-- dump date 20140619_051220 -- class Genbank::misc_feature -- table misc_feature_note -- id note 698964000001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698964000002 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 698964000003 Walker A motif; other site 698964000004 ATP binding site [chemical binding]; other site 698964000005 Walker B motif; other site 698964000006 arginine finger; other site 698964000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 698964000008 DnaA box-binding interface [nucleotide binding]; other site 698964000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 698964000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 698964000011 putative DNA binding surface [nucleotide binding]; other site 698964000012 dimer interface [polypeptide binding]; other site 698964000013 beta-clamp/clamp loader binding surface; other site 698964000014 beta-clamp/translesion DNA polymerase binding surface; other site 698964000015 recombination protein F; Reviewed; Region: recF; PRK00064 698964000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 698964000017 Walker A/P-loop; other site 698964000018 ATP binding site [chemical binding]; other site 698964000019 Q-loop/lid; other site 698964000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698964000021 ABC transporter signature motif; other site 698964000022 Walker B; other site 698964000023 D-loop; other site 698964000024 H-loop/switch region; other site 698964000025 hypothetical protein; Provisional; Region: PRK00111 698964000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 698964000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698964000028 ATP binding site [chemical binding]; other site 698964000029 Mg2+ binding site [ion binding]; other site 698964000030 G-X-G motif; other site 698964000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 698964000032 anchoring element; other site 698964000033 dimer interface [polypeptide binding]; other site 698964000034 ATP binding site [chemical binding]; other site 698964000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 698964000036 active site 698964000037 putative metal-binding site [ion binding]; other site 698964000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 698964000039 DNA gyrase subunit A; Validated; Region: PRK05560 698964000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 698964000041 CAP-like domain; other site 698964000042 active site 698964000043 primary dimer interface [polypeptide binding]; other site 698964000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698964000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698964000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698964000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698964000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698964000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698964000050 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 698964000051 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 698964000052 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 698964000053 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 698964000054 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698964000055 putative ligand binding site [chemical binding]; other site 698964000056 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698964000057 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698964000058 TM-ABC transporter signature motif; other site 698964000059 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698964000060 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698964000061 Walker A/P-loop; other site 698964000062 ATP binding site [chemical binding]; other site 698964000063 Q-loop/lid; other site 698964000064 ABC transporter signature motif; other site 698964000065 Walker B; other site 698964000066 D-loop; other site 698964000067 H-loop/switch region; other site 698964000068 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 698964000069 active site 698964000070 Integrase core domain; Region: rve_2; pfam13333 698964000071 Rhomboid family; Region: Rhomboid; pfam01694 698964000072 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 698964000073 ThiC-associated domain; Region: ThiC-associated; pfam13667 698964000074 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 698964000075 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 698964000076 active site 698964000077 thiamine phosphate binding site [chemical binding]; other site 698964000078 pyrophosphate binding site [ion binding]; other site 698964000079 hydroxyglutarate oxidase; Provisional; Region: PRK11728 698964000080 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 698964000081 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 698964000082 ThiS interaction site; other site 698964000083 putative active site [active] 698964000084 tetramer interface [polypeptide binding]; other site 698964000085 thiamine biosynthesis protein ThiF; Validated; Region: PRK05600 698964000086 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 698964000087 ATP binding site [chemical binding]; other site 698964000088 substrate interface [chemical binding]; other site 698964000089 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698964000090 active site residue [active] 698964000091 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 698964000092 dimer interface [polypeptide binding]; other site 698964000093 substrate binding site [chemical binding]; other site 698964000094 ATP binding site [chemical binding]; other site 698964000095 helicase Cas3; Provisional; Region: PRK09694 698964000096 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 698964000097 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698964000098 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044 698964000099 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 698964000100 CT1975-like protein; Region: Cas_CT1975; pfam09344 698964000101 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 698964000102 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 698964000103 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 698964000104 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 698964000105 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 698964000106 putative septation inhibitor protein; Reviewed; Region: PRK00159 698964000107 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 698964000108 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698964000109 active site 698964000110 ATP binding site [chemical binding]; other site 698964000111 substrate binding site [chemical binding]; other site 698964000112 activation loop (A-loop); other site 698964000113 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 698964000114 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698964000115 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698964000116 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698964000117 PASTA domain; Region: PASTA; pfam03793 698964000118 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698964000119 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698964000120 active site 698964000121 ATP binding site [chemical binding]; other site 698964000122 substrate binding site [chemical binding]; other site 698964000123 activation loop (A-loop); other site 698964000124 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 698964000125 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698964000126 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 698964000127 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 698964000128 Protein phosphatase 2C; Region: PP2C; pfam00481 698964000129 active site 698964000130 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 698964000131 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 698964000132 phosphopeptide binding site; other site 698964000133 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 698964000134 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 698964000135 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 698964000136 phosphopeptide binding site; other site 698964000137 DDE domain; Region: DDE_Tnp_IS240; pfam13610 698964000138 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 698964000139 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 698964000140 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698964000141 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698964000142 motif I; other site 698964000143 motif II; other site 698964000144 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698964000145 metal-binding site [ion binding] 698964000146 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 698964000147 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 698964000148 Multicopper oxidase; Region: Cu-oxidase; pfam00394 698964000149 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 698964000150 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698964000151 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698964000152 dimerization interface [polypeptide binding]; other site 698964000153 putative DNA binding site [nucleotide binding]; other site 698964000154 putative Zn2+ binding site [ion binding]; other site 698964000155 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 698964000156 Cadmium resistance transporter; Region: Cad; pfam03596 698964000157 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 698964000158 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 698964000159 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698964000160 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698964000161 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698964000162 mercuric reductase; Region: MerA; TIGR02053 698964000163 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698964000164 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698964000165 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 698964000166 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698964000167 catalytic residues [active] 698964000168 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 698964000169 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 698964000170 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 698964000171 DNA binding residues [nucleotide binding] 698964000172 dimer interface [polypeptide binding]; other site 698964000173 metal binding site [ion binding]; metal-binding site 698964000174 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 698964000175 NIPSNAP; Region: NIPSNAP; pfam07978 698964000176 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 698964000177 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 698964000178 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698964000179 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 698964000180 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698964000181 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 698964000182 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 698964000183 putative metal binding site [ion binding]; other site 698964000184 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698964000185 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698964000186 HTH-like domain; Region: HTH_21; pfam13276 698964000187 Integrase core domain; Region: rve; pfam00665 698964000188 Integrase core domain; Region: rve_2; pfam13333 698964000189 biotin synthase; Validated; Region: PRK06256 698964000190 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698964000191 FeS/SAM binding site; other site 698964000192 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 698964000193 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 698964000194 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 698964000195 putative ligand binding residues [chemical binding]; other site 698964000196 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698964000197 ABC-ATPase subunit interface; other site 698964000198 dimer interface [polypeptide binding]; other site 698964000199 putative PBP binding regions; other site 698964000200 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698964000201 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698964000202 Walker A/P-loop; other site 698964000203 ATP binding site [chemical binding]; other site 698964000204 Q-loop/lid; other site 698964000205 ABC transporter signature motif; other site 698964000206 Walker B; other site 698964000207 D-loop; other site 698964000208 H-loop/switch region; other site 698964000209 Uncharacterized conserved protein [Function unknown]; Region: COG5646 698964000210 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 698964000211 DNA photolyase; Region: DNA_photolyase; pfam00875 698964000212 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 698964000213 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 698964000214 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 698964000215 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 698964000216 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 698964000217 Lipase (class 2); Region: Lipase_2; pfam01674 698964000218 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370 698964000219 dimer interface [polypeptide binding]; other site 698964000220 FMN binding site [chemical binding]; other site 698964000221 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698964000222 Divergent AAA domain; Region: AAA_4; pfam04326 698964000223 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698964000224 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698964000225 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 698964000226 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 698964000227 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 698964000228 trimer interface [polypeptide binding]; other site 698964000229 putative metal binding site [ion binding]; other site 698964000230 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698964000231 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 698964000232 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 698964000233 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 698964000234 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698964000235 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 698964000236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805 698964000237 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698964000238 MarR family; Region: MarR; pfam01047 698964000239 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 698964000240 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 698964000241 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 698964000242 hypothetical protein; Provisional; Region: PRK10621 698964000243 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 698964000244 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 698964000245 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698964000246 ATP binding site [chemical binding]; other site 698964000247 putative Mg++ binding site [ion binding]; other site 698964000248 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698964000249 nucleotide binding region [chemical binding]; other site 698964000250 Helicase associated domain (HA2); Region: HA2; pfam04408 698964000251 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 698964000252 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 698964000253 maltose O-acetyltransferase; Provisional; Region: PRK10092 698964000254 active site 698964000255 substrate binding site [chemical binding]; other site 698964000256 trimer interface [polypeptide binding]; other site 698964000257 CoA binding site [chemical binding]; other site 698964000258 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 698964000259 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 698964000260 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 698964000261 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698964000262 NAD(P) binding site [chemical binding]; other site 698964000263 active site 698964000264 potential frameshift: common BLAST hit: gi|336325819|ref|YP_004605785.1| transposase for insertion sequence element 698964000265 potential frameshift: common BLAST hit: gi|336325819|ref|YP_004605785.1| transposase for insertion sequence element 698964000266 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698964000267 Integrase core domain; Region: rve; pfam00665 698964000268 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698964000269 Integrase core domain; Region: rve; pfam00665 698964000270 SdpI/YhfL protein family; Region: SdpI; pfam13630 698964000271 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698964000272 RNA binding surface [nucleotide binding]; other site 698964000273 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 698964000274 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698964000275 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 698964000276 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 698964000277 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 698964000278 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 698964000279 active site 698964000280 Zn binding site [ion binding]; other site 698964000281 Protease prsW family; Region: PrsW-protease; pfam13367 698964000282 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 698964000283 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 698964000284 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 698964000285 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 698964000286 short chain dehydrogenase; Provisional; Region: PRK07904 698964000287 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698964000288 NAD(P) binding site [chemical binding]; other site 698964000289 active site 698964000290 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 698964000291 FAD binding domain; Region: FAD_binding_4; pfam01565 698964000292 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 698964000293 Predicted membrane protein [Function unknown]; Region: COG2246 698964000294 GtrA-like protein; Region: GtrA; pfam04138 698964000295 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698964000296 putative active site [active] 698964000297 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 698964000298 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698964000299 active site 698964000300 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698964000301 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698964000302 intersubunit interface [polypeptide binding]; other site 698964000303 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698964000304 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698964000305 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698964000306 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698964000307 putative PBP binding regions; other site 698964000308 ABC-ATPase subunit interface; other site 698964000309 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698964000310 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698964000311 ABC-ATPase subunit interface; other site 698964000312 dimer interface [polypeptide binding]; other site 698964000313 putative PBP binding regions; other site 698964000314 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698964000315 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698964000316 intersubunit interface [polypeptide binding]; other site 698964000317 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 698964000318 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 698964000319 Walker A/P-loop; other site 698964000320 ATP binding site [chemical binding]; other site 698964000321 Q-loop/lid; other site 698964000322 ABC transporter signature motif; other site 698964000323 Walker B; other site 698964000324 D-loop; other site 698964000325 H-loop/switch region; other site 698964000326 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 698964000327 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 698964000328 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 698964000329 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698964000330 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698964000331 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 698964000332 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 698964000333 NAD(P) binding site [chemical binding]; other site 698964000334 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 698964000335 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698964000336 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698964000337 homodimer interface [polypeptide binding]; other site 698964000338 catalytic residue [active] 698964000339 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 698964000340 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 698964000341 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 698964000342 active site 698964000343 catalytic residues [active] 698964000344 DNA binding site [nucleotide binding] 698964000345 Int/Topo IB signature motif; other site 698964000346 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698964000347 sequence-specific DNA binding site [nucleotide binding]; other site 698964000348 salt bridge; other site 698964000349 Domain of unknown function (DUF955); Region: DUF955; cl01076 698964000350 Domain of unknown function (DUF955); Region: DUF955; pfam06114 698964000351 Prophage antirepressor [Transcription]; Region: COG3617 698964000352 BRO family, N-terminal domain; Region: Bro-N; smart01040 698964000353 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 698964000354 Helix-turn-helix domain; Region: HTH_17; pfam12728 698964000355 Phage Terminase; Region: Terminase_1; pfam03354 698964000356 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698964000357 Phage-related protein [Function unknown]; Region: COG4695; cl01923 698964000358 Phage portal protein; Region: Phage_portal; pfam04860 698964000359 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 698964000360 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 698964000361 Phage capsid family; Region: Phage_capsid; pfam05065 698964000362 Phage-related minor tail protein [Function unknown]; Region: COG5280 698964000363 Phage tail repeat like; Region: PTR; pfam12789 698964000364 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 698964000365 amidase catalytic site [active] 698964000366 Zn binding residues [ion binding]; other site 698964000367 substrate binding site [chemical binding]; other site 698964000368 ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell; Region: ADP_ribosyl; cd01341 698964000369 nad+ binding pocket [chemical binding]; other site 698964000370 Diphtheria toxin, T domain; Region: Diphtheria_T; pfam02764 698964000371 Diphtheria toxin, R domain; Region: Diphtheria_R; pfam01324 698964000372 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 698964000373 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 698964000374 transmembrane helices; other site 698964000375 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 698964000376 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 698964000377 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 698964000378 active site 698964000379 catalytic residues [active] 698964000380 DNA binding site [nucleotide binding] 698964000381 Int/Topo IB signature motif; other site 698964000382 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698964000383 sequence-specific DNA binding site [nucleotide binding]; other site 698964000384 salt bridge; other site 698964000385 Domain of unknown function (DUF955); Region: DUF955; cl01076 698964000386 Domain of unknown function (DUF955); Region: DUF955; pfam06114 698964000387 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698964000388 non-specific DNA binding site [nucleotide binding]; other site 698964000389 salt bridge; other site 698964000390 sequence-specific DNA binding site [nucleotide binding]; other site 698964000391 Prophage antirepressor [Transcription]; Region: COG3617 698964000392 BRO family, N-terminal domain; Region: Bro-N; smart01040 698964000393 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 698964000394 Helix-turn-helix domain; Region: HTH_17; pfam12728 698964000395 Phage Terminase; Region: Terminase_1; pfam03354 698964000396 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698964000397 Phage-related protein [Function unknown]; Region: COG4695; cl01923 698964000398 Phage portal protein; Region: Phage_portal; pfam04860 698964000399 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 698964000400 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 698964000401 Phage capsid family; Region: Phage_capsid; pfam05065 698964000402 Phage-related minor tail protein [Function unknown]; Region: COG5280 698964000403 Phage tail repeat like; Region: PTR; pfam12789 698964000404 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 698964000405 amidase catalytic site [active] 698964000406 Zn binding residues [ion binding]; other site 698964000407 substrate binding site [chemical binding]; other site 698964000408 ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell; Region: ADP_ribosyl; cd01341 698964000409 nad+ binding pocket [chemical binding]; other site 698964000410 Diphtheria toxin, T domain; Region: Diphtheria_T; pfam02764 698964000411 Diphtheria toxin, R domain; Region: Diphtheria_R; pfam01324 698964000412 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 698964000413 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 698964000414 NodB motif; other site 698964000415 active site 698964000416 catalytic site [active] 698964000417 metal binding site [ion binding]; metal-binding site 698964000418 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 698964000419 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698964000420 DNA-binding site [nucleotide binding]; DNA binding site 698964000421 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698964000422 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698964000423 homodimer interface [polypeptide binding]; other site 698964000424 catalytic residue [active] 698964000425 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 698964000426 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 698964000427 active site 698964000428 multimer interface [polypeptide binding]; other site 698964000429 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 698964000430 predicted active site [active] 698964000431 catalytic triad [active] 698964000432 potential frameshift: common BLAST hit: gi|62389924|ref|YP_225326.1| transposase 698964000433 potential frameshift: common BLAST hit: gi|62389924|ref|YP_225326.1| transposase 698964000434 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698964000435 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698964000436 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698964000437 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 698964000438 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698964000439 active site 698964000440 catalytic site [active] 698964000441 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698964000442 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698964000443 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698964000444 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698964000445 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698964000446 non-specific DNA binding site [nucleotide binding]; other site 698964000447 salt bridge; other site 698964000448 sequence-specific DNA binding site [nucleotide binding]; other site 698964000449 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698964000450 ABC transporter signature motif; other site 698964000451 Walker B; other site 698964000452 D-loop; other site 698964000453 H-loop/switch region; other site 698964000454 potential frameshift: common BLAST hit: gi|62389924|ref|YP_225326.1| transposase 698964000455 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698964000456 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698964000457 Fic family protein [Function unknown]; Region: COG3177 698964000458 Fic/DOC family; Region: Fic; pfam02661 698964000459 T5orf172 domain; Region: T5orf172; pfam10544 698964000460 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 698964000461 MULE transposase domain; Region: MULE; pfam10551 698964000462 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 698964000463 prephenate dehydrogenase; Validated; Region: PRK08507 698964000464 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 698964000465 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 698964000466 nucleoside/Zn binding site; other site 698964000467 dimer interface [polypeptide binding]; other site 698964000468 catalytic motif [active] 698964000469 DNA binding domain, excisionase family; Region: excise; TIGR01764 698964000470 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 698964000471 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 698964000472 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 698964000473 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 698964000474 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 698964000475 active site 698964000476 HIGH motif; other site 698964000477 nucleotide binding site [chemical binding]; other site 698964000478 active site 698964000479 KMSKS motif; other site 698964000480 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 698964000481 fructuronate transporter; Provisional; Region: PRK10034; cl15264 698964000482 Shikimate kinase; Region: SKI; pfam01202 698964000483 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 698964000484 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 698964000485 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 698964000486 putative NAD(P) binding site [chemical binding]; other site 698964000487 catalytic Zn binding site [ion binding]; other site 698964000488 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 698964000489 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 698964000490 NADP binding site [chemical binding]; other site 698964000491 homodimer interface [polypeptide binding]; other site 698964000492 active site 698964000493 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 698964000494 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698964000495 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698964000496 homodimer interface [polypeptide binding]; other site 698964000497 catalytic residue [active] 698964000498 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 698964000499 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 698964000500 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698964000501 Walker A motif; other site 698964000502 ATP binding site [chemical binding]; other site 698964000503 Walker B motif; other site 698964000504 arginine finger; other site 698964000505 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 698964000506 hypothetical protein; Validated; Region: PRK00153 698964000507 recombination protein RecR; Reviewed; Region: recR; PRK00076 698964000508 RecR protein; Region: RecR; pfam02132 698964000509 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 698964000510 putative active site [active] 698964000511 putative metal-binding site [ion binding]; other site 698964000512 tetramer interface [polypeptide binding]; other site 698964000513 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 698964000514 catalytic triad [active] 698964000515 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 698964000516 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698964000517 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 698964000518 DNA polymerase III subunit epsilon; Validated; Region: PRK05601 698964000519 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698964000520 active site 698964000521 catalytic site [active] 698964000522 substrate binding site [chemical binding]; other site 698964000523 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 698964000524 dimer interface [polypeptide binding]; other site 698964000525 FMN binding site [chemical binding]; other site 698964000526 NADPH bind site [chemical binding]; other site 698964000527 2-isopropylmalate synthase; Validated; Region: PRK03739 698964000528 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 698964000529 active site 698964000530 catalytic residues [active] 698964000531 metal binding site [ion binding]; metal-binding site 698964000532 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 698964000533 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 698964000534 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698964000535 DNA binding residues [nucleotide binding] 698964000536 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 698964000537 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698964000538 active site 698964000539 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 698964000540 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698964000541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698964000542 putative substrate translocation pore; other site 698964000543 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 698964000544 intersubunit interface [polypeptide binding]; other site 698964000545 active site 698964000546 catalytic residue [active] 698964000547 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 698964000548 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 698964000549 active site 698964000550 substrate binding site [chemical binding]; other site 698964000551 metal binding site [ion binding]; metal-binding site 698964000552 aspartate kinase; Reviewed; Region: PRK06635 698964000553 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 698964000554 putative nucleotide binding site [chemical binding]; other site 698964000555 putative catalytic residues [active] 698964000556 putative Mg ion binding site [ion binding]; other site 698964000557 putative aspartate binding site [chemical binding]; other site 698964000558 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 698964000559 putative allosteric regulatory site; other site 698964000560 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 698964000561 putative allosteric regulatory residue; other site 698964000562 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 698964000563 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 698964000564 RNA polymerase sigma factor; Provisional; Region: PRK12535 698964000565 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698964000566 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 698964000567 DNA binding residues [nucleotide binding] 698964000568 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 698964000569 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 698964000570 heme binding pocket [chemical binding]; other site 698964000571 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 698964000572 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698964000573 Walker A/P-loop; other site 698964000574 ATP binding site [chemical binding]; other site 698964000575 Q-loop/lid; other site 698964000576 ABC transporter signature motif; other site 698964000577 Walker B; other site 698964000578 D-loop; other site 698964000579 H-loop/switch region; other site 698964000580 TOBE domain; Region: TOBE_2; pfam08402 698964000581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698964000582 dimer interface [polypeptide binding]; other site 698964000583 conserved gate region; other site 698964000584 ABC-ATPase subunit interface; other site 698964000585 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 698964000586 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 698964000587 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698964000588 putative substrate translocation pore; other site 698964000589 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698964000590 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698964000591 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698964000592 active site 698964000593 phosphorylation site [posttranslational modification] 698964000594 intermolecular recognition site; other site 698964000595 dimerization interface [polypeptide binding]; other site 698964000596 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698964000597 DNA binding site [nucleotide binding] 698964000598 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698964000599 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698964000600 dimer interface [polypeptide binding]; other site 698964000601 phosphorylation site [posttranslational modification] 698964000602 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698964000603 ATP binding site [chemical binding]; other site 698964000604 Mg2+ binding site [ion binding]; other site 698964000605 G-X-G motif; other site 698964000606 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 698964000607 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612 698964000608 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654 698964000609 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 698964000610 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698964000611 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 698964000612 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 698964000613 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698964000614 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 698964000615 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 698964000616 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 698964000617 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698964000618 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 698964000619 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698964000620 putative active site [active] 698964000621 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 698964000622 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698964000623 putative active site [active] 698964000624 putative metal binding site [ion binding]; other site 698964000625 Yqey-like protein; Region: YqeY; pfam09424 698964000626 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 698964000627 Transglycosylase; Region: Transgly; pfam00912 698964000628 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 698964000629 PASTA domain; Region: PASTA; pfam03793 698964000630 Transcription factor WhiB; Region: Whib; pfam02467 698964000631 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 698964000632 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 698964000633 homotrimer interaction site [polypeptide binding]; other site 698964000634 putative active site [active] 698964000635 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698964000636 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 698964000637 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698964000638 ligand binding site [chemical binding]; other site 698964000639 flexible hinge region; other site 698964000640 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 698964000641 putative switch regulator; other site 698964000642 non-specific DNA interactions [nucleotide binding]; other site 698964000643 DNA binding site [nucleotide binding] 698964000644 sequence specific DNA binding site [nucleotide binding]; other site 698964000645 putative cAMP binding site [chemical binding]; other site 698964000646 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 698964000647 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698964000648 minor groove reading motif; other site 698964000649 helix-hairpin-helix signature motif; other site 698964000650 substrate binding pocket [chemical binding]; other site 698964000651 active site 698964000652 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 698964000653 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 698964000654 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698964000655 catalytic residues [active] 698964000656 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 698964000657 putative active site [active] 698964000658 putative CoA binding site [chemical binding]; other site 698964000659 nudix motif; other site 698964000660 metal binding site [ion binding]; metal-binding site 698964000661 Colicin V production protein; Region: Colicin_V; pfam02674 698964000662 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 698964000663 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 698964000664 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698964000665 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698964000666 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 698964000667 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 698964000668 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698964000669 motif II; other site 698964000670 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 698964000671 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 698964000672 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 698964000673 ATP binding site [chemical binding]; other site 698964000674 Walker A motif; other site 698964000675 hexamer interface [polypeptide binding]; other site 698964000676 Walker B motif; other site 698964000677 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 698964000678 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 698964000679 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 698964000680 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698964000681 ATP binding site [chemical binding]; other site 698964000682 putative Mg++ binding site [ion binding]; other site 698964000683 nucleotide binding region [chemical binding]; other site 698964000684 helicase superfamily c-terminal domain; Region: HELICc; smart00490 698964000685 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 698964000686 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698964000687 DNA-binding site [nucleotide binding]; DNA binding site 698964000688 RNA-binding motif; other site 698964000689 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698964000690 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698964000691 Walker A/P-loop; other site 698964000692 ATP binding site [chemical binding]; other site 698964000693 Q-loop/lid; other site 698964000694 ABC transporter signature motif; other site 698964000695 Walker B; other site 698964000696 D-loop; other site 698964000697 H-loop/switch region; other site 698964000698 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698964000699 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 698964000700 Walker A/P-loop; other site 698964000701 ATP binding site [chemical binding]; other site 698964000702 Q-loop/lid; other site 698964000703 ABC transporter signature motif; other site 698964000704 Walker B; other site 698964000705 D-loop; other site 698964000706 H-loop/switch region; other site 698964000707 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698964000708 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698964000709 putative substrate translocation pore; other site 698964000710 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698964000711 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 698964000712 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698964000713 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 698964000714 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698964000715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698964000716 dimer interface [polypeptide binding]; other site 698964000717 conserved gate region; other site 698964000718 putative PBP binding loops; other site 698964000719 ABC-ATPase subunit interface; other site 698964000720 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 698964000721 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698964000722 NAD(P) binding site [chemical binding]; other site 698964000723 active site 698964000724 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 698964000725 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 698964000726 DNA topoisomerase I, bacterial; Region: topA_bact; TIGR01051 698964000727 active site 698964000728 interdomain interaction site; other site 698964000729 putative metal-binding site [ion binding]; other site 698964000730 nucleotide binding site [chemical binding]; other site 698964000731 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 698964000732 domain I; other site 698964000733 DNA binding groove [nucleotide binding] 698964000734 phosphate binding site [ion binding]; other site 698964000735 domain II; other site 698964000736 domain III; other site 698964000737 nucleotide binding site [chemical binding]; other site 698964000738 catalytic site [active] 698964000739 domain IV; other site 698964000740 Uncharacterized C-terminal domain of topoisomerase IA [General function prediction only]; Region: COG1754 698964000741 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 698964000742 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 698964000743 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 698964000744 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 698964000745 active site 698964000746 Predicted membrane protein [Function unknown]; Region: COG1297 698964000747 putative oligopeptide transporter, OPT family; Region: TIGR00733 698964000748 Laminin G domain; Region: Laminin_G_2; pfam02210 698964000749 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 698964000750 catalytic site [active] 698964000751 Asp-box motif; other site 698964000752 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698964000753 dimerization interface [polypeptide binding]; other site 698964000754 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698964000755 cyclase homology domain; Region: CHD; cd07302 698964000756 nucleotidyl binding site; other site 698964000757 metal binding site [ion binding]; metal-binding site 698964000758 dimer interface [polypeptide binding]; other site 698964000759 DNA polymerase III subunit delta'; Validated; Region: PRK07940 698964000760 DNA polymerase III subunit delta'; Validated; Region: PRK08485 698964000761 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 698964000762 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 698964000763 active site 698964000764 catalytic residues [active] 698964000765 DNA binding site [nucleotide binding] 698964000766 Int/Topo IB signature motif; other site 698964000767 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 698964000768 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 698964000769 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 698964000770 Fic family protein [Function unknown]; Region: COG3177 698964000771 Fic/DOC family; Region: Fic; pfam02661 698964000772 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 698964000773 Trypsin; Region: Trypsin; pfam00089 698964000774 active site 698964000775 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 698964000776 putative DNA binding site [nucleotide binding]; other site 698964000777 putative Zn2+ binding site [ion binding]; other site 698964000778 Integrase core domain; Region: rve; pfam00665 698964000779 acyl-CoA synthetase; Validated; Region: PRK07788 698964000780 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698964000781 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698964000782 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698964000783 acyl-activating enzyme (AAE) consensus motif; other site 698964000784 acyl-activating enzyme (AAE) consensus motif; other site 698964000785 AMP binding site [chemical binding]; other site 698964000786 active site 698964000787 CoA binding site [chemical binding]; other site 698964000788 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 698964000789 active site 698964000790 catalytic triad [active] 698964000791 oxyanion hole [active] 698964000792 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 698964000793 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 698964000794 substrate binding site; other site 698964000795 tetramer interface; other site 698964000796 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 698964000797 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 698964000798 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 698964000799 NADP binding site [chemical binding]; other site 698964000800 active site 698964000801 putative substrate binding site [chemical binding]; other site 698964000802 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 698964000803 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 698964000804 NAD binding site [chemical binding]; other site 698964000805 substrate binding site [chemical binding]; other site 698964000806 homodimer interface [polypeptide binding]; other site 698964000807 active site 698964000808 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 698964000809 Zn binding site [ion binding]; other site 698964000810 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 698964000811 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698964000812 Putative esterase; Region: Esterase; pfam00756 698964000813 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 698964000814 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 698964000815 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698964000816 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698964000817 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698964000818 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698964000819 non-specific DNA binding site [nucleotide binding]; other site 698964000820 salt bridge; other site 698964000821 sequence-specific DNA binding site [nucleotide binding]; other site 698964000822 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 698964000823 Domain of unknown function (DUF955); Region: DUF955; pfam06114 698964000824 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 698964000825 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 698964000826 putative Iron-sulfur protein interface [polypeptide binding]; other site 698964000827 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 698964000828 proximal heme binding site [chemical binding]; other site 698964000829 distal heme binding site [chemical binding]; other site 698964000830 putative dimer interface [polypeptide binding]; other site 698964000831 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 698964000832 L-aspartate oxidase; Provisional; Region: PRK06175 698964000833 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 698964000834 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 698964000835 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 698964000836 Predicted membrane protein [Function unknown]; Region: COG2733 698964000837 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 698964000838 