-- dump date 20140619_051253 -- class Genbank::misc_feature -- table misc_feature_note -- id note 698971000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 698971000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698971000003 Walker A motif; other site 698971000004 ATP binding site [chemical binding]; other site 698971000005 Walker B motif; other site 698971000006 arginine finger; other site 698971000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 698971000008 DnaA box-binding interface [nucleotide binding]; other site 698971000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 698971000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 698971000011 putative DNA binding surface [nucleotide binding]; other site 698971000012 dimer interface [polypeptide binding]; other site 698971000013 beta-clamp/clamp loader binding surface; other site 698971000014 beta-clamp/translesion DNA polymerase binding surface; other site 698971000015 recombination protein F; Reviewed; Region: recF; PRK00064 698971000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 698971000017 Walker A/P-loop; other site 698971000018 ATP binding site [chemical binding]; other site 698971000019 Q-loop/lid; other site 698971000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698971000021 ABC transporter signature motif; other site 698971000022 Walker B; other site 698971000023 D-loop; other site 698971000024 H-loop/switch region; other site 698971000025 hypothetical protein; Provisional; Region: PRK00111 698971000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 698971000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698971000028 ATP binding site [chemical binding]; other site 698971000029 Mg2+ binding site [ion binding]; other site 698971000030 G-X-G motif; other site 698971000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 698971000032 anchoring element; other site 698971000033 dimer interface [polypeptide binding]; other site 698971000034 ATP binding site [chemical binding]; other site 698971000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 698971000036 active site 698971000037 putative metal-binding site [ion binding]; other site 698971000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 698971000039 DNA gyrase subunit A; Validated; Region: PRK05560 698971000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 698971000041 CAP-like domain; other site 698971000042 active site 698971000043 primary dimer interface [polypeptide binding]; other site 698971000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698971000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698971000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698971000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698971000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698971000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698971000050 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 698971000051 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698971000052 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698971000053 DNA-binding site [nucleotide binding]; DNA binding site 698971000054 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 698971000055 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 698971000056 L-lactate permease; Region: Lactate_perm; cl00701 698971000057 Cadherin repeat-like domain; Region: CA_like; cl15786 698971000058 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698971000059 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698971000060 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 698971000061 Walker A/P-loop; other site 698971000062 ATP binding site [chemical binding]; other site 698971000063 Q-loop/lid; other site 698971000064 ABC transporter signature motif; other site 698971000065 Walker B; other site 698971000066 D-loop; other site 698971000067 H-loop/switch region; other site 698971000068 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698971000069 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 698971000070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698971000071 Walker A/P-loop; other site 698971000072 ATP binding site [chemical binding]; other site 698971000073 Q-loop/lid; other site 698971000074 ABC transporter signature motif; other site 698971000075 Walker B; other site 698971000076 D-loop; other site 698971000077 H-loop/switch region; other site 698971000078 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 698971000079 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698971000080 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 698971000081 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698971000082 putative ligand binding site [chemical binding]; other site 698971000083 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698971000084 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698971000085 TM-ABC transporter signature motif; other site 698971000086 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698971000087 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698971000088 Walker A/P-loop; other site 698971000089 ATP binding site [chemical binding]; other site 698971000090 Q-loop/lid; other site 698971000091 ABC transporter signature motif; other site 698971000092 Walker B; other site 698971000093 D-loop; other site 698971000094 H-loop/switch region; other site 698971000095 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 698971000096 active site 698971000097 Integrase core domain; Region: rve_2; pfam13333 698971000098 Rhomboid family; Region: Rhomboid; pfam01694 698971000099 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 698971000100 ThiC-associated domain; Region: ThiC-associated; pfam13667 698971000101 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 698971000102 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 698971000103 thiamine phosphate binding site [chemical binding]; other site 698971000104 active site 698971000105 pyrophosphate binding site [ion binding]; other site 698971000106 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698971000107 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 698971000108 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 698971000109 ThiS interaction site; other site 698971000110 putative active site [active] 698971000111 tetramer interface [polypeptide binding]; other site 698971000112 thiamine biosynthesis protein ThiF; Validated; Region: PRK05600 698971000113 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 698971000114 ATP binding site [chemical binding]; other site 698971000115 substrate interface [chemical binding]; other site 698971000116 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698971000117 active site residue [active] 698971000118 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 698971000119 dimer interface [polypeptide binding]; other site 698971000120 substrate binding site [chemical binding]; other site 698971000121 ATP binding site [chemical binding]; other site 698971000122 CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865 698971000123 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 698971000124 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 698971000125 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 698971000126 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442 698971000127 potential frameshift: common BLAST hit: gi|336326698|ref|YP_004606664.1| transposase for insertion sequence element 698971000128 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698971000129 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698971000130 MULE transposase domain; Region: MULE; pfam10551 698971000131 putative septation inhibitor protein; Reviewed; Region: PRK00159 698971000132 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 698971000133 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698971000134 active site 698971000135 ATP binding site [chemical binding]; other site 698971000136 substrate binding site [chemical binding]; other site 698971000137 activation loop (A-loop); other site 698971000138 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 698971000139 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698971000140 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698971000141 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698971000142 PASTA domain; Region: PASTA; pfam03793 698971000143 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698971000144 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698971000145 active site 698971000146 ATP binding site [chemical binding]; other site 698971000147 substrate binding site [chemical binding]; other site 698971000148 activation loop (A-loop); other site 698971000149 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 698971000150 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 698971000151 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698971000152 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 698971000153 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 698971000154 Protein phosphatase 2C; Region: PP2C; pfam00481 698971000155 active site 698971000156 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 698971000157 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 698971000158 phosphopeptide binding site; other site 698971000159 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 698971000160 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 698971000161 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 698971000162 phosphopeptide binding site; other site 698971000163 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698971000164 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698971000165 non-specific DNA binding site [nucleotide binding]; other site 698971000166 salt bridge; other site 698971000167 sequence-specific DNA binding site [nucleotide binding]; other site 698971000168 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 698971000169 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 698971000170 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 698971000171 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 698971000172 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 698971000173 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 698971000174 Walker A/P-loop; other site 698971000175 ATP binding site [chemical binding]; other site 698971000176 Q-loop/lid; other site 698971000177 ABC transporter signature motif; other site 698971000178 Walker B; other site 698971000179 D-loop; other site 698971000180 H-loop/switch region; other site 698971000181 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698971000182 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698971000183 active site 698971000184 phosphorylation site [posttranslational modification] 698971000185 intermolecular recognition site; other site 698971000186 dimerization interface [polypeptide binding]; other site 698971000187 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698971000188 DNA binding residues [nucleotide binding] 698971000189 dimerization interface [polypeptide binding]; other site 698971000190 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698971000191 Histidine kinase; Region: HisKA_3; pfam07730 698971000192 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 698971000193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698971000194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698971000195 dimer interface [polypeptide binding]; other site 698971000196 conserved gate region; other site 698971000197 putative PBP binding loops; other site 698971000198 ABC-ATPase subunit interface; other site 698971000199 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698971000200 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 698971000201 Walker A/P-loop; other site 698971000202 ATP binding site [chemical binding]; other site 698971000203 Q-loop/lid; other site 698971000204 ABC transporter signature motif; other site 698971000205 Walker B; other site 698971000206 D-loop; other site 698971000207 H-loop/switch region; other site 698971000208 Anti-sigma-K factor rskA; Region: RskA; pfam10099 698971000209 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 698971000210 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698971000211 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698971000212 DNA binding residues [nucleotide binding] 698971000213 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 698971000214 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 698971000215 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 698971000216 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698971000217 catalytic residues [active] 698971000218 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 698971000219 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698971000220 DNA binding residues [nucleotide binding] 698971000221 dimer interface [polypeptide binding]; other site 698971000222 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 698971000223 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 698971000224 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 698971000225 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 698971000226 putative metal binding site [ion binding]; other site 698971000227 biotin synthase; Validated; Region: PRK06256 698971000228 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698971000229 FeS/SAM binding site; other site 698971000230 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 698971000231 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 698971000232 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 698971000233 putative ligand binding residues [chemical binding]; other site 698971000234 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698971000235 ABC-ATPase subunit interface; other site 698971000236 dimer interface [polypeptide binding]; other site 698971000237 putative PBP binding regions; other site 698971000238 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698971000239 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698971000240 Walker A/P-loop; other site 698971000241 ATP binding site [chemical binding]; other site 698971000242 Q-loop/lid; other site 698971000243 ABC transporter signature motif; other site 698971000244 Walker B; other site 698971000245 D-loop; other site 698971000246 H-loop/switch region; other site 698971000247 Uncharacterized conserved protein [Function unknown]; Region: COG5646 698971000248 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 698971000249 DNA photolyase; Region: DNA_photolyase; pfam00875 698971000250 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 698971000251 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 698971000252 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 698971000253 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 698971000254 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 698971000255 Lipase (class 2); Region: Lipase_2; pfam01674 698971000256 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370 698971000257 dimer interface [polypeptide binding]; other site 698971000258 FMN binding site [chemical binding]; other site 698971000259 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698971000260 Divergent AAA domain; Region: AAA_4; pfam04326 698971000261 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698971000262 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698971000263 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 698971000264 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 698971000265 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 698971000266 trimer interface [polypeptide binding]; other site 698971000267 putative metal binding site [ion binding]; other site 698971000268 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698971000269 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 698971000270 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 698971000271 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 698971000272 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698971000273 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 698971000274 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805 698971000275 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698971000276 MarR family; Region: MarR; pfam01047 698971000277 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 698971000278 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 698971000279 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 698971000280 hypothetical protein; Provisional; Region: PRK10621 698971000281 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 698971000282 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 698971000283 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698971000284 ATP binding site [chemical binding]; other site 698971000285 putative Mg++ binding site [ion binding]; other site 698971000286 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698971000287 nucleotide binding region [chemical binding]; other site 698971000288 Helicase associated domain (HA2); Region: HA2; pfam04408 698971000289 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 698971000290 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698971000291 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 698971000292 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 698971000293 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 698971000294 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698971000295 NAD(P) binding site [chemical binding]; other site 698971000296 active site 698971000297 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698971000298 potential frameshift: common BLAST hit: gi|336325819|ref|YP_004605785.1| transposase for insertion sequence element 698971000299 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698971000300 Integrase core domain; Region: rve; pfam00665 698971000301 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 698971000302 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698971000303 RNA binding surface [nucleotide binding]; other site 698971000304 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 698971000305 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698971000306 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 698971000307 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 698971000308 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 698971000309 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 698971000310 active site 698971000311 Zn binding site [ion binding]; other site 698971000312 Protease prsW family; Region: PrsW-protease; pfam13367 698971000313 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 698971000314 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 698971000315 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 698971000316 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 698971000317 short chain dehydrogenase; Provisional; Region: PRK07904 698971000318 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698971000319 NAD(P) binding site [chemical binding]; other site 698971000320 active site 698971000321 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 698971000322 FAD binding domain; Region: FAD_binding_4; pfam01565 698971000323 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 698971000324 Predicted membrane protein [Function unknown]; Region: COG2246 698971000325 GtrA-like protein; Region: GtrA; pfam04138 698971000326 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 698971000327 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698971000328 active site 698971000329 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698971000330 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698971000331 intersubunit interface [polypeptide binding]; other site 698971000332 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698971000333 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698971000334 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698971000335 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698971000336 ABC-ATPase subunit interface; other site 698971000337 dimer interface [polypeptide binding]; other site 698971000338 putative PBP binding regions; other site 698971000339 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698971000340 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698971000341 ABC-ATPase subunit interface; other site 698971000342 dimer interface [polypeptide binding]; other site 698971000343 putative PBP binding regions; other site 698971000344 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698971000345 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698971000346 intersubunit interface [polypeptide binding]; other site 698971000347 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 698971000348 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 698971000349 Walker A/P-loop; other site 698971000350 ATP binding site [chemical binding]; other site 698971000351 Q-loop/lid; other site 698971000352 ABC transporter signature motif; other site 698971000353 Walker B; other site 698971000354 D-loop; other site 698971000355 H-loop/switch region; other site 698971000356 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 698971000357 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 698971000358 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 