 Corynebacterium diphtheriae NCTC 13129 2650319 NP_940065.1 CDS DIP1727 NC_002935.2 1768127 1768330 R hypothetical protein complement(1768127..1768330) Corynebacterium diphtheriae NCTC 13129 2650320 NP_940066.1 CDS DIP1728 NC_002935.2 1768327 1770306 R Similar to Escherichia coli peptidyl-dipeptidase Dcp or B1538 SW:DCP_ECOLI (P24171) (680 aa) fasta scores: E(): 6.5e-63, 38.52% id in 680 aa, and to Escherichia coli oligopeptidase A PrlC or OpdA or B3498 SW:OPDA_ECOLI (P27298) (680 aa) fasta scores: E(): 1.8e-37, 31.35% id in 689 aa; peptidase complement(1768327..1770306) Corynebacterium diphtheriae NCTC 13129 2650321 NP_940067.1 CDS DIP1729 NC_002935.2 1770335 1771534 D Similar to Streptomyces coelicolor carboxylesterase SC5G9.30 TR:Q9RKZ7 (EMBL:AL117385) (518 aa) fasta scores: E(): 3.2e-14, 30.57% id in 363 aa, and to Bacillus subtilis para-nitrobenzyl esterase PnbA SW:PNBA_BACSU (P37967) (489 aa) fasta scores: E(): 7.3e-12, 28.22% id in 372 aa; hydrolase 1770335..1771534 Corynebacterium diphtheriae NCTC 13129 2650322 NP_940068.1 CDS idi NC_002935.2 1771521 1772072 R catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate; isopentenyl-diphosphate delta-isomerase complement(1771521..1772072) Corynebacterium diphtheriae NCTC 13129 2650323 NP_940069.1 CDS DIP1731 NC_002935.2 1772091 1773665 R hypothetical protein complement(1772091..1773665) Corynebacterium diphtheriae NCTC 13129 2650324 NP_940070.1 CDS DIP1732 NC_002935.2 1773666 1774244 R hypothetical protein complement(1773666..1774244) Corynebacterium diphtheriae NCTC 13129 2650325 NP_940071.1 CDS DIP1733 NC_002935.2 1774501 1775658 R hypothetical protein complement(1774501..1775658) Corynebacterium diphtheriae NCTC 13129 2650326 NP_940072.1 CDS DIP1734 NC_002935.2 1775840 1776250 R hypothetical protein complement(1775840..1776250) Corynebacterium diphtheriae NCTC 13129 2650327 NP_940073.1 CDS DIP1735 NC_002935.2 1776468 1778315 D Similar to Amycolatopsis orientalis hypothetical 71.1 kDa protein PCZA363.2 CZA382.30 TR:O52818 (EMBL:AJ223999) (650 aa) fasta scores: E(): 1.8e-39, 30.58% id in 618 aa; ABC transporter ATP-binding protein 1776468..1778315 Corynebacterium diphtheriae NCTC 13129 2650328 NP_940074.1 CDS aecD NC_002935.2 1778334 1779464 D Similar to Corynebacterium glutamicum beta C-S lyase AecD TR:Q46061 (EMBL:M89931) (325 aa) fasta scores: E(): 3e-66, 53.93% id in 330 aa; beta C-S lyase 1778334..1779464 Corynebacterium diphtheriae NCTC 13129 2650329 NP_940075.1 CDS brnQ NC_002935.2 1779545 1780849 D Similar to Corynebacterium glutamicum branched-chain amino acid transport system carrier protein BrnQ SW:BRNQ_CORGL (O06754) (426 aa) fasta scores: E(): 8.7e-50, 53.09% id in 420 aa, and to Escherichia coli branched-chain amino acid transport system II carrier protein BrnQ or B0401 or Z0499 or ECS0451 SW:BRNQ_ECOLI (P37011) (439 aa) fasta scores: E(): 2.4e-40, 33.17% id in 431 aa; branched-chain amino acid ABC transport system membrane protein 1779545..1780849 Corynebacterium diphtheriae NCTC 13129 2650330 NP_940076.1 CDS DIP1738 NC_002935.2 1780859 1781812 D Similar to Agrobacterium tumefaciens StrC58 AGR_l_2217p TR:AAK89679 (EMBL:AE008310) (333 aa) fasta scores: E(): 5.1e-42, 45.79% id in 321 aa; hypothetical protein 1780859..1781812 Corynebacterium diphtheriae NCTC 13129 2650331 NP_940077.1 CDS ectP NC_002935.2 1781790 1783616 R Similar to Corynebacterium glutamicum EctP protein (Transport of ectoine, glycine betaine, proline) TR:O86143 (EMBL:AJ001436) (615 aa) fasta scores: E(): 5.2e-181, 73.23% id in 609 aa, and to Bacillus subtilis glycine betaine transporter OpuD SW:OPUD_BACSU (P54417) (512 aa) fasta scores: E(): 2.4e-65, 38.35% id in 511 aa; ectoine, glycine betaine and proline transport system membrane protein complement(1781790..1783616) Corynebacterium diphtheriae NCTC 13129 2650332 NP_940078.1 CDS DIP1740 NC_002935.2 1783772 1785298 D Similar to Rhizobium loti dipeptide-binding protein of ABC transporter MLR1186 TR:Q98L42 (EMBL:AP002996) (497 aa) fasta scores: E(): 8e-52, 34.96% id in 449 aa; ABC transporter substrate-binding protein 1783772..1785298 Corynebacterium diphtheriae NCTC 13129 2650333 NP_940079.1 CDS DIP1741 NC_002935.2 1785305 1786252 D Similar to Rhizobium loti permease of oligopeptide ABC transporter MLR1187 TR:Q98L41 (EMBL:AP002996) (315 aa) fasta scores: E(): 1.3e-43, 42.2% id in 308 aa, and to Bacillus subtilis oligopeptide transport system permease AppB SW:APPB_BACSU (P42062) (317 aa) fasta scores: E(): 2e-35, 35.93% id in 320 aa; oligopeptide ABC transport system membrane protein 1785305..1786252 Corynebacterium diphtheriae NCTC 13129 2650334 NP_940080.1 CDS DIP1742 NC_002935.2 1786256 1787077 D Similar to Rhizobium loti permease of oligopeptide ABC transporter MLR1189 TR:Q98L40 (EMBL:AP002996) (289 aa) fasta scores: E(): 1.8e-49, 52.1% id in 261 aa, and to Escherichia coli dipeptide transport system permease DppC or B3542 or Z4959 or ECS4422 SW:DPPC_ECOLI (P37315) (300 aa) fasta scores: E(): 5e-36, 42.96% id in 270 aa; oligopeptide ABC transport system membrane protein 1786256..1787077 Corynebacterium diphtheriae NCTC 13129 2649367 NP_940081.1 CDS DIP1743 NC_002935.2 1787074 1788516 D Similar to Streptomyces coelicolor oligopeptide ABC transporter ATP-binding protein SCBAC1A6.35c TR:Q9ADF2 (EMBL:AL589708) (585 aa) fasta scores: E(): 1.2e-33, 44.29% id in 526 aa; ABC transporter ATP-binding protein 1787074..1788516 Corynebacterium diphtheriae NCTC 13129 2649368 NP_940082.1 CDS DIP1744 NC_002935.2 1788659 1789873 R Similar to Streptomyces coelicolor prolyl aminopeptidase SCF43.16c TR:Q9RD72 (EMBL:AL136502) (433 aa) fasta scores: E(): 5e-44, 41.16% id in 396 aa, and to Aeromonas sobria proline iminopeptidase Pip or Pap SW:PIP_AERSO (P46547) (424 aa) fasta scores: E(): 8e-26, 40.25% id in 395 aa; prolyl aminopeptidase complement(1788659..1789873) Corynebacterium diphtheriae NCTC 13129 2649369 NP_940083.1 CDS DIP1745 NC_002935.2 1789874 1790539 D Similar to Xylella fastidiosa hypothetical protein XF1717 TR:Q9PCR1 (EMBL:AE003995) (266 aa) fasta scores: E(): 1.7e-28, 46.22% id in 225 aa; hypothetical protein 1789874..1790539 Corynebacterium diphtheriae NCTC 13129 2649370 NP_940084.1 CDS DIP1746 NC_002935.2 1790536 1791924 D Similar to Escherichia coli xylulose kinase XylB or B3564 SW:XYLB_ECOLI (P09099) (484 aa) fasta scores: E(): 6.8e-22, 30.57% id in 471 aa; xylulose kinase 1790536..1791924 Corynebacterium diphtheriae NCTC 13129 2649371 NP_940085.1 CDS DIP1747 NC_002935.2 1791955 1792185 D hypothetical protein 1791955..1792185 Corynebacterium diphtheriae NCTC 13129 2649372 NP_940086.1 CDS DIP1748 NC_002935.2 1792489 1794102 D Similar to Lactococcus lactis NADH oxidase NoxC TR:Q9CHE6 (EMBL:AE006312) (547 aa) fasta scores: E(): 5.8e-81, 44.95% id in 545 aa, and to Enterococcus faecalis NADH oxidase Nox SW:NAOX_ENTFA (P37061) (446 aa) fasta scores: E(): 3.8e-30, 27.46% id in 437 aa; oxidase 1792489..1794102 Corynebacterium diphtheriae NCTC 13129 2649373 NP_940087.1 CDS DIP1749 NC_002935.2 1794114 1794371 D Similar to Streptomyces coelicolor hypothetical 10.2 kDa protein SCF56.04c TR:Q9RD62 (EMBL:AL133424) (92 aa) fasta scores: E(): 4.6e-13, 52.22% id in 90 aa; hypothetical protein 1794114..1794371 Corynebacterium diphtheriae NCTC 13129 2649374 NP_940088.1 CDS DIP1750 NC_002935.2 1794357 1795889 R Similar to Vibrio cholerae glutathione-regulated potassium-efflux system protein KefB, VC0992 TR:Q9KTB1 (EMBL:AE004180) (528 aa) fasta scores: E(): 1.3e-37, 33.26% id in 514 aa; potassium transport related membrane protein complement(1794357..1795889) Corynebacterium diphtheriae NCTC 13129 2649375 NP_940089.1 CDS DIP1751 NC_002935.2 1795929 1796147 D hypothetical protein 1795929..1796147 Corynebacterium diphtheriae NCTC 13129 2649376 NP_940090.1 CDS DIP1752 NC_002935.2 1796249 1797652 D Similar to Lactococcus lactis multidrug transporter YqiA TR:Q9CF47 (EMBL:AE006394) (476 aa) fasta scores: E(): 1.5e-87, 58.69% id in 460 aa, and to Streptomyces glaucescens tetracenomycin C resistance and export protein TcmA SW:TCMA_STRGA (P39886) (538 aa) fasta scores: E(): 3.8e-15, 24.88% id in 422 aa; antibiotic ABC transporter 1796249..1797652 Corynebacterium diphtheriae NCTC 13129 2649377 NP_940091.1 CDS iunH NC_002935.2 1797649 1798587 D Similar to Crithidia fasciculata inosine-uridine preferring nucleoside hydrolase IunH SW:IUNH_CRIFA (Q27546) (314 aa) fasta scores: E(): 2.3e-73, 64.19% id in 310 aa; inosine-uridine preferring nucleoside hydrolase 1797649..1798587 Corynebacterium diphtheriae NCTC 13129 2649378 NP_940092.1 CDS DIP1754 NC_002935.2 1798593 1799399 D Similar to Streptomyces coelicolor integral membrane protein SC4A2.12 TR:O86668 (EMBL:AL031182) (299 aa) fasta scores: E(): 9.2e-18, 34.31% id in 271 aa; hypothetical protein 1798593..1799399 Corynebacterium diphtheriae NCTC 13129 2649379 NP_940093.1 CDS DIP1755 NC_002935.2 1799436 1800095 D hypothetical protein 1799436..1800095 Corynebacterium diphtheriae NCTC 13129 2649380 NP_940094.1 CDS DIP1756 NC_002935.2 1800239 1803019 D Similar to Neisseria meningitidis hypothetical protein NMA1791 TR:Q9JTG2 (EMBL:AL162757) (803 aa) fasta scores: E(): 1.8e-94, 40.58% id in 818 aa, and to Deinococcus radiodurans DNA modification methyltransferase-related protein DR2267 TR:Q9RS60 (EMBL:AE002059) (840 aa) fasta scores: E(): 1.8e-15, 25.93% id in 879 aa; DNA methyltransferase 1800239..1803019 Corynebacterium diphtheriae NCTC 13129 2649381 NP_940095.1 CDS DIP1757 NC_002935.2 1803016 1803906 D Similar to Mycobacterium tuberculosis CDC1551 Mrr restriction system protein MT2603 TR:AAK46913 (EMBL:AE007096) (306 aa) fasta scores: E(): 1.1e-06, 25.67% id in 261 aa, and to Escherichia coli restriction system protein Mrr or B4351 SW:MRR_ECOLI (P24202) (304 aa) fasta scores: E(): 0.015, 23.68% id in 266 aa. Note: In E.coli this ORF is involved in acceptance of foreign DNA which is modified, restricting both adenine and cytosime methylated DNA; Mrr restriction system protein 1803016..1803906 Corynebacterium diphtheriae NCTC 13129 2649382 NP_940096.1 CDS DIP1758 NC_002935.2 1803982 1804326 R Doubtful CDS. No significant database matches; hypothetical protein complement(1803982..1804326) Corynebacterium diphtheriae NCTC 13129 2649383 NP_940097.1 CDS DIP1759 NC_002935.2 1804436 1805272 R Similar to Pasteurella multocida hypothetical protein PM1540 TR:Q9CKR6 (EMBL:AE006190) (309 aa) fasta scores: E(): 3.2e-26, 35.98% id in 239 aa, and to Staphylococcus aureus hypothetical protein SAV0801 TR:BAB56963 (EMBL:AP003360) (322 aa) fasta scores: E(): 1.6e-06, 22.13% id in 244 aa; hypothetical protein complement(1804436..1805272) Corynebacterium diphtheriae NCTC 13129 2649384 NP_940098.1 CDS DIP1760 NC_002935.2 1805322 1805507 R Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein complement(1805322..1805507) Corynebacterium diphtheriae NCTC 13129 2649385 NP_940099.1 CDS DIP1761 NC_002935.2 1805784 1806617 D hypothetical protein 1805784..1806617 Corynebacterium diphtheriae NCTC 13129 2649386 NP_940100.1 CDS DIP1762 NC_002935.2 1806618 1807301 D Poor database matches. Weakly similar to Streptomyces coelicolor hypothetical protein SCI41.33c TR:O87592 (EMBL:AF086832) (196 aa) fasta scores: E(): 8.3, 24.27% id in 173 aa; hypothetical protein 1806618..1807301 Corynebacterium diphtheriae NCTC 13129 2649387 NP_940101.1 CDS DIP1763 NC_002935.2 1807896 1809062 R Similar to Corynebacterium glutamicum hypothetical protein CGL1238 SWALL:Q8NR26 (EMBL:AP005277) (383 aa) fasta scores: E(): 4.8e-30, 31.77% id in 384 aa, and to Bifidobacterium longum NCC2705 hypothetical protein BL0662 SWALL:AAN24484 (EMBL:AE014688) (368 aa) fasta scores: E(): 4.5e-20, 39.73% id in 380 aa; hypothetical protein complement(1807896..1809062) Corynebacterium diphtheriae NCTC 13129 2649388 NP_940102.1 CDS lepA NC_002935.2 1809198 1811045 R binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA complement(1809198..1811045) Corynebacterium diphtheriae NCTC 13129 2649389 NP_940103.1 CDS DIP1765 NC_002935.2 1811324 1811881 D Poor database matches. C-terminal region is similar to Mycobacterium tuberculosis hypothetical protein Rv2405 TR:P71738 (EMBL:Z81368) (189 aa) fasta scores: E(): 1.9e-22, 43.7% id in 135 aa. Possible alternative translational start site; hypothetical protein 1811324..1811881 Corynebacterium diphtheriae NCTC 13129 2649390 NP_940104.1 CDS rpsT NC_002935.2 1812042 1812305 D binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 1812042..1812305 Corynebacterium diphtheriae NCTC 13129 2649391 NP_940105.1 CDS DIP1767 NC_002935.2 1812354 1812992 R Similar to Escherichia coli threonine efflux protein RhtC SW:RHTC_ECOLI (P27846) (206 aa) fasta scores: E(): 2.7e-18, 30.43% id in 207 aa, and to Salmonella typhimurium LT2 threonine efflux protein RhtC TR:Q9L6N7 (EMBL:AF233324) (206 aa) fasta scores: E(): 1.7e-18, 30.88% id in 204 aa; LysE type translocator complement(1812354..1812992) Corynebacterium diphtheriae NCTC 13129 2649392 NP_940106.1 CDS DIP1768 NC_002935.2 1812982 1813383 R Similar to Streptomyces coelicolor ankyrin-like protein SC6D7.25 TR:Q9RKX3 (EMBL:AL133213) (134 aa) fasta scores: E(): 4.4e-23, 57.36% id in 129 aa, and to Campylobacter jejuni ankyrin-repeat containing protein Cj1386 TR:Q9PMR4 (EMBL:AL139078) (156 aa) fasta scores: E(): 1.2e-10, 39.66% id in 121 aa; hypothetical protein complement(1812982..1813383) Corynebacterium diphtheriae NCTC 13129 2649393 NP_940107.1 CDS DIP1769 NC_002935.2 1813394 1814368 R required for the assembly and function of the DNAX complex which are required fro the assembly of the beta subunit onto primed DNA; hypothetical protein complement(1813394..1814368) Corynebacterium diphtheriae NCTC 13129 2649394 NP_940108.1 CDS DIP1770 NC_002935.2 1814322 1815995 R Poor database matches. Weakly similar to Mycobacterium tuberculosis hypothetical protein Rv2414c TR:P71729 (EMBL:Z81368) (514 aa) fasta scores: E(): 7.8e-27, 33.81% id in 482 aa; hypothetical protein complement(1814322..1815995) Corynebacterium diphtheriae NCTC 13129 2649395 NP_940109.1 CDS DIP1771 NC_002935.2 1815992 1816621 R No significant database matches to the full length CDS. C-terminus is similar to the C-terminal regions of Bacillus halodurans late competence operon required for DNA binding and uptake BH1333 TR:Q9KD84 (EMBL:AP001511) (210 aa) fasta scores: E(): 0.00087, 40.55% id in 143 aa, and Streptomyces coelicolor DNA-binding protein SCC123.06c TR:Q9RDL8 (EMBL:AL136518) (355 aa) fasta scores: E(): 3e-06, 40.93% id in 193 aa; hypothetical protein complement(1815992..1816621) Corynebacterium diphtheriae NCTC 13129 2649396 NP_940110.1 CDS DIP1772 NC_002935.2 1816728 1817549 R Similar to Mycobacterium tuberculosis hypothetical protein Rv2417c TR:P71726 (EMBL:Z81368) (280 aa) fasta scores: E(): 1e-21, 34.92% id in 272 aa, and to Streptomyces coelicolor hypothetical protein SCC123.07c TR:Q9RDL7 (EMBL:AL136518) (281 aa) fasta scores: E(): 6e-21, 36.13% id in 274 aa; hypothetical protein complement(1816728..1817549) Corynebacterium diphtheriae NCTC 13129 2649397 NP_940111.1 CDS DIP1773 NC_002935.2 1817554 1818276 R Similar to Mycobacterium leprae possible phosphoglycerate mutase ML1452 TR:Q9CC00 (EMBL:AL583922) (224 aa) fasta scores: E(): 1.1e-34, 44.26% id in 244 aa, and to Mycobacterium tuberculosis hypothetical protein Rv2419c TR:P71724 (EMBL:Z81368) (223 aa) fasta scores: E(): 6.3e-34, 52.88% id in 191 aa; phosphoglycerate mutase complement(1817554..1818276) Corynebacterium diphtheriae NCTC 13129 2649398 NP_940112.1 CDS DIP1774 NC_002935.2 1818283 1818750 R Similar to Streptomyces coelicolor hypothetical protein SCC123.15c TR:Q9RDK9 (EMBL:AL136518) (148 aa) fasta scores: E(): 1.7e-21, 50.34% id in 145 aa, and to Mycobacterium tuberculosis hypothetical protein Rv2420c TR:O86327 (EMBL:Z81368) (126 aa) fasta scores: E(): 4.5e-20, 50.42% id in 117 aa; hypothetical protein complement(1818283..1818750) Corynebacterium diphtheriae NCTC 13129 2649399 NP_940113.1 CDS nadD NC_002935.2 1818773 1819459 R transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase complement(1818773..1819459) Corynebacterium diphtheriae NCTC 13129 2649400 NP_940114.1 CDS proA NC_002935.2 1819483 1820775 R Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase complement(1819483..1820775) Corynebacterium diphtheriae NCTC 13129 2649401 NP_940115.1 CDS proB NC_002935.2 1820793 1821923 R catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase complement(1820793..1821923) Corynebacterium diphtheriae NCTC 13129 2649402 NP_940116.1 CDS DIP1778 NC_002935.2 1821944 1822195 R No significant database matches. Doubtful CDS; hypothetical protein complement(1821944..1822195) Corynebacterium diphtheriae NCTC 13129 2649403 NP_940117.1 CDS obgE NC_002935.2 1822199 1823725 R essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE complement(1822199..1823725) Corynebacterium diphtheriae NCTC 13129 2649404 NP_940118.1 CDS rpmA NC_002935.2 1823886 1824152 R involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 complement(1823886..1824152) Corynebacterium diphtheriae NCTC 13129 2649405 NP_940119.1 CDS rplU NC_002935.2 1824193 1824498 R Similar to Escherichia coli 50S ribosomal protein L21 RplU SW:RL21_ECOLI (P02422) (103 aa) fasta scores: E(): 1.5e-10, 38.61% id in 101 aa, and to Mycobacterium leprae 50S ribosomal protein L21 ML1467 SW:RL21_MYCLE (Q9CBZ2) (103 aa) fasta scores: E(): 5.7e-23, 71% id in 100 aa; 50S ribosomal protein L21 complement(1824193..1824498) Corynebacterium diphtheriae NCTC 13129 2649406 NP_940120.1 CDS DIP1782 NC_002935.2 1824673 1827561 R C-terminus is similar to the N-terminal region of Escherichia coli ribonuclease E Rne SW:RNE_ECOLI (P21513) (1061 aa) fasta scores: E(): 5.5e-38, 33.08% id in 659 aa. Full length CDS is similar to Mycobacterium leprae possible ribonuclease ML1468 TR:Q9CBZ1 (EMBL:AL583922) (924 aa) fasta scores: E(): 1.1e-107, 47.24% id in 853 aa; RNA-associated protein complement(1824673..1827561) Corynebacterium diphtheriae NCTC 13129 2649407 NP_940121.1 CDS ndk NC_002935.2 1827843 1828277 R catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase complement(1827843..1828277) Corynebacterium diphtheriae NCTC 13129 2649408 NP_940122.1 CDS DIP1784 NC_002935.2 1828445 1828858 R Similar to Mycobacterium tuberculosis hypothetical protein Rv2446c TR:O53173 (EMBL:AL021246) (123 aa) fasta scores: E(): 1.5e-07, 31.35% id in 118 aa, and to Mycobacterium leprae conserved membrane protein ML1470 TR:Q9CBY9 (EMBL:AL583922) (123 aa) fasta scores: E(): 4.9e-07, 30.46% id in 128 aa; hypothetical protein complement(1828445..1828858) Corynebacterium diphtheriae NCTC 13129 2649409 NP_940123.1 CDS DIP1785 NC_002935.2 1828855 1830351 R Similar to Mycobacterium tuberculosis folylpolyglutamate synthase Rv2447c TR:O53174 (EMBL:AL021246) (487 aa) fasta scores: E(): 1.2e-100, 57.46% id in 496 aa, and to Mycobacterium leprae folylpolyglutamate synthase ML1471 TR:Q9CBY8 (EMBL:AL583922) (485 aa) fasta scores: E(): 3.8e-96, 56.17% id in 470 aa; Mur ligase complement(1828855..1830351) Corynebacterium diphtheriae NCTC 13129 2649410 NP_940124.1 CDS valS NC_002935.2 1830348 1833107 R valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase complement(1830348..1833107) Corynebacterium diphtheriae NCTC 13129 2649411 NP_940125.1 CDS mdh NC_002935.2 1833151 1834131 R catalyzes the oxidation of malate to oxaloacetate; malate dehydrogenase complement(1833151..1834131) Corynebacterium diphtheriae NCTC 13129 2649412 NP_940126.1 CDS DIP1788 NC_002935.2 1834614 1835366 D Similar to Rhizobium meliloti transcription regulator protein SMC04134 TR:CAC41505 (EMBL:AL591782) (225 aa) fasta scores: E(): 3.4e-17, 30.8% id in 198 aa, and to Caulobacter crescentus TetR family transcriptional regulator CC2608 TR:Q9A556 (EMBL:AE005928) (230 aa) fasta scores: E(): 4e-13, 31.7% id in 205 aa; TetR family regulatory protein 1834614..1835366 Corynebacterium diphtheriae NCTC 13129 2649413 NP_940127.1 CDS clpX NC_002935.2 1835403 1836695 R binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX complement(1835403..1836695) Corynebacterium diphtheriae NCTC 13129 2649414 NP_940128.1 CDS DIP1790 NC_002935.2 1836842 1839373 R N-terminal region is similar to Streptomyces griseus para-aminobenzoate synthase Pab SW:PABS_STRGR (P32483) (723 aa) fasta scores: E(): 1.8e-48, 39.11% id in 698 aa, and to Streptomyces pristinaespiralis p-aminobenzoate synthase PapA TR:P72539 (EMBL:U60417) (719 aa) fasta scores: E(): 6.1e-43, 35.83% id in 734 aa; glutamine amidotransferase complement(1836842..1839373) Corynebacterium diphtheriae NCTC 13129 2649415 NP_940129.1 CDS clpP2 NC_002935.2 1839462 1840091 R hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit complement(1839462..1840091) Corynebacterium diphtheriae NCTC 13129 2649416 NP_940130.1 CDS clpP NC_002935.2 1840109 1840708 R hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit complement(1840109..1840708) Corynebacterium diphtheriae NCTC 13129 2649417 NP_940131.1 CDS tig NC_002935.2 1840874 1842220 R Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor complement(1840874..1842220) Corynebacterium diphtheriae NCTC 13129 2649418 NP_940132.1 CDS DIP1794 NC_002935.2 1843047 1843283 D Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 1843047..1843283 Corynebacterium diphtheriae NCTC 13129 2649421 NP_940133.1 CDS DIP1795 NC_002935.2 1843430 1844212 D Poor database matches. Similar to the C-terminal region of Streptomyces coelicolor secreted protein SC1C2.11 TR:O86512 (EMBL:AL031124) (450 aa) fasta scores: E(): 0.47, 27.13% id in 269 aa; hypothetical protein 1843430..1844212 Corynebacterium diphtheriae NCTC 13129 2649422 NP_940134.1 CDS DIP1796 NC_002935.2 1844289 1844762 R catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity; ribose-5-phosphate isomerase B complement(1844289..1844762) Corynebacterium diphtheriae NCTC 13129 2649423 NP_940135.1 CDS DIP1797 NC_002935.2 1844794 1845414 R Similar to Mycobacterium tuberculosis hypothetical protein Rv2466c TR:O53193 (EMBL:AL021246) (207 aa) fasta scores: E(): 2.5e-43, 57.63% id in 203 aa, and to Mycobacterium leprae hypothetical protein ML1485 TR:Q9CBY0 (EMBL:AL583922) (207 aa) fasta scores: E(): 1.7e-40, 55.94% id in 202 aa; hypothetical protein complement(1844794..1845414) Corynebacterium diphtheriae NCTC 13129 2649424 NP_940136.1 CDS DIP1798 NC_002935.2 1845536 1848154 D Similar to Streptomyces lividans aminopeptidase N PepN SW:AMPN_STRLI (Q11010) (857 aa) fasta scores: E(): 1.2e-88, 45.27% id in 888 aa, and to Mycobacterium tuberculosis aminopeptidase Rv2467 TR:O53194 (EMBL:AL021246) (861 aa) fasta scores: E(): 1.9e-132, 51.97% id in 885 aa. CDS appears to be extended at the N-terminus in comparison to orthologues. Possible alternative translational start site, although current start has better RBS and extented region contains Pfam hit; aminopeptidase 1845536..1848154 Corynebacterium diphtheriae NCTC 13129 2649425 NP_940137.1 CDS DIP1799 NC_002935.2 1848410 1849426 D C-terminus is similar to thye C-terminal region of Streptomyces coelicolor hypothetical protein SCF43A.26C TR:Q9XA89 (EMBL:AL096837) (333 aa) fasta scores: E(): 1.4e-38, 41.75% id in 297 aa. Similar to an internal region of Streptomyces coelicolor membrane protein SC8E4A.26 TR:Q9L1X9 (EMBL:AL138662) (408 aa) fasta scores: E(): 2.7e-28, 38.41% id in 302 aa; mechanosensitive ion channel protein MscS 1848410..1849426 Corynebacterium diphtheriae NCTC 13129 2649426 NP_940138.1 CDS DIP1800 NC_002935.2 1849438 1849830 D Similar to Mycobacterium tuberculosis hemoglobin-like protein Rv2470 TR:O53197 (EMBL:AL021246) (128 aa) fasta scores: E(): 6.5e-24, 51.61% id in 124 aa, and to Mycobacterium leprae hemoglobin-like protein ML1253 TR:Q9CC59 (EMBL:AL583921) (128 aa) fasta scores: E(): 5.9e-23, 50.8% id in 124 aa; hemoglobin 1849438..1849830 Corynebacterium diphtheriae NCTC 13129 2649427 NP_940139.1 CDS DIP1801 NC_002935.2 1849827 1850447 R Limited database matches. Similar to Mycobacterium tuberculosis hypothetical protein Rv2474c TR:O53201 (EMBL:AL021246) (217 aa) fasta scores: E(): 2.2e-14, 39.59% id in 197 aa; hypothetical protein complement(1849827..1850447) Corynebacterium diphtheriae NCTC 13129 2649428 NP_940140.1 CDS DIP1802 NC_002935.2 1850457 1850900 R Similar to Halobacterium sp hypothetical protein VNG1407C TR:Q9HPZ1 (EMBL:AE005058) (132 aa) fasta scores: E(): 2.8e-09, 37.06% id in 116 aa, and to Pseudomonas aeruginosa hypothetical protein PA2801 TR:Q9I042 (EMBL:AE004707) (134 aa) fasta scores: E(): 4e-07, 35.38% id in 130 aa; hypothetical protein complement(1850457..1850900) Corynebacterium diphtheriae NCTC 13129 2649429 NP_940141.1 CDS DIP1803 NC_002935.2 1851027 1852697 R ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; ABC transporter ATP-binding protein complement(1851027..1852697) Corynebacterium diphtheriae NCTC 13129 2649430 NP_940142.1 CDS DIP1804 NC_002935.2 1852795 1853283 R Similar to Mycobacterium tuberculosis single-strand binding protein Ssb SW:SSB_MYCTU (P71711) (164 aa) fasta scores: E(): 0.00073, 29.11% id in 158 aa, and to Mycobacterium smegmatis single-stranded DNA-binding protein TR:Q9AFI5 (EMBL:AF349434) (165 aa) fasta scores: E(): 0.00024, 27.95% id in 161 aa; single-strand binding protein complement(1852795..1853283) Corynebacterium diphtheriae NCTC 13129 2649431 NP_940143.1 CDS DIP1805 NC_002935.2 1853467 1855503 R Similar to Mycobacterium leprae hypothetical protein ML1998 SW:Y102_MYCLE (P53525) (659 aa) fasta scores: E(): 2e-44, 31.72% id in 665 aa, and to Mycobacterium tuberculosis hypothetical protein Rv0102 SW:Y102_MYCTU (Q10897) (661 aa) fasta scores: E(): 2.2e-44, 30.76% id in 650 aa; hypothetical protein complement(1853467..1855503) Corynebacterium diphtheriae NCTC 13129 2649432 NP_940144.1 CDS cstA1 NC_002935.2 1855730 1858015 D Similar to Escherichia coli carbon starvation protein A CstA SW:CSTA_ECOLI (P15078) (701 aa) fasta scores: E(): 2.3e-129, 53.01% id in 696 aa, and to Mycobacterium tuberculosis carbon starvation protein A homologue Rv3063 SW:CSTA_MYCTU (P95095) (758 aa) fasta scores: E(): 5.9e-175, 61.47% id in 719 aa. CDS contains an extended N-terminus in comparison to the E. coli orthologue; carbon starvation protein 1855730..1858015 Corynebacterium diphtheriae NCTC 13129 2649433 NP_940145.1 CDS DIP1807 NC_002935.2 1858036 1858236 D Similar to Pseudomonas aeruginosa hypothetical protein PA4605 TR:Q9HVI4 (EMBL:AE004874) (67 aa) fasta scores: E(): 0.032, 29.57% id in 71 aa, and to Campylobacter jejuni hypothetical protein Cj0916c TR:Q9PP17 (EMBL:AL139076) (65 aa) fasta scores: E(): 0.052, 34.61% id in 52 aa; hypothetical protein 1858036..1858236 Corynebacterium diphtheriae NCTC 13129 2649434 NP_940146.1 CDS DIP1808 NC_002935.2 1858313 1858795 D Similar to Streptococcus pneumoniae hypothetical 20.7 kDa protein TR:Q9KK22 (EMBL:AF154034) (171 aa) fasta scores: E(): 1.3e-08, 33.75% id in 157 aa and to Yersinia pestis insertion element IS1661 DNA-binding protein YPO3492 TR:CAC92721 (EMBL:AJ414157) (171 aa) fasta scores: E(): 0.00044, 25.45% id in 165 aa. Identical to DIP0435, DIP1518, DIP1525 and DIP2124; insertion element DNA-binding protein 1858313..1858795 Corynebacterium diphtheriae NCTC 13129 2649435 NP_940147.1 CDS DIP1809 NC_002935.2 1858843 1859655 D Similar to Escherichia coli transposase InsK for insertion sequence element IS150 or B3558 SW:INSK_ECOLI (P19769) (283 aa) fasta scores: E(): 2.5e-43, 44.86% id in 263 aa. Identical to DIP0434, DIP1517, DIP1526 and DIP2123; transposase 1858843..1859655 Corynebacterium diphtheriae NCTC 13129 2649436 NP_940148.1 CDS DIP1810 NC_002935.2 1859708 1860913 R Similar to Streptomyces spectabilis export protein SpcT TR:Q9L629 (EMBL:AF244574) (432 aa) fasta scores: E(): 3.1e-05, 28.46% id in 411 aa, and to Mycobacterium tuberculosis membrane protein Rv0246 TR:O53668 (EMBL:AL021929) (436 aa) fasta scores: E(): 5.4e-06, 20.94% id in 401 aa; hypothetical protein complement(1859708..1860913) Corynebacterium diphtheriae NCTC 13129 2649437 NP_940149.1 CDS DIP1811 NC_002935.2 1861303 1862349 D Similar to Rhizobium loti dehydrogenase; zinc-binding alcohol dehydrogenase; NADPH quinone oxidoreductase; oxidoreductase MLR3212 TR:Q98GR0 (EMBL:AP003001) (329 aa) fasta scores: E(): 4.7e-52, 47.67% id in 323 aa, and to Pseudomonas aeruginosa probable oxidoreductase PA1833 TR:Q9I2R2 (EMBL:AE004609) (330 aa) fasta scores: E(): 5.9e-45, 43.82% id in 324 aa; zinc-binding dehydrogenase 1861303..1862349 Corynebacterium diphtheriae NCTC 13129 2649439 NP_940150.1 CDS DIP1812 NC_002935.2 1862409 1863209 D Similar to Mycobacterium tuberculosis hypothetical protein Rv2509 TR:O06172 (EMBL:Z95556) (268 aa) fasta scores: E(): 1.3e-46, 52.25% id in 266 aa, and to Mycobacterium leprae dehydrogenase MLCl383.36c TR:O07709 (EMBL:Z97179) (268 aa) fasta scores: E(): 1.8e-44, 50.56% id in 265 aa; short chain dehydrogenase 1862409..1863209 Corynebacterium diphtheriae NCTC 13129 2649440 NP_940151.1 CDS orn NC_002935.2 1863228 1863860 D 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 1863228..1863860 Corynebacterium diphtheriae NCTC 13129 2649441 NP_940152.1 CDS DIP1814 NC_002935.2 1864038 1864868 D Similar to Corynebacterium glutamicum dihydrodipicolinate synthase