Class I aldolases; Region: Aldolase_Class_I; cd00945 698964000839 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 698964000840 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 698964000841 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698964000842 FeS/SAM binding site; other site 698964000843 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 698964000844 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 698964000845 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 698964000846 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698964000847 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 698964000848 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 698964000849 FAD binding domain; Region: FAD_binding_4; pfam01565 698964000850 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 698964000851 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 698964000852 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698964000853 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698964000854 acyl-activating enzyme (AAE) consensus motif; other site 698964000855 AMP binding site [chemical binding]; other site 698964000856 active site 698964000857 CoA binding site [chemical binding]; other site 698964000858 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 698964000859 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698964000860 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698964000861 acyl-activating enzyme (AAE) consensus motif; other site 698964000862 AMP binding site [chemical binding]; other site 698964000863 active site 698964000864 CoA binding site [chemical binding]; other site 698964000865 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 698964000866 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 698964000867 putative ADP-binding pocket [chemical binding]; other site 698964000868 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698964000869 catalytic core [active] 698964000870 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698964000871 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 698964000872 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698964000873 dimer interface [polypeptide binding]; other site 698964000874 phosphorylation site [posttranslational modification] 698964000875 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698964000876 ATP binding site [chemical binding]; other site 698964000877 Mg2+ binding site [ion binding]; other site 698964000878 G-X-G motif; other site 698964000879 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698964000880 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698964000881 active site 698964000882 phosphorylation site [posttranslational modification] 698964000883 intermolecular recognition site; other site 698964000884 dimerization interface [polypeptide binding]; other site 698964000885 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698964000886 DNA binding site [nucleotide binding] 698964000887 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 698964000888 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 698964000889 DNA binding domain, excisionase family; Region: excise; TIGR01764 698964000890 Thioredoxin; Region: Thioredoxin_4; cl17273 698964000891 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 698964000892 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 698964000893 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 698964000894 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698964000895 motif II; other site 698964000896 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 698964000897 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 698964000898 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 698964000899 tRNA; other site 698964000900 putative tRNA binding site [nucleotide binding]; other site 698964000901 putative NADP binding site [chemical binding]; other site 698964000902 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 698964000903 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 698964000904 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 698964000905 domain interfaces; other site 698964000906 active site 698964000907 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 698964000908 active site 698964000909 homodimer interface [polypeptide binding]; other site 698964000910 SAM binding site [chemical binding]; other site 698964000911 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 698964000912 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 698964000913 active site 698964000914 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 698964000915 dimer interface [polypeptide binding]; other site 698964000916 active site 698964000917 Schiff base residues; other site 698964000918 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 698964000919 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698964000920 Predicted membrane protein [Function unknown]; Region: COG2311 698964000921 Protein of unknown function (DUF418); Region: DUF418; pfam04235 698964000922 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 698964000923 substrate binding site [chemical binding]; other site 698964000924 active site 698964000925 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 698964000926 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 698964000927 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698964000928 inhibitor-cofactor binding pocket; inhibition site 698964000929 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698964000930 catalytic residue [active] 698964000931 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698964000932 catalytic core [active] 698964000933 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 698964000934 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698964000935 catalytic residues [active] 698964000936 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 698964000937 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 698964000938 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 698964000939 ResB-like family; Region: ResB; pfam05140 698964000940 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 698964000941 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698964000942 dimerization interface [polypeptide binding]; other site 698964000943 putative DNA binding site [nucleotide binding]; other site 698964000944 putative Zn2+ binding site [ion binding]; other site 698964000945 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 698964000946 UbiA prenyltransferase family; Region: UbiA; pfam01040 698964000947 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698964000948 active site 698964000949 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698964000950 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 698964000951 acyl-activating enzyme (AAE) consensus motif; other site 698964000952 AMP binding site [chemical binding]; other site 698964000953 active site 698964000954 CoA binding site [chemical binding]; other site 698964000955 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698964000956 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 698964000957 substrate binding site [chemical binding]; other site 698964000958 oxyanion hole (OAH) forming residues; other site 698964000959 trimer interface [polypeptide binding]; other site 698964000960 O-succinylbenzoate synthase; Provisional; Region: PRK02901 698964000961 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 698964000962 active site 698964000963 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 698964000964 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 698964000965 dimer interface [polypeptide binding]; other site 698964000966 tetramer interface [polypeptide binding]; other site 698964000967 PYR/PP interface [polypeptide binding]; other site 698964000968 TPP binding site [chemical binding]; other site 698964000969 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 698964000970 TPP-binding site; other site 698964000971 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698964000972 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 698964000973 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 698964000974 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698964000975 S-adenosylmethionine binding site [chemical binding]; other site 698964000976 A subgroup of L-lactate dehydrogenases; Region: LDH_3; cd05290 698964000977 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 698964000978 NAD binding site [chemical binding]; other site 698964000979 dimer interface [polypeptide binding]; other site 698964000980 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698964000981 substrate binding site [chemical binding]; other site 698964000982 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 698964000983 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 698964000984 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 698964000985 substrate binding pocket [chemical binding]; other site 698964000986 chain length determination region; other site 698964000987 substrate-Mg2+ binding site; other site 698964000988 catalytic residues [active] 698964000989 aspartate-rich region 1; other site 698964000990 active site lid residues [active] 698964000991 aspartate-rich region 2; other site 698964000992 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 698964000993 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 698964000994 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 698964000995 putative homodimer interface [polypeptide binding]; other site 698964000996 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 698964000997 heterodimer interface [polypeptide binding]; other site 698964000998 homodimer interface [polypeptide binding]; other site 698964000999 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 698964001000 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 698964001001 23S rRNA interface [nucleotide binding]; other site 698964001002 L7/L12 interface [polypeptide binding]; other site 698964001003 putative thiostrepton binding site; other site 698964001004 L25 interface [polypeptide binding]; other site 698964001005 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 698964001006 mRNA/rRNA interface [nucleotide binding]; other site 698964001007 putative transposase OrfB; Reviewed; Region: PHA02517 698964001008 HTH-like domain; Region: HTH_21; pfam13276 698964001009 Integrase core domain; Region: rve; pfam00665 698964001010 Integrase core domain; Region: rve_2; pfam13333 698964001011 Homeodomain-like domain; Region: HTH_23; cl17451 698964001012 Helix-turn-helix domain; Region: HTH_28; pfam13518 698964001013 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 698964001014 23S rRNA interface [nucleotide binding]; other site 698964001015 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 698964001016 50S ribosomal protein L7/L12; Reviewed; Region: rplL; PRK00157 698964001017 L11 interface [polypeptide binding]; other site 698964001018 putative EF-Tu interaction site [polypeptide binding]; other site 698964001019 putative EF-G interaction site [polypeptide binding]; other site 698964001020 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 698964001021 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698964001022 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698964001023 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698964001024 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698964001025 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698964001026 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 698964001027 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698964001028 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698964001029 ABC-ATPase subunit interface; other site 698964001030 dimer interface [polypeptide binding]; other site 698964001031 putative PBP binding regions; other site 698964001032 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 698964001033 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698964001034 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698964001035 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 698964001036 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 698964001037 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 698964001038 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 698964001039 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 698964001040 RPB1 interaction site [polypeptide binding]; other site 698964001041 RPB10 interaction site [polypeptide binding]; other site 698964001042 RPB11 interaction site [polypeptide binding]; other site 698964001043 RPB3 interaction site [polypeptide binding]; other site 698964001044 RPB12 interaction site [polypeptide binding]; other site 698964001045 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 698964001046 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 698964001047 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 698964001048 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 698964001049 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 698964001050 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 698964001051 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 698964001052 G-loop; other site 698964001053 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 698964001054 DNA binding site [nucleotide binding] 698964001055 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 698964001056 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698964001057 Histidine kinase; Region: HisKA_3; pfam07730 698964001058 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698964001059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698964001060 active site 698964001061 phosphorylation site [posttranslational modification] 698964001062 intermolecular recognition site; other site 698964001063 dimerization interface [polypeptide binding]; other site 698964001064 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698964001065 DNA binding residues [nucleotide binding] 698964001066 dimerization interface [polypeptide binding]; other site 698964001067 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698964001068 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 698964001069 Walker A/P-loop; other site 698964001070 ATP binding site [chemical binding]; other site 698964001071 Q-loop/lid; other site 698964001072 ABC transporter signature motif; other site 698964001073 Walker B; other site 698964001074 D-loop; other site 698964001075 H-loop/switch region; other site 698964001076 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 698964001077 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 698964001078 TIGR03943 family protein; Region: TIGR03943 698964001079 Predicted permeases [General function prediction only]; Region: COG0701 698964001080 Radical SAM superfamily; Region: Radical_SAM; pfam04055 698964001081 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698964001082 FeS/SAM binding site; other site 698964001083 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 698964001084 Class III ribonucleotide reductase; Region: RNR_III; cd01675 698964001085 effector binding site; other site 698964001086 active site 698964001087 Zn binding site [ion binding]; other site 698964001088 glycine loop; other site 698964001089 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 698964001090 S17 interaction site [polypeptide binding]; other site 698964001091 S8 interaction site; other site 698964001092 16S rRNA interaction site [nucleotide binding]; other site 698964001093 streptomycin interaction site [chemical binding]; other site 698964001094 23S rRNA interaction site [nucleotide binding]; other site 698964001095 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 698964001096 30S ribosomal protein S7; Validated; Region: PRK05302 698964001097 elongation factor G; Reviewed; Region: PRK00007 698964001098 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 698964001099 G1 box; other site 698964001100 putative GEF interaction site [polypeptide binding]; other site 698964001101 GTP/Mg2+ binding site [chemical binding]; other site 698964001102 Switch I region; other site 698964001103 G2 box; other site 698964001104 G3 box; other site 698964001105 Switch II region; other site 698964001106 G4 box; other site 698964001107 G5 box; other site 698964001108 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 698964001109 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 698964001110 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 698964001111 elongation factor Tu; Reviewed; Region: PRK00049 698964001112 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 698964001113 G1 box; other site 698964001114 GEF interaction site [polypeptide binding]; other site 698964001115 GTP/Mg2+ binding site [chemical binding]; other site 698964001116 Switch I region; other site 698964001117 G2 box; other site 698964001118 G3 box; other site 698964001119 Switch II region; other site 698964001120 G4 box; other site 698964001121 G5 box; other site 698964001122 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 698964001123 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 698964001124 Antibiotic Binding Site [chemical binding]; other site 698964001125 Predicted membrane protein [Function unknown]; Region: COG2323 698964001126 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 698964001127 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 698964001128 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 698964001129 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 698964001130 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 698964001131 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 698964001132 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 698964001133 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 698964001134 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 698964001135 putative translocon binding site; other site 698964001136 protein-rRNA interface [nucleotide binding]; other site 698964001137 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 698964001138 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 698964001139 G-X-X-G motif; other site 698964001140 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 698964001141 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 698964001142 23S rRNA interface [nucleotide binding]; other site 698964001143 5S rRNA interface [nucleotide binding]; other site 698964001144 putative antibiotic binding site [chemical binding]; other site 698964001145 L25 interface [polypeptide binding]; other site 698964001146 L27 interface [polypeptide binding]; other site 698964001147 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 698964001148 putative translocon interaction site; other site 698964001149 23S rRNA interface [nucleotide binding]; other site 698964001150 signal recognition particle (SRP54) interaction site; other site 698964001151 L23 interface [polypeptide binding]; other site 698964001152 trigger factor interaction site; other site 698964001153 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 698964001154 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698964001155 HlyD family secretion protein; Region: HlyD_3; pfam13437 698964001156 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698964001157 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698964001158 Walker A/P-loop; other site 698964001159 ATP binding site [chemical binding]; other site 698964001160 Q-loop/lid; other site 698964001161 ABC transporter signature motif; other site 698964001162 Walker B; other site 698964001163 D-loop; other site 698964001164 H-loop/switch region; other site 698964001165 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698964001166 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698964001167 FtsX-like permease family; Region: FtsX; pfam02687 698964001168 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 698964001169 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 698964001170 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 698964001171 RNA binding site [nucleotide binding]; other site 698964001172 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 698964001173 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 698964001174 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 698964001175 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 698964001176 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 698964001177 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 698964001178 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 698964001179 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 698964001180 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 698964001181 active site 698964001182 homotetramer interface [polypeptide binding]; other site 698964001183 homodimer interface [polypeptide binding]; other site 698964001184 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK05597 698964001185 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 698964001186 ATP binding site [chemical binding]; other site 698964001187 substrate interface [chemical binding]; other site 698964001188 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698964001189 active site residue [active] 698964001190 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698964001191 MPT binding site; other site 698964001192 trimer interface [polypeptide binding]; other site 698964001193 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 698964001194 MoaE homodimer interface [polypeptide binding]; other site 698964001195 MoaD interaction [polypeptide binding]; other site 698964001196 active site residues [active] 698964001197 Ubiquitin-like proteins; Region: UBQ; cl00155 698964001198 charged pocket; other site 698964001199 hydrophobic patch; other site 698964001200 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 698964001201 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698964001202 putative PBP binding loops; other site 698964001203 ABC-ATPase subunit interface; other site 698964001204 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698964001205 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 698964001206 Walker A/P-loop; other site 698964001207 ATP binding site [chemical binding]; other site 698964001208 Q-loop/lid; other site 698964001209 ABC transporter signature motif; other site 698964001210 Walker B; other site 698964001211 D-loop; other site 698964001212 H-loop/switch region; other site 698964001213 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 698964001214 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 698964001215 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 698964001216 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 698964001217 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 698964001218 [4Fe-4S] binding site [ion binding]; other site 698964001219 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698964001220 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698964001221 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698964001222 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 698964001223 molybdopterin cofactor binding site; other site 698964001224 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 698964001225 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 698964001226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698964001227 putative substrate translocation pore; other site 698964001228 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698964001229 MPT binding site; other site 698964001230 trimer interface [polypeptide binding]; other site 698964001231 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 698964001232 GTP binding site; other site 698964001233 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 698964001234 trimer interface [polypeptide binding]; other site 698964001235 dimer interface [polypeptide binding]; other site 698964001236 putative active site [active] 698964001237 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 698964001238 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 698964001239 dimer interface [polypeptide binding]; other site 698964001240 putative functional site; other site 698964001241 putative MPT binding site; other site 698964001242 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 698964001243 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698964001244 FeS/SAM binding site; other site 698964001245 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 698964001246 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 698964001247 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698964001248 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 698964001249 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 698964001250 Integrase core domain; Region: rve_3; cl15866 698964001251 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 698964001252 hypothetical protein; Reviewed; Region: PRK09588 698964001253 Fic/DOC family; Region: Fic; pfam02661 698964001254 potential frameshift: common BLAST hit: gi|261416833|ref|YP_003250516.1| type II restriction enzyme (methylase subunit) 698964001255 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698964001256 potential frameshift: common BLAST hit: gi|224369162|ref|YP_002603326.1| putative type II restriction enzyme (methylase subunit) 698964001257 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698964001258 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698964001259 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 698964001260 inhibitor site; inhibition site 698964001261 active site 698964001262 dimer interface [polypeptide binding]; other site 698964001263 catalytic residue [active] 698964001264 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 698964001265 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698964001266 Walker A/P-loop; other site 698964001267 ATP binding site [chemical binding]; other site 698964001268 Q-loop/lid; other site 698964001269 ABC transporter signature motif; other site 698964001270 Walker B; other site 698964001271 D-loop; other site 698964001272 H-loop/switch region; other site 698964001273 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698964001274 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698964001275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698964001276 dimer interface [polypeptide binding]; other site 698964001277 conserved gate region; other site 698964001278 putative PBP binding loops; other site 698964001279 ABC-ATPase subunit interface; other site 698964001280 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 698964001281 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698964001282 Walker A/P-loop; other site 698964001283 ATP binding site [chemical binding]; other site 698964001284 Q-loop/lid; other site 698964001285 ABC transporter signature motif; other site 698964001286 Walker B; other site 698964001287 D-loop; other site 698964001288 H-loop/switch region; other site 698964001289 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698964001290 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698964001291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698964001292 dimer interface [polypeptide binding]; other site 698964001293 conserved gate region; other site 698964001294 putative PBP binding loops; other site 698964001295 ABC-ATPase subunit interface; other site 698964001296 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 698964001297 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698964001298 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 698964001299 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698964001300 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698964001301 DNA-binding site [nucleotide binding]; DNA binding site 698964001302 FCD domain; Region: FCD; pfam07729 698964001303 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698964001304 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698964001305 nucleotide binding site [chemical binding]; other site 698964001306 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 698964001307 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 698964001308 putative active site cavity [active] 698964001309 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 698964001310 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 698964001311 active site 698964001312 dimer interface [polypeptide binding]; other site 698964001313 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 698964001314 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 698964001315 active site 698964001316 trimer interface [polypeptide binding]; other site 698964001317 allosteric site; other site 698964001318 active site lid [active] 698964001319 hexamer (dimer of trimers) interface [polypeptide binding]; other site 698964001320 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 698964001321 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 698964001322 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 698964001323 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 698964001324 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 698964001325 5S rRNA interface [nucleotide binding]; other site 698964001326 L27 interface [polypeptide binding]; other site 698964001327 23S rRNA interface [nucleotide binding]; other site 698964001328 L5 interface [polypeptide binding]; other site 698964001329 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 698964001330 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 698964001331 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 698964001332 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 698964001333 23S rRNA binding site [nucleotide binding]; other site 698964001334 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 698964001335 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 698964001336 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 698964001337 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 698964001338 active site 698964001339 catalytic site [active] 698964001340 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698964001341 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 698964001342 active site 698964001343 catalytic site [active] 698964001344 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 698964001345 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698964001346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698964001347 dimer interface [polypeptide binding]; other site 698964001348 conserved gate region; other site 698964001349 putative PBP binding loops; other site 698964001350 ABC-ATPase subunit interface; other site 698964001351 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698964001352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698964001353 dimer interface [polypeptide binding]; other site 698964001354 conserved gate region; other site 698964001355 putative PBP binding loops; other site 698964001356 ABC-ATPase subunit interface; other site 698964001357 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 698964001358 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698964001359 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698964001360 Walker A/P-loop; other site 698964001361 ATP binding site [chemical binding]; other site 698964001362 Q-loop/lid; other site 698964001363 ABC transporter signature motif; other site 698964001364 Walker B; other site 698964001365 D-loop; other site 698964001366 H-loop/switch region; other site 698964001367 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 698964001368 SecY translocase; Region: SecY; pfam00344 698964001369 adenylate kinase; Reviewed; Region: adk; PRK00279 698964001370 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 698964001371 AMP-binding site [chemical binding]; other site 698964001372 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 698964001373 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 698964001374 active site 698964001375 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 698964001376 catalytic site [active] 698964001377 BNR repeat-like domain; Region: BNR_2; pfam13088 698964001378 Asp-box motif; other site 698964001379 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698964001380 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 698964001381 rRNA binding site [nucleotide binding]; other site 698964001382 predicted 30S ribosome binding site; other site 698964001383 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 698964001384 30S ribosomal protein S13; Region: bact_S13; TIGR03631 698964001385 30S ribosomal protein S11; Validated; Region: PRK05309 698964001386 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 698964001387 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 698964001388 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698964001389 RNA binding surface [nucleotide binding]; other site 698964001390 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 698964001391 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 698964001392 alphaNTD - beta interaction site [polypeptide binding]; other site 698964001393 alphaNTD homodimer interface [polypeptide binding]; other site 698964001394 alphaNTD - beta' interaction site [polypeptide binding]; other site 698964001395 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 698964001396 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 698964001397 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 698964001398 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 698964001399 dimerization interface 3.5A [polypeptide binding]; other site 698964001400 active site 698964001401 Protein of unknown function (DUF690); Region: DUF690; cl04939 698964001402 TIGR02611 family protein; Region: TIGR02611 698964001403 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 698964001404 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 698964001405 active site 698964001406 catalytic residues [active] 698964001407 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 698964001408 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 698964001409 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698964001410 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 698964001411 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698964001412 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698964001413 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 698964001414 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 698964001415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 698964001416 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 698964001417 23S rRNA interface [nucleotide binding]; other site 698964001418 L3 interface [polypeptide binding]; other site 698964001419 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 698964001420 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 698964001421 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 698964001422 active site 698964001423 substrate binding site [chemical binding]; other site 698964001424 metal binding site [ion binding]; metal-binding site 698964001425 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 698964001426 alanine racemase; Reviewed; Region: alr; PRK00053 698964001427 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 698964001428 active site 698964001429 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698964001430 dimer interface [polypeptide binding]; other site 698964001431 substrate binding site [chemical binding]; other site 698964001432 catalytic residues [active] 698964001433 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 698964001434 Predicted permease [General function prediction only]; Region: COG2985 698964001435 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 698964001436 TrkA-C domain; Region: TrkA_C; pfam02080 698964001437 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 698964001438 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 698964001439 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 698964001440 Glycoprotease family; Region: Peptidase_M22; pfam00814 698964001441 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 698964001442 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698964001443 Coenzyme A binding pocket [chemical binding]; other site 698964001444 UGMP family protein; Validated; Region: PRK09604 698964001445 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 698964001446 oligomerisation interface [polypeptide binding]; other site 698964001447 mobile loop; other site 698964001448 roof hairpin; other site 698964001449 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 698964001450 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 698964001451 ring oligomerisation interface [polypeptide binding]; other site 698964001452 ATP/Mg binding site [chemical binding]; other site 698964001453 stacking interactions; other site 698964001454 hinge regions; other site 698964001455 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 698964001456 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698964001457 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698964001458 DNA binding residues [nucleotide binding] 698964001459 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 698964001460 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698964001461 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 698964001462 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 698964001463 active site 698964001464 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 698964001465 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698964001466 phosphate binding site [ion binding]; other site 698964001467 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698964001468 siderophore binding site; other site 698964001469 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698964001470 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698964001471 dimer interface [polypeptide binding]; other site 698964001472 putative PBP binding regions; other site 698964001473 ABC-ATPase subunit interface; other site 698964001474 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698964001475 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698964001476 ABC-ATPase subunit interface; other site 698964001477 dimer interface [polypeptide binding]; other site 698964001478 putative PBP binding regions; other site 698964001479 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698964001480 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698964001481 Walker A/P-loop; other site 698964001482 ATP binding site [chemical binding]; other site 698964001483 Q-loop/lid; other site 698964001484 ABC transporter signature motif; other site 698964001485 Walker B; other site 698964001486 D-loop; other site 698964001487 H-loop/switch region; other site 698964001488 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 698964001489 EamA-like transporter family; Region: EamA; pfam00892 698964001490 GMP synthase; Reviewed; Region: guaA; PRK00074 698964001491 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 698964001492 AMP/PPi binding site [chemical binding]; other site 698964001493 candidate oxyanion hole; other site 698964001494 catalytic triad [active] 698964001495 potential glutamine specificity residues [chemical binding]; other site 698964001496 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 698964001497 ATP Binding subdomain [chemical binding]; other site 698964001498 Ligand Binding sites [chemical binding]; other site 698964001499 Dimerization subdomain; other site 698964001500 PspC domain; Region: PspC; pfam04024 698964001501 PspC domain; Region: PspC; pfam04024 698964001502 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698964001503 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 698964001504 ATP binding site [chemical binding]; other site 698964001505 Mg2+ binding site [ion binding]; other site 698964001506 G-X-G motif; other site 698964001507 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698964001508 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698964001509 active site 698964001510 phosphorylation site [posttranslational modification] 698964001511 intermolecular recognition site; other site 698964001512 dimerization interface [polypeptide binding]; other site 698964001513 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698964001514 DNA binding residues [nucleotide binding] 698964001515 dimerization interface [polypeptide binding]; other site 698964001516 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698964001517 intersubunit interface [polypeptide binding]; other site 698964001518 DNA Polymerase Y-family; Region: PolY_like; cd03468 698964001519 active site 698964001520 DNA binding site [nucleotide binding] 698964001521 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 698964001522 putative dimer interface [polypeptide binding]; other site 698964001523 putative [2Fe-2S] cluster binding site [ion binding]; other site 698964001524 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698964001525 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 698964001526 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698964001527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698964001528 dimer interface [polypeptide binding]; other site 698964001529 conserved gate region; other site 698964001530 ABC-ATPase subunit interface; other site 698964001531 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 698964001532 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 698964001533 Walker A/P-loop; other site 698964001534 ATP binding site [chemical binding]; other site 698964001535 Q-loop/lid; other site 698964001536 ABC transporter signature motif; other site 698964001537 Walker B; other site 698964001538 D-loop; other site 698964001539 H-loop/switch region; other site 698964001540 NIL domain; Region: NIL; cl09633 698964001541 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 698964001542 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 698964001543 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 698964001544 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 698964001545 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 698964001546 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 698964001547 active site 698964001548 PHP Thumb interface [polypeptide binding]; other site 698964001549 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 698964001550 generic binding surface II; other site 698964001551 generic binding surface I; other site 698964001552 Uncharacterized conserved protein [Function unknown]; Region: COG3402 698964001553 Predicted membrane protein [Function unknown]; Region: COG3428 698964001554 Bacterial PH domain; Region: DUF304; pfam03703 698964001555 Bacterial PH domain; Region: DUF304; pfam03703 698964001556 Bacterial PH domain; Region: DUF304; pfam03703 698964001557 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698964001558 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698964001559 intersubunit interface [polypeptide binding]; other site 698964001560 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698964001561 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698964001562 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698964001563 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698964001564 dimer interface [polypeptide binding]; other site 698964001565 putative PBP binding regions; other site 698964001566 ABC-ATPase subunit interface; other site 698964001567 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698964001568 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698964001569 ABC-ATPase subunit interface; other site 698964001570 dimer interface [polypeptide binding]; other site 698964001571 putative PBP binding regions; other site 698964001572 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 698964001573 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 698964001574 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 698964001575 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 698964001576 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 698964001577 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 698964001578 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 698964001579 homodimer interface [polypeptide binding]; other site 698964001580 NADP binding site [chemical binding]; other site 698964001581 substrate binding site [chemical binding]; other site 698964001582 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 698964001583 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698964001584 active site 698964001585 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 698964001586 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 698964001587 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698964001588 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 698964001589 intersubunit interface [polypeptide binding]; other site 698964001590 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698964001591 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698964001592 ABC-ATPase subunit interface; other site 698964001593 dimer interface [polypeptide binding]; other site 698964001594 putative PBP binding regions; other site 698964001595 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 698964001596 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698964001597 Walker A/P-loop; other site 698964001598 ATP binding site [chemical binding]; other site 698964001599 Q-loop/lid; other site 698964001600 ABC transporter signature motif; other site 698964001601 Walker B; other site 698964001602 D-loop; other site 698964001603 H-loop/switch region; other site 698964001604 Htaa; Region: HtaA; pfam04213 698964001605 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05613 698964001606 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 698964001607 homodimer interface [polypeptide binding]; other site 698964001608 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698964001609 substrate-cofactor binding pocket; other site 698964001610 catalytic residue [active] 698964001611 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 698964001612 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 698964001613 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 698964001614 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698964001615 putative substrate translocation pore; other site 698964001616 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 698964001617 putative catalytic site [active] 698964001618 putative metal binding site [ion binding]; other site 698964001619 putative phosphate binding site [ion binding]; other site 698964001620 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 698964001621 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 698964001622 active site 698964001623 HIGH motif; other site 698964001624 dimer interface [polypeptide binding]; other site 698964001625 KMSKS motif; other site 698964001626 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 698964001627 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 698964001628 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 698964001629 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698964001630 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698964001631 NlpC/P60 family; Region: NLPC_P60; pfam00877 698964001632 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698964001633 active site 698964001634 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698964001635 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698964001636 non-specific DNA binding site [nucleotide binding]; other site 698964001637 salt bridge; other site 698964001638 sequence-specific DNA binding site [nucleotide binding]; other site 698964001639 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698964001640 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 698964001641 metal binding site [ion binding]; metal-binding site 698964001642 putative dimer interface [polypeptide binding]; other site 698964001643 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 698964001644 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698964001645 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698964001646 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698964001647 pyruvate carboxylase; Reviewed; Region: PRK12999 698964001648 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698964001649 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698964001650 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 698964001651 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 698964001652 active site 698964001653 catalytic residues [active] 698964001654 metal binding site [ion binding]; metal-binding site 698964001655 homodimer binding site [polypeptide binding]; other site 698964001656 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698964001657 carboxyltransferase (CT) interaction site; other site 698964001658 biotinylation site [posttranslational modification]; other site 698964001659 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749 698964001660 ADP-ribose binding site [chemical binding]; other site 698964001661 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 698964001662 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698964001663 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 698964001664 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 698964001665 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698964001666 carboxyltransferase (CT) interaction site; other site 698964001667 biotinylation site [posttranslational modification]; other site 698964001668 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 698964001669 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698964001670 active site residue [active] 698964001671 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 698964001672 active site residue [active] 698964001673 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698964001674 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 698964001675 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 698964001676 active site 698964001677 dimer interface [polypeptide binding]; other site 698964001678 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 698964001679 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698964001680 substrate binding site [chemical binding]; other site 698964001681 dimer interface [polypeptide binding]; other site 698964001682 ATP binding site [chemical binding]; other site 698964001683 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698964001684 