698971000359 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698971000360 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698971000361 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 698971000362 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 698971000363 NAD(P) binding site [chemical binding]; other site 698971000364 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 698971000365 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698971000366 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698971000367 homodimer interface [polypeptide binding]; other site 698971000368 catalytic residue [active] 698971000369 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 698971000370 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 698971000371 transmembrane helices; other site 698971000372 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 698971000373 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 698971000374 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 698971000375 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698971000376 DNA-binding site [nucleotide binding]; DNA binding site 698971000377 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698971000378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698971000379 homodimer interface [polypeptide binding]; other site 698971000380 catalytic residue [active] 698971000381 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 698971000382 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 698971000383 active site 698971000384 multimer interface [polypeptide binding]; other site 698971000385 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 698971000386 predicted active site [active] 698971000387 catalytic triad [active] 698971000388 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698971000389 active site 698971000390 catalytic site [active] 698971000391 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 698971000392 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698971000393 active site 698971000394 catalytic site [active] 698971000395 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 698971000396 metal coordination site [ion binding]; other site 698971000397 Cna protein B-type domain; Region: Cna_B; pfam05738 698971000398 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698971000399 metal ion-dependent adhesion site (MIDAS); other site 698971000400 Cna protein B-type domain; Region: Cna_B; pfam05738 698971000401 Transposase; Region: HTH_Tnp_1; cl17663 698971000402 Ribosome inactivating protein; Region: RIP; pfam00161 698971000403 prephenate dehydrogenase; Validated; Region: PRK06545 698971000404 prephenate dehydrogenase; Validated; Region: PRK08507 698971000405 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 698971000406 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 698971000407 nucleoside/Zn binding site; other site 698971000408 dimer interface [polypeptide binding]; other site 698971000409 catalytic motif [active] 698971000410 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 698971000411 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 698971000412 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 698971000413 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 698971000414 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 698971000415 active site 698971000416 HIGH motif; other site 698971000417 nucleotide binding site [chemical binding]; other site 698971000418 active site 698971000419 KMSKS motif; other site 698971000420 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 698971000421 fructuronate transporter; Provisional; Region: PRK10034; cl15264 698971000422 Shikimate kinase; Region: SKI; pfam01202 698971000423 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 698971000424 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 698971000425 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 698971000426 putative NAD(P) binding site [chemical binding]; other site 698971000427 catalytic Zn binding site [ion binding]; other site 698971000428 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 698971000429 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 698971000430 NADP binding site [chemical binding]; other site 698971000431 homodimer interface [polypeptide binding]; other site 698971000432 active site 698971000433 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 698971000434 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698971000435 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698971000436 homodimer interface [polypeptide binding]; other site 698971000437 catalytic residue [active] 698971000438 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 698971000439 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 698971000440 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698971000441 Walker A motif; other site 698971000442 ATP binding site [chemical binding]; other site 698971000443 Walker B motif; other site 698971000444 arginine finger; other site 698971000445 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 698971000446 hypothetical protein; Validated; Region: PRK00153 698971000447 recombination protein RecR; Reviewed; Region: recR; PRK00076 698971000448 RecR protein; Region: RecR; pfam02132 698971000449 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 698971000450 putative active site [active] 698971000451 putative metal-binding site [ion binding]; other site 698971000452 tetramer interface [polypeptide binding]; other site 698971000453 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 698971000454 catalytic triad [active] 698971000455 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 698971000456 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698971000457 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 698971000458 DNA polymerase III subunit epsilon; Validated; Region: PRK05601 698971000459 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698971000460 active site 698971000461 catalytic site [active] 698971000462 substrate binding site [chemical binding]; other site 698971000463 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 698971000464 dimer interface [polypeptide binding]; other site 698971000465 FMN binding site [chemical binding]; other site 698971000466 NADPH bind site [chemical binding]; other site 698971000467 2-isopropylmalate synthase; Validated; Region: PRK03739 698971000468 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 698971000469 active site 698971000470 catalytic residues [active] 698971000471 metal binding site [ion binding]; metal-binding site 698971000472 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 698971000473 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 698971000474 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698971000475 DNA binding residues [nucleotide binding] 698971000476 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 698971000477 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698971000478 active site 698971000479 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 698971000480 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698971000481 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698971000482 putative substrate translocation pore; other site 698971000483 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 698971000484 intersubunit interface [polypeptide binding]; other site 698971000485 active site 698971000486 catalytic residue [active] 698971000487 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 698971000488 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 698971000489 active site 698971000490 substrate binding site [chemical binding]; other site 698971000491 metal binding site [ion binding]; metal-binding site 698971000492 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188 698971000493 aspartate kinase; Reviewed; Region: PRK06635 698971000494 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 698971000495 putative nucleotide binding site [chemical binding]; other site 698971000496 putative catalytic residues [active] 698971000497 putative Mg ion binding site [ion binding]; other site 698971000498 putative aspartate binding site [chemical binding]; other site 698971000499 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 698971000500 putative allosteric regulatory site; other site 698971000501 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 698971000502 putative allosteric regulatory residue; other site 698971000503 potential frameshift: common BLAST hit: gi|38232899|ref|NP_938666.1| surface-anchored membrane protein 698971000504 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 698971000505 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 698971000506 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 698971000507 RNA polymerase sigma factor; Provisional; Region: PRK12535 698971000508 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698971000509 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 698971000510 DNA binding residues [nucleotide binding] 698971000511 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 698971000512 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 698971000513 heme binding pocket [chemical binding]; other site 698971000514 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698971000515 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 698971000516 Walker A/P-loop; other site 698971000517 ATP binding site [chemical binding]; other site 698971000518 Q-loop/lid; other site 698971000519 ABC transporter signature motif; other site 698971000520 Walker B; other site 698971000521 D-loop; other site 698971000522 H-loop/switch region; other site 698971000523 TOBE domain; Region: TOBE_2; pfam08402 698971000524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698971000525 dimer interface [polypeptide binding]; other site 698971000526 conserved gate region; other site 698971000527 ABC-ATPase subunit interface; other site 698971000528 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 698971000529 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 698971000530 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698971000531 putative substrate translocation pore; other site 698971000532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698971000533 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698971000534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698971000535 active site 698971000536 phosphorylation site [posttranslational modification] 698971000537 intermolecular recognition site; other site 698971000538 dimerization interface [polypeptide binding]; other site 698971000539 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698971000540 DNA binding site [nucleotide binding] 698971000541 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698971000542 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698971000543 dimer interface [polypeptide binding]; other site 698971000544 phosphorylation site [posttranslational modification] 698971000545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698971000546 ATP binding site [chemical binding]; other site 698971000547 Mg2+ binding site [ion binding]; other site 698971000548 G-X-G motif; other site 698971000549 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 698971000550 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612 698971000551 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654 698971000552 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 698971000553 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698971000554 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 698971000555 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 698971000556 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698971000557 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 698971000558 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 698971000559 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 698971000560 Predicted membrane protein [Function unknown]; Region: COG1511 698971000561 Predicted membrane protein [Function unknown]; Region: COG1511 698971000562 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 698971000563 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698971000564 putative active site [active] 698971000565 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 698971000566 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698971000567 putative active site [active] 698971000568 putative metal binding site [ion binding]; other site 698971000569 Yqey-like protein; Region: YqeY; pfam09424 698971000570 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 698971000571 Transglycosylase; Region: Transgly; pfam00912 698971000572 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 698971000573 PASTA domain; Region: PASTA; pfam03793 698971000574 Transcription factor WhiB; Region: Whib; pfam02467 698971000575 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 698971000576 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 698971000577 homotrimer interaction site [polypeptide binding]; other site 698971000578 putative active site [active] 698971000579 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698971000580 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 698971000581 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698971000582 ligand binding site [chemical binding]; other site 698971000583 flexible hinge region; other site 698971000584 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 698971000585 putative switch regulator; other site 698971000586 non-specific DNA interactions [nucleotide binding]; other site 698971000587 DNA binding site [nucleotide binding] 698971000588 sequence specific DNA binding site [nucleotide binding]; other site 698971000589 putative cAMP binding site [chemical binding]; other site 698971000590 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 698971000591 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698971000592 minor groove reading motif; other site 698971000593 helix-hairpin-helix signature motif; other site 698971000594 substrate binding pocket [chemical binding]; other site 698971000595 active site 698971000596 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 698971000597 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 698971000598 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698971000599 catalytic residues [active] 698971000600 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 698971000601 putative active site [active] 698971000602 putative CoA binding site [chemical binding]; other site 698971000603 nudix motif; other site 698971000604 metal binding site [ion binding]; metal-binding site 698971000605 Colicin V production protein; Region: Colicin_V; pfam02674 698971000606 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 698971000607 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 698971000608 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698971000609 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698971000610 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 698971000611 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 698971000612 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698971000613 motif II; other site 698971000614 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 698971000615 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 698971000616 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 698971000617 ATP binding site [chemical binding]; other site 698971000618 Walker A motif; other site 698971000619 hexamer interface [polypeptide binding]; other site 698971000620 Walker B motif; other site 698971000621 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 698971000622 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 698971000623 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 698971000624 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698971000625 ATP binding site [chemical binding]; other site 698971000626 putative Mg++ binding site [ion binding]; other site 698971000627 nucleotide binding region [chemical binding]; other site 698971000628 helicase superfamily c-terminal domain; Region: HELICc; smart00490 698971000629 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 698971000630 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698971000631 DNA-binding site [nucleotide binding]; DNA binding site 698971000632 RNA-binding motif; other site 698971000633 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698971000634 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698971000635 Walker A/P-loop; other site 698971000636 ATP binding site [chemical binding]; other site 698971000637 Q-loop/lid; other site 698971000638 ABC transporter signature motif; other site 698971000639 Walker B; other site 698971000640 D-loop; other site 698971000641 H-loop/switch region; other site 698971000642 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698971000643 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 698971000644 Walker A/P-loop; other site 698971000645 ATP binding site [chemical binding]; other site 698971000646 Q-loop/lid; other site 698971000647 ABC transporter signature motif; other site 698971000648 Walker B; other site 698971000649 D-loop; other site 698971000650 H-loop/switch region; other site 698971000651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698971000652 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698971000653 putative substrate translocation pore; other site 698971000654 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698971000655 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 698971000656 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698971000657 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 698971000658 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698971000659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698971000660 dimer interface [polypeptide binding]; other site 698971000661 conserved gate region; other site 698971000662 putative PBP binding loops; other site 698971000663 ABC-ATPase subunit interface; other site 698971000664 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 698971000665 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698971000666 NAD(P) binding site [chemical binding]; other site 698971000667 active site 698971000668 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 698971000669 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 698971000670 DNA topoisomerase I, bacterial; Region: topA_bact; TIGR01051 698971000671 active site 698971000672 interdomain interaction site; other site 698971000673 putative metal-binding site [ion binding]; other site 698971000674 nucleotide binding site [chemical binding]; other site 698971000675 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 698971000676 domain I; other site 698971000677 DNA binding groove [nucleotide binding] 698971000678 phosphate binding site [ion binding]; other site 698971000679 domain II; other site 698971000680 domain III; other site 698971000681 nucleotide binding site [chemical binding]; other site 698971000682 catalytic site [active] 698971000683 domain IV; other site 698971000684 Uncharacterized C-terminal domain of topoisomerase IA [General function prediction only]; Region: COG1754 698971000685 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 698971000686 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 698971000687 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 698971000688 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 698971000689 active site 698971000690 Predicted membrane protein [Function unknown]; Region: COG1297 698971000691 putative oligopeptide transporter, OPT family; Region: TIGR00733 698971000692 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 698971000693 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 698971000694 catalytic site [active] 698971000695 Asp-box motif; other site 698971000696 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698971000697 dimerization interface [polypeptide binding]; other site 698971000698 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698971000699 cyclase homology domain; Region: CHD; cd07302 698971000700 nucleotidyl binding site; other site 698971000701 metal binding site [ion binding]; metal-binding site 698971000702 dimer interface [polypeptide binding]; other site 698971000703 DNA polymerase III subunit delta'; Validated; Region: PRK07940 698971000704 DNA polymerase III subunit delta'; Validated; Region: PRK08485 698971000705 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 698971000706 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698971000707 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 698971000708 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 698971000709 DNA binding site [nucleotide binding] 698971000710 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 698971000711 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 698971000712 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698971000713 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 698971000714 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 698971000715 Fic family protein [Function unknown]; Region: COG3177 698971000716 Fic/DOC family; Region: Fic; pfam02661 698971000717 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 698971000718 Trypsin; Region: Trypsin; pfam00089 698971000719 