DapA SW:DAPA_CORGL (P19808) (301 aa) fasta scores: E(): 7.7e-14, 29.25% id in 270 aa, and to Streptomyces coelicolor dihydrodipicolinate synthase SC9A10.08 SW:DAPA_STRCO (O86841) (299 aa) fasta scores: E(): 2.5e-13, 27.94% id in 272 aa; dihydrodipicolinate synthase 1864038..1864868 Corynebacterium diphtheriae NCTC 13129 2649443 NP_940153.1 CDS DIP1815 NC_002935.2 1864869 1866038 R Similar to Mycobacterium tuberculosis hypothetical protein Rv2518c TR:O53223 (EMBL:AL021185) (408 aa) fasta scores: E(): 6.9e-67, 53.02% id in 347 aa, and to Mycobacterium leprae secreted protein ML0426 TR:Q9CCU5 (EMBL:AL583918) (404 aa) fasta scores: E(): 5.2e-63, 49.28% id in 349 aa; lipoprotein complement(1864869..1866038) Corynebacterium diphtheriae NCTC 13129 2649444 NP_940154.1 CDS DIP1816 NC_002935.2 1866129 1866317 R hypothetical protein complement(1866129..1866317) Corynebacterium diphtheriae NCTC 13129 2649445 NP_940155.1 CDS DIP1817 NC_002935.2 1866723 1866953 D Weakly similar to Bacillus halodurans hypothetical protein Bh3463 TR:Q9K7A5 (EMBL:AP001518) (79 aa) fasta scores: E(): 2.9, 27.778% id in 72 aa; hypothetical protein 1866723..1866953 Corynebacterium diphtheriae NCTC 13129 2649447 NP_940156.1 CDS DIP1818 NC_002935.2 1866950 1867234 D hypothetical protein 1866950..1867234 Corynebacterium diphtheriae NCTC 13129 2649448 NP_940157.1 CDS DIP1819 NC_002935.2 1867227 1867556 D hypothetical protein 1867227..1867556 Corynebacterium diphtheriae NCTC 13129 2649449 NP_940158.1 CDS DIP1820 NC_002935.2 1867754 1867873 D hypothetical protein 1867754..1867873 Corynebacterium diphtheriae NCTC 13129 2649450 NP_940159.1 CDS DIP1821 NC_002935.2 1867939 1868061 D Questionable CDS; no significant database matches; hypothetical protein 1867939..1868061 Corynebacterium diphtheriae NCTC 13129 2649451 NP_940160.1 CDS DIP1822 NC_002935.2 1868441 1868842 D hypothetical protein 1868441..1868842 Corynebacterium diphtheriae NCTC 13129 2649452 NP_940161.1 CDS DIP1823 NC_002935.2 1868835 1869113 D Similar to bacteriophage phi-C31 hypothetical protein orf 7 TR:Q38028 (EMBL:X76288) (121 aa) fasta scores: E(): 0.0011, 40.385% id in 52 aa, and to Deinococcus radiodurans conserved hypothetical protein DR2409 TR:Q9RRS6 (EMBL:AE002071) (186 aa) fasta scores: E(): 0.0026, 39.683% id in 63 aa, and to Mycobacterium tuberculosis CDC1551 HNH endonuclease MT2545 TR:AAK46845 (EMBL:AE007091) (222 aa) fasta scores: E(): 0.049, 36.986% id in 73 aa; HNH endonuclease 1868835..1869113 Corynebacterium diphtheriae NCTC 13129 2649453 NP_940162.1 CDS DIP1824 NC_002935.2 1869496 1870953 D Similar to Mycobacteriophage TM4 terminase gp4 TR:Q9ZX73 (EMBL:AF068845) (474 aa) fasta scores: E(): 2.6e-13, 24.364% id in 472 aa, and to Bacteriophage HK97 terminase large subunit 2 TR:Q9MCT1 (EMBL:AF069529) (504 aa) fasta scores: E(): 0.019, 23.741% id in 278 aa; phage terminase 1869496..1870953 Corynebacterium diphtheriae NCTC 13129 2649454 NP_940163.1 CDS DIP1825 NC_002935.2 1871192 1872241 D hypothetical protein 1871192..1872241 Corynebacterium diphtheriae NCTC 13129 2649455 NP_940164.1 CDS DIP1826 NC_002935.2 1872225 1872776 D Some similarity to Clostridium perfringens plasmid pCP13 hypothetical 28.2 kDa protein pcp29 TR:BAB62467 (EMBL:AP003515) (252 aa) fasta scores: E(): 1.4e-05, 27.513% id in 189 aa; hypothetical protein 1872225..1872776 Corynebacterium diphtheriae NCTC 13129 2649456 NP_940165.1 CDS DIP1827 NC_002935.2 1872831 1873118 R hypothetical protein complement(1872831..1873118) Corynebacterium diphtheriae NCTC 13129 2649457 NP_940166.1 CDS DIP1828 NC_002935.2 1873196 1874599 D Similar to Mycobacterium tuberculosis hypothetical 18.5 kDa protein Rv1577c or MTCY336.27 TR:O06613 (EMBL:Z95586) (170 aa) fasta scores: E(): 4.4e-06, 34.507% id in 142 aa, and to Mycobacterium tuberculosis hypothetical 19.3 kDa protein Rv2651c or MTCY441.20c TR:P71948 (EMBL:Z80225) (177 aa) fasta scores: E(): 4.5e-06, 35.664% id in 143 aa; hypothetical protein 1873196..1874599 Corynebacterium diphtheriae NCTC 13129 2649458 NP_940167.1 CDS DIP1829 NC_002935.2 1874599 1874910 D hypothetical protein 1874599..1874910 Corynebacterium diphtheriae NCTC 13129 2649459 NP_940168.1 CDS DIP1830 NC_002935.2 1874955 1875281 D hypothetical protein 1874955..1875281 Corynebacterium diphtheriae NCTC 13129 2649205 NP_940169.1 CDS DIP1831 NC_002935.2 1875281 1875703 D Similar to Bifidobacterium longum NCC2705 hypothetical protein BL0379 SWALL:AAN24215 (EMBL:AE014655) (140 aa) fasta scores: E(): 1.7e-05, 34.14% id in 123 aa; hypothetical protein 1875281..1875703 Corynebacterium diphtheriae NCTC 13129 2649206 NP_940170.1 CDS DIP1832 NC_002935.2 1875706 1876119 D Similar to Bacteriophage phi-C31 gp40 40 TR:Q9ZXA7 (EMBL:AJ006589) (143 aa) fasta scores: E(): 1.3e-05, 25.362% id in 138 aa; hypothetical protein 1875706..1876119 Corynebacterium diphtheriae NCTC 13129 2649207 NP_940171.1 CDS DIP1833 NC_002935.2 1876119 1876430 D Similar to Bacteriophage Mu hypothetical protein gp14 14 or e15 SW:VG14_BPMU (Q38492) (100 aa) fasta scores: E(): 0.86, 32.955% id in 88 aa; hypothetical protein 1876119..1876430 Corynebacterium diphtheriae NCTC 13129 2649208 NP_940172.1 CDS DIP1834 NC_002935.2 1876508 1878073 D Similar to Bacteriophage r1t ORF40 TR:Q38126 (EMBL:U38906) (213 aa) fasta scores: E(): 0.019, 25.904% id in 166 aa, and to Escherichia coli O157:H7 tail length tape measure protein precursor ECS2949 TR:BAB36372 (EMBL:AP002560) (881 aa) fasta scores: E(): 0.025, 27.698% id in 278 aa; hypothetical protein 1876508..1878073 Corynebacterium diphtheriae NCTC 13129 2649209 NP_940173.1 CDS DIP1835 NC_002935.2 1878067 1879254 D hypothetical protein 1878067..1879254 Corynebacterium diphtheriae NCTC 13129 2649210 NP_940174.1 CDS DIP1836 NC_002935.2 1879255 1880043 D Contains collagen-like Pro/Gly repeat; Similar to Gallus gallus collagen alpha 1 Col3A1 SW:CA13_CHICK (P12105) (1262 aa) fasta scores: E(): 3.8e-13, 48.023% id in 177 aa; triple helix repeat-containing collagen 1879255..1880043 Corynebacterium diphtheriae NCTC 13129 2649211 NP_940175.1 CDS DIP1837 NC_002935.2 1880040 1880855 R Similar to Mycobacterium tuberculosis CDC1551 phage integrase MT2724 TR:AAK47038 (EMBL:AE007103) (332 aa) fasta scores: E(): 1.9e-29, 39.615% id in 260 aa, and to Bacillus subtilis probable integrase/recombinase RipX ripX SW:RIPX_BACSU (P46352) (296 aa) fasta scores: E(): 0.00033, 30.435% id in 230 aa; phage integrase complement(1880040..1880855) Corynebacterium diphtheriae NCTC 13129 2649212 NP_940176.1 CDS DIP1838 NC_002935.2 1881329 1881508 R hypothetical protein complement(1881329..1881508) Corynebacterium diphtheriae NCTC 13129 2649213 NP_940177.1 CDS DIP1840 NC_002935.2 1881693 1882151 D Poor database matches. C-terminus is similar to the C-terminal regions of Streptomyces coelicolor nicotinamidase SCE19A.18 TR:Q9S2G3 (EMBL:AL096852) (195 aa) fasta scores: E(): 6.4e-06, 33.33% id in 105 aa, and Mycobacterium avium pyrazinamidase/nicotinamidase PncA TR:P94914 (EMBL:U80820) (187 aa) fasta scores: E(): 2.8e-05, 36% id in 125 aa; hypothetical protein 1881693..1882151 Corynebacterium diphtheriae NCTC 13129 2649214 NP_940178.1 CDS DIP1841 NC_002935.2 1882155 1882460 R Similar to Mycobacterium tuberculosis hypothetical protein Rv3592 TR:O06156 (EMBL:Z95555) (105 aa) fasta scores: E(): 1.5e-21, 58.16% id in 98 aa, and to Mycobacterium leprae hypothetical protein ML1922 TR:Q9CBI8 (EMBL:AL583923) (105 aa) fasta scores: E(): 5.5e-19, 53.46% id in 101 aa; hypothetical protein complement(1882155..1882460) Corynebacterium diphtheriae NCTC 13129 2649215 NP_940179.1 CDS DIP1842 NC_002935.2 1882473 1882748 R Poor database matches. Similar to Mycobacterium tuberculosis hypothetical protein Rv2520c TR:O53225 (EMBL:AL021185) (75 aa) fasta scores: E(): 2.7e-06, 45.33% id in 75 aa; hypothetical protein complement(1882473..1882748) Corynebacterium diphtheriae NCTC 13129 2649216 NP_940180.1 CDS bcp NC_002935.2 1882837 1883310 D Similar to Escherichia coli bacterioferritin comigratory protein Bcp SW:BCP_ECOLI (P23480) (156 aa) fasta scores: E(): 7e-23, 46.8% id in 141 aa, and to Mycobacterium tuberculosis bacterioferritin comigratory protein Rv2521 TR:O53226 (EMBL:AL021185) (157 aa) fasta scores: E(): 3.5e-37, 62.17% id in 156 aa; bacterioferritin comigratory protein 1882837..1883310 Corynebacterium diphtheriae NCTC 13129 2649217 NP_940181.1 CDS DIP1844 NC_002935.2 1883311 1883955 D Similar to Rhizobium loti transcriptional regulator MLL3939 TR:Q98F48 (EMBL:AP003003) (209 aa) fasta scores: E(): 4.6e-12, 33.65% id in 208 aa, and to Pseudomonas aeruginosa probable transcriptional regulator PA1403 TR:Q9I3U1 (EMBL:AE004569) (210 aa) fasta scores: E(): 2e-05, 27.57% id in 214 aa; TetR family regulatory protein 1883311..1883955 Corynebacterium diphtheriae NCTC 13129 2649218 NP_940182.1 CDS acpS NC_002935.2 1883952 1884335 R Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase complement(1883952..1884335) Corynebacterium diphtheriae NCTC 13129 2649219 NP_940183.1 CDS fas NC_002935.2 1884370 1893303 R Similar to the N-terminal region of Corynebacterium ammoniagenes fatty acid synthase Fas TR:Q04846 (EMBL:X64795) (3104 aa) fasta scores: E(): 0, 61.33% id in 3018 aa, and to the full length of Mycobacterium tuberculosis fatty acid synthase Rv2524c TR:AAK46907 (EMBL:Z83863) (3069 aa) fasta scores: E(): 1e-197, 51.37% id in 3083 aa, and of Corynebacterium glutamicum 3-oxoacyl-(acyl-carrier-protein) synthase CGL2495 SWALL:Q8NMS0 (EMBL:AP005281) (2993 aa) fasta scores: E(): 0, 67.35% id in 3008 aa; fatty acid synthase complement(1884370..1893303) Corynebacterium diphtheriae NCTC 13129 2649220 NP_940184.1 CDS DIP1847 NC_002935.2 1893482 1893859 R hypothetical protein complement(1893482..1893859) Corynebacterium diphtheriae NCTC 13129 2649221 NP_940185.1 CDS DIP1848 NC_002935.2 1894158 1894535 D Similar to Mycobacterium tuberculosis hypothetical protein Rv1343c SW:YD43_MYCTU (Q11013) (126 aa) fasta scores: E(): 6.9e-12, 47.61% id in 84 aa, and to Mycobacterium leprae hypothetical protein ML1177 SW:YD43_MYCLE (P54134) (126 aa) fasta scores: E(): 1.5e-11, 46.42% id in 84 aa; hypothetical protein 1894158..1894535 Corynebacterium diphtheriae NCTC 13129 2649223 NP_940186.1 CDS DIP1849 NC_002935.2 1894563 1894919 D Similar to Mycobacterium leprae hypothetical protein ML1176 (P54133) (119 aa) fasta scores: E(): 3.7e-09, 39.28% id in 112 aa, and to Mycobacterium tuberculosis hypothetical protein Rv1342c SW:YD42_MYCTU (Q11012) (120 aa) fasta scores: E(): 1.5e-08, 37.16% id in 113 aa; hypothetical protein 1894563..1894919 Corynebacterium diphtheriae NCTC 13129 2649224 NP_940187.1 CDS DIP1850 NC_002935.2 1894916 1895539 R HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase complement(1894916..1895539) Corynebacterium diphtheriae NCTC 13129 2649225 NP_940188.1 CDS rph NC_002935.2 1895536 1896261 R RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH complement(1895536..1896261) Corynebacterium diphtheriae NCTC 13129 2649226 NP_940189.1 CDS DIP1852 NC_002935.2 1896272 1897090 R Similar to Mycobacterium tuberculosis hypothetical protein Rv1339 SW:YD39_MYCTU (Q10648) (273 aa) fasta scores: E(): 5.5e-46, 46.18% id in 249 aa, and to Mycobacterium leprae hypothetical protein ML1173 SW:YD39_MYCLE (P50474) (284 aa) fasta scores: E(): 6.6e-46, 46.18% id in 249 aa; hypothetical protein complement(1896272..1897090) Corynebacterium diphtheriae NCTC 13129 2649227 NP_940190.1 CDS murI NC_002935.2 1897092 1897889 R converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase complement(1897092..1897889) Corynebacterium diphtheriae NCTC 13129 2649228 NP_940191.1 CDS DIP1854 NC_002935.2 1897886 1898458 R Similar to Synechocystis sp. hypothetical protein SLR1461 TR:P74553 (EMBL:D90916) (198 aa) fasta scores: E(): 3e-21, 38.95% id in 172 aa, and to Bacillus halodurans hypothetical protein BH0517 TR:Q9KFG2 (EMBL:AP001508) (248 aa) fasta scores: E(): 3.1e-05, 29.1% id in 189 aa; hypothetical protein complement(1897886..1898458) Corynebacterium diphtheriae NCTC 13129 2649229 NP_940192.1 CDS DIP1855 NC_002935.2 1898455 1899387 R Similar to Mycobacterium leprae hypothetical protein ML1167 SW:YD33_MYCLE (P53425) (362 aa) fasta scores: E(): 4.2e-24, 48.07% id in 337 aa, and to Streptomyces coelicolor hypothetical protein SCE22.10 TR:Q9KYV2 (EMBL:AL355832) (348 aa) fasta scores: E(): 4.6e-24, 47.38% id in 325 aa; hypothetical protein complement(1898455..1899387) Corynebacterium diphtheriae NCTC 13129 2649230 NP_940193.1 CDS DIP1856 NC_002935.2 1899387 1899923 R Similar to Mycobacterium tuberculosis hypothetical protein Rv1332 SW:YD32_MYCTU (Q10643) (218 aa) fasta scores: E(): 1.3e-10, 35.53% id in 197 aa, and to Mycobacterium leprae hypothetical protein ML1166 SW:YD32_MYCLE (P53424) (217 aa) fasta scores: E(): 2.1e-08, 33.5% id in 200 aa. CDS is contains fewer residues at the N-terminus in comparison to the Mycobacterium proteins; hypothetical protein complement(1899387..1899923) Corynebacterium diphtheriae NCTC 13129 2649231 NP_940194.1 CDS clpS NC_002935.2 1899940 1900281 R involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS complement(1899940..1900281) Corynebacterium diphtheriae NCTC 13129 2649232 NP_940195.1 CDS DIP1858 NC_002935.2 1900343 1901656 D catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 1900343..1901656 Corynebacterium diphtheriae NCTC 13129 2649233 NP_940196.1 CDS DIP1859 NC_002935.2 1901706 1903655 D Similar to Escherichia coli probable ATP-dependent helicase DinG SW:DING_ECOLI (P27296) (716 aa) fasta scores: E(): 5.6e-15, 27.57% id in 689 aa, and to Mycobacterium tuberculosis probable ATP-dependent helicase DinG homologue Rv1329c SW:DING_MYCTU (Q10640) (664 aa) fasta scores: E(): 2.2e-131, 55.84% id in 659 aa; DeaD/DeaH family helicase 1901706..1903655 Corynebacterium diphtheriae NCTC 13129 2649234 NP_940197.1 CDS DIP1860 NC_002935.2 1903657 1904184 D Similar to Streptomyces coelicolor acetyltransferase SCC46.14 TR:Q9L1I8 (EMBL:AL139164) (202 aa) fasta scores: E(): 1.3e-08, 28.09% id in 178 aa, and to Deinococcus radiodurans acetyltransferase DR1800 TR:Q9RTG4 (EMBL:AE002021) (179 aa) fasta scores: E(): 8.9e-08, 29.76% id in 168 aa; acetyltransferase (GNAT) family protein 1903657..1904184 Corynebacterium diphtheriae NCTC 13129 2649235 NP_940198.1 CDS DIP1861 NC_002935.2 1904274 1905374 D No significant database matches to the full length CDS. C-terminus is similar to an internal region of Mycobacterium tuberculosis hypothetical protein Rv2100 SW:YL00_MYCTU (Q10709) (550 aa) fasta scores: E(): 9.8e-09, 35.15% id in 128 aa; hypothetical protein 1904274..1905374 Corynebacterium diphtheriae NCTC 13129 2649236 NP_940199.1 CDS DIP1862 NC_002935.2 1905358 1906065 R Poor database matches. Similar to Streptomyces coelicolor hypothetical protein SC1B5.06c TR:O69834 (EMBL:AL023517) (249 aa) fasta scores: E(): 9e-23, 41.42% id in 210 aa. C-terminal region is similar to Pyrococcus horikoshii hypothetical protein PH1539 SW:YF39_PYRHO (O74017) (121 aa) fasta scores: E(): 0.0025, 36.84% id in 95 aa; hypothetical protein complement(1905358..1906065) Corynebacterium diphtheriae NCTC 13129 2649237 NP_940200.1 CDS DIP1863 NC_002935.2 1906058 1907290 R Similar to Mycobacterium tuberculosis hypothetical protein Rv3042c TR:AAK47457 (EMBL:AL021287) (409 aa) fasta scores: E(): 3.1e-69, 54.54% id in 407 aa, and to Mycobacterium leprae phosphoserine phosphatase ML1727 TR:Q9CBQ6 (EMBL:AL583923) (411 aa) fasta scores: E(): 6.2e-66, 53.82% id in 405 aa; hydrolase complement(1906058..1907290) Corynebacterium diphtheriae NCTC 13129 2649238 NP_940201.1 CDS ctaD NC_002935.2 1907448 1909142 R Similar to Bacillus firmus cytochrome C oxidase subunit I CtaD SW:COX1_BACFI (Q04440) (624 aa) fasta scores: E(): 9.5e-98, 48.56% id in 523 aa, and to Corynebacterium glutamicum cytochrome AA3 oxidase subunit I CtaD TR:Q9AEL9 (EMBL:AJ306417) (584 aa) fasta scores: E(): 1.2e-200, 84.39% id in 564 aa; cytochrome C oxidase polypeptide I complement(1907448..1909142) Corynebacterium diphtheriae NCTC 13129 2649239 NP_940202.1 CDS nrdF NC_002935.2 1909504 1910490 R B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta complement(1909504..1910490) Corynebacterium diphtheriae NCTC 13129 2649240 NP_940203.1 CDS DIP1866 NC_002935.2 1910803 1911288 D Similar to Escherichia coli ferritin 1 FtnA SW:FTNA_ECOLI (P23887) (165 aa) fasta scores: E(): 5.9e-10, 29.29% id in 157 aa, and to Methanothermobacter thermautotrophicus ferritin like protein MTH158 TR:O26261 (EMBL:AE000804) (171 aa) fasta scores: E(): 2.6e-17, 36.25% id in 160 aa; bacterioferritin 1910803..1911288 Corynebacterium diphtheriae NCTC 13129 2649241 NP_940204.1 CDS nrdE NC_002935.2 1911340 1913499 R Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha complement(1911340..1913499) Corynebacterium diphtheriae NCTC 13129 2649242 NP_940205.1 CDS nrdI NC_002935.2 1913549 1913974 R in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein complement(1913549..1913974) Corynebacterium diphtheriae NCTC 13129 2649243 NP_940206.1 CDS DIP1869 NC_002935.2 1914068 1914301 R Similar to Escherichia coli glutaredoxin-like protein NrdH SW:NRDH_ECOLI (Q47414) (81 aa) fasta scores: E(): 4.5e-09, 41.66% id in 72 aa, and to Corynebacterium ammoniagenes NrdH-redoxin TR:O69271 (EMBL:Y09572) (75 aa) fasta scores: E(): 4.4e-23, 81.08% id in 74 aa; hypothetical protein complement(1914068..1914301) Corynebacterium diphtheriae NCTC 13129 2649244 NP_940207.1 CDS DIP1870 NC_002935.2 1914603 1915475 D Similar to Agrobacterium aurantiacum phytoene synthase CrtB SW:CRTB_AGRAU (P54975) (301 aa) fasta scores: E(): 6.8e-09, 29.57% id in 284 aa, and to Corynebacterium glutamicum phytoene synthase CrtB TR:AAK64298 (EMBL:AF159510) (304 aa) fasta scores: E(): 1.1e-51, 51.22% id in 285 aa; phytoene synthase 1914603..1915475 Corynebacterium diphtheriae NCTC 13129 2649245 NP_940208.1 CDS DIP1871 NC_002935.2 1915468 1916994 D Similar to Neurospora crassa phytoene dehydrogenase Al-1 SW:CRTI_NEUCR (P21334) (595 aa) fasta scores: E(): 1.6e-33, 29.77% id in 524 aa, and to Corynebacterium glutamicum phytoene desaturase CrtI TR:AAK64299 (EMBL:AF159510) (549 aa) fasta scores: E(): 5.6e-107, 54.59% id in 511 aa; phytoene dehydrogenase related enzyme 1915468..1916994 Corynebacterium diphtheriae NCTC 13129 2649246 NP_940209.1 CDS rpmJ NC_002935.2 1917063 1917185 R smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif; 50S ribosomal protein L36 complement(1917063..1917185) Corynebacterium diphtheriae NCTC 13129 2649247 NP_940210.1 CDS nadE NC_002935.2 1917354 1918172 D catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 1917354..1918172 Corynebacterium diphtheriae NCTC 13129 2649248 NP_940211.1 CDS DIP1874 NC_002935.2 1918169 1918606 R Similar to Streptomyces coelicolor hypothetical protein SCJ12.09c TR:Q9RI49 (EMBL:AL109989) (146 aa) fasta scores: E(): 7.2e-10, 38.68% id in 137 aa. C-terminal region is similar to Mycobacterium tuberculosis hypothetical protein Rv3129 TR:O05803 (EMBL:Z95150) (110 aa) fasta scores: E(): 5.1e-11, 47.77% id in 90 aa; hypothetical protein complement(1918169..1918606) Corynebacterium diphtheriae NCTC 13129 2649249 NP_940212.1 CDS DIP1875 NC_002935.2 1918653 1918961 R Poor database matches. C-terminal region is similar to Clostridium acetobutylicum hypothetical protein CAC0072 TR:AAK78058 (EMBL:AE007520) (77 aa) fasta scores: E(): 0.01, 29.16% id in 72 aa; hypothetical protein complement(1918653..1918961) Corynebacterium diphtheriae NCTC 13129 2649250 NP_940213.1 CDS DIP1876 NC_002935.2 1918965 1920353 R C-terminus is similar to an internal regions of Neisseria gonorrhoeae major anaerobically induced outer membrane protein Pan 1 AniA SW:ANIA_NEIGO (Q02219) (392 aa) fasta scores: E(): 3.5e-18, 30.1% id in 299 aa, and Neisseria meningitidis nitrite reductase, major outer membrane copper-containing protein NMA1887 TR:Q9JTB8 (EMBL:AL162757) (386 aa) fasta scores: E(): 3e-18, 30.43% id in 299 aa; multicopper oxidase complement(1918965..1920353) Corynebacterium diphtheriae NCTC 13129 2649251 NP_940214.1 CDS DIP1877 NC_002935.2 1920343 1921635 R No significant database matches to the full length CDS. C-terminus is similar to the N-terminal regions of Rhizobium meliloti hypothetical protein SMA0447 TR:AAK64892 (EMBL:AE007216) (373 aa) fasta scores: E(): 0.48, 22.94% id in 353 aa; hypothetical protein complement(1920343..1921635) Corynebacterium diphtheriae NCTC 13129 2649252 NP_940215.1 CDS DIP1878 NC_002935.2 1921639 1922748 R Poor database matches. C-terminal region is weakly similar to Sulfolobus solfataricus hypothetical protein Sso2014 sso2014 TR:Q97WV0 (EMBL:AE006808) (307 aa) fasta scores: E(): 0.44, 21.34% id in 328 aa; hypothetical protein complement(1921639..1922748) Corynebacterium diphtheriae NCTC 13129 2649253 NP_940216.1 CDS DIP1879 NC_002935.2 1922840 1923505 D Similar to Mycobacterium tuberculosis hypothetical protein Rv2621c TR:O06191 (EMBL:Z95387) (224 aa) fasta scores: E(): 2.3e-05, 27.12% id in 188 aa, and to Deinococcus radiodurans conserved hypothetical protein DR0999 TR:Q9RvM8 (EMBL:AE001952) (225 aa) fasta scores: E(): 0.01, 23.62% id in 182 aa; DNA-binding protein 1922840..1923505 Corynebacterium diphtheriae NCTC 13129 2649254 NP_940217.1 CDS DIP1880 NC_002935.2 1923706 1924440 R Poor database matches. Weakly similar to Streptomyces coelicolor hypothetical protein SC4G6.36 TR:Q9S2S3 (EMBL:AL096884) (266 aa) fasta scores: E(): 4.7e-06, 26.22% id in 225 aa, and to Mycobacterium leprae possible conserved membrane protein ML1667 TR:Q9CBS4 (EMBL:AL583923) (264 aa) fasta scores: E(): 1.5e-05, 28.77% id in 212 aa; hypothetical protein complement(1923706..1924440) Corynebacterium diphtheriae NCTC 13129 2649256 NP_940218.1 CDS DIP1881 NC_002935.2 1924490 1924942 R Poor database matches. Similar to the N-terminal regions of Paracoccus denitrificans methylamine utilization protein MauE SW:MAUE_PARDE (P29896) (186 aa) fasta scores: E(): 0.00023, 30.89% id in 123 aa, and Methylobacterium extorquens methylamine utilization protein MauE SW:MAUE_METEX (Q49125) (187 aa) fasta scores: E(): 0.026, 29% id in 100 aa; hypothetical protein complement(1924490..1924942) Corynebacterium diphtheriae NCTC 13129 2649257 NP_940219.1 CDS pgm NC_002935.2 1924981 1926618 R catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase complement(1924981..1926618) Corynebacterium diphtheriae NCTC 13129 2649258 NP_940220.1 CDS ccrB NC_002935.2 1926684 1926971 D may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 1926684..1926971 Corynebacterium diphtheriae NCTC 13129 2649259 NP_940221.1 CDS DIP1884 NC_002935.2 1926968 1927282 D Similar to Streptococcus pneumoniae CrcB protein SP1294 TR:AAK75398 (EMBL:AE007428) (109 aa) fasta scores: E(): 7.4e-06, 33.33% id in 108 aa, and to Bacillus subtilis protein CrcB homolog 1 CrcB1 TR:O07590 (EMBL:Y14082) (118 aa) fasta scores: E(): 0.033, 29.56% id in 115 aa; hypothetical protein 1926968..1927282 Corynebacterium diphtheriae NCTC 13129 2649260 NP_940222.1 CDS DIP1885 NC_002935.2 1927279 1929843 R Similar to Streptomyces coelicolor ABC transport system integral membrane protein SCE41.19c TR:Q9F2P0 (EMBL:AL442120) (854 aa) fasta scores: E(): 6.5e-62, 30.8% id in 870 aa, and to Streptomyces coelicolor ABC transporter integral membrane protein SCE25.31 TR:Q9KZ59 (EMBL:AL354048) (843 aa) fasta scores: E(): 2.6e-41, 33.83% id in 857 aa; ABC transporter permease complement(1927279..1929843) Corynebacterium diphtheriae NCTC 13129 2649261 NP_940223.1 CDS DIP1886 NC_002935.2 1929844 1930593 R Similar to Streptomyces coelicolor ABC transport system ATP-binding protein SCE41.20c TR:Q9F2N9 (EMBL:AL442120) (262 aa) fasta scores: E(): 9.4e-54, 63.9% id in 241 aa, and to Streptomyces coelicolor ABC transporter ATP-binding protein SCE25.30 TR:Q9KZ60 (EMBL:AL354048) (256 aa) fasta scores: E(): 4.6e-53, 67.37% id in 236 aa; ABC transporter ATP-binding protein complement(1929844..1930593) Corynebacterium diphtheriae NCTC 13129 2649262 NP_940224.1 CDS murA NC_002935.2 1937107 1938363 R adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase complement(1937107..1938363) Corynebacterium diphtheriae NCTC 13129 2649266 NP_940225.1 CDS DIP1888 NC_002935.2 1938402 1938977 D Similar to Mycobacterium tuberculosis hypothetical protein Rv1314c SW:YD14_MYCTU (Q10622) (193 aa) fasta scores: E(): 3.1e-50, 70.15% id in 191 aa, and to Mycobacterium leprae hypothetical protein ML1149 SW:YD14_MYCLE (P53523) (191 aa) fasta scores: E(): 1e-47, 65.96% id in 191 aa; hypothetical protein 1938402..1938977 Corynebacterium diphtheriae NCTC 13129 2649267 NP_940226.1 CDS DIP1889 NC_002935.2 1939030 1939875 R Similar to Streptomyces coelicolor transcriptional regulator SC2G5.15C TR:Q9Z5A8 (EMBL:AL035478) (279 aa) fasta scores: E(): 9.5e-35, 44.89% id in 274 aa, and to Rhizobium meliloti transcription regulator protein SMC03015 TR:CAC45219 (EMBL:AL591784) (245 aa) fasta scores: E(): 0.012, 25.55% id in 227 aa; transcriptional regulator complement(1939030..1939875) Corynebacterium diphtheriae NCTC 13129 2649268 NP_940227.1 CDS DIP1890 NC_002935.2 1940558 1941493 D Similar to the C-terminal region of Arabidopsis thaliana cysteine synthase, mitochondrial precursor ACS 1 SW:CYSM_ARATH (Q43725) (424 aa) fasta scores: E(): 1.5e-58, 53.39% id in 309 aa, and to the full length Neisseria meningitidis (serogroup A) cysteine synthase NMA0974 TR:Q9JQL6 (EMBL:AL162754) (310 aa) fasta scores: E(): 5.6e-65, 59.09% id in 308 aa; cysteine synthase 1940558..1941493 Corynebacterium diphtheriae NCTC 13129 2649269 NP_940228.1 CDS cysE NC_002935.2 1941600 1942166 D Similar to Staphylococcus xylosus serine acetyltransferase CysE SW:CYSE_STAXY (P77985) (216 aa) fasta scores: E(): 9.3e-33, 55.68% id in 167 aa, and to Azotobacter vinelandii O-acetylserine synthase CysE2 TR:O69218 (EMBL:AF010139) (251 aa) fasta scores: E(): 6.1e-38, 58.85% id in 175 aa; serine acetyltransferase 1941600..1942166 Corynebacterium diphtheriae NCTC 13129 2649270 NP_940229.1 CDS DIP1892 NC_002935.2 1942208 1942489 R Similar to Streptomyces coelicolor conserved hypothetical protein SC8D11.21 TR:Q9AJZ8 (EMBL:AL512944) (112 aa) fasta scores: E(): 1.5e-08, 40% id in 85 aa, and to Streptomyces coelicolor conserved hypothetical protein SC8D11.19 TR:Q9AK00 (EMBL:AL512944) (102 aa) fasta scores: E(): 1.9e-05, 32.96% id in 91 aa; hypothetical protein complement(1942208..1942489) Corynebacterium diphtheriae NCTC 13129 2649271 NP_940230.1 CDS DIP1893 NC_002935.2 1942871 1943947 R Similar to Escherichia coli glycerol dehydrogenase GldA SW:GLDA_ECOLI (P32665) (367 aa) fasta scores: E(): 6.1e-21, 29% id in 331 aa, and to Streptococcus pneumoniae glycerol dehydrogenase SP0253 TR:AAK74432 (EMBL:AE007338) (362 aa) fasta scores: E(): 3e-22, 29.64% id in 361 aa; hypothetical protein complement(1942871..1943947) Corynebacterium diphtheriae NCTC 13129 2649273 NP_940231.1 CDS DIP1894 NC_002935.2 1944430 1947027 R No significant database matches to the full length CDS. Internal region is weakly similar to an internal region of Thermoplasma volcanium hypothetical protein TVG1552703 TR:BAB60643 (EMBL:AP000996) (974 aa) fasta scores: E(): 5.5e-05, 21.86% id in 773 aa; hypothetical protein complement(1944430..1947027) Corynebacterium diphtheriae NCTC 13129 2648943 NP_940232.1 CDS DIP1895 NC_002935.2 1947027 1948868 R Internal region is similar to an internal regions of Salmonella typhimurium type III restriction-modification system StyLTI enzyme Mod SW:T3MO_SALTY (P40814) (651 aa) fasta scores: E(): 1.8e-20, 29.39% id in 398 aa, and Xylella fastidiosa methyltransferase XF1968 TR:Q9PC17 (EMBL:AE004016) (534 aa) fasta scores: E(): 5.9e-33, 35.25% id in 417 aa; DNA methylase complement(1947027..1948868) Corynebacterium diphtheriae NCTC 13129 2648944 NP_940233.1 CDS DIP1896 NC_002935.2 1949307 1949477 D Similar to the C-terminal regions of Saccharopolyspora sp. transposase SapX TR:O52713 (EMBL:AF045021) (103 aa) fasta scores: E(): 0.00038, 45.83% id in 48 aa, and Streptomyces lividans similar to Orf1 of the IS3 family TR:Q54335 (EMBL:U50076) (103 aa) fasta scores: E(): 0.076, 47.61% id in 42 aa; transposase (partial) 1949307..1949477 Corynebacterium diphtheriae NCTC 13129 2648945 NP_940234.1 CDS DIP1897 NC_002935.2 1949524 1949853 D Similar to N-terminal region of Corynebacterium jeikeium transposase B TnpB TR:AAK67710 (EMBL:AY036070) (302 aa) fasta scores: E(): 4.1e-08, 40% id in 100 aa. Probable gene remnant; transposase (partial) 1949524..1949853 Corynebacterium diphtheriae NCTC 13129 2648946 NP_940235.1 CDS DIP1898 NC_002935.2 1950742 1952253 D N-terminus is similar to the N-terminal region of Escherichia coli cytochrome D ubiquinol oxidase subunit I CydA SW:CYDA_ECOLI (P11026) (522 aa) fasta scores: E(): 5.2e-47, 37.11% id in 485 aa. Similar to Mycobacterium tuberculosis probable cytochrome D ubiquinol oxidase subunit Rv1623c TR:O06140 (EMBL:Z95554) (485 aa) fasta scores: E(): 4.5e-121, 62.11% id in 483 aa; cytochrome ubiquinol oxidase subunit 1950742..1952253 Corynebacterium diphtheriae NCTC 13129 2648948 NP_940236.1 CDS DIP1899 NC_002935.2 1952261 1953235 D Similar to Escherichia coli cytochrome D ubiquinol oxidase subunit II CydB SW:CYDB_ECOLI (P11027) (379 aa) fasta