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698964001685 DNA binding site [nucleotide binding] 698964001686 domain linker motif; other site 698964001687 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 698964001688 dimerization interface [polypeptide binding]; other site 698964001689 putative ligand binding site [chemical binding]; other site 698964001690 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 698964001691 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698964001692 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698964001693 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698964001694 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698964001695 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698964001696 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698964001697 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 698964001698 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 698964001699 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 698964001700 ATP-grasp domain; Region: ATP-grasp; pfam02222 698964001701 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 698964001702 Uncharacterized conserved protein [Function unknown]; Region: COG1434 698964001703 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 698964001704 putative active site [active] 698964001705 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 698964001706 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 698964001707 HupF/HypC family; Region: HupF_HypC; pfam01455 698964001708 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 698964001709 dimerization interface [polypeptide binding]; other site 698964001710 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 698964001711 ATP binding site [chemical binding]; other site 698964001712 Acylphosphatase; Region: Acylphosphatase; pfam00708 698964001713 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 698964001714 HypF finger; Region: zf-HYPF; pfam07503 698964001715 HypF finger; Region: zf-HYPF; pfam07503 698964001716 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 698964001717 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 698964001718 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 698964001719 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698964001720 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 698964001721 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 698964001722 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 698964001723 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 698964001724 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 698964001725 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 698964001726 putative substrate-binding site; other site 698964001727 nickel binding site [ion binding]; other site 698964001728 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 698964001729 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 698964001730 HupF/HypC family; Region: HupF_HypC; pfam01455 698964001731 TIGR03089 family protein; Region: TIGR03089 698964001732 Transcriptional regulator [Transcription]; Region: LytR; COG1316 698964001733 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 698964001734 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 698964001735 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698964001736 active site 698964001737 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698964001738 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 698964001739 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 698964001740 active site 698964001741 Substrate binding site; other site 698964001742 Mg++ binding site; other site 698964001743 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698964001744 putative trimer interface [polypeptide binding]; other site 698964001745 putative CoA binding site [chemical binding]; other site 698964001746 Transcription factor WhiB; Region: Whib; pfam02467 698964001747 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 698964001748 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 698964001749 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 698964001750 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 698964001751 active site 698964001752 substrate binding site [chemical binding]; other site 698964001753 metal binding site [ion binding]; metal-binding site 698964001754 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 698964001755 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 698964001756 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 698964001757 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 698964001758 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 698964001759 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 698964001760 homotetramer interface [polypeptide binding]; other site 698964001761 ligand binding site [chemical binding]; other site 698964001762 catalytic site [active] 698964001763 NAD binding site [chemical binding]; other site 698964001764 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 698964001765 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 698964001766 TMP-binding site; other site 698964001767 ATP-binding site [chemical binding]; other site 698964001768 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698964001769 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698964001770 active site 698964001771 phosphorylation site [posttranslational modification] 698964001772 intermolecular recognition site; other site 698964001773 dimerization interface [polypeptide binding]; other site 698964001774 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698964001775 DNA binding site [nucleotide binding] 698964001776 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698964001777 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698964001778 dimerization interface [polypeptide binding]; other site 698964001779 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698964001780 dimer interface [polypeptide binding]; other site 698964001781 phosphorylation site [posttranslational modification] 698964001782 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698964001783 Mg2+ binding site [ion binding]; other site 698964001784 G-X-G motif; other site 698964001785 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698964001786 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698964001787 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698964001788 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698964001789 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698964001790 non-specific DNA binding site [nucleotide binding]; other site 698964001791 salt bridge; other site 698964001792 sequence-specific DNA binding site [nucleotide binding]; other site 698964001793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698964001794 ATP binding site [chemical binding]; other site 698964001795 G-X-G motif; other site 698964001796 lipoprotein LpqB; Provisional; Region: PRK13616 698964001797 Sporulation and spore germination; Region: Germane; pfam10646 698964001798 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 698964001799 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698964001800 active site 698964001801 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 698964001802 30S subunit binding site; other site 698964001803 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 698964001804 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698964001805 ATP binding site [chemical binding]; other site 698964001806 putative Mg++ binding site [ion binding]; other site 698964001807 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 698964001808 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698964001809 nucleotide binding region [chemical binding]; other site 698964001810 ATP-binding site [chemical binding]; other site 698964001811 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 698964001812 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 698964001813 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 698964001814 FAD binding pocket [chemical binding]; other site 698964001815 FAD binding motif [chemical binding]; other site 698964001816 phosphate binding motif [ion binding]; other site 698964001817 beta-alpha-beta structure motif; other site 698964001818 NAD binding pocket [chemical binding]; other site 698964001819 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698964001820 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 698964001821 catalytic loop [active] 698964001822 iron binding site [ion binding]; other site 698964001823 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 698964001824 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 698964001825 putative di-iron ligands [ion binding]; other site 698964001826 Predicted GTPases [General function prediction only]; Region: COG1162 698964001827 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 698964001828 GTPase/Zn-binding domain interface [polypeptide binding]; other site 698964001829 GTP/Mg2+ binding site [chemical binding]; other site 698964001830 G4 box; other site 698964001831 G5 box; other site 698964001832 G1 box; other site 698964001833 Switch I region; other site 698964001834 G2 box; other site 698964001835 G3 box; other site 698964001836 Switch II region; other site 698964001837 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 698964001838 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 698964001839 hinge; other site 698964001840 active site 698964001841 Uncharacterized conserved protein [Function unknown]; Region: COG2135 698964001842 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 698964001843 putative deacylase active site [active] 698964001844 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 698964001845 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698964001846 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698964001847 DNA binding residues [nucleotide binding] 698964001848 Transcription factor WhiB; Region: Whib; pfam02467 698964001849 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698964001850 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698964001851 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698964001852 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698964001853 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698964001854 non-specific DNA binding site [nucleotide binding]; other site 698964001855 salt bridge; other site 698964001856 sequence-specific DNA binding site [nucleotide binding]; other site 698964001857 PQQ-like domain; Region: PQQ_2; pfam13360 698964001858 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 698964001859 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698964001860 ATP binding site [chemical binding]; other site 698964001861 Mg++ binding site [ion binding]; other site 698964001862 motif III; other site 698964001863 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698964001864 nucleotide binding region [chemical binding]; other site 698964001865 ATP-binding site [chemical binding]; other site 698964001866 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 698964001867 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 698964001868 TIGR02569 family protein; Region: TIGR02569_actnb 698964001869 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698964001870 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 698964001871 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 698964001872 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698964001873 Part of AAA domain; Region: AAA_19; pfam13245 698964001874 Family description; Region: UvrD_C_2; pfam13538 698964001875 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 698964001876 Ion channel; Region: Ion_trans_2; pfam07885 698964001877 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 698964001878 TrkA-N domain; Region: TrkA_N; pfam02254 698964001879 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 698964001880 putative NADH binding site [chemical binding]; other site 698964001881 putative active site [active] 698964001882 nudix motif; other site 698964001883 putative metal binding site [ion binding]; other site 698964001884 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 698964001885 Part of AAA domain; Region: AAA_19; pfam13245 698964001886 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698964001887 Family description; Region: UvrD_C_2; pfam13538 698964001888 HRDC domain; Region: HRDC; pfam00570 698964001889 Protein of unknown function DUF45; Region: DUF45; pfam01863 698964001890 putative hydrolase; Region: TIGR03624 698964001891 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 698964001892 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698964001893 hypothetical protein; Validated; Region: PRK00068 698964001894 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 698964001895 HsdM N-terminal domain; Region: HsdM_N; pfam12161 698964001896 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 698964001897 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698964001898 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698964001899 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 698964001900 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698964001901 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 698964001902 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 698964001903 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698964001904 ATP binding site [chemical binding]; other site 698964001905 putative Mg++ binding site [ion binding]; other site 698964001906 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698964001907 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698964001908 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698964001909 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698964001910 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698964001911 non-specific DNA binding site [nucleotide binding]; other site 698964001912 salt bridge; other site 698964001913 sequence-specific DNA binding site [nucleotide binding]; other site 698964001914 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 698964001915 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 698964001916 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 698964001917 Presynaptic Site I dimer interface [polypeptide binding]; other site 698964001918 catalytic residues [active] 698964001919 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 698964001920 Synaptic Flat tetramer interface [polypeptide binding]; other site 698964001921 Synaptic Site I dimer interface [polypeptide binding]; other site 698964001922 DNA binding site [nucleotide binding] 698964001923 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 698964001924 DNA-binding interface [nucleotide binding]; DNA binding site 698964001925 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 698964001926 active site 698964001927 Protein of unknown function (DUF418); Region: DUF418; cl12135 698964001928 oxaloacetate decarboxylase; Provisional; Region: PRK12330 698964001929 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 698964001930 active site 698964001931 catalytic residues [active] 698964001932 metal binding site [ion binding]; metal-binding site 698964001933 homodimer binding site [polypeptide binding]; other site 698964001934 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 698964001935 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698964001936 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698964001937 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698964001938 carboxyltransferase (CT) interaction site; other site 698964001939 biotinylation site [posttranslational modification]; other site 698964001940 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698964001941 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 698964001942 active site 698964001943 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 698964001944 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698964001945 active site 698964001946 peptide chain release factor 2; Validated; Region: prfB; PRK00578 698964001947 This domain is found in peptide chain release factors; Region: PCRF; smart00937 698964001948 RF-1 domain; Region: RF-1; pfam00472 698964001949 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 698964001950 AbgT putative transporter family; Region: ABG_transport; cl17431 698964001951 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 698964001952 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698964001953 Walker A/P-loop; other site 698964001954 ATP binding site [chemical binding]; other site 698964001955 Q-loop/lid; other site 698964001956 ABC transporter signature motif; other site 698964001957 Walker B; other site 698964001958 D-loop; other site 698964001959 H-loop/switch region; other site 698964001960 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 698964001961 FtsX-like permease family; Region: FtsX; pfam02687 698964001962 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 698964001963 SmpB-tmRNA interface; other site 698964001964 Cupin domain; Region: Cupin_2; cl17218 698964001965 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 698964001966 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698964001967 S-adenosylmethionine binding site [chemical binding]; other site 698964001968 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698964001969 Winged helix-turn helix; Region: HTH_29; pfam13551 698964001970 Helix-turn-helix domain; Region: HTH_28; pfam13518 698964001971 putative transposase OrfB; Reviewed; Region: PHA02517 698964001972 HTH-like domain; Region: HTH_21; pfam13276 698964001973 Integrase core domain; Region: rve; pfam00665 698964001974 Integrase core domain; Region: rve_2; pfam13333 698964001975 potential frameshift: common BLAST hit: gi|262201194|ref|YP_003272402.1| class I/II aminotransferase 698964001976 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698964001977 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698964001978 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 698964001979 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 698964001980 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698964001981 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698964001982 nucleotide binding region [chemical binding]; other site 698964001983 ATP-binding site [chemical binding]; other site 698964001984 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 698964001985 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 698964001986 Protein of unknown function (DUF3235); Region: DUF3235; pfam11574 698964001987 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698964001988 DNA-binding site [nucleotide binding]; DNA binding site 698964001989 RNA-binding motif; other site 698964001990 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 698964001991 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 698964001992 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 698964001993 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 698964001994 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698964001995 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698964001996 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 698964001997 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698964001998 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698964001999 catalytic residue [active] 698964002000 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 698964002001 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 698964002002 dimer interface [polypeptide binding]; other site 698964002003 active site 698964002004 citrylCoA binding site [chemical binding]; other site 698964002005 NADH binding [chemical binding]; other site 698964002006 cationic pore residues; other site 698964002007 oxalacetate/citrate binding site [chemical binding]; other site 698964002008 coenzyme A binding site [chemical binding]; other site 698964002009 catalytic triad [active] 698964002010 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 698964002011 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 698964002012 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698964002013 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698964002014 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698964002015 active site 698964002016 catalytic tetrad [active] 698964002017 potential frameshift: common BLAST hit: gi|38233388|ref|NP_939155.1| enoyl-CoA hydratase 698964002018 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 698964002019 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698964002020 substrate binding site [chemical binding]; other site 698964002021 oxyanion hole (OAH) forming residues; other site 698964002022 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698964002023 trimer interface [polypeptide binding]; other site 698964002024 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 698964002025 Protein of unknown function, DUF485; Region: DUF485; pfam04341 698964002026 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 698964002027 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 698964002028 Na binding site [ion binding]; other site 698964002029 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 698964002030 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 698964002031 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 698964002032 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 698964002033 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 698964002034 active site 698964002035 SAM binding site [chemical binding]; other site 698964002036 homodimer interface [polypeptide binding]; other site 698964002037 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 698964002038 catalytic residues [active] 698964002039 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 698964002040 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 698964002041 folate binding site [chemical binding]; other site 698964002042 NADP+ binding site [chemical binding]; other site 698964002043 thymidylate synthase; Reviewed; Region: thyA; PRK01827 698964002044 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 698964002045 dimerization interface [polypeptide binding]; other site 698964002046 active site 698964002047 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 698964002048 active site 698964002049 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698964002050 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 698964002051 ATP binding site [chemical binding]; other site 698964002052 putative Mg++ binding site [ion binding]; other site 698964002053 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698964002054 nucleotide binding region [chemical binding]; other site 698964002055 ATP-binding site [chemical binding]; other site 698964002056 DEAD/H associated; Region: DEAD_assoc; pfam08494 698964002057 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 698964002058 active site 698964002059 SUMO-1 interface [polypeptide binding]; other site 698964002060 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 698964002061 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 698964002062 putative DNA binding site [nucleotide binding]; other site 698964002063 catalytic residue [active] 698964002064 putative H2TH interface [polypeptide binding]; other site 698964002065 putative catalytic residues [active] 698964002066 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698964002067 Predicted permease [General function prediction only]; Region: COG2985 698964002068 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 698964002069 TrkA-C domain; Region: TrkA_C; pfam02080 698964002070 TrkA-C domain; Region: TrkA_C; pfam02080 698964002071 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 698964002072 hypothetical protein; Provisional; Region: PRK11770 698964002073 Domain of unknown function (DUF307); Region: DUF307; pfam03733 698964002074 Domain of unknown function (DUF307); Region: DUF307; pfam03733 698964002075 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 698964002076 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 698964002077 active site 698964002078 dimer interface [polypeptide binding]; other site 698964002079 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 698964002080 dimer interface [polypeptide binding]; other site 698964002081 active site 698964002082 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698964002083 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 698964002084 tetramerization interface [polypeptide binding]; other site 698964002085 NAD(P) binding site [chemical binding]; other site 698964002086 catalytic residues [active] 698964002087 hypothetical protein; Provisional; Region: PRK07857 698964002088 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 698964002089 Part of AAA domain; Region: AAA_19; pfam13245 698964002090 Family description; Region: UvrD_C_2; pfam13538 698964002091 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 698964002092 Peptidase family M23; Region: Peptidase_M23; pfam01551 698964002093 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 698964002094 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 698964002095 active site 698964002096 substrate binding site [chemical binding]; other site 698964002097 cosubstrate binding site; other site 698964002098 catalytic site [active] 698964002099 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 698964002100 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 698964002101 purine monophosphate binding site [chemical binding]; other site 698964002102 dimer interface [polypeptide binding]; other site 698964002103 putative catalytic residues [active] 698964002104 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 698964002105 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 698964002106 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698964002107 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698964002108 Domain of unknown function (DUF2014); Region: DUF2014; pfam09427 698964002109 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 698964002110 30S ribosomal protein S18; Provisional; Region: PRK13401 698964002111 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 698964002112 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 698964002113 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 698964002114 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 698964002115 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 698964002116 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698964002117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698964002118 active site 698964002119 phosphorylation site [posttranslational modification] 698964002120 intermolecular recognition site; other site 698964002121 dimerization interface [polypeptide binding]; other site 698964002122 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698964002123 DNA binding site [nucleotide binding] 698964002124 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 698964002125 dimerization interface [polypeptide binding]; other site 698964002126 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698964002127 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698964002128 dimer interface [polypeptide binding]; other site 698964002129 phosphorylation site [posttranslational modification] 698964002130 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698964002131 ATP binding site [chemical binding]; other site 698964002132 Mg2+ binding site [ion binding]; other site 698964002133 G-X-G motif; other site 698964002134 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 698964002135 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698964002136 protein binding site [polypeptide binding]; other site 698964002137 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698964002138 MPT binding site; other site 698964002139 trimer interface [polypeptide binding]; other site 698964002140 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 698964002141 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 698964002142 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 698964002143 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 698964002144 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 698964002145 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 698964002146 active site 698964002147 tetramer interface; other site 698964002148 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 698964002149 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 698964002150 dimer interface [polypeptide binding]; other site 698964002151 putative functional site; other site 698964002152 putative MPT binding site; other site 698964002153 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698964002154 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698964002155 Predicted membrane protein [Function unknown]; Region: COG2259 698964002156 Predicted integral membrane protein [Function unknown]; Region: COG5660 698964002157 Putative zinc-finger; Region: zf-HC2; pfam13490 698964002158 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 698964002159 BCCT family transporter; Region: BCCT; pfam02028 698964002160 Uncharacterized membrane protein [Function unknown]; Region: COG3949 698964002161 Predicted methyltransferases [General function prediction only]; Region: COG0313 698964002162 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 698964002163 putative SAM binding site [chemical binding]; other site 698964002164 putative homodimer interface [polypeptide binding]; other site 698964002165 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 698964002166 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 698964002167 active site 698964002168 HIGH motif; other site 698964002169 KMSKS motif; other site 698964002170 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 698964002171 tRNA binding surface [nucleotide binding]; other site 698964002172 anticodon binding site; other site 698964002173 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 698964002174 active site 698964002175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 698964002176 Domain of unknown function (DUF348); Region: DUF348; pfam03990 698964002177 Domain of unknown function (DUF348); Region: DUF348; pfam03990 698964002178 Domain of unknown function (DUF348); Region: DUF348; pfam03990 698964002179 G5 domain; Region: G5; pfam07501 698964002180 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 698964002181 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 698964002182 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698964002183 S-adenosylmethionine binding site [chemical binding]; other site 698964002184 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 698964002185 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 698964002186 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698964002187 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698964002188 ABC transporter; Region: ABC_tran_2; pfam12848 698964002189 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698964002190 Uncharacterized conserved protein [Function unknown]; Region: COG1359 698964002191 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 698964002192 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698964002193 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698964002194 DNA binding residues [nucleotide binding] 698964002195 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 698964002196 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 698964002197 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698964002198 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698964002199 active site 698964002200 motif I; other site 698964002201 motif II; other site 698964002202 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 698964002203 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 698964002204 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698964002205 substrate binding site [chemical binding]; other site 698964002206 oxyanion hole (OAH) forming residues; other site 698964002207 trimer interface [polypeptide binding]; other site 698964002208 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 698964002209 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698964002210 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698964002211 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 698964002212 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 698964002213 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 698964002214 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 698964002215 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 698964002216 G1 box; other site 698964002217 putative GEF interaction site [polypeptide binding]; other site 698964002218 GTP/Mg2+ binding site [chemical binding]; other site 698964002219 Switch I region; other site 698964002220 G2 box; other site 698964002221 G3 box; other site 698964002222 Switch II region; other site 698964002223 G4 box; other site 698964002224 G5 box; other site 698964002225 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 698964002226 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698964002227 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 698964002228 NAD(P) binding site [chemical binding]; other site 698964002229 active site 698964002230 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 698964002231 putative active site [active] 698964002232 catalytic residue [active] 698964002233 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698964002234 active site 698964002235 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 698964002236 putative active site [active] 698964002237 catalytic residue [active] 698964002238 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 698964002239 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 698964002240 5S rRNA interface [nucleotide binding]; other site 698964002241 CTC domain interface [polypeptide binding]; other site 698964002242 L16 interface [polypeptide binding]; other site 698964002243 pullulanase, type I; Region: pulA_typeI; TIGR02104 698964002244 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 698964002245 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 698964002246 Ca binding site [ion binding]; other site 698964002247 active site 698964002248 catalytic site [active] 698964002249 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 698964002250 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 698964002251 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698964002252 active site 698964002253 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 698964002254 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 698964002255 Substrate binding site; other site 698964002256 Mg++ binding site; other site 698964002257 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 698964002258 active site 698964002259 substrate binding site [chemical binding]; other site 698964002260 CoA binding site [chemical binding]; other site 698964002261 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698964002262 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698964002263 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 698964002264 putative dimerization interface [polypeptide binding]; other site 698964002265 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 698964002266 gating phenylalanine in ion channel; other site 698964002267 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 698964002268 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 698964002269 putative ligand binding site [chemical binding]; other site 698964002270 putative NAD binding site [chemical binding]; other site 698964002271 catalytic site [active] 698964002272 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698964002273 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698964002274 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698964002275 Q-loop/lid; other site 698964002276 ABC transporter signature motif; other site 698964002277 Walker B; other site 698964002278 D-loop; other site 698964002279 H-loop/switch region; other site 698964002280 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698964002281 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698964002282 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698964002283 Walker A/P-loop; other site 698964002284 ATP binding site [chemical binding]; other site 698964002285 Q-loop/lid; other site 698964002286 ABC transporter signature motif; other site 698964002287 Walker B; other site 698964002288 D-loop; other site 698964002289 H-loop/switch region; other site 698964002290 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698964002291 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698964002292 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 698964002293 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 698964002294 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698964002295 ATP binding site [chemical binding]; other site 698964002296 putative Mg++ binding site [ion binding]; other site 698964002297 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698964002298 nucleotide binding region [chemical binding]; other site 698964002299 ATP-binding site [chemical binding]; other site 698964002300 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 698964002301 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 698964002302 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 698964002303 homodimer interface [polypeptide binding]; other site 698964002304 metal binding site [ion binding]; metal-binding site 698964002305 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 698964002306 enolase; Provisional; Region: eno; PRK00077 698964002307 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 698964002308 dimer interface [polypeptide binding]; other site 698964002309 metal binding site [ion binding]; metal-binding site 698964002310 substrate binding pocket [chemical binding]; other site 698964002311 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 698964002312 Septum formation initiator; Region: DivIC; pfam04977 698964002313 Uncharacterized conserved protein [Function unknown]; Region: COG1507 698964002314 exopolyphosphatase; Region: exo_poly_only; TIGR03706 698964002315 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 698964002316 Helix-turn-helix domain; Region: HTH_18; pfam12833 698964002317 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698964002318 Bax inhibitor 1 like; Region: BaxI_1; cl17691 698964002319 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 698964002320 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 698964002321 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 698964002322 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 698964002323 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 698964002324 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 698964002325 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 698964002326 catalytic residue [active] 698964002327 putative FPP diphosphate binding site; other site 698964002328 putative FPP binding hydrophobic cleft; other site 698964002329 dimer interface [polypeptide binding]; other site 698964002330 putative IPP diphosphate binding site; other site 698964002331 Flavodoxin domain; Region: Flavodoxin_5; cl17428 698964002332 pantothenate kinase; Provisional; Region: PRK05439 698964002333 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 698964002334 ATP-binding site [chemical binding]; other site 698964002335 CoA-binding site [chemical binding]; other site 698964002336 Mg2+-binding site [ion binding]; other site 698964002337 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 698964002338 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 698964002339 dimer interface [polypeptide binding]; other site 698964002340 active site 698964002341 glycine-pyridoxal phosphate binding site [chemical binding]; other site 698964002342 folate binding site [chemical binding]; other site 698964002343 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698964002344 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 698964002345 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698964002346 Coenzyme A binding pocket [chemical binding]; other site 698964002347 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 698964002348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698964002349 putative substrate translocation pore; other site 698964002350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698964002351 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698964002352 fumarate hydratase; Reviewed; Region: fumC; PRK00485 698964002353 Class II fumarases; Region: Fumarase_classII; cd01362 698964002354 active site 698964002355 tetramer interface [polypeptide binding]; other site 698964002356 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 698964002357 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 698964002358 putative active site [active] 698964002359 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 698964002360 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 698964002361 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 698964002362 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 698964002363 generic binding surface II; other site 698964002364 generic binding surface I; other site 698964002365 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 698964002366 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 698964002367 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 698964002368 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698964002369 Domain of unknown function DUF20; Region: UPF0118; pfam01594 698964002370 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 698964002371 Na2 binding site [ion binding]; other site 698964002372 putative substrate binding site 1 [chemical binding]; other site 698964002373 Na binding site 1 [ion binding]; other site 698964002374 putative substrate binding site 2 [chemical binding]; other site 698964002375 GTP-binding protein YchF; Reviewed; Region: PRK09601 698964002376 YchF GTPase; Region: YchF; cd01900 698964002377 G1 box; other site 698964002378 GTP/Mg2+ binding site [chemical binding]; other site 698964002379 Switch I region; other site 698964002380 G2 box; other site 698964002381 Switch II region; other site 698964002382 G3 box; other site 698964002383 G4 box; other site 698964002384 G5 box; other site 698964002385 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 698964002386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 698964002387 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 698964002388 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 698964002389 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 698964002390 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 698964002391 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 698964002392 Cl- selectivity filter; other site 698964002393 Cl- binding residues [ion binding]; other site 698964002394 pore gating glutamate residue; other site 698964002395 dimer interface [polypeptide binding]; other site 698964002396 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698964002397 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698964002398 Walker A/P-loop; other site 698964002399 ATP binding site [chemical binding]; other site 698964002400 Q-loop/lid; other site 698964002401 ABC transporter signature motif; other site 698964002402 Walker B; other site 698964002403 D-loop; other site 698964002404 H-loop/switch region; other site 698964002405 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 698964002406 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698964002407 Walker A/P-loop; other site 698964002408 ATP binding site [chemical binding]; other site 698964002409 Q-loop/lid; other site 698964002410 ABC transporter signature motif; other site 698964002411 Walker B; other site 698964002412 D-loop; other site 698964002413 H-loop/switch region; other site 698964002414 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 698964002415 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 698964002416 active site 698964002417 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 698964002418 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698964002419 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698964002420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698964002421 dimer interface [polypeptide binding]; other site 698964002422 conserved gate region; other site 698964002423 ABC-ATPase subunit interface; other site 698964002424 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698964002425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698964002426 dimer interface [polypeptide binding]; other site 698964002427 conserved gate region; other site 698964002428 putative PBP binding loops; other site 698964002429 ABC-ATPase subunit interface; other site 698964002430 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698964002431 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698964002432 Walker A/P-loop; other site 698964002433 ATP binding site [chemical binding]; other site 698964002434 Q-loop/lid; other site 698964002435 ABC transporter signature motif; other site 698964002436 Walker B; other site 698964002437 D-loop; other site 698964002438 H-loop/switch region; other site 698964002439 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698964002440 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698964002441 Walker A/P-loop; other site 698964002442 ATP binding site [chemical binding]; other site 698964002443 Q-loop/lid; other site 698964002444 ABC transporter signature motif; other site 698964002445 Walker B; other site 698964002446 D-loop; other site 698964002447 H-loop/switch region; other site 698964002448 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698964002449 Predicted transcriptional regulators [Transcription]; Region: COG1695 698964002450 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 698964002451 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698964002452 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698964002453 Walker A/P-loop; other site 698964002454 ATP binding site [chemical binding]; other site 698964002455 Q-loop/lid; other site 698964002456 ABC transporter signature motif; other site 698964002457 Walker B; other site 698964002458 D-loop; other site 698964002459 H-loop/switch region; other site 698964002460 Trypsin; Region: Trypsin; pfam00089 698964002461 active site 698964002462 substrate binding sites [chemical binding]; other site 698964002463 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 698964002464 ArsC family; Region: ArsC; pfam03960 698964002465 catalytic residues [active] 698964002466 Protein of unknown function (DUF402); Region: DUF402; cl00979 698964002467 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 698964002468 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 698964002469 G1 box; other site 698964002470 GTP/Mg2+ binding site [chemical binding]; other site 698964002471 G2 box; other site 698964002472 Switch I region; other site 698964002473 G3 box; other site 698964002474 Switch II region; other site 698964002475 G4 box; other site 698964002476 G5 box; other site 698964002477 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 698964002478 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 698964002479 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 698964002480 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698964002481 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 698964002482 Ferredoxin [Energy production and conversion]; Region: COG1146 698964002483 4Fe-4S binding domain; Region: Fer4; pfam00037 698964002484 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 698964002485 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698964002486 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698964002487 homodimer interface [polypeptide binding]; other site 698964002488 catalytic residue [active] 698964002489 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 698964002490 active site 698964002491 Predicted membrane protein [Function unknown]; Region: COG2246 698964002492 GtrA-like protein; Region: GtrA; pfam04138 698964002493 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698964002494 active site 698964002495 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 698964002496 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 698964002497 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 698964002498 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 698964002499 putative trimer interface [polypeptide binding]; other site 698964002500 putative CoA binding site [chemical binding]; other site 698964002501 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 698964002502 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 698964002503 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536 698964002504 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698964002505 putative trimer interface [polypeptide binding]; other site 698964002506 putative CoA binding site [chemical binding]; other site 698964002507 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 698964002508 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 698964002509 metal binding site [ion binding]; metal-binding site 698964002510 putative dimer interface [polypeptide binding]; other site 698964002511 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 698964002512 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 698964002513 dihydropteroate synthase; Region: DHPS; TIGR01496 698964002514 substrate binding pocket [chemical binding]; other site 698964002515 dimer interface [polypeptide binding]; other site 698964002516 inhibitor binding site; inhibition site 698964002517 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 698964002518 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 698964002519 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 698964002520 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698964002521 S-adenosylmethionine binding site [chemical binding]; other site 698964002522 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 698964002523 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 698964002524 active site 698964002525 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 698964002526 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 698964002527 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 698964002528 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698964002529 