active site 698971000720 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 698971000721 putative DNA binding site [nucleotide binding]; other site 698971000722 putative Zn2+ binding site [ion binding]; other site 698971000723 potential frameshift: common BLAST hit: gi|227832949|ref|YP_002834656.1| transposase 698971000724 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698971000725 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698971000726 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698971000727 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 698971000728 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698971000729 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 698971000730 active site 698971000731 catalytic site [active] 698971000732 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 698971000733 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 698971000734 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 698971000735 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 698971000736 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 698971000737 Ca binding site [ion binding]; other site 698971000738 active site 698971000739 catalytic site [active] 698971000740 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 698971000741 acyl-CoA synthetase; Validated; Region: PRK07788 698971000742 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698971000743 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698971000744 acyl-activating enzyme (AAE) consensus motif; other site 698971000745 acyl-activating enzyme (AAE) consensus motif; other site 698971000746 AMP binding site [chemical binding]; other site 698971000747 active site 698971000748 CoA binding site [chemical binding]; other site 698971000749 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 698971000750 active site 698971000751 catalytic triad [active] 698971000752 oxyanion hole [active] 698971000753 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 698971000754 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 698971000755 substrate binding site; other site 698971000756 tetramer interface; other site 698971000757 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 698971000758 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 698971000759 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 698971000760 NADP binding site [chemical binding]; other site 698971000761 active site 698971000762 putative substrate binding site [chemical binding]; other site 698971000763 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 698971000764 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 698971000765 NAD binding site [chemical binding]; other site 698971000766 substrate binding site [chemical binding]; other site 698971000767 homodimer interface [polypeptide binding]; other site 698971000768 active site 698971000769 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 698971000770 Zn binding site [ion binding]; other site 698971000771 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 698971000772 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698971000773 Putative esterase; Region: Esterase; pfam00756 698971000774 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 698971000775 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 698971000776 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698971000777 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698971000778 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698971000779 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698971000780 non-specific DNA binding site [nucleotide binding]; other site 698971000781 salt bridge; other site 698971000782 sequence-specific DNA binding site [nucleotide binding]; other site 698971000783 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 698971000784 Domain of unknown function (DUF955); Region: DUF955; pfam06114 698971000785 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 698971000786 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 698971000787 putative Iron-sulfur protein interface [polypeptide binding]; other site 698971000788 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 698971000789 proximal heme binding site [chemical binding]; other site 698971000790 distal heme binding site [chemical binding]; other site 698971000791 putative dimer interface [polypeptide binding]; other site 698971000792 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 698971000793 L-aspartate oxidase; Provisional; Region: PRK06175 698971000794 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 698971000795 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 698971000796 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 698971000797 Predicted membrane protein [Function unknown]; Region: COG2733 698971000798 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 698971000799 Class I aldolases; Region: Aldolase_Class_I; cl17187 698971000800 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 698971000801 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 698971000802 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698971000803 FeS/SAM binding site; other site 698971000804 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 698971000805 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 698971000806 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 698971000807 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698971000808 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 698971000809 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 698971000810 FAD binding domain; Region: FAD_binding_4; pfam01565 698971000811 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 698971000812 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 698971000813 pentamer interface [polypeptide binding]; other site 698971000814 dodecaamer interface [polypeptide binding]; other site 698971000815 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 698971000816 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698971000817 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698971000818 acyl-activating enzyme (AAE) consensus motif; other site 698971000819 AMP binding site [chemical binding]; other site 698971000820 active site 698971000821 CoA binding site [chemical binding]; other site 698971000822 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 698971000823 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 698971000824 acyl-activating enzyme (AAE) consensus motif; other site 698971000825 putative AMP binding site [chemical binding]; other site 698971000826 putative active site [active] 698971000827 putative CoA binding site [chemical binding]; other site 698971000828 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 698971000829 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 698971000830 putative ADP-binding pocket [chemical binding]; other site 698971000831 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698971000832 catalytic core [active] 698971000833 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698971000834 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 698971000835 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698971000836 dimer interface [polypeptide binding]; other site 698971000837 phosphorylation site [posttranslational modification] 698971000838 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698971000839 ATP binding site [chemical binding]; other site 698971000840 Mg2+ binding site [ion binding]; other site 698971000841 G-X-G motif; other site 698971000842 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698971000843 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698971000844 active site 698971000845 phosphorylation site [posttranslational modification] 698971000846 intermolecular recognition site; other site 698971000847 dimerization interface [polypeptide binding]; other site 698971000848 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698971000849 DNA binding site [nucleotide binding] 698971000850 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 698971000851 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 698971000852 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 698971000853 DNA binding domain, excisionase family; Region: excise; TIGR01764 698971000854 Thioredoxin; Region: Thioredoxin_4; cl17273 698971000855 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 698971000856 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 698971000857 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 698971000858 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698971000859 motif II; other site 698971000860 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 698971000861 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 698971000862 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 698971000863 tRNA; other site 698971000864 putative tRNA binding site [nucleotide binding]; other site 698971000865 putative NADP binding site [chemical binding]; other site 698971000866 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 698971000867 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 698971000868 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 698971000869 domain interfaces; other site 698971000870 active site 698971000871 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 698971000872 active site 698971000873 homodimer interface [polypeptide binding]; other site 698971000874 SAM binding site [chemical binding]; other site 698971000875 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 698971000876 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 698971000877 active site 698971000878 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 698971000879 dimer interface [polypeptide binding]; other site 698971000880 active site 698971000881 Schiff base residues; other site 698971000882 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 698971000883 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698971000884 Predicted membrane protein [Function unknown]; Region: COG2311 698971000885 Protein of unknown function (DUF418); Region: DUF418; pfam04235 698971000886 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 698971000887 substrate binding site [chemical binding]; other site 698971000888 active site 698971000889 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 698971000890 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 698971000891 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698971000892 inhibitor-cofactor binding pocket; inhibition site 698971000893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698971000894 catalytic residue [active] 698971000895 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698971000896 catalytic core [active] 698971000897 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 698971000898 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698971000899 catalytic residues [active] 698971000900 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 698971000901 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 698971000902 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 698971000903 ResB-like family; Region: ResB; pfam05140 698971000904 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 698971000905 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 698971000906 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 698971000907 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 698971000908 UbiA prenyltransferase family; Region: UbiA; pfam01040 698971000909 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698971000910 active site 698971000911 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698971000912 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 698971000913 acyl-activating enzyme (AAE) consensus motif; other site 698971000914 AMP binding site [chemical binding]; other site 698971000915 active site 698971000916 CoA binding site [chemical binding]; other site 698971000917 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 698971000918 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698971000919 substrate binding site [chemical binding]; other site 698971000920 oxyanion hole (OAH) forming residues; other site 698971000921 trimer interface [polypeptide binding]; other site 698971000922 O-succinylbenzoate synthase; Provisional; Region: PRK02901 698971000923 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 698971000924 active site 698971000925 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 698971000926 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 698971000927 dimer interface [polypeptide binding]; other site 698971000928 tetramer interface [polypeptide binding]; other site 698971000929 PYR/PP interface [polypeptide binding]; other site 698971000930 TPP binding site [chemical binding]; other site 698971000931 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 698971000932 TPP-binding site; other site 698971000933 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 698971000934 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698971000935 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 698971000936 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 698971000937 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698971000938 S-adenosylmethionine binding site [chemical binding]; other site 698971000939 A subgroup of L-lactate dehydrogenases; Region: LDH_3; cd05290 698971000940 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 698971000941 NAD binding site [chemical binding]; other site 698971000942 dimer interface [polypeptide binding]; other site 698971000943 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698971000944 substrate binding site [chemical binding]; other site 698971000945 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 698971000946 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 698971000947 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 698971000948 substrate binding pocket [chemical binding]; other site 698971000949 chain length determination region; other site 698971000950 substrate-Mg2+ binding site; other site 698971000951 catalytic residues [active] 698971000952 aspartate-rich region 1; other site 698971000953 active site lid residues [active] 698971000954 aspartate-rich region 2; other site 698971000955 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 698971000956 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 698971000957 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 698971000958 putative homodimer interface [polypeptide binding]; other site 698971000959 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 698971000960 heterodimer interface [polypeptide binding]; other site 698971000961 homodimer interface [polypeptide binding]; other site 698971000962 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 698971000963 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 698971000964 23S rRNA interface [nucleotide binding]; other site 698971000965 L7/L12 interface [polypeptide binding]; other site 698971000966 putative thiostrepton binding site; other site 698971000967 L25 interface [polypeptide binding]; other site 698971000968 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 698971000969 mRNA/rRNA interface [nucleotide binding]; other site 698971000970 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 698971000971 23S rRNA interface [nucleotide binding]; other site 698971000972 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 698971000973 50S ribosomal protein L7/L12; Reviewed; Region: rplL; PRK00157 698971000974 L11 interface [polypeptide binding]; other site 698971000975 putative EF-Tu interaction site [polypeptide binding]; other site 698971000976 putative EF-G interaction site [polypeptide binding]; other site 698971000977 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 698971000978 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698971000979 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698971000980 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698971000981 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698971000982 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698971000983 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 698971000984 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698971000985 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698971000986 ABC-ATPase subunit interface; other site 698971000987 dimer interface [polypeptide binding]; other site 698971000988 putative PBP binding regions; other site 698971000989 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 698971000990 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698971000991 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698971000992 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 698971000993 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 698971000994 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 698971000995 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 698971000996 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 698971000997 RPB1 interaction site [polypeptide binding]; other site 698971000998 RPB10 interaction site [polypeptide binding]; other site 698971000999 RPB11 interaction site [polypeptide binding]; other site 698971001000 RPB3 interaction site [polypeptide binding]; other site 698971001001 RPB12 interaction site [polypeptide binding]; other site 698971001002 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 698971001003 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 698971001004 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 698971001005 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 698971001006 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 698971001007 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 698971001008 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 698971001009 G-loop; other site 698971001010 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 698971001011 DNA binding site [nucleotide binding] 698971001012 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 698971001013 Transposase; Region: DDE_Tnp_ISL3; pfam01610 698971001014 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698971001015 Histidine kinase; Region: HisKA_3; pfam07730 698971001016 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698971001017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698971001018 active site 698971001019 phosphorylation site [posttranslational modification] 698971001020 intermolecular recognition site; other site 698971001021 dimerization interface [polypeptide binding]; other site 698971001022 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698971001023 DNA binding residues [nucleotide binding] 698971001024 dimerization interface [polypeptide binding]; other site 698971001025 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698971001026 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 698971001027 Walker A/P-loop; other site 698971001028 ATP binding site [chemical binding]; other site 698971001029 Q-loop/lid; other site 698971001030 ABC transporter signature motif; other site 698971001031 Walker B; other site 698971001032 D-loop; other site 698971001033 H-loop/switch region; other site 698971001034 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 698971001035 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 698971001036 TIGR03943 family protein; Region: TIGR03943 698971001037 Predicted permeases [General function prediction only]; Region: COG0701 698971001038 Radical SAM superfamily; Region: Radical_SAM; pfam04055 698971001039 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698971001040 FeS/SAM binding site; other site 698971001041 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 698971001042 Class III ribonucleotide reductase; Region: RNR_III; cd01675 698971001043 effector binding site; other site 698971001044 active site 698971001045 Zn binding site [ion binding]; other site 698971001046 glycine loop; other site 698971001047 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 698971001048 S17 interaction site [polypeptide binding]; other site 698971001049 S8 interaction site; other site 698971001050 16S rRNA interaction site [nucleotide binding]; other site 698971001051 streptomycin interaction site [chemical binding]; other site 698971001052 23S rRNA interaction site [nucleotide binding]; other site 698971001053 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 698971001054 30S ribosomal protein S7; Validated; Region: PRK05302 698971001055 elongation factor G; Reviewed; Region: PRK00007 698971001056 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 698971001057 G1 box; other site 698971001058 putative GEF interaction site [polypeptide binding]; other site 698971001059 GTP/Mg2+ binding site [chemical binding]; other site 698971001060 Switch I region; other site 698971001061 G2 box; other site 698971001062 G3 box; other site 698971001063 Switch II region; other site 698971001064 G4 box; other site 698971001065 G5 box; other site 698971001066 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 698971001067 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 698971001068 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 698971001069 elongation factor Tu; Reviewed; Region: PRK00049 698971001070 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 698971001071 G1 box; other site 698971001072 GEF interaction