scores: E(): 9.8e-28, 37.63% id in 364 aa, and to Corynebacterium glutamicum cytochrome BD-type menaquinol oxidase subunit II CydB TR:Q9KWL7 (EMBL:AB035086) (334 aa) fasta scores: E(): 3.4e-63, 54.26% id in 328 aa; cytochrome ubiquinol oxidase subunit 1952261..1953235 Corynebacterium diphtheriae NCTC 13129 2648949 NP_940237.1 CDS DIP1900 NC_002935.2 1953232 1954803 D Similar to Bacillus subtilis transport ATP-binding protein CydC SW:CYDC_BACSU (P94366) (567 aa) fasta scores: E(): 2.3e-21, 31.8% id in 544 aa, and to Vibrio cholerae transport ATP-binding protein VC1181 TR:Q9KSS5 (EMBL:AE004198) (595 aa) fasta scores: E(): 2.5e-19, 27.76% id in 551 aa. CDS is extended at the N-terminus in comparison to similar proteins. Possible alternative translational start site; ABC transporter ATP-binding protein 1953232..1954803 Corynebacterium diphtheriae NCTC 13129 2648950 NP_940238.1 CDS DIP1901 NC_002935.2 1954800 1956347 D Similar to Mycobacterium tuberculosis Rv1620c TR:O06137 (EMBL:Z95554) (576 aa) fasta scores: E(): 2.2e-20, 38.71% id in 527 aa, and to Caulobacter crescentus ABC transporter, ATP-binding protein CC0761 TR:Q9AA45 (EMBL:AE005752) (546 aa) fasta scores: E(): 5.8e-16, 28.73% id in 529 aa; ABC transporter ATP-binding protein 1954800..1956347 Corynebacterium diphtheriae NCTC 13129 2648951 NP_940239.1 CDS cat1 NC_002935.2 1956426 1957979 R Similar to Clostridium kluyveri succinyl-CoA:coenzyme A transferase Cat1 SWALL:CAT1_CLOKL (SWALL:P38946) (538 aa) fasta scores: E(): 1.8e-85, 47.56% id in 513 aa, and to Caulobacter crescentus coenzyme A transferase, CC3724 SWALL:Q9A242 (EMBL:AE006030) (514 aa) fasta scores: E(): 1.3e-97, 52.96% id in 506 aa; succinyl-CoA:coenzyme A transferase complement(1956426..1957979) Corynebacterium diphtheriae NCTC 13129 2648952 NP_940240.1 CDS DIP1903 NC_002935.2 1958274 1959425 D Similar to Mycobacterium tuberculosis hypothetical protein Rv0823c SW:Y823_MYCTU (O53835) (389 aa) fasta scores: E(): 4.4e-98, 65.69% id in 379 aa, and to Streptomyces coelicolor hypothetical protein SCC82.03c TR:Q9RDC6 (EMBL:AL133471) (406 aa) fasta scores: E(): 3.6e-62, 53.75% id in 400 aa; hypothetical protein 1958274..1959425 Corynebacterium diphtheriae NCTC 13129 2648953 NP_940241.1 CDS DIP1904 NC_002935.2 1959444 1960196 D Similar to Mycobacterium tuberculosis phosphate transport system protein PhoU homolog 2 Rv0821c SW:PHU2_MYCTU (O53833) (213 aa) fasta scores: E(): 2.1e-32, 42.72% id in 213 aa, and to Mycobacterium leprae phosphate transport system protein PhoU homolog 1 ML2188 SW:PHU1_MYCLE (Q50047) (222 aa) fasta scores: E(): 8.5e-31, 40.93% id in 215 aa; hypothetical protein 1959444..1960196 Corynebacterium diphtheriae NCTC 13129 2648954 NP_940242.1 CDS DIP1905 NC_002935.2 1960346 1960558 R Doubtful CDS. No significant database matches; hypothetical protein complement(1960346..1960558) Corynebacterium diphtheriae NCTC 13129 2648955 NP_940243.1 CDS pstA NC_002935.2 1961506 1962369 R Similar to Escherichia coli phosphate transport system permease PstA SW:PSTA_ECOLI (P07654) (296 aa) fasta scores: E(): 5.5e-27, 35.48% id in 279 aa, and to Mycobacterium tuberculosis phosphate transport system permease Rv0930 TR:AAK45204 (EMBL:X75297) (304 aa) fasta scores: E(): 1.3e-48, 47.65% id in 277 aa. CDS contains a truncated N-terminus in comparison to othologues; phosphate ABC transporter permease complement(1961506..1962369) Corynebacterium diphtheriae NCTC 13129 2648957 NP_940244.1 CDS pstC NC_002935.2 1962383 1963408 R Similar to Escherichia coli, and phosphate transport system permease PstC SW:PSTC_ECOLI (P07653) (319 aa) fasta scores: E(): 3.5e-26, 32.69% id in 312 aa, and to Mycobacterium tuberculosis phosphate transport system permease Rv0929 TR:O86344 (EMBL:Z47983) (324 aa) fasta scores: E(): 2.8e-43, 46.12% id in 310 aa; phosphate ABC transporter permease complement(1962383..1963408) Corynebacterium diphtheriae NCTC 13129 2648958 NP_940245.1 CDS DIP1910 NC_002935.2 1963421 1964506 R Similar to Escherichia coli phosphate-binding periplasmic protein precursor PstS SW:PSTS_ECOLI (P06128) (346 aa) fasta scores: E(): 5e-20, 29.16% id in 360 aa, and to Mycobacterium avium phosphate-binding protein 3 precursor PstS3 TR:Q9KK89 (EMBL:AF137360) (369 aa) fasta scores: E(): 4.6e-50, 42.23% id in 367 aa; phosphate-binding periplasmic protein complement(1963421..1964506) Corynebacterium diphtheriae NCTC 13129 2648959 NP_940246.1 CDS DIP1911 NC_002935.2 1964778 1965689 R Similar to Mycobacterium leprae acetyltransferase ML2193 TR:Q9CBC9 (EMBL:AL583924) (311 aa) fasta scores: E(): 3.4e-22, 35.5% id in 307 aa, and to Mycobacterium tuberculosis hypothetical protein Rv0819 TR:O53831 (EMBL:AL022004) (315 aa) fasta scores: E(): 6e-19, 33.33% id in 312 aa; acetyltransferase complement(1964778..1965689) Corynebacterium diphtheriae NCTC 13129 2648960 NP_940247.1 CDS DIP1912 NC_002935.2 1965728 1966531 D Poor database matches. Similar to Mycobacterium leprae probable exported protein ML2195 TR:Q50040 (EMBL:U15182) (283 aa) fasta scores: E(): 0.44, 23.39% id in 265 aa; hypothetical protein 1965728..1966531 Corynebacterium diphtheriae NCTC 13129 2648961 NP_940248.1 CDS DIP1913 NC_002935.2 1966561 1967583 R Similar to Mycobacterium tuberculosis hypothetical protein Rv3218 TR:O05848 (EMBL:Z95120) (321 aa) fasta scores: E(): 1.1e-27, 33.43% id in 329 aa, and to Streptomyces coelicolor hypothetical protein 2SC7G11.03c TR:Q9F3M0 (EMBL:AL391763) (322 aa) fasta scores: E(): 2.2e-22, 37.69% id in 329 aa; hypothetical protein complement(1966561..1967583) Corynebacterium diphtheriae NCTC 13129 2648962 NP_940249.1 CDS DIP1915 NC_002935.2 1967623 1968300 D Similar to Mycobacterium tuberculosis hypothetical protein Rv0813c TR:O53827 (EMBL:AL022004) (226 aa) fasta scores: E(): 2.9e-33, 45.97% id in 211 aa, and to Mycobacterium leprae hypothetical protein ML2200 TR:Q9CBC6 (EMBL:AL583924) (228 aa) fasta scores: E(): 4.3e-32, 43.66% id in 229 aa; hypothetical protein 1967623..1968300 Corynebacterium diphtheriae NCTC 13129 2648963 NP_940250.1 CDS DIP1916 NC_002935.2 1968307 1969203 R catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; 4-amino-4-deoxychorismate lyase complement(1968307..1969203) Corynebacterium diphtheriae NCTC 13129 2648964 NP_940251.1 CDS DIP1917 NC_002935.2 1969299 1970360 D Similar to Corynebacterium ammoniagenes hypothetical protein Orf4 TR:Q9RHX9 (EMBL:AB003158) (359 aa) fasta scores: E(): 7.6e-61, 49.17% id in 362 aa, and to Mycobacterium tuberculosis hypothetical protein Rv0811c TR:O53825 (EMBL:AL022004) (368 aa) fasta scores: E(): 7.9e-11, 42.29% id in 357 aa; hypothetical protein 1969299..1970360 Corynebacterium diphtheriae NCTC 13129 2648965 NP_940252.1 CDS DIP1918 NC_002935.2 1970581 1970787 D Similar to Mycobacterium tuberculosis hypothetical protein Rv0810c TR:O53824 (EMBL:AL022004) (60 aa) fasta scores: E(): 9.9e-07, 49.23% id in 65 aa, and to Streptomyces coelicolor hypothetical protein SCD25.24c TR:Q9RKJ8 (EMBL:AL118514) (84 aa) fasta scores: E(): 2.1e-07, 52.23% id in 67 aa; hypothetical protein 1970581..1970787 Corynebacterium diphtheriae NCTC 13129 2648966 NP_940253.1 CDS purM NC_002935.2 1970918 1971982 R catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase complement(1970918..1971982) Corynebacterium diphtheriae NCTC 13129 2648967 NP_940254.1 CDS purF NC_002935.2 1972042 1973523 R Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase complement(1972042..1973523) Corynebacterium diphtheriae NCTC 13129 2648968 NP_940255.1 CDS DIP1921 NC_002935.2 1973657 1974052 R Similar to Corynebacterium ammoniagenes hypothetical protein Orf3 TR:Q9RHY2 (EMBL:AB003158) (132 aa) fasta scores: E(): 4.5e-26, 61.15% id in 121 aa, and to Mycobacterium tuberculosis hypothetical protein Rv0807 TR:O06627 (EMBL:Z95618) (129 aa) fasta scores: E(): 2.3e-24, 57.48% id in 127 aa; hypothetical protein complement(1973657..1974052) Corynebacterium diphtheriae NCTC 13129 2648969 NP_940256.1 CDS DIP1922 NC_002935.2 1974391 1975179 R Similar to Corynebacterium ammoniagenes hypothetical protein Orf1 TR:Q9RHY4 (EMBL:AB003158) (245 aa) fasta scores: E(): 3.5e-52, 56.65% id in 233 aa, and to Streptomyces coelicolor conserved hypothetical membrane protein 2SCK36.01c TR:CAC40591 (EMBL:AL591857) (234 aa) fasta scores: E(): 2.2e-26, 38.62% id in 233 aa; hypothetical protein complement(1974391..1975179) Corynebacterium diphtheriae NCTC 13129 2648970 NP_940257.1 CDS nrdI NC_002935.2 1975317 1975742 D in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 1975317..1975742 Corynebacterium diphtheriae NCTC 13129 2648971 NP_940258.1 CDS nrdF NC_002935.2 1975739 1976764 D B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 1975739..1976764 Corynebacterium diphtheriae NCTC 13129 2648972 NP_940259.1 CDS DIP1925 NC_002935.2 1978463 1978933 R Similar to Caulobacter crescentus glutathione peroxidase CC1730 TR:Q9A7J3 (EMBL:AE005847) (160 aa) fasta scores: E(): 9.7e-24, 45.39% id in 152 aa, and to Pseudomonas aeruginosa glutathione peroxidase PA0838 TR:Q9I5A2 (EMBL:AE004518) (160 aa) fasta scores: E(): 9.7e-24, 44.15% id in 154 aa; glutathione peroxidase complement(1978463..1978933) Corynebacterium diphtheriae NCTC 13129 2648974 NP_940260.1 CDS DIP1926 NC_002935.2 1978935 1981064 R Similar to Mycobacterium tuberculosis CDC1551 protease II MT0805 TR:AAK45047 (EMBL:AE006971) (718 aa) fasta scores: E(): 1.1e-159, 55.68% id in 695 aa, and to Mycobacterium leprae ML2226 TR:O05748 (EMBL:Z95151) (724 aa) fasta scores: E(): 8.2e-148, 52.36% id in 699 aa; prolyl oligopeptidase complement(1978935..1981064) Corynebacterium diphtheriae NCTC 13129 2648975 NP_940261.1 CDS hemH NC_002935.2 1981355 1982248 R catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazolesuccinocarboxamide synthase complement(1981355..1982248) Corynebacterium diphtheriae NCTC 13129 2648976 NP_940262.1 CDS purB NC_002935.2 1982334 1983773 R Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase complement(1982334..1983773) Corynebacterium diphtheriae NCTC 13129 2648977 NP_940263.1 CDS DIP1929 NC_002935.2 1983773 1984909 R Similar to Thermus aquaticus aspartate aminotransferase AspC SW:AAT_THETH (Q56232) (385 aa) fasta scores: E(): 1.1e-29, 32.95% id in 352 aa, and to Mycobacterium tuberculosis hypothetical protein Rv3565 TR:P96847 (EMBL:Z92774) (388 aa) fasta scores: E(): 6.4e-68, 48.15% id in 380 aa; aspartate aminotransferase complement(1983773..1984909) Corynebacterium diphtheriae NCTC 13129 2648978 NP_940264.1 CDS DIP1930 NC_002935.2 1984920 1985576 R Similar to Bacillus halodurans potassium uptake protein BH2663 TR:Q9K9I4 (EMBL:AP001516) (220 aa) fasta scores: E(): 1.2e-20, 34.29% id in 207 aa, and to Staphylococcus aureus (strain N315) hypothetical protein SA0939 TR:Q99V10 (EMBL:AP003132) (220 aa) fasta scores: E(): 4.6e-20, 35.09% id in 208 aa; hypothetical protein complement(1984920..1985576) Corynebacterium diphtheriae NCTC 13129 2648979 NP_940265.1 CDS DIP1931 NC_002935.2 1985569 1986903 R Similar to Enterococcus hirae V-type sodium ATP synthase subunit J NtpJ SW:NTPJ_ENTHR (P43440) (451 aa) fasta scores: E(): 3.8e-45, 36.94% id in 452 aa, and to Synechocystis sp Na+-ATPase subunit J SLR1509 TR:P73949 (EMBL:D90911) (444 aa) fasta scores: E(): 4.3e-49, 39.68% id in 446 aa; sodium transport protein complement(1985569..1986903) Corynebacterium diphtheriae NCTC 13129 2648980 NP_940266.1 CDS purD NC_002935.2 1986987 1988273 R catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase complement(1986987..1988273) Corynebacterium diphtheriae NCTC 13129 2648981 NP_940267.1 CDS DIP1933 NC_002935.2 1988352 1988777 D Similar to Rhodococcus sp. S9 HIT-like protein TR:Q9L4T6 (EMBL:AF265258) (141 aa) fasta scores: E(): 1.4e-24, 52.98% id in 134 aa, and to Mycobacterium leprae hypothetical HIT-like protein ML2237 SW:YHI1_MYCLE (P49774) (134 aa) fasta scores: E(): 1.1e-23, 50.37% id in 133 aa; HIT family protein 1988352..1988777 Corynebacterium diphtheriae NCTC 13129 2648982 NP_940268.1 CDS DIP1934 NC_002935.2 1988794 1989459 D No significant database matches to the full length CDS. C-terminus is similar to the C-terminal regions of Streptomyces coelicolor secreted lipase SCD63A.10c TR:Q9KY65 (EMBL:AL356832) (331 aa) fasta scores: E(): 0.00018, 31.3% id in 214 aa, and Streptomyces coelicolor lipase 2SCG18.12c TR:Q9K3H5 (EMBL:AL390188) (289 aa) fasta scores: E(): 0.00064, 28.94% id in 190 aa; hypothetical protein 1988794..1989459 Corynebacterium diphtheriae NCTC 13129 2648983 NP_940269.1 CDS DIP1935 NC_002935.2 1989473 1991032 R C-terminal region is similar to Mycobacterium tuberculosis hypothetical protein Rv0758 TR:P71815 (EMBL:Z80226) (485 aa) fasta scores: E(): 7.7e-38, 42.88% id in 471 aa, and to Bacillus halodurans two-component sensor histidine kinase BH0373 TR:Q9KFU8 (EMBL:AP001508) (459 aa) fasta scores: E(): 3.7e-29, 30.81% id in 464 aa; two somponent system sensor kinase complement(1989473..1991032) Corynebacterium diphtheriae NCTC 13129 2648984 NP_940270.1 CDS DIP1936 NC_002935.2 1991068 1991778 R Similar to Bacillus subtilis alkaline phosphatase synthesis transcriptional regulatory protein PhoP SW:PHOP_BACSU (P13792) (240 aa) fasta scores: E(): 1.3e-32, 42.37% id in 236 aa, and to Mycobacterium tuberculosis hypothetical PhoP-like protein Rv0757 TR:AAK45023 (EMBL:Z80226) (240 aa) fasta scores: E(): 3.2e-57, 66.37% id in 226 aa; two component system response regulator protein complement(1991068..1991778) Corynebacterium diphtheriae NCTC 13129 2648985 NP_940271.1 CDS DIP1937 NC_002935.2 1992160 1992726 D Poor database matches. Similar to the C-terminal region of Bacillus subtilis extracellular metalloprotease precursor Mpr SW:MPR_BACSU (P39790) (313 aa) fasta scores: E(): 8.9, 23.76% id in 202 aa; hypothetical protein 1992160..1992726 Corynebacterium diphtheriae NCTC 13129 2648986 NP_940272.1 CDS DIP1938 NC_002935.2 1992696 1992968 D hypothetical protein 1992696..1992968 Corynebacterium diphtheriae NCTC 13129 2648987 NP_940273.1 CDS DIP1939 NC_002935.2 1992968 1993156 D Similar to the N-terminus of Thermotoga maritima conserved hypothetical protein TM1156 TR:Q9X0P0 (EMBL:AE001773) (129 aa) fasta scores: E(): 5.1e-05, 39.34% id in 61 aa, and to the full length Bacillus subtilis hypothetical protein YvlC TR:O34719 (EMBL:AF017113) (65 aa) fasta scores: E(): 0.00018, 41.37% id in 58 aa; hypothetical protein 1992968..1993156 Corynebacterium diphtheriae NCTC 13129 2648988 NP_940274.1 CDS DIP1940 NC_002935.2 1993265 1993411 D Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 1993265..1993411 Corynebacterium diphtheriae NCTC 13129 2648989 NP_940275.1 CDS DIP1941 NC_002935.2 1993436 1994935 D Similar to Salmonella typhimurium methyl viologen resistance protein SmvA SW:SMVA_SALTY (P37594) (496 aa) fasta scores: E(): 4e-41, 33.4% id in 488 aa, and to Pseudomonas aeruginosa probable MFS transporter PA1282 TR:Q9I462 (EMBL:AE004557) (501 aa) fasta scores: E(): 1.2e-55, 41.17% id in 493 aa; hypothetical protein 1993436..1994935 Corynebacterium diphtheriae NCTC 13129 2648990 NP_940276.1 CDS DIP1942 NC_002935.2 1994922 1995542 D Similar to Synechocystis sp hypothetical protein SLR0895 TR:Q55363 (EMBL:D64003) (187 aa) fasta scores: E(): 6.6e-05, 24% id in 175 aa, and to Rhizobium meliloti hypothetical protein SMC01522 TR:CAC46995 (EMBL:AL591790) (186 aa) fasta scores: E(): 7.7e-05, 25.88% id in 170 aa; TetR family regulatory protein 1994922..1995542 Corynebacterium diphtheriae NCTC 13129 2648991 NP_940277.1 CDS DIP1943 NC_002935.2 1995598 1997511 D Similar to Streptomyces coelicolor permease SC9G1.04 TR:Q9RKW2 (EMBL:AL132997) (462 aa) fasta scores: E(): 5.6e-61, 41.93% id in 465 aa, and to Escherichia coli purine permease YgfU SW:YGFU_ECOLI (Q46821) (482 aa) fasta scores: E(): 9e-55, 38.08% id in 449 aa; xanthine/uracil permeases family protein 1995598..1997511 Corynebacterium diphtheriae NCTC 13129 2648992 NP_940278.1 CDS tnpA2 NC_002935.2 1998063 1998857 D Almost identical to Salmonella enterica subsp enterica serovar Typhimurium transposase TnpA TR:Q9FDH9 (EMBL:AF261825) (264 aa) fasta scores: E(): 7e-112, 99.62% id in 264 aa, and to Mycobacterium fortuitum transposase Tnp TR:Q49185 (EMBL:X53635) (254 aa) fasta scores: E(): 6.7e-107, 99.6% id in 254 aa. Note: This CDS is duplicated downstream in CDIP1951 (264 aa) fasta scores: E(): 2.7e-119, 100.000% identity in 264 aa overlap; transposase 1998063..1998857 Corynebacterium diphtheriae NCTC 13129 2648993 NP_940279.1 CDS DIP1947 NC_002935.2 1998829 1999494 R N-terminus is identical to the N-terminal regions of Mycobacterium fortuitum integrase Orf2M TR:Q49186 (EMBL:X53635) (303 aa) fasta scores: E(): 3.6e-79, 100% id in 194 aa, and Acinetobacter baumannii integraseTtnp1 TR:AAA56784 (EMBL:U17586) (337 aa) fasta scores: E(): 4e-79, 100% id in 194 aa; integrase complement(1998829..1999494) Corynebacterium diphtheriae NCTC 13129 2648994 NP_940280.1 CDS DIP1948 NC_002935.2 1999595 2000446 D Almost identical to Escherichia coli dihydropteroate synthase type I SulI SW:DHP1_ECOLI (P11744) (279 aa) fasta scores: E(): 3.1e-105, 99.64% id in 278 aa, and to Corynebacterium glutamicum sufamethoxazole resistance protein SulI TR:AAG00283 (EMBL:AF164956) (279 aa) fasta scores: E(): 3.1e-105, 99.64% id in 278 aa. Orthologues are implicated in resistance to sulfonamide and are located on various large self-transmissible plasmids and transposons related to Tn21; dihydropteroate synthase 1999595..2000446 Corynebacterium diphtheriae NCTC 13129 2648995 NP_940281.1 CDS DIP1949 NC_002935.2 2000574 2001074 D Identical to Escherichia coli hypothetical protein YbbA TR:P75025 (EMBL:U12441) (166 aa) fasta scores: E(): 1.6e-70, 100% id in 166 aa, and to Acinetobacter baumannii hypothetical protein TR:AAK72477 (EMBL:AY038837) (142 aa) fasta scores: E(): 4.2e-59, 100% id in 142 aa; acetyltransferase 2000574..2001074 Corynebacterium diphtheriae NCTC 13129 2648996 NP_940282.1 CDS DIP1950 NC_002935.2 2001098 2001385 D Poor database matches. Identical to Salmonella enterica subsp enterica serovar Typhimurium hypothetical protein TR:Q9FDI0 (EMBL:AF261825) (95 aa) fasta scores: E(): 3.9e-37, 100% id in 95 aa; hypothetical protein 2001098..2001385 Corynebacterium diphtheriae NCTC 13129 2648997 NP_940283.1 CDS tnpA3 NC_002935.2 2001551 2002345 D Almost identical to Salmonella enterica subsp enterica serovar Typhimurium transposase TnpA TR:Q9FDH9 (EMBL:AF261825) (264 aa) fasta scores: E(): 6.6e-112, 99.62% id in 264 aa, and Mycobacterium fortuitum transposase Tnp TR:Q49185 (EMBL:X53635) (254 aa) fasta scores: E(): 6.4e-107, 99.6% id in 254 aa, Note: This CDS is duplicated upstream in CDIP1944 (264 aa) fasta scores: E(): 2.7e-119, 100.000% identity in 264 aa overlap; transposase 2001551..2002345 Corynebacterium diphtheriae NCTC 13129 2648998 NP_940284.1 CDS DIP1952 NC_002935.2 2002457 2004193 R catalyzes the formation of acetate from pyruvate; pyruvate dehydrogenase complement(2002457..2004193) Corynebacterium diphtheriae NCTC 13129 2648999 NP_940285.1 CDS DIP1953 NC_002935.2 2004306 2005757 D Similar to Corynebacterium glutamicum threonine export carrier protein ThrE TR:AAK61331 (EMBL:AF326510) (489 aa) fasta scores: E(): 3.8e-75, 48.76% id in 445 aa, and to Mycobacterium tuberculosis membrane protein Rv3737 TR:O69704 (EMBL:AL022121) (529 aa) fasta scores: E(): 2.2e-29, 31.15% id in 414 aa. Note: Also similar to DIP1964 (514 aa) fasta scores: E(): 7.1e-58, 44.662% identity in 459 aa overlap; amino acid export carrier protein 2004306..2005757 Corynebacterium diphtheriae NCTC 13129 2649000 NP_940286.1 CDS DIP1955 NC_002935.2 2006198 2007007 R Similar to Escherichia coli transposase for insertion sequence element IS150, InsK SW:INSK_ECOLI (P19769) (283 aa) fasta scores: E(): 3.2e-41, 43.23% id in 266 aa, and to Klebsiella pneumoniae hypothetical protein OrfB TR:Q9AG21 (EMBL:AF345899) (281 aa) fasta scores: E(): 1.3e-42, 45.45% id in 264 aa. CDS contains fewer amino acids at the N-terminus in comparison to orthologues; transposase complement(2006198..2007007) Corynebacterium diphtheriae NCTC 13129 2649001 NP_940287.1 CDS DIP1956 NC_002935.2 2007058 2007495 R C-terminal regions is similar to Streptococcus agalactiae hypothetical protein TR:Q53639 (EMBL:M22449) (141 aa) fasta scores: E(): 1.3e-06, 32.43% id in 111 aa, and to Marinococcus halophilus transposase TR:O06062 (EMBL:U66614) (110 aa) fasta scores: E(): 0.051, 27.18% id in 103 aa; hypothetical protein complement(2007058..2007495) Corynebacterium diphtheriae NCTC 13129 2649002 NP_940288.1 CDS DIP1957 NC_002935.2 2007631 2007888 R hypothetical protein complement(2007631..2007888) Corynebacterium diphtheriae NCTC 13129 2649003 NP_940289.1 CDS DIP1958 NC_002935.2 2008028 2008507 D DNA-binding protein 2008028..2008507 Corynebacterium diphtheriae NCTC 13129 2649004 NP_940290.1 CDS DIP1959 NC_002935.2 2008563 2008877 D Poor database matches. Similar to the C-terminal region of Bacillus halodurans hypothetical protein BH3550 TR:Q9K723 (EMBL:AP001519) (146 aa) fasta scores: E(): 0.85, 32.03% id in 103 aa; hypothetical protein 2008563..2008877 Corynebacterium diphtheriae NCTC 13129 2649005 NP_940291.1 CDS DIP1960 NC_002935.2 2009016 2009465 D C-terminus is similar to the C-terminal region of Bacillus subtilis hypothetical protein YqxI SW:YQXI_BACSU (P24812) (159 aa) fasta scores: E(): 7.6, 26.04% id in 96 aa; hypothetical protein 2009016..2009465 Corynebacterium diphtheriae NCTC 13129 2649006 NP_940292.1 CDS DIP1961 NC_002935.2 2009462 2009800 D hypothetical protein 2009462..2009800 Corynebacterium diphtheriae NCTC 13129 2649007 NP_940293.1 CDS DIP1962 NC_002935.2 2009896 2010234 R hypothetical protein complement(2009896..2010234) Corynebacterium diphtheriae NCTC 13129 2649008 NP_940294.1 CDS DIP1963 NC_002935.2 2010331 2011782 D Similar to Escherichia coli possible transposase of IS1353 YahA TR:Q9WTH9 (EMBL:AP000342) (514 aa) fasta scores: E(): 1.7e-62, 41.81% id in 464 aa, and to Agrobacterium tumefaciens str. C58 possible transposase of IS1353 AGR_C_3822 TR:AAK87856 (EMBL:AE008127) (512 aa) fasta scores: E(): 2.7e-58, 39.13% id in 460 aa; transposase 2010331..2011782 Corynebacterium diphtheriae NCTC 13129 2649009 NP_940295.1 CDS DIP1964 NC_002935.2 2012164 2013708 D Similar to Corynebacterium glutamicum ThrEonine export carrier protein ThrE TR:AAK61331 (EMBL:AF326510) (489 aa) fasta scores: E(): 7e-110, 63.45% id in 487 aa, and to Mycobacterium tuberculosis membrane protein Rv3737 TR:O69704 (EMBL:AL022121) (529 aa) fasta scores: E(): 1.6e-37, 36.1% id in 421 aa. Note: Also similar to DIP1953 (483 aa) fasta scores: E(): 3.6e-61, 44.662% identity in 459 aa overlap; amino acid export carrier protein 2012164..2013708 Corynebacterium diphtheriae NCTC 13129 2649011 NP_940296.1 CDS DIP1965 NC_002935.2 2013769 2014113 D Limited database matches. Similar to Chlamydia muridarum histone H1-like protein TC0119 SW:HCT1_CHLMU (Q9PLI1) (125 aa) fasta scores: E(): 0.19, 35.39% id in 113 aa, and to Chlamydia trachomatis histone H1-like protein CT743 SW:HCT1_CHLTR (Q02281) (125 aa) fasta scores: E(): 0.22, 35.39% id in 113 aa. CDS contains a C-terminal lysine rich region; hypothetical protein 2013769..2014113 Corynebacterium diphtheriae NCTC 13129 2649012 NP_940297.1 CDS DIP1966 NC_002935.2 2014122 2015561 D Similar to Schizosaccharomyces pombe alpha,alpha-trehalose-phosphate synthase [UDP-forming] TPS1 SW:TPS1_SCHPO (P40387) (513 aa) fasta scores: E(): 7e-55, 36.68% id in 477 aa, and to Mycobacterium tuberculosis alpha,alpha-trehalose-phosphate synthase Rv3490 TR:O06353 (EMBL:Z95390) (500 aa) fasta scores: E(): 3.1e-98, 55.18% id in 482 aa; glycosyltransferase 2014122..2015561 Corynebacterium diphtheriae NCTC 13129 2649013 NP_940298.1 CDS DIP1967 NC_002935.2 2015595 2016071 D hypothetical protein 2015595..2016071 Corynebacterium diphtheriae NCTC 13129 2649014 NP_940299.1 CDS DIP1968 NC_002935.2 2016061 2016819 D Similar to Escherichia coli trehalose-phosphatase OtsB SW:OTSB_ECOLI (P31678) (266 aa) fasta scores: E(): 1.8e-10, 30.3% id in 231 aa, and to Salmonella typhimurium trehalose-phosphatase STM1929 SW:OTSB_SALTY (Q9L894) (267 aa) fasta scores: E(): 5.1e-11, 29.78% id in 235 aa; trehalose-phosphatase 2016061..2016819 Corynebacterium diphtheriae NCTC 13129 2649015 NP_940300.1 CDS DIP1969 NC_002935.2 2016782 2017921 R Similar to Escherichia coli raffinose operon repressor RafR SW:RAFR_ECOLI (P21867) (335 aa) fasta scores: E(): 1.5e-08, 24.52% id in 367 aa, and to Mycobacterium tuberculosis hypothetical protein Rv3575c TR:P96857 (EMBL:Z92774) (359 aa) fasta scores: E(): 1.8e-50, 45.82% id in 371 aa; LacI family transcriptional regulator complement(2016782..2017921) Corynebacterium diphtheriae NCTC 13129 2649016 NP_940301.1 CDS DIP1970 NC_002935.2 2017931 2018872 R Similar to Mycobacterium tuberculosis hypothetical protein Rv3579c TR:P96861 (EMBL:Z92774) (322 aa) fasta scores: E(): 1.1e-61, 58.33% id in 312 aa, and to Streptomyces coelicolor tRNA/rRNA methyltransferase SCD8A.09 TR:Q9L0Q5 (EMBL:AL160331) (314 aa) fasta scores: E(): 2.7e-57, 55.97% id in 318 aa; SpoU rRNA methylase complement(2017931..2018872) Corynebacterium diphtheriae NCTC 13129 2649017 NP_940302.1 CDS cysS NC_002935.2 2018900 2020291 R catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase complement(2018900..2020291) Corynebacterium diphtheriae NCTC 13129 2649018 NP_940303.1 CDS ispF NC_002935.2 2020310 2020792 R catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclo diphosphate synthase complement(2020310..2020792) Corynebacterium diphtheriae NCTC 13129 2649019 NP_940304.1 CDS ispD NC_002935.2 2020785 2021519 R 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase complement(2020785..2021519) Corynebacterium diphtheriae NCTC 13129 2649020 NP_940305.1 CDS DIP1974 NC_002935.2 2021529 2022110 R N-terminal region is similar to Mycobacterium tuberculosis transcriptional factor Rv3583c TR:O53568 (EMBL:AL022075) (162 aa) fasta scores: E(): 6.8e-38, 71.69% id in 159 aa, and to Mycobacterium leprae transcription factor ML0320 TR:Q9CCW7 (EMBL:AL583918) (165 aa) fasta scores: E(): 1.2e-37, 70.44% id in 159 aa; CarD-like transcriptional factor complement(2021529..2022110) Corynebacterium diphtheriae NCTC 13129 2649021 NP_940306.1 CDS DIP1975 NC_002935.2 2022342 2022944 R hypothetical protein complement(2022342..2022944) Corynebacterium diphtheriae NCTC 13129 2649022 NP_940307.1 CDS DIP1976 NC_002935.2 2023051 2024442 R No significant database matches to the full length CDS. Internal region is similar to the C-terminal region of Streptococcus pneumoniae surface protein PspC TR:Q9KK25 (EMBL:AF154033) (763 aa) fasta scores: E(): 0.081, 25.23% id in 214 aa; hypothetical protein complement(2023051..2024442) Corynebacterium diphtheriae NCTC 13129 2649023 NP_940308.1 CDS DIP1977 NC_002935.2 2024799 2026190 D Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 2024799..2026190 Corynebacterium diphtheriae NCTC 13129 2649024 NP_940309.1 CDS DIP1978 NC_002935.2 2026218 2026934 R Similar to Mycobacterium tuberculosis hypothetical protein Rv3587c TR:O53572 (EMBL:AL022075) (264 aa) fasta scores: E(): 2.9e-10, 29.13% id in 230 aa, and to Mycobacterium leprae hypothetical membrane protein ML1918 TR:Q9CBJ2 (EMBL:AL583923) (263 aa) fasta scores: E(): 1e-08, 28.69% id in 230 aa; hypothetical protein complement(2026218..2026934) Corynebacterium diphtheriae NCTC 13129 2649025 NP_940310.1 CDS DIP1979 NC_002935.2 2027004 2027633 R Similar to Mycobacterium tuberculosis carbonic anhydrase Rv3588c TR:O53573 (EMBL:AL022075) (207 aa) fasta scores: E(): 6.4e-31, 46.31% id in 190 aa. Weakly similar to Escherichia coli carbonic anhydrase CynT SW:CYNT_ECOLI (P17582) (219 aa) fasta scores: E(): 2.8e-09, 32.22% id in 180 aa; carbonic anhydrase complement(2027004..2027633) Corynebacterium diphtheriae NCTC 13129 2649026 NP_940311.1 CDS DIP1980 NC_002935.2 2027764 2028651 D Similar to Mycobacterium leprae probable DNA glycosylase ML1920 TR:Q9CBJ0 (EMBL:AL583923) (297 aa) fasta scores: E(): 5.3e-52, 51.86% id in 295 aa. N-terminus is similar to the N-terminal region of Escherichia coli A/G-specific adenine glycosylase MutY SW:MUTY_ECOLI (P17802) (350 aa) fasta scores: E(): 2.9e-23, 40.48% id in 205 aa; DNA repair protein 2027764..2028651 Corynebacterium diphtheriae NCTC 13129 2649027 NP_940312.1 CDS DIP1981 NC_002935.2 2028648 2029901 R N-terminus is similar to the C-terminal region of Rhodobacter capsulatus hypothetical 31.0 kDa protein TR:O68029 (EMBL:AF010496) (289 aa) fasta scores: E(): 5.3e-10, 28.39% id in 243 aa, and to the full length Escherichia coli hypothetical protein YjjP SW:YJJP_ECOLI (P39402) (256 aa) fasta scores: E(): 1.3e-08, 27.16% id in 254 aa; hypothetical protein complement(2028648..2029901) Corynebacterium diphtheriae NCTC 13129 2649028 NP_940313.1 CDS DIP1982 NC_002935.2 2030032 2030202 R Poor database matches. Similar to the N-terminal region of Escherichia coli O157:H7 hypothetical protein ECS1344 TR:BAB34767 (EMBL:AE005309) (402 aa) fasta scores: E(): 9.6, 38.33% id in 60 aa. Doubtful CDS; hypothetical protein complement(2030032..2030202) Corynebacterium diphtheriae NCTC 13129 2649029 NP_940314.1 CDS clpC NC_002935.2 2030233 2032884 R Similar to Bacillus subtilis negative