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 698964002530 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 698964002531 ligand binding site; other site 698964002532 oligomer interface; other site 698964002533 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 698964002534 dimer interface [polypeptide binding]; other site 698964002535 N-terminal domain interface [polypeptide binding]; other site 698964002536 sulfate 1 binding site; other site 698964002537 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 698964002538 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698964002539 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 698964002540 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698964002541 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698964002542 DNA binding residues [nucleotide binding] 698964002543 Putative zinc-finger; Region: zf-HC2; pfam13490 698964002544 sec-independent translocase; Provisional; Region: tatB; PRK00182 698964002545 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 698964002546 Domain of unknown function DUF59; Region: DUF59; pfam01883 698964002547 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 698964002548 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 698964002549 Predicted membrane protein [Function unknown]; Region: COG4420 698964002550 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 698964002551 MgtE intracellular N domain; Region: MgtE_N; smart00924 698964002552 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 698964002553 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 698964002554 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 698964002555 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 698964002556 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 698964002557 TPP-binding site [chemical binding]; other site 698964002558 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 698964002559 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698964002560 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698964002561 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698964002562 Walker A/P-loop; other site 698964002563 ATP binding site [chemical binding]; other site 698964002564 Q-loop/lid; other site 698964002565 ABC transporter signature motif; other site 698964002566 Walker B; other site 698964002567 D-loop; other site 698964002568 H-loop/switch region; other site 698964002569 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698964002570 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698964002571 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698964002572 Walker A/P-loop; other site 698964002573 ATP binding site [chemical binding]; other site 698964002574 Q-loop/lid; other site 698964002575 ABC transporter signature motif; other site 698964002576 Walker B; other site 698964002577 D-loop; other site 698964002578 H-loop/switch region; other site 698964002579 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 698964002580 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 698964002581 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 698964002582 shikimate binding site; other site 698964002583 NAD(P) binding site [chemical binding]; other site 698964002584 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 698964002585 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 698964002586 substrate binding pocket [chemical binding]; other site 698964002587 catalytic triad [active] 698964002588 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 698964002589 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 698964002590 active site 698964002591 catalytic residues [active] 698964002592 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 698964002593 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 698964002594 Na binding site [ion binding]; other site 698964002595 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 698964002596 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 698964002597 nucleotide binding site/active site [active] 698964002598 HIT family signature motif; other site 698964002599 catalytic residue [active] 698964002600 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 698964002601 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 698964002602 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 698964002603 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 698964002604 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 698964002605 PLD-like domain; Region: PLDc_2; pfam13091 698964002606 putative homodimer interface [polypeptide binding]; other site 698964002607 putative active site [active] 698964002608 catalytic site [active] 698964002609 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698964002610 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 698964002611 putative Mg++ binding site [ion binding]; other site 698964002612 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698964002613 nucleotide binding region [chemical binding]; other site 698964002614 ATP-binding site [chemical binding]; other site 698964002615 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 698964002616 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 698964002617 active site 698964002618 8-oxo-dGMP binding site [chemical binding]; other site 698964002619 nudix motif; other site 698964002620 metal binding site [ion binding]; metal-binding site 698964002621 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 698964002622 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698964002623 ATP binding site [chemical binding]; other site 698964002624 Mg++ binding site [ion binding]; other site 698964002625 motif III; other site 698964002626 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698964002627 nucleotide binding region [chemical binding]; other site 698964002628 ATP-binding site [chemical binding]; other site 698964002629 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 698964002630 putative RNA binding site [nucleotide binding]; other site 698964002631 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 698964002632 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 698964002633 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 698964002634 Na binding site [ion binding]; other site 698964002635 SNF2 Helicase protein; Region: DUF3670; pfam12419 698964002636 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 698964002637 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698964002638 ATP binding site [chemical binding]; other site 698964002639 putative Mg++ binding site [ion binding]; other site 698964002640 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698964002641 nucleotide binding region [chemical binding]; other site 698964002642 ATP-binding site [chemical binding]; other site 698964002643 Uncharacterized conserved protein [Function unknown]; Region: COG4279 698964002644 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 698964002645 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 698964002646 active site 698964002647 metal binding site [ion binding]; metal-binding site 698964002648 DNA binding site [nucleotide binding] 698964002649 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 698964002650 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698964002651 Walker A/P-loop; other site 698964002652 ATP binding site [chemical binding]; other site 698964002653 Q-loop/lid; other site 698964002654 Uncharacterized conserved protein [Function unknown]; Region: COG2353 698964002655 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698964002656 MarR family; Region: MarR_2; pfam12802 698964002657 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 698964002658 potential frameshift: common BLAST hit: gi|62389924|ref|YP_225326.1| transposase 698964002659 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698964002660 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698964002661 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698964002662 Arginine degradation protein (predicted deacylase) [Amino acid transport and metabolism]; Region: RocB; COG4187 698964002663 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698964002664 dimerization interface [polypeptide binding]; other site 698964002665 putative DNA binding site [nucleotide binding]; other site 698964002666 putative Zn2+ binding site [ion binding]; other site 698964002667 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 698964002668 Cadmium resistance transporter; Region: Cad; pfam03596 698964002669 Homeodomain-like domain; Region: HTH_23; cl17451 698964002670 Helix-turn-helix domain; Region: HTH_28; pfam13518 698964002671 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 698964002672 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 698964002673 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 698964002674 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 698964002675 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 698964002676 Cysteine-rich domain; Region: CCG; pfam02754 698964002677 Cysteine-rich domain; Region: CCG; pfam02754 698964002678 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 698964002679 L-lactate permease; Region: Lactate_perm; cl00701 698964002680 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 698964002681 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 698964002682 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 698964002683 active site 698964002684 HIGH motif; other site 698964002685 KMSK motif region; other site 698964002686 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 698964002687 tRNA binding surface [nucleotide binding]; other site 698964002688 anticodon binding site; other site 698964002689 diaminopimelate decarboxylase; Region: lysA; TIGR01048 698964002690 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 698964002691 active site 698964002692 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698964002693 substrate binding site [chemical binding]; other site 698964002694 catalytic residues [active] 698964002695 dimer interface [polypeptide binding]; other site 698964002696 homoserine dehydrogenase; Provisional; Region: PRK06349 698964002697 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 698964002698 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 698964002699 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 698964002700 homoserine kinase; Provisional; Region: PRK01212 698964002701 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620 698964002702 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698964002703 acyl-activating enzyme (AAE) consensus motif; other site 698964002704 AMP binding site [chemical binding]; other site 698964002705 active site 698964002706 CoA binding site [chemical binding]; other site 698964002707 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 698964002708 transcription termination factor Rho; Provisional; Region: PRK12608 698964002709 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698964002710 RNA binding site [nucleotide binding]; other site 698964002711 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 698964002712 multimer interface [polypeptide binding]; other site 698964002713 Walker A motif; other site 698964002714 ATP binding site [chemical binding]; other site 698964002715 Walker B motif; other site 698964002716 peptide chain release factor 1; Validated; Region: prfA; PRK00591 698964002717 This domain is found in peptide chain release factors; Region: PCRF; smart00937 698964002718 RF-1 domain; Region: RF-1; pfam00472 698964002719 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 698964002720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698964002721 S-adenosylmethionine binding site [chemical binding]; other site 698964002722 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 698964002723 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 698964002724 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 698964002725 Mg++ binding site [ion binding]; other site 698964002726 putative catalytic motif [active] 698964002727 substrate binding site [chemical binding]; other site 698964002728 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 698964002729 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 698964002730 F0F1 ATP synthase subunit C; Validated; Region: PRK07874 698964002731 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 698964002732 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 698964002733 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 698964002734 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 698964002735 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 698964002736 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 698964002737 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 698964002738 beta subunit interaction interface [polypeptide binding]; other site 698964002739 Walker A motif; other site 698964002740 ATP binding site [chemical binding]; other site 698964002741 Walker B motif; other site 698964002742 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698964002743 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 698964002744 core domain interface [polypeptide binding]; other site 698964002745 delta subunit interface [polypeptide binding]; other site 698964002746 epsilon subunit interface [polypeptide binding]; other site 698964002747 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 698964002748 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 698964002749 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 698964002750 alpha subunit interaction interface [polypeptide binding]; other site 698964002751 Walker A motif; other site 698964002752 ATP binding site [chemical binding]; other site 698964002753 Walker B motif; other site 698964002754 inhibitor binding site; inhibition site 698964002755 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698964002756 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 698964002757 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 698964002758 gamma subunit interface [polypeptide binding]; other site 698964002759 epsilon subunit interface [polypeptide binding]; other site 698964002760 LBP interface [polypeptide binding]; other site 698964002761 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 698964002762 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 698964002763 hypothetical protein; Provisional; Region: PRK03298 698964002764 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 698964002765 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698964002766 dimer interface [polypeptide binding]; other site 698964002767 substrate binding site [chemical binding]; other site 698964002768 metal binding site [ion binding]; metal-binding site 698964002769 Domain of unknown function DUF77; Region: DUF77; pfam01910 698964002770 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698964002771 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698964002772 Walker A/P-loop; other site 698964002773 ATP binding site [chemical binding]; other site 698964002774 Q-loop/lid; other site 698964002775 ABC transporter signature motif; other site 698964002776 Walker B; other site 698964002777 D-loop; other site 698964002778 H-loop/switch region; other site 698964002779 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698964002780 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698964002781 ABC-ATPase subunit interface; other site 698964002782 dimer interface [polypeptide binding]; other site 698964002783 putative PBP binding regions; other site 698964002784 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698964002785 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698964002786 ABC-ATPase subunit interface; other site 698964002787 dimer interface [polypeptide binding]; other site 698964002788 putative PBP binding regions; other site 698964002789 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 698964002790 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698964002791 siderophore binding site; other site 698964002792 TIGR02611 family protein; Region: TIGR02611 698964002793 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 698964002794 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 698964002795 glycogen branching enzyme; Provisional; Region: PRK05402 698964002796 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 698964002797 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 698964002798 active site 698964002799 catalytic site [active] 698964002800 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 698964002801 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 698964002802 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 698964002803 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698964002804 active site 698964002805 homodimer interface [polypeptide binding]; other site 698964002806 catalytic site [active] 698964002807 acceptor binding site [chemical binding]; other site 698964002808 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698964002809 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698964002810 Walker A/P-loop; other site 698964002811 ATP binding site [chemical binding]; other site 698964002812 Q-loop/lid; other site 698964002813 ABC transporter signature motif; other site 698964002814 Walker B; other site 698964002815 D-loop; other site 698964002816 H-loop/switch region; other site 698964002817 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 698964002818 Ligand binding site [chemical binding]; other site 698964002819 Electron transfer flavoprotein domain; Region: ETF; pfam01012 698964002820 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 698964002821 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 698964002822 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 698964002823 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 698964002824 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 698964002825 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698964002826 catalytic residue [active] 698964002827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698964002828 S-adenosylmethionine binding site [chemical binding]; other site 698964002829 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 698964002830 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 698964002831 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 698964002832 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 698964002833 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698964002834 active site 698964002835 catalytic site [active] 698964002836 substrate binding site [chemical binding]; other site 698964002837 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 698964002838 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 698964002839 nucleotide binding pocket [chemical binding]; other site 698964002840 K-X-D-G motif; other site 698964002841 catalytic site [active] 698964002842 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 698964002843 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 698964002844 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 698964002845 Dimer interface [polypeptide binding]; other site 698964002846 BRCT sequence motif; other site 698964002847 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 698964002848 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 698964002849 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 698964002850 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 698964002851 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 698964002852 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698964002853 Coenzyme A binding pocket [chemical binding]; other site 698964002854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698964002855 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698964002856 putative substrate translocation pore; other site 698964002857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698964002858 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698964002859 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698964002860 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698964002861 ABC-ATPase subunit interface; other site 698964002862 dimer interface [polypeptide binding]; other site 698964002863 putative PBP binding regions; other site 698964002864 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698964002865 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698964002866 Walker A/P-loop; other site 698964002867 ATP binding site [chemical binding]; other site 698964002868 Q-loop/lid; other site 698964002869 ABC transporter signature motif; other site 698964002870 Walker B; other site 698964002871 D-loop; other site 698964002872 H-loop/switch region; other site 698964002873 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 698964002874 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 698964002875 putative ligand binding residues [chemical binding]; other site 698964002876 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 698964002877 phosphofructokinase; Region: PFK_mixed; TIGR02483 698964002878 active site 698964002879 ADP/pyrophosphate binding site [chemical binding]; other site 698964002880 dimerization interface [polypeptide binding]; other site 698964002881 allosteric effector site; other site 698964002882 fructose-1,6-bisphosphate binding site; other site 698964002883 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 698964002884 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 698964002885 GatB domain; Region: GatB_Yqey; smart00845 698964002886 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698964002887 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698964002888 active site 698964002889 catalytic tetrad [active] 698964002890 Lysine efflux permease [General function prediction only]; Region: COG1279 698964002891 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 698964002892 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698964002893 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698964002894 dimerization interface [polypeptide binding]; other site 698964002895 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 698964002896 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 698964002897 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 698964002898 putative dimer interface [polypeptide binding]; other site 698964002899 N-terminal domain interface [polypeptide binding]; other site 698964002900 putative substrate binding pocket (H-site) [chemical binding]; other site 698964002901 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 698964002902 Predicted membrane protein [Function unknown]; Region: COG2259 698964002903 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 698964002904 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 698964002905 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 698964002906 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 698964002907 PYR/PP interface [polypeptide binding]; other site 698964002908 dimer interface [polypeptide binding]; other site 698964002909 TPP binding site [chemical binding]; other site 698964002910 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698964002911 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 698964002912 TPP-binding site [chemical binding]; other site 698964002913 dimer interface [polypeptide binding]; other site 698964002914 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 698964002915 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 698964002916 putative valine binding site [chemical binding]; other site 698964002917 dimer interface [polypeptide binding]; other site 698964002918 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 698964002919 ketol-acid reductoisomerase; Provisional; Region: PRK05479 698964002920 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 698964002921 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 698964002922 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 698964002923 Uncharacterized conserved protein [Function unknown]; Region: COG1479 698964002924 Protein of unknown function DUF262; Region: DUF262; pfam03235 698964002925 Uncharacterized conserved protein [Function unknown]; Region: COG3472 698964002926 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 698964002927 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 698964002928 ligand binding site [chemical binding]; other site 698964002929 NAD binding site [chemical binding]; other site 698964002930 dimerization interface [polypeptide binding]; other site 698964002931 catalytic site [active] 698964002932 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 698964002933 putative L-serine binding site [chemical binding]; other site 698964002934 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 698964002935 tartrate dehydrogenase; Region: TTC; TIGR02089 698964002936 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698964002937 ligand binding site [chemical binding]; other site 698964002938 flexible hinge region; other site 698964002939 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 698964002940 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698964002941 metal binding triad; other site 698964002942 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 698964002943 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 698964002944 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 698964002945 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 698964002946 catalytic site [active] 698964002947 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 698964002948 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 698964002949 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 698964002950 S-adenosylmethionine binding site [chemical binding]; other site 698964002951 Methyltransferase domain; Region: Methyltransf_18; pfam12847 698964002952 isochorismate synthase DhbC; Validated; Region: PRK06923 698964002953 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698964002954 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 698964002955 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 698964002956 active site 698964002957 HIGH motif; other site 698964002958 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 698964002959 active site 698964002960 KMSKS motif; other site 698964002961 Predicted esterase [General function prediction only]; Region: COG0400 698964002962 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 698964002963 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 698964002964 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 698964002965 PhnA protein; Region: PhnA; pfam03831 698964002966 biotin synthase; Region: bioB; TIGR00433 698964002967 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698964002968 FeS/SAM binding site; other site 698964002969 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 698964002970 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 698964002971 HD domain; Region: HD_4; pfam13328 698964002972 Transcriptional regulator [Transcription]; Region: IclR; COG1414 698964002973 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698964002974 putative DNA binding site [nucleotide binding]; other site 698964002975 putative Zn2+ binding site [ion binding]; other site 698964002976 Bacterial transcriptional regulator; Region: IclR; pfam01614 698964002977 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 698964002978 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 698964002979 substrate binding site [chemical binding]; other site 698964002980 ligand binding site [chemical binding]; other site 698964002981 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 698964002982 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 698964002983 substrate binding site [chemical binding]; other site 698964002984 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 698964002985 active site 698964002986 Ap6A binding site [chemical binding]; other site 698964002987 nudix motif; other site 698964002988 metal binding site [ion binding]; metal-binding site 698964002989 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698964002990 catalytic core [active] 698964002991 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 698964002992 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 698964002993 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 698964002994 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 698964002995 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 698964002996 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698964002997 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 698964002998 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 698964002999 thiamine monophosphate kinase; Provisional; Region: PRK05731 698964003000 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 698964003001 ATP binding site [chemical binding]; other site 698964003002 dimerization interface [polypeptide binding]; other site 698964003003 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 698964003004 ligand binding site [chemical binding]; other site 698964003005 active site 698964003006 UGI interface [polypeptide binding]; other site 698964003007 catalytic site [active] 698964003008 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 698964003009 DAK2 domain; Region: Dak2; pfam02734 698964003010 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 698964003011 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 698964003012 generic binding surface II; other site 698964003013 ssDNA binding site; other site 698964003014 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698964003015 ATP binding site [chemical binding]; other site 698964003016 putative Mg++ binding site [ion binding]; other site 698964003017 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698964003018 nucleotide binding region [chemical binding]; other site 698964003019 ATP-binding site [chemical binding]; other site 698964003020 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698964003021 carboxyltransferase (CT) interaction site; other site 698964003022 biotinylation site [posttranslational modification]; other site 698964003023 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 698964003024 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698964003025 S-adenosylmethionine binding site [chemical binding]; other site 698964003026 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 698964003027 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 698964003028 active site 698964003029 (T/H)XGH motif; other site 698964003030 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 698964003031 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698964003032 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698964003033 Walker A/P-loop; other site 698964003034 ATP binding site [chemical binding]; other site 698964003035 Q-loop/lid; other site 698964003036 ABC transporter signature motif; other site 698964003037 Walker B; other site 698964003038 D-loop; other site 698964003039 H-loop/switch region; other site 698964003040 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698964003041 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698964003042 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698964003043 dimer interface [polypeptide binding]; other site 698964003044 conserved gate region; other site 698964003045 putative PBP binding loops; other site 698964003046 ABC-ATPase subunit interface; other site 698964003047 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698964003048 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698964003049 substrate binding pocket [chemical binding]; other site 698964003050 membrane-bound complex binding site; other site 698964003051 hinge residues; other site 698964003052 Domain of unknown function (DUF368); Region: DUF368; pfam04018 698964003053 DNA polymerase I; Provisional; Region: PRK05755 698964003054 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 698964003055 active site 698964003056 metal binding site 1 [ion binding]; metal-binding site 698964003057 putative 5' ssDNA interaction site; other site 698964003058 metal binding site 3; metal-binding site 698964003059 metal binding site 2 [ion binding]; metal-binding site 698964003060 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 698964003061 putative DNA binding site [nucleotide binding]; other site 698964003062 putative metal binding site [ion binding]; other site 698964003063 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 698964003064 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 698964003065 active site 698964003066 DNA binding site [nucleotide binding] 698964003067 catalytic site [active] 698964003068 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698964003069 S-adenosylmethionine binding site [chemical binding]; other site 698964003070 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 698964003071 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 698964003072 RNA binding site [nucleotide binding]; other site 698964003073 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 698964003074 RNA binding site [nucleotide binding]; other site 698964003075 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698964003076 RNA binding site [nucleotide binding]; other site 698964003077 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 698964003078 RNA binding site [nucleotide binding]; other site 698964003079 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 698964003080 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 698964003081 transcriptional antiterminator BglG; Provisional; Region: PRK09772 698964003082 CAT RNA binding domain; Region: CAT_RBD; smart01061 698964003083 PRD domain; Region: PRD; pfam00874 698964003084 PRD domain; Region: PRD; pfam00874 698964003085 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 698964003086 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 698964003087 active site turn [active] 698964003088 phosphorylation site [posttranslational modification] 698964003089 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 698964003090 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 698964003091 HPr interaction site; other site 698964003092 glycerol kinase (GK) interaction site [polypeptide binding]; other site 698964003093 active site 698964003094 phosphorylation site [posttranslational modification] 698964003095 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 698964003096 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 698964003097 CoA-binding site [chemical binding]; other site 698964003098 ATP-binding [chemical binding]; other site 698964003099 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 698964003100 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698964003101 FeS/SAM binding site; other site 698964003102 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 698964003103 excinuclease ABC subunit B; Provisional; Region: PRK05298 698964003104 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698964003105 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698964003106 nucleotide binding region [chemical binding]; other site 698964003107 ATP-binding site [chemical binding]; other site 698964003108 Ultra-violet resistance protein B; Region: UvrB; pfam12344 698964003109 UvrB/uvrC motif; Region: UVR; pfam02151 698964003110 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698964003111 Ligand Binding Site [chemical binding]; other site 698964003112 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 698964003113 Part of AAA domain; Region: AAA_19; pfam13245 698964003114 PhoH-like protein; Region: PhoH; cl17668 698964003115 Family description; Region: UvrD_C_2; pfam13538 698964003116 Predicted membrane protein [Function unknown]; Region: COG2259 698964003117 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698964003118 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 698964003119 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698964003120 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698964003121 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 698964003122 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 698964003123 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 698964003124 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 698964003125 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 698964003126 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 698964003127 23S rRNA binding site [nucleotide binding]; other site 698964003128 L21 binding site [polypeptide binding]; other site 698964003129 L13 binding site [polypeptide binding]; other site 698964003130 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698964003131 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 698964003132 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698964003133 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 698964003134 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 698964003135 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 698964003136 dimer interface [polypeptide binding]; other site 698964003137 motif 1; other site 698964003138 active site 698964003139 motif 2; other site 698964003140 motif 3; other site 698964003141 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 698964003142 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 698964003143 putative tRNA-binding site [nucleotide binding]; other site 698964003144 B3/4 domain; Region: B3_4; pfam03483 698964003145 tRNA synthetase B5 domain; Region: B5; smart00874 698964003146 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 698964003147 dimer interface [polypeptide binding]; other site 698964003148 motif 1; other site 698964003149 motif 3; other site 698964003150 motif 2; other site 698964003151 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 698964003152 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 698964003153 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 698964003154 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 698964003155 heterotetramer interface [polypeptide binding]; other site 698964003156 active site pocket [active] 698964003157 cleavage site 698964003158 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 698964003159 feedback inhibition sensing region; other site 698964003160 homohexameric interface [polypeptide binding]; other site 698964003161 nucleotide binding site [chemical binding]; other site 698964003162 N-acetyl-L-glutamate binding site [chemical binding]; other site 698964003163 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 698964003164 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698964003165 inhibitor-cofactor binding pocket; inhibition site 698964003166 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698964003167 catalytic residue [active] 698964003168 ornithine carbamoyltransferase; Provisional; Region: PRK00779 698964003169 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 698964003170 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 698964003171 arginine repressor; Provisional; Region: PRK03341 698964003172 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 698964003173 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 698964003174 argininosuccinate synthase; Provisional; Region: PRK13820 698964003175 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 698964003176 ANP binding site [chemical binding]; other site 698964003177 Substrate Binding Site II [chemical binding]; other site 698964003178 Substrate Binding Site I [chemical binding]; other site 698964003179 argininosuccinate lyase; Provisional; Region: PRK00855 698964003180 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 698964003181 active sites [active] 698964003182 tetramer interface [polypeptide binding]; other site 698964003183 Uncharacterized conserved protein [Function unknown]; Region: COG2835 698964003184 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 698964003185 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 698964003186 active site 698964003187 HIGH motif; other site 698964003188 dimer interface [polypeptide binding]; other site 698964003189 KMSKS motif; other site 698964003190 transcription termination factor Rho; Provisional; Region: PRK12678 698964003191 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 698964003192 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698964003193 active site 698964003194 motif I; other site 698964003195 motif II; other site 698964003196 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698964003197 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 698964003198 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698964003199 RNA binding surface [nucleotide binding]; other site 698964003200 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698964003201 S-adenosylmethionine binding site [chemical binding]; other site 698964003202 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 698964003203 ATP-NAD kinase; Region: NAD_kinase; pfam01513 698964003204 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 698964003205 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 698964003206 Walker A/P-loop; other site 698964003207 ATP binding site [chemical binding]; other site 698964003208 Q-loop/lid; other site 698964003209 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 698964003210 ABC transporter signature motif; other site 698964003211 Walker B; other site 698964003212 D-loop; other site 698964003213 H-loop/switch region; other site 698964003214 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 698964003215 Thiamine pyrophosphokinase; Region: TPK; cl08415 698964003216 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 698964003217 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 698964003218 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 698964003219 dimer interface [polypeptide binding]; other site 698964003220 ADP-ribose binding site [chemical binding]; other site 698964003221 active site 698964003222 nudix motif; other site 698964003223 metal binding site [ion binding]; metal-binding site 698964003224 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 698964003225 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 698964003226 active site 698964003227 Int/Topo IB signature motif; other site 698964003228 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 698964003229 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698964003230 P-loop; other site 698964003231 Magnesium ion binding site [ion binding]; other site 698964003232 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698964003233 Magnesium ion binding site [ion binding]; other site 698964003234 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 698964003235 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 698964003236 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 698964003237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698964003238 POT family; Region: PTR2; cl17359 698964003239 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05630 698964003240 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698964003241 inhibitor-cofactor binding pocket; inhibition site 698964003242 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698964003243 catalytic residue [active] 698964003244 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 698964003245 AAA domain; Region: AAA_26; pfam13500 698964003246 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 698964003247 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 698964003248 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 698964003249 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698964003250 RNA binding surface [nucleotide binding]; other site 698964003251 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 698964003252 active site 698964003253 cytidylate kinase; Provisional; Region: cmk; PRK00023 698964003254 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 698964003255 CMP-binding site; other site 698964003256 The sites determining sugar specificity; other site 698964003257 GTP-binding protein Der; Reviewed; Region: PRK03003 698964003258 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 698964003259 G1 box; other site 698964003260 GTP/Mg2+ binding site [chemical binding]; other site 698964003261 Switch I region; other site 698964003262 G2 box; other site 698964003263 Switch II region; other site 698964003264 G3 box; other site 698964003265 G4 box; other site 698964003266 G5 box; other site 698964003267 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 698964003268 G1 box; other site 698964003269 GTP/Mg2+ binding site [chemical binding]; other site 698964003270 Switch I region; other site 698964003271 G2 box; other site 698964003272 G3 box; other site 698964003273 Switch II region; other site 698964003274 G4 box; other site 698964003275 G5 box; other site 698964003276 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 698964003277 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 698964003278 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698964003279 S-adenosylmethionine binding site [chemical binding]; other site 698964003280 Putative esterase; Region: Esterase; pfam00756 698964003281 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698964003282 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 698964003283 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698964003284 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 698964003285 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698964003286 nucleotide binding region [chemical binding]; other site 698964003287 ATP-binding site [chemical binding]; other site 698964003288 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 698964003289 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 698964003290 phosphopeptide binding site; other site 698964003291 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 698964003292 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698964003293 DNA binding residues [nucleotide binding] 698964003294 Bifunctional nuclease; Region: DNase-RNase; pfam02577 698964003295 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 698964003296 DNA binding residues [nucleotide binding] 698964003297 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698964003298 putative dimer interface [polypeptide binding]; other site 698964003299 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698964003300 metal ion-dependent adhesion site (MIDAS); other site 698964003301 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698964003302 Domain of unknown function DUF21; Region: DUF21; pfam01595 698964003303 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698964003304 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698964003305 Domain of unknown function DUF21; Region: DUF21; pfam01595 698964003306 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698964003307 Transporter associated domain; Region: CorC_HlyC; smart01091 698964003308 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 698964003309 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698964003310 ATP binding site [chemical binding]; other site 698964003311 Mg++ binding site [ion binding]; other site 698964003312 motif III; other site 698964003313 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698964003314 nucleotide binding region [chemical binding]; other site 698964003315 ATP-binding site [chemical binding]; other site 698964003316 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 698964003317 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 698964003318 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 698964003319 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 698964003320 CoenzymeA binding site [chemical binding]; other site 698964003321 subunit interaction site [polypeptide binding]; other site 698964003322 PHB binding site; other site 698964003323 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 698964003324 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 698964003325 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 698964003326 oligomer interface [polypeptide binding]; other site 698964003327 metal binding site [ion binding]; metal-binding site 698964003328 metal binding site [ion binding]; metal-binding site 698964003329 putative Cl binding site [ion binding]; other site 698964003330 basic sphincter; other site 698964003331 hydrophobic gate; other site 698964003332 periplasmic entrance; other site 698964003333 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698964003334 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698964003335 S-adenosylmethionine binding site [chemical binding]; other site 698964003336 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 698964003337 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698964003338 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698964003339 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 698964003340 potential frameshift: common BLAST hit: gi|337290692|ref|YP_004629713.1| putative RNA helicase 698964003341 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 698964003342 potential frameshift: common BLAST hit: gi|227833113|ref|YP_002834820.1| oxidoreductase 698964003343 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 698964003344 potential frameshift: common BLAST hit: gi|337290692|ref|YP_004629713.1| putative RNA helicase 698964003345 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 698964003346 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 698964003347 FAD binding domain; Region: FAD_binding_4; pfam01565 698964003348 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 698964003349 Sodium Bile acid symporter family; Region: SBF; pfam01758 698964003350 YceI-like domain; Region: YceI; pfam04264 698964003351 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 698964003352 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 698964003353 Ligand binding site; other site 698964003354 Putative Catalytic site; other site 698964003355 DXD motif; other site 698964003356 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 698964003357 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 698964003358 putative active site [active] 698964003359 catalytic triad [active] 698964003360 putative dimer interface [polypeptide binding]; other site 698964003361 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 698964003362 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 698964003363 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 698964003364 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 698964003365 precorrin-3B synthase; Region: CobG; TIGR02435 698964003366 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698964003367 