site [polypeptide binding]; other site 698971001073 GTP/Mg2+ binding site [chemical binding]; other site 698971001074 Switch I region; other site 698971001075 G2 box; other site 698971001076 G3 box; other site 698971001077 Switch II region; other site 698971001078 G4 box; other site 698971001079 G5 box; other site 698971001080 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 698971001081 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 698971001082 Antibiotic Binding Site [chemical binding]; other site 698971001083 Predicted membrane protein [Function unknown]; Region: COG2323 698971001084 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 698971001085 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 698971001086 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 698971001087 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 698971001088 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 698971001089 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 698971001090 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 698971001091 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 698971001092 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 698971001093 putative translocon binding site; other site 698971001094 protein-rRNA interface [nucleotide binding]; other site 698971001095 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 698971001096 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 698971001097 G-X-X-G motif; other site 698971001098 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 698971001099 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 698971001100 23S rRNA interface [nucleotide binding]; other site 698971001101 5S rRNA interface [nucleotide binding]; other site 698971001102 putative antibiotic binding site [chemical binding]; other site 698971001103 L25 interface [polypeptide binding]; other site 698971001104 L27 interface [polypeptide binding]; other site 698971001105 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 698971001106 putative translocon interaction site; other site 698971001107 23S rRNA interface [nucleotide binding]; other site 698971001108 signal recognition particle (SRP54) interaction site; other site 698971001109 L23 interface [polypeptide binding]; other site 698971001110 trigger factor interaction site; other site 698971001111 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 698971001112 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698971001113 HlyD family secretion protein; Region: HlyD_3; pfam13437 698971001114 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698971001115 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698971001116 Walker A/P-loop; other site 698971001117 ATP binding site [chemical binding]; other site 698971001118 Q-loop/lid; other site 698971001119 ABC transporter signature motif; other site 698971001120 Walker B; other site 698971001121 D-loop; other site 698971001122 H-loop/switch region; other site 698971001123 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698971001124 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698971001125 FtsX-like permease family; Region: FtsX; pfam02687 698971001126 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 698971001127 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 698971001128 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 698971001129 RNA binding site [nucleotide binding]; other site 698971001130 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 698971001131 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 698971001132 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 698971001133 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 698971001134 serine transporter; Region: stp; TIGR00814 698971001135 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 698971001136 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 698971001137 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 698971001138 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 698971001139 active site 698971001140 homotetramer interface [polypeptide binding]; other site 698971001141 homodimer interface [polypeptide binding]; other site 698971001142 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK05597 698971001143 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 698971001144 ATP binding site [chemical binding]; other site 698971001145 substrate interface [chemical binding]; other site 698971001146 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698971001147 active site residue [active] 698971001148 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698971001149 MPT binding site; other site 698971001150 trimer interface [polypeptide binding]; other site 698971001151 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 698971001152 MoaE homodimer interface [polypeptide binding]; other site 698971001153 MoaD interaction [polypeptide binding]; other site 698971001154 active site residues [active] 698971001155 Predicted transcriptional regulator [Transcription]; Region: COG2345 698971001156 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 698971001157 DNA binding residues [nucleotide binding] 698971001158 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 698971001159 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698971001160 dimer interface [polypeptide binding]; other site 698971001161 conserved gate region; other site 698971001162 putative PBP binding loops; other site 698971001163 ABC-ATPase subunit interface; other site 698971001164 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698971001165 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 698971001166 Walker A/P-loop; other site 698971001167 ATP binding site [chemical binding]; other site 698971001168 Q-loop/lid; other site 698971001169 ABC transporter signature motif; other site 698971001170 Walker B; other site 698971001171 D-loop; other site 698971001172 H-loop/switch region; other site 698971001173 TOBE domain; Region: TOBE; cl01440 698971001174 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 698971001175 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698971001176 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698971001177 MULE transposase domain; Region: MULE; pfam10551 698971001178 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 698971001179 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 698971001180 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 698971001181 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 698971001182 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 698971001183 [4Fe-4S] binding site [ion binding]; other site 698971001184 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698971001185 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698971001186 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698971001187 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 698971001188 molybdopterin cofactor binding site; other site 698971001189 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 698971001190 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 698971001191 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698971001192 putative substrate translocation pore; other site 698971001193 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698971001194 MPT binding site; other site 698971001195 trimer interface [polypeptide binding]; other site 698971001196 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 698971001197 GTP binding site; other site 698971001198 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 698971001199 trimer interface [polypeptide binding]; other site 698971001200 dimer interface [polypeptide binding]; other site 698971001201 putative active site [active] 698971001202 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK14690 698971001203 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 698971001204 dimer interface [polypeptide binding]; other site 698971001205 putative functional site; other site 698971001206 putative MPT binding site; other site 698971001207 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 698971001208 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698971001209 FeS/SAM binding site; other site 698971001210 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 698971001211 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698971001212 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 698971001213 inhibitor site; inhibition site 698971001214 active site 698971001215 dimer interface [polypeptide binding]; other site 698971001216 catalytic residue [active] 698971001217 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 698971001218 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698971001219 Walker A/P-loop; other site 698971001220 ATP binding site [chemical binding]; other site 698971001221 Q-loop/lid; other site 698971001222 ABC transporter signature motif; other site 698971001223 Walker B; other site 698971001224 D-loop; other site 698971001225 H-loop/switch region; other site 698971001226 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698971001227 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698971001228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698971001229 dimer interface [polypeptide binding]; other site 698971001230 conserved gate region; other site 698971001231 putative PBP binding loops; other site 698971001232 ABC-ATPase subunit interface; other site 698971001233 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 698971001234 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698971001235 Walker A/P-loop; other site 698971001236 ATP binding site [chemical binding]; other site 698971001237 Q-loop/lid; other site 698971001238 ABC transporter signature motif; other site 698971001239 Walker B; other site 698971001240 D-loop; other site 698971001241 H-loop/switch region; other site 698971001242 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698971001243 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698971001244 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698971001245 dimer interface [polypeptide binding]; other site 698971001246 conserved gate region; other site 698971001247 putative PBP binding loops; other site 698971001248 ABC-ATPase subunit interface; other site 698971001249 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 698971001250 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698971001251 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 698971001252 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698971001253 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698971001254 DNA-binding site [nucleotide binding]; DNA binding site 698971001255 FCD domain; Region: FCD; pfam07729 698971001256 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698971001257 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698971001258 nucleotide binding site [chemical binding]; other site 698971001259 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 698971001260 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 698971001261 putative active site cavity [active] 698971001262 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 698971001263 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 698971001264 active site 698971001265 dimer interface [polypeptide binding]; other site 698971001266 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 698971001267 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 698971001268 active site 698971001269 trimer interface [polypeptide binding]; other site 698971001270 allosteric site; other site 698971001271 active site lid [active] 698971001272 hexamer (dimer of trimers) interface [polypeptide binding]; other site 698971001273 Htaa; Region: HtaA; pfam04213 698971001274 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 698971001275 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 698971001276 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 698971001277 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 698971001278 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 698971001279 5S rRNA interface [nucleotide binding]; other site 698971001280 L27 interface [polypeptide binding]; other site 698971001281 23S rRNA interface [nucleotide binding]; other site 698971001282 L5 interface [polypeptide binding]; other site 698971001283 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 698971001284 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 698971001285 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 698971001286 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 698971001287 23S rRNA binding site [nucleotide binding]; other site 698971001288 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 698971001289 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 698971001290 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 698971001291 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 698971001292 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698971001293 active site 698971001294 catalytic site [active] 698971001295 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698971001296 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 698971001297 active site 698971001298 catalytic site [active] 698971001299 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 698971001300 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698971001301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698971001302 dimer interface [polypeptide binding]; other site 698971001303 conserved gate region; other site 698971001304 putative PBP binding loops; other site 698971001305 ABC-ATPase subunit interface; other site 698971001306 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698971001307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698971001308 dimer interface [polypeptide binding]; other site 698971001309 conserved gate region; other site 698971001310 putative PBP binding loops; other site 698971001311 ABC-ATPase subunit interface; other site 698971001312 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 698971001313 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698971001314 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698971001315 Walker A/P-loop; other site 698971001316 ATP binding site [chemical binding]; other site 698971001317 Q-loop/lid; other site 698971001318 ABC transporter signature motif; other site 698971001319 Walker B; other site 698971001320 D-loop; other site 698971001321 H-loop/switch region; other site 698971001322 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 698971001323 SecY translocase; Region: SecY; pfam00344 698971001324 adenylate kinase; Reviewed; Region: adk; PRK00279 698971001325 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 698971001326 AMP-binding site [chemical binding]; other site 698971001327 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 698971001328 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 698971001329 active site 698971001330 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 698971001331 catalytic site [active] 698971001332 BNR repeat-like domain; Region: BNR_2; pfam13088 698971001333 Asp-box motif; other site 698971001334 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698971001335 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 698971001336 rRNA binding site [nucleotide binding]; other site 698971001337 predicted 30S ribosome binding site; other site 698971001338 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 698971001339 30S ribosomal protein S13; Region: bact_S13; TIGR03631 698971001340 30S ribosomal protein S11; Validated; Region: PRK05309 698971001341 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 698971001342 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 698971001343 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698971001344 RNA binding surface [nucleotide binding]; other site 698971001345 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 698971001346 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 698971001347 alphaNTD - beta interaction site [polypeptide binding]; other site 698971001348 alphaNTD homodimer interface [polypeptide binding]; other site 698971001349 alphaNTD - beta' interaction site [polypeptide binding]; other site 698971001350 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 698971001351 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 698971001352 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 698971001353 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 698971001354 dimerization interface 3.5A [polypeptide binding]; other site 698971001355 active site 698971001356 Protein of unknown function (DUF690); Region: DUF690; cl04939 698971001357 TIGR02611 family protein; Region: TIGR02611 698971001358 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 698971001359 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 698971001360 active site 698971001361 catalytic residues [active] 698971001362 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 698971001363 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 698971001364 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698971001365 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 698971001366 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698971001367 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698971001368 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 698971001369 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 698971001370 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 698971001371 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 698971001372 23S rRNA interface [nucleotide binding]; other site 698971001373 L3 interface [polypeptide binding]; other site 698971001374 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 698971001375 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 698971001376 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 698971001377 active site 698971001378 substrate binding site [chemical binding]; other site 698971001379 metal binding site [ion binding]; metal-binding site 698971001380 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 698971001381 alanine racemase; Reviewed; Region: alr; PRK00053 698971001382 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 698971001383 active site 698971001384 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698971001385 dimer interface [polypeptide binding]; other site 698971001386 substrate binding site [chemical binding]; other site 698971001387 catalytic residues [active] 698971001388 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 698971001389 Predicted permease [General function prediction only]; Region: COG2985 698971001390 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 698971001391 TrkA-C domain; Region: TrkA_C; pfam02080 698971001392 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 698971001393 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 698971001394 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 698971001395 Glycoprotease family; Region: Peptidase_M22; pfam00814 698971001396 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698971001397 Coenzyme A binding pocket [chemical binding]; other site 698971001398 UGMP family protein; Validated; Region: PRK09604 698971001399 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 698971001400 oligomerisation interface [polypeptide binding]; other site 698971001401 mobile loop; other site 698971001402 roof hairpin; other site 698971001403 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 698971001404 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 698971001405 ring oligomerisation interface [polypeptide binding]; other site 698971001406 ATP/Mg binding site [chemical binding]; other site 698971001407 stacking interactions; other site 698971001408 hinge regions; other site 698971001409 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 698971001410 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698971001411 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698971001412 DNA binding residues [nucleotide binding] 698971001413 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 698971001414 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698971001415 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 698971001416 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 698971001417 active site 698971001418 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 698971001419 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698971001420 phosphate binding site [ion binding]; other site 698971001421 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698971001422 siderophore binding site; other site 698971001423 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698971001424 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698971001425 dimer interface [polypeptide binding]; other site 698971001426 putative PBP binding regions; other site 698971001427 ABC-ATPase subunit interface; other site 698971001428 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698971001429 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698971001430 ABC-ATPase subunit interface; other site 698971001431 dimer interface [polypeptide binding]; other site 698971001432 putative PBP binding regions; other site 698971001433 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698971001434 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698971001435 