regulator of genetic competence ClpC SW:CLPC_BACSU (P37571) (810 aa) fasta scores: E(): 2.6e-134, 58.11% id in 826 aa, and to Mycobacterium tuberculosis probable ATP-dependent Clp protease ATP-binding subunit Rv3596c SW:CLPC_MYCTU (O06286) (848 aa) fasta scores: E(): 1.7e-186, 81.81% id in 847 aa; ATP-dependent Clp protease ATP-binding subunit complement(2030233..2032884) Corynebacterium diphtheriae NCTC 13129 2649030 NP_940315.1 CDS DIP1984 NC_002935.2 2033317 2033772 R Similar to Pasteurella multocida hypothetical protein PM0821 TR:Q9CMK3 (EMBL:AE006121) (150 aa) fasta scores: E(): 8.8e-19, 46% id in 150 aa, and to Deinococcus radiodurans conserved hypothetical protein DR1979 TR:Q9RSZ0 (EMBL:AE002036) (161 aa) fasta scores: E(): 8.6e-16, 42.66% id in 150 aa; hypothetical protein complement(2033317..2033772) Corynebacterium diphtheriae NCTC 13129 2649031 NP_940316.1 CDS DIP1985 NC_002935.2 2033808 2034446 D Poor database matches. C-terminal region is similar to Rhizobium loti hypothetical protein MLL0061 TR:Q98NN3 (EMBL:AP002994) (97 aa) fasta scores: E(): 1.7, 25% id in 96 aa. Possible alternative translational start site; hypothetical protein 2033808..2034446 Corynebacterium diphtheriae NCTC 13129 2650089 NP_940317.1 CDS DIP1986 NC_002935.2 2034499 2035347 D Similar to Homo sapiens monoglyceride lipase TR:CAC43316 (EMBL:AJ270950) (303 aa) fasta scores: E(): 1.6e-14, 28.88% id in 277 aa, and to Deinococcus radiodurans lipase DR1537 TR:Q9RU57 (EMBL:AE001997) (282 aa) fasta scores: E(): 4.2e-24, 33.69% id in 276 aa; hypothetical protein 2034499..2035347 Corynebacterium diphtheriae NCTC 13129 2650090 NP_940318.1 CDS lysS NC_002935.2 2035873 2037435 R class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase complement(2035873..2037435) Corynebacterium diphtheriae NCTC 13129 2650091 NP_940319.1 CDS DIP1988 NC_002935.2 2037819 2038799 D No significant database matches to the full length CDS. N-terminus is similar to the N-terminal region of Streptomyces coelicolor insertion element IS110 hypothetical protein SC3C8.10 SW:YIS1_STRCO (P19780) (405 aa) fasta scores: E(): 8.1e-15, 42.33% id in 137 aa, and to Shigella flexneri transposase for IS110 S0128 TR:Q9AFS5 (EMBL:AF348706) (398 aa) fasta scores: E(): 4.6e-14, 40.87% id in 137 aa; hypothetical protein 2037819..2038799 Corynebacterium diphtheriae NCTC 13129 2650092 NP_940320.1 CDS DIP1989 NC_002935.2 2038819 2039577 R Weakly similar to Streptomyces coelicolor ABC transporter integral membrane protein SCC30.14 TR:Q9L007 (EMBL:AL352972) (238 aa) fasta scores: E(): 1.9e-11, 28.91% id in 249 aa, and to Bacillus cereus hypothetical protein YvfS TR:Q9L4F5 (EMBL:AJ243712) (239 aa) fasta scores: E(): 3.1e-08, 23.79% id in 248 aa; hypothetical protein complement(2038819..2039577) Corynebacterium diphtheriae NCTC 13129 2650093 NP_940321.1 CDS DIP1990 NC_002935.2 2039574 2040497 R Similar to Rhizobium sp nodulation ATP-binding protein I NodI SW:NODI_RHIS3 (P72335) (304 aa) fasta scores: E(): 6.6e-22, 35.94% id in 306 aa, and to Streptomyces coelicolor ABC transporter ATP-binding subunit SCC30.13 TR:Q9L008 (EMBL:AL352972) (308 aa) fasta scores: E(): 2.8e-31, 39.34% id in 305 aa; ABC transporter ATP-binding protein complement(2039574..2040497) Corynebacterium diphtheriae NCTC 13129 2650094 NP_940322.1 CDS DIP1991 NC_002935.2 2040971 2041939 D Similar to Streptomyces coelicolor transmembrane protein SCK7.11c TR:Q9KIM1 (EMBL:AF230489) (312 aa) fasta scores: E(): 4.5e-47, 50.16% id in 301 aa. C-terminal region is similar to Streptococcus pneumoniae hypothetical protein SP2132 TR:AAK76190 (EMBL:AE007502) (335 aa) fasta scores: E(): 8.7e-22, 42.43% id in 304 aa; hypothetical protein 2040971..2041939 Corynebacterium diphtheriae NCTC 13129 2650095 NP_940323.1 CDS DIP1992 NC_002935.2 2042051 2043478 D C-terminal region is similar to Escherichia coli proton glutamate symport protein GltP SW:GLTP_ECOLI (P21345) (437 aa) fasta scores: E(): 2.5e-34, 29.25% id in 417 aa, and to the C-terminal region of Caulobacter crescentus sodium:dicarboxylate symporter family protein CC1104 TR:Q9A990 (EMBL:AE005788) (476 aa) fasta scores: E(): 1.4e-90, 57.93% id in 435 aa. Possible alternative translational start site; sodium/dicarboxylate symporter family protein 2042051..2043478 Corynebacterium diphtheriae NCTC 13129 2650096 NP_940324.1 CDS panC NC_002935.2 2043495 2044274 R catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase complement(2043495..2044274) Corynebacterium diphtheriae NCTC 13129 2650097 NP_940325.1 CDS DIP1994 NC_002935.2 2044287 2044910 R Poor database matches. N-terminus is similar to the C-terminal region of Pseudomonas aeruginosa malonate decarboxylase alpha subunit PA0208 TR:Q9I6T0 (EMBL:AE004459) (554 aa) fasta scores: E(): 3.7, 32.31% id in 164 aa; hypothetical protein complement(2044287..2044910) Corynebacterium diphtheriae NCTC 13129 2650098 NP_940326.1 CDS DIP1995 NC_002935.2 2044907 2045824 R Weakly similar to the N-terminal regions of Mycobacterium leprae membrane protein ML0228 TR:O69526 (EMBL:AL023093) (432 aa) fasta scores: E(): 0.025, 25.15% id in 318 aa, and to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT3709 TR:AAK48067 (EMBL:AE007170) (397 aa) fasta scores: E(): 0.071, 23.51% id in 336 aa; hypothetical protein complement(2044907..2045824) Corynebacterium diphtheriae NCTC 13129 2650099 NP_940327.1 CDS DIP1996 NC_002935.2 2045826 2046293 R Similar to Mycobacterium tuberculosis hypothetical protein Rv3605c TR:O06277 (EMBL:Z95557) (158 aa) fasta scores: E(): 1.3e-11, 39% id in 141 aa, and to Mycobacterium leprae hypothetical protein ML0227 TR:O69527 (EMBL:AL023093) (158 aa) fasta scores: E(): 5.6e-11, 36.73% id in 147 aa; hypothetical protein complement(2045826..2046293) Corynebacterium diphtheriae NCTC 13129 2650100 NP_940328.1 CDS folK NC_002935.2 2046290 2046769 R Similar to Escherichia coli 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FolK SW:HPPK_ECOLI (P26281) (158 aa) fasta scores: E(): 1.1e-11, 36.36% id in 154 aa, and to Mycobacterium tuberculosis 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Rv3606c SW:HPPK_MYCTU (O06276) (188 aa) fasta scores: E(): 6e-23, 48.93% id in 141 aa; 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase complement(2046290..2046769) Corynebacterium diphtheriae NCTC 13129 2650101 NP_940329.1 CDS DIP1998 NC_002935.2 2046779 2047144 R Similar to Corynebacterium glutamicum dihydroneopterin aldolase CGL2693 SWALL:BAC00087 (EMBL:AP005282) (130 aa) fasta scores: E(): 1.3e-30, 66.11% id in 121 aa, and to Bacillus subtilis dihydroneopterin aldolase FolB or FolA SWALL:FOLB_BACSU (SWALL:P28823) (120 aa) fasta scores: E(): 2.4e-14, 38.98% id in 118 aa; dihydroneopterin aldolase complement(2046779..2047144) Corynebacterium diphtheriae NCTC 13129 2650102 NP_940330.1 CDS DIP1999 NC_002935.2 2047150 2047986 R Similar to Mycobacterium tuberculosis dihydropteroate synthase 1 FolP1 SW:DHP1_MYCTU (O06274) (280 aa) fasta scores: E(): 4.3e-48, 53.9% id in 269 aa, and to Streptomyces coelicolor dihydropteroate synthase SCE9.05 TR:Q9X8H8 (EMBL:AL049841) (288 aa) fasta scores: E(): 6.9e-46, 53.75% id in 266 aa; dihydropteroate synthase complement(2047150..2047986) Corynebacterium diphtheriae NCTC 13129 2650103 NP_940331.1 CDS DIP2000 NC_002935.2 2048110 2048424 R Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein complement(2048110..2048424) Corynebacterium diphtheriae NCTC 13129 2650104 NP_940332.1 CDS folE NC_002935.2 2048427 2048999 R involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I complement(2048427..2048999) Corynebacterium diphtheriae NCTC 13129 2650105 NP_940333.1 CDS ftsH NC_002935.2 2049007 2051481 R Similar to Mycobacterium tuberculosis cell division protein FtsH homolog Rv3610c SW:FTSH_MYCTU (P96942) (760 aa) fasta scores: E(): 8e-126, 59.01% id in 793 aa, and to Mycobacterium leprae cell division protein FtsH TR:O69532 (EMBL:AL023093) (787 aa) fasta scores: E(): 2.6e-126, 57.03% id in 817 aa; cell division protein complement(2049007..2051481) Corynebacterium diphtheriae NCTC 13129 2650106 NP_940334.1 CDS hpt NC_002935.2 2051613 2052176 R Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively; hypoxanthine-guanine phosphoribosyltransferase complement(2051613..2052176) Corynebacterium diphtheriae NCTC 13129 2650107 NP_940335.1 CDS DIP2004 NC_002935.2 2052221 2053063 R Similar to Mycobacterium tuberculosis hypothetical 34.1 kDa protein Rv3625c or MT3727 or MTCY15C10.27 SWALL:Y0C5_MYCTU (SWALL:O06382) (323 aa) fasta scores: E(): 5.3e-28, 45.2% id in 292 aa, and to Streptomyces coelicolor hypothetical 36.7 kDa protein SCE9.13c SWALL:Q9X8I6 (EMBL:AL049841) (352 aa) fasta scores: E(): 1.6e-07, 38.72% id in 297 aa; hypothetical protein complement(2052221..2053063) Corynebacterium diphtheriae NCTC 13129 2650108 NP_940336.1 CDS DIP2005 NC_002935.2 2053092 2054372 R Similar to Mycobacterium tuberculosis hypothetical 46.8 kDa protein Rv3627c or MT3729 or MTCY15C10.25 SWALL:AAK48090 (EMBL:Z95436) (461 aa) fasta scores: E(): 5.2e-11, 37.04% id in 440 aa, and to Escherichia coli penicillin-binding protein 4 precursor DacB or B3182 SWALL:PBP4_ECOLI (SWALL:P24228) (477 aa) fasta scores: E(): 4.4e-05, 26.55% id in 433 aa; D-Ala D-Ala carboxypeptidase complement(2053092..2054372) Corynebacterium diphtheriae NCTC 13129 2650109 NP_940337.1 CDS ppa NC_002935.2 2054407 2054883 D Catalyzes the hydrolysis of pyrophosphate; inorganic pyrophosphatase 2054407..2054883 Corynebacterium diphtheriae NCTC 13129 2650110 NP_940338.1 CDS DIP2007 NC_002935.2 2055040 2055336 D Similar to Streptomyces coelicolor hypothetical 11.5 kDa protein SCH69.09c SWALL:Q9XA25 (EMBL:AL079308) (109 aa) fasta scores: E(): 4.5e-11, 43.29% id in 97 aa, and to Bacillus subtilis hypothetical 14.6 kDa protein in gcvT-spoIIIAA intergenic region YqhL SWALL:YQHL_BACSU (SWALL:P54510) (126 aa) fasta scores: E(): 4.4e-07, 39.13% id in 92 aa; hypothetical protein 2055040..2055336 Corynebacterium diphtheriae NCTC 13129 2650111 NP_940339.1 CDS DIP2008 NC_002935.2 2055410 2055871 D Similar to Caulobacter crescentus transcriptional regulator, MarR family CC3677 SWALL:Q9A289 (EMBL:AE006025) (186 aa) fasta scores: E(): 5.8e-05, 29.75% id in 121 aa, and to Escherichia coli multiple antibiotic resistance protein MarR or SoxQ or CfxB or InaR or B1530 SWALL:MARR_ECOLI (SWALL:P27245) (144 aa) fasta scores: E(): 0.00044, 30.35% id in 112 aa; MarR family transcriptional regulator 2055410..2055871 Corynebacterium diphtheriae NCTC 13129 2650112 NP_940340.1 CDS DIP2009 NC_002935.2 2055872 2059675 D N-terminal region similar to C-terminal region of Streptomyces lavendulae peptide synthetase SWALL:AAK81825 (EMBL:AF386507) (1531 aa) fasta scores: E(): 1.3e-38, 34.02% id in 814 aa, similar in its full length to Agrobacterium tumefaciens StrC58 AGR_l_3476p SWALL:AAK90311 (EMBL:AE008376) (1344 aa) fasta scores: E(): 6.2e-36, 32.96% id in 1338 aa, and N-terminal region similar to the full length of Amycolatopsis orientalis PCZA361.18 SWALL:O52803 (EMBL:AJ223998) (580 aa) fasta scores: E(): 1.3e-33, 38.2% id in 589 aa. C-terminal region presents low similarity database matches to Rhizobium loti (Mesorhizobium loti) peptide synthetase SWALL:Q98JF4 (1325 aa) blastp scores: E(): 3e-13, Identities = 77/327 (23%), Positives = 127/327 (38%); peptide synthase 2055872..2059675 Corynebacterium diphtheriae NCTC 13129 2650113 NP_940341.1 CDS DIP2010 NC_002935.2 2059672 2065290 R Similar to Actinomyces viscosus usher-like protein precursor TR:Q9AJ93 (EMBL:AF106034) (1411 aa) fasta scores: E(): 0.034, 22.657% id in 843 aa, and to Actinomyces naeslundii fimbrial associated protein TR:O05995 (EMBL:U85708) (375 aa) fasta scores: E(): 0.14, 25.131% id in 191 aa. Note: Contains a potential sortase anchor site (LPLTG) upstream of the C-terminal region transmembrane domain; surface-anchored membrane protein complement(2059672..2065290) Corynebacterium diphtheriae NCTC 13129 2650114 NP_940342.1 CDS DIP2011 NC_002935.2 2065294 2065911 R No significant database matches. Note: Contains a potential sortase anchor site (LAFTG) upstream of the C-terminal region transmembrane domain; surface anchored protein complement(2065294..2065911) Corynebacterium diphtheriae NCTC 13129 2650115 NP_940343.1 CDS DIP2012 NC_002935.2 2065901 2066770 R Similar to Actinomyces viscosus sortase-like protein SWALL:Q9AJ92 (EMBL:AF106034) (387 aa) fasta scores: E(): 2.7e-39, 43.47% id in 276 aa, and to Bifidobacterium longum NCC2705 sortase-like protein BL0676 SWALL:AAN24497 (EMBL:AE014690) (328 aa) fasta scores: E(): 3.7e-28, 36.94% id in 268 aa, and to Streptococcus pneumoniae sortase, SP0466 SWALL:AAK74626 (EMBL:AE007358) (279 aa) fasta scores: E(): 3e-21, 31.78% id in 258 aa; fimbrial associated sortase-like protein complement(2065901..2066770) Corynebacterium diphtheriae NCTC 13129 2650116 NP_940344.1 CDS DIP2013 NC_002935.2 2066771 2068348 R Similar to Actinomyces naeslundii fimbrial subunit type 2 precursor SW:FM2_ACTNA (P12616) (534 aa) fasta scores: E(): 4.4e-20, 28.827% id in 503 aa, and to Actinomyces naeslundii type-1 fimbrial major subunit precursor FimP TR:Q9X4D8 (EMBL:AF107019) (533 aa) fasta scores: E(): 8.5e-15, 27.432% id in 514 aa. Note: Contains a potential sortase anchor site (LPLTG) upstream of the C-terminal region transmembrane domain; surface-anchored fimbrial subunit complement(2066771..2068348) Corynebacterium diphtheriae NCTC 13129 2650117 NP_940345.1 CDS DIP2014 NC_002935.2 2068581 2069309 D membrane-anchored protein 2068581..2069309 Corynebacterium diphtheriae NCTC 13129 2650118 NP_940346.1 CDS DIP2015 NC_002935.2 2069482 2070753 D Similar to Streptomyces coelicolor secreted protein SC10G8.24c TR:Q9L181 (EMBL:AL158057) (445 aa) fasta scores: E(): 7.7e-31, 35.363% id in 427 aa, and to Saccharopolyspora spinosa SpnM TR:Q9ALN4 (EMBL:AY007564) (320 aa) fasta scores: E(): 2.2e-23, 36.111% id in 288 aa, and to Candida albicans secretory lipase 5 Lip5 TR:Q9P8W0 (EMBL:AF191318) (463 aa) fasta scores: E(): 2.1e-17, 24.877% id in 406 aa; exported lipase 2069482..2070753 Corynebacterium diphtheriae NCTC 13129 2650119 NP_940347.1 CDS DIP2016 NC_002935.2 2070770 2071666 R Similar to Pseudomonas aeruginosa hypothetical protein PA0141 SWALL:Q9I6Z1 (EMBL:AE004452) (298 aa) fasta scores: E(): 1.2e-69, 62.06% id in 261 aa, and to Rhizobium loti MLL5641 protein SWALL:Q98BC2 (EMBL:AP003007) (302 aa) fasta scores: E(): 9.2e-57, 49.63% id in 274 aa; hypothetical protein complement(2070770..2071666) Corynebacterium diphtheriae NCTC 13129 2650120 NP_940348.1 CDS DIP2017 NC_002935.2 2071758 2073029 R Similar to Mycobacterium leprae hypothetical protein ML2321 SWALL:Q9CB79 (EMBL:AL583925) (336 aa) fasta scores: E(): 5.7e-12, 29.15% id in 343 aa; hypothetical protein complement(2071758..2073029) Corynebacterium diphtheriae NCTC 13129 2650121 NP_940349.1 CDS DIP2018 NC_002935.2 2073112 2073252 R Doubtful CDS. No significant database matches; hypothetical protein complement(2073112..2073252) Corynebacterium diphtheriae NCTC 13129 2650122 NP_940350.1 CDS DIP2019 NC_002935.2 2073342 2073647 R Similar to Rhizobium loti transposase MLR9644 SWALL:Q98P21 (EMBL:AP003017) (103 aa) fasta scores: E(): 7, 30.58% id in 85 aa; transposase complement(2073342..2073647) Corynebacterium diphtheriae NCTC 13129 2650123 NP_940351.1 CDS groEL NC_002935.2 2073868 2075508 R 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; molecular chaperone GroEL complement(2073868..2075508) Corynebacterium diphtheriae NCTC 13129 2650124 NP_940352.1 CDS DIP2021 NC_002935.2 2075866 2076036 R Similar to Corynebacterium jeikeium YkwC SWALL:AAK94053 (EMBL:AF401314) (102 aa) fasta scores: E(): 2.3e-06, 64.28% id in 42 aa; hypothetical protein complement(2075866..2076036) Corynebacterium diphtheriae NCTC 13129 2650125 NP_940353.1 CDS DIP2022 NC_002935.2 2076283 2076546 R hypothetical protein complement(2076283..2076546) Corynebacterium diphtheriae NCTC 13129 2650126 NP_940354.1 CDS DIP2023 NC_002935.2 2076614 2077324 D Similar to the central domain of Arthrobacter keyseri hypothetical 45.9 kDa protein TnpX SWALL:Q9AGM1 (EMBL:AF331043) (421 aa) fasta scores: E(): 2.1e-12, 35.44% id in 237 aa; hypothetical protein 2076614..2077324 Corynebacterium diphtheriae NCTC 13129 2650127 NP_940355.1 CDS DIP2024 NC_002935.2 2077317 2077544 R hypothetical protein complement(2077317..2077544) Corynebacterium diphtheriae NCTC 13129 2650128 NP_940356.1 CDS DIP2025 NC_002935.2 2077594 2078898 R Similar to Pseudomonas aeruginosa hypothetical protein PA4583 SWALL:Q9HVK1 (EMBL:AE004872) (404 aa) fasta scores: E(): 7.5e-64, 45.92% id in 405 aa, and to Escherichia coli protein RtcB or B3421 SWALL:RTCB_ECOLI (SWALL:P46850) (408 aa) fasta scores: E(): 6e-45, 46.75% id in 385 aa; hypothetical protein complement(2077594..2078898) Corynebacterium diphtheriae NCTC 13129 2650129 NP_940357.1 CDS DIP2030 NC_002935.2 2080479 2081561 R Similar to Xylella fastidiosa NAD(P)H-dependent 2-cyclohexen-1-one reductase XF1732 SWALL:Q9PCP6 (EMBL:AE003996) (368 aa) fasta scores: E(): 1.3e-62, 50.56% id in 356 aa, and to Pseudomonas syringae NAD(P)H-dependent 2-cyclohexen-1-one reductase Ncr SWALL:Q9Z3T1 (EMBL:AF093246) (360 aa) fasta scores: E(): 4e-45, 40.54% id in 365 aa; NAD(P)H-dependent reductase complement(2080479..2081561) Corynebacterium diphtheriae NCTC 13129 2650131 NP_940358.1 CDS uvrA2 NC_002935.2 2081863 2084454 D Similar to Pseudomonas lemoignei excinuclease ABC subunit A UvrA SWALL:UVRA_PSELE (SWALL:P52087) (689 aa) fasta scores: E(): 1.1e-73, 60.02% id in 703 aa, and to Micrococcus luteus excinuclease ABC subunit A UvrA SWALL:UVRA_MICLU (SWALL:P13567) (992 aa) fasta scores: E(): 8.7e-50, 38.63% id in 1012 aa, and to Streptomyces coelicolor excinuclease ABC subunit A Uvra or SCC54.18c SWALL:UVRA_STRCO (SWALL:Q9Z507) (1014 aa) fasta scores: E(): 2.8e-49, 39.67% id in 993 aa; excinuclease ABC subunit A 2081863..2084454 Corynebacterium diphtheriae NCTC 13129 2650132 NP_940359.1 CDS DIP2032 NC_002935.2 2084696 2085232 D Similar to Pseudomonas aeruginosa probable protease PA4171 SWALL:Q9HWL0 (EMBL:AE004833) (187 aa) fasta scores: E(): 3.2e-25, 50.28% id in 175 aa, and to Pyrococcus furiosus protease I PfpI or PF1719 SWALL:PFPI_PYRFU (SWALL:Q51732) (166 aa) fasta scores: E(): 1.8e-19, 40.58% id in 170 aa; protease 2084696..2085232 Corynebacterium diphtheriae NCTC 13129 2650133 NP_940360.1 CDS DIP2033 NC_002935.2 2085350 2085481 R Similar partially to the C-terminal region of Saccharopolyspora sp transposase SapX SWALL:O52713 (EMBL:AF045021) (103 aa) fasta scores: E(): 1.3e-06, 58.53% id in 41 aa, and to Mycobacterium tuberculosis insertion element IS986 hypothetical 6.6 kDa protein SWALL:YIA2_MYCTU (SWALL:P19772) (59 aa) fasta scores: E(): 9.5e-05, 60% id in 35 aa; transposase complement(2085350..2085481) Corynebacterium diphtheriae NCTC 13129 2650134 NP_940361.1 CDS DIP2036 NC_002935.2 2086286 2086948 D hypothetical protein 2086286..2086948 Corynebacterium diphtheriae NCTC 13129 2650136 NP_940362.1 CDS DIP2037 NC_002935.2 2087440 2088801 D Similar to Streptomyces coelicolor peptidase SCG22.20 SWALL:Q9K425 (EMBL:AL359779) (451 aa) fasta scores: E(): 5.7e-70, 44.19% id in 448 aa, and to Mycobacterium leprae hypothetical 46.6 kDa protein ML1193 or MLCB458.08 SWALL:Q9X7E4 (EMBL:AL049478) (442 aa) fasta scores: E(): 1.1e-52, 37.41% id in 441 aa; hypothetical protein 2087440..2088801 Corynebacterium diphtheriae NCTC 13129 2650137 NP_940363.1 CDS DIP2038 NC_002935.2 2088814 2089029 D Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 2088814..2089029 Corynebacterium diphtheriae NCTC 13129 2650138 NP_940364.1 CDS DIP2039 NC_002935.2 2089037 2089327 D hypothetical protein 2089037..2089327 Corynebacterium diphtheriae NCTC 13129 2650139 NP_940365.1 CDS DIP2040 NC_002935.2 2089327 2090487 D Similar to Mycobacterium leprae probable conserved membrane protein ML1504 SWALL:Q9CBX0 (EMBL:AL583922) (430 aa) fasta scores: E(): 1.8e-10, 31.8% id in 349 aa, and to Mycobacterium tuberculosis hypothetical 47.1 kDa protein Rv1159 or MT1195 or MTCI65.26 SWALL:O06557 (EMBL:Z95584) (431 aa) fasta scores: E(): 4.3e-10, 31.66% id in 360 aa; hypothetical protein 2089327..2090487 Corynebacterium diphtheriae NCTC 13129 2650140 NP_940366.1 CDS DIP2042 NC_002935.2 2090430 2091509 R ATP-dependent carboxylate-amine ligase; carboxylate-amine ligase complement(2090430..2091509) Corynebacterium diphtheriae NCTC 13129 2650141 NP_940367.1 CDS DIP2043 NC_002935.2 2091506 2092039 R hypothetical protein complement(2091506..2092039) Corynebacterium diphtheriae NCTC 13129 2650142 NP_940368.1 CDS DIP2044 NC_002935.2 2092042 2092245 R Similar to Streptomyces coelicolor hypothetical 9.6 kDa protein SCD95A.20 SWALL:Q9KXV4 (EMBL:AL357432) (84 aa) fasta scores: E(): 1e-08, 54.09% id in 61 aa, and to Mycobacterium tuberculosis hypothetical 11.7 kDa protein Rv0430 or MT0445 or MTCY22G10.27 SWALL:P96276 (EMBL:Z84724) (102 aa) fasta scores: E(): 2.2e-07, 48.38% id in 62 aa; hypothetical protein complement(2092042..2092245) Corynebacterium diphtheriae NCTC 13129 2650143 NP_940369.1 CDS def NC_002935.2 2092244 2092807 D cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 2092244..2092807 Corynebacterium diphtheriae NCTC 13129 2650144 NP_940370.1 CDS DIP2046 NC_002935.2 2092824 2093711 D Similar to Mycobacterium tuberculosis hypothetical 32.6 kDa protein Rv0428c or MT0443 or MTCY22G10.25c SWALL:P96274 (EMBL:Z84724) (302 aa) fasta scores: E(): 2.7e-22, 34.53% id in 304 aa, and to Caulobacter crescentus acetyltransferase, GNAT family CC2209 SWALL:Q9A685 (EMBL:AE005892) (207 aa) fasta scores: E(): 2.4e-06, 30.76% id in 208 aa; hypothetical protein 2092824..2093711 Corynebacterium diphtheriae NCTC 13129 2650145 NP_940371.1 CDS DIP2047 NC_002935.2 2093716 2094423 D Similar to Streptomyces coelicolor exonuclease SC3A7.09 SWALL:O86610 (EMBL:AL031155) (259 aa) fasta scores: E(): 4.4e-32, 51.93% id in 258 aa, and to Mycobacterium tuberculosis CDC1551 exodeoxyribonuclease III MT0442 SWALL:AAK44665 (EMBL:AE006947) (291 aa) fasta scores: E(): 1.2e-25, 54.16% id in 264 aa; exonuclease 2093716..2094423 Corynebacterium diphtheriae NCTC 13129 2650146 NP_940372.1 CDS DIP2048 NC_002935.2 2094420 2095853 D Similar to Xylella fastidiosa cardiolipin synthase XF1209 SWALL:Q9PE19 (EMBL:AE003954) (467 aa) fasta scores: E(): 3.2e-52, 35.02% id in 474 aa, and to Bacillus firmus cardiolipin synthetase Cls SWALL:CLS_BACFI (SWALL:O66043) (503 aa) fasta scores: E(): 3.4e-41, 30.56% id in 494 aa, and to Escherichia coli cardiolipin synthetase Cls or Nov or B1249 SWALL:CLS_ECOLI (SWALL:P31071) (486 aa) fasta scores: E(): 2.6e-37, 27.18% id in 493 aa; cardiolipin synthase 2094420..2095853 Corynebacterium diphtheriae NCTC 13129 2650147 NP_940373.1 CDS DIP2049 NC_002935.2 2096446 2097183 R Low similarity to Streptomyces coelicolor ABC transporter integral membrane protein SCE8.16c SWALL:Q9Z4W1 (EMBL:AL035654) (264 aa) fasta scores: E(): 1.7e-09, 26.37% id in 254 aa; ABC transporter complement(2096446..2097183) Corynebacterium diphtheriae NCTC 13129 2650148 NP_940374.1 CDS DIP2050 NC_002935.2 2097167 2098096 R Similar to Streptomyces coelicolor ABC transporter ATP-binding subunit 2SC6G5.39c SWALL:Q9K4B6 (EMBL:AL359152) (346 aa) fasta scores: E(): 9.3e-56, 60% id in 305 aa, and to Bacillus sphaericus CDD4-like protein SWALL:Q9Z5R0 (EMBL:AJ224479) (311 aa) fasta scores: E(): 7.9e-29, 37.45% id in 299 aa; ABC transporter ATP-binding protein complement(2097167..2098096) Corynebacterium diphtheriae NCTC 13129 2650149 NP_940375.1 CDS DIP2051 NC_002935.2 2098098 2099354 D Similar to Mycobacterium leprae membrane protein MLCB1450.21c SWALL:Q9ZBL6 (EMBL:AL035159) (403 aa) fasta scores: E(): 3.4e-22, 32.51% id in 406 aa, and to Mycobacterium tuberculosis hypothetical 47.1 kDa protein Rv0412c or MT0425 or MTCY22G10.08c SWALL:AAK44649 (EMBL:Z84724) (439 aa) fasta scores: E(): 3.1e-21, 33.09% id in 414 aa; hypothetical protein 2098098..2099354 Corynebacterium diphtheriae NCTC 13129 2650150 NP_940376.1 CDS DIP2052 NC_002935.2 2099351 2100298 D Similar to Mycobacterium tuberculosis CDC1551 amino acid ABC transporter, amino acid-binding protein MT0424 SWALL:AAK44648 (EMBL:AE006946) (328 aa) fasta scores: E(): 1.5e-33, 41.84% id in 325 aa, and to Bacillus stearothermophilus glutamine-binding protein precursor GlnH SWALL:GLNH_BACST (SWALL:P27676) (262 aa) fasta scores: E(): 5.3e-19, 31.25% id in 240 aa; ABC transporter 2099351..2100298 Corynebacterium diphtheriae NCTC 13129 2650151 NP_940377.1 CDS DIP2053 NC_002935.2 2100295 2102457 D Similar to Mycobacterium tuberculosis probable serine/threonine-protein kinase PknG or Rv0410c or MT0423 or MTCY22G10.06c SWALL:PKNG_MYCTU (SWALL:P96256) (750 aa) fasta scores: E(): 2.8e-52, 44.97% id in 656 aa, and to Mycobacterium tuberculosis probable serine/threonine-protein kinase PknL or Rv2176 or MT2232 or MTV021.09 SWALL:PKNL_MYCTU (SWALL:O53510) (399 aa) fasta scores: E(): 4e-06, 28.61% id in 318 aa; protein kinase 2100295..2102457 Corynebacterium diphtheriae NCTC 13129 2650152 NP_940378.1 CDS ackA NC_002935.2 2102477 2103676 R AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase complement(2102477..2103676) Corynebacterium diphtheriae NCTC 13129 2650153 NP_940379.1 CDS eutD NC_002935.2 2103677 2105128 R in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase complement(2103677..2105128) Corynebacterium diphtheriae NCTC 13129 2650154 NP_940380.1 CDS DIP2056 NC_002935.2 2105308 2106666 D Similar to Streptomyces coelicolor ferredoxin/ferredoxin-NADP reductase SCF15.02 SWALL:Q9RK35 (EMBL:AL132856) (454 aa) fasta scores: E(): 4e-107, 59.95% id in 452 aa, and to Rattus norvegicus NADPH:adrenodoxin oxidoreductase, mitochondrial precursor FdxR SWALL:ADRO_RAT (SWALL:P56522) (494 aa) fasta scores: E(): 1.3e-42, 36.02% id in 458 aa, and to Mycobacterium tuberculosis probable ferredoxin/ferredoxin--NADP reductase FprB or Rv0886 or MT0909 or MTCY31.14 SWALL:FPRB_MYCTU (SWALL:Q10547) (575 aa) fasta scores: E(): 2.1e-33, 35.98% id in 453 aa; ferredoxin/ferredoxin-NADP reductase 2105308..2106666 Corynebacterium diphtheriae NCTC 13129 2650155 NP_940381.1 CDS DIP2057 NC_002935.2 2106678 2107574 R Similar to although shorter in its N-terminal region than Pasteurella haemolytica probable phosphoribosylglycinamide formyltransferase 2 PurT or Mpa1 SWALL:PURT_PASHA (SWALL:P46927) (392 aa) fasta scores: E(): 1e-12, 32.24% id in 276 aa, than Bacillus subtilis phosphoribosylglycinamide formyltransferase 2 PurT SWALL:PURT_BACSU (SWALL:P39771) (384 aa) fasta scores: E(): 3.8e-12, 35.81% id in 282 aa, and than Escherichia coli phosphoribosylglycinamide formyltransferase 2 PurT or B1849 SWALL:PURT_ECOLI (SWALL:P33221) (391 aa) fasta scores: E(): 1.2e-09, 29.82% id in 285 aa; phosphoribosylglycinamide formyltransferase complement(2106678..2107574) Corynebacterium diphtheriae NCTC 13129 2650156 NP_940382.1 CDS DIP2058 NC_002935.2 2107606 2108106 D Similar to Streptomyces coelicolor purine phosphoribosyltransferase SCH35.47 SWALL:Q9X8V9 (EMBL:AL078610) (165 aa) fasta scores: E(): 1.1e-27, 52.25% id in 155 aa, and to Aeropyrum pernix 272aa long hypothetical hypoxanthine phosphoribosyltransferase APE2071 SWALL:Q9YA68 (EMBL:AP000063) (272 aa) fasta scores: E(): 3.8e-16, 36.47% id in 159 aa; purine phosphoribosyltransferase 2107606..2108106 Corynebacterium diphtheriae NCTC 13129 2650157 NP_940383.1 CDS DIP2059 NC_002935.2 2108231 2109025 D No significant database matches. Note: Also similar to DIP0167 (259 aa) E(): 4.6e-41; 44.747% identity in 257 aa overlap; hypothetical protein 2108231..2109025 Corynebacterium diphtheriae NCTC 13129 2650158 NP_940384.1 CDS DIP2060 NC_002935.2 2109022 2110452 R Low similarity to Campylobacter jejuni membrane protein CjaE SWALL:Q9RM70 (EMBL:AJ249744) (505 aa) fasta scores: E(): 3.1e-24, 28.45% id in 471 aa; hypothetical protein complement(2109022..2110452) Corynebacterium diphtheriae NCTC 13129 2650159 NP_940385.1 CDS DIP2061 NC_002935.2 2110453 2110620 R Similar to Helicobacter pylori hypothetical 6.1 kDa protein HP0594 SWALL:O25316 (EMBL:AE000573) (54 aa) fasta scores: E(): 0.026, 32.72% id in 55 aa, and to Campylobacter jejuni small hydrophobic protein CJ0018c SWALL:Q9PJ93 (EMBL:AL139074) (55 aa) fasta scores: E(): 0.046, 35.71% id in 56 aa. Note: Highly hydrophobic; hypothetical protein complement(2110453..2110620) Corynebacterium diphtheriae NCTC 13129 2650160 NP_940386.1 CDS DIP2062 NC_002935.2 2111093 2112964 R Low similarity to Streptococcus agalactiae BPS protein precursor Sar5 TR:Q9XAS7 (EMBL:AJ133114) (979 aa) fasta scores: E(): 7.1e-12, 32.35% id in 442 aa, and to Staphylococcus epidermidis cell-surface adhesin SdrF TR:Q9KI14 (EMBL:AF245041) (1733 aa) fasta scores: E(): 0.015, 24.86% id in 539 aa. Note: Contains a potential sortase anchor site (LAATG) upstream of the C-terminal region transmembrane domain; surface anchored protein complement(2111093..2112964) Corynebacterium diphtheriae NCTC 13129 2650161 NP_940387.1 CDS purA NC_002935.2 2113380 2114669 R catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase complement(2113380..2114669) Corynebacterium diphtheriae NCTC 13129 2650162 NP_940388.1 CDS DIP2064 NC_002935.2 2114764 2114973 