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698964003368 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 698964003369 Precorrin-8X methylmutase; Region: CbiC; pfam02570 698964003370 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 698964003371 active site 698964003372 SAM binding site [chemical binding]; other site 698964003373 homodimer interface [polypeptide binding]; other site 698964003374 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 698964003375 active site 698964003376 SAM binding site [chemical binding]; other site 698964003377 homodimer interface [polypeptide binding]; other site 698964003378 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 698964003379 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 698964003380 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 698964003381 active site 698964003382 SAM binding site [chemical binding]; other site 698964003383 homodimer interface [polypeptide binding]; other site 698964003384 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 698964003385 active site 698964003386 putative homodimer interface [polypeptide binding]; other site 698964003387 SAM binding site [chemical binding]; other site 698964003388 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 698964003389 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698964003390 S-adenosylmethionine binding site [chemical binding]; other site 698964003391 hypothetical protein; Provisional; Region: PRK05599 698964003392 short chain dehydrogenase; Provisional; Region: PRK08251 698964003393 NAD(P) binding site [chemical binding]; other site 698964003394 active site 698964003395 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698964003396 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698964003397 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 698964003398 active site 698964003399 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698964003400 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698964003401 ATP binding site [chemical binding]; other site 698964003402 putative Mg++ binding site [ion binding]; other site 698964003403 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698964003404 nucleotide binding region [chemical binding]; other site 698964003405 ATP-binding site [chemical binding]; other site 698964003406 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 698964003407 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 698964003408 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 698964003409 twin arginine translocase protein A; Provisional; Region: tatA; PRK00191 698964003410 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 698964003411 Predicted transcriptional regulator [Transcription]; Region: COG2378 698964003412 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 698964003413 WYL domain; Region: WYL; pfam13280 698964003414 WYL domain; Region: WYL; pfam13280 698964003415 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 698964003416 Pup-like protein; Region: Pup; pfam05639 698964003417 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 698964003418 proteasome ATPase; Region: pup_AAA; TIGR03689 698964003419 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698964003420 Walker A motif; other site 698964003421 ATP binding site [chemical binding]; other site 698964003422 Walker B motif; other site 698964003423 arginine finger; other site 698964003424 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 698964003425 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698964003426 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 698964003427 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 698964003428 active site 698964003429 metal binding site [ion binding]; metal-binding site 698964003430 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 698964003431 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 698964003432 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 698964003433 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 698964003434 Potassium binding sites [ion binding]; other site 698964003435 Cesium cation binding sites [ion binding]; other site 698964003436 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 698964003437 Aspartase; Region: Aspartase; cd01357 698964003438 active sites [active] 698964003439 tetramer interface [polypeptide binding]; other site 698964003440 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 698964003441 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 698964003442 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 698964003443 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 698964003444 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 698964003445 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 698964003446 homodimer interface [polypeptide binding]; other site 698964003447 putative metal binding site [ion binding]; other site 698964003448 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 698964003449 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698964003450 motif II; other site 698964003451 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 698964003452 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 698964003453 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 698964003454 substrate binding pocket [chemical binding]; other site 698964003455 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 698964003456 B12 binding site [chemical binding]; other site 698964003457 cobalt ligand [ion binding]; other site 698964003458 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 698964003459 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 698964003460 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698964003461 active site 698964003462 HIGH motif; other site 698964003463 nucleotide binding site [chemical binding]; other site 698964003464 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698964003465 active site 698964003466 KMSKS motif; other site 698964003467 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 698964003468 tRNA binding surface [nucleotide binding]; other site 698964003469 anticodon binding site; other site 698964003470 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 698964003471 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 698964003472 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 698964003473 quinone interaction residues [chemical binding]; other site 698964003474 active site 698964003475 catalytic residues [active] 698964003476 FMN binding site [chemical binding]; other site 698964003477 substrate binding site [chemical binding]; other site 698964003478 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 698964003479 substrate binding site [chemical binding]; other site 698964003480 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698964003481 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698964003482 HTH-like domain; Region: HTH_21; pfam13276 698964003483 Integrase core domain; Region: rve; pfam00665 698964003484 Integrase core domain; Region: rve_2; pfam13333 698964003485 potential frameshift: common BLAST hit: gi|256379310|ref|YP_003102970.1| oxidoreductase 698964003486 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698964003487 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698964003488 active site residue [active] 698964003489 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 698964003490 active site residue [active] 698964003491 membrane ATPase/protein kinase; Provisional; Region: PRK09435 698964003492 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 698964003493 Walker A; other site 698964003494 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 698964003495 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 698964003496 active site 698964003497 substrate binding site [chemical binding]; other site 698964003498 coenzyme B12 binding site [chemical binding]; other site 698964003499 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 698964003500 B12 binding site [chemical binding]; other site 698964003501 cobalt ligand [ion binding]; other site 698964003502 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 698964003503 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 698964003504 heterodimer interface [polypeptide binding]; other site 698964003505 substrate interaction site [chemical binding]; other site 698964003506 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 698964003507 Uncharacterized conserved protein [Function unknown]; Region: COG0398 698964003508 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 698964003509 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 698964003510 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 698964003511 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 698964003512 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 698964003513 ferrochelatase; Reviewed; Region: hemH; PRK00035 698964003514 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 698964003515 C-terminal domain interface [polypeptide binding]; other site 698964003516 active site 698964003517 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 698964003518 active site 698964003519 N-terminal domain interface [polypeptide binding]; other site 698964003520 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698964003521 NlpC/P60 family; Region: NLPC_P60; pfam00877 698964003522 aconitate hydratase; Validated; Region: PRK09277 698964003523 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 698964003524 substrate binding site [chemical binding]; other site 698964003525 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 698964003526 ligand binding site [chemical binding]; other site 698964003527 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 698964003528 substrate binding site [chemical binding]; other site 698964003529 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698964003530 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698964003531 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 698964003532 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 698964003533 catalytic triad [active] 698964003534 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 698964003535 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 698964003536 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698964003537 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698964003538 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698964003539 Walker A/P-loop; other site 698964003540 ATP binding site [chemical binding]; other site 698964003541 Q-loop/lid; other site 698964003542 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698964003543 ABC transporter signature motif; other site 698964003544 Walker B; other site 698964003545 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698964003546 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 698964003547 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 698964003548 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 698964003549 trimerization site [polypeptide binding]; other site 698964003550 active site 698964003551 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 698964003552 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 698964003553 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698964003554 catalytic residue [active] 698964003555 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 698964003556 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 698964003557 Walker A/P-loop; other site 698964003558 ATP binding site [chemical binding]; other site 698964003559 Q-loop/lid; other site 698964003560 ABC transporter signature motif; other site 698964003561 Walker B; other site 698964003562 D-loop; other site 698964003563 H-loop/switch region; other site 698964003564 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 698964003565 FeS assembly protein SufD; Region: sufD; TIGR01981 698964003566 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 698964003567 FeS assembly protein SufB; Region: sufB; TIGR01980 698964003568 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698964003569 Predicted transcriptional regulator [Transcription]; Region: COG2345 698964003570 putative DNA binding site [nucleotide binding]; other site 698964003571 putative Zn2+ binding site [ion binding]; other site 698964003572 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698964003573 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698964003574 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698964003575 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 698964003576 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698964003577 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698964003578 Walker A/P-loop; other site 698964003579 ATP binding site [chemical binding]; other site 698964003580 Q-loop/lid; other site 698964003581 ABC transporter signature motif; other site 698964003582 Walker B; other site 698964003583 D-loop; other site 698964003584 H-loop/switch region; other site 698964003585 ABC-2 type transporter; Region: ABC2_membrane; cl17235 698964003586 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 698964003587 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 698964003588 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 698964003589 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 698964003590 UbiA prenyltransferase family; Region: UbiA; pfam01040 698964003591 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 698964003592 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 698964003593 TPP-binding site [chemical binding]; other site 698964003594 dimer interface [polypeptide binding]; other site 698964003595 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 698964003596 PYR/PP interface [polypeptide binding]; other site 698964003597 dimer interface [polypeptide binding]; other site 698964003598 TPP binding site [chemical binding]; other site 698964003599 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698964003600 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 698964003601 putative active site [active] 698964003602 transaldolase; Provisional; Region: PRK03903 698964003603 catalytic residue [active] 698964003604 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 698964003605 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 698964003606 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 698964003607 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 698964003608 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 698964003609 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 698964003610 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 698964003611 putative active site [active] 698964003612 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 698964003613 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 698964003614 triosephosphate isomerase; Provisional; Region: PRK14567 698964003615 substrate binding site [chemical binding]; other site 698964003616 dimer interface [polypeptide binding]; other site 698964003617 catalytic triad [active] 698964003618 Phosphoglycerate kinase; Region: PGK; pfam00162 698964003619 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 698964003620 substrate binding site [chemical binding]; other site 698964003621 hinge regions; other site 698964003622 ADP binding site [chemical binding]; other site 698964003623 catalytic site [active] 698964003624 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 698964003625 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 698964003626 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 698964003627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 698964003628 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 698964003629 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 698964003630 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 698964003631 phosphate binding site [ion binding]; other site 698964003632 putative substrate binding pocket [chemical binding]; other site 698964003633 dimer interface [polypeptide binding]; other site 698964003634 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 698964003635 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 698964003636 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 698964003637 GIY-YIG motif/motif A; other site 698964003638 active site 698964003639 catalytic site [active] 698964003640 putative DNA binding site [nucleotide binding]; other site 698964003641 metal binding site [ion binding]; metal-binding site 698964003642 UvrB/uvrC motif; Region: UVR; pfam02151 698964003643 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 698964003644 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 698964003645 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 698964003646 homopentamer interface [polypeptide binding]; other site 698964003647 active site 698964003648 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 698964003649 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 698964003650 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 698964003651 dimerization interface [polypeptide binding]; other site 698964003652 active site 698964003653 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 698964003654 Lumazine binding domain; Region: Lum_binding; pfam00677 698964003655 Lumazine binding domain; Region: Lum_binding; pfam00677 698964003656 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 698964003657 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 698964003658 catalytic motif [active] 698964003659 Zn binding site [ion binding]; other site 698964003660 RibD C-terminal domain; Region: RibD_C; pfam01872 698964003661 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 698964003662 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 698964003663 substrate binding site [chemical binding]; other site 698964003664 hexamer interface [polypeptide binding]; other site 698964003665 metal binding site [ion binding]; metal-binding site 698964003666 16S rRNA methyltransferase B; Provisional; Region: PRK14902 698964003667 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 698964003668 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698964003669 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 698964003670 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 698964003671 putative active site [active] 698964003672 substrate binding site [chemical binding]; other site 698964003673 putative cosubstrate binding site; other site 698964003674 catalytic site [active] 698964003675 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 698964003676 substrate binding site [chemical binding]; other site 698964003677 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 698964003678 active site 698964003679 catalytic residues [active] 698964003680 metal binding site [ion binding]; metal-binding site 698964003681 primosome assembly protein PriA; Provisional; Region: PRK14873 698964003682 S-adenosylmethionine synthetase; Validated; Region: PRK05250 698964003683 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 698964003684 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 698964003685 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 698964003686 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 698964003687 Flavoprotein; Region: Flavoprotein; pfam02441 698964003688 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 698964003689 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 698964003690 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 698964003691 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 698964003692 catalytic site [active] 698964003693 G-X2-G-X-G-K; other site 698964003694 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 698964003695 active site 698964003696 dimer interface [polypeptide binding]; other site 698964003697 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 698964003698 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698964003699 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698964003700 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 698964003701 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698964003702 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698964003703 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 698964003704 IMP binding site; other site 698964003705 dimer interface [polypeptide binding]; other site 698964003706 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 698964003707 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 698964003708 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 698964003709 catalytic site [active] 698964003710 subunit interface [polypeptide binding]; other site 698964003711 dihydroorotase; Validated; Region: pyrC; PRK09357 698964003712 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698964003713 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 698964003714 active site 698964003715 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 698964003716 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 698964003717 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 698964003718 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 698964003719 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698964003720 active site 698964003721 hydrophobic ligand binding site; other site 698964003722 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 698964003723 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698964003724 TIGR01777 family protein; Region: yfcH 698964003725 NAD(P) binding site [chemical binding]; other site 698964003726 active site 698964003727 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 698964003728 elongation factor P; Validated; Region: PRK00529 698964003729 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 698964003730 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 698964003731 RNA binding site [nucleotide binding]; other site 698964003732 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 698964003733 RNA binding site [nucleotide binding]; other site 698964003734 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698964003735 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698964003736 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 698964003737 active site 698964003738 Dehydroquinase class II; Region: DHquinase_II; pfam01220 698964003739 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 698964003740 trimer interface [polypeptide binding]; other site 698964003741 active site 698964003742 dimer interface [polypeptide binding]; other site 698964003743 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 698964003744 active site 698964003745 dimer interface [polypeptide binding]; other site 698964003746 metal binding site [ion binding]; metal-binding site 698964003747 shikimate kinase; Reviewed; Region: aroK; PRK00131 698964003748 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 698964003749 ADP binding site [chemical binding]; other site 698964003750 magnesium binding site [ion binding]; other site 698964003751 putative shikimate binding site; other site 698964003752 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 698964003753 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 698964003754 Tetramer interface [polypeptide binding]; other site 698964003755 active site 698964003756 FMN-binding site [chemical binding]; other site 698964003757 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 698964003758 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 698964003759 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 698964003760 shikimate binding site; other site 698964003761 NAD(P) binding site [chemical binding]; other site 698964003762 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 698964003763 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 698964003764 dimerization interface [polypeptide binding]; other site 698964003765 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 698964003766 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 698964003767 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 698964003768 motif 1; other site 698964003769 active site 698964003770 motif 2; other site 698964003771 motif 3; other site 698964003772 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 698964003773 DHHA1 domain; Region: DHHA1; pfam02272 698964003774 recombination factor protein RarA; Reviewed; Region: PRK13342 698964003775 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698964003776 Walker A motif; other site 698964003777 ATP binding site [chemical binding]; other site 698964003778 Walker B motif; other site 698964003779 arginine finger; other site 698964003780 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 698964003781 Phosphotransferase enzyme family; Region: APH; pfam01636 698964003782 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 698964003783 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 698964003784 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 698964003785 dimer interface [polypeptide binding]; other site 698964003786 anticodon binding site; other site 698964003787 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 698964003788 homodimer interface [polypeptide binding]; other site 698964003789 motif 1; other site 698964003790 active site 698964003791 motif 2; other site 698964003792 GAD domain; Region: GAD; pfam02938 698964003793 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698964003794 active site 698964003795 motif 3; other site 698964003796 Predicted metalloprotease [General function prediction only]; Region: COG2321 698964003797 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 698964003798 potential frameshift: common BLAST hit: gi|62390520|ref|YP_225922.1| SNF2 family DNA/RNA helicase 698964003799 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698964003800 ATP binding site [chemical binding]; other site 698964003801 putative Mg++ binding site [ion binding]; other site 698964003802 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698964003803 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 698964003804 nucleotide binding region [chemical binding]; other site 698964003805 ATP-binding site [chemical binding]; other site 698964003806 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 698964003807 Predicted membrane protein [Function unknown]; Region: COG1511 698964003808 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 698964003809 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698964003810 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698964003811 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698964003812 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 698964003813 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698964003814 Q-loop/lid; other site 698964003815 ABC transporter signature motif; other site 698964003816 Walker B; other site 698964003817 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698964003818 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698964003819 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 698964003820 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 698964003821 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 698964003822 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 698964003823 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 698964003824 dimer interface [polypeptide binding]; other site 698964003825 motif 1; other site 698964003826 active site 698964003827 motif 2; other site 698964003828 motif 3; other site 698964003829 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 698964003830 anticodon binding site; other site 698964003831 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698964003832 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 698964003833 dimer interface [polypeptide binding]; other site 698964003834 catalytic triad [active] 698964003835 peroxidatic and resolving cysteines [active] 698964003836 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 698964003837 active site 698964003838 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 698964003839 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698964003840 Zn2+ binding site [ion binding]; other site 698964003841 Mg2+ binding site [ion binding]; other site 698964003842 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 698964003843 synthetase active site [active] 698964003844 NTP binding site [chemical binding]; other site 698964003845 metal binding site [ion binding]; metal-binding site 698964003846 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 698964003847 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 698964003848 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698964003849 active site 698964003850 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 698964003851 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698964003852 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 698964003853 Protein export membrane protein; Region: SecD_SecF; cl14618 698964003854 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 698964003855 Protein export membrane protein; Region: SecD_SecF; cl14618 698964003856 Preprotein translocase subunit; Region: YajC; pfam02699 698964003857 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 698964003858 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698964003859 Walker A motif; other site 698964003860 ATP binding site [chemical binding]; other site 698964003861 Walker B motif; other site 698964003862 arginine finger; other site 698964003863 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 698964003864 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 698964003865 RuvA N terminal domain; Region: RuvA_N; pfam01330 698964003866 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 698964003867 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 698964003868 active site 698964003869 putative DNA-binding cleft [nucleotide binding]; other site 698964003870 dimer interface [polypeptide binding]; other site 698964003871 hypothetical protein; Validated; Region: PRK00110 698964003872 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 698964003873 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 698964003874 active site 698964003875 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 698964003876 catalytic triad [active] 698964003877 dimer interface [polypeptide binding]; other site 698964003878 putative transposase OrfB; Reviewed; Region: PHA02517 698964003879 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698964003880 Helix-turn-helix domain; Region: HTH_38; pfam13936 698964003881 Integrase core domain; Region: rve; pfam00665 698964003882 Integrase core domain; Region: rve; pfam00665 698964003883 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698964003884 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698964003885 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698964003886 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698964003887 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698964003888 non-specific DNA binding site [nucleotide binding]; other site 698964003889 salt bridge; other site 698964003890 sequence-specific DNA binding site [nucleotide binding]; other site 698964003891 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 698964003892 Nitronate monooxygenase; Region: NMO; pfam03060 698964003893 FMN binding site [chemical binding]; other site 698964003894 substrate binding site [chemical binding]; other site 698964003895 putative catalytic residue [active] 698964003896 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 698964003897 Replicase family; Region: Replicase; pfam03090 698964003898 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 698964003899 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 698964003900 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 698964003901 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 698964003902 catalytic residues [active] 698964003903 catalytic nucleophile [active] 698964003904 Presynaptic Site I dimer interface [polypeptide binding]; other site 698964003905 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 698964003906 Synaptic Flat tetramer interface [polypeptide binding]; other site 698964003907 Synaptic Site I dimer interface [polypeptide binding]; other site 698964003908 DNA binding site [nucleotide binding] 698964003909 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698964003910 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698964003911 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698964003912 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698964003913 non-specific DNA binding site [nucleotide binding]; other site 698964003914 salt bridge; other site 698964003915 sequence-specific DNA binding site [nucleotide binding]; other site 698964003916 potential frameshift: common BLAST hit: gi|336326698|ref|YP_004606664.1| transposase for insertion sequence element 698964003917 MULE transposase domain; Region: MULE; pfam10551 698964003918 potential frameshift: common BLAST hit: gi|336326698|ref|YP_004606664.1| transposase for insertion sequence element 698964003919 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698964003920 6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322 698964003921 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 698964003922 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698964003923 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698964003924 catalytic residue [active] 698964003925 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698964003926 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698964003927 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 698964003928 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 698964003929 putative acyl-acceptor binding pocket; other site 698964003930 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 698964003931 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 698964003932 nucleotide binding site/active site [active] 698964003933 HIT family signature motif; other site 698964003934 catalytic residue [active] 698964003935 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 698964003936 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 698964003937 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 698964003938 active site 698964003939 dimer interface [polypeptide binding]; other site 698964003940 motif 1; other site 698964003941 motif 2; other site 698964003942 motif 3; other site 698964003943 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 698964003944 anticodon binding site; other site 698964003945 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 698964003946 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 698964003947 Protein of unknown function (DUF461); Region: DUF461; pfam04314 698964003948 CopC domain; Region: CopC; cl01012 698964003949 hypothetical protein; Provisional; Region: PRK14059 698964003950 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 698964003951 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 698964003952 SelR domain; Region: SelR; pfam01641 698964003953 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 698964003954 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 698964003955 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 698964003956 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 698964003957 catalytic site [active] 698964003958 putative active site [active] 698964003959 putative substrate binding site [chemical binding]; other site 698964003960 HRDC domain; Region: HRDC; pfam00570 698964003961 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 698964003962 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 698964003963 TPP-binding site; other site 698964003964 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 698964003965 PYR/PP interface [polypeptide binding]; other site 698964003966 dimer interface [polypeptide binding]; other site 698964003967 TPP binding site [chemical binding]; other site 698964003968 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698964003969 TRAM domain; Region: TRAM; cl01282 698964003970 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 698964003971 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 698964003972 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 698964003973 trimer interface [polypeptide binding]; other site 698964003974 active site 698964003975 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 698964003976 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 698964003977 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698964003978 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 698964003979 active site 698964003980 dimerization interface [polypeptide binding]; other site 698964003981 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698964003982 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698964003983 nucleotide binding site [chemical binding]; other site 698964003984 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 698964003985 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 698964003986 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698964003987 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 698964003988 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698964003989 DNA binding residues [nucleotide binding] 698964003990 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698964003991 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698964003992 ATP binding site [chemical binding]; other site 698964003993 putative Mg++ binding site [ion binding]; other site 698964003994 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 698964003995 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 698964003996 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 698964003997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698964003998 S-adenosylmethionine binding site [chemical binding]; other site 698964003999 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 698964004000 putative active site [active] 698964004001 dimerization interface [polypeptide binding]; other site 698964004002 putative tRNAtyr binding site [nucleotide binding]; other site 698964004003 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 698964004004 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 698964004005 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698964004006 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 698964004007 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698964004008 DNA binding residues [nucleotide binding] 698964004009 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 698964004010 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 698964004011 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 698964004012 FeoA domain; Region: FeoA; cl00838 698964004013 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 698964004014 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 698964004015 NAD binding site [chemical binding]; other site 698964004016 homodimer interface [polypeptide binding]; other site 698964004017 active site 698964004018 substrate binding site [chemical binding]; other site 698964004019 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 698964004020 potential frameshift: common BLAST hit: gi|337290937|ref|YP_004629958.1| proteasome assembly chaperone 698964004021 PAC2 family; Region: PAC2; pfam09754 698964004022 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698964004023 ATP binding site [chemical binding]; other site 698964004024 putative Mg++ binding site [ion binding]; other site 698964004025 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698964004026 nucleotide binding region [chemical binding]; other site 698964004027 ATP-binding site [chemical binding]; other site 698964004028 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 698964004029 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 698964004030 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 698964004031 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 698964004032 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 698964004033 dimer interface [polypeptide binding]; other site 698964004034 decamer (pentamer of dimers) interface [polypeptide binding]; other site 698964004035 catalytic triad [active] 698964004036 peroxidatic and resolving cysteines [active] 698964004037 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698964004038 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 698964004039 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 698964004040 dimerization interface [polypeptide binding]; other site 698964004041 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 698964004042 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698964004043 ATP binding site [chemical binding]; other site 698964004044 putative Mg++ binding site [ion binding]; other site 698964004045 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698964004046 nucleotide binding region [chemical binding]; other site 698964004047 ATP-binding site [chemical binding]; other site 698964004048 Helicase associated domain (HA2); Region: HA2; pfam04408 698964004049 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 698964004050 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 698964004051 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 698964004052 ATP cone domain; Region: ATP-cone; pfam03477 698964004053 LexA repressor; Validated; Region: PRK00215 698964004054 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 698964004055 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 698964004056 Catalytic site [active] 698964004057 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698964004058 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 698964004059 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698964004060 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 698964004061 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 698964004062 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 698964004063 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 698964004064 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698964004065 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698964004066 DNA-binding site [nucleotide binding]; DNA binding site 698964004067 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698964004068 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 698964004069 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 698964004070 putative substrate binding site [chemical binding]; other site 698964004071 putative ATP binding site [chemical binding]; other site 698964004072 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 698964004073 dimerization domain swap beta strand [polypeptide binding]; other site 698964004074 regulatory protein interface [polypeptide binding]; other site 698964004075 active site 698964004076 regulatory phosphorylation site [posttranslational modification]; other site 698964004077 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 698964004078 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 698964004079 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 698964004080 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698964004081 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 698964004082 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 698964004083 GTPases [General function prediction only]; Region: HflX; COG2262 698964004084 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 698964004085 HflX GTPase family; Region: HflX; cd01878 698964004086 G1 box; other site 698964004087 GTP/Mg2+ binding site [chemical binding]; other site 698964004088 Switch I region; other site 698964004089 G2 box; other site 698964004090 G3 box; other site 698964004091 Switch II region; other site 698964004092 G4 box; other site 698964004093 G5 box; other site 698964004094 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 698964004095 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 698964004096 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 698964004097 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 698964004098 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 698964004099 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 698964004100 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 698964004101 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 698964004102 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698964004103 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 698964004104 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 698964004105 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698964004106 FeS/SAM binding site; other site 698964004107 recombination regulator RecX; Reviewed; Region: recX; PRK00117 698964004108 recombinase A; Provisional; Region: recA; PRK09354 698964004109 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 698964004110 hexamer interface [polypeptide binding]; other site 698964004111 Walker A motif; other site 698964004112 ATP binding site [chemical binding]; other site 698964004113 Walker B motif; other site 698964004114 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 698964004115 BioY family; Region: BioY; pfam02632 698964004116 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698964004117 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698964004118 Walker A/P-loop; other site 698964004119 ATP binding site [chemical binding]; other site 698964004120 Q-loop/lid; other site 698964004121 ABC transporter signature motif; other site 698964004122 Walker B; other site 698964004123 D-loop; other site 698964004124 H-loop/switch region; other site 698964004125 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 698964004126 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 698964004127 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698964004128 sequence-specific DNA binding site [nucleotide binding]; other site 698964004129 salt bridge; other site 698964004130 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698964004131 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698964004132 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698964004133 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698964004134 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698964004135 non-specific DNA binding site [nucleotide binding]; other site 698964004136 salt bridge; other site 698964004137 sequence-specific DNA binding site [nucleotide binding]; other site 698964004138 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 698964004139 YCII-related domain; Region: YCII; cl00999 698964004140 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 698964004141 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 698964004142 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698964004143 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 698964004144 TIGR03085 family protein; Region: TIGR03085 698964004145 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 698964004146 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 698964004147 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 698964004148 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 698964004149 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698964004150 dimer interface [polypeptide binding]; other site 698964004151 active site 698964004152 catalytic residue [active] 698964004153 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 698964004154 dihydrodipicolinate reductase; Provisional; Region: PRK00048 698964004155 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 698964004156 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 698964004157 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 698964004158 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 698964004159 oligomer interface [polypeptide binding]; other site 698964004160 RNA binding site [nucleotide binding]; other site 698964004161 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 698964004162 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 698964004163 RNase E interface [polypeptide binding]; other site 698964004164 trimer interface [polypeptide binding]; other site 698964004165 active site 698964004166 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 698964004167 putative nucleic acid binding region [nucleotide binding]; other site 698964004168 G-X-X-G motif; other site 698964004169 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 698964004170 RNA binding site [nucleotide binding]; other site 698964004171 domain interface; other site 698964004172 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 698964004173 16S/18S rRNA binding site [nucleotide binding]; other site 698964004174 S13e-L30e interaction site [polypeptide binding]; other site 698964004175 25S rRNA binding site [nucleotide binding]; other site 698964004176 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 698964004177 active site 698964004178 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 698964004179 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 698964004180 active site 698964004181 Riboflavin kinase; Region: Flavokinase; smart00904 698964004182 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 698964004183 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 698964004184 RNA binding site [nucleotide binding]; other site 698964004185 active site 698964004186 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 698964004187 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 698964004188 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 698964004189 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698964004190 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 698964004191 active site 698964004192 metal binding site [ion binding]; metal-binding site 698964004193 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 698964004194 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 698964004195 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 698964004196 DHH family; Region: DHH; pfam01368 698964004197 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 698964004198 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698964004199 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698964004200 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 698964004201 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 698964004202 G1 box; other site 698964004203 putative GEF interaction site [polypeptide binding]; other site 698964004204 GTP/Mg2+ binding site [chemical binding]; other site 698964004205 Switch I region; other site 698964004206 G2 box; other site 698964004207 G3 box; other site 698964004208 Switch II