Walker A/P-loop; other site 698971001436 ATP binding site [chemical binding]; other site 698971001437 Q-loop/lid; other site 698971001438 ABC transporter signature motif; other site 698971001439 Walker B; other site 698971001440 D-loop; other site 698971001441 H-loop/switch region; other site 698971001442 IucA / IucC family; Region: IucA_IucC; pfam04183 698971001443 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 698971001444 IucA / IucC family; Region: IucA_IucC; pfam04183 698971001445 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 698971001446 H+ Antiporter protein; Region: 2A0121; TIGR00900 698971001447 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 698971001448 EamA-like transporter family; Region: EamA; pfam00892 698971001449 GMP synthase; Reviewed; Region: guaA; PRK00074 698971001450 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 698971001451 AMP/PPi binding site [chemical binding]; other site 698971001452 candidate oxyanion hole; other site 698971001453 catalytic triad [active] 698971001454 potential glutamine specificity residues [chemical binding]; other site 698971001455 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 698971001456 ATP Binding subdomain [chemical binding]; other site 698971001457 Ligand Binding sites [chemical binding]; other site 698971001458 Dimerization subdomain; other site 698971001459 PspC domain; Region: PspC; pfam04024 698971001460 PspC domain; Region: PspC; pfam04024 698971001461 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698971001462 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 698971001463 ATP binding site [chemical binding]; other site 698971001464 Mg2+ binding site [ion binding]; other site 698971001465 G-X-G motif; other site 698971001466 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698971001467 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698971001468 active site 698971001469 phosphorylation site [posttranslational modification] 698971001470 intermolecular recognition site; other site 698971001471 dimerization interface [polypeptide binding]; other site 698971001472 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698971001473 DNA binding residues [nucleotide binding] 698971001474 dimerization interface [polypeptide binding]; other site 698971001475 potential frameshift: common BLAST hit: gi|38233680|ref|NP_939447.1| iron transport system exported solute-binding component 698971001476 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698971001477 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698971001478 DNA Polymerase Y-family; Region: PolY_like; cd03468 698971001479 active site 698971001480 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 698971001481 DNA binding site [nucleotide binding] 698971001482 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 698971001483 putative dimer interface [polypeptide binding]; other site 698971001484 putative [2Fe-2S] cluster binding site [ion binding]; other site 698971001485 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698971001486 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 698971001487 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698971001488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698971001489 dimer interface [polypeptide binding]; other site 698971001490 conserved gate region; other site 698971001491 ABC-ATPase subunit interface; other site 698971001492 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 698971001493 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 698971001494 Walker A/P-loop; other site 698971001495 ATP binding site [chemical binding]; other site 698971001496 Q-loop/lid; other site 698971001497 ABC transporter signature motif; other site 698971001498 Walker B; other site 698971001499 D-loop; other site 698971001500 H-loop/switch region; other site 698971001501 NIL domain; Region: NIL; cl09633 698971001502 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 698971001503 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 698971001504 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 698971001505 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 698971001506 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 698971001507 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 698971001508 active site 698971001509 PHP Thumb interface [polypeptide binding]; other site 698971001510 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 698971001511 Uncharacterized conserved protein [Function unknown]; Region: COG3402 698971001512 Predicted membrane protein [Function unknown]; Region: COG3428 698971001513 Bacterial PH domain; Region: DUF304; pfam03703 698971001514 Bacterial PH domain; Region: DUF304; pfam03703 698971001515 Bacterial PH domain; Region: DUF304; pfam03703 698971001516 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698971001517 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698971001518 intersubunit interface [polypeptide binding]; other site 698971001519 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698971001520 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698971001521 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698971001522 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698971001523 dimer interface [polypeptide binding]; other site 698971001524 putative PBP binding regions; other site 698971001525 ABC-ATPase subunit interface; other site 698971001526 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698971001527 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698971001528 ABC-ATPase subunit interface; other site 698971001529 dimer interface [polypeptide binding]; other site 698971001530 putative PBP binding regions; other site 698971001531 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 698971001532 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 698971001533 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 698971001534 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 698971001535 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 698971001536 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 698971001537 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 698971001538 homodimer interface [polypeptide binding]; other site 698971001539 NADP binding site [chemical binding]; other site 698971001540 substrate binding site [chemical binding]; other site 698971001541 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 698971001542 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698971001543 active site 698971001544 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 698971001545 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 698971001546 Htaa; Region: HtaA; pfam04213 698971001547 Htaa; Region: HtaA; pfam04213 698971001548 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698971001549 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 698971001550 intersubunit interface [polypeptide binding]; other site 698971001551 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698971001552 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698971001553 ABC-ATPase subunit interface; other site 698971001554 dimer interface [polypeptide binding]; other site 698971001555 putative PBP binding regions; other site 698971001556 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 698971001557 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698971001558 Walker A/P-loop; other site 698971001559 ATP binding site [chemical binding]; other site 698971001560 Q-loop/lid; other site 698971001561 ABC transporter signature motif; other site 698971001562 Walker B; other site 698971001563 D-loop; other site 698971001564 H-loop/switch region; other site 698971001565 Htaa; Region: HtaA; pfam04213 698971001566 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05613 698971001567 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 698971001568 homodimer interface [polypeptide binding]; other site 698971001569 substrate-cofactor binding pocket; other site 698971001570 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698971001571 catalytic residue [active] 698971001572 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 698971001573 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 698971001574 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 698971001575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698971001576 putative substrate translocation pore; other site 698971001577 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 698971001578 putative catalytic site [active] 698971001579 putative metal binding site [ion binding]; other site 698971001580 putative phosphate binding site [ion binding]; other site 698971001581 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 698971001582 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 698971001583 active site 698971001584 HIGH motif; other site 698971001585 dimer interface [polypeptide binding]; other site 698971001586 KMSKS motif; other site 698971001587 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 698971001588 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 698971001589 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 698971001590 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698971001591 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698971001592 NlpC/P60 family; Region: NLPC_P60; pfam00877 698971001593 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698971001594 active site 698971001595 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698971001596 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698971001597 non-specific DNA binding site [nucleotide binding]; other site 698971001598 salt bridge; other site 698971001599 sequence-specific DNA binding site [nucleotide binding]; other site 698971001600 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698971001601 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 698971001602 metal binding site [ion binding]; metal-binding site 698971001603 putative dimer interface [polypeptide binding]; other site 698971001604 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 698971001605 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698971001606 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698971001607 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698971001608 pyruvate carboxylase; Reviewed; Region: PRK12999 698971001609 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698971001610 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698971001611 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 698971001612 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 698971001613 active site 698971001614 catalytic residues [active] 698971001615 metal binding site [ion binding]; metal-binding site 698971001616 homodimer binding site [polypeptide binding]; other site 698971001617 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698971001618 carboxyltransferase (CT) interaction site; other site 698971001619 biotinylation site [posttranslational modification]; other site 698971001620 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749 698971001621 ADP-ribose binding site [chemical binding]; other site 698971001622 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 698971001623 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698971001624 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 698971001625 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 698971001626 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698971001627 carboxyltransferase (CT) interaction site; other site 698971001628 biotinylation site [posttranslational modification]; other site 698971001629 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 698971001630 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698971001631 active site residue [active] 698971001632 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 698971001633 active site residue [active] 698971001634 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698971001635 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 698971001636 active site 698971001637 dimer interface [polypeptide binding]; other site 698971001638 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 698971001639 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698971001640 substrate binding site [chemical binding]; other site 698971001641 dimer interface [polypeptide binding]; other site 698971001642 ATP binding site [chemical binding]; other site 698971001643 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698971001644 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698971001645 DNA binding site [nucleotide binding] 698971001646 domain linker motif; other site 698971001647 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 698971001648 dimerization interface [polypeptide binding]; other site 698971001649 putative ligand binding site [chemical binding]; other site 698971001650 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 698971001651 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698971001652 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698971001653 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698971001654 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698971001655 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698971001656 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698971001657 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 698971001658 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 698971001659 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 698971001660 ATP-grasp domain; Region: ATP-grasp; pfam02222 698971001661 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 698971001662 Uncharacterized conserved protein [Function unknown]; Region: COG1434 698971001663 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 698971001664 putative active site [active] 698971001665 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 698971001666 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 698971001667 HupF/HypC family; Region: HupF_HypC; pfam01455 698971001668 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 698971001669 dimerization interface [polypeptide binding]; other site 698971001670 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 698971001671 ATP binding site [chemical binding]; other site 698971001672 Acylphosphatase; Region: Acylphosphatase; pfam00708 698971001673 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 698971001674 HypF finger; Region: zf-HYPF; pfam07503 698971001675 HypF finger; Region: zf-HYPF; pfam07503 698971001676 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 698971001677 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698971001678 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 698971001679 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 698971001680 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 698971001681 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 698971001682 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 698971001683 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 698971001684 putative substrate-binding site; other site 698971001685 nickel binding site [ion binding]; other site 698971001686 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 698971001687 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 698971001688 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 698971001689 HupF/HypC family; Region: HupF_HypC; pfam01455 698971001690 TIGR03089 family protein; Region: TIGR03089 698971001691 Transcriptional regulator [Transcription]; Region: LytR; COG1316 698971001692 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 698971001693 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 698971001694 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698971001695 active site 698971001696 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698971001697 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 698971001698 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 698971001699 active site 698971001700 Substrate binding site; other site 698971001701 Mg++ binding site; other site 698971001702 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698971001703 putative trimer interface [polypeptide binding]; other site 698971001704 putative CoA binding site [chemical binding]; other site 698971001705 Transcription factor WhiB; Region: Whib; pfam02467 698971001706 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 698971001707 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 698971001708 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 698971001709 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 698971001710 active site 698971001711 substrate binding site [chemical binding]; other site 698971001712 metal binding site [ion binding]; metal-binding site 698971001713 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 698971001714 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 698971001715 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 698971001716 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 698971001717 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 698971001718 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 698971001719 homotetramer interface [polypeptide binding]; other site 698971001720 ligand binding site [chemical binding]; other site 698971001721 catalytic site [active] 698971001722 NAD binding site [chemical binding]; other site 698971001723 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 698971001724 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 698971001725 TMP-binding site; other site 698971001726 ATP-binding site [chemical binding]; other site 698971001727 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698971001728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698971001729 active site 698971001730 phosphorylation site [posttranslational modification] 698971001731 intermolecular recognition site; other site 698971001732 dimerization interface [polypeptide binding]; other site 698971001733 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698971001734 DNA binding site [nucleotide binding] 698971001735 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698971001736 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698971001737 dimerization interface [polypeptide binding]; other site 698971001738 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698971001739 dimer interface [polypeptide binding]; other site 698971001740 phosphorylation site [posttranslational modification] 698971001741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698971001742 ATP binding site [chemical binding]; other site 698971001743 Mg2+ binding site [ion binding]; other site 698971001744 G-X-G motif; other site 698971001745 lipoprotein LpqB; Provisional; Region: PRK13616 698971001746 Sporulation and spore germination; Region: Germane; pfam10646 698971001747 comF family protein; Region: comF; TIGR00201 698971001748 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698971001749 active site 698971001750 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 698971001751 30S subunit binding site; other site 698971001752 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 698971001753 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698971001754 ATP binding site [chemical binding]; other site 698971001755 putative Mg++ binding site [ion binding]; other site 698971001756 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 698971001757 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698971001758 nucleotide binding region [chemical binding]; other site 698971001759 ATP-binding site [chemical binding]; other site 698971001760 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 698971001761 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 698971001762 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 698971001763 FAD binding pocket [chemical binding]; other site 698971001764 FAD binding motif [chemical binding]; other site 698971001765 phosphate binding motif [ion binding]; other site 698971001766 beta-alpha-beta structure motif; other site 698971001767 NAD binding pocket [chemical binding]; other site 698971001768 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698971001769 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 698971001770 catalytic loop [active] 698971001771 iron binding site [ion binding]; other site 698971001772 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 698971001773 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 698971001774 putative di-iron ligands [ion binding]; other site 698971001775 Predicted GTPases [General function prediction only]; Region: COG1162 698971001776 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 698971001777 GTPase/Zn-binding domain interface [polypeptide binding]; other site 698971001778 GTP/Mg2+ binding site [chemical binding]; other site 698971001779 G4 box; other site 698971001780 G5 box; other site 698971001781 G1 box; other site 698971001782 Switch I region; other site 698971001783 G2 box; other site 698971001784 G3 box; other site 698971001785 Switch II region; other site 698971001786 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 698971001787 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 698971001788 active site 698971001789 hinge; other site 698971001790 Uncharacterized conserved protein [Function unknown]; Region: COG2135 698971001791 