D Similar to part of several beta-ketoacyl-ACP synthases e.g. Streptomyces coelicolor actinorhodin polyketide beta-ketoacyl synthase 1 SW:KASA_STRCO (Q02059) (424 aa) fasta scores: E(): 2.1, 31.343% id in 67 aa, and to Arabidopsis thaliana 3-oxoacyl-[acyl-carrier-protein] synthase I, chloroplast precursor Kas1 SW:FABB_ARATH (P52410) (473 aa) fasta scores: E(): 5.8, 27.273% id in 77 aa; beta-ketoacyl-ACP synthase gene remnant 2114764..2114973 Corynebacterium diphtheriae NCTC 13129 2650163 NP_940389.1 CDS DIP2065 NC_002935.2 2115398 2115535 D Similar to part of several hyrolases e.g. Rhodococcus globerulus 2-hydroxy-6-ketonona-2,4-dienoate hydrolase HppC TR:O05145 (EMBL:U89712) (288 aa) fasta scores: E(): 3.9e-15, 80.000% id in 45 aa, and to Pseudomonas putida 2-hydroxymuconic semialdehyde hydrolase XylF SW:XYLF_PSEPU (P23106) (281 aa) fasta scores: E(): 0.00093, 41.667% id in 36 aa; hydrolase gene remnant 2115398..2115535 Corynebacterium diphtheriae NCTC 13129 2650164 NP_940390.1 CDS DIP2066 NC_002935.2 2115840 2119082 D Some similarity to Actinomyces naeslundii fimbrial associated protein TR:O05995 (EMBL:U85708) (375 aa) fasta scores: E(): 0.0012, 28.803% id in 309 aa. Note: Contains a potential sortase anchor site (LPKTG) upstream of the C-terminal region transmembrane domain; surface-anchored fimbrial associated protein 2115840..2119082 Corynebacterium diphtheriae NCTC 13129 2650165 NP_940391.1 CDS DIP2067 NC_002935.2 2119377 2120108 D Similar to Mycobacterium leprae hypothetical 25.3 kDa protein ML0281 or MLCB4.24 SWALL:O69596 (EMBL:AL023514) (229 aa) fasta scores: E(): 6.1e-08, 36.63% id in 202 aa; hypothetical protein 2119377..2120108 Corynebacterium diphtheriae NCTC 13129 2650166 NP_940392.1 CDS DIP2068 NC_002935.2 2120105 2121232 R Similar to Corynebacterium glutamicum hypothetical protein in fda 3'region SWALL:YFDA_CORGL (SWALL:Q99340) (359 aa) fasta scores: E(): 4.8e-63, 51.61% id in 341 aa, and to Mycobacterium tuberculosis hypothetical 36.8 kDa protein Rv2571c or MT2647 or MTCY227.30 SWALL:YP71_MYCTU (SWALL:Q50650) (355 aa) fasta scores: E(): 1.1e-12, 25.07% id in 331 aa. Note: Also similar to DIP2070 (393 aa) E(): 8.6e-66; 52.174% identity in 368 aa overlap; hypothetical protein complement(2120105..2121232) Corynebacterium diphtheriae NCTC 13129 2650167 NP_940393.1 CDS DIP2069 NC_002935.2 2121346 2122479 D hypothetical protein 2121346..2122479 Corynebacterium diphtheriae NCTC 13129 2650168 NP_940394.1 CDS DIP2070 NC_002935.2 2122571 2123752 R Similar to Corynebacterium glutamicum hypothetical protein in fda 3'region SWALL:YFDA_CORGL (SWALL:Q99340) (359 aa) fasta scores: E(): 8.6e-62, 48.97% id in 341 aa, and to Mycobacterium tuberculosis hypothetical 36.8 kDa protein Rv2571c or MT2647 or MTCY227.30 SWALL:YP71_MYCTU (SWALL:Q50650) (355 aa) fasta scores: E(): 3.6e-12, 28.2% id in 234 aa. Note: Also similar to DIP2068 (375 aa) E(): 8.4e-62; 52.174% identity in 368 aa overlap; hypothetical protein complement(2122571..2123752) Corynebacterium diphtheriae NCTC 13129 2650169 NP_940395.1 CDS DIP2071 NC_002935.2 2124164 2125075 D hypothetical protein 2124164..2125075 Corynebacterium diphtheriae NCTC 13129 2650170 NP_940396.1 CDS DIP2072 NC_002935.2 2125361 2126473 D hypothetical protein 2125361..2126473 Corynebacterium diphtheriae NCTC 13129 2650171 NP_940397.1 CDS DIP2073 NC_002935.2 2126517 2127308 D hypothetical protein 2126517..2127308 Corynebacterium diphtheriae NCTC 13129 2650172 NP_940398.1 CDS DIP2074 NC_002935.2 2127573 2127881 D Similar to Escherichia coli Hp2 or InsA SWALL:O87507 (EMBL:AF081284) (100 aa) fasta scores: E(): 8.6e-07, 31.95% id in 97 aa, and to Shigella flexneri TnpJ or S0170 or S0109 SWALL:Q9XCG9 (EMBL:AF141323) (100 aa) fasta scores: E(): 8.6e-07, 31.95% id in 97 aa, and to Shigella dysenteriae InsA SWALL:Q9LA21 (EMBL:AF153317) (100 aa) fasta scores: E(): 2.1e-06, 31.95% id in 97 aa; tranposase 2127573..2127881 Corynebacterium diphtheriae NCTC 13129 2650173 NP_940399.1 CDS DIP2075 NC_002935.2 2127929 2128273 R hypothetical protein complement(2127929..2128273) Corynebacterium diphtheriae NCTC 13129 2650174 NP_940400.1 CDS DIP2076 NC_002935.2 2128362 2128724 D hypothetical protein 2128362..2128724 Corynebacterium diphtheriae NCTC 13129 2650175 NP_940401.1 CDS DIP2077 NC_002935.2 2128744 2128917 D hypothetical protein 2128744..2128917 Corynebacterium diphtheriae NCTC 13129 2650176 NP_940402.1 CDS DIP2077A NC_002935.2 2128919 2129182 R hypothetical protein complement(2128919..2129182) Corynebacterium diphtheriae NCTC 13129 2650177 NP_940403.1 CDS DIP2078 NC_002935.2 2129194 2130531 R member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function; inner membrane permease YgbN complement(2129194..2130531) Corynebacterium diphtheriae NCTC 13129 2650178 NP_940404.1 CDS DIP2079 NC_002935.2 2130534 2131430 R Similar to many oxidoreductases e.g. Rhizobium meliloti oxidoreductase R01702 or SMC00274 SWALL:CAC46281 (EMBL:AL591788) (295 aa) fasta scores: E(): 7.6e-30, 41.4% id in 285 aa, and to Escherichia coli hypothetical oxidoreductase YgbJ or B2736 SWALL:YGBJ_ECOLI (SWALL:Q46888) (302 aa) fasta scores: E(): 2e-26, 36.08% id in 291 aa; oxidoreductase complement(2130534..2131430) Corynebacterium diphtheriae NCTC 13129 2650179 NP_940405.1 CDS DIP2080 NC_002935.2 2131499 2132950 R Similar to Synechocystis sp hypothetical 48.5 kDa protein SLR1342 SWALL:P74079 (EMBL:D90912) (445 aa) fasta scores: E(): 2.4e-39, 34.19% id in 462 aa; hypothetical protein complement(2131499..2132950) Corynebacterium diphtheriae NCTC 13129 2649551 NP_940406.1 CDS DIP2081 NC_002935.2 2133153 2133851 R Similar to Escherichia coli O157:H7 transcriptional regulator LldR or Z5031 or ECS4482 SWALL:BAB37905 (EMBL:AE005588) (258 aa) fasta scores: E(): 1.9e-14, 33.48% id in 224 aa, and to Pseudomonas aeruginosa transcriptional regulator GlcC or PA5356 SWALL:Q9HTK2 (EMBL:AE004947) (251 aa) fasta scores: E(): 1e-13, 32.36% id in 241 aa; transcriptional regulator complement(2133153..2133851) Corynebacterium diphtheriae NCTC 13129 2649552 NP_940407.1 CDS DIP2083 NC_002935.2 2135858 2137066 D Similar to Streptomyces coelicolor insertion element IS110 hypothetical 43.6 kDa protein SC3C8.10 and SCC57A.30c and SCG2.18 and SC5E9.30 SWALL:YIS1_STRCO (SWALL:P19780) (405 aa) fasta scores: E(): 1.6e-52, 40.65% id in 396 aa, and to Shigella flexneri transposase for IS110 s0128 SWALL:Q9AFS5 (EMBL:AF348706) (398 aa) fasta scores: E(): 1.5e-47, 42.44% id in 384 aa; transposase for insertion element 2135858..2137066 Corynebacterium diphtheriae NCTC 13129 2649554 NP_940408.1 CDS DIP2085 NC_002935.2 2138047 2138529 D Similar to Streptococcus pneumoniae hypothetical 20.7 kDa protein SWALL:Q9KK22 (EMBL:AF154034) (171 aa) fasta scores: E(): 3.2e-09, 33.54% id in 155 aa, and to Escherichia coli insertion element IS1397 hypothetical 20.1 kDa protein SWALL:YI9A_ECOLI (SWALL:Q47309) (173 aa) fasta scores: E(): 0.0075, 33.62% id in 113 aa; insertion element 2138047..2138529 Corynebacterium diphtheriae NCTC 13129 2649556 NP_940409.1 CDS DIP2093 NC_002935.2 2141760 2144615 D Low similarity to Staphylococcus aureus (strain N315) Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein SdrC or SA0519 or SAV0561 SWALL:BAB56723 (EMBL:AP003131) (953 aa) fasta scores: E(): 4.5e-06, 28.57% id in 448 aa, and to Staphylococcus aureus SdrC protein SWALL:O86487 (EMBL:AJ005645) (947 aa) fasta scores: E(): 1.6e-05, 25% id in 804 aa. Note: There is no similarity to the C-terminal SD rich region of the database hits and contains a potential sortase anchor site (LAATG) upstream of the C-terminal region transmembrane domain; Sdr family related adhesin 2141760..2144615 Corynebacterium diphtheriae NCTC 13129 2649560 NP_940410.1 CDS fba NC_002935.2 2144833 2145867 R catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase complement(2144833..2145867) Corynebacterium diphtheriae NCTC 13129 2649561 NP_940411.1 CDS DIP2095 NC_002935.2 2145986 2147113 R Similar to Mycobacterium tuberculosis CDC1551 fructose-bisphosphate aldolase MT0381 SWALL:AAK44602 (EMBL:AE006943) (376 aa) fasta scores: E(): 7.2e-55, 43.61% id in 376 aa, and to Corynebacterium glutamicum hypothetical protein in fda 5' region SWALL:Q99336 (EMBL:X17313) (304 aa) fasta scores: E(): 1.6e-37, 60.55% id in 289 aa; hypothetical protein complement(2145986..2147113) Corynebacterium diphtheriae NCTC 13129 2649562 NP_940412.1 CDS DIP2096 NC_002935.2 2147125 2147643 R Similar to although shoter in its N-terminal region than Mycobacterium tuberculosis CDC1551 SpoU rRNA methylase MT0393 SWALL:AAK44615 (EMBL:AE006944) (183 aa) fasta scores: E(): 6.2e-51, 74.41% id in 172 aa, and to Escherichia coli tRNA TrmH or SpoU or B3651 or Z5077 or ECS4526 SWALL:TRMH_ECOLI (SWALL:P19396) (229 aa) fasta scores: E(): 4.6e-07, 28.94% id in 152 aa; RNA methylase complement(2147125..2147643) Corynebacterium diphtheriae NCTC 13129 2649563 NP_940413.1 CDS pyrE NC_002935.2 2147786 2148319 R involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase complement(2147786..2148319) Corynebacterium diphtheriae NCTC 13129 2649564 NP_940414.1 CDS DIP2098 NC_002935.2 2148375 2149289 R hypothetical protein complement(2148375..2149289) Corynebacterium diphtheriae NCTC 13129 2649565 NP_940415.1 CDS DIP2099 NC_002935.2 2149289 2150113 R Similar to Streptomyces coelicolor thiosulfate sulfurtransferase SC9B10.21 SWALL:O50528 (EMBL:AL009204) (283 aa) fasta scores: E(): 1.8e-28, 35% id in 280 aa, and to Pseudomonas aeruginosa probable 3-mercaptopyruvate sulfurtransferase SseA or PA1292 SWALL:THTM_PSEAE (SWALL:Q9I452) (284 aa) fasta scores: E(): 2.4e-28, 36.07% id in 280 aa; sulfultransferase complement(2149289..2150113) Corynebacterium diphtheriae NCTC 13129 2649566 NP_940416.1 CDS DIP2100 NC_002935.2 2150259 2150489 R hypothetical protein complement(2150259..2150489) Corynebacterium diphtheriae NCTC 13129 2649567 NP_940417.1 CDS clpB2 NC_002935.2 2150689 2150889 R Similar to Corynebacterium glutamicum ClpB protein SWALL:CLPB_CORGL (SWALL:P53532) (852 aa) fasta scores: E(): 0.027, 44.44% id in 99 aa, and to Mycobacterium leprae heat shock protein ClpB or ML2490 SWALL:Q9CB26 (EMBL:AL583925) (848 aa) fasta scores: E(): 0.66, 35.41% id in 96 aa. Note: Similar also to the C-terminal part of DIP2104 (849 aa) E(): 7.2e-08; 53.465% identity in 101 aa overlap; heat shock protein (partial) complement(2150689..2150889) Corynebacterium diphtheriae NCTC 13129 2649568 NP_940418.1 CDS DIP2102 NC_002935.2 2151027 2151551 R hypothetical protein complement(2151027..2151551) Corynebacterium diphtheriae NCTC 13129 2649569 NP_940419.1 CDS DIP2103 NC_002935.2 2151552 2151704 R hypothetical protein complement(2151552..2151704) Corynebacterium diphtheriae NCTC 13129 2649570 NP_940420.1 CDS clpB NC_002935.2 2151849 2154398 R Similar to Escherichia coli ClpB or HtpM or B2592 or Z3886 or ECS3455 SW:CLPB_ECOLI (P03815) (857 aa) fasta scores: E(): 2.3e-133, 56.67% id in 847 aa, and to Corynebacterium glutamicum ClpB SW:CLPB_CORGL (P53532) (852 aa) fasta scores: E(): 0, 85.25% id in 841 aa; ATP-dependent protease regulatory subunit, ClpB complement(2151849..2154398) Corynebacterium diphtheriae NCTC 13129 2649571 NP_940421.1 CDS DIP2105 NC_002935.2 2154597 2154926 R Similar to the N-terminal portion of many from actinomycetes eg. Streptomyces coelicolor secreted protein SCE41.06c TR:Q9F2Q2 (EMBL:AL442120) (244 aa) fasta scores: E(): 7.5e-21, 65.74% id in 108 aa. Also full length similarity to others from actinomycetes eg. Streptomyces coelicolor membrane protein SC5C11.15 TR:Q9L157 (EMBL:AL158060) (121 aa) fasta scores: E(): 1.9e-14, 50.49% id in 101 aa; hypothetical protein complement(2154597..2154926) Corynebacterium diphtheriae NCTC 13129 2649572 NP_940422.1 CDS DIP2106 NC_002935.2 2155054 2155842 D Similar to Streptomyces coelicolor ABC transport system ATP-binding protein SCD10.29c TR:Q9K3U8 (EMBL:AL359988) (263 aa) fasta scores: E(): 8.8e-37, 49.6% id in 252 aa, and to Caulobacter crescentus ABC transporter, ATP-binding protein CC0838 TR:Q9A9X3 (EMBL:AE005760) (250 aa) fasta scores: E(): 2.6e-27, 42.25% id in 239 aa; ABC transporter ATP-binding protein 2155054..2155842 Corynebacterium diphtheriae NCTC 13129 2649573 NP_940423.1 CDS DIP2107 NC_002935.2 2155844 2157412 D Similar to Streptomyces coelicolor integral membrane transport protein SCD10.28c TR:Q9K3U9 (EMBL:AL359988) (550 aa) fasta scores: E(): 6.2e-18, 25.27% id in 542 aa. Lies alongside a ABC transporter ATP-binding subunit; integral membrane transport protein 2155844..2157412 Corynebacterium diphtheriae NCTC 13129 2649574 NP_940424.1 CDS DIP2108 NC_002935.2 2157906 2159243 R Weakly similar to many eg. Pseudomonas aeruginosa sodium/glutamate symporter GltS or PA3176 TR:Q9HZ58 (EMBL:AE004741) (404 aa) fasta scores: E(): 2.2e-06, 23.83% id in 365 aa, and to Escherichia coli sodium/glutamate symport carrier protein GltS or GltC or B3653 SW:GLTS_ECOLI (P19933) (401 aa) fasta scores: E(): 0.097, 22.36% id in 398 aa; hypothetical protein complement(2157906..2159243) Corynebacterium diphtheriae NCTC 13129 2649575 NP_940425.1 CDS DIP2109 NC_002935.2 2159370 2160410 R Similar to Rhizobium loti MLL2462 protein TR:Q98IC8 (EMBL:AP002999) (352 aa) fasta scores: E(): 1.7e-36, 37.16% id in 339 aa; integral membrane protein complement(2159370..2160410) Corynebacterium diphtheriae NCTC 13129 2649576 NP_940426.1 CDS DIP2110 NC_002935.2 2160416 2161519 D Similar to Mycobacterium bovis 47 kDa protein Rv0385 or MT0398 or MTV036.20 TR:O86363 (EMBL:U73653) (390 aa) fasta scores: E(): 4.7e-29, 36.36% id in 352 aa, and to Acinetobacter calcoaceticus phenolhydroxylase component TR:Q43983 (EMBL:Z36909) (350 aa) fasta scores: E(): 2.2e-06, 25.61% id in 246 aa, and to Pseudomonas sp phenol hydroxylase P5 protein DmpP SW:DMPP_PSESP (P19734) (352 aa) fasta scores: E(): 8.3e-06, 24.3% id in 251 aa; hypothetical protein 2160416..2161519 Corynebacterium diphtheriae NCTC 13129 2649577 NP_940427.1 CDS DIP2111 NC_002935.2 2161498 2162268 R Similar to Mycobacterium leprae hydrolase ML2449 TR:Q9CB47 (EMBL:AL583925) (271 aa) fasta scores: E(): 4.8e-37, 47.84% id in 255 aa, and to Mus musculus Nit protein 2 or 1190017B19riK TR:Q9JHW2 (EMBL:AF284573) (276 aa) fasta scores: E(): 2.7e-17, 29.88% id in 251 aa; hydrolase complement(2161498..2162268) Corynebacterium diphtheriae NCTC 13129 2649578 NP_940428.1 CDS DIP2112 NC_002935.2 2162322 2162480 R Doubtful CDS. No significant database matches. No stong consensus RBS. Predicted by Frameplot; hypothetical protein complement(2162322..2162480) Corynebacterium diphtheriae NCTC 13129 2649579 NP_940429.1 CDS DIP2113 NC_002935.2 2162652 2163782 D hypothetical protein 2162652..2163782 Corynebacterium diphtheriae NCTC 13129 2649580 NP_940430.1 CDS adhA NC_002935.2 2163769 2164809 R Similar to Rhizobium meliloti alcohol dehydrogenase AdhA or RA0704 or SMA1296 SWALL:ADHA_RHIME (SWALL:O31186) (340 aa) fasta scores: E(): 1.4e-71, 55.09% id in 334 aa, and to Pseudomonas aeruginosa alcohol dehydrogenase AdhA or PA5427 SWALL:Q9HTD9 (EMBL:AE004955) (342 aa) fasta scores: E(): 1.5e-79, 58.99% id in 339 aa; alcohol dehydrogenase complement(2163769..2164809) Corynebacterium diphtheriae NCTC 13129 2649581 NP_940431.1 CDS DIP2115 NC_002935.2 2164963 2166483 R Similar to many eg. Acinetobacter spM-1. aldehyde dehydrogenase 1 Ald1 TR:Q9FDS1 (EMBL:AB042203) (503 aa) fasta scores: E(): 2.5e-143, 69.18% id in 503 aa, and to Alcaligenes eutrophus acetaldehyde dehydrogenase II AcoD SW:DHA2_ALCEU (P46368) (506 aa) fasta scores: E(): 1.8e-135, 66.39% id in 497 aa; aldehyde dehydrogenase complement(2164963..2166483) Corynebacterium diphtheriae NCTC 13129 2649582 NP_940432.1 CDS DIP2116 NC_002935.2 2166772 2168376 D No significant database matches. Lies in a DNA region of unusually low G+C content.; membrane anchored protein 2166772..2168376 Corynebacterium diphtheriae NCTC 13129 2649583 NP_940433.1 CDS hspR NC_002935.2 2168433 2168831 R Similar to Streptomyces coelicolor heat shock protein HspR or SCH44.08c SW:HSPR_STRCO (P40183) (151 aa) fasta scores: E(): 5.4e-16, 52.59% id in 135 aa, and to Mycobacterium tuberculosis HspR or Rv0353 or MTCY13E10.13 TR:O06302 (EMBL:Z95324) (126 aa) fasta scores: E(): 6.6e-23, 66.66% id in 117 aa; chaperone locus transcriptional regulator, HspR complement(2168433..2168831) Corynebacterium diphtheriae NCTC 13129 2649584 NP_940434.1 CDS dnaJ1 NC_002935.2 2168853 2170025 R chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ complement(2168853..2170025) Corynebacterium diphtheriae NCTC 13129 2649585 NP_940435.1 CDS grpE NC_002935.2 2170135 2170794 R with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE complement(2170135..2170794) Corynebacterium diphtheriae NCTC 13129 2649586 NP_940436.1 CDS dnaK NC_002935.2 2170794 2172629 R heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK complement(2170794..2172629) Corynebacterium diphtheriae NCTC 13129 2649587 NP_940437.1 CDS DIP2121 NC_002935.2 2173043 2174347 D Some similarity to integral membrane sensory proteins though DIP2121 does not appear to be a membrane protein. Similar to Rhodobacter capsulatus potential sensory protein TR:O68073 (EMBL:AF010496) (416 aa) fasta scores: E(): 1.6e-11, 27.93% id in 426 aa, and to Escherichia coli ORFI protein TR:Q56321 (EMBL:X61367) (525 aa) fasta scores: E(): 2.2e-09, 25.78% id in 446 aa, and to Escherichia coli aerotaxis receptor Aer or Air or B3072 SW:AER_ECOLI (P50466) (506 aa) fasta scores: E(): 1e-08, 25.29% id in 423 aa; hypothetical protein 2173043..2174347 Corynebacterium diphtheriae NCTC 13129 2649588 NP_940438.1 CDS DIP2122 NC_002935.2 2174439 2175719 D Similar to Streptomyces coelicolor integral membrane protein SCF6.09 TR:Q9RJL9 (EMBL:AL121849) (363 aa) fasta scores: E(): 3.1e-49, 44.27% id in 332 aa, and to Escherichia coli permease B2493 or Z3755 or ECS3355 SW:PERM_ECOLI (P77406) (353 aa) fasta scores: E(): 1.7e-18, 27.89% id in 337 aa; hypothetical protein 2174439..2175719 Corynebacterium diphtheriae NCTC 13129 2649589 NP_940439.1 CDS DIP2123 NC_002935.2 2175813 2176625 R Similar to Escherichia coli transposase InsK for insertion sequence element IS150 or B3558 SW:INSK_ECOLI (P19769) (283 aa) fasta scores: E(): 1.4e-43, 44.86% id in 263 aa. Identical to DIP0434, DIP1517, DIP1526 and DIP1809; transposase complement(2175813..2176625) Corynebacterium diphtheriae NCTC 13129 2649590 NP_940440.1 CDS DIP2124 NC_002935.2 2176673 2177155 R Similar to Streptococcus pneumoniae hypothetical 20.7 kDa protein TR:Q9KK22 (EMBL:AF154034) (171 aa) fasta scores: E(): 1.3e-08, 33.75% id in 157 aa, and to Yersinia pestis insertion element IS1661 DNA-binding protein YPO3931 TR:CAC93394 (EMBL:AJ414159) (171 aa) fasta scores: E(): 0.00044, 25.45% id in 165 aa. Identical to DIP0435, DIP1518, DIP1525 and DIP1808; insertion element DNA-binding protein complement(2176673..2177155) Corynebacterium diphtheriae NCTC 13129 2649591 NP_940441.1 CDS DIP2125 NC_002935.2 2177232 2177873 R Similar to Streptomyces coelicolor ABC transporter ATP-binding protein SC9B5.22 TR:Q9ZBF8 (EMBL:AL035206) (222 aa) fasta scores: E(): 7.5e-19, 41.66% id in 216 aa, and to Escherichia coli nickel transport ATP-binding protein NikE or B3480 SW:NIKE_ECOLI (P33594) (268 aa) fasta scores: E(): 6.3e-17, 38.72% id in 204 aa; ABC transporter ATP-binding protein complement(2177232..2177873) Corynebacterium diphtheriae NCTC 13129 2649592 NP_940442.1 CDS DIP2126 NC_002935.2 2177860 2179488 R Similar to Streptomyces coelicolor transport permease SC9B5.20 TR:Q9ZBG0 (EMBL:AL035206) (312 aa) fasta scores: E(): 4.4e-32, 45.27% id in 254 aa, and to Bacillus subtilis dipeptide transport system permease DppC or DciAC SW:DPPC_BACSU (P26904) (320 aa) fasta scores: E(): 4.3e-23, 37.19% id in 242 aa; binding-protein-dependent integral membrane transport protein complement(2177860..2179488) Corynebacterium diphtheriae NCTC 13129 2649593 NP_940443.1 CDS DIP2127 NC_002935.2 2179481 2180479 R Similar to Streptomyces coelicolor transport permease SC9B5.19 TR:Q9ZBG1 (EMBL:AL035206) (334 aa) fasta scores: E(): 8.6e-44, 43.51% id in 324 aa, and to Bacillus subtilis oligopeptide transport system permease AppB SW:APPB_BACSU (P42062) (317 aa) fasta scores: E(): 6.2e-25, 28.61% id in 318 aa; binding-protein-dependent integral membrane transport protein complement(2179481..2180479) Corynebacterium diphtheriae NCTC 13129 2649594 NP_940444.1 CDS DIP2128 NC_002935.2 2180480 2182084 R Similar to Streptomyces coelicolor substrate binding protein SC9B5.18 TR:Q9ZBG2 (EMBL:AL035206) (542 aa) fasta scores: E(): 2e-50, 33.14% id in 516 aa, and to Streptomyces lividans Xp55 protein SW:XP55_STRLI (P06109) (542 aa) fasta scores: E(): 1.7e-43, 32.16% id in 485 aa; substrate-binding transport protein complement(2180480..2182084) Corynebacterium diphtheriae NCTC 13129 2649595 NP_940445.1 CDS DIP2129 NC_002935.2 2182285 2183871 R Similar to Mycobacterium tuberculosis phosphate permease Rv2281 or MT2339 or MTCY339.29C SW:YM81_MYCTU (Q50684) (552 aa) fasta scores: E(): 1.2e-121, 61% id in 518 aa; binding-protein-dependent integral membrane transport protein complement(2182285..2183871) Corynebacterium diphtheriae NCTC 13129 2649596 NP_940446.1 CDS DIP2130 NC_002935.2 2190630 2194346 D Full length similarity to Streptococcus pneumoniae phosphoribosylformylglycinamidine synthase, SP0045 TR:AAK74234 (EMBL:AE007322) (1241 aa) fasta scores: E(): 7.8e-167, 47.73% id in 1259 aa. Second two thirds similar to many others e.g. Mycobacterium tuberculosis phosphoribosylformylglycinamidine synthase II PurL or Rv0803 or MT0823 or MTCY07H7A.06c SW:PURL_MYCTU (P54876) (754 aa) fasta scores: E(): 8.3e-22, 26.35% id in 740 aa; phosphoribosylformylglycinamidine synthase 2190630..2194346 Corynebacterium diphtheriae NCTC 13129 2649600 NP_940447.1 CDS DIP2131 NC_002935.2 2194426 2195016 R Catalyzes hydrolysis of n-ribosyl-purine into a purine and d-ribose; nucleosidase complement(2194426..2195016) Corynebacterium diphtheriae NCTC 13129 2649601 NP_940448.1 CDS DIP2132 NC_002935.2 2195144 2195632 D Weakly similar to Rattus norvegicus NADPH:adrenodoxin oxidoreductase, mitochondrial precursor FdxR SW:ADRO_RAT (P56522) (494 aa) fasta scores: E(): 0.002, 28.3% id in 159 aa, and to Streptomyces coelicolor ferredoxin/ferredoxin-NADP reductase SCF15.02 TR:Q9RK35 (EMBL:AL132856) (454 aa) fasta scores: E(): 0.048, 29% id in 131 aa; oxidoreductase 2195144..2195632 Corynebacterium diphtheriae NCTC 13129 2649602 NP_940449.1 CDS DIP2133 NC_002935.2 2195706 2198210 D Similar to many eg. Mycobacterium tuberculosis hypothetical 95.5 kDa protein Rv0338c or MT0352 or MTCY279.05C TR:O33268 (EMBL:Z97991) (882 aa) fasta scores: E(): 2.4e-55, 43.1% id in 877 aa. N-terminal region appears to be has possible membrane-spanning hydrophobic regions while the C-terminal region is rich in proline and alanine.; hypothetical protein 2195706..2198210 Corynebacterium diphtheriae NCTC 13129 2649603 NP_940450.1 CDS DIP2134 NC_002935.2 2198286 2198906 D N-terminus similar to those from other actinomycetes eg. Saccharopolyspora erythraea Orf122 protein TR:Q54106 (EMBL:X92556) (121 aa) fasta scores: E(): 0.0076, 31.15% id in 138 aa, and to Streptomyces coelicolor hypothetical 30.8 kDa protein SCE6.30c TR:Q9KZR0 (EMBL:AL353832) (277 aa) fasta scores: E(): 0.02, 36.76% id in 68 aa; hypothetical protein 2198286..2198906 Corynebacterium diphtheriae NCTC 13129 2649604 NP_940451.1 CDS DIP2135 NC_002935.2 2198998 2200089 R Similar to Neisseria meningitidis zinc-binding alcohol dehydrogenase NMA0808 TR:Q9JVJ8 (EMBL:AL162754) (354 aa) fasta scores: E(): 1.1e-85, 64.62% id in 359 aa, and to Bacillus cereus acetylacetoin reductase AacR TR:BAB60856 (EMBL:AB063194) (349 aa) fasta scores: E(): 5.6e-47, 42.25% id in 355 aa, and to Pseudomonas putida 2,3-butanediol dehydrogenase Adh TR:Q59696 (EMBL:L35343) (362 aa) fasta scores: E(): 6.6e-40, 37.63% id in 364 aa; zinc-binding alcohol dehydrogenase complement(2198998..2200089) Corynebacterium diphtheriae NCTC 13129 2649605 NP_940452.1 CDS DIP2136 NC_002935.2 2200331 2201602 D broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase 2200331..2201602 Corynebacterium diphtheriae NCTC 13129 2649606 NP_940453.1 CDS DIP2137 NC_002935.2 2201757 2202914 D Similar to Streptomyces coelicolor membrane protein SCQ11.10c TR:Q9X9U1 (EMBL:AL096823) (513 aa) fasta scores: E(): 2.1e-35, 37.59% id in 383 aa, and to Pseudomonas aeruginosa sensor protein GlpS or pa1977 SW:GLPS_PSEAE (P29370) (287 aa) fasta scores: E(): 2.5, 29.41% id in 238 aa; hypothetical protein 2201757..2202914 Corynebacterium diphtheriae NCTC 13129 2649607 NP_940454.1 CDS lysS NC_002935.2 2202940 2206089 D catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 2202940..2206089 Corynebacterium diphtheriae NCTC 13129 2649608 NP_940455.1 CDS DIP2139 NC_002935.2 2206196 2206873 R hypothetical protein complement(2206196..2206873) Corynebacterium diphtheriae NCTC 13129 2649609 NP_940456.1 CDS DIP2140 NC_002935.2 2206836 2207456 R Weakly similar to Lactococcus lactis unknown protein YldA or ll1118 TR:Q9CGH8 (EMBL:AE006344) (209 aa) fasta scores: E(): 0.092, 24% id in 175 aa; integral membrane protein complement(2206836..2207456) Corynebacterium diphtheriae NCTC 13129 2649610 NP_940457.1 CDS DIP2141 NC_002935.2 2207481 2208686 R Similar to Streptomyces coelicolor UDP-glucose 6-dehydrogenase SCBAC19G2.07 TR:CAC44517 (EMBL:AL596138) (447 aa) fasta scores: E(): 2.8e-33, 40.75% id in 422 aa, and to Pseudomonas aeruginosa UDP-glucose 6-dehydrogenase Udg or pa2022 SW:UDG_PSEAE (O86422) (453 aa) fasta scores: E(): 1.9e-26, 39.66% id in 358 aa, and to Rhizobium meliloti UDP-glucose 6-dehydrogenase Rkpk or r01082 or smc02641 SW:UDG_RHIME (O54068) (437 aa) fasta scores: E(): 8.9e-26, 37.71% id in 411 aa, and to Escherichia coli UDP-glucose 6-dehydrogenase KfiD SW:UDG5_ECOLI (Q47329) (392 aa) fasta scores: E(): 1.5e-24, 32.81% id in 323 aa; UDP-glucose 6-dehydrogenase complement(2207481..2208686) Corynebacterium diphtheriae NCTC 13129 2649611 NP_940458.1 CDS dcd NC_002935.2 2208692 2209255 R Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase complement(2208692..2209255) Corynebacterium diphtheriae NCTC 13129 2649612 NP_940459.1 CDS DIP2143 NC_002935.2 2209550 2210329 R Weakly similar to Bacillus subtilis hypothetical YxlG TR:P94375 (EMBL:D83026) (259 aa) fasta scores: E(): 1.2, 24.72% id in 182 aa, and to Rhizobium loti Mll2378 protein TR:Q98IJ2 (EMBL:AP002999) (339 aa) fasta scores: E(): 1.3, 26.98% id in 252 aa. Lies alongside a ABC transporter ATP-binding subunit.; ABC transporter inner membrane protein complement(2209550..2210329) Corynebacterium diphtheriae NCTC 13129 2649614 NP_940460.1 CDS DIP2144 NC_002935.2 2210326 2211159 R Similar to many eg. Bacillus licheniformis bacitracin transport ATP-binding protein BcrA SW:BCRA_BACLI (P42332) (306 aa) fasta scores: E(): 2.7e-22, 35.01% id in 277 aa; ABC transporter ATP-binding protein complement(2210326..2211159) Corynebacterium diphtheriae NCTC 13129 2649615 NP_940461.1 CDS DIP2145 NC_002935.2 2211156 2211488 R hypothetical protein complement(2211156..2211488) Corynebacterium diphtheriae NCTC 13129 2649616 NP_940462.1 CDS DIP2146 NC_002935.2 2211488 2212180 R hypothetical protein complement(2211488..2212180) Corynebacterium diphtheriae NCTC 13129 2649617 NP_940463.1 CDS DIP2147 NC_002935.2 2212180 2212506 R Similar to Streptomyces coelicolor conserved hypothetical protein SCE20.33c TR:Q9RD92 (EMBL:AL136058) (125 aa) fasta scores: E(): 3e-12, 44.79% id in 96 aa, and to Caulobacter crescentus hypothetical protein Cc3408 TR:Q9A2Z8 (EMBL:AE006001) (108 aa) fasta scores: E(): 2.9e-10, 42.26% id in 97 aa; hypothetical protein complement(2212180..2212506) Corynebacterium diphtheriae NCTC 13129 2649618 NP_940464.1 CDS DIP2152 NC_002935.2 2213799 2214419 R hypothetical protein complement(2213799..2214419) Corynebacterium diphtheriae NCTC 13129 2649621 NP_940465.1 CDS DIP2153 NC_002935.2 2214506 2214883 R Similar to Bacteriophage phi-105 holin TR:Q38456 (EMBL:L35561) (124 aa) fasta scores: E(): 5.4e-14, 41.22% id in 114 aa, and to Escherichia coli O157:H7 holin protein of prophage cp-933c Z1852 or ECS1595 TR:AAG55949 (EMBL:AE005328) (129 aa) fasta scores: E(): 1.7e-07, 40.77% id in 103 aa; bacteriophage holin protein complement(2214506..2214883) Corynebacterium diphtheriae NCTC 13129 2649622 NP_940466.1 CDS DIP2154 NC_002935.2 2214765 2215559 R Similar to Xylella fastidiosa phage-related protein XF0684 TR:Q9PFH4 (EMBL:AE003912) (503 aa) fasta scores: E(): 1.8e-13, 56.52% id in 92 aa, and to Lactobacillus casei bacteriophage A2 Antirepressor Ant TR:O64368 (EMBL:AJ251789) (160 aa) fasta scores: E(): 2.9e-08, 36.69% id in 139 aa, and to Bacteriophage r1t integrase, repressor protein TR:Q38091 (EMBL:U38906) (265 aa) fasta scores: E(): 2.3e-06, 36.98% id in 219 aa; DNA-binding bacteriophage protein complement(2214765..2215559) Corynebacterium diphtheriae NCTC 13129 2649623 NP_940467.1 CDS DIP2155 NC_002935.2 2215819 2216805 D Similar to Pasteurella multocida hypothetical protein Pm1783 TR:Q9CK51 (EMBL:AE006215) (316 aa) fasta scores: E(): 1.4e-26, 32.226% id in 301 aa, and to Staphylococcus aureus subspaureus Mu50. hypothetical 38.5 kDa