region; other site 698964004209 G4 box; other site 698964004210 G5 box; other site 698964004211 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 698964004212 Translation-initiation factor 2; Region: IF-2; pfam11987 698964004213 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 698964004214 Protein of unknown function (DUF448); Region: DUF448; pfam04296 698964004215 putative RNA binding cleft [nucleotide binding]; other site 698964004216 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 698964004217 NusA N-terminal domain; Region: NusA_N; pfam08529 698964004218 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 698964004219 RNA binding site [nucleotide binding]; other site 698964004220 homodimer interface [polypeptide binding]; other site 698964004221 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 698964004222 G-X-X-G motif; other site 698964004223 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 698964004224 G-X-X-G motif; other site 698964004225 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 698964004226 Sm and related proteins; Region: Sm_like; cl00259 698964004227 prolyl-tRNA synthetase; Provisional; Region: PRK09194 698964004228 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 698964004229 dimer interface [polypeptide binding]; other site 698964004230 motif 1; other site 698964004231 active site 698964004232 motif 2; other site 698964004233 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 698964004234 putative deacylase active site [active] 698964004235 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698964004236 active site 698964004237 motif 3; other site 698964004238 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 698964004239 anticodon binding site; other site 698964004240 hypothetical protein; Validated; Region: PRK02101 698964004241 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 698964004242 active site 698964004243 SAM binding site [chemical binding]; other site 698964004244 homodimer interface [polypeptide binding]; other site 698964004245 Uncharacterized conserved protein [Function unknown]; Region: COG0397 698964004246 hypothetical protein; Validated; Region: PRK00029 698964004247 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 698964004248 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 698964004249 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 698964004250 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 698964004251 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 698964004252 catalytic triad [active] 698964004253 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 698964004254 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 698964004255 Walker A motif; other site 698964004256 homodimer interface [polypeptide binding]; other site 698964004257 ATP binding site [chemical binding]; other site 698964004258 hydroxycobalamin binding site [chemical binding]; other site 698964004259 Walker B motif; other site 698964004260 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 698964004261 metal ion-dependent adhesion site (MIDAS); other site 698964004262 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 698964004263 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698964004264 Walker A motif; other site 698964004265 ATP binding site [chemical binding]; other site 698964004266 Walker B motif; other site 698964004267 arginine finger; other site 698964004268 malate:quinone oxidoreductase; Validated; Region: PRK05257 698964004269 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 698964004270 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 698964004271 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698964004272 mycothione reductase; Region: mycothione_red; TIGR03452 698964004273 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698964004274 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698964004275 cobyric acid synthase; Provisional; Region: PRK00784 698964004276 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 698964004277 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698964004278 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 698964004279 catalytic triad [active] 698964004280 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 698964004281 active site 698964004282 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 698964004283 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 698964004284 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 698964004285 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 698964004286 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 698964004287 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 698964004288 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 698964004289 active site 698964004290 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 698964004291 protein binding site [polypeptide binding]; other site 698964004292 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 698964004293 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 698964004294 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 698964004295 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 698964004296 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 698964004297 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 698964004298 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698964004299 FeS/SAM binding site; other site 698964004300 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 698964004301 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 698964004302 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 698964004303 ribosome recycling factor; Reviewed; Region: frr; PRK00083 698964004304 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 698964004305 hinge region; other site 698964004306 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 698964004307 putative nucleotide binding site [chemical binding]; other site 698964004308 uridine monophosphate binding site [chemical binding]; other site 698964004309 homohexameric interface [polypeptide binding]; other site 698964004310 elongation factor Ts; Provisional; Region: tsf; PRK09377 698964004311 UBA/TS-N domain; Region: UBA; pfam00627 698964004312 Elongation factor TS; Region: EF_TS; pfam00889 698964004313 Elongation factor TS; Region: EF_TS; pfam00889 698964004314 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 698964004315 rRNA interaction site [nucleotide binding]; other site 698964004316 S8 interaction site; other site 698964004317 putative laminin-1 binding site; other site 698964004318 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 698964004319 Peptidase family M23; Region: Peptidase_M23; pfam01551 698964004320 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698964004321 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 698964004322 active site 698964004323 DNA binding site [nucleotide binding] 698964004324 Int/Topo IB signature motif; other site 698964004325 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 698964004326 DNA protecting protein DprA; Region: dprA; TIGR00732 698964004327 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 698964004328 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 698964004329 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698964004330 Walker A motif; other site 698964004331 ATP binding site [chemical binding]; other site 698964004332 Walker B motif; other site 698964004333 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 698964004334 hypothetical protein; Reviewed; Region: PRK12497 698964004335 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 698964004336 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 698964004337 RNA/DNA hybrid binding site [nucleotide binding]; other site 698964004338 active site 698964004339 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 698964004340 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 698964004341 Catalytic site [active] 698964004342 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 698964004343 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 698964004344 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 698964004345 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 698964004346 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 698964004347 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698964004348 RNA binding site [nucleotide binding]; other site 698964004349 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 698964004350 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 698964004351 RimM N-terminal domain; Region: RimM; pfam01782 698964004352 PRC-barrel domain; Region: PRC; pfam05239 698964004353 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 698964004354 signal recognition particle protein; Provisional; Region: PRK10867 698964004355 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 698964004356 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 698964004357 P loop; other site 698964004358 GTP binding site [chemical binding]; other site 698964004359 Signal peptide binding domain; Region: SRP_SPB; pfam02978 698964004360 PII uridylyl-transferase; Provisional; Region: glnD; PRK00227 698964004361 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698964004362 metal binding triad; other site 698964004363 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698964004364 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 698964004365 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 698964004366 Nitrogen regulatory protein P-II; Region: P-II; smart00938 698964004367 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 698964004368 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 698964004369 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 698964004370 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698964004371 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 698964004372 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 698964004373 Walker A/P-loop; other site 698964004374 ATP binding site [chemical binding]; other site 698964004375 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 698964004376 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 698964004377 ABC transporter signature motif; other site 698964004378 Walker B; other site 698964004379 D-loop; other site 698964004380 H-loop/switch region; other site 698964004381 Acylphosphatase; Region: Acylphosphatase; cl00551 698964004382 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 698964004383 amino acid carrier protein; Region: agcS; TIGR00835 698964004384 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 698964004385 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 698964004386 DNA binding site [nucleotide binding] 698964004387 catalytic residue [active] 698964004388 H2TH interface [polypeptide binding]; other site 698964004389 putative catalytic residues [active] 698964004390 turnover-facilitating residue; other site 698964004391 intercalation triad [nucleotide binding]; other site 698964004392 8OG recognition residue [nucleotide binding]; other site 698964004393 putative reading head residues; other site 698964004394 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698964004395 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 698964004396 ribonuclease III; Reviewed; Region: rnc; PRK00102 698964004397 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 698964004398 dimerization interface [polypeptide binding]; other site 698964004399 active site 698964004400 metal binding site [ion binding]; metal-binding site 698964004401 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 698964004402 dsRNA binding site [nucleotide binding]; other site 698964004403 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 698964004404 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 698964004405 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 698964004406 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 698964004407 active site 698964004408 catalytic site [active] 698964004409 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 698964004410 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 698964004411 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 698964004412 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 698964004413 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 698964004414 RNA binding site [nucleotide binding]; other site 698964004415 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 698964004416 potential frameshift: common BLAST hit: gi|227833048|ref|YP_002834755.1| transposase 698964004417 Winged helix-turn helix; Region: HTH_29; pfam13551 698964004418 Homeodomain-like domain; Region: HTH_23; cl17451 698964004419 glutamate dehydrogenase; Provisional; Region: PRK09414 698964004420 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 698964004421 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 698964004422 NAD(P) binding site [chemical binding]; other site 698964004423 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 698964004424 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 698964004425 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698964004426 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 698964004427 metal binding site [ion binding]; metal-binding site 698964004428 putative dimer interface [polypeptide binding]; other site 698964004429 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 698964004430 homodimer interface [polypeptide binding]; other site 698964004431 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 698964004432 active site pocket [active] 698964004433 pyruvate kinase; Provisional; Region: PRK06247 698964004434 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 698964004435 domain interfaces; other site 698964004436 active site 698964004437 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 698964004438 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 698964004439 active site 698964004440 ribulose/triose binding site [chemical binding]; other site 698964004441 phosphate binding site [ion binding]; other site 698964004442 substrate (anthranilate) binding pocket [chemical binding]; other site 698964004443 product (indole) binding pocket [chemical binding]; other site 698964004444 trp region conserved hypothetical membrane protein; Region: trp_oprn_chp; TIGR02234 698964004445 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 698964004446 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 698964004447 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 698964004448 substrate binding site [chemical binding]; other site 698964004449 glutamase interaction surface [polypeptide binding]; other site 698964004450 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 698964004451 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698964004452 active site 698964004453 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 698964004454 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 698964004455 catalytic residues [active] 698964004456 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 698964004457 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 698964004458 putative active site [active] 698964004459 oxyanion strand; other site 698964004460 catalytic triad [active] 698964004461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698964004462 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698964004463 putative substrate translocation pore; other site 698964004464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698964004465 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 698964004466 putative active site pocket [active] 698964004467 4-fold oligomerization interface [polypeptide binding]; other site 698964004468 metal binding residues [ion binding]; metal-binding site 698964004469 3-fold/trimer interface [polypeptide binding]; other site 698964004470 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 698964004471 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698964004472 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698964004473 homodimer interface [polypeptide binding]; other site 698964004474 catalytic residue [active] 698964004475 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 698964004476 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 698964004477 NAD binding site [chemical binding]; other site 698964004478 dimerization interface [polypeptide binding]; other site 698964004479 product binding site; other site 698964004480 substrate binding site [chemical binding]; other site 698964004481 zinc binding site [ion binding]; other site 698964004482 catalytic residues [active] 698964004483 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 698964004484 tetracycline repressor protein TetR; Provisional; Region: PRK13756 698964004485 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698964004486 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 698964004487 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 698964004488 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 698964004489 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 698964004490 active site 698964004491 catalytic site [active] 698964004492 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 698964004493 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 698964004494 active site 698964004495 catalytic site [active] 698964004496 substrate binding site [chemical binding]; other site 698964004497 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 698964004498 synthetase active site [active] 698964004499 NTP binding site [chemical binding]; other site 698964004500 metal binding site [ion binding]; metal-binding site 698964004501 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698964004502 RNA binding surface [nucleotide binding]; other site 698964004503 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 698964004504 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 698964004505 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 698964004506 threonine dehydratase; Validated; Region: PRK08639 698964004507 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 698964004508 tetramer interface [polypeptide binding]; other site 698964004509 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698964004510 catalytic residue [active] 698964004511 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 698964004512 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 698964004513 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 698964004514 active site 698964004515 PHP Thumb interface [polypeptide binding]; other site 698964004516 metal binding site [ion binding]; metal-binding site 698964004517 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 698964004518 generic binding surface II; other site 698964004519 generic binding surface I; other site 698964004520 Predicted permeases [General function prediction only]; Region: RarD; COG2962 698964004521 EamA-like transporter family; Region: EamA; cl17759 698964004522 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 698964004523 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698964004524 RNA binding surface [nucleotide binding]; other site 698964004525 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 698964004526 active site 698964004527 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 698964004528 lipoprotein signal peptidase; Provisional; Region: PRK14787 698964004529 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 698964004530 active site 698964004531 homotetramer interface [polypeptide binding]; other site 698964004532 homodimer interface [polypeptide binding]; other site 698964004533 DNA polymerase IV; Provisional; Region: PRK03348 698964004534 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 698964004535 active site 698964004536 DNA binding site [nucleotide binding] 698964004537 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 698964004538 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 698964004539 HIGH motif; other site 698964004540 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 698964004541 active site 698964004542 KMSKS motif; other site 698964004543 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 698964004544 tRNA binding surface [nucleotide binding]; other site 698964004545 anticodon binding site; other site 698964004546 DivIVA domain; Region: DivI1A_domain; TIGR03544 698964004547 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 698964004548 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 698964004549 YGGT family; Region: YGGT; cl00508 698964004550 Protein of unknown function (DUF552); Region: DUF552; cl00775 698964004551 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 698964004552 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 698964004553 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 698964004554 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 698964004555 nucleotide binding site [chemical binding]; other site 698964004556 SulA interaction site; other site 698964004557 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 698964004558 Cell division protein FtsQ; Region: FtsQ; pfam03799 698964004559 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 698964004560 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698964004561 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698964004562 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698964004563 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 698964004564 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 698964004565 active site 698964004566 homodimer interface [polypeptide binding]; other site 698964004567 cell division protein FtsW; Region: ftsW; TIGR02614 698964004568 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141 698964004569 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698964004570 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698964004571 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 698964004572 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 698964004573 Mg++ binding site [ion binding]; other site 698964004574 putative catalytic motif [active] 698964004575 putative substrate binding site [chemical binding]; other site 698964004576 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 698964004577 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698964004578 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698964004579 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698964004580 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 698964004581 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698964004582 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698964004583 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698964004584 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 698964004585 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 698964004586 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698964004587 MraW methylase family; Region: Methyltransf_5; cl17771 698964004588 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 698964004589 cell division protein MraZ; Reviewed; Region: PRK00326 698964004590 MraZ protein; Region: MraZ; pfam02381 698964004591 MraZ protein; Region: MraZ; pfam02381 698964004592 potential frameshift: common BLAST hit: gi|38234640|ref|NP_940407.1| transposase for insertion element 698964004593 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698964004594 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698964004595 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698964004596 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 698964004597 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 698964004598 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698964004599 Coenzyme A binding pocket [chemical binding]; other site 698964004600 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 698964004601 FAD binding site [chemical binding]; other site 698964004602 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 698964004603 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 698964004604 substrate binding pocket [chemical binding]; other site 698964004605 chain length determination region; other site 698964004606 substrate-Mg2+ binding site; other site 698964004607 catalytic residues [active] 698964004608 aspartate-rich region 1; other site 698964004609 active site lid residues [active] 698964004610 aspartate-rich region 2; other site 698964004611 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 698964004612 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698964004613 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698964004614 active site 698964004615 ATP binding site [chemical binding]; other site 698964004616 substrate binding site [chemical binding]; other site 698964004617 activation loop (A-loop); other site 698964004618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 698964004619 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698964004620 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698964004621 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698964004622 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698964004623 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 698964004624 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 698964004625 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 698964004626 putative acyl-acceptor binding pocket; other site 698964004627 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698964004628 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698964004629 nucleotide binding site [chemical binding]; other site 698964004630 Tesmin/TSO1-like CXC domain; Region: CXC; pfam03638 698964004631 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698964004632 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698964004633 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698964004634 NlpC/P60 family; Region: NLPC_P60; pfam00877 698964004635 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698964004636 NlpC/P60 family; Region: NLPC_P60; pfam00877 698964004637 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 698964004638 heme bH binding site [chemical binding]; other site 698964004639 intrachain domain interface; other site 698964004640 heme bL binding site [chemical binding]; other site 698964004641 interchain domain interface [polypeptide binding]; other site 698964004642 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 698964004643 Qo binding site; other site 698964004644 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 698964004645 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 698964004646 iron-sulfur cluster [ion binding]; other site 698964004647 [2Fe-2S] cluster binding site [ion binding]; other site 698964004648 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 698964004649 Cytochrome c; Region: Cytochrom_C; pfam00034 698964004650 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 698964004651 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 698964004652 Subunit I/III interface [polypeptide binding]; other site 698964004653 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 698964004654 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 698964004655 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 698964004656 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 698964004657 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 698964004658 active site 698964004659 dimer interface [polypeptide binding]; other site 698964004660 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 698964004661 Ligand Binding Site [chemical binding]; other site 698964004662 Molecular Tunnel; other site 698964004663 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 698964004664 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 698964004665 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 698964004666 homotrimer interface [polypeptide binding]; other site 698964004667 Walker A motif; other site 698964004668 GTP binding site [chemical binding]; other site 698964004669 Walker B motif; other site 698964004670 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 698964004671 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 698964004672 putative dimer interface [polypeptide binding]; other site 698964004673 active site pocket [active] 698964004674 putative cataytic base [active] 698964004675 cobalamin synthase; Reviewed; Region: cobS; PRK00235 698964004676 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 698964004677 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 698964004678 homodimer interface [polypeptide binding]; other site 698964004679 substrate-cofactor binding pocket; other site 698964004680 catalytic residue [active] 698964004681 multifunctional aminopeptidase A; Provisional; Region: PRK00913 698964004682 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 698964004683 interface (dimer of trimers) [polypeptide binding]; other site 698964004684 Substrate-binding/catalytic site; other site 698964004685 Zn-binding sites [ion binding]; other site 698964004686 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 698964004687 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698964004688 E3 interaction surface; other site 698964004689 lipoyl attachment site [posttranslational modification]; other site 698964004690 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698964004691 E3 interaction surface; other site 698964004692 lipoyl attachment site [posttranslational modification]; other site 698964004693 e3 binding domain; Region: E3_binding; pfam02817 698964004694 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 698964004695 lipoate-protein ligase B; Provisional; Region: PRK14345 698964004696 lipoyl synthase; Provisional; Region: PRK05481 698964004697 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698964004698 FeS/SAM binding site; other site 698964004699 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 698964004700 RDD family; Region: RDD; pfam06271 698964004701 glutamine synthetase, type I; Region: GlnA; TIGR00653 698964004702 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 698964004703 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698964004704 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698964004705 DNA binding site [nucleotide binding] 698964004706 Int/Topo IB signature motif; other site 698964004707 active site 698964004708 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698964004709 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698964004710 sequence-specific DNA binding site [nucleotide binding]; other site 698964004711 salt bridge; other site 698964004712 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 698964004713 DNA methylase; Region: N6_N4_Mtase; pfam01555 698964004714 DNA methylase; Region: N6_N4_Mtase; pfam01555 698964004715 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 698964004716 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698964004717 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509 698964004718 Predicted peptidase [General function prediction only]; Region: COG4099 698964004719 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 698964004720 Predicted permease [General function prediction only]; Region: COG2056 698964004721 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 698964004722 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698964004723 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698964004724 DNA-binding site [nucleotide binding]; DNA binding site 698964004725 FCD domain; Region: FCD; pfam07729 698964004726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698964004727 putative substrate translocation pore; other site 698964004728 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 698964004729 nudix motif; other site 698964004730 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 698964004731 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 698964004732 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698964004733 catalytic residue [active] 698964004734 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 698964004735 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 698964004736 heme binding pocket [chemical binding]; other site 698964004737 heme ligand [chemical binding]; other site 698964004738 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 698964004739 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698964004740 metal binding triad; other site 698964004741 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698964004742 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698964004743 metal binding triad; other site 698964004744 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698964004745 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 698964004746 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 698964004747 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698964004748 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 698964004749 putative active site; other site 698964004750 putative metal binding residues [ion binding]; other site 698964004751 signature motif; other site 698964004752 putative triphosphate binding site [ion binding]; other site 698964004753 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 698964004754 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 698964004755 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 698964004756 RNB domain; Region: RNB; pfam00773 698964004757 Predicted membrane protein [General function prediction only]; Region: COG4194 698964004758 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 698964004759 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 698964004760 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 698964004761 RNA/DNA hybrid binding site [nucleotide binding]; other site 698964004762 active site 698964004763 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698964004764 catalytic core [active] 698964004765 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 698964004766 Putative zinc ribbon domain; Region: DUF164; pfam02591 698964004767 Uncharacterized conserved protein [Function unknown]; Region: COG0327 698964004768 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 698964004769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 698964004770 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 698964004771 hypothetical protein; Provisional; Region: PRK07908 698964004772 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698964004773 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698964004774 homodimer interface [polypeptide binding]; other site 698964004775 catalytic residue [active] 698964004776 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 698964004777 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698964004778 motif II; other site 698964004779 Low molecular weight phosphatase family; Region: LMWPc; cd00115 698964004780 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 698964004781 active site 698964004782 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 698964004783 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 698964004784 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 698964004785 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 698964004786 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 698964004787 dimer interface [polypeptide binding]; other site 698964004788 TPP-binding site [chemical binding]; other site 698964004789 Electron transfer DM13; Region: DM13; pfam10517 698964004790 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698964004791 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 698964004792 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698964004793 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 698964004794 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698964004795 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 698964004796 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698964004797 active site 698964004798 motif I; other site 698964004799 motif II; other site 698964004800 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698964004801 motif II; other site 698964004802 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 698964004803 Beta-lactamase; Region: Beta-lactamase; pfam00144 698964004804 Predicted membrane protein [Function unknown]; Region: COG2860 698964004805 UPF0126 domain; Region: UPF0126; pfam03458 698964004806 UPF0126 domain; Region: UPF0126; pfam03458 698964004807 DNA primase; Validated; Region: dnaG; PRK05667 698964004808 CHC2 zinc finger; Region: zf-CHC2; pfam01807 698964004809 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 698964004810 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 698964004811 active site 698964004812 metal binding site [ion binding]; metal-binding site 698964004813 interdomain interaction site; other site 698964004814 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 698964004815 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 698964004816 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 698964004817 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 698964004818 glutaminase active site [active] 698964004819 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 698964004820 dimer interface [polypeptide binding]; other site 698964004821 active site 698964004822 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 698964004823 dimer interface [polypeptide binding]; other site 698964004824 active site 698964004825 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 698964004826 active site 698964004827 barstar interaction site; other site 698964004828 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 698964004829 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698964004830 Zn2+ binding site [ion binding]; other site 698964004831 Mg2+ binding site [ion binding]; other site 698964004832 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 698964004833 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 698964004834 putative active site [active] 698964004835 Repair protein; Region: Repair_PSII; pfam04536 698964004836 glycyl-tRNA synthetase; Provisional; Region: PRK04173 698964004837 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698964004838 motif 1; other site 698964004839 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 698964004840 active site 698964004841 motif 2; other site 698964004842 motif 3; other site 698964004843 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 698964004844 anticodon binding site; other site 698964004845 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698964004846 dimerization interface [polypeptide binding]; other site 698964004847 putative DNA binding site [nucleotide binding]; other site 698964004848 putative Zn2+ binding site [ion binding]; other site 698964004849 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 698964004850 metal binding site 2 [ion binding]; metal-binding site 698964004851 putative DNA binding helix; other site 698964004852 metal binding site 1 [ion binding]; metal-binding site 698964004853 dimer interface [polypeptide binding]; other site 698964004854 structural Zn2+ binding site [ion binding]; other site 698964004855 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 698964004856 diiron binding motif [ion binding]; other site 698964004857 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 698964004858 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 698964004859 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 698964004860 catalytic residue [active] 698964004861 putative FPP diphosphate binding site; other site 698964004862 putative FPP binding hydrophobic cleft; other site 698964004863 dimer interface [polypeptide binding]; other site 698964004864 putative IPP diphosphate binding site; other site 698964004865 Recombination protein O N terminal; Region: RecO_N; pfam11967 698964004866 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 698964004867 Recombination protein O C terminal; Region: RecO_C; pfam02565 698964004868 GTPase Era; Reviewed; Region: era; PRK00089 698964004869 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 698964004870 G1 box; other site 698964004871 GTP/Mg2+ binding site [chemical binding]; other site 698964004872 Switch I region; other site 698964004873 G2 box; other site 698964004874 Switch II region; other site 698964004875 G3 box; other site 698964004876 G4 box; other site 698964004877 G5 box; other site 698964004878 KH domain; Region: KH_2; pfam07650 698964004879 pyridoxamine kinase; Validated; Region: PRK05756 698964004880 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 698964004881 dimer interface [polypeptide binding]; other site 698964004882 pyridoxal binding site [chemical binding]; other site 698964004883 ATP binding site [chemical binding]; other site 698964004884 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698964004885 Domain of unknown function DUF21; Region: DUF21; pfam01595 698964004886 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698964004887 Transporter associated domain; Region: CorC_HlyC; smart01091 698964004888 metal-binding heat shock protein; Provisional; Region: PRK00016 698964004889 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 698964004890 PhoH-like protein; Region: PhoH; pfam02562 698964004891 RNA methyltransferase, RsmE family; Region: TIGR00046 698964004892 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 698964004893 chaperone protein DnaJ; Provisional; Region: PRK14278 698964004894 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698964004895 HSP70 interaction site [polypeptide binding]; other site 698964004896 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 698964004897 Zn binding sites [ion binding]; other site 698964004898 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 698964004899 dimer interface [polypeptide binding]; other site 698964004900 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 698964004901 coproporphyrinogen III oxidase; Validated; Region: PRK05628 698964004902 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698964004903 FeS/SAM binding site; other site 698964004904 HemN C-terminal domain; Region: HemN_C; pfam06969 698964004905 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698964004906 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 698964004907 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698964004908 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698964004909 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 698964004910 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 698964004911 acyl-activating enzyme (AAE) consensus motif; other site 698964004912 putative AMP binding site [chemical binding]; other site 698964004913 putative active site [active] 698964004914 putative CoA binding site [chemical binding]; other site 698964004915 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 698964004916 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 698964004917 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 698964004918 active site 698964004919 Zn binding site [ion binding]; other site 698964004920 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 698964004921 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 698964004922 substrate binding pocket [chemical binding]; other site 698964004923 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 698964004924 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 698964004925 active site 698964004926 metal binding site [ion binding]; metal-binding site 698964004927 nudix motif; other site 698964004928 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698964004929 active site 698964004930 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698964004931 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698964004932 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698964004933 Walker A/P-loop; other site 698964004934 ATP binding site [chemical binding]; other site 698964004935 Q-loop/lid; other site 698964004936 ABC transporter signature motif; other site 698964004937 Walker B; other site 698964004938 D-loop; other site 698964004939 H-loop/switch region; other site 698964004940 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 698964004941 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698964004942 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698964004943 homodimer interface [polypeptide binding]; other site 698964004944 catalytic residue [active] 698964004945 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698964004946 HTH-like domain; Region: HTH_21; pfam13276 698964004947 Integrase core domain; Region: rve; pfam00665 698964004948 Integrase core domain; Region: rve_2; pfam13333 698964004949 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 698964004950 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 698964004951 BCCT family transporter; Region: BCCT; pfam02028 698964004952 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698964004953 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 698964004954 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698964004955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698964004956 dimer interface [polypeptide binding]; other site 698964004957 conserved gate region; other site 698964004958 putative PBP binding loops; other site 698964004959 ABC-ATPase subunit interface; other site 698964004960 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698964004961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698964004962 dimer interface [polypeptide binding]; other site 698964004963 conserved gate region; other site 698964004964 putative PBP binding loops; other site 698964004965 ABC-ATPase subunit interface; other site 698964004966 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698964004967 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698964004968 Walker A/P-loop; other site 698964004969 ATP binding site [chemical binding]; other site 698964004970 Q-loop/lid; other site 698964004971 ABC transporter signature motif; other site 698964004972 Walker B; other site 698964004973 D-loop; other site 698964004974 H-loop/switch region; other site 698964004975 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698964004976 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698964004977 Walker A/P-loop; other site 698964004978 ATP binding site [chemical binding]; other site 698964004979 Q-loop/lid; other site 698964004980 ABC transporter signature motif; other site 698964004981 Walker B; other site 698964004982 D-loop; other site 698964004983 H-loop/switch region; other site 698964004984 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698964004985 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 698964004986 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 698964004987 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698964004988 catalytic residue [active] 698964004989 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 698964004990 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 698964004991 nucleotide binding site [chemical binding]; other site 698964004992 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 698964004993 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698964004994 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698964004995 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 698964004996 active site residue [active] 698964004997 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 698964004998 putative homodimer interface [polypeptide binding]; other site 698964004999 putative homotetramer interface [polypeptide binding]; other site 698964005000 putative allosteric switch controlling residues; other site 698964005001 putative metal binding site [ion binding]; other site 698964005002 putative homodimer-homodimer interface [polypeptide binding]; other site 698964005003 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 698964005004 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 698964005005 TrkA-N domain; Region: TrkA_N; pfam02254 698964005006 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 698964005007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698964005008 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 698964005009 active site 698964005010 tetramer interface [polypeptide binding]; other site 698964005011 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 698964005012 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698964005013 Mrr N-terminal domain; Region: Mrr_N; pfam14338 698964005014 Restriction endonuclease; Region: Mrr_cat; pfam04471 698964005015 Abi-like protein; Region: Abi_2; pfam07751 698964005016 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698964005017 Helix-turn-helix domain; Region: HTH_38; pfam13936 698964005018 Integrase core domain; Region: rve; pfam00665 698964005019 AAA ATPase domain; Region: AAA_16; pfam13191 698964005020 GTP-binding protein LepA; Provisional; Region: PRK05433 698964005021 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 698964005022 G1 box; other site 698964005023 putative GEF interaction site [polypeptide binding]; other site 698964005024 GTP/Mg2+ binding site [chemical binding]; other site 698964005025 Switch I region; other site 698964005026 G2 box; other site 698964005027 G3 box; other site 698964005028 Switch II region; other site 698964005029 G4 box; other site 698964005030 G5 box; other site 698964005031 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 698964005032 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 698964005033 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 698964005034 PemK-like protein; Region: PemK; pfam02452 698964005035 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 698964005036 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698964005037 DNA polymerase III, delta subunit; Region: holA; TIGR01128 698964005038 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 698964005039 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 698964005040 Competence protein; Region: Competence; pfam03772 698964005041 comEA protein; Region: comE; TIGR01259 698964005042 Helix-hairpin-helix motif; Region: HHH; pfam00633 698964005043 helix-hairpin-helix signature motif; other site 698964005044 EDD domain protein, DegV family; Region: DegV; TIGR00762 698964005045 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 698964005046 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698964005047 catalytic core [active] 698964005048 Oligomerisation domain; Region: Oligomerisation; cl00519 698964005049 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 698964005050 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 698964005051 active site 698964005052 (T/H)XGH