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 698971001792 putative deacylase active site [active] 698971001793 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 698971001794 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698971001795 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698971001796 DNA binding residues [nucleotide binding] 698971001797 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 698971001798 Transcription factor WhiB; Region: Whib; pfam02467 698971001799 PQQ-like domain; Region: PQQ_2; pfam13360 698971001800 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698971001801 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698971001802 ATP binding site [chemical binding]; other site 698971001803 putative Mg++ binding site [ion binding]; other site 698971001804 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698971001805 nucleotide binding region [chemical binding]; other site 698971001806 ATP-binding site [chemical binding]; other site 698971001807 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 698971001808 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 698971001809 TIGR02569 family protein; Region: TIGR02569_actnb 698971001810 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698971001811 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 698971001812 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 698971001813 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698971001814 Part of AAA domain; Region: AAA_19; pfam13245 698971001815 Family description; Region: UvrD_C_2; pfam13538 698971001816 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 698971001817 Ion channel; Region: Ion_trans_2; pfam07885 698971001818 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 698971001819 TrkA-N domain; Region: TrkA_N; pfam02254 698971001820 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 698971001821 putative NADH binding site [chemical binding]; other site 698971001822 putative active site [active] 698971001823 nudix motif; other site 698971001824 putative metal binding site [ion binding]; other site 698971001825 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 698971001826 Part of AAA domain; Region: AAA_19; pfam13245 698971001827 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698971001828 Family description; Region: UvrD_C_2; pfam13538 698971001829 HRDC domain; Region: HRDC; pfam00570 698971001830 Protein of unknown function DUF45; Region: DUF45; pfam01863 698971001831 putative hydrolase; Region: TIGR03624 698971001832 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 698971001833 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698971001834 hypothetical protein; Validated; Region: PRK00068 698971001835 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 698971001836 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 698971001837 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 698971001838 active site 698971001839 Protein of unknown function (DUF418); Region: DUF418; cl12135 698971001840 oxaloacetate decarboxylase; Provisional; Region: PRK12330 698971001841 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 698971001842 active site 698971001843 catalytic residues [active] 698971001844 metal binding site [ion binding]; metal-binding site 698971001845 homodimer binding site [polypeptide binding]; other site 698971001846 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 698971001847 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698971001848 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698971001849 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698971001850 carboxyltransferase (CT) interaction site; other site 698971001851 biotinylation site [posttranslational modification]; other site 698971001852 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698971001853 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 698971001854 active site 698971001855 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 698971001856 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698971001857 active site 698971001858 peptide chain release factor 2; Validated; Region: prfB; PRK00578 698971001859 This domain is found in peptide chain release factors; Region: PCRF; smart00937 698971001860 RF-1 domain; Region: RF-1; pfam00472 698971001861 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 698971001862 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 698971001863 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 698971001864 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698971001865 Walker A/P-loop; other site 698971001866 ATP binding site [chemical binding]; other site 698971001867 Q-loop/lid; other site 698971001868 ABC transporter signature motif; other site 698971001869 Walker B; other site 698971001870 D-loop; other site 698971001871 H-loop/switch region; other site 698971001872 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 698971001873 FtsX-like permease family; Region: FtsX; pfam02687 698971001874 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 698971001875 SmpB-tmRNA interface; other site 698971001876 potential frameshift: common BLAST hit: gi|38234527|ref|NP_940294.1| transposase 698971001877 potential frameshift: common BLAST hit: gi|38233854|ref|NP_939621.1| transposase 698971001878 HTH-like domain; Region: HTH_21; pfam13276 698971001879 Integrase core domain; Region: rve; pfam00665 698971001880 Integrase core domain; Region: rve_2; pfam13333 698971001881 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698971001882 MULE transposase domain; Region: MULE; pfam10551 698971001883 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 698971001884 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 698971001885 active site 698971001886 zinc binding site [ion binding]; other site 698971001887 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39F; cd02425 698971001888 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 698971001889 putative active site [active] 698971001890 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698971001891 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 698971001892 Walker A/P-loop; other site 698971001893 ATP binding site [chemical binding]; other site 698971001894 Q-loop/lid; other site 698971001895 ABC transporter signature motif; other site 698971001896 Walker B; other site 698971001897 D-loop; other site 698971001898 H-loop/switch region; other site 698971001899 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698971001900 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 698971001901 Walker A/P-loop; other site 698971001902 ATP binding site [chemical binding]; other site 698971001903 Q-loop/lid; other site 698971001904 ABC transporter signature motif; other site 698971001905 Walker B; other site 698971001906 D-loop; other site 698971001907 H-loop/switch region; other site 698971001908 Integrase core domain; Region: rve_3; pfam13683 698971001909 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698971001910 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698971001911 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 698971001912 DNA-binding interface [nucleotide binding]; DNA binding site 698971001913 HTH-like domain; Region: HTH_21; pfam13276 698971001914 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698971001915 Integrase core domain; Region: rve; pfam00665 698971001916 Integrase core domain; Region: rve_3; pfam13683 698971001917 Cupin domain; Region: Cupin_2; cl17218 698971001918 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698971001919 S-adenosylmethionine binding site [chemical binding]; other site 698971001920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698971001921 Integrase core domain; Region: rve_3; pfam13683 698971001922 potential frameshift: common BLAST hit: gi|38233368|ref|NP_939135.1| transposase 698971001923 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698971001924 Integrase core domain; Region: rve; pfam00665 698971001925 Helix-turn-helix domain; Region: HTH_38; pfam13936 698971001926 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698971001927 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698971001928 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698971001929 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698971001930 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698971001931 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 698971001932 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 698971001933 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698971001934 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698971001935 nucleotide binding region [chemical binding]; other site 698971001936 ATP-binding site [chemical binding]; other site 698971001937 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 698971001938 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 698971001939 Protein of unknown function (DUF3235); Region: DUF3235; pfam11574 698971001940 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698971001941 DNA-binding site [nucleotide binding]; DNA binding site 698971001942 RNA-binding motif; other site 698971001943 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 698971001944 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 698971001945 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 698971001946 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 698971001947 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698971001948 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698971001949 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 698971001950 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698971001951 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698971001952 catalytic residue [active] 698971001953 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 698971001954 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 698971001955 dimer interface [polypeptide binding]; other site 698971001956 active site 698971001957 citrylCoA binding site [chemical binding]; other site 698971001958 NADH binding [chemical binding]; other site 698971001959 cationic pore residues; other site 698971001960 oxalacetate/citrate binding site [chemical binding]; other site 698971001961 coenzyme A binding site [chemical binding]; other site 698971001962 catalytic triad [active] 698971001963 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 698971001964 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 698971001965 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698971001966 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698971001967 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698971001968 active site 698971001969 catalytic tetrad [active] 698971001970 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 698971001971 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698971001972 substrate binding site [chemical binding]; other site 698971001973 oxyanion hole (OAH) forming residues; other site 698971001974 trimer interface [polypeptide binding]; other site 698971001975 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698971001976 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698971001977 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698971001978 Protein of unknown function, DUF485; Region: DUF485; pfam04341 698971001979 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 698971001980 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 698971001981 Na binding site [ion binding]; other site 698971001982 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 698971001983 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 698971001984 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 698971001985 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 698971001986 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 698971001987 active site 698971001988 catalytic residues [active] 698971001989 DNA binding site [nucleotide binding] 698971001990 Int/Topo IB signature motif; other site 698971001991 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698971001992 sequence-specific DNA binding site [nucleotide binding]; other site 698971001993 salt bridge; other site 698971001994 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 698971001995 active site 698971001996 catalytic residues [active] 698971001997 DNA binding site [nucleotide binding] 698971001998 Int/Topo IB signature motif; other site 698971001999 Homeodomain-like domain; Region: HTH_23; cl17451 698971002000 Helix-turn-helix domain; Region: HTH_28; pfam13518 698971002001 putative transposase OrfB; Reviewed; Region: PHA02517 698971002002 HTH-like domain; Region: HTH_21; pfam13276 698971002003 Integrase core domain; Region: rve; pfam00665 698971002004 Integrase core domain; Region: rve_2; pfam13333 698971002005 XamI restriction endonuclease; Region: RE_XamI; pfam09572 698971002006 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698971002007 S-adenosylmethionine binding site [chemical binding]; other site 698971002008 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 698971002009 potential frameshift: common BLAST hit: gi|68536877|ref|YP_251582.1| transposase IS3508i 698971002010 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698971002011 MULE transposase domain; Region: MULE; pfam10551 698971002012 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 698971002013 active site 698971002014 SAM binding site [chemical binding]; other site 698971002015 homodimer interface [polypeptide binding]; other site 698971002016 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 698971002017 catalytic residues [active] 698971002018 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 698971002019 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 698971002020 folate binding site [chemical binding]; other site 698971002021 NADP+ binding site [chemical binding]; other site 698971002022 thymidylate synthase; Reviewed; Region: thyA; PRK01827 698971002023 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 698971002024 dimerization interface [polypeptide binding]; other site 698971002025 active site 698971002026 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 698971002027 active site 698971002028 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698971002029 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 698971002030 ATP binding site [chemical binding]; other site 698971002031 putative Mg++ binding site [ion binding]; other site 698971002032 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698971002033 nucleotide binding region [chemical binding]; other site 698971002034 ATP-binding site [chemical binding]; other site 698971002035 DEAD/H associated; Region: DEAD_assoc; pfam08494 698971002036 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 698971002037 active site 698971002038 SUMO-1 interface [polypeptide binding]; other site 698971002039 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 698971002040 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 698971002041 putative DNA binding site [nucleotide binding]; other site 698971002042 catalytic residue [active] 698971002043 putative H2TH interface [polypeptide binding]; other site 698971002044 putative catalytic residues [active] 698971002045 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698971002046 Predicted permease [General function prediction only]; Region: COG2985 698971002047 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 698971002048 TrkA-C domain; Region: TrkA_C; pfam02080 698971002049 TrkA-C domain; Region: TrkA_C; pfam02080 698971002050 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 698971002051 hypothetical protein; Provisional; Region: PRK11770 698971002052 Domain of unknown function (DUF307); Region: DUF307; pfam03733 698971002053 Domain of unknown function (DUF307); Region: DUF307; pfam03733 698971002054 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 698971002055 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 698971002056 active site 698971002057 dimer interface [polypeptide binding]; other site 698971002058 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 698971002059 dimer interface [polypeptide binding]; other site 698971002060 active site 698971002061 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698971002062 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 698971002063 tetramerization interface [polypeptide binding]; other site 698971002064 NAD(P) binding site [chemical binding]; other site 698971002065 catalytic residues [active] 698971002066 hypothetical protein; Provisional; Region: PRK07857 698971002067 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 698971002068 Part of AAA domain; Region: AAA_19; pfam13245 698971002069 Family description; Region: UvrD_C_2; pfam13538 698971002070 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 698971002071 Peptidase family M23; Region: Peptidase_M23; pfam01551 698971002072 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 698971002073 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 698971002074 active site 698971002075 substrate binding site [chemical binding]; other site 698971002076 cosubstrate binding site; other site 698971002077 catalytic site [active] 698971002078 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 698971002079 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 698971002080 purine monophosphate binding site [chemical binding]; other site 698971002081 dimer interface [polypeptide binding]; other site 698971002082 putative catalytic residues [active] 698971002083 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 698971002084 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 698971002085 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 698971002086 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698971002087 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698971002088 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 698971002089 30S ribosomal protein S18; Provisional; Region: PRK13401 698971002090 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 698971002091 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 698971002092 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 698971002093 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 698971002094 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 698971002095 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698971002096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698971002097 active site 698971002098 phosphorylation site [posttranslational modification] 698971002099 intermolecular recognition site; other site 698971002100 dimerization interface [polypeptide binding]; other site 698971002101 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698971002102 DNA binding site [nucleotide binding] 698971002103 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 698971002104 dimerization interface [polypeptide binding]; other site 698971002105 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698971002106 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698971002107 dimer interface [polypeptide binding]; other site 698971002108 phosphorylation site [posttranslational modification] 698971002109 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698971002110 ATP binding site [chemical binding]; other site 698971002111 Mg2+ binding site [ion binding]; other site 698971002112 G-X-G motif; other site 698971002113 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 698971002114 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698971002115 protein binding site [polypeptide binding]; other site 698971002116 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698971002117 MPT binding site; other site 698971002118 trimer interface [polypeptide binding]; other site 698971002119 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 698971002120 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 698971002121 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 698971002122 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 698971002123 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 698971002124 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 698971002125 active site 698971002126 tetramer interface; other site 698971002127 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 698971002128 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 698971002129 dimer interface [polypeptide binding]; other site 698971002130 putative functional site; other site 698971002131 putative MPT binding site; other site 698971002132 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698971002133 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698971002134 Predicted membrane protein [Function unknown]; Region: COG2259 698971002135 Predicted integral membrane protein [Function unknown]; Region: COG5660 698971002136 Putative zinc-finger; Region: zf-HC2; pfam13490 698971002137 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 698971002138 BCCT family transporter; Region: BCCT; pfam02028 698971002139 Uncharacterized membrane protein [Function unknown]; Region: COG3949 698971002140 Predicted methyltransferases [General function prediction only]; Region: COG0313 698971002141 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 698971002142 putative SAM binding site [chemical binding]; other site 698971002143 putative homodimer interface [polypeptide binding]; other site 698971002144 