protein Sav0801 TR:BAB56963 (EMBL:AP003360) (322 aa) fasta scores: E(): 2.7e-07, 22.876% id in 306 aa; hypothetical protein 2215819..2216805 Corynebacterium diphtheriae NCTC 13129 2649624 NP_940468.1 CDS DIP2158 NC_002935.2 2217901 2219655 R Similar to Yersinia pestis YbtP TR:Q9ZG01 (EMBL:AF091251) (600 aa) fasta scores: E(): 5e-46, 31.046% id in 583 aa, and to Escherichia coli, and probable transport ATP-binding protein MsbA or B0914 or Z1260 or ECS0997 SW:MSBA_ECOLI (P27299) (582 aa) fasta scores: E(): 1.6e-42, 30.969% id in 578 aa; ABC transporter complement(2217901..2219655) Corynebacterium diphtheriae NCTC 13129 2649626 NP_940469.1 CDS DIP2159 NC_002935.2 2219658 2221439 R Similar to Yersinia enterocolitica lipoprotein inner membrane ABC-transporter, Irp6 TR:Q9X9I5 (EMBL:AJ132668) (600 aa) fasta scores: E(): 2.5e-43, 34.286% id in 560 aa, and to Streptomyces natalensis PimB protein TR:Q9EW97 (EMBL:AJ278573) (626 aa) fasta scores: E(): 3e-37, 32.519% id in 532 aa; ABC transporter complement(2219658..2221439) Corynebacterium diphtheriae NCTC 13129 2649627 NP_940470.1 CDS DIP2160 NC_002935.2 2221492 2229396 R Similar to Streptomyces verticillus polyketide synthase BlmVIII (bleomycin biosynthesis) TR:Q9FB25 (EMBL:AF210249) (1841 aa) fasta scores: E(): 1.3e-72, 27.240% id in 1931 aa, and to Streptomyces noursei nystatin biosynthesis polyketide synthase Nys TR:Q9L4W3 (EMBL:AF263912) (11096 aa) fasta scores: E(): 4e-71, 33.107% id in 882 aa, and to Amycolatopsis mediterranei rifamycin polyketide synthase TR:Q9F847 (EMBL:AF262754) (1265 aa) fasta scores: E(): 7.7e-61, 31.042% id in 902 aa; modular polyketide synthase complement(2221492..2229396) Corynebacterium diphtheriae NCTC 13129 2649628 NP_940471.1 CDS DIP2161 NC_002935.2 2229393 2234573 R Similar to Stigmatella aurantiaca myxothiazol synthase MtaC TR:Q9RFK9 (EMBL:AF188287) (1290 aa) fasta scores: E(): 1.7e-86, 35.694% id in 1073 aa, and to Polyangium cellulosum epothilone biosynthase EpoB TR:Q9KIZ9 (EMBL:AF217189) (1410 aa) fasta scores: E(): 1.8e-81, 35.385% id in 975 aa, and to Pseudomonas aeruginosa pyochelin synthetase PchF or PA4225 TR:Q9HWG4 (EMBL:AE004839) (1809 aa) fasta scores: E(): 1.9e-81, 37.017% id in 932 aa; non-ribosomal peptide synthetase complement(2229393..2234573) Corynebacterium diphtheriae NCTC 13129 2649629 NP_940472.1 CDS DIP2162 NC_002935.2 2234961 2236460 D Similar to Streptomyces coelicolor secreted solute-binding protein SC4C2.12 TR:Q9EWQ0 (EMBL:AL450432) (528 aa) fasta scores: E(): 4.7e-23, 29.923% id in 518 aa, and to Rhizobium loti ABC transporter, binding protein MLL5127 TR:Q98CJ3 (EMBL:AP003005) (528 aa) fasta scores: E(): 1.4e-22, 27.921% id in 505 aa. Note: Contains a twin-arginine translocation (TAT) system recognition motif (RRDFLK) at the N-terminal region; ABC transporter substrate-binding protein 2234961..2236460 Corynebacterium diphtheriae NCTC 13129 2649630 NP_940473.1 CDS DIP2163 NC_002935.2 2236473 2237426 D Similar to Streptomyces coelicolor metal transport integral membrane protein SC4C2.13 TR:Q9EWP9 (EMBL:AL450432) (316 aa) fasta scores: E(): 3.2e-30, 39.344% id in 305 aa, and to Rhizobium meliloti ABC transporter permease SMA0300 TR:AAK64819 (EMBL:AE007209) (317 aa) fasta scores: E(): 2.1e-20, 27.303% id in 304 aa; ABC transporter permease 2236473..2237426 Corynebacterium diphtheriae NCTC 13129 2649631 NP_940474.1 CDS DIP2164 NC_002935.2 2237423 2238244 D Similar to Streptomyces coelicolor transport system integral membrane protein SC4C2.14 TR:Q9EWP8 (EMBL:AL450432) (284 aa) fasta scores: E(): 4.4e-17, 32.567% id in 261 aa, and to Rhizobium loti ABC transporter, permease MLL7032 TR:Q987J0 (EMBL:AP003010) (283 aa) fasta scores: E(): 1.9e-14, 30.859% id in 256 aa; ABC transporter permease 2237423..2238244 Corynebacterium diphtheriae NCTC 13129 2648910 NP_940475.1 CDS DIP2165 NC_002935.2 2238241 2239647 D Similar to Rhizobium meliloti ABC transporter SMA0298 TR:AAK64817 (EMBL:AE007209) (604 aa) fasta scores: E(): 1.5e-15, 27.536% id in 552 aa, and to Streptomyces coelicolor peptide transport ATP-binding protein SC9F2.04 TR:Q9Z531 (EMBL:AL035559) (359 aa) fasta scores: E(): 3.4e-15, 39.409% id in 203 aa; ABC transporter ATP-binding protein 2238241..2239647 Corynebacterium diphtheriae NCTC 13129 2648911 NP_940476.1 CDS DIP2166 NC_002935.2 2239756 2241060 D Similar to Amycolatopsis orientalis integral membrane sugar transporter CZA382.17c TR:Q9XBD4 (EMBL:AL078635) (444 aa) fasta scores: E(): 3.8e-43, 37.264% id in 424 aa, and to Burkholderia cepacia MopB protein TR:Q45082 (EMBL:U29532) (449 aa) fasta scores: E(): 1.2e-40, 35.885% id in 418 aa; ABC transporter permease 2239756..2241060 Corynebacterium diphtheriae NCTC 13129 2648912 NP_940477.1 CDS metE NC_002935.2 2241109 2241360 D Similar to fragment of Mycobacterium tuberculosis 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase MetE or Rv1133c or MT1165 or MTC22G8.22 SW:METE_MYCTU (O06584) (759 aa) fasta scores: E(): 2.5e-06, 70.732% id in 41 aa, and to Streptomyces griseus subspgriseus. 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase- like protein TR:Q9KHC5 (EMBL:AF263012) (774 aa) fasta scores: E(): 4.1e-06, 77.778% id in 36 aa, and to Saccharomyces cerevisiae 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase Met6 or YER091c SW:METE_YEAST (P05694) (766 aa) fasta scores: E(): 7.8e-05, 71.429% id in 35 aa; 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase 2241109..2241360 Corynebacterium diphtheriae NCTC 13129 2648913 NP_940478.1 CDS DIP2168 NC_002935.2 2241389 2242600 D Similar to Streptomyces coelicolor membrane transport protein SCC75A.30c TR:Q9RKP4 (EMBL:AL133220) (428 aa) fasta scores: E(): 5.2e-40, 36.935% id in 398 aa, and to Escherichia coli bicyclomycin resistance protein Bcr or BicA or BicR or Sur or SuxA or b2182 SW:BCR_ECOLI (P28246) (396 aa) fasta scores: E(): 3.4e-31, 30.548% id in 383 aa; integral membrane transport protein 2241389..2242600 Corynebacterium diphtheriae NCTC 13129 2648914 NP_940479.1 CDS DIP2169 NC_002935.2 2242597 2244075 R hypothetical protein complement(2242597..2244075) Corynebacterium diphtheriae NCTC 13129 2648915 NP_940480.1 CDS DIP2170 NC_002935.2 2244077 2244868 R Similar to Bacillus subtilis hypothetical 27.6 kDa protein in fnr-narG intergenic region YwiC SW:YWIC_BACSU (P46909) (239 aa) fasta scores: E(): 5e-08, 28.571% id in 259 aa, and to Haemophilus influenzae hypothetical protein HI1626 SW:YG26_HAEIN (P44278) (238 aa) fasta scores: E(): 3.6e-06, 25.758% id in 264 aa; hypothetical protein complement(2244077..2244868) Corynebacterium diphtheriae NCTC 13129 2648916 NP_940481.1 CDS DIP2171 NC_002935.2 2244892 2246574 R hypothetical protein complement(2244892..2246574) Corynebacterium diphtheriae NCTC 13129 2648917 NP_940482.1 CDS DIP2172 NC_002935.2 2246580 2247743 R Similar to Mycobacterium leprae secreted glycosyl hydrolase ML2569 or MLCB1883.14 TR:O69499 (EMBL:AL022486) (387 aa) fasta scores: E(): 3e-40, 42.33% id in 385 aa, and to Vibrio furnissii beta-hexosaminidase NagZ or Exo II SW:NAGZ_VIBFU (P96157) (329 aa) fasta scores: E(): 9e-13, 30.94% id in 265 aa. Note: Contains a twin-arginine translocation (TAT) system recognition motif (RRVFTP) at the N-terminal region; secreted glycosyl hydrolase complement(2246580..2247743) Corynebacterium diphtheriae NCTC 13129 2648918 NP_940483.1 CDS DIP2173 NC_002935.2 2247778 2247966 D Similar to Mycobacterium tuberculosis secreted protein Rv0236.1 precursor or Rv0236A or MT0250 SW:Y23A_MYCTU (P58240) (57 aa) fasta scores: E(): 0.39, 32.72% id in 55 aa; hypothetical protein 2247778..2247966 Corynebacterium diphtheriae NCTC 13129 2648919 NP_940484.1 CDS DIP2174 NC_002935.2 2247967 2251044 D Similar to Mycobacterium leprae possible integral membrane protein ML2570 TR:Q9CD19 (EMBL:AL583926) (1405 aa) fasta scores: E(): 2.5e-17, 37.3% id in 823 aa, and to Mycobacterium tuberculosis hypothetical 146.3 kDa protein Rv0236c or MT0247 or MTV034.01c or MTV034.02c or MTCY08D5.32c TR:AAK44467 (EMBL:Z92669) (1400 aa) fasta scores: E(): 7.4e-17, 38.32% id in 822 aa. ORF overlaps with convergent downstream ORF; hypothetical protein 2247967..2251044 Corynebacterium diphtheriae NCTC 13129 2648920 NP_940485.1 CDS DIP2175 NC_002935.2 2250936 2252075 R Similar to Mycobacterium tuberculosis hypothetical 43.3 kDa protein Rv0228 or MT0238 or MTCY08D5.23 TR:P96410 (EMBL:Z92669) (407 aa) fasta scores: E(): 1.2e-31, 38.84% id in 381 aa, and to Streptomyces thermotolerans macrolide antibiotics 3-O-acyltransferase AcyA TR:Q56074 (EMBL:D30759) (389 aa) fasta scores: E(): 6e-07, 30.43% id in 322 aa, and to Streptomyces mycarofaciens acyltransferase MdmB SW:MDMB_STRMY (Q00718) (387 aa) fasta scores: E(): 8e-07, 29.14% id in 398 aa. ORF overlaps with convergent downstream ORF.; integral membrane acyltransferase complement(2250936..2252075) Corynebacterium diphtheriae NCTC 13129 2648921 NP_940486.1 CDS DIP2176 NC_002935.2 2252088 2253182 D Similar to Mycobacterium leprae integral membrane protein Ml2581 TR:Q9CD18 (EMBL:AL583926) (427 aa) fasta scores: E(): 8.6e-14, 27.79% id in 367 aa; integral membrane protein 2252088..2253182 Corynebacterium diphtheriae NCTC 13129 2648922 NP_940487.1 CDS DIP2177 NC_002935.2 2253173 2254585 D Similar to Mycobacterium tuberculosis hypothetical 59.1 kDa protein Rv0226c or MTCY08D5.21c TR:P96408 (EMBL:Z92669) (576 aa) fasta scores: E(): 6e-08, 30% id in 530 aa. ORF overlaps with convergent downstream ORF; hypothetical protein 2253173..2254585 Corynebacterium diphtheriae NCTC 13129 2648923 NP_940488.1 CDS DIP2178 NC_002935.2 2254468 2255622 R Similar to Mycobacterium tuberculosis hypothetical 42.1 kDa protein Rv0225 or MTCY08D5.20 TR:P96407 (EMBL:Z92669) (384 aa) fasta scores: E(): 3.5e-62, 51.48% id in 371 aa. ORF overlaps with convergent downstream ORF; hypothetical protein complement(2254468..2255622) Corynebacterium diphtheriae NCTC 13129 2648924 NP_940489.1 CDS DIP2179 NC_002935.2 2255664 2256398 D Similar to Mycobacterium tuberculosis hypothetical 27.5 kDa protein Rv0224c or MTCY08D5.19c TR:P96406 (EMBL:Z92669) (254 aa) fasta scores: E(): 2.9e-56, 63.41% id in 246 aa, and to Streptomyces coelicolor methyltransferase SCC53.08c TR:Q9KXK3 (EMBL:AL357591) (244 aa) fasta scores: E(): 7.1e-06, 32.94% id in 173 aa; hypothetical protein 2255664..2256398 Corynebacterium diphtheriae NCTC 13129 2648925 NP_940490.1 CDS pckG NC_002935.2 2256423 2258261 R catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using GTP; phosphoenolpyruvate carboxykinase complement(2256423..2258261) Corynebacterium diphtheriae NCTC 13129 2648926 NP_940491.1 CDS trmB NC_002935.2 2258718 2259497 D tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 2258718..2259497 Corynebacterium diphtheriae NCTC 13129 2648927 NP_940492.1 CDS DIP2182 NC_002935.2 2259494 2260114 D Similar to Mycobacterium tuberculosis hypothetical 26.2 kDa protein Rv0207c or MT0217 or MTCY08D5.02c TR:AAK44438 (EMBL:Z92669) (244 aa) fasta scores: E(): 8.6e-51, 64.03% id in 203 aa; hypothetical protein 2259494..2260114 Corynebacterium diphtheriae NCTC 13129 2648928 NP_940493.1 CDS DIP2183 NC_002935.2 2260129 2262369 D Similar to Mycobacterium tuberculosis membrane protein MmpL3 or Rv0206c or MT0216 or MTV033.14c or MTCY08D5.01c SW:MML3_MYCTU (O53657) (944 aa) fasta scores: E(): 2.1e-45, 44.69% id in 754 aa, and to Streptomyces coelicolor integral membrane protein SCC24.25 TR:Q9L092 (EMBL:AL163003) (743 aa) fasta scores: E(): 4.6e-42, 34.79% id in 750 aa; integral membrane protein 2260129..2262369 Corynebacterium diphtheriae NCTC 13129 2648929 NP_940494.1 CDS DIP2184 NC_002935.2 2262371 2263414 D Similar to Mycobacterium tuberculosis hypothetical 44.0 kDa protein Rv0204c or MT0214 or MTV033.12c TR:O53655 (EMBL:AL021928) (412 aa) fasta scores: E(): 3.4e-15, 30.24% id in 324 aa; integral membrane protein 2262371..2263414 Corynebacterium diphtheriae NCTC 13129 2648930 NP_940495.1 CDS DIP2185 NC_002935.2 2263411 2263767 D Similar to Mycobacterium tuberculosis hypothetical 12.6 kDa protein Rv0401 or MTCY04D9.14 TR:P95210 (EMBL:Z84725) (123 aa) fasta scores: E(): 5.3e-11, 36.6% id in 112 aa; integral membrane protein 2263411..2263767 Corynebacterium diphtheriae NCTC 13129 2648931 NP_940496.1 CDS pccB NC_002935.2 2266345 2267895 R Similar to Streptomyces coelicolor propionyl-CoA carboxylase complex B subunit PccB TR:Q9X4K7 (EMBL:AF113605) (530 aa) fasta scores: E(): 8.2e-102, 52.29% id in 522 aa, and to Mycobacterium tuberculosis propionyl-CoA carboxylase AccD4 or Rv3799c or MTV026.04c TR:O53578 (EMBL:AL022076) (518 aa) fasta scores: E(): 2.2e-106, 54.51% id in 510 aa, and to Saccharopolyspora erythraea propionyl-CoA carboxylase beta chain PccB SW:PCCB_SACER (P53003) (546 aa) fasta scores: E(): 1.2e-88, 51.88% id in 530 aa; propionyl-CoA carboxylase subunit beta complement(2266345..2267895) Corynebacterium diphtheriae NCTC 13129 2648935 NP_940497.1 CDS DIP2189 NC_002935.2 2267907 2272667 R Similar to Mycobacterium tuberculosis polyketide synthase PKS13 or Rv3800c or MTV026.05c TR:O53579 (EMBL:AL022076) (1733 aa) fasta scores: E(): 5.4e-109, 44.5% id in 1719 aa, and to Polyangium cellulosum soraphen polyketide synthase A SorA TR:Q9ADL6 (EMBL:U24241) (6315 aa) fasta scores: E(): 6.2e-101, 35.96% id in 1090 aa; polyketide synthase complement(2267907..2272667) Corynebacterium diphtheriae NCTC 13129 2648936 NP_940498.1 CDS DIP2190 NC_002935.2 2272766 2274580 R Activates fatty acids by binding to coenzyme A; acyl-CoA synthetase complement(2272766..2274580) Corynebacterium diphtheriae NCTC 13129 2648937 NP_940499.1 CDS DIP2191 NC_002935.2 2274655 2275566 R Similar to Mycobacterium tuberculosis hypothetical 35.4 kDa protein Rv3802c or MTV026.07c TR:O53581 (EMBL:AL022076) (336 aa) fasta scores: E(): 3.2e-34, 41.32% id in 317 aa; hypothetical protein complement(2274655..2275566) Corynebacterium diphtheriae NCTC 13129 2648938 NP_940500.1 CDS DIP2192 NC_002935.2 2275572 2276087 R N-terminal region presents very low similarity to the following: Corynebacterium equii virulence associated protein VapA TR:Q9EUL9 (EMBL:AF116907) (189 aa) fasta scores: E(): 0.7, 27.92% id in 111 aa, and to Staphylococcus aureus hypothetical protein SAV2001 TR:BAB58163 (EMBL:AP003364) (154 aa) fasta scores: E(): 0.99, 26.61% id in 124 aa, and to Corynebacterium equii virulence-associated 15-17-kDa antigen VapA TR:Q57470 (EMBL:D21236) (189 aa) fasta scores: E(): 4.1, 27.02% id in 111 aa; hypothetical protein complement(2275572..2276087) Corynebacterium diphtheriae NCTC 13129 2648939 NP_940501.1 CDS csp1 NC_002935.2 2276087 2278003 R Similar to Corynebacterium glutamicum PS1 protein precursor Csp1 SW:CSP1_CORGL (Q01377) (657 aa) fasta scores: E(): 1.8e-147, 57.51% id in 659 aa, and similar to but longer than Mycobacterium intracellulare antigen 85-B precursor FbpB SW:A85B_MYCIT (Q49575) (330 aa) fasta scores: E(): 1.8e-29, 37.18% id in 320 aa; hypothetical protein complement(2276087..2278003) Corynebacterium diphtheriae NCTC 13129 2648940 NP_940502.1 CDS DIP2194 NC_002935.2 2278364 2279380 R Similar to Mycobacterium avium antigen 85-C precursor FbpC SW:A85C_MYCAV (O52972) (352 aa) fasta scores: E(): 3.7e-29, 34.32% id in 335 aa, and similar to but shorter than Corynebacterium glutamicum PS1 protein precursor Csp1 SW:CSP1_CORGL (Q01377) (657 aa) fasta scores: E(): 1.5e-28, 35.69% id in 297 aa; hypothetical protein complement(2278364..2279380) Corynebacterium diphtheriae NCTC 13129 2650335 NP_940503.1 CDS DIP2195 NC_002935.2 2279547 2281235 R Similar to Mycobacterium tuberculosis membrane protein Rv3805c or MT3912 or MTV026.10c TR:O53582 (EMBL:AL022076) (627 aa) fasta scores: E(): 4.1e-25, 36.36% id in 594 aa; hypothetical protein complement(2279547..2281235) Corynebacterium diphtheriae NCTC 13129 2649995 NP_940504.1 CDS DIP2196 NC_002935.2 2281244 2282221 R catalyzes the formation of decaprenylphosphoryl-5-phosphoribose from phosphoribose diphosphate and decaprenyl phosphate; phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase complement(2281244..2282221) Corynebacterium diphtheriae NCTC 13129 2649996 NP_940505.1 CDS DIP2197 NC_002935.2 2282218 2282712 R Similar to Mycobacterium tuberculosis hypothetical 17.2 kDa protein Rv3807c or MTV026.12 TR:O53584 (EMBL:AL022076) (165 aa) fasta scores: E(): 7.9e-29, 52.56% id in 156 aa, and to Streptomyces coelicolor integral membrane protein SC5G8.11 TR:Q9KZA3 (EMBL:AL353872) (169 aa) fasta scores: E(): 9.1e-17, 46.04% id in 139 aa; hypothetical protein complement(2282218..2282712) Corynebacterium diphtheriae NCTC 13129 2649997 NP_940506.1 CDS DIP2198 NC_002935.2 2282712 2284697 R Similar proteins from other actinomycetes eg. Mycobacterium tuberculosis hypothetical 71.5 kDa protein Rv3808c or MT3915 or MTV026.13c TR:O53585 (EMBL:AL022076) (637 aa) fasta scores: E(): 6.3e-88, 54.79% id in 657 aa; hypothetical protein complement(2282712..2284697) Corynebacterium diphtheriae NCTC 13129 2649998 NP_940507.1 CDS DIP2199 NC_002935.2 2284782 2285297 R Similar to Corynebacterium ammoniagenes Orf2 protein TR:Q9RHY7 (EMBL:AB003155) (163 aa) fasta scores: E(): 6.5e-14, 39.21% id in 153 aa, and to Escherichia coli hypothetical protein YbjG or B0841 SW:YBJG_ECOLI (P75806) (198 aa) fasta scores: E(): 1.9e-06, 32.69% id in 156 aa; hypothetical protein complement(2284782..2285297) Corynebacterium diphtheriae NCTC 13129 2649999 NP_940508.1 CDS gbsA NC_002935.2 2285338 2286915 R Similar to Bacillus subtilis betaine aldehyde dehydrogenase GbsA SW:DHAB_BACSU (P71016) (490 aa) fasta scores: E(): 2e-73, 54.63% id in 496 aa, and to Streptomyces coelicolor betaine aldehyde dehydrogenase GbsA TR:Q9K3J2 (EMBL:AL389898) (509 aa) fasta scores: E(): 3.2e-88, 55.75% id in 504 aa; betaine aldehyde dehydrogenase complement(2285338..2286915) Corynebacterium diphtheriae NCTC 13129 2650000 NP_940509.1 CDS betT NC_002935.2 2286982 2289207 R Similar to Escherichia coli high-affinity choline transport protein BetT or B0314 or Z0401 or ECS0360 SW:BETT_ECOLI (P17447) (677 aa) fasta scores: E(): 1.9e-118, 53.14% id in 668 aa, and to Erwinia amylovora high-affinity choline transport protein BetT TR:Q9F806 (EMBL:AF264948) (676 aa) fasta scores: E(): 2.5e-116, 51.98% id in 681 aa; high-affinity choline transport protein complement(2286982..2289207) Corynebacterium diphtheriae NCTC 13129 2650001 NP_940510.1 CDS betA NC_002935.2 2289560 2291272 D catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine; choline dehydrogenase 2289560..2291272 Corynebacterium diphtheriae NCTC 13129 2650002 NP_940511.1 CDS glf NC_002935.2 2291458 2292672 R Similar to Escherichia coli UDP-galactopyranose mutase Glf or B2036 SW:GLF_ECOLI (P37747) (367 aa) fasta scores: E(): 5.4e-48, 45.35% id in 377 aa, and to Mycobacterium tuberculosis UDP-galactopyranose mutase Glf or Rv3809c or MTV026.14 TR:O06934 (EMBL:U96128) (399 aa) fasta scores: E(): 1.3e-121, 76.09% id in 389 aa; UDP-galactopyranose mutase complement(2291458..2292672) Corynebacterium diphtheriae NCTC 13129 2650003 NP_940512.1 CDS DIP2204 NC_002935.2 2292835 2293263 R Similar to Mycobacterium tuberculosis hypothetical 23.9 kDa protein Rv0836c or MT0857 or MTV043.29c TR:O53848 (EMBL:AL022004) (217 aa) fasta scores: E(): 4.3e-13, 37.98% id in 129 aa; hypothetical protein complement(2292835..2293263) Corynebacterium diphtheriae NCTC 13129 2650004 NP_940513.1 CDS DIP2205 NC_002935.2 2293316 2294341 R Similar to Mycobacterium tuberculosis hypothetical 36.9 kDa protein Rv0837c or MTV043.30c TR:O53849 (EMBL:AL022004) (342 aa) fasta scores: E(): 7.7e-14, 30.38% id in 260 aa; DNA-binding protein complement(2293316..2294341) Corynebacterium diphtheriae NCTC 13129 2650005 NP_940514.1 CDS DIP2206 NC_002935.2 2294403 2294678 R nucleotide-binding protein complement(2294403..2294678) Corynebacterium diphtheriae NCTC 13129 2650006 NP_940515.1 CDS DIP2207 NC_002935.2 2295148 2296968 D Similar to Mycobacterium tuberculosis Csp or Rv3811 or MT3918 or MTV026.16 TR:O86334 (EMBL:Z97188) (539 aa) fasta scores: E(): 6.2e-33, 41.84% id in 411 aa, and to Streptomyces coelicolor secreted protein SCE34.21c TR:Q9KZK5 (EMBL:AL353862) (416 aa) fasta scores: E(): 5.6e-20, 28.74% id in 421 aa. Contains a proline/alanine rich region at residues 398-44, no present in homologues; hypothetical protein 2295148..2296968 Corynebacterium diphtheriae NCTC 13129 2650007 NP_940516.1 CDS DIP2208 NC_002935.2 2297077 2297805 R Similar to Escherichia coli hypothetical protein YgcI precursor or B2757 SW:YGCI_ECOLI (Q46898) (224 aa) fasta scores: E(): 0.02, 26.816% id in 179 aa; hypothetical protein complement(2297077..2297805) Corynebacterium diphtheriae NCTC 13129 2650008 NP_940517.1 CDS DIP2209 NC_002935.2 2297798 2298856 R Similar to Escherichia coli O157:H7 hypothetical 38.4 kDa protein ECS3612 TR:BAB37035 (EMBL:AP002562) (351 aa) fasta scores: E(): 8.7e-11, 33.333% id in 306 aa; hypothetical protein complement(2297798..2298856) Corynebacterium diphtheriae NCTC 13129 2650009 NP_940518.1 CDS DIP2210 NC_002935.2 2298912 2299496 R hypothetical protein complement(2298912..2299496) Corynebacterium diphtheriae NCTC 13129 2650010 NP_940519.1 CDS DIP2211 NC_002935.2 2299489 2301045 R hypothetical protein complement(2299489..2301045) Corynebacterium diphtheriae NCTC 13129 2650011 NP_940520.1 CDS DIP2212 NC_002935.2 2301411 2302097 D Similar to Escherichia coli hypothetical 22.3 kDa protein in iap-cysH intergenic region YgcH or B2756 SW:YGCH_ECOLI (Q46897) (199 aa) fasta scores: E(): 0.042, 24.873% id in 197 aa; hypothetical protein 2301411..2302097 Corynebacterium diphtheriae NCTC 13129 2650012 NP_940521.1 CDS DIP2213 NC_002935.2 2302097 2304727 D Similar to Escherichia coli hypothetical 100.5 kDa protein in iap-cysH intergenic region YgcB or B2761 SW:YGCB_ECOLI (P38036) (888 aa) fasta scores: E(): 1.1e-28, 28.827% id in 784 aa; helicase 2302097..2304727 Corynebacterium diphtheriae NCTC 13129 2650013 NP_940522.1 CDS DIP2214 NC_002935.2 2304729 2305688 D Similar to Escherichia coli hypothetical 33.2 kDa protein in iap-cysH intergenic region YgbT or B2755 SW:YGBT_ECOLI (Q46896) (305 aa) fasta scores: E(): 6.7e-17, 29.119% id in 261 aa; hypothetical protein 2304729..2305688 Corynebacterium diphtheriae NCTC 13129 2650014 NP_940523.1 CDS DIP2215 NC_002935.2 2305689 2306003 D Similar to Escherichia coli hypothetical 10.5 kDa protein in iap-cysH intergenic region YgbF or B2754 SW:YGBF_ECOLI (P45956) (94 aa) fasta scores: E(): 0.0075, 26.667% id in 90 aa; hypothetical protein 2305689..2306003 Corynebacterium diphtheriae NCTC 13129 2650015 NP_940524.1 CDS ssb2 NC_002935.2 2307893 2308408 D binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 2307893..2308408 Corynebacterium diphtheriae NCTC 13129 2650016 NP_940525.1 CDS DIP2217 NC_002935.2 2308427 2308660 D DNA-binding protein 2308427..2308660 Corynebacterium diphtheriae NCTC 13129 2650017 NP_940526.1 CDS DIP2218 NC_002935.2 2309127 2309804 D Similar to Mycobacteriophage TM4 gp6 TR:Q9ZX71 (EMBL:AF068845) (509 aa) fasta scores: E(): 1.4e-05, 32.903% id in 155 aa; hypothetical protein 2309127..2309804 Corynebacterium diphtheriae NCTC 13129 2650018 NP_940527.1 CDS DIP2219 NC_002935.2 2309879 2310220 D Some similarity to San Miguel sea lion virus RNA dependent RNA polymerase 3d TR:O09787 (EMBL:U52090) (149 aa) fasta scores: E(): 6.6, 31.776% id in 107 aa; hypothetical protein 2309879..2310220 Corynebacterium diphtheriae NCTC 13129 2650019 NP_940528.1 CDS DIP2220 NC_002935.2 2310210 2310485 D hypothetical protein 2310210..2310485 Corynebacterium diphtheriae NCTC 13129 2650020 NP_940529.1 CDS DIP2222 NC_002935.2 2310601 2310759 R hypothetical protein complement(2310601..2310759) Corynebacterium diphtheriae NCTC 13129 2650021 NP_940530.1 CDS DIP2223 NC_002935.2 2310948 2311757 R No significant database matches. Note: Contains a potential sortase anchor site (LGNTG) upstream of the C-terminal region transmembrane domain; surface-anchored protein complement(2310948..2311757) Corynebacterium diphtheriae NCTC 13129 2650022 NP_940531.1 CDS DIP2224 NC_002935.2 2311830 2312876 R Similar to Actinomyces naeslundii fimbriae-associated protein TR:O68213 (EMBL:AF019629) (365 aa) fasta scores: E(): 2.3e-33, 42.500% id in 280 aa, and to Staphylococcus aureus sortase SrtA TR:Q9S446 (EMBL:AF162687) (206 aa) fasta scores: E(): 0.0034, 26.115% id in 157 aa; fimbrial associated sortase-like protein complement(2311830..2312876) Corynebacterium diphtheriae NCTC 13129 2650023 NP_940532.1 CDS DIP2225 NC_002935.2 2312860 2313816 R Similar to Actinomyces naeslundii fimbria-associated protein TR:O68213 (EMBL:AF019629) (365 aa) fasta scores: E(): 3.2e-52, 51.254% id in 279 aa, and to Bifidobacterium longum NCC2705 sortase-like protein BL0676 SWALL:AAN24497 (EMBL:AE014690) (328 aa) fasta scores: E(): 3.6e-28, 34.02% id in 291 aa, and to Staphylococcus aureus subsp aureus Mu50 sortase SrtA TR:BAB58690 (EMBL:AP003365) (206 aa) fasta scores: E(): 0.027, 29.371% id in 143 aa; fimbrial associated sortase-like protein complement(2312860..2313816) Corynebacterium diphtheriae NCTC 13129 2650024 NP_940533.1 CDS DIP2226 NC_002935.2 2314006 2315673 R Similar to Actinomyces naeslundii fimbrial subunit type 2 precursor SW:FM2_ACTNA (P12616) (534 aa) fasta scores: E(): 1e-30, 38.276% id in 580 aa, and to Actinomyces viscosus fimbrial subunit type 1 precursor SW:FM1_ACTVI (P18477) (533 aa) fasta scores: E(): 7.4e-12, 29.856% id in 556 aa. Note: Contains a potential sortase anchor site (LPLTG) upstream of the C-terminal region transmembrane domain; surface-anchored fimbrial subunit complement(2314006..2315673) Corynebacterium diphtheriae NCTC 13129 2650025 NP_940534.1 CDS DIP2227 NC_002935.2 2315777 2319904 R Similar to Actinomyces naeslundii hypothetical 103.4 kDa protein TR:Q9EV17 (EMBL:AJ401093) (976 aa) fasta scores: E(): 0.0003, 29.146% id in 597 aa. Note: Contains a potential sortase anchor site (LPLTG) upstream of the C-terminal region transmembrane domain; surface-anchored fimbrial subunit complement(2315777..2319904) Corynebacterium diphtheriae NCTC 13129 2650026 NP_940535.1 CDS DIP2228 NC_002935.2 2320038 2320220 D hypothetical protein 2320038..2320220 Corynebacterium diphtheriae NCTC 13129 2650027 NP_940536.1 CDS DIP2233 NC_002935.2 2321459 2321896 D hypothetical protein 2321459..2321896 Corynebacterium diphtheriae NCTC 13129 2650029 NP_940537.1 CDS DIP2234 NC_002935.2 2322596 2322967 D hypothetical protein 2322596..2322967 Corynebacterium diphtheriae NCTC 13129 2650030 NP_940538.1 CDS glpK NC_002935.2 2323066 2324586 R Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase complement(2323066..2324586) Corynebacterium diphtheriae NCTC 13129 2650031 NP_940539.1 CDS glpF NC_002935.2 2324605 2325345 R Similar to Bacillus subtilis glycerol uptake facilitator protein GlpF SW:GLPF_BACSU (P18156) (274 aa) fasta scores: E(): 2.1e-23, 45.83% id in 240 aa; glycerol uptake facilitator protein complement(2324605..2325345) Corynebacterium diphtheriae NCTC 13129 2650032 NP_940540.1 CDS glpD NC_002935.2 2325345 2327078 R Similar to Mycobacterium leprae glycerol-3-phosphate dehydrogenase GlpD or ML0713 or L308_C1_179 SW:GLPD_MYCLE (P53435) (585 aa) fasta scores: E(): 5.7e-116, 55.35% id in 560 aa, and to Escherichia coli aerobic glycerol-3-phosphate dehydrogenase GlpD or GlyD or B3426 SW:GLPD_ECOLI (P13035) (501 aa) fasta scores: E(): 2.4e-38, 33.67% id in 493 aa; glycerol-3-phosphate dehydrogenase complement(2325345..2327078) Corynebacterium diphtheriae NCTC 13129 2650033 NP_940541.1 CDS DIP2238 NC_002935.2 2327266 2329098 R Similar to Mycobacterium tuberculosis acyltransferase Rv3816c or MTCY409.14 TR:O07807 (EMBL:Z97188) (259 aa) fasta scores: E(): 2.5e-34, 47.6% id in 250 aa, and to Brassica napus lysophosphatidic acid acyltransferase Act2 TR:Q9LLY4 (EMBL:AF111161) (344 aa) fasta scores: E(): 4.3e-06, 29.05% id in 148 aa; acyltransferase complement(2327266..2329098) Corynebacterium diphtheriae NCTC 13129 2650034 NP_940542.1 CDS DIP2239 NC_002935.2 2329111 2329938 R Similar to Mycobacterium tuberculosis hypothetical 28.5 kDa protein Rv3813c or MTCY409.17 TR:O07810 (EMBL:Z97188) (273 aa) fasta scores: E(): 4.2e-35, 41.69% id in 271 aa, and to Streptomyces coelicolor hypothetical 32.5 kDa protein SCD78.17c TR:Q9ZBY2 (EMBL:AL034355) (305 aa) fasta scores: E(): 2.3e-19, 34.29% id in 277 aa; hypothetical protein complement(2329111..2329938) Corynebacterium diphtheriae NCTC 13129 2650035 NP_940543.1 CDS serS NC_002935.2 2329968 2331227 R catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase complement(2329968..2331227) Corynebacterium diphtheriae NCTC 13129 2650036 NP_940544.1 CDS DIP2241 NC_002935.2 2331262 2332098 D Similar to Streptomyces coelicolor GntR-family transcriptional regulator SC7E4.28c TR:Q9K492 (EMBL:AL359214) (254 aa) fasta scores: E(): 7.3e-21, 34.82% id in 224 aa, and to Escherichia coli fatty acyl responsive regulator FarR or G30 or B0730 SW:FARR_ECOLI (P13669) (240 aa) fasta scores: E(): 6.4e-14, 30.93% id in 236 aa; GntR family transcriptional regulator 2331262..2332098 Corynebacterium diphtheriae NCTC 13129 2650037 NP_940545.1 CDS DIP2242 NC_002935.2 2332109 2333101 D Similar to, but shorter than, Mycobacterium tuberculosis hypothetical 47.0 kDa