motif; other site 698964005053 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 698964005054 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 698964005055 putative catalytic cysteine [active] 698964005056 gamma-glutamyl kinase; Provisional; Region: PRK05429 698964005057 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 698964005058 nucleotide binding site [chemical binding]; other site 698964005059 homotetrameric interface [polypeptide binding]; other site 698964005060 putative phosphate binding site [ion binding]; other site 698964005061 putative allosteric binding site; other site 698964005062 PUA domain; Region: PUA; pfam01472 698964005063 GTPase CgtA; Reviewed; Region: obgE; PRK12296 698964005064 GTP1/OBG; Region: GTP1_OBG; pfam01018 698964005065 Obg GTPase; Region: Obg; cd01898 698964005066 G1 box; other site 698964005067 GTP/Mg2+ binding site [chemical binding]; other site 698964005068 Switch I region; other site 698964005069 G2 box; other site 698964005070 G3 box; other site 698964005071 Switch II region; other site 698964005072 G4 box; other site 698964005073 G5 box; other site 698964005074 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 698964005075 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 698964005076 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 698964005077 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 698964005078 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698964005079 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 698964005080 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 698964005081 homodimer interface [polypeptide binding]; other site 698964005082 oligonucleotide binding site [chemical binding]; other site 698964005083 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 698964005084 active site 698964005085 multimer interface [polypeptide binding]; other site 698964005086 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 698964005087 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 698964005088 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698964005089 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 698964005090 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698964005091 active site 698964005092 HIGH motif; other site 698964005093 nucleotide binding site [chemical binding]; other site 698964005094 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 698964005095 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 698964005096 active site 698964005097 KMSKS motif; other site 698964005098 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 698964005099 tRNA binding surface [nucleotide binding]; other site 698964005100 anticodon binding site; other site 698964005101 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 698964005102 malate dehydrogenase; Provisional; Region: PRK05442 698964005103 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 698964005104 NAD(P) binding site [chemical binding]; other site 698964005105 dimer interface [polypeptide binding]; other site 698964005106 malate binding site [chemical binding]; other site 698964005107 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698964005108 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698964005109 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 698964005110 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 698964005111 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 698964005112 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698964005113 Walker A motif; other site 698964005114 ATP binding site [chemical binding]; other site 698964005115 Walker B motif; other site 698964005116 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 698964005117 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 698964005118 Glutamine amidotransferase class-I; Region: GATase; pfam00117 698964005119 glutamine binding [chemical binding]; other site 698964005120 catalytic triad [active] 698964005121 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 698964005122 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698964005123 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 698964005124 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 698964005125 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 698964005126 oligomer interface [polypeptide binding]; other site 698964005127 active site residues [active] 698964005128 Clp protease; Region: CLP_protease; pfam00574 698964005129 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 698964005130 oligomer interface [polypeptide binding]; other site 698964005131 active site residues [active] 698964005132 trigger factor; Provisional; Region: tig; PRK01490 698964005133 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 698964005134 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 698964005135 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 698964005136 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 698964005137 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 698964005138 catalytic residues [active] 698964005139 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 698964005140 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 698964005141 Zn binding site [ion binding]; other site 698964005142 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 698964005143 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698964005144 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 698964005145 apolar tunnel; other site 698964005146 heme binding site [chemical binding]; other site 698964005147 dimerization interface [polypeptide binding]; other site 698964005148 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 698964005149 active site 698964005150 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 698964005151 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698964005152 Walker A/P-loop; other site 698964005153 ATP binding site [chemical binding]; other site 698964005154 Q-loop/lid; other site 698964005155 ABC transporter signature motif; other site 698964005156 Walker B; other site 698964005157 D-loop; other site 698964005158 H-loop/switch region; other site 698964005159 ABC transporter; Region: ABC_tran_2; pfam12848 698964005160 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698964005161 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 698964005162 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698964005163 dimer interface [polypeptide binding]; other site 698964005164 ssDNA binding site [nucleotide binding]; other site 698964005165 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698964005166 Copper resistance protein D; Region: CopD; pfam05425 698964005167 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 698964005168 Protein of unknown function (DUF466); Region: DUF466; pfam04328 698964005169 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698964005170 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 698964005171 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 698964005172 NADP binding site [chemical binding]; other site 698964005173 dimer interface [polypeptide binding]; other site 698964005174 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698964005175 classical (c) SDRs; Region: SDR_c; cd05233 698964005176 NAD(P) binding site [chemical binding]; other site 698964005177 active site 698964005178 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 698964005179 catalytic site [active] 698964005180 putative active site [active] 698964005181 putative substrate binding site [chemical binding]; other site 698964005182 dimer interface [polypeptide binding]; other site 698964005183 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698964005184 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 698964005185 inhibitor site; inhibition site 698964005186 active site 698964005187 dimer interface [polypeptide binding]; other site 698964005188 catalytic residue [active] 698964005189 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 698964005190 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 698964005191 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 698964005192 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698964005193 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 698964005194 MULE transposase domain; Region: MULE; pfam10551 698964005195 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698964005196 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698964005197 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698964005198 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698964005199 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698964005200 non-specific DNA binding site [nucleotide binding]; other site 698964005201 salt bridge; other site 698964005202 sequence-specific DNA binding site [nucleotide binding]; other site 698964005203 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 698964005204 conserved cis-peptide bond; other site 698964005205 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 698964005206 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 698964005207 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 698964005208 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 698964005209 catalytic triad [active] 698964005210 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698964005211 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698964005212 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 698964005213 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 698964005214 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 698964005215 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698964005216 phosphate binding site [ion binding]; other site 698964005217 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 698964005218 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 698964005219 active site 2 [active] 698964005220 active site 1 [active] 698964005221 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 698964005222 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 698964005223 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 698964005224 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 698964005225 putative NAD(P) binding site [chemical binding]; other site 698964005226 active site 698964005227 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 698964005228 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 698964005229 active site 698964005230 Glucitol operon activator protein (GutM); Region: GutM; cl01890 698964005231 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 698964005232 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 698964005233 active site 698964005234 dimerization interface [polypeptide binding]; other site 698964005235 ribonuclease PH; Reviewed; Region: rph; PRK00173 698964005236 Ribonuclease PH; Region: RNase_PH_bact; cd11362 698964005237 hexamer interface [polypeptide binding]; other site 698964005238 active site 698964005239 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 698964005240 glutamate racemase; Provisional; Region: PRK00865 698964005241 Rhomboid family; Region: Rhomboid; cl11446 698964005242 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 698964005243 putative active site pocket [active] 698964005244 cleavage site 698964005245 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 698964005246 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 698964005247 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 698964005248 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 698964005249 active site 698964005250 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 698964005251 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698964005252 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698964005253 putative Mg++ binding site [ion binding]; other site 698964005254 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 698964005255 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698964005256 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 698964005257 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698964005258 active site 698964005259 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 698964005260 dimer interface [polypeptide binding]; other site 698964005261 putative active site [active] 698964005262 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 698964005263 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 698964005264 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 698964005265 phosphoserine phosphatase SerB; Region: serB; TIGR00338 698964005266 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698964005267 motif II; other site 698964005268 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 698964005269 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 698964005270 D-pathway; other site 698964005271 Putative ubiquinol binding site [chemical binding]; other site 698964005272 Low-spin heme (heme b) binding site [chemical binding]; other site 698964005273 Putative water exit pathway; other site 698964005274 Binuclear center (heme o3/CuB) [ion binding]; other site 698964005275 K-pathway; other site 698964005276 Putative proton exit pathway; other site 698964005277 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 698964005278 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 698964005279 dimer interface [polypeptide binding]; other site 698964005280 putative radical transfer pathway; other site 698964005281 diiron center [ion binding]; other site 698964005282 tyrosyl radical; other site 698964005283 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 698964005284 Ferritin-like domain; Region: Ferritin; pfam00210 698964005285 ferroxidase diiron center [ion binding]; other site 698964005286 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 698964005287 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 698964005288 Class I ribonucleotide reductase; Region: RNR_I; cd01679 698964005289 active site 698964005290 dimer interface [polypeptide binding]; other site 698964005291 catalytic residues [active] 698964005292 effector binding site; other site 698964005293 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 698964005294 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 698964005295 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 698964005296 catalytic residues [active] 698964005297 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 698964005298 active site lid residues [active] 698964005299 substrate binding pocket [chemical binding]; other site 698964005300 catalytic residues [active] 698964005301 substrate-Mg2+ binding site; other site 698964005302 aspartate-rich region 1; other site 698964005303 aspartate-rich region 2; other site 698964005304 phytoene desaturase; Region: crtI_fam; TIGR02734 698964005305 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698964005306 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 698964005307 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 698964005308 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 698964005309 homodimer interface [polypeptide binding]; other site 698964005310 NAD binding pocket [chemical binding]; other site 698964005311 ATP binding pocket [chemical binding]; other site 698964005312 Mg binding site [ion binding]; other site 698964005313 active-site loop [active] 698964005314 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 698964005315 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 698964005316 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 698964005317 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 698964005318 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 698964005319 Predicted transcriptional regulator [Transcription]; Region: COG2345 698964005320 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 698964005321 Thioredoxin; Region: Thioredoxin_4; cl17273 698964005322 Methylamine utilisation protein MauE; Region: MauE; pfam07291 698964005323 phosphoglucomutase; Validated; Region: PRK07564 698964005324 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 698964005325 active site 698964005326 substrate binding site [chemical binding]; other site 698964005327 metal binding site [ion binding]; metal-binding site 698964005328 CrcB-like protein; Region: CRCB; pfam02537 698964005329 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698964005330 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698964005331 FtsX-like permease family; Region: FtsX; pfam02687 698964005332 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698964005333 FtsX-like permease family; Region: FtsX; pfam02687 698964005334 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698964005335 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698964005336 Walker A/P-loop; other site 698964005337 ATP binding site [chemical binding]; other site 698964005338 Q-loop/lid; other site 698964005339 ABC transporter signature motif; other site 698964005340 Walker B; other site 698964005341 D-loop; other site 698964005342 H-loop/switch region; other site 698964005343 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 698964005344 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 698964005345 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 698964005346 hinge; other site 698964005347 active site 698964005348 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 698964005349 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 698964005350 GAF domain; Region: GAF_2; pfam13185 698964005351 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698964005352 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698964005353 DNA binding residues [nucleotide binding] 698964005354 dimerization interface [polypeptide binding]; other site 698964005355 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 698964005356 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 698964005357 dimer interface [polypeptide binding]; other site 698964005358 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698964005359 catalytic residue [active] 698964005360 serine O-acetyltransferase; Region: cysE; TIGR01172 698964005361 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 698964005362 trimer interface [polypeptide binding]; other site 698964005363 active site 698964005364 substrate binding site [chemical binding]; other site 698964005365 CoA binding site [chemical binding]; other site 698964005366 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698964005367 Coenzyme A binding pocket [chemical binding]; other site 698964005368 Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171 698964005369 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 698964005370 putative active site [active] 698964005371 metal binding site [ion binding]; metal-binding site 698964005372 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698964005373 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 698964005374 DNA methylase; Region: N6_N4_Mtase; pfam01555 698964005375 DNA methylase; Region: N6_N4_Mtase; pfam01555 698964005376 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 698964005377 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 698964005378 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 698964005379 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 698964005380 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 698964005381 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 698964005382 Walker A/P-loop; other site 698964005383 ATP binding site [chemical binding]; other site 698964005384 Q-loop/lid; other site 698964005385 ABC transporter signature motif; other site 698964005386 Walker B; other site 698964005387 D-loop; other site 698964005388 H-loop/switch region; other site 698964005389 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 698964005390 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698964005391 Walker A/P-loop; other site 698964005392 ATP binding site [chemical binding]; other site 698964005393 Q-loop/lid; other site 698964005394 ABC transporter signature motif; other site 698964005395 Walker B; other site 698964005396 D-loop; other site 698964005397 H-loop/switch region; other site 698964005398 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 698964005399 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 698964005400 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 698964005401 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 698964005402 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 698964005403 FMN binding site [chemical binding]; other site 698964005404 active site 698964005405 catalytic residues [active] 698964005406 substrate binding site [chemical binding]; other site 698964005407 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 698964005408 PhoU domain; Region: PhoU; pfam01895 698964005409 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 698964005410 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698964005411 Coenzyme A binding pocket [chemical binding]; other site 698964005412 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698964005413 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 698964005414 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 698964005415 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 698964005416 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 698964005417 heme-binding site [chemical binding]; other site 698964005418 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 698964005419 substrate binding site [chemical binding]; other site 698964005420 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 698964005421 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 698964005422 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698964005423 catalytic residue [active] 698964005424 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 698964005425 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 698964005426 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 698964005427 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 698964005428 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 698964005429 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 698964005430 dimerization interface [polypeptide binding]; other site 698964005431 putative ATP binding site [chemical binding]; other site 698964005432 amidophosphoribosyltransferase; Provisional; Region: PRK07847 698964005433 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 698964005434 active site 698964005435 tetramer interface [polypeptide binding]; other site 698964005436 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698964005437 active site 698964005438 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 698964005439 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 698964005440 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 698964005441 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698964005442 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698964005443 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698964005444 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698964005445 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698964005446 non-specific DNA binding site [nucleotide binding]; other site 698964005447 salt bridge; other site 698964005448 sequence-specific DNA binding site [nucleotide binding]; other site 698964005449 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 698964005450 catalytic residues [active] 698964005451 dimer interface [polypeptide binding]; other site 698964005452 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 698964005453 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698964005454 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 698964005455 ATP binding site [chemical binding]; other site 698964005456 active site 698964005457 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 698964005458 substrate binding site [chemical binding]; other site 698964005459 adenylosuccinate lyase; Region: purB; TIGR00928 698964005460 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 698964005461 tetramer interface [polypeptide binding]; other site 698964005462 aspartate aminotransferase; Provisional; Region: PRK05764 698964005463 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698964005464 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698964005465 homodimer interface [polypeptide binding]; other site 698964005466 catalytic residue [active] 698964005467 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 698964005468 TrkA-N domain; Region: TrkA_N; pfam02254 698964005469 TrkA-C domain; Region: TrkA_C; pfam02080 698964005470 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 698964005471 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 698964005472 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 698964005473 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 698964005474 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 698964005475 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 698964005476 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 698964005477 nucleotide binding site/active site [active] 698964005478 HIT family signature motif; other site 698964005479 catalytic residue [active] 698964005480 PGAP1-like protein; Region: PGAP1; pfam07819 698964005481 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698964005482 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698964005483 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698964005484 dimerization interface [polypeptide binding]; other site 698964005485 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698964005486 dimer interface [polypeptide binding]; other site 698964005487 phosphorylation site [posttranslational modification] 698964005488 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698964005489 ATP binding site [chemical binding]; other site 698964005490 Mg2+ binding site [ion binding]; other site 698964005491 G-X-G motif; other site 698964005492 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698964005493 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698964005494 active site 698964005495 phosphorylation site [posttranslational modification] 698964005496 intermolecular recognition site; other site 698964005497 dimerization interface [polypeptide binding]; other site 698964005498 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698964005499 DNA binding site [nucleotide binding] 698964005500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698964005501 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698964005502 putative substrate translocation pore; other site 698964005503 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698964005504 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698964005505 potential frameshift: common BLAST hit: gi|38234510|ref|NP_940277.1| xanthine/uracil permeases family protein 698964005506 xanthine permease; Region: pbuX; TIGR03173 698964005507 xanthine permease; Region: pbuX; TIGR03173 698964005508 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 698964005509 pyruvate dehydrogenase; Provisional; Region: PRK06546 698964005510 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 698964005511 PYR/PP interface [polypeptide binding]; other site 698964005512 dimer interface [polypeptide binding]; other site 698964005513 tetramer interface [polypeptide binding]; other site 698964005514 TPP binding site [chemical binding]; other site 698964005515 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698964005516 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 698964005517 TPP-binding site [chemical binding]; other site 698964005518 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698964005519 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 698964005520 Uncharacterized conserved protein [Function unknown]; Region: COG2966 698964005521 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698964005522 Uncharacterized conserved protein [Function unknown]; Region: COG3610 698964005523 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 698964005524 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 698964005525 active site 698964005526 homotetramer interface [polypeptide binding]; other site 698964005527 META domain; Region: META; cl01245 698964005528 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 698964005529 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 698964005530 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698964005531 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698964005532 DNA binding site [nucleotide binding] 698964005533 domain linker motif; other site 698964005534 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 698964005535 putative dimerization interface [polypeptide binding]; other site 698964005536 putative ligand binding site [chemical binding]; other site 698964005537 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698964005538 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 698964005539 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698964005540 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 698964005541 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698964005542 active site 698964005543 HIGH motif; other site 698964005544 nucleotide binding site [chemical binding]; other site 698964005545 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 698964005546 KMSKS motif; other site 698964005547 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 698964005548 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 698964005549 homotrimer interaction site [polypeptide binding]; other site 698964005550 zinc binding site [ion binding]; other site 698964005551 CDP-binding sites; other site 698964005552 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 698964005553 substrate binding site; other site 698964005554 dimer interface; other site 698964005555 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 698964005556 DNA repair protein RadA; Provisional; Region: PRK11823 698964005557 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 698964005558 Walker A motif; other site 698964005559 ATP binding site [chemical binding]; other site 698964005560 Walker B motif; other site 698964005561 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 698964005562 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 698964005563 active site clefts [active] 698964005564 zinc binding site [ion binding]; other site 698964005565 dimer interface [polypeptide binding]; other site 698964005566 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698964005567 endonuclease III; Region: ENDO3c; smart00478 698964005568 minor groove reading motif; other site 698964005569 helix-hairpin-helix signature motif; other site 698964005570 substrate binding pocket [chemical binding]; other site 698964005571 active site 698964005572 Uncharacterized conserved protein [Function unknown]; Region: COG2966 698964005573 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698964005574 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 698964005575 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 698964005576 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 698964005577 Clp amino terminal domain; Region: Clp_N; pfam02861 698964005578 Clp amino terminal domain; Region: Clp_N; pfam02861 698964005579 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698964005580 Walker A motif; other site 698964005581 ATP binding site [chemical binding]; other site 698964005582 Walker B motif; other site 698964005583 arginine finger; other site 698964005584 UvrB/uvrC motif; Region: UVR; pfam02151 698964005585 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698964005586 Walker A motif; other site 698964005587 ATP binding site [chemical binding]; other site 698964005588 Walker B motif; other site 698964005589 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 698964005590 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 698964005591 oligomer interface [polypeptide binding]; other site 698964005592 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698964005593 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698964005594 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 698964005595 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 698964005596 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 698964005597 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 698964005598 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 698964005599 active site 698964005600 catalytic motif [active] 698964005601 Zn binding site [ion binding]; other site 698964005602 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 698964005603 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 698964005604 Nucleoside recognition; Region: Gate; pfam07670 698964005605 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 698964005606 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 698964005607 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 698964005608 dimer interface [polypeptide binding]; other site 698964005609 putative anticodon binding site; other site 698964005610 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698964005611 motif 1; other site 698964005612 dimer interface [polypeptide binding]; other site 698964005613 active site 698964005614 motif 2; other site 698964005615 motif 3; other site 698964005616 YcaO-like family; Region: YcaO; pfam02624 698964005617 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 698964005618 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 698964005619 NADPH bind site [chemical binding]; other site 698964005620 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 698964005621 dimer interface [polypeptide binding]; other site 698964005622 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 698964005623 SpaB C-terminal domain; Region: SpaB_C; pfam14028 698964005624 YcaO-like family; Region: YcaO; pfam02624 698964005625 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 698964005626 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698964005627 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698964005628 Walker A/P-loop; other site 698964005629 ATP binding site [chemical binding]; other site 698964005630 Q-loop/lid; other site 698964005631 ABC transporter signature motif; other site 698964005632 Walker B; other site 698964005633 D-loop; other site 698964005634 H-loop/switch region; other site 698964005635 potential frameshift: common BLAST hit: gi|62389924|ref|YP_225326.1| transposase 698964005636 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698964005637 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698964005638 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 698964005639 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 698964005640 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 698964005641 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 698964005642 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 698964005643 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698964005644 active site 698964005645 KMSKS motif; other site 698964005646 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 698964005647 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 698964005648 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 698964005649 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 698964005650 catalytic center binding site [active] 698964005651 ATP binding site [chemical binding]; other site 698964005652 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 698964005653 homooctamer interface [polypeptide binding]; other site 698964005654 active site 698964005655 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 698964005656 dihydropteroate synthase; Region: DHPS; TIGR01496 698964005657 substrate binding pocket [chemical binding]; other site 698964005658 dimer interface [polypeptide binding]; other site 698964005659 inhibitor binding site; inhibition site 698964005660 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 698964005661 homodecamer interface [polypeptide binding]; other site 698964005662 GTP cyclohydrolase I; Provisional; Region: PLN03044 698964005663 active site 698964005664 putative catalytic site residues [active] 698964005665 zinc binding site [ion binding]; other site 698964005666 GTP-CH-I/GFRP interaction surface; other site 698964005667 FtsH Extracellular; Region: FtsH_ext; pfam06480 698964005668 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 698964005669 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698964005670 Walker A motif; other site 698964005671 ATP binding site [chemical binding]; other site 698964005672 Walker B motif; other site 698964005673 arginine finger; other site 698964005674 Peptidase family M41; Region: Peptidase_M41; pfam01434 698964005675 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698964005676 active site 698964005677 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 698964005678 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 698964005679 Ligand Binding Site [chemical binding]; other site 698964005680 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 698964005681 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 698964005682 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 698964005683 dimer interface [polypeptide binding]; other site 698964005684 substrate binding site [chemical binding]; other site 698964005685 metal binding sites [ion binding]; metal-binding site 698964005686 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698964005687 active site residue [active] 698964005688 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698964005689 MarR family; Region: MarR_2; pfam12802 698964005690 potential frameshift: common BLAST hit: gi|38234573|ref|NP_940340.1| peptide synthase 698964005691 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698964005692 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 698964005693 acyl-activating enzyme (AAE) consensus motif; other site 698964005694 AMP binding site [chemical binding]; other site 698964005695 active site 698964005696 CoA binding site [chemical binding]; other site 698964005697 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698964005698 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 698964005699 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698964005700 putative trimer interface [polypeptide binding]; other site 698964005701 putative CoA binding site [chemical binding]; other site 698964005702 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698964005703 putative trimer interface [polypeptide binding]; other site 698964005704 putative CoA binding site [chemical binding]; other site 698964005705 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 698964005706 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698964005707 active site 698964005708 catalytic site [active] 698964005709 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 698964005710 potential frameshift: common BLAST hit: gi|38234579|ref|NP_940346.1| exported lipase 698964005711 Secretory lipase; Region: LIP; pfam03583 698964005712 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 698964005713 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 698964005714 active site 698964005715 catalytic triad [active] 698964005716 oxyanion hole [active] 698964005717 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 698964005718 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 698964005719 ring oligomerisation interface [polypeptide binding]; other site 698964005720 ATP/Mg binding site [chemical binding]; other site 698964005721 stacking interactions; other site 698964005722 hinge regions; other site 698964005723 potential frameshift: common BLAST hit: gi|336326698|ref|YP_004606664.1| transposase for insertion sequence element 698964005724 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 698964005725 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698964005726 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698964005727 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698964005728 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698964005729 MULE transposase domain; Region: MULE; pfam10551 698964005730 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 698964005731 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 698964005732 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 698964005733 FMN binding site [chemical binding]; other site 698964005734 active site 698964005735 substrate binding site [chemical binding]; other site 698964005736 catalytic residue [active] 698964005737 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 698964005738 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698964005739 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698964005740 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698964005741 Walker A/P-loop; other site 698964005742 ATP binding site [chemical binding]; other site 698964005743 Q-loop/lid; other site 698964005744 ABC transporter signature motif; other site 698964005745 Walker B; other site 698964005746 D-loop; other site 698964005747 H-loop/switch region; other site 698964005748 intracellular protease, PfpI family; Region: PfpI; TIGR01382 698964005749 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 698964005750 proposed catalytic triad [active] 698964005751 conserved cys residue [active] 698964005752 potential frameshift: common BLAST hit: gi|336326698|ref|YP_004606664.1| transposase for insertion sequence element 698964005753 potential frameshift: common BLAST hit: gi|68536874|ref|YP_251579.1| transposase IS3525 698964005754 MULE transposase domain; Region: MULE; pfam10551 698964005755 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698964005756 HTH-like domain; Region: HTH_21; pfam13276 698964005757 potential frameshift: common BLAST hit: gi|227832249|ref|YP_002833956.1| transposase 698964005758 hypothetical protein; Provisional; Region: PRK07907 698964005759 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 698964005760 active site 698964005761 metal binding site [ion binding]; metal-binding site 698964005762 dimer interface [polypeptide binding]; other site 698964005763 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 698964005764 carboxylate-amine ligase; Provisional; Region: PRK13517 698964005765 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 698964005766 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 698964005767 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 698964005768 active site 698964005769 catalytic residues [active] 698964005770 metal binding site [ion binding]; metal-binding site 698964005771 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 698964005772 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698964005773 Coenzyme A binding pocket [chemical binding]; other site 698964005774 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 698964005775 putative catalytic site [active] 698964005776 putative metal binding site [ion binding]; other site 698964005777 putative phosphate binding site [ion binding]; other site 698964005778 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 698964005779 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 698964005780 putative active site [active] 698964005781 catalytic site [active] 698964005782 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 698964005783 putative active site [active] 698964005784 catalytic site [active] 698964005785 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 698964005786 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698964005787 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698964005788 Walker A/P-loop; other site 698964005789 ATP binding site [chemical binding]; other site 698964005790 Q-loop/lid; other site 698964005791 ABC transporter signature motif; other site 698964005792 Walker B; other site 698964005793 D-loop; other site 698964005794 H-loop/switch region; other site 698964005795 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698964005796 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698964005797 substrate binding pocket [chemical binding]; other site 698964005798 membrane-bound complex binding site; other site 698964005799 hinge residues; other site 698964005800 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698964005801 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698964005802 active site 698964005803 ATP binding site [chemical binding]; other site 698964005804 substrate binding site [chemical binding]; other site 698964005805 activation loop (A-loop); other site 698964005806 propionate/acetate kinase; Provisional; Region: PRK12379 698964005807 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 698964005808 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 698964005809 ferredoxin-NADP+ reductase; Region: PLN02852 698964005810 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698964005811 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698964005812 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 698964005813 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698964005814 active site 698964005815 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698964005816 putative active site [active] 698964005817 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 698964005818 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 698964005819 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 698964005820 GDP-binding site [chemical binding]; other site 698964005821 ACT binding site; other site 698964005822 IMP binding site; other site 698964005823 Predicted membrane protein [Function unknown]; Region: COG4129 698964005824 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 698964005825 chromosome segregation protein; Provisional; Region: PRK03918 698964005826 Predicted membrane protein [Function unknown]; Region: COG4129 698964005827 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 698964005828 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 698964005829 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 698964005830 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698964005831 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 698964005832 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 698964005833 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698964005834 ATP binding site [chemical binding]; other site 698964005835 putative Mg++ binding site [ion binding]; other site 698964005836 potential frameshift: common BLAST hit: gi|336326413|ref|YP_004606379.1| transposase for insertion sequence element 698964005837 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698964005838 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698964005839 Transposase; Region: HTH_Tnp_1; cl17663 698964005840 putative transposase OrfB; Reviewed; Region: PHA02517 698964005841 HTH-like domain; Region: HTH_21; pfam13276 698964005842 Integrase core domain; Region: rve; pfam00665 698964005843 Integrase core domain; Region: rve_2; pfam13333 698964005844 Helix-turn-helix domain; Region: HTH_28; pfam13518 698964005845 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 698964005846 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 698964005847 active site 698964005848 intersubunit interface [polypeptide binding]; other site 698964005849 zinc binding site [ion binding]; other site 698964005850 Na+ binding site [ion binding]; other site 698964005851 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 698964005852 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698964005853 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698964005854 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698964005855 active site 698964005856 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 698964005857 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 698964005858 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698964005859 active site residue [active] 698964005860 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 698964005861 active site residue [active] 698964005862 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 698964005863 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 698964005864 Clp amino terminal domain; Region: Clp_N; pfam02861 698964005865 Clp amino terminal domain; Region: Clp_N; pfam02861 698964005866 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698964005867 Walker A motif; other site 698964005868 ATP binding site [chemical binding]; other site 698964005869 Walker B motif; other site 698964005870 arginine finger; other site 698964005871 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698964005872 Walker A motif; other site 698964005873 ATP binding site [chemical binding]; other site 698964005874 Walker B motif; other site 698964005875 arginine finger; other site 698964005876 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 698964005877 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 698964005878 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698964005879 ABC transporter; Region: ABC_tran; pfam00005 698964005880 Q-loop/lid; other site 698964005881 ABC transporter signature motif; other site 698964005882 Walker B; other site 698964005883 D-loop; other site 698964005884 H-loop/switch region; other site 698964005885 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698964005886 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698964005887 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698964005888 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 698964005889 EamA-like transporter family; Region: EamA; pfam00892 698964005890 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698964005891 EamA-like transporter family; Region: EamA; pfam00892 698964005892 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 698964005893 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 698964005894 FAD binding pocket [chemical binding]; other site 698964005895 FAD binding motif [chemical binding]; other site 698964005896 phosphate binding motif [ion binding]; other site 698964005897 beta-alpha-beta structure motif; other site 698964005898 NAD binding pocket [chemical binding]; other site 698964005899 Predicted amidohydrolase [General function prediction only]; Region: COG0388 698964005900 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 698964005901 putative active site [active] 698964005902 catalytic triad [active] 698964005903 putative dimer interface [polypeptide binding]; other site 698964005904 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 698964005905 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 698964005906 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 698964005907 NAD binding site [chemical binding]; other site 