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 698971002145 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 698971002146 active site 698971002147 HIGH motif; other site 698971002148 KMSKS motif; other site 698971002149 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 698971002150 tRNA binding surface [nucleotide binding]; other site 698971002151 anticodon binding site; other site 698971002152 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 698971002153 active site 698971002154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 698971002155 Domain of unknown function (DUF348); Region: DUF348; pfam03990 698971002156 Domain of unknown function (DUF348); Region: DUF348; pfam03990 698971002157 Domain of unknown function (DUF348); Region: DUF348; pfam03990 698971002158 G5 domain; Region: G5; pfam07501 698971002159 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 698971002160 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 698971002161 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698971002162 S-adenosylmethionine binding site [chemical binding]; other site 698971002163 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 698971002164 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 698971002165 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698971002166 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698971002167 ABC transporter; Region: ABC_tran_2; pfam12848 698971002168 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698971002169 Uncharacterized conserved protein [Function unknown]; Region: COG1359 698971002170 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 698971002171 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698971002172 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698971002173 DNA binding residues [nucleotide binding] 698971002174 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 698971002175 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 698971002176 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698971002177 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698971002178 active site 698971002179 motif I; other site 698971002180 motif II; other site 698971002181 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 698971002182 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 698971002183 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698971002184 substrate binding site [chemical binding]; other site 698971002185 oxyanion hole (OAH) forming residues; other site 698971002186 trimer interface [polypeptide binding]; other site 698971002187 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 698971002188 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698971002189 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698971002190 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 698971002191 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 698971002192 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 698971002193 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 698971002194 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 698971002195 G1 box; other site 698971002196 putative GEF interaction site [polypeptide binding]; other site 698971002197 GTP/Mg2+ binding site [chemical binding]; other site 698971002198 Switch I region; other site 698971002199 G2 box; other site 698971002200 G3 box; other site 698971002201 Switch II region; other site 698971002202 G4 box; other site 698971002203 G5 box; other site 698971002204 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 698971002205 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 698971002206 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698971002207 NAD(P) binding site [chemical binding]; other site 698971002208 active site 698971002209 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 698971002210 putative active site [active] 698971002211 catalytic residue [active] 698971002212 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698971002213 active site 698971002214 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 698971002215 putative active site [active] 698971002216 catalytic residue [active] 698971002217 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 698971002218 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 698971002219 5S rRNA interface [nucleotide binding]; other site 698971002220 CTC domain interface [polypeptide binding]; other site 698971002221 L16 interface [polypeptide binding]; other site 698971002222 pullulanase, type I; Region: pulA_typeI; TIGR02104 698971002223 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 698971002224 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 698971002225 Ca binding site [ion binding]; other site 698971002226 active site 698971002227 catalytic site [active] 698971002228 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 698971002229 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 698971002230 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698971002231 active site 698971002232 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 698971002233 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 698971002234 Substrate binding site; other site 698971002235 Mg++ binding site; other site 698971002236 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 698971002237 active site 698971002238 substrate binding site [chemical binding]; other site 698971002239 CoA binding site [chemical binding]; other site 698971002240 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698971002241 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698971002242 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 698971002243 putative dimerization interface [polypeptide binding]; other site 698971002244 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 698971002245 gating phenylalanine in ion channel; other site 698971002246 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 698971002247 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 698971002248 putative ligand binding site [chemical binding]; other site 698971002249 putative NAD binding site [chemical binding]; other site 698971002250 catalytic site [active] 698971002251 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698971002252 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698971002253 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698971002254 Q-loop/lid; other site 698971002255 ABC transporter signature motif; other site 698971002256 Walker B; other site 698971002257 D-loop; other site 698971002258 H-loop/switch region; other site 698971002259 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698971002260 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698971002261 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698971002262 Walker A/P-loop; other site 698971002263 ATP binding site [chemical binding]; other site 698971002264 Q-loop/lid; other site 698971002265 ABC transporter signature motif; other site 698971002266 Walker B; other site 698971002267 D-loop; other site 698971002268 H-loop/switch region; other site 698971002269 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698971002270 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698971002271 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 698971002272 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 698971002273 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698971002274 ATP binding site [chemical binding]; other site 698971002275 putative Mg++ binding site [ion binding]; other site 698971002276 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698971002277 nucleotide binding region [chemical binding]; other site 698971002278 ATP-binding site [chemical binding]; other site 698971002279 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 698971002280 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 698971002281 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 698971002282 homodimer interface [polypeptide binding]; other site 698971002283 metal binding site [ion binding]; metal-binding site 698971002284 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 698971002285 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 698971002286 enolase; Provisional; Region: eno; PRK00077 698971002287 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 698971002288 dimer interface [polypeptide binding]; other site 698971002289 metal binding site [ion binding]; metal-binding site 698971002290 substrate binding pocket [chemical binding]; other site 698971002291 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 698971002292 Septum formation initiator; Region: DivIC; pfam04977 698971002293 Uncharacterized conserved protein [Function unknown]; Region: COG1507 698971002294 exopolyphosphatase; Region: exo_poly_only; TIGR03706 698971002295 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 698971002296 Helix-turn-helix domain; Region: HTH_18; pfam12833 698971002297 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698971002298 Bax inhibitor 1 like; Region: BaxI_1; cl17691 698971002299 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 698971002300 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 698971002301 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 698971002302 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 698971002303 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 698971002304 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 698971002305 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 698971002306 catalytic residue [active] 698971002307 putative FPP diphosphate binding site; other site 698971002308 putative FPP binding hydrophobic cleft; other site 698971002309 dimer interface [polypeptide binding]; other site 698971002310 putative IPP diphosphate binding site; other site 698971002311 Flavodoxin domain; Region: Flavodoxin_5; cl17428 698971002312 pantothenate kinase; Provisional; Region: PRK05439 698971002313 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 698971002314 ATP-binding site [chemical binding]; other site 698971002315 CoA-binding site [chemical binding]; other site 698971002316 Mg2+-binding site [ion binding]; other site 698971002317 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 698971002318 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 698971002319 dimer interface [polypeptide binding]; other site 698971002320 active site 698971002321 glycine-pyridoxal phosphate binding site [chemical binding]; other site 698971002322 folate binding site [chemical binding]; other site 698971002323 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698971002324 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 698971002325 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698971002326 Coenzyme A binding pocket [chemical binding]; other site 698971002327 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 698971002328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698971002329 putative substrate translocation pore; other site 698971002330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698971002331 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698971002332 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698971002333 fumarate hydratase; Reviewed; Region: fumC; PRK00485 698971002334 Class II fumarases; Region: Fumarase_classII; cd01362 698971002335 active site 698971002336 tetramer interface [polypeptide binding]; other site 698971002337 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 698971002338 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 698971002339 putative active site [active] 698971002340 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 698971002341 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 698971002342 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 698971002343 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 698971002344 generic binding surface II; other site 698971002345 generic binding surface I; other site 698971002346 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 698971002347 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 698971002348 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698971002349 Domain of unknown function DUF20; Region: UPF0118; pfam01594 698971002350 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 698971002351 Na2 binding site [ion binding]; other site 698971002352 putative substrate binding site 1 [chemical binding]; other site 698971002353 Na binding site 1 [ion binding]; other site 698971002354 putative substrate binding site 2 [chemical binding]; other site 698971002355 GTP-binding protein YchF; Reviewed; Region: PRK09601 698971002356 YchF GTPase; Region: YchF; cd01900 698971002357 G1 box; other site 698971002358 GTP/Mg2+ binding site [chemical binding]; other site 698971002359 Switch I region; other site 698971002360 G2 box; other site 698971002361 Switch II region; other site 698971002362 G3 box; other site 698971002363 G4 box; other site 698971002364 G5 box; other site 698971002365 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 698971002366 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 698971002367 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 698971002368 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 698971002369 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 698971002370 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 698971002371 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 698971002372 Cl- selectivity filter; other site 698971002373 Cl- binding residues [ion binding]; other site 698971002374 pore gating glutamate residue; other site 698971002375 dimer interface [polypeptide binding]; other site 698971002376 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698971002377 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698971002378 Walker A/P-loop; other site 698971002379 ATP binding site [chemical binding]; other site 698971002380 Q-loop/lid; other site 698971002381 ABC transporter signature motif; other site 698971002382 Walker B; other site 698971002383 D-loop; other site 698971002384 H-loop/switch region; other site 698971002385 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 698971002386 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698971002387 Walker A/P-loop; other site 698971002388 ATP binding site [chemical binding]; other site 698971002389 Q-loop/lid; other site 698971002390 ABC transporter signature motif; other site 698971002391 Walker B; other site 698971002392 D-loop; other site 698971002393 H-loop/switch region; other site 698971002394 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 698971002395 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 698971002396 active site 698971002397 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 698971002398 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698971002399 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698971002400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698971002401 dimer interface [polypeptide binding]; other site 698971002402 conserved gate region; other site 698971002403 ABC-ATPase subunit interface; other site 698971002404 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698971002405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698971002406 dimer interface [polypeptide binding]; other site 698971002407 conserved gate region; other site 698971002408 putative PBP binding loops; other site 698971002409 ABC-ATPase subunit interface; other site 698971002410 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698971002411 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698971002412 Walker A/P-loop; other site 698971002413 ATP binding site [chemical binding]; other site 698971002414 Q-loop/lid; other site 698971002415 ABC transporter signature motif; other site 698971002416 Walker B; other site 698971002417 D-loop; other site 698971002418 H-loop/switch region; other site 698971002419 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698971002420 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698971002421 Walker A/P-loop; other site 698971002422 ATP binding site [chemical binding]; other site 698971002423 Q-loop/lid; other site 698971002424 ABC transporter signature motif; other site 698971002425 Walker B; other site 698971002426 D-loop; other site 698971002427 H-loop/switch region; other site 698971002428 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698971002429 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698971002430 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698971002431 Walker A/P-loop; other site 698971002432 ATP binding site [chemical binding]; other site 698971002433 ABC transporter signature motif; other site 698971002434 Walker B; other site 698971002435 D-loop; other site 698971002436 H-loop/switch region; other site 698971002437 Trypsin; Region: Trypsin; pfam00089 698971002438 active site 698971002439 substrate binding sites [chemical binding]; other site 698971002440 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 698971002441 ArsC family; Region: ArsC; pfam03960 698971002442 catalytic residues [active] 698971002443 Protein of unknown function (DUF402); Region: DUF402; cl00979 698971002444 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 698971002445 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 698971002446 G1 box; other site 698971002447 GTP/Mg2+ binding site [chemical binding]; other site 698971002448 G2 box; other site 698971002449 Switch I region; other site 698971002450 G3 box; other site 698971002451 Switch II region; other site 698971002452 G4 box; other site 698971002453 G5 box; other site 698971002454 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 698971002455 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 698971002456 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 698971002457 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698971002458 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 698971002459 Ferredoxin [Energy production and conversion]; Region: COG1146 698971002460 4Fe-4S binding domain; Region: Fer4; pfam00037 698971002461 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 698971002462 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698971002463 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698971002464 homodimer interface [polypeptide binding]; other site 698971002465 catalytic residue [active] 698971002466 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 698971002467 active site 698971002468 Predicted membrane protein [Function unknown]; Region: COG2246 698971002469 GtrA-like protein; Region: GtrA; pfam04138 698971002470 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698971002471 active site 698971002472 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 698971002473 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 698971002474 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 698971002475 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 698971002476 putative trimer interface [polypeptide binding]; other site 698971002477 putative CoA binding site [chemical binding]; other site 698971002478 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 698971002479 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 698971002480 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536 698971002481 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698971002482 putative trimer interface [polypeptide binding]; other site 698971002483 putative CoA binding site [chemical binding]; other site 698971002484 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 698971002485 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 698971002486 metal binding site [ion binding]; metal-binding site 698971002487 putative dimer interface [polypeptide binding]; other site 698971002488 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 698971002489 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 698971002490 dihydropteroate synthase; Region: DHPS; TIGR01496 698971002491 substrate binding pocket [chemical binding]; other site 698971002492 dimer interface [polypeptide binding]; other site 698971002493 inhibitor binding site; inhibition site 698971002494 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 698971002495 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 698971002496 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 698971002497 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698971002498 S-adenosylmethionine binding site [chemical binding]; other site 698971002499 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 698971002500 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 698971002501 active site 698971002502 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 698971002503 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 698971002504 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 698971002505 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698971002506 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 698971002507 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 698971002508 ligand binding site; other site 698971002509 oligomer interface; other site 698971002510 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 698971002511 dimer interface [polypeptide binding]; other site 698971002512 N-terminal domain interface [polypeptide binding]; other site 698971002513 sulfate 1 binding site; other site 698971002514 