protein Rv3835 or MTCY01A6.34c TR:P96243 (EMBL:Z83864) (449 aa) fasta scores: E(): 6.4e-31, 34.83% id in 310 aa; hypothetical protein 2332109..2333101 Corynebacterium diphtheriae NCTC 13129 2650038 NP_940546.1 CDS DIP2243 NC_002935.2 2333108 2333455 D Similar to Mycobacterium tuberculosis hypothetical 15.0 kDa protein Rv3836 or MTCY01A6.33c TR:P96242 (EMBL:Z83864) (137 aa) fasta scores: E(): 2.5e-18, 47.78% id in 113 aa, and to Streptomyces coelicolor hypothetical 13.1 kDa protein SCD25.30 TR:Q9RKJ2 (EMBL:AL118514) (116 aa) fasta scores: E(): 5.9e-16, 46.08% id in 115 aa; hypothetical protein 2333108..2333455 Corynebacterium diphtheriae NCTC 13129 2650039 NP_940547.1 CDS DIP2244 NC_002935.2 2333530 2334777 D Similar to Mycoplasma fermentans similar to unrecognized orf in the mycobacterium tuberculosis genome sequence TR:Q9RFP6 (EMBL:AF179376) (373 aa) fasta scores: E(): 1.3e-25, 28.99% id in 369 aa, and to Mycobacterium tuberculosis hypothetical 48.1 kDa protein Rv3179 or MT3270 or MTV014.23 TR:O53329 (EMBL:AL021646) (429 aa) fasta scores: E(): 4e-15, 25.53% id in 423 aa; hypothetical protein 2333530..2334777 Corynebacterium diphtheriae NCTC 13129 2650040 NP_940548.1 CDS DIP2245 NC_002935.2 2334763 2335407 R Similar to Mycobacterium leprae phosphoglycerate mutase ML0079 TR:Q9CDC3 (EMBL:AL583917) (231 aa) fasta scores: E(): 4e-11, 33.64% id in 214 aa, and to Schizosaccharomyces pombe phosphoglycerate mutase Gpm1 or SPAC26F1.06 SW:PMGY_SCHPO (P36623) (211 aa) fasta scores: E(): 0.28, 24.4% id in 209 aa; phosphoglycerate mutase complement(2334763..2335407) Corynebacterium diphtheriae NCTC 13129 2650041 NP_940549.2 CDS pheA NC_002935.2 2335434 2336336 R catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; prephenate dehydratase complement(2335434..2336336) Corynebacterium diphtheriae NCTC 13129 2650042 NP_940550.1 CDS DIP2247 NC_002935.2 2336303 2337508 D Similar to Rhodococcus sp enantiomerase-selective amidase AmdA TR:Q53116 (EMBL:M74531) (462 aa) fasta scores: E(): 6.2e-15, 30.19% id in 414 aa, and to Mycobacterium smegmatis nicotinamidase/pyrazinamidase PzaA TR:Q9ZHK8 (EMBL:AF058285) (468 aa) fasta scores: E(): 6.4e-14, 30.55% id in 360 aa, and to Rhodococcus erythropolis amidase AmdA SW:AMID_RHOER (P22984) (520 aa) fasta scores: E(): 2.8e-11, 33.61% id in 238 aa; amidase 2336303..2337508 Corynebacterium diphtheriae NCTC 13129 2650043 NP_940551.1 CDS DIP2248 NC_002935.2 2337505 2338221 D Similar to Streptomyces coelicolor integral membrane protein SC10A9.14c TR:Q9AK90 (EMBL:AL583943) (275 aa) fasta scores: E(): 1.6e-17, 41.12% id in 248 aa; integral membrane protein 2337505..2338221 Corynebacterium diphtheriae NCTC 13129 2650044 NP_940552.1 CDS DIP2249 NC_002935.2 2338205 2340496 R Similar to Pseudomonas aeruginosa nitric-oxide reductase subunit B NorB or PA0524 SW:NORB_PSEAE (Q59647) (466 aa) fasta scores: E(): 4e-19, 28.54% id in 494 aa, and to Pseudomonas stutzeri nitric-oxide reductase subunit B NorB SW:NORB_PSEST (P98008) (473 aa) fasta scores: E(): 3.3e-17, 27.18% id in 493 aa; nitric-oxide reductase complement(2338205..2340496) Corynebacterium diphtheriae NCTC 13129 2650045 NP_940553.1 CDS DIP2250 NC_002935.2 2340708 2342003 D Region similar to many eg. Streptomyces coelicolor membrane protein SCBAC19G2.03c TR:CAC44513 (EMBL:AL596138) (397 aa) fasta scores: E(): 4.6e-19, 36.91% id in 409 aa, and to Staphylococcus aureus (strain N315), and SA2103 protein or SAV2310 TR:BAB58472 (EMBL:AP003136) (315 aa) fasta scores: E(): 4.5e-13, 31.07% id in 280 aa; hypothetical protein 2340708..2342003 Corynebacterium diphtheriae NCTC 13129 2650046 NP_940554.1 CDS DIP2251 NC_002935.2 2342131 2343621 R Similar to Vibrio cholerae sodium/alanine symporter Vc0784 TR:Q9KTV3 (EMBL:AE004164) (516 aa) fasta scores: E(): 1.7e-83, 47.34% id in 509 aa, and to Bacillus PS3 sodium/proton-dependent alanine carrier protein Acp SW:ALCP_BACP3 (P30145) (445 aa) fasta scores: E(): 3.9e-58, 46.25% id in 454 aa; sodium/alanine symporter complement(2342131..2343621) Corynebacterium diphtheriae NCTC 13129 2650047 NP_940555.1 CDS DIP2252 NC_002935.2 2343812 2345605 D Similar to Bacillus subtilis hypothetical 72.2 kDa protein YrhL TR:O05402 (EMBL:U93874) (634 aa) fasta scores: E(): 5.9e-41, 31.37% id in 631 aa, and to Streptomyces coelicolor possible integral membrane protein SC8G12.07c TR:Q9KYZ8 (EMBL:AL355753) (418 aa) fasta scores: E(): 2.5e-32, 37.7% id in 419 aa; hypothetical protein 2343812..2345605 Corynebacterium diphtheriae NCTC 13129 2650048 NP_940556.1 CDS DIP2253 NC_002935.2 2345667 2346533 R Similar to Streptomyces coelicolor hypothetical 34.5 kDa protein SCBAC25E3.11c TR:CAC44698 (EMBL:AL596251) (321 aa) fasta scores: E(): 1.1e-27, 36.17% id in 293 aa; hypothetical protein complement(2345667..2346533) Corynebacterium diphtheriae NCTC 13129 2650049 NP_940557.1 CDS DIP2254 NC_002935.2 2346584 2347267 R Similar to Mycobacterium tuberculosis hypothetical 29.9 kDa protein GlpQ1 or Rv3842c or MT3950 or MTCY01A6.27 TR:P96236 (EMBL:Z83864) (274 aa) fasta scores: E(): 1e-08, 36.84% id in 247 aa, and to Streptomyces coelicolor phosphodiesterase 2SCG4.06 TR:Q9K3Q8 (EMBL:AL360034) (227 aa) fasta scores: E(): 1.2e-08, 28.5% id in 228 aa; hypothetical protein complement(2346584..2347267) Corynebacterium diphtheriae NCTC 13129 2650050 NP_940558.1 CDS ldh NC_002935.2 2347413 2348369 R Converts (S)-lactate and NAD(+) to pyruvate and NADH; L-lactate dehydrogenase complement(2347413..2348369) Corynebacterium diphtheriae NCTC 13129 2650051 NP_940559.1 CDS DIP2256 NC_002935.2 2348729 2349454 R Similar to many eg. Mycobacterium tuberculosis hypothetical 25.9 kDa protein Rv1593c or MT1629 or MTCY336.11 TR:O06597 (EMBL:Z95586) (236 aa) fasta scores: E(): 1.2e-20, 37.28% id in 228 aa. Note possible alternative translational start site; hypothetical protein complement(2348729..2349454) Corynebacterium diphtheriae NCTC 13129 2650052 NP_940560.1 CDS nadA NC_002935.2 2349511 2350428 D 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 2349511..2350428 Corynebacterium diphtheriae NCTC 13129 2650053 NP_940561.1 CDS nadB NC_002935.2 2350425 2351654 D Member of a large family of including Sulfolobus solfataricus aspartate oxidase NadB or SSO0997 TR:Q97ZC5 (EMBL:AE006719) (487 aa) fasta scores: E(): 1.4e-18, 36.79% id in 405 aa, and to Streptomyces coelicolor L-aspartate oxidase SCE94.33c TR:Q9X8N8 (EMBL:AL049628) (580 aa) fasta scores: E(): 2.1e-15, 39.6% id in 409 aa; aspartate oxidase 2350425..2351654 Corynebacterium diphtheriae NCTC 13129 2650054 NP_940562.1 CDS nadC NC_002935.2 2351642 2352469 D Similar to Mycobacterium tuberculosis nicotinate-nucleotide pyrophosphorylase [carboxylating] NadC or Rv1596 or MT1632 or MTCY336.08c SWALL:NADC_MYCTU (SWALL:O06594) (285 aa) fasta scores: E(): 2.1e-43, 51.09% id in 274 aa, and to Salmonella typhimurium nicotinate-nucleotide pyrophosphorylase [carboxylating] NadC or STM0145 SWALL:NADC_SALTY (SWALL:P30012) (296 aa) fasta scores: E(): 1.6e-34, 41.17% id in 272 aa; nicotinate-nucleotide pyrophosphorylase 2351642..2352469 Corynebacterium diphtheriae NCTC 13129 2650055 NP_940563.1 CDS msrA NC_002935.2 2352676 2353338 R this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A complement(2352676..2353338) Corynebacterium diphtheriae NCTC 13129 2650056 NP_940564.1 CDS sodA NC_002935.2 2353492 2354091 D Similar to Corynebacterium melassecola manganese superoxide dismutase SodA SWALL:BAB62412 (EMBL:AF236111) (200 aa) fasta scores: E(): 1.7e-67, 84.26% id in 197 aa. Previously described as Corynebacterium diphtheriae superoxide dismutase [Mn] SodA or Sod SWALL:SODM_CORDI (SWALL:P42821) (162 aa) fasta scores: E(): 1.5e-62, 97.56% id in 164 aa (note difference in translational start); manganese superoxide dismutase 2353492..2354091 Corynebacterium diphtheriae NCTC 13129 2650057 NP_940565.1 CDS DIP2262 NC_002935.2 2354340 2354876 D Similar to Neisseria meningitidis oxidoreductase NMA0666 SWALL:Q9JVV3 (EMBL:AL162753) (188 aa) fasta scores: E(): 5.4e-42, 62.7% id in 185 aa, and to Pseudomonas putida chromate reductase ChrR SWALL:AAK56853 (EMBL:AF375642) (186 aa) fasta scores: E(): 9.1e-28, 45.19% id in 177 aa, and to Arabidopsis thaliana NADPH:quinone oxidoreductase Nqr SWALL:Q9XFI5 (EMBL:AF145234) (196 aa) fasta scores: E(): 1.7e-11, 36.7% id in 158 aa; oxidoreductase 2354340..2354876 Corynebacterium diphtheriae NCTC 13129 2650058 NP_940566.1 CDS DIP2263 NC_002935.2 2354873 2356225 R Similar to Mycobacterium tuberculosis membrane protein Rv2181 or MTV021.14 SWALL:O53515 (EMBL:AL021957) (427 aa) fasta scores: E(): 1.3e-33, 34.86% id in 370 aa; hypothetical protein complement(2354873..2356225) Corynebacterium diphtheriae NCTC 13129 2650059 NP_940567.1 CDS DIP2264 NC_002935.2 2356239 2357810 R Similar to Mycobacterium tuberculosis hypothetical 123.1 kDa protein Rv1251c or MT1290 or MTV006.23c SWALL:O50466 (EMBL:AL021006) (1139 aa) fasta scores: E(): 1.6, 26.47% id in 544 aa; hypothetical protein complement(2356239..2357810) Corynebacterium diphtheriae NCTC 13129 2650060 NP_940568.1 CDS DIP2265 NC_002935.2 2357845 2358555 D Similar to Mycobacterium tuberculosis hypothetical 23.8 kDa protein Rv3850 or MTCY01A6.18C SWALL:P96227 (EMBL:Z83864) (218 aa) fasta scores: E(): 7.9e-15, 34.1% id in 217 aa; hypothetical protein 2357845..2358555 Corynebacterium diphtheriae NCTC 13129 2650061 NP_940569.1 CDS DIP2266 NC_002935.2 2358677 2358994 D Similar to Streptomyces coelicolor Lsr2-like protein SCD25.12c SWALL:Q9RKK8 (EMBL:AL118514) (105 aa) fasta scores: E(): 1.1e-08, 39.04% id in 105 aa, and to Mycobacterium leprae Lsr2 protein precursor or ML0234 SWALL:LSR2_MYCLE (SWALL:P24094) (112 aa) fasta scores: E(): 2.4, 26.95% id in 115 aa; hypothetical protein 2358677..2358994 Corynebacterium diphtheriae NCTC 13129 2650062 NP_940570.1 CDS DIP2267 NC_002935.2 2359054 2359692 R Similar to Streptomyces coelicolor two component system DNA binding response regulator SC10A9.12 SWALL:Q9AK92 (EMBL:AL583943) (211 aa) fasta scores: E(): 7.7e-38, 59.24% id in 211 aa, and to Corynebacterium diphtheriae response regulator ChrA (DIP2327) SWALL:Q9RPE9 (EMBL:AF161327) (199 aa) fasta scores: E(): 2.1e-21, 49.76% id in 209 aa; two component system response regulator protein complement(2359054..2359692) Corynebacterium diphtheriae NCTC 13129 2650063 NP_940571.1 CDS DIP2268 NC_002935.2 2359774 2361153 R Similar to Streptomyces coelicolor two component system histidine kinase SC10A9.11 SWALL:Q9AK93 (EMBL:AL583943) (404 aa) fasta scores: E(): 7.7e-36, 37.15% id in 401 aa, and to Corynebacterium diphtheriae histidine kinase ChrS (DIP2326) SWALL:Q9RPF0 (EMBL:AF161327) (417 aa) fasta scores: E(): 8.2e-25, 31.17% id in 401 aa; two component system histidine kinase complement(2359774..2361153) Corynebacterium diphtheriae NCTC 13129 2650064 NP_940572.1 CDS DIP2269 NC_002935.2 2361176 2361622 D hypothetical protein 2361176..2361622 Corynebacterium diphtheriae NCTC 13129 2650065 NP_940573.1 CDS uhpT NC_002935.2 2361757 2363166 D cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate; sugar phosphate antiporter 2361757..2363166 Corynebacterium diphtheriae NCTC 13129 2650066 NP_940574.1 CDS DIP2271 NC_002935.2 2363229 2363381 R Similar to Streptomyces coelicolor hypothetical 8.0 kDa protein SCH69.22c SWALL:Q9XA12 (EMBL:AL079308) (69 aa) fasta scores: E(): 1.3e-05, 40% id in 50 aa; hypothetical protein complement(2363229..2363381) Corynebacterium diphtheriae NCTC 13129 2650067 NP_940575.1 CDS DIP2272 NC_002935.2 2363388 2364209 R Similar to Clostridium acetobutylicum sortase CAC0204 TR:AAK78186 (EMBL:AE007533) (194 aa) fasta scores: E(): 2.6e-06, 30.872% id in 149 aa, and weakly similar to Actinomyces naeslundii fimbria-associated protein TR:O68213 (EMBL:AF019629) (365 aa) fasta scores: E(): 0.25, 32.941% id in 85 aa, and to Streptococcus pneumoniae TIGR4 sortase, SP0466 TR:AAK74626 (EMBL:AE007358) (279 aa) fasta scores: E(): 5.3, 25.000% id in 144 aa; sortase complement(2363388..2364209) Corynebacterium diphtheriae NCTC 13129 2650068 NP_940576.1 CDS DIP2273 NC_002935.2 2364341 2365648 D functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; inner membrane protein translocase component YidC 2364341..2365648 Corynebacterium diphtheriae NCTC 13129 2650069 NP_940577.1 CDS DIP2274 NC_002935.2 2365515 2366141 R Similar to many eg. Streptomyces coelicolor transcriptional regulator SCD6.32c SWALL:Q9KZX2 (EMBL:AL353815) (200 aa) fasta scores: E(): 8.4e-15, 36.72% id in 177 aa; TetR family transcriptional regulator complement(2365515..2366141) Corynebacterium diphtheriae NCTC 13129 2650070 NP_940578.1 CDS DIP2275 NC_002935.2 2366430 2366693 R Similar to Mycobacterium tuberculosis hypothetical 10.3 kDa protein Rv1861 or MTCY359.12c SWALL:P95154 (EMBL:Z83859) (101 aa) fasta scores: E(): 1.6e-10, 47.72% id in 88 aa, and to Escherichia coli transglycosylase associated protein YmgE or Tag or B1195 SWALL:TAG1_ECOLI (SWALL:P76011) (84 aa) fasta scores: E(): 2.5e-05, 38.82% id in 85 aa; hypothetical protein complement(2366430..2366693) Corynebacterium diphtheriae NCTC 13129 2650071 NP_940579.1 CDS DIP2276 NC_002935.2 2366976 2367878 R Similar to many including predicted universal stress proteins eg. Mycobacterium tuberculosis hypothetical 30.9 kDa protein Rv2005c or MT2061 or MTCY39.12 SWALL:YK05_MYCTU (SWALL:Q10851) (295 aa) fasta scores: E(): 1.7e-32, 40.87% id in 296 aa, and to Mycobacterium tuberculosis CDC1551 universal stress protein family MT2698 SWALL:AAK47014 (EMBL:AE007102) (297 aa) fasta scores: E(): 1.7e-30, 36.73% id in 294 aa; hypothetical protein complement(2366976..2367878) Corynebacterium diphtheriae NCTC 13129 2650072 NP_940580.1 CDS DIP2277 NC_002935.2 2368117 2369166 D Similar to hypothetical proteins and proposed ribosomal pseudouridine synthases eg. Mycobacterium tuberculosis hypothetical 33.3 kDa protein Rv3300c or MT3399 or MTCI418A.02c SWALL:O07166 (EMBL:Z96070) (305 aa) fasta scores: E(): 6.3e-23, 45.74% id in 247 aa, and to Streptomyces coelicolor ribosomal pseudouridine synthase SCI41.08 SWALL:Q9RJ76 (EMBL:AL132648) (324 aa) fasta scores: E(): 1.9e-22, 40.69% id in 317 aa; hypothetical protein 2368117..2369166 Corynebacterium diphtheriae NCTC 13129 2650073 NP_940581.1 CDS DIP2278 NC_002935.2 2375291 2376304 R No significant database matches. Lies downstream of a ABC transporter ATP-binding subunit; integral membrane protein complement(2375291..2376304) Corynebacterium diphtheriae NCTC 13129 2650077 NP_940582.1 CDS DIP2279 NC_002935.2 2376306 2377175 R Similar to many eg. Bacillus halodurans ABC transporter BH3493 SWALL:Q9K777 (EMBL:AP001519) (283 aa) fasta scores: E(): 3.8e-18, 33.97% id in 209 aa, and to Bacillus subtilis hypothetical ABC transporter ATP-binding protein YhcG SWALL:YHCG_BACSU (SWALL:P54591) (232 aa) fasta scores: E(): 4.1e-12, 31.01% id in 216 aa; ABC transporter ATP-binding protein complement(2376306..2377175) Corynebacterium diphtheriae NCTC 13129 2650078 NP_940583.1 CDS DIP2280 NC_002935.2 2377172 2377558 R Similar to many eg. Bacillus halodurans transcriptional regulator BH3492 SWALL:Q9K778 (EMBL:AP001519) (129 aa) fasta scores: E(): 6.6e-15, 43.36% id in 113 aa; GntR family transcriptional regulator complement(2377172..2377558) Corynebacterium diphtheriae NCTC 13129 2650079 NP_940584.1 CDS DIP2281 NC_002935.2 2377787 2379163 D Similar to Streptomyces coelicolor hypothetical 44.0 kDa protein SC4G6.31c SWALL:Q9S2S7 (EMBL:AL096884) (403 aa) fasta scores: E(): 4.6e-09, 25.49% id in 459 aa; hypothetical protein 2377787..2379163 Corynebacterium diphtheriae NCTC 13129 2650080 NP_940585.1 CDS DIP2282 NC_002935.2 2379236 2380000 R Similar to Mycobacterium tuberculosis 35 kDa protein Rv2744c or MT2815 or MTV002.09c SWALL:35KD_MYCTU (SWALL:P31511) (270 aa) fasta scores: E(): 8.4e-29, 45.52% id in 257 aa; hypothetical protein complement(2379236..2380000) Corynebacterium diphtheriae NCTC 13129 2650081 NP_940586.1 CDS DIP2284 NC_002935.2 2380171 2380554 R Similar to Streptomyces coelicolor thioredoxin TrxA2 SWALL:Q9RD25 (EMBL:AL133422) (134 aa) fasta scores: E(): 1.7e-23, 52.89% id in 121 aa, and to Escherichia coli thioredoxin 2 TrxC or B2582 or Z3867 or ECS3448 SWALL:THI2_ECOLI (SWALL:P33636) (139 aa) fasta scores: E(): 5.9e-11, 38% id in 100 aa; thioredoxin complement(2380171..2380554) Corynebacterium diphtheriae NCTC 13129 2650082 NP_940587.1 CDS DIP2285 NC_002935.2 2380762 2380971 D Similar to Streptomyces coelicolor metal associated protein SCG20A.25 SWALL:Q9K3L5 (EMBL:AL360055) (77 aa) fasta scores: E(): 1.3e-05, 45.9% id in 61 aa, and to Helicobacter felis cop associated protein CopP SWALL:COPP_HELFE (SWALL:O32620) (66 aa) fasta scores: E(): 0.0074, 36.92% id in 65 aa; cation transport protein 2380762..2380971 Corynebacterium diphtheriae NCTC 13129 2650083 NP_940588.1 CDS DIP2286 NC_002935.2 2381127 2383358 D Similar to Streptomyces coelicolor probable cation-transporting P-type ATPase SCC57A.02 SWALL:Q9RDJ4 (EMBL:AL136519) (760 aa) fasta scores: E(): 7e-146, 60.21% id in 744 aa, and to Rhizobium meliloti copper-transporting ATPase ActP SWALL:ATCU_RHIME (SWALL:Q9X5X3) (827 aa) fasta scores: E(): 1.3e-84, 42.12% id in 762 aa; cation-transporting P-type ATPase 2381127..2383358 Corynebacterium diphtheriae NCTC 13129 2650084 NP_940589.1 CDS DIP2287 NC_002935.2 2383456 2384781 D Similar to Deinococcus radiodurans sugar transporter, DRA0271 SWALL:Q9RYN9 (EMBL:AE001863) (454 aa) fasta scores: E(): 9.2e-54, 41.12% id in 445 aa, and to Pseudomonas putida 4-hydroxybenzoate transporter PcaK SWALL:PCAK_PSEPU (SWALL:Q51955) (448 aa) fasta scores: E(): 1.8e-25, 30.4% id in 398 aa; integral membrane transport protein 2383456..2384781 Corynebacterium diphtheriae NCTC 13129 2650085 NP_940590.1 CDS dnaB NC_002935.2 2384785 2386305 R unwinds double stranded DNA; replicative DNA helicase complement(2384785..2386305) Corynebacterium diphtheriae NCTC 13129 2648662 NP_940591.1 CDS rplI NC_002935.2 2386879 2387331 R in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 complement(2386879..2387331) Corynebacterium diphtheriae NCTC 13129 2649123 NP_940592.1 CDS ssb1 NC_002935.2 2387462 2388043 R binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein complement(2387462..2388043) Corynebacterium diphtheriae NCTC 13129 2649124 NP_940593.2 CDS rpsF NC_002935.2 2388168 2388455 R binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 complement(2388168..2388455) Corynebacterium diphtheriae NCTC 13129 2649125 NP_940594.1 CDS DIP2292 NC_002935.2 2388650 2388829 R hypothetical protein complement(2388650..2388829) Corynebacterium diphtheriae NCTC 13129 2649126 NP_940595.1 CDS DIP2293 NC_002935.2 2388829 2390400 R Similar to Streptomyces coelicolor transmembrane protein SCH24.24 SWALL:Q9X8T8 (EMBL:AL049826) (502 aa) fasta scores: E(): 7.8e-37, 36.2% id in 453 aa; hypothetical protein complement(2388829..2390400) Corynebacterium diphtheriae NCTC 13129 2649127 NP_940596.1 CDS DIP2294 NC_002935.2 2390445 2392625 R Similar to Mycobacterium smegmatis penicillin-binding protein 1 PonA SWALL:Q9F9V7 (EMBL:AF165523) (715 aa) fasta scores: E(): 4.1e-105, 51.23% id in 689 aa, and to Bacillus subtilis penicillin-binding protein 1A/1B PonA SWALL:PBPA_BACSU (SWALL:P39793) (914 aa) fasta scores: E(): 1.4e-32, 29.44% id in 720 aa; penicillin-binding protein complement(2390445..2392625) Corynebacterium diphtheriae NCTC 13129 2649128 NP_940597.1 CDS DIP2295 NC_002935.2 2392713 2393075 R Similar to Mycobacterium tuberculosis hypothetical 15.0 kDa protein Rv0049 or MT0055 or MTCY21D4.12 SWALL:Y049_MYCTU (SWALL:P71706) (137 aa) fasta scores: E(): 1e-15, 47.52% id in 101 aa; hypothetical protein complement(2392713..2393075) Corynebacterium diphtheriae NCTC 13129 2649129 NP_940598.1 CDS DIP2296 NC_002935.2 2393194 2393646 D Similar to Mycobacterium tuberculosis CDC1551 transcriptional regulator, MarR family MT0048 SWALL:AAK44270 (EMBL:AE006918) (208 aa) fasta scores: E(): 1.9e-07, 34.72% id in 144 aa, and to Streptomyces coelicolor MarR-family transcriptional regulator SC6D11.20 SWALL:Q9L135 (EMBL:AL158061) (155 aa) fasta scores: E(): 4.7e-05, 33.05% id in 121 aa; MarR family transcriptional regulator 2393194..2393646 Corynebacterium diphtheriae NCTC 13129 2649130 NP_940599.1 CDS DIP2297 NC_002935.2 2393656 2394621 D Similar to Mycobacterium tuberculosis hypothetical 31.9 kDa protein Rv2319c or MT2382 or MTCY3G12.15 SWALL:YN19_MYCTU (SWALL:P71893) (292 aa) fasta scores: E(): 4.3e-21, 28% id in 300 aa; hypothetical protein 2393656..2394621 Corynebacterium diphtheriae NCTC 13129 2649131 NP_940600.1 CDS DIP2298 NC_002935.2 2394633 2395304 D Similar to Bacillus subtilis hypothetical oxidoreductase YoxD SWALL:YOXD_BACSU (SWALL:P14802) (238 aa) fasta scores: E(): 2.2e-09, 28.57% id in 231 aa, and to Rhizobium sp short-chain type dehydrogenase/reductase SWALL:Y4EK_RHISN (SWALL:P55434) (248 aa) fasta scores: E(): 2.3e-09, 30% id in 210 aa; short chain dehydrogenase 2394633..2395304 Corynebacterium diphtheriae NCTC 13129 2649132 NP_940601.1 CDS DIP2299 NC_002935.2 2395316 2395789 D hypothetical protein 2395316..2395789 Corynebacterium diphtheriae NCTC 13129 2650407 NP_940602.1 CDS DIP2300 NC_002935.2 2395856 2397301 R Regions similar to Pyrococcus abyssi hypothetical 32.8 kDa protein PAB0790 SWALL:Q9UZG6 (EMBL:AJ248286) (287 aa) fasta scores: E(): 1.4e-09, 27.45% id in 306 aa, and to Thiobacillus ferrooxidans ATP-dependent DNA helicase RecG SWALL:RECG_THIFE (SWALL:O50224) (652 aa) fasta scores: E(): 1.9e-07, 30.04% id in 223 aa; DNA-binding protein complement(2395856..2397301) Corynebacterium diphtheriae NCTC 13129 2650408 NP_940603.1 CDS DIP2301 NC_002935.2 2397459 2398397 R Similar to Staphylococcus aureus (strain N315) conserved hypothetical protein SA2481 or SAV2689 SWALL:Q99QV2 (EMBL:AP003138) (318 aa) fasta scores: E(): 3.6e-25, 34.68% id in 297 aa; hypothetical protein complement(2397459..2398397) Corynebacterium diphtheriae NCTC 13129 2650409 NP_940604.1 CDS DIP2302 NC_002935.2 2398584 2399222 D Similar to Streptomyces coelicolor integral membrane protein SC4A9.02c SWALL:Q9L1W0 (EMBL:AL138668) (231 aa) fasta scores: E(): 8.7e-31, 41.5% id in 200 aa; hypothetical protein 2398584..2399222 Corynebacterium diphtheriae NCTC 13129 2650410 NP_940605.1 CDS DIP2303 NC_002935.2 2399360 2399845 R Similar to Haemophilus ducreyi fine tangled pili major subunit FtpA SWALL:FTPA_HAEDU (SWALL:Q47953) (189 aa) fasta scores: E(): 3.5e-23, 46.83% id in 158 aa, and to Escherichia coli DNA protection during starvation protein Dps or Pexb or Vtm or B0812 or Z1034 or ECS0890 SWALL:DPS_ECOLI (SWALL:P27430) (166 aa) fasta scores: E(): 1.6e-14, 38.31% id in 154 aa; DNA protection during starvation protein complement(2399360..2399845) Corynebacterium diphtheriae NCTC 13129 2650411 NP_940606.1 CDS DIP2304 NC_002935.2 2399933 2400787 D Similar to Streptomyces coelicolor DNA repair hydrolase SCC80.11c SWALL:Q9F308 (EMBL:AL442143) (306 aa) fasta scores: E(): 1.1e-52, 53.22% id in 295 aa, and to Escherichia coli formamidopyrimidine-DNA glycosylase MutM or Fpg or B3635 SWALL:FPG_ECOLI (SWALL:P05523) (269 aa) fasta scores: E(): 1.2e-12, 29.21% id in 243 aa; DNA repair glycosylase 2399933..2400787 Corynebacterium diphtheriae NCTC 13129 2650412 NP_940607.1 CDS DIP2305 NC_002935.2 2400809 2402317 D Similar to Mycobacterium tuberculosis hypothetical 46.9 kDa protein Rv3433c or MT3539 or MTCY77.05c SWALL:YY33_MYCTU (SWALL:O06250) (473 aa) fasta scores: E(): 1.8e-30, 41.96% id in 510 aa; hypothetical protein 2400809..2402317 Corynebacterium diphtheriae NCTC 13129 2650413 NP_940608.1 CDS DIP2306 NC_002935.2 2402330 2403466 R Similar to Saccharopolyspora erythraea lysozyme SWALL:O33985 (EMBL:U82823) (241 aa) fasta scores: E(): 1.3e-23, 36.9% id in 233 aa, and to Clostridium acetobutylicum autolytic lysozyme Lyc or CAC0554 SWALL:LYC_CLOAB (SWALL:P34020) (324 aa) fasta scores: E(): 4.7e-10, 28.27% id in 191 aa; hydrolase complement(2402330..2403466) Corynebacterium diphtheriae NCTC 13129 2650414 NP_940609.1 CDS DIP2307 NC_002935.2 2403526 2404152 R hypothetical protein complement(2403526..2404152) Corynebacterium diphtheriae NCTC 13129 2650415 NP_940610.1 CDS DIP2308 NC_002935.2 2404326 2405387 R Similar to proteins associated with plasmid replication-partitioning eg. Plesiomonas shigelloides hypothetical SoJ-like protein Soj SWALL:Q9RLE7 (EMBL:AJ249644) (182 aa) fasta scores: E(): 1.8e-05, 29.31% id in 191 aa, and to Pseudomonas fluorescens ParA protein SWALL:Q9RLI2 (EMBL:AJ250853) (394 aa) fasta scores: E(): 3.4e-05, 28.77% id in 212 aa, and to Thermus thermophilus partitioning protein ParA/Soj SWALL:Q9LCY1 (EMBL:AJ277593) (248 aa) fasta scores: E(): 0.00017, 31.63% id in 196 aa, and to Lactobacillus reuteri replication-associated protein A RepA SWALL:O52364 (EMBL:AF036766) (295 aa) fasta scores: E(): 0.00042, 28.91% id in 211 aa; hypothetical protein complement(2404326..2405387) Corynebacterium diphtheriae NCTC 13129 2650416 NP_940611.1 CDS DIP2309 NC_002935.2 2405722 2406678 R DNA-binding protein complement(2405722..2406678) Corynebacterium diphtheriae NCTC 13129 2649133 NP_940612.1 CDS DIP2310 NC_002935.2 2406782 2407360 R Similar to N-terminal half of Pyrococcus abyssi hypothetical 48.8 kDa protein Pab1002 SWALL:Q9UYK0 (EMBL:AJ248287) (428 aa) fasta scores: E(): 0.081, 30.05% id in 193 aa; hypothetical protein complement(2406782..2407360) Corynebacterium diphtheriae NCTC 13129 2649134 NP_940613.1 CDS DIP2311 NC_002935.2 2407563 2409290 R Similar to Deinococcus radiodurans ATP-dependent DNA helicase RecG-related protein DR2199 SWALL:Q9RSC6 (EMBL:AE002053) (596 aa) fasta scores: E(): 1.1e-09, 27.17% id in 574 aa, and to Thiobacillus ferrooxidans ATP-dependent DNA helicase RecG SWALL:RECG_THIFE (SWALL:O50224) (652 aa) fasta scores: E(): 7.7e-05, 33.08% id in 133 aa; hypothetical protein complement(2407563..2409290) Corynebacterium diphtheriae NCTC 13129 2649135 NP_940614.1 CDS DIP2312 NC_002935.2 2409373 2412573 R Similar to Pasteurella haemolytica HsdR SWALL:P95512 (EMBL:U46781) (1055 aa) fasta scores: E(): 1.4e-61, 34.88% id in 1055 aa; type I restriction/modification system protein complement(2409373..2412573) Corynebacterium diphtheriae NCTC 13129 2649136 NP_940615.1 CDS DIP2313 NC_002935.2 2412566 2413810 R Similar to Lactococcus lactis HsdS subunit SWALL:O68173 (EMBL:AF013596) (395 aa) fasta scores: E(): 2.7e-13, 33.72% id in 172 aa, and to Streptococcus thermophilus type I S-subunit protein HsdS SWALL:O52188 (EMBL:AF027167) (412 aa) fasta scores: E(): 1.6e-12, 27.84% id in 334 aa; type I restriction/modification system DNA specificity protein complement(2412566..2413810) Corynebacterium diphtheriae NCTC 13129 2649137 NP_940616.1 CDS DIP2314 NC_002935.2 2413807 2415414 R Similar to Klebsiella pneumoniae HsdM SWALL:O34139 (EMBL:U93843) (539 aa) fasta scores: E(): 6.2e-66, 45.37% id in 551 aa, and to Pasteurella multocida HsdM or PM1537 SWALL:Q9CKR9 (EMBL:AE006190) (568 aa) fasta scores: E(): 2e-51, 44.38% id in 561 aa; type I restriction/modification system DNA methylase complement(2413807..2415414) Corynebacterium diphtheriae NCTC 13129 2649138 NP_940617.1 CDS DIP2315 NC_002935.2 2415495 2417453 R DNA-binding protein complement(2415495..2417453) Corynebacterium diphtheriae NCTC 13129 2649139 NP_940618.1 CDS DIP2317 NC_002935.2 2417717 2418952 R Similar to Arthrobacter keyseri hypothetical 45.9 kDa protein TnpX SWALL:Q9AGM1 (EMBL:AF331043) (421 aa) fasta scores: E(): 9.4e-26, 33.86% id in 378 aa, and to Agrobacterium tumefaciens STRC58 AGR_PAT_51p SWALL:AAK90413 (EMBL:AE007876) (393 aa) fasta scores: E(): 1.9e-19, 29.67% id in 374 aa; DNA-binding protein complement(2417717..2418952) Corynebacterium diphtheriae NCTC 13129 2649140 NP_940619.1 CDS DIP2318 NC_002935.2 2419180 2420880 R Similar to Vibrio cholerae hypothetical protein VCA0786 SWALL:Q9KLF8 (EMBL:AE004407) (549 aa) fasta scores: E(): 1.3e-63, 42.28% id in 570 aa, and to Aeropyrum pernix hypothetical 61.1 kDa protein APE1810 ape1810 SWALL:Q9YAY5 (EMBL:AP000062) (558 aa) fasta scores: E(): 1.5e-39, 33.5% id in 570 aa; hypothetical protein complement(2419180..2420880) Corynebacterium diphtheriae NCTC 13129 2649141 NP_940620.1 CDS DIP2319 NC_002935.2 2420959 2421561 R Similar to Mycobacterium paratuberculosis copper zinc superoxide dismutase SodC SWALL:Q9AGW2 (EMBL:AF326234) (226 aa) fasta scores: E(): 1.4e-18, 41.36% id in 220 aa, and to Caulobacter crescentus superoxide dismutase [Cu-Zn] precursor SodC or CC1579 SWALL:SODC_CAUCR (SWALL:P20379) (174 aa) fasta scores: E(): 2e-12, 35.13% id in 185 aa; copper zinc superoxide dismutase complement(2420959..2421561) Corynebacterium diphtheriae NCTC 13129 2649142 NP_940621.1 CDS leuS NC_002935.2 2421946 2424828 R leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase complement(2421946..2424828) Corynebacterium diphtheriae NCTC 13129 2649143 NP_940622.1 CDS DIP2321 NC_002935.2 2424897 2425046 R Doubtful CDS. No significant database matches; hypothetical protein complement(2424897..2425046) Corynebacterium diphtheriae NCTC 13129 2649144 NP_940623.1 CDS DIP2322 NC_002935.2 2425110 2425832 R hypothetical protein complement(2425110..2425832) Corynebacterium diphtheriae NCTC 13129 2649145 NP_940624.1 CDS DIP2323 NC_002935.2 