698964005908 substrate binding site [chemical binding]; other site 698964005909 catalytic Zn binding site [ion binding]; other site 698964005910 tetramer interface [polypeptide binding]; other site 698964005911 structural Zn binding site [ion binding]; other site 698964005912 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 698964005913 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698964005914 NAD(P) binding site [chemical binding]; other site 698964005915 catalytic residues [active] 698964005916 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 698964005917 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 698964005918 DNA binding residues [nucleotide binding] 698964005919 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698964005920 putative dimer interface [polypeptide binding]; other site 698964005921 chaperone protein DnaJ; Provisional; Region: PRK14279 698964005922 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698964005923 HSP70 interaction site [polypeptide binding]; other site 698964005924 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 698964005925 Zn binding sites [ion binding]; other site 698964005926 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 698964005927 dimer interface [polypeptide binding]; other site 698964005928 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 698964005929 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 698964005930 dimer interface [polypeptide binding]; other site 698964005931 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 698964005932 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 698964005933 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 698964005934 nucleotide binding site [chemical binding]; other site 698964005935 NEF interaction site [polypeptide binding]; other site 698964005936 SBD interface [polypeptide binding]; other site 698964005937 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698964005938 PAS domain; Region: PAS_9; pfam13426 698964005939 putative active site [active] 698964005940 heme pocket [chemical binding]; other site 698964005941 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698964005942 Domain of unknown function DUF20; Region: UPF0118; pfam01594 698964005943 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698964005944 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 698964005945 Walker A/P-loop; other site 698964005946 ATP binding site [chemical binding]; other site 698964005947 Q-loop/lid; other site 698964005948 ABC transporter signature motif; other site 698964005949 Walker B; other site 698964005950 D-loop; other site 698964005951 H-loop/switch region; other site 698964005952 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698964005953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698964005954 dimer interface [polypeptide binding]; other site 698964005955 conserved gate region; other site 698964005956 putative PBP binding loops; other site 698964005957 ABC-ATPase subunit interface; other site 698964005958 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698964005959 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 698964005960 Walker A/P-loop; other site 698964005961 ATP binding site [chemical binding]; other site 698964005962 Q-loop/lid; other site 698964005963 ABC transporter signature motif; other site 698964005964 Walker B; other site 698964005965 D-loop; other site 698964005966 H-loop/switch region; other site 698964005967 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698964005968 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698964005969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698964005970 dimer interface [polypeptide binding]; other site 698964005971 conserved gate region; other site 698964005972 putative PBP binding loops; other site 698964005973 ABC-ATPase subunit interface; other site 698964005974 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698964005975 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 698964005976 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 698964005977 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 698964005978 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 698964005979 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 698964005980 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 698964005981 dimerization interface [polypeptide binding]; other site 698964005982 ATP binding site [chemical binding]; other site 698964005983 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 698964005984 dimerization interface [polypeptide binding]; other site 698964005985 ATP binding site [chemical binding]; other site 698964005986 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 698964005987 putative active site [active] 698964005988 catalytic triad [active] 698964005989 potential frameshift: common BLAST hit: gi|32479398|ref|NP_862251.1| Tnp1250a 698964005990 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698964005991 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698964005992 Integrase core domain; Region: rve; pfam00665 698964005993 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 698964005994 FAD binding pocket [chemical binding]; other site 698964005995 FAD binding motif [chemical binding]; other site 698964005996 phosphate binding motif [ion binding]; other site 698964005997 NAD binding pocket [chemical binding]; other site 698964005998 Siderophore-interacting protein; Region: SIP; pfam04954 698964005999 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698964006000 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698964006001 Walker A/P-loop; other site 698964006002 ATP binding site [chemical binding]; other site 698964006003 Q-loop/lid; other site 698964006004 ABC transporter signature motif; other site 698964006005 Walker B; other site 698964006006 D-loop; other site 698964006007 H-loop/switch region; other site 698964006008 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698964006009 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698964006010 ABC-ATPase subunit interface; other site 698964006011 dimer interface [polypeptide binding]; other site 698964006012 putative PBP binding regions; other site 698964006013 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698964006014 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698964006015 ABC-ATPase subunit interface; other site 698964006016 dimer interface [polypeptide binding]; other site 698964006017 putative PBP binding regions; other site 698964006018 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 698964006019 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698964006020 siderophore binding site; other site 698964006021 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 698964006022 ferredoxin-NADP+ reductase; Region: PLN02852 698964006023 Permease; Region: Permease; cl00510 698964006024 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 698964006025 4Fe-4S binding domain; Region: Fer4; cl02805 698964006026 Cysteine-rich domain; Region: CCG; pfam02754 698964006027 Cysteine-rich domain; Region: CCG; pfam02754 698964006028 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 698964006029 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 698964006030 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 698964006031 putative NAD(P) binding site [chemical binding]; other site 698964006032 catalytic Zn binding site [ion binding]; other site 698964006033 aminotransferase AlaT; Validated; Region: PRK09265 698964006034 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698964006035 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698964006036 homodimer interface [polypeptide binding]; other site 698964006037 catalytic residue [active] 698964006038 YibE/F-like protein; Region: YibE_F; pfam07907 698964006039 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 698964006040 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 698964006041 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 698964006042 dimer interface [polypeptide binding]; other site 698964006043 putative anticodon binding site; other site 698964006044 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698964006045 motif 1; other site 698964006046 dimer interface [polypeptide binding]; other site 698964006047 active site 698964006048 motif 2; other site 698964006049 motif 3; other site 698964006050 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698964006051 Protein of unknown function (DUF998); Region: DUF998; pfam06197 698964006052 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 698964006053 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 698964006054 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 698964006055 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 698964006056 trimer interface [polypeptide binding]; other site 698964006057 active site 698964006058 Prophage antirepressor [Transcription]; Region: COG3617 698964006059 BRO family, N-terminal domain; Region: Bro-N; smart01040 698964006060 Abi-like protein; Region: Abi_2; cl01988 698964006061 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 698964006062 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698964006063 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698964006064 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698964006065 Walker A/P-loop; other site 698964006066 ATP binding site [chemical binding]; other site 698964006067 Q-loop/lid; other site 698964006068 ABC transporter signature motif; other site 698964006069 Walker B; other site 698964006070 D-loop; other site 698964006071 H-loop/switch region; other site 698964006072 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698964006073 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698964006074 Walker A/P-loop; other site 698964006075 ATP binding site [chemical binding]; other site 698964006076 Q-loop/lid; other site 698964006077 ABC transporter signature motif; other site 698964006078 Walker B; other site 698964006079 D-loop; other site 698964006080 H-loop/switch region; other site 698964006081 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 698964006082 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 698964006083 active site 698964006084 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 698964006085 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698964006086 Condensation domain; Region: Condensation; pfam00668 698964006087 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698964006088 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698964006089 Condensation domain; Region: Condensation; pfam00668 698964006090 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698964006091 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698964006092 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698964006093 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 698964006094 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 698964006095 Condensation domain; Region: Condensation; pfam00668 698964006096 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698964006097 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 698964006098 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 698964006099 acyl-activating enzyme (AAE) consensus motif; other site 698964006100 AMP binding site [chemical binding]; other site 698964006101 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698964006102 Condensation domain; Region: Condensation; pfam00668 698964006103 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698964006104 Phosphopantetheine attachment site; Region: PP-binding; cl09936 698964006105 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698964006106 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 698964006107 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698964006108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698964006109 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698964006110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698964006111 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698964006112 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 698964006113 Walker A/P-loop; other site 698964006114 ATP binding site [chemical binding]; other site 698964006115 Q-loop/lid; other site 698964006116 ABC transporter signature motif; other site 698964006117 Walker B; other site 698964006118 D-loop; other site 698964006119 H-loop/switch region; other site 698964006120 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698964006121 Walker A/P-loop; other site 698964006122 ATP binding site [chemical binding]; other site 698964006123 Q-loop/lid; other site 698964006124 ABC transporter signature motif; other site 698964006125 Walker B; other site 698964006126 D-loop; other site 698964006127 H-loop/switch region; other site 698964006128 metabolite-proton symporter; Region: 2A0106; TIGR00883 698964006129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698964006130 putative substrate translocation pore; other site 698964006131 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 698964006132 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 698964006133 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 698964006134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698964006135 putative substrate translocation pore; other site 698964006136 YwiC-like protein; Region: YwiC; pfam14256 698964006137 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 698964006138 VanW like protein; Region: VanW; pfam04294 698964006139 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 698964006140 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 698964006141 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 698964006142 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698964006143 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 698964006144 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 698964006145 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698964006146 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698964006147 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 698964006148 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698964006149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698964006150 S-adenosylmethionine binding site [chemical binding]; other site 698964006151 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 698964006152 active site 698964006153 substrate-binding site [chemical binding]; other site 698964006154 metal-binding site [ion binding] 698964006155 GTP binding site [chemical binding]; other site 698964006156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698964006157 S-adenosylmethionine binding site [chemical binding]; other site 698964006158 LabA_like proteins; Region: LabA_like; cd06167 698964006159 putative metal binding site [ion binding]; other site 698964006160 MMPL family; Region: MMPL; pfam03176 698964006161 Protein of unknown function (DUF496); Region: DUF496; cl09955 698964006162 MMPL family; Region: MMPL; pfam03176 698964006163 Predicted integral membrane protein [Function unknown]; Region: COG0392 698964006164 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 698964006165 TQXA domain; Region: TQXA_dom; TIGR03934 698964006166 Fibronectin-binding protein signal sequence; Region: Fb_signal; pfam08341 698964006167 TQXA domain; Region: TQXA_dom; TIGR03934 698964006168 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 698964006169 active site 698964006170 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698964006171 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698964006172 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698964006173 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 698964006174 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 698964006175 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 698964006176 active site 698964006177 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 698964006178 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 698964006179 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 698964006180 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 698964006181 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 698964006182 acyl-activating enzyme (AAE) consensus motif; other site 698964006183 active site 698964006184 Cutinase; Region: Cutinase; pfam01083 698964006185 Putative esterase; Region: Esterase; pfam00756 698964006186 S-formylglutathione hydrolase; Region: PLN02442 698964006187 LGFP repeat; Region: LGFP; pfam08310 698964006188 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 698964006189 LGFP repeat; Region: LGFP; pfam08310 698964006190 LGFP repeat; Region: LGFP; pfam08310 698964006191 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 698964006192 Predicted esterase [General function prediction only]; Region: COG0627 698964006193 S-formylglutathione hydrolase; Region: PLN02442 698964006194 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 698964006195 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 698964006196 UbiA prenyltransferase family; Region: UbiA; pfam01040 698964006197 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 698964006198 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698964006199 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 698964006200 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 698964006201 active site 698964006202 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 698964006203 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698964006204 NAD(P) binding site [chemical binding]; other site 698964006205 catalytic residues [active] 698964006206 BCCT family transporter; Region: BCCT; cl00569 698964006207 choline dehydrogenase; Validated; Region: PRK02106 698964006208 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 698964006209 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 698964006210 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698964006211 UDP-galactopyranose mutase; Region: GLF; pfam03275 698964006212 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 698964006213 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698964006214 Integrase core domain; Region: rve; pfam00665 698964006215 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 698964006216 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 698964006217 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698964006218 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698964006219 Walker A/P-loop; other site 698964006220 ATP binding site [chemical binding]; other site 698964006221 Q-loop/lid; other site 698964006222 ABC transporter signature motif; other site 698964006223 Walker B; other site 698964006224 D-loop; other site 698964006225 H-loop/switch region; other site 698964006226 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698964006227 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698964006228 Walker A/P-loop; other site 698964006229 ATP binding site [chemical binding]; other site 698964006230 Q-loop/lid; other site 698964006231 ABC transporter signature motif; other site 698964006232 Walker B; other site 698964006233 D-loop; other site 698964006234 H-loop/switch region; other site 698964006235 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698964006236 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698964006237 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698964006238 Walker A/P-loop; other site 698964006239 ATP binding site [chemical binding]; other site 698964006240 Q-loop/lid; other site 698964006241 ABC transporter signature motif; other site 698964006242 Walker B; other site 698964006243 D-loop; other site 698964006244 H-loop/switch region; other site 698964006245 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698964006246 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698964006247 Walker A/P-loop; other site 698964006248 ATP binding site [chemical binding]; other site 698964006249 Q-loop/lid; other site 698964006250 ABC transporter signature motif; other site 698964006251 Walker B; other site 698964006252 D-loop; other site 698964006253 H-loop/switch region; other site 698964006254 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698964006255 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698964006256 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 698964006257 HTH-like domain; Region: HTH_21; pfam13276 698964006258 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698964006259 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698964006260 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698964006261 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 698964006262 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 698964006263 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698964006264 non-specific DNA binding site [nucleotide binding]; other site 698964006265 salt bridge; other site 698964006266 sequence-specific DNA binding site [nucleotide binding]; other site 698964006267 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698964006268 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 698964006269 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 698964006270 amidase catalytic site [active] 698964006271 Zn binding residues [ion binding]; other site 698964006272 substrate binding site [chemical binding]; other site 698964006273 LGFP repeat; Region: LGFP; pfam08310 698964006274 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 698964006275 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 698964006276 cardiolipin synthetase; Reviewed; Region: PRK12452 698964006277 Predicted ATPases [General function prediction only]; Region: COG1106 698964006278 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698964006279 Walker A/P-loop; other site 698964006280 ATP binding site [chemical binding]; other site 698964006281 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698964006282 Walker B; other site 698964006283 D-loop; other site 698964006284 H-loop/switch region; other site 698964006285 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698964006286 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698964006287 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698964006288 Walker A/P-loop; other site 698964006289 ATP binding site [chemical binding]; other site 698964006290 Q-loop/lid; other site 698964006291 ABC transporter signature motif; other site 698964006292 Walker B; other site 698964006293 D-loop; other site 698964006294 H-loop/switch region; other site 698964006295 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698964006296 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 698964006297 siderophore binding site; other site 698964006298 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698964006299 ABC-ATPase subunit interface; other site 698964006300 dimer interface [polypeptide binding]; other site 698964006301 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698964006302 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698964006303 ABC-ATPase subunit interface; other site 698964006304 putative PBP binding regions; other site 698964006305 glycerol kinase; Provisional; Region: glpK; PRK00047 698964006306 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 698964006307 nucleotide binding site [chemical binding]; other site 698964006308 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 698964006309 amphipathic channel; other site 698964006310 Asn-Pro-Ala signature motifs; other site 698964006311 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 698964006312 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 698964006313 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 698964006314 putative acyl-acceptor binding pocket; other site 698964006315 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698964006316 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698964006317 active site 698964006318 motif I; other site 698964006319 motif II; other site 698964006320 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698964006321 seryl-tRNA synthetase; Provisional; Region: PRK05431 698964006322 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 698964006323 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 698964006324 dimer interface [polypeptide binding]; other site 698964006325 active site 698964006326 motif 1; other site 698964006327 motif 2; other site 698964006328 motif 3; other site 698964006329 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 698964006330 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698964006331 DNA-binding site [nucleotide binding]; DNA binding site 698964006332 UTRA domain; Region: UTRA; pfam07702 698964006333 Septum formation; Region: Septum_form; pfam13845 698964006334 Septum formation; Region: Septum_form; pfam13845 698964006335 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 698964006336 AAA domain; Region: AAA_14; pfam13173 698964006337 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 698964006338 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698964006339 catalytic core [active] 698964006340 prephenate dehydratase; Provisional; Region: PRK11898 698964006341 Prephenate dehydratase; Region: PDT; pfam00800 698964006342 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 698964006343 putative L-Phe binding site [chemical binding]; other site 698964006344 Amidase; Region: Amidase; cl11426 698964006345 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 698964006346 CAAX protease self-immunity; Region: Abi; pfam02517 698964006347 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 698964006348 Transcriptional regulator [Transcription]; Region: LytR; COG1316 698964006349 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 698964006350 amino acid carrier protein; Region: agcS; TIGR00835 698964006351 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698964006352 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 698964006353 catalytic triad [active] 698964006354 catalytic triad [active] 698964006355 oxyanion hole [active] 698964006356 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 698964006357 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 698964006358 putative active site [active] 698964006359 catalytic site [active] 698964006360 putative metal binding site [ion binding]; other site 698964006361 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 698964006362 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 698964006363 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698964006364 NAD binding site [chemical binding]; other site 698964006365 dimer interface [polypeptide binding]; other site 698964006366 substrate binding site [chemical binding]; other site 698964006367 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 698964006368 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 698964006369 motif I; other site 698964006370 active site 698964006371 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698964006372 motif II; other site 698964006373 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698964006374 methionine sulfoxide reductase A; Provisional; Region: PRK00058 698964006375 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 698964006376 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 698964006377 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 698964006378 Predicted flavoprotein [General function prediction only]; Region: COG0431 698964006379 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698964006380 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 698964006381 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 698964006382 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 698964006383 Lsr2; Region: Lsr2; pfam11774 698964006384 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698964006385 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698964006386 active site 698964006387 phosphorylation site [posttranslational modification] 698964006388 intermolecular recognition site; other site 698964006389 dimerization interface [polypeptide binding]; other site 698964006390 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698964006391 DNA binding residues [nucleotide binding] 698964006392 dimerization interface [polypeptide binding]; other site 698964006393 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698964006394 Histidine kinase; Region: HisKA_3; pfam07730 698964006395 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698964006396 ATP binding site [chemical binding]; other site 698964006397 Mg2+ binding site [ion binding]; other site 698964006398 G-X-G motif; other site 698964006399 Domain of unknown function (DUF2020); Region: DUF2020; pfam09449 698964006400 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 698964006401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698964006402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698964006403 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 698964006404 active site 698964006405 catalytic site [active] 698964006406 putative inner membrane protein translocase component YidC; Validated; Region: PRK00247 698964006407 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 698964006408 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698964006409 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698964006410 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698964006411 Ligand Binding Site [chemical binding]; other site 698964006412 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698964006413 Ligand Binding Site [chemical binding]; other site 698964006414 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 698964006415 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 698964006416 probable active site [active] 698964006417 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698964006418 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698964006419 Walker A/P-loop; other site 698964006420 ATP binding site [chemical binding]; other site 698964006421 Q-loop/lid; other site 698964006422 ABC transporter signature motif; other site 698964006423 Walker B; other site 698964006424 D-loop; other site 698964006425 H-loop/switch region; other site 698964006426 Predicted transcriptional regulators [Transcription]; Region: COG1725 698964006427 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698964006428 DNA-binding site [nucleotide binding]; DNA binding site 698964006429 LabA_like proteins; Region: LabA_like; cd06167 698964006430 putative metal binding site [ion binding]; other site 698964006431 Uncharacterized conserved protein [Function unknown]; Region: COG1432 698964006432 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 698964006433 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698964006434 catalytic residues [active] 698964006435 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698964006436 metal-binding site [ion binding] 698964006437 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 698964006438 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698964006439 metal-binding site [ion binding] 698964006440 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698964006441 Soluble P-type ATPase [General function prediction only]; Region: COG4087 698964006442 benzoate transport; Region: 2A0115; TIGR00895 698964006443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698964006444 putative substrate translocation pore; other site 698964006445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698964006446 replicative DNA helicase; Provisional; Region: PRK05636 698964006447 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 698964006448 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 698964006449 Walker A motif; other site 698964006450 ATP binding site [chemical binding]; other site 698964006451 Walker B motif; other site 698964006452 DNA binding loops [nucleotide binding] 698964006453 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 698964006454 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 698964006455 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 698964006456 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 698964006457 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698964006458 dimer interface [polypeptide binding]; other site 698964006459 ssDNA binding site [nucleotide binding]; other site 698964006460 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698964006461 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 698964006462 Predicted integral membrane protein [Function unknown]; Region: COG5650 698964006463 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 698964006464 Transglycosylase; Region: Transgly; pfam00912 698964006465 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698964006466 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 698964006467 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698964006468 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698964006469 Ligand Binding Site [chemical binding]; other site 698964006470 classical (c) SDRs; Region: SDR_c; cd05233 698964006471 short chain dehydrogenase; Provisional; Region: PRK08219 698964006472 NAD(P) binding site [chemical binding]; other site 698964006473 active site 698964006474 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698964006475 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698964006476 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 698964006477 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 698964006478 active site residue [active] 698964006479 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 698964006480 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 698964006481 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 698964006482 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 698964006483 dimerization interface [polypeptide binding]; other site 698964006484 DPS ferroxidase diiron center [ion binding]; other site 698964006485 ion pore; other site 698964006486 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 698964006487 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 698964006488 putative DNA binding site [nucleotide binding]; other site 698964006489 catalytic residue [active] 698964006490 putative H2TH interface [polypeptide binding]; other site 698964006491 putative catalytic residues [active] 698964006492 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698964006493 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 698964006494 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 698964006495 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 698964006496 putative substrate binding site [chemical binding]; other site 698964006497 putative ATP binding site [chemical binding]; other site 698964006498 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 698964006499 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 698964006500 active site 698964006501 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 698964006502 AAA domain; Region: AAA_31; pfam13614 698964006503 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698964006504 P-loop; other site 698964006505 Magnesium ion binding site [ion binding]; other site 698964006506 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698964006507 Magnesium ion binding site [ion binding]; other site 698964006508 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 698964006509 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 698964006510 putative ligand binding residues [chemical binding]; other site 698964006511 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698964006512 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698964006513 ABC-ATPase subunit interface; other site 698964006514 dimer interface [polypeptide binding]; other site 698964006515 putative PBP binding regions; other site 698964006516 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698964006517 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698964006518 Walker A/P-loop; other site 698964006519 ATP binding site [chemical binding]; other site 698964006520 Q-loop/lid; other site 698964006521 ABC transporter signature motif; other site 698964006522 Walker B; other site 698964006523 D-loop; other site 698964006524 H-loop/switch region; other site 698964006525 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 698964006526 dimer interface [polypeptide binding]; other site 698964006527 [2Fe-2S] cluster binding site [ion binding]; other site 698964006528 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698964006529 Divergent AAA domain; Region: AAA_4; pfam04326 698964006530 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698964006531 Divergent AAA domain; Region: AAA_4; pfam04326 698964006532 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698964006533 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698964006534 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 698964006535 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 698964006536 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698964006537 ATP binding site [chemical binding]; other site 698964006538 putative Mg++ binding site [ion binding]; other site 698964006539 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 698964006540 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698964006541 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 698964006542 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698964006543 potential frameshift: common BLAST hit: gi|38234849|ref|NP_940616.1| type I restriction/modification system DNA methylase 698964006544 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 698964006545 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698964006546 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 698964006547 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698964006548 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 698964006549 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698964006550 HsdM N-terminal domain; Region: HsdM_N; pfam12161 698964006551 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 698964006552 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698964006553 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 698964006554 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 698964006555 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 698964006556 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 698964006557 DNA binding residues [nucleotide binding] 698964006558 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 698964006559 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 698964006560 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 698964006561 Uncharacterized conserved protein [Function unknown]; Region: COG3410 698964006562 Fic family protein [Function unknown]; Region: COG3177 698964006563 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 698964006564 Fic/DOC family; Region: Fic; pfam02661 698964006565 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 698964006566 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 698964006567 E-class dimer interface [polypeptide binding]; other site 698964006568 P-class dimer interface [polypeptide binding]; other site 698964006569 active site 698964006570 Cu2+ binding site [ion binding]; other site 698964006571 Zn2+ binding site [ion binding]; other site 698964006572 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 698964006573 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698964006574 active site 698964006575 HIGH motif; other site 698964006576 nucleotide binding site [chemical binding]; other site 698964006577 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 698964006578 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698964006579 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698964006580 active site 698964006581 KMSKS motif; other site 698964006582 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 698964006583 tRNA binding surface [nucleotide binding]; other site 698964006584 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698964006585 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698964006586 Walker A/P-loop; other site 698964006587 ATP binding site [chemical binding]; other site 698964006588 Q-loop/lid; other site 698964006589 ABC transporter signature motif; other site 698964006590 Walker B; other site 698964006591 D-loop; other site 698964006592 H-loop/switch region; other site 698964006593 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698964006594 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698964006595 Histidine kinase; Region: HisKA_3; pfam07730 698964006596 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 698964006597 ATP binding site [chemical binding]; other site 698964006598 G-X-G motif; other site 698964006599 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698964006600 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698964006601 active site 698964006602 phosphorylation site [posttranslational modification] 698964006603 intermolecular recognition site; other site 698964006604 dimerization interface [polypeptide binding]; other site 698964006605 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698964006606 DNA binding residues [nucleotide binding] 698964006607 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 698964006608 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 698964006609 Predicted membrane protein [Function unknown]; Region: COG1511 698964006610 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698964006611 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698964006612 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698964006613 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 698964006614 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 698964006615 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698964006616 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 698964006617 NAD(P) binding site [chemical binding]; other site 698964006618 catalytic residues [active] 698964006619 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 698964006620 active site 698964006621 phosphorylation site [posttranslational modification] 698964006622 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 698964006623 active site 698964006624 P-loop; other site 698964006625 phosphorylation site [posttranslational modification] 698964006626 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 698964006627 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 698964006628 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 698964006629 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 698964006630 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 698964006631 active site 698964006632 active pocket/dimerization site; other site 698964006633 phosphorylation site [posttranslational modification] 698964006634 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 698964006635 dimerization domain swap beta strand [polypeptide binding]; other site 698964006636 regulatory protein interface [polypeptide binding]; other site 698964006637 active site 698964006638 regulatory phosphorylation site [posttranslational modification]; other site 698964006639 Predicted ATPases [General function prediction only]; Region: COG1106 698964006640 Putative esterase; Region: Esterase; pfam00756 698964006641 S-formylglutathione hydrolase; Region: PLN02442 698964006642 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 698964006643 active site 698964006644 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 698964006645 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698964006646 ABC transporter signature motif; other site 698964006647 Walker B; other site 698964006648 D-loop; other site 698964006649 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 698964006650 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698964006651 Walker A/P-loop; other site 698964006652 ATP binding site [chemical binding]; other site 698964006653 Q-loop/lid; other site 698964006654 ABC transporter signature motif; other site 698964006655 Walker B; other site 698964006656 D-loop; other site 698964006657 H-loop/switch region; other site 698964006658 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 698964006659 active site 698964006660 catalytic residues [active] 698964006661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 698964006662 hypothetical protein; Provisional; Region: PRK13663 698964006663 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698964006664 putative active site [active] 698964006665 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 698964006666 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 698964006667 SdpI/YhfL protein family; Region: SdpI; pfam13630 698964006668 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 698964006669 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 698964006670 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698964006671 catalytic residue [active] 698964006672 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698964006673 Helix-turn-helix domain; Region: HTH_38; pfam13936 698964006674 Integrase core domain; Region: rve; pfam00665 698964006675 anthranilate synthase component I; Provisional; Region: PRK13564 698964006676 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 698964006677 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698964006678 Glutamine amidotransferase class-I; Region: GATase; pfam00117 698964006679 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 698964006680 glutamine binding [chemical binding]; other site 698964006681 catalytic triad [active] 698964006682 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 698964006683 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 698964006684 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 698964006685 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 698964006686 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 698964006687 active site 698964006688 ribulose/triose binding site [chemical binding]; other site 698964006689 phosphate binding site [ion binding]; other site 698964006690 substrate (anthranilate) binding pocket [chemical binding]; other site 698964006691 product (indole) binding pocket [chemical binding]; other site 698964006692 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 698964006693 active site 698964006694 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 698964006695 pantoate--beta-alanine ligase; Region: panC; TIGR00018 698964006696 Pantoate-beta-alanine ligase; Region: PanC; cd00560 698964006697 active site 698964006698 ATP-binding site [chemical binding]; other site 698964006699 pantoate-binding site; other site 698964006700 HXXH motif; other site 698964006701 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 698964006702 oligomerization interface [polypeptide binding]; other site 698964006703 active site 698964006704 metal binding site [ion binding]; metal-binding site 698964006705 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 698964006706 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 698964006707 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698964006708 catalytic residue [active] 698964006709 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 698964006710 substrate binding site [chemical binding]; other site 698964006711 active site 698964006712 catalytic residues [active] 698964006713 heterodimer interface [polypeptide binding]; other site 698964006714 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 698964006715 iron-sulfur cluster [ion binding]; other site 698964006716 [2Fe-2S] cluster binding site [ion binding]; other site 698964006717 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 698964006718 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 698964006719 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 698964006720 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 698964006721 hypothetical protein; Validated; Region: PRK00228 698964006722 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 698964006723 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 698964006724 active site 698964006725 NTP binding site [chemical binding]; other site 698964006726 metal binding triad [ion binding]; metal-binding site 698964006727 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 698964006728 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698964006729 Zn2+ binding site [ion binding]; other site 698964006730 Mg2+ binding site [ion binding]; other site 698964006731 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 698964006732 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 698964006733 active site 698964006734 Ap6A binding site [chemical binding]; other site 698964006735 nudix motif; other site 698964006736 metal binding site [ion binding]; metal-binding site 698964006737 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 698964006738 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 698964006739 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 698964006740 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698964006741 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698964006742 DNA binding residues [nucleotide binding] 698964006743 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 698964006744 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698964006745 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698964006746 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698964006747 catalytic residues [active] 698964006748 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698964006749 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698964006750 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 698964006751 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 698964006752 active site 698964006753 metal binding site [ion binding]; metal-binding site 698964006754 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 698964006755 ParB-like nuclease domain; Region: ParBc; pfam02195 698964006756 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 698964006757 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698964006758 P-loop; other site 698964006759 Magnesium ion binding site [ion binding]; other site 698964006760 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698964006761 Magnesium ion binding site [ion binding]; other site 698964006762 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 698964006763 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 698964006764 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 698964006765 Haemolytic domain; Region: Haemolytic; pfam01809 698964006766 ribonuclease P; Reviewed; Region: rnpA; PRK03459 698964006767 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399