2425889 2426554 R Similar to Streptomyces coelicolor ABC transport system ATP-binding protein SC10A9.09c SWALL:Q9AK95 (EMBL:AL583943) (251 aa) fasta scores: E(): 4.7e-31, 51.35% id in 222 aa; ABC transporter ATP-binding protein complement(2425889..2426554) Corynebacterium diphtheriae NCTC 13129 2649146 NP_940625.1 CDS DIP2324 NC_002935.2 2426551 2427585 R Similar to Streptomyces coelicolor ABC transport system transmembrane protein SC10A9.10c SWALL:Q9AK94 (EMBL:AL583943) (379 aa) fasta scores: E(): 4.3e-17, 38.94% id in 380 aa. Lies alongside a ABC transporter ATP-binding subunit; ABC transporter inner membrane protein complement(2426551..2427585) Corynebacterium diphtheriae NCTC 13129 2649147 NP_940626.1 CDS DIP2325 NC_002935.2 2427721 2430360 R No significant database matches. Note: Contains a potential sortase anchor site (LAETG) upstream of the C-terminal region transmembrane domain. Also similar to DIP0439, DIP1724, DIP0442 and DIP0443; surface-anchored protein complement(2427721..2430360) Corynebacterium diphtheriae NCTC 13129 2649148 NP_940627.1 CDS chrS NC_002935.2 2430452 2431705 D Previously sequenced and described as Corynebacterium diphtheriae histidine kinase ChrS SWALL:Q9RPF0 (EMBL:AF161327) (417 aa) fasta scores: E(): 4e-136, 88.72% id in 417 aa. Similar to many eg. Streptomyces reticuli histidine autokinase SenS SWALL:Q9RIM1 (EMBL:Y14336) (398 aa) fasta scores: E(): 1.6e-21, 35.28% id in 411 aa; two-component system histidine kinase ChrS 2430452..2431705 Corynebacterium diphtheriae NCTC 13129 2649149 NP_940628.1 CDS chrA NC_002935.2 2431702 2432301 D Previously sequenced and described as Corynebacterium diphtheriae response regulator ChrA SWALL:Q9RPE9 (EMBL:AF161327) (199 aa) fasta scores: E(): 2.7e-67, 98.49% id in 199 aa. Similar to many eg. Streptomyces reticuli response regulatory protein SenR SWALL:Q9RIM0 (EMBL:Y14336) (217 aa) fasta scores: E(): 1.5e-28, 49.51% id in 204 aa; two-component response regulator ChrA 2431702..2432301 Corynebacterium diphtheriae NCTC 13129 2649150 NP_940629.1 CDS DIP2328 NC_002935.2 2432298 2432843 R Similar to Clostridium acetobutylicum uncharacterized conserved membrane protein, similar to Mdr CAC0829 SWALL:AAK78805 (EMBL:AE007599) (308 aa) fasta scores: E(): 0.0003, 25.88% id in 170 aa, and has region in common with Enterococcus faecium protein VanZ SWALL:VANZ_ENTFC (SWALL:Q06242) (161 aa) fasta scores: E(): 0.19, 29.16% id in 96 aa; integral membrane protein complement(2432298..2432843) Corynebacterium diphtheriae NCTC 13129 2649151 NP_940630.1 CDS DIP2329 NC_002935.2 2432940 2434841 R Weak but full length similarity to many eg. Clostridium acetobutylicum uncharacterized conserved membrane protein, YhgE B.subtilis ortholog CAC3589 SWALL:AAK81512 (EMBL:AE007855) (783 aa) fasta scores: E(): 1.6e-16, 23.62% id in 766 aa; hypothetical protein complement(2432940..2434841) Corynebacterium diphtheriae NCTC 13129 2649152 NP_940631.1 CDS DIP2330 NC_002935.2 2435213 2436271 D No significant database matches. Lies in DNA region of low GC content.; hypothetical protein 2435213..2436271 Corynebacterium diphtheriae NCTC 13129 2649153 NP_940632.1 CDS DIP2331 NC_002935.2 2436460 2437851 D Similar to Deinococcus radiodurans succinate-semialdehyde dehydrogenase [NADP+] SsdA or DRA0343 SWALL:GABD_DEIRA (SWALL:O32507) (477 aa) fasta scores: E(): 1.2e-81, 49.44% id in 453 aa, and to Streptomyces coelicolor aldehyde dehydrogenase 2SCG58.04 SWALL:Q9FCA9 (EMBL:AL391017) (461 aa) fasta scores: E(): 4.1e-65, 42.57% id in 458 aa, and to Ustilago maydis indole-3-acetaldehyde dehydrogenase Iad1 SWALL:Q92460 (EMBL:U74468) (497 aa) fasta scores: E(): 1.6e-48, 37.04% id in 467 aa; aldehyde dehydrogenase 2436460..2437851 Corynebacterium diphtheriae NCTC 13129 2649154 NP_940633.1 CDS DIP2332 NC_002935.2 2438019 2438813 D Similar to Streptomyces coelicolor hypothetical 17.6 kDa protein SCJ21.18C SWALL:Q9S1Y9 (EMBL:AL109747) (170 aa) fasta scores: E(): 3e-29, 56.97% id in 172 aa, and to Escherichia coli unknown pentitol II, A component SgaA or B4195 or Z5804 or ECS5171 SWALL:PTXA_ECOLI (SWALL:P39303) (154 aa) fasta scores: E(): 1.3e-12, 39.82% id in 113 aa; phosphotransferase system protein 2438019..2438813 Corynebacterium diphtheriae NCTC 13129 2649155 NP_940634.1 CDS ulaA NC_002935.2 2438839 2440401 D membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 2438839..2440401 Corynebacterium diphtheriae NCTC 13129 2649156 NP_940635.1 CDS DIP2334 NC_002935.2 2440685 2441680 D with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase; dihydroxyacetone kinase subunit DhaK 2440685..2441680 Corynebacterium diphtheriae NCTC 13129 2649157 NP_940636.1 CDS DIP2335 NC_002935.2 2441684 2442325 D Similar to Selenomonas ruminantium subspruminantium dihydroxyacetone kinase Dhak2 SWALL:AAG14892 (EMBL:AF297121) (207 aa) fasta scores: E(): 6.6e-25, 48.51% id in 202 aa, and to Escherichia coli protein YcgS or B1199 SWALL:YCGS_ECOLI (SWALL:P76014) (210 aa) fasta scores: E(): 2e-22, 43.12% id in 211 aa. Lies downstream of a Dhak1 homologue; dihydroxyacetone kinase sununit 2441684..2442325 Corynebacterium diphtheriae NCTC 13129 2649158 NP_940637.1 CDS DIP2336 NC_002935.2 2442322 2442990 D Similar to but longer than a family of hypothetical proteins eg. Deinococcus radiodurans conserved hypothetical protein DRB0052 SWALL:Q9RZR3 (EMBL:AE001826) (133 aa) fasta scores: E(): 8.8e-10, 43.75% id in 128 aa, and to Staphylococcus aureus (strain N315) hypothetical protein SA0607 or SAV0652 SWALL:Q99VW9 (EMBL:AP003131) (120 aa) fasta scores: E(): 1.3e-09, 42.73% id in 117 aa; hypothetical protein 2442322..2442990 Corynebacterium diphtheriae NCTC 13129 2649159 NP_940638.1 CDS DIP2337 NC_002935.2 2443176 2444495 D Similar to Lactococcus lactis abortive phage resistance protein AbilI SWALL:O06042 (EMBL:U94520) (458 aa) fasta scores: E(): 7.4e-08, 26.39% id in 466 aa. Lies in DNA region of low GC content.; phage resistance protein 2443176..2444495 Corynebacterium diphtheriae NCTC 13129 2649160 NP_940639.1 CDS DIP2338 NC_002935.2 2444518 2445123 D hypothetical protein 2444518..2445123 Corynebacterium diphtheriae NCTC 13129 2649161 NP_940640.1 CDS DIP2339 NC_002935.2 2445460 2446680 R Similar to a family of proteins members of which are part of the antigen 85 complex responsible for the high affinity of mycobacteria for fibronectin. Similar to Corynebacterium ammoniagenes surface layer protein A SlpA SWALL:BAB62413 (EMBL:AB055224) (358 aa) fasta scores: E(): 2.6e-18, 31.23% id in 317 aa, and to Mycobacterium tuberculosis antigen 85-A precursor FbpA or Mpt44 or Rv3804c or MT3911 or MTV026.09c SWALL:A85A_MYCTU (SWALL:P17944) (338 aa) fasta scores: E(): 4.4e-18, 32.14% id in 280 aa, and to Corynebacterium glutamicum PS1 protein precursor Csp1 SWALL:CSP1_CORGL (SWALL:Q01377) (657 aa) fasta scores: E(): 5.2e-16, 30.02% id in 403 aa; major secreted protein complement(2445460..2446680) Corynebacterium diphtheriae NCTC 13129 2649162 NP_940641.1 CDS DIP2340 NC_002935.2 2446717 2447712 D Similar to members of a family of nucleoside hydrolases eg. Mycobacterium tuberculosis nucleoside hydrolase IunH or Rv3393 or MTV004.51 SWALL:O50418 (EMBL:AL009198) (308 aa) fasta scores: E(): 7.6e-27, 36.07% id in 316 aa, and to Crithidia fasciculata inosine-uridine preferring nucleoside hydrolase IunH SWALL:IUNH_CRIFA (SWALL:Q27546) (314 aa) fasta scores: E(): 2.7e-14, 28.07% id in 317 aa; nucleoside hydrolase 2446717..2447712 Corynebacterium diphtheriae NCTC 13129 2649163 NP_940642.1 CDS DIP2341 NC_002935.2 2447808 2448566 D Similar to Escherichia coli O157:H7 transporter ECS3800 SWALL:BAB37223 (EMBL:AP002563) (192 aa) fasta scores: E(): 6e-15, 30.16% id in 179 aa. Lies alongside a ABC transporter ATP-binding subunit; integral membrane transport protein 2447808..2448566 Corynebacterium diphtheriae NCTC 13129 2649164 NP_940643.1 CDS DIP2342 NC_002935.2 2448572 2449264 D Similar to Streptomyces coelicolor integral membrane transport protein SCE87.11 SWALL:Q9RKC7 (EMBL:AL132674) (253 aa) fasta scores: E(): 0.082, 26.54% id in 226 aa; integral membrane transport protein 2448572..2449264 Corynebacterium diphtheriae NCTC 13129 2649165 NP_940644.1 CDS DIP2343 NC_002935.2 2449283 2450449 D Similar to Streptomyces coelicolor ABC transporter ATP-binding subunit SCC53.15 SWALL:Q9KXJ6 (EMBL:AL357591) (563 aa) fasta scores: E(): 1.9e-05, 26.87% id in 439 aa, and to Methanobacterium thermoautotrophicum cobalt transport ATP-binding protein CbiO SWALL:Q50801 (EMBL:X94292) (277 aa) fasta scores: E(): 0.00012, 30.4% id in 171 aa; ABC transporter ATP-binding protein 2449283..2450449 Corynebacterium diphtheriae NCTC 13129 2649166 NP_940645.1 CDS DIP2344 NC_002935.2 2450460 2451242 R Weakly similar to many eg. Escherichia coli unknown protein from 2d-page YeaD or B1780 SWALL:UP08_ECOLI (SWALL:P39173) (294 aa) fasta scores: E(): 0.00013, 28.74% id in 247 aa; hypothetical protein complement(2450460..2451242) Corynebacterium diphtheriae NCTC 13129 2649167 NP_940646.1 CDS DIP2345 NC_002935.2 2451284 2451928 D hypothetical protein 2451284..2451928 Corynebacterium diphtheriae NCTC 13129 2649168 NP_940647.1 CDS DIP2346 NC_002935.2 2451936 2453429 R Similar to proteins from streptococci eg. Streptococcus pneumoniae hypothetical protein Sp0341 SWALL:AAK74515 (EMBL:AE007346) (494 aa) fasta scores: E(): 3.6e-101, 51.82% id in 492 aa, and to Streptococcus pyogenes hypothetical protein Spy1343 SWALL:Q99Z89 (EMBL:AE006572) (518 aa) fasta scores: E(): 8.2e-100, 50.9% id in 495 aa; hypothetical protein complement(2451936..2453429) Corynebacterium diphtheriae NCTC 13129 2649169 NP_940648.1 CDS DIP2347 NC_002935.2 2453493 2453762 R Weakly similar to Rhizobium meliloti hypothetical protein Smc02732 r02394 or smc02732 TR:CAC46973 (EMBL:AL591790) (134 aa) fasta scores: E(): 1.4, 32.92% id in 82 aa; hypothetical protein complement(2453493..2453762) Corynebacterium diphtheriae NCTC 13129 2649170 NP_940649.1 CDS DIP2348 NC_002935.2 2453759 2454376 R Weakly similar to Mycobacterium tuberculosis hypothetical 15.7 kDa protein Rv2011c precursor or MT2066 or MTCY39.06 SW:YK11_MYCTU (Q10846) (143 aa) fasta scores: E(): 5.2, 26.66% id in 135 aa; hypothetical protein complement(2453759..2454376) Corynebacterium diphtheriae NCTC 13129 2649171 NP_940650.1 CDS DIP2349 NC_002935.2 2454544 2455788 R Similar to Treponema pallidum glutamate/aspartate transporter, tp0555 TR:O83566 (EMBL:AE001231) (396 aa) fasta scores: E(): 2.9e-33, 33.86% id in 375 aa; integral membrane transport protein complement(2454544..2455788) Corynebacterium diphtheriae NCTC 13129 2649172 NP_940651.1 CDS DIP2350 NC_002935.2 2455876 2456448 D integral membrane protein 2455876..2456448 Corynebacterium diphtheriae NCTC 13129 2649173 NP_940652.1 CDS trpB1 NC_002935.2 2456701 2458032 D catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 2456701..2458032 Corynebacterium diphtheriae NCTC 13129 2649174 NP_940653.1 CDS trpE NC_002935.2 2458035 2459588 D with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 2458035..2459588 Corynebacterium diphtheriae NCTC 13129 2649175 NP_940654.1 CDS trpG NC_002935.2 2459588 2460232 D TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity; anthranilate synthase component II 2459588..2460232 Corynebacterium diphtheriae NCTC 13129 2649176 NP_940655.1 CDS trpD NC_002935.2 2460247 2461272 D Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase 2460247..2461272 Corynebacterium diphtheriae NCTC 13129 2649177 NP_940656.1 CDS trpC1 NC_002935.2 2461262 2462719 D monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase 2461262..2462719 Corynebacterium diphtheriae NCTC 13129 2649178 NP_940657.1 CDS DIP2356 NC_002935.2 2462780 2463157 D Similar to Neisseria meningitidis membrane protein NMA0754 TR:Q9JVP6 (EMBL:AL162754) (119 aa) fasta scores: E(): 3.9e-14, 47.67% id in 86 aa, and to Escherichia coli, and hypothetical protein YanB or B0468 or Z0585 or ECS0521 SW:YBAN_ECOLI (P45808) (125 aa) fasta scores: E(): 1.2e-10, 37.83% id in 111 aa; hypothetical protein 2462780..2463157 Corynebacterium diphtheriae NCTC 13129 2649179 NP_940658.1 CDS panC NC_002935.2 2463154 2464014 D Similar to Mycobacterium tuberculosis pantoate--beta-alanine ligase PanC or Rv3602c or MT3707 or MTCY07H7B.20 SW:PANC_MYCTU (O06280) (309 aa) fasta scores: E(): 1e-42, 47.65% id in 277 aa, and to Corynebacterium glutamicum pantoate--beta-alanine ligase PanC SW:PANC_CORGL (Q9X713) (279 aa) fasta scores: E(): 1.8e-32, 42.65% id in 279 aa; pantoate--beta-alanine ligase 2463154..2464014 Corynebacterium diphtheriae NCTC 13129 2649180 NP_940659.1 CDS panB NC_002935.2 2464011 2464802 R catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase complement(2464011..2464802) Corynebacterium diphtheriae NCTC 13129 2649181 NP_940660.1 CDS trpB2 NC_002935.2 2465139 2466365 D catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 2465139..2466365 Corynebacterium diphtheriae NCTC 13129 2649182 NP_940661.1 CDS trpA NC_002935.2 2466370 2467206 D catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 2466370..2467206 Corynebacterium diphtheriae NCTC 13129 2649183 NP_940662.1 CDS DIP2362 NC_002935.2 2467213 2467623 D Similar to Mycobacterium smegmatis Rieske iron-sulfur protein QcrA TR:Q9XBV4 (EMBL:AF155062) (138 aa) fasta scores: E(): 1.7e-11, 40.9% id in 132 aa, and to Streptomyces coelicolor iron-sulphur protein SCI51.03 TR:Q9S237 (EMBL:AL109848) (131 aa) fasta scores: E(): 3.8e-10, 35.15% id in 128 aa; iron-sulfur protein 2467213..2467623 Corynebacterium diphtheriae NCTC 13129 2649184 NP_940663.1 CDS DIP2363 NC_002935.2 2467644 2468612 D Similar to Streptomyces coelicolor transmembrane protein SC4B5.06 TR:Q9ZBW2 (EMBL:AL034443) (345 aa) fasta scores: E(): 1.3e-52, 52.73% id in 311 aa; integral membrane protein 2467644..2468612 Corynebacterium diphtheriae NCTC 13129 2649185 NP_940664.1 CDS DIP2364 NC_002935.2 2468609 2468935 D hypothetical protein 2468609..2468935 Corynebacterium diphtheriae NCTC 13129 2649186 NP_940665.1 CDS DIP2365 NC_002935.2 2469062 2469427 R Similar to Bacillus subtilis branched-chain amino acid transport protein AzlD SW:AZLD_BACSU (O07923) (110 aa) fasta scores: E(): 8.2e-05, 36.27% id in 102 aa; integral membrane amino acid transport protein complement(2469062..2469427) Corynebacterium diphtheriae NCTC 13129 2649187 NP_940666.1 CDS DIP2366 NC_002935.2 2469436 2470167 R Similar to Bacillus subtilis branched-chain amino acid transport protein AzlC SW:AZLC_BACSU (O07942) (254 aa) fasta scores: E(): 4.2e-14, 29.38% id in 211 aa; integral membrane amino acid transport protein complement(2469436..2470167) Corynebacterium diphtheriae NCTC 13129 2649188 NP_940667.1 CDS DIP2367 NC_002935.2 2470168 2470764 R Similar to Mycobacterium tuberculosis hypothetical 21.8 kDa protein Rv0038 or MT0043 or MTCY10h4.38 SW:Y038_MYCTU (P71608) (202 aa) fasta scores: E(): 4.4e-28, 43.64% id in 181 aa; hypothetical protein complement(2470168..2470764) Corynebacterium diphtheriae NCTC 13129 2649189 NP_940668.1 CDS DIP2368 NC_002935.2 2470765 2472252 R Similar to a family of proteins from both prokaryotes and eukaryotes and including poly A polymerases and tRNA nucleotidyl transferases. Since prokaryotes don't generally have poly A tailed mRNAs the prokaryotic proteins are likely to be RNA nucleotidyl transferases. Similar to Mycobacterium tuberculosis PcnA or Rv3907c or MTCY15F10.04 TR:O05438 (EMBL:Z94121) (480 aa) fasta scores: E(): 3.5e-119, 64.61% id in 472 aa, and to Streptomyces coelicolor RNA nucleotidyltransferase SCH24.18 TR:Q9X8T2 (EMBL:AL049826) (483 aa) fasta scores: E(): 1.3e-103, 58.06% id in 465 aa. Similar to Escherichia coli tRNA nucleotidyltransferase Cca or B3056 SW:CCA_ECOLI (P06961) blast scores: E(): 2e-20, score: 250 30% id; tRNA nucleotidyltransferase complement(2470765..2472252) Corynebacterium diphtheriae NCTC 13129 2649190 NP_940669.1 CDS DIP2369 NC_002935.2 2472392 2473264 D Extensive (but not full length) similarity to Mycobacterium tuberculosis hypothetical 27.1 kDa protein Rv3908 or MTCY15f10.03C TR:O05437 (EMBL:Z94121) (248 aa) fasta scores: E(): 2.3e-25, 47.39% id in 211 aa. Has a hydrophilic N-terminal region.; hypothetical protein 2472392..2473264 Corynebacterium diphtheriae NCTC 13129 2649191 NP_940670.1 CDS DIP2370 NC_002935.2 2473261 2475975 D Weak but full length similarity to Mycobacterium tuberculosis hypothetical 83.9 kDa protein Rv3909 or MTCY15F10.02c TR:O05436 (EMBL:Z94121) (802 aa) fasta scores: E(): 8.4e-10, 25.54% id in 916 aa; hypothetical protein 2473261..2475975 Corynebacterium diphtheriae NCTC 13129 2649192 NP_940671.1 CDS DIP2371 NC_002935.2 2476084 2479413 D Similar to Mycobacterium tuberculosis hypothetical 123.6 kDa protein Rv3910 or MTCY15F10.01c or MTV028.01 TR:O05435 (EMBL:Z94121) (1184 aa) fasta scores: E(): 1.1e-83, 35.58% id in 1200 aa, and to Rhizobium tropici virulence factor MviN homolog SW:MVIN_RHITR (O05467) (533 aa) fasta scores: E(): 5.7e-15, 23.87% id in 553 aa; hypothetical protein 2476084..2479413 Corynebacterium diphtheriae NCTC 13129 2649193 NP_940672.1 CDS DIP2372 NC_002935.2 2479572 2480174 D Similar to Pseudomonas fluorescens alternative sigma factor AlgU TR:AAK94006 (EMBL:AF399758) (193 aa) fasta scores: E(): 8.1e-12, 30.1% id in 186 aa, and to Pseudomonas aeruginosa RNA polymerase sigma-H factor AlgU or AlgT or PA0762 SW:RPSH_PSEAE (Q06198) (193 aa) fasta scores: E(): 1.8e-11, 29.03% id in 186 aa; RNA polymerase sigma factor 2479572..2480174 Corynebacterium diphtheriae NCTC 13129 2649194 NP_940673.1 CDS trxB NC_002935.2 2480310 2481254 D Similar to Mycobacterium smegmatis thioredoxin reductase TrxB SW:TRXB_MYCSM (O30973) (311 aa) fasta scores: E(): 3.1e-72, 64.82% id in 307 aa; thioredoxin reductase 2480310..2481254 Corynebacterium diphtheriae NCTC 13129 2649195 NP_940674.1 CDS trxA NC_002935.2 2481269 2481592 D Similar to Mycobacterium smegmatis thioredoxin TrxA SW:THIO_MYCSM (O30974) (112 aa) fasta scores: E(): 5.8e-18, 48.14% id in 108 aa; thioredoxin 2481269..2481592 Corynebacterium diphtheriae NCTC 13129 2649196 NP_940675.1 CDS DIP2375 NC_002935.2 2481613 2482821 D Similar to Mycobacterium tuberculosis hydrolase CwlM or Rv3915 or MTV028.06 TR:O53593 (EMBL:AL021426) (406 aa) fasta scores: E(): 5.4e-78, 52.38% id in 399 aa, and to Bacillus subtilis N-acetylmuramoyl-L-alanine amidase CwlB precursor or LytC SW:CWLB_BACSU (Q02114) (496 aa) fasta scores: E(): 2.8e-07, 25.62% id in 199 aa; hydrolase 2481613..2482821 Corynebacterium diphtheriae NCTC 13129 2649197 NP_940676.1 CDS parB NC_002935.2 2482889 2483992 R Similar to Mycobacterium tuberculosis probable chromosome partitioning protein ParB or Rv3917c or MT4036 or MTV028.08c SW:PARB_MYCTU (O53595) (344 aa) fasta scores: E(): 7.4e-47, 54.93% id in 375 aa, and to Streptomyces coelicolor chromosome partitioning protein ParB TR:Q9RFM2 (EMBL:AF187159) (368 aa) fasta scores: E(): 3.2e-43, 47.69% id in 369 aa; chromosome partitioning protein complement(2482889..2483992) Corynebacterium diphtheriae NCTC 13129 2649198 NP_940677.1 CDS parA NC_002935.2 2483999 2485015 R Similar to Streptomyces coelicolor chromosome partitioning protein ParA TR:Q9RFM1 (EMBL:AF187159) (357 aa) fasta scores: E(): 2.5e-64, 63.6% id in 294 aa, and to Bacillus subtilis sporulation initiation inhibitor protein Soj SW:SOJ_BACSU (P37522) (253 aa) fasta scores: E(): 2.8e-45, 54.15% id in 253 aa; chromosome partitioning protein complement(2483999..2485015) Corynebacterium diphtheriae NCTC 13129 2649199 NP_940678.1 CDS gidB NC_002935.2 2485137 2485808 R glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB complement(2485137..2485808) Corynebacterium diphtheriae NCTC 13129 2649200 NP_940679.1 CDS DIP2379 NC_002935.2 2485931 2486884 R functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; inner membrane protein translocase component YidC complement(2485931..2486884) Corynebacterium diphtheriae NCTC 13129 2649201 NP_940680.1 CDS rnpA NC_002935.2 2487177 2487536 R protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P complement(2487177..2487536) Corynebacterium diphtheriae NCTC 13129 2649203 NP_940681.1 CDS rpmH NC_002935.2 2487568 2487711 R in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 complement(2487568..2487711) Corynebacterium diphtheriae NCTC 13129 2649204 DIPt01 tRNA tRNA-Ile NC_002935.2 11818 11891 D tRNA-Ile 11818..11891 Corynebacterium diphtheriae NCTC 13129 2650418 DIPt02 tRNA tRNA-Ala NC_002935.2 11904 11976 D tRNA-Ala 11904..11976 Corynebacterium diphtheriae NCTC 13129 2650419 DIPt03 tRNA tRNA-Ile NC_002935.2 19068 19141 D tRNA-Ile 19068..19141 Corynebacterium diphtheriae NCTC 13129 2649061 DIPt04 tRNA tRNA-Ala NC_002935.2 19154 19226 D tRNA-Ala 19154..19226 Corynebacterium diphtheriae NCTC 13129 2649062 DIPt05 tRNA tRNA-Ala NC_002935.2 20221 20293 D tRNA-Ala 20221..20293 Corynebacterium diphtheriae NCTC 13129 2650600 DIPt06 tRNA tRNA-Leu NC_002935.2 53080 53163 D tRNA-Leu 53080..53163 Corynebacterium diphtheriae NCTC 13129 2650566 DIPt07 tRNA tRNA-Ser NC_002935.2 150357 150441 D tRNA-Ser 150357..150441 Corynebacterium diphtheriae NCTC 13129 2649045 DIPt08 tRNA tRNA-Ser NC_002935.2 151769 151857 D tRNA-Ser 151769..151857 Corynebacterium diphtheriae NCTC 13129 2648855 DIPt09 tRNA tRNA-Arg NC_002935.2 151905 151977 D tRNA-Arg 151905..151977 Corynebacterium diphtheriae NCTC 13129 2648856 DIPt10 tRNA tRNA-Arg NC_002935.2 154077 154149 D tRNA-Arg 154077..154149 Corynebacterium diphtheriae NCTC 13129 2650554 DIPt11 tRNA tRNA-Arg NC_002935.2 190709 190788 D tRNA-Arg 190709..190788 Corynebacterium diphtheriae NCTC 13129 2648507 DIPt12 tRNA tRNA-Ser NC_002935.2 210284 210371 D tRNA-Ser 210284..210371 Corynebacterium diphtheriae NCTC 13129 2650635 DIPt13 tRNA tRNA-Ser NC_002935.2 219137 219222 R tRNA-Ser complement(219137..219222) Corynebacterium diphtheriae NCTC 13129 2649497 DIPt14 tRNA tRNA-Pro NC_002935.2 264680 264753 R tRNA-Pro complement(264680..264753) Corynebacterium diphtheriae NCTC 13129 2648775 DIPt15 tRNA tRNA-Thr NC_002935.2 305408 305480 D tRNA-Thr 305408..305480 Corynebacterium diphtheriae NCTC 13129 2650455 DIPt16 tRNA tRNA-Tyr NC_002935.2 394779 394860 D tRNA-Tyr 394779..394860 Corynebacterium diphtheriae NCTC 13129 2650503 DIPt17 tRNA tRNA-Thr NC_002935.2 395053 395125 D tRNA-Thr 395053..395125 Corynebacterium diphtheriae NCTC 13129 2650504 DIPt18 tRNA tRNA-Met NC_002935.2 395164 395235 D tRNA-Met 395164..395235 Corynebacterium diphtheriae NCTC 13129 2650505 DIPt19 tRNA tRNA-Trp NC_002935.2 395264 395336 D tRNA-Trp 395264..395336 Corynebacterium diphtheriae NCTC 13129 2650506 DIPt20 tRNA tRNA-Met NC_002935.2 710975 711048 D tRNA-Met 710975..711048 Corynebacterium diphtheriae NCTC 13129 2649316 DIPt21 tRNA tRNA-Arg NC_002935.2 795540 795612 R tRNA-Arg complement(795540..795612) Corynebacterium diphtheriae NCTC 13129 2650535 DIPt22 tRNA tRNA-Gln NC_002935.2 882605 882676 D tRNA-Gln 882605..882676 Corynebacterium diphtheriae NCTC 13129 2648594 DIPt23 tRNA tRNA-Leu NC_002935.2 895059 895132 D tRNA-Leu 895059..895132 Corynebacterium diphtheriae NCTC 13129 2649960 DIPt24 tRNA tRNA-Arg NC_002935.2 1008521 1008593 R tRNA-Arg complement(1008521..1008593) Corynebacterium diphtheriae NCTC 13129 2648614 DIPt25 tRNA tRNA-Gln NC_002935.2 1100709 1100780 D tRNA-Gln 1100709..1100780 Corynebacterium diphtheriae NCTC 13129 2650856 DIPt26 tRNA tRNA-Glu NC_002935.2 1100814 1100886 D tRNA-Glu 1100814..1100886 Corynebacterium diphtheriae NCTC 13129 2650857 DIPt27 tRNA tRNA-Glu NC_002935.2 1106131 1106203 D tRNA-Glu 1106131..1106203 Corynebacterium diphtheriae NCTC 13129 2649923 DIPt28 tRNA tRNA-Leu NC_002935.2 1129683 1129756 R tRNA-Leu complement(1129683..1129756) Corynebacterium diphtheriae NCTC 13129 2648810 DIPt29 tRNA tRNA-Pro NC_002935.2 1201374 1201447 D tRNA-Pro 1201374..1201447 Corynebacterium diphtheriae NCTC 13129 2649756 DIPt30 tRNA tRNA-Leu NC_002935.2 1273184 1273269 D tRNA-Leu 1273184..1273269 Corynebacterium diphtheriae NCTC 13129 2649820 DIPt31 tRNA tRNA-Val NC_002935.2 1409586 1409657 R tRNA-Val complement(1409586..1409657) Corynebacterium diphtheriae NCTC 13129 2649460 DIPt32 tRNA tRNA-Gly NC_002935.2 1409946 1410018 D tRNA-Gly 1409946..1410018 Corynebacterium diphtheriae NCTC 13129 2649461 DIPt33 tRNA tRNA-Val NC_002935.2 1410036 1410107 D tRNA-Val 1410036..1410107 Corynebacterium diphtheriae NCTC 13129 2649462 DIPt34 tRNA tRNA-Gly NC_002935.2 1410141 1410213 D tRNA-Gly 1410141..1410213 Corynebacterium diphtheriae NCTC 13129 2649463 DIPt35 tRNA tRNA-Cys NC_002935.2 1410252 1410322 D tRNA-Cys 1410252..1410322 Corynebacterium diphtheriae NCTC 13129 2649464 DIPt36 tRNA tRNA-Val NC_002935.2 1410330 1410401 D tRNA-Val 1410330..1410401 Corynebacterium diphtheriae NCTC 13129 2649465 DIPt37 tRNA tRNA-Gly NC_002935.2 1410435 1410507 D tRNA-Gly 1410435..1410507 Corynebacterium diphtheriae NCTC 13129 2649466 DIPt38 tRNA tRNA-Val NC_002935.2 1722455 1722527 R tRNA-Val complement(1722455..1722527) Corynebacterium diphtheriae NCTC 13129 2650276 DIPt39 tRNA tRNA-Asn NC_002935.2 1734689 1734761 R tRNA-Asn complement(1734689..1734761) Corynebacterium diphtheriae NCTC 13129 2650288 DIPt40 tRNA tRNA-Met NC_002935.2 1734940 1735013 D tRNA-Met 1734940..1735013 Corynebacterium diphtheriae NCTC 13129 2650289 DIPt41 tRNA tRNA-Pro NC_002935.2 1842304 1842377 R tRNA-Pro complement(1842304..1842377) Corynebacterium diphtheriae NCTC 13129 2649419 DIPt42 tRNA tRNA-Gly NC_002935.2 1842721 1842792 R tRNA-Gly complement(1842721..1842792) Corynebacterium diphtheriae NCTC 13129 2649420 DIPt43 tRNA tRNA-Arg NC_002935.2 1861148 1861221 R tRNA-Arg complement(1861148..1861221) Corynebacterium diphtheriae NCTC 13129 2649438 DIPt44 tRNA tRNA-His NC_002935.2 1863910 1863982 D tRNA-His 1863910..1863982 Corynebacterium diphtheriae NCTC 13129 2649442 DIPt45 tRNA tRNA-Lys NC_002935.2 1866327 1866399 D tRNA-Lys 1866327..1866399 Corynebacterium diphtheriae NCTC 13129 2649446 DIPt46 tRNA tRNA-Leu NC_002935.2 1893990 1894071 R tRNA-Leu complement(1893990..1894071) Corynebacterium diphtheriae NCTC 13129 2649222 DIPt47 tRNA tRNA-Ala NC_002935.2 1923546 1923618 R tRNA-Ala complement(1923546..1923618) Corynebacterium diphtheriae NCTC 13129 2649255 DIPt48 tRNA tRNA-Phe NC_002935.2 1942583 1942655 R tRNA-Phe complement(1942583..1942655) Corynebacterium diphtheriae NCTC 13129 2649272 DIPt49 tRNA tRNA-Asp NC_002935.2 1942678 1942751 R tRNA-Asp complement(1942678..1942751) Corynebacterium diphtheriae NCTC 13129 2648661 DIPt50 tRNA tRNA-Asp NC_002935.2 1944118 1944191 R tRNA-Asp complement(1944118..1944191) Corynebacterium diphtheriae NCTC 13129 2648941 DIPt51 tRNA tRNA-Glu NC_002935.2 1944221 1944293 R tRNA-Glu complement(1944221..1944293) Corynebacterium diphtheriae NCTC 13129 2648942 DIPt52 tRNA tRNA-Lys NC_002935.2 1950154 1950226 R tRNA-Lys complement(1950154..1950226) Corynebacterium diphtheriae NCTC 13129 2648947 DIPt53 tRNA tRNA-Thr NC_002935.2 2011963 2012035 R tRNA-Thr complement(2011963..2012035) Corynebacterium diphtheriae NCTC 13129 2649010 DIPt54 tRNA tRNA-Gly NC_002935.2 2209315 2209385 D tRNA-Gly 2209315..2209385 Corynebacterium diphtheriae NCTC 13129 2649613 DIP0766.1 rRNA 16S_rRNA NC_002935.2 743383 744774 D 16S ribosomal RNA 743383..744774 Corynebacterium diphtheriae NCTC 13129 2648650 DIPr02 rRNA 23S_rRNA NC_002935.2 745234 748318 D possible 23S ribosomal RNA 745234..748318 Corynebacterium diphtheriae NCTC 13129 2648651 DIPr03 rRNA 5S_rRNA NC_002935.2 748458 748578 D 5S ribosomal RNA 748458..748578 Corynebacterium diphtheriae NCTC 13129 2648652 DIPr04 rRNA 16S_rRNA NC_002935.2 1170343 1171734 D 16S ribosomal RNA 1170343..1171734 Corynebacterium diphtheriae NCTC 13129 2649729 DIPr05 rRNA 23S_rRNA NC_002935.2 1172194 1175278 D possible 23S ribosomal RNA 1172194..1175278 Corynebacterium diphtheriae NCTC 13129 2649730 DIPr06 rRNA 5S_rRNA NC_002935.2 1175418 1175538 D 5S ribosomal RNA 1175418..1175538 Corynebacterium diphtheriae NCTC 13129 2649731 DIPr07 rRNA 5S_rRNA NC_002935.2 1931339 1931459 R 5S ribosomal RNA complement(1931339..1931459) Corynebacterium diphtheriae NCTC 13129 2649263 DIPr08 rRNA 23S_rRNA NC_002935.2 1931599 1934685 R possible 23S ribosomal RNA complement(1931599..1934685) Corynebacterium diphtheriae NCTC 13129 2649264 DIPr09 rRNA 16S_rRNA NC_002935.2 1935145 1936536 R 16S ribosomal RNA complement(1935145..1936536) Corynebacterium diphtheriae NCTC 13129 2649265 DIPr10 rRNA 5S_rRNA NC_002935.2 2184694 2184814 R 5S ribosomal RNA complement(2184694..2184814) Corynebacterium diphtheriae NCTC 13129 2649597 DIPr11 rRNA 23S_rRNA NC_002935.2 2184953 2188037 R possible 23S ribosomal RNA complement(2184953..2188037) Corynebacterium diphtheriae NCTC 13129 2649598 DIPr12 rRNA 16S_rRNA NC_002935.2 2188497 2189888 R 16S ribosomal RNA complement(2188497..2189888) Corynebacterium diphtheriae NCTC 13129 2649599 DIPr13 rRNA 5S_rRNA NC_002935.2 2369527 2369647 R 5S ribosomal RNA complement(2369527..2369647) Corynebacterium diphtheriae NCTC 13129 2650074 DIPr14 rRNA 23S_rRNA NC_002935.2 2369786 2372870 R possible 23S ribosomal RNA complement(2369786..2372870) Corynebacterium diphtheriae NCTC 13129 2650075 DIPr15 rRNA 16S_rRNA NC_002935.2 2373330 2374721 R 16S ribosomal RNA complement(2373330..2374721) Corynebacterium diphtheriae NCTC 13129 2650076