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 698971002515 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698971002516 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 698971002517 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698971002518 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698971002519 DNA binding residues [nucleotide binding] 698971002520 Putative zinc-finger; Region: zf-HC2; pfam13490 698971002521 sec-independent translocase; Provisional; Region: tatB; PRK00182 698971002522 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 698971002523 Domain of unknown function DUF59; Region: DUF59; pfam01883 698971002524 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 698971002525 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 698971002526 Predicted membrane protein [Function unknown]; Region: COG4420 698971002527 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 698971002528 MgtE intracellular N domain; Region: MgtE_N; smart00924 698971002529 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 698971002530 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 698971002531 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 698971002532 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 698971002533 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 698971002534 TPP-binding site [chemical binding]; other site 698971002535 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 698971002536 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698971002537 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698971002538 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698971002539 Walker A/P-loop; other site 698971002540 ATP binding site [chemical binding]; other site 698971002541 Q-loop/lid; other site 698971002542 ABC transporter signature motif; other site 698971002543 Walker B; other site 698971002544 D-loop; other site 698971002545 H-loop/switch region; other site 698971002546 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698971002547 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698971002548 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698971002549 Walker A/P-loop; other site 698971002550 ATP binding site [chemical binding]; other site 698971002551 Q-loop/lid; other site 698971002552 ABC transporter signature motif; other site 698971002553 Walker B; other site 698971002554 D-loop; other site 698971002555 H-loop/switch region; other site 698971002556 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 698971002557 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 698971002558 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 698971002559 shikimate binding site; other site 698971002560 NAD(P) binding site [chemical binding]; other site 698971002561 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 698971002562 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 698971002563 substrate binding pocket [chemical binding]; other site 698971002564 catalytic triad [active] 698971002565 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 698971002566 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 698971002567 active site 698971002568 catalytic residues [active] 698971002569 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 698971002570 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 698971002571 Na binding site [ion binding]; other site 698971002572 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 698971002573 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 698971002574 nucleotide binding site/active site [active] 698971002575 HIT family signature motif; other site 698971002576 catalytic residue [active] 698971002577 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 698971002578 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 698971002579 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 698971002580 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 698971002581 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 698971002582 PLD-like domain; Region: PLDc_2; pfam13091 698971002583 putative homodimer interface [polypeptide binding]; other site 698971002584 putative active site [active] 698971002585 catalytic site [active] 698971002586 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698971002587 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698971002588 putative Mg++ binding site [ion binding]; other site 698971002589 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698971002590 nucleotide binding region [chemical binding]; other site 698971002591 ATP-binding site [chemical binding]; other site 698971002592 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 698971002593 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 698971002594 active site 698971002595 8-oxo-dGMP binding site [chemical binding]; other site 698971002596 nudix motif; other site 698971002597 metal binding site [ion binding]; metal-binding site 698971002598 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 698971002599 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698971002600 ATP binding site [chemical binding]; other site 698971002601 Mg++ binding site [ion binding]; other site 698971002602 motif III; other site 698971002603 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698971002604 nucleotide binding region [chemical binding]; other site 698971002605 ATP-binding site [chemical binding]; other site 698971002606 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 698971002607 putative RNA binding site [nucleotide binding]; other site 698971002608 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 698971002609 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 698971002610 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 698971002611 Na binding site [ion binding]; other site 698971002612 SNF2 Helicase protein; Region: DUF3670; pfam12419 698971002613 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 698971002614 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698971002615 ATP binding site [chemical binding]; other site 698971002616 putative Mg++ binding site [ion binding]; other site 698971002617 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698971002618 nucleotide binding region [chemical binding]; other site 698971002619 ATP-binding site [chemical binding]; other site 698971002620 Uncharacterized conserved protein [Function unknown]; Region: COG4279 698971002621 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 698971002622 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 698971002623 active site 698971002624 metal binding site [ion binding]; metal-binding site 698971002625 DNA binding site [nucleotide binding] 698971002626 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 698971002627 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698971002628 Walker A/P-loop; other site 698971002629 ATP binding site [chemical binding]; other site 698971002630 Q-loop/lid; other site 698971002631 Uncharacterized conserved protein [Function unknown]; Region: COG2353 698971002632 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698971002633 MarR family; Region: MarR_2; pfam12802 698971002634 PspC domain; Region: PspC; cl00864 698971002635 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 698971002636 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 698971002637 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 698971002638 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 698971002639 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 698971002640 Cysteine-rich domain; Region: CCG; pfam02754 698971002641 Cysteine-rich domain; Region: CCG; pfam02754 698971002642 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 698971002643 L-lactate permease; Region: Lactate_perm; cl00701 698971002644 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 698971002645 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 698971002646 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 698971002647 active site 698971002648 HIGH motif; other site 698971002649 KMSK motif region; other site 698971002650 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 698971002651 tRNA binding surface [nucleotide binding]; other site 698971002652 anticodon binding site; other site 698971002653 diaminopimelate decarboxylase; Region: lysA; TIGR01048 698971002654 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 698971002655 active site 698971002656 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698971002657 substrate binding site [chemical binding]; other site 698971002658 catalytic residues [active] 698971002659 dimer interface [polypeptide binding]; other site 698971002660 homoserine dehydrogenase; Provisional; Region: PRK06349 698971002661 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 698971002662 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 698971002663 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 698971002664 homoserine kinase; Provisional; Region: PRK01212 698971002665 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620 698971002666 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698971002667 acyl-activating enzyme (AAE) consensus motif; other site 698971002668 AMP binding site [chemical binding]; other site 698971002669 active site 698971002670 CoA binding site [chemical binding]; other site 698971002671 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 698971002672 transcription termination factor Rho; Provisional; Region: PRK12608 698971002673 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698971002674 RNA binding site [nucleotide binding]; other site 698971002675 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 698971002676 multimer interface [polypeptide binding]; other site 698971002677 Walker A motif; other site 698971002678 ATP binding site [chemical binding]; other site 698971002679 Walker B motif; other site 698971002680 peptide chain release factor 1; Validated; Region: prfA; PRK00591 698971002681 This domain is found in peptide chain release factors; Region: PCRF; smart00937 698971002682 RF-1 domain; Region: RF-1; pfam00472 698971002683 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 698971002684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698971002685 S-adenosylmethionine binding site [chemical binding]; other site 698971002686 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 698971002687 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 698971002688 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 698971002689 Mg++ binding site [ion binding]; other site 698971002690 putative catalytic motif [active] 698971002691 substrate binding site [chemical binding]; other site 698971002692 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 698971002693 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 698971002694 F0F1 ATP synthase subunit C; Validated; Region: PRK07874 698971002695 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 698971002696 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 698971002697 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 698971002698 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 698971002699 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 698971002700 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 698971002701 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 698971002702 beta subunit interaction interface [polypeptide binding]; other site 698971002703 Walker A motif; other site 698971002704 ATP binding site [chemical binding]; other site 698971002705 Walker B motif; other site 698971002706 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698971002707 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 698971002708 core domain interface [polypeptide binding]; other site 698971002709 delta subunit interface [polypeptide binding]; other site 698971002710 epsilon subunit interface [polypeptide binding]; other site 698971002711 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 698971002712 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 698971002713 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 698971002714 alpha subunit interaction interface [polypeptide binding]; other site 698971002715 Walker A motif; other site 698971002716 ATP binding site [chemical binding]; other site 698971002717 Walker B motif; other site 698971002718 inhibitor binding site; inhibition site 698971002719 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698971002720 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 698971002721 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 698971002722 gamma subunit interface [polypeptide binding]; other site 698971002723 epsilon subunit interface [polypeptide binding]; other site 698971002724 LBP interface [polypeptide binding]; other site 698971002725 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 698971002726 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 698971002727 hypothetical protein; Provisional; Region: PRK03298 698971002728 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 698971002729 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698971002730 dimer interface [polypeptide binding]; other site 698971002731 substrate binding site [chemical binding]; other site 698971002732 metal binding site [ion binding]; metal-binding site 698971002733 Domain of unknown function DUF77; Region: DUF77; pfam01910 698971002734 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698971002735 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698971002736 Walker A/P-loop; other site 698971002737 ATP binding site [chemical binding]; other site 698971002738 Q-loop/lid; other site 698971002739 ABC transporter signature motif; other site 698971002740 Walker B; other site 698971002741 D-loop; other site 698971002742 H-loop/switch region; other site 698971002743 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698971002744 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698971002745 ABC-ATPase subunit interface; other site 698971002746 dimer interface [polypeptide binding]; other site 698971002747 putative PBP binding regions; other site 698971002748 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698971002749 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698971002750 ABC-ATPase subunit interface; other site 698971002751 dimer interface [polypeptide binding]; other site 698971002752 putative PBP binding regions; other site 698971002753 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 698971002754 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698971002755 siderophore binding site; other site 698971002756 TIGR02611 family protein; Region: TIGR02611 698971002757 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 698971002758 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 698971002759 glycogen branching enzyme; Provisional; Region: PRK05402 698971002760 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 698971002761 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 698971002762 active site 698971002763 catalytic site [active] 698971002764 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 698971002765 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 698971002766 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 698971002767 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698971002768 active site 698971002769 homodimer interface [polypeptide binding]; other site 698971002770 catalytic site [active] 698971002771 acceptor binding site [chemical binding]; other site 698971002772 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698971002773 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698971002774 Walker A/P-loop; other site 698971002775 ATP binding site [chemical binding]; other site 698971002776 Q-loop/lid; other site 698971002777 ABC transporter signature motif; other site 698971002778 Walker B; other site 698971002779 D-loop; other site 698971002780 H-loop/switch region; other site 698971002781 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 698971002782 Ligand binding site [chemical binding]; other site 698971002783 Electron transfer flavoprotein domain; Region: ETF; pfam01012 698971002784 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 698971002785 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 698971002786 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 698971002787 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 698971002788 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 698971002789 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698971002790 catalytic residue [active] 698971002791 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698971002792 S-adenosylmethionine binding site [chemical binding]; other site 698971002793 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 698971002794 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 698971002795 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 698971002796 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 698971002797 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698971002798 active site 698971002799 catalytic site [active] 698971002800 substrate binding site [chemical binding]; other site 698971002801 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 698971002802 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 698971002803 nucleotide binding pocket [chemical binding]; other site 698971002804 K-X-D-G motif; other site 698971002805 catalytic site [active] 698971002806 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 698971002807 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 698971002808 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 698971002809 Dimer interface [polypeptide binding]; other site 698971002810 BRCT sequence motif; other site 698971002811 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 698971002812 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 698971002813 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 698971002814 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 698971002815 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 698971002816 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698971002817 Coenzyme A binding pocket [chemical binding]; other site 698971002818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698971002819 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698971002820 putative substrate translocation pore; other site 698971002821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698971002822 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698971002823 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698971002824 ABC-ATPase subunit interface; other site 698971002825 dimer interface [polypeptide binding]; other site 698971002826 putative PBP binding regions; other site 698971002827 proposed F420-0 ABC transporter, ATP-binding protein; Region: F420-0_ABC_ATP; TIGR03873 698971002828 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698971002829 Walker A/P-loop; other site 698971002830 ATP binding site [chemical binding]; other site 698971002831 Q-loop/lid; other site 698971002832 ABC transporter signature motif; other site 698971002833 Walker B; other site 698971002834 D-loop; other site 698971002835 H-loop/switch region; other site 698971002836 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 698971002837 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 698971002838 putative ligand binding residues [chemical binding]; other site 698971002839 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 698971002840 phosphofructokinase; Region: PFK_mixed; TIGR02483 698971002841 active site 698971002842 ADP/pyrophosphate binding site [chemical binding]; other site 698971002843 dimerization interface [polypeptide binding]; other site 698971002844 allosteric effector site; other site 698971002845 fructose-1,6-bisphosphate binding site; other site 698971002846 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 698971002847 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 698971002848 GatB domain; Region: GatB_Yqey; smart00845 698971002849 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698971002850 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698971002851 active site 698971002852 catalytic tetrad [active] 698971002853 Lysine efflux permease [General function prediction only]; Region: COG1279 698971002854 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 698971002855 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698971002856 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698971002857 dimerization interface [polypeptide binding]; other site 698971002858 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 698971002859 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 698971002860 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 698971002861 putative dimer interface [polypeptide binding]; other site 698971002862 N-terminal domain interface [polypeptide binding]; other site 698971002863 putative substrate binding pocket (H-site) [chemical binding]; other site 698971002864 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 698971002865 Predicted membrane protein [Function unknown]; Region: COG2259 698971002866 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 698971002867 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 698971002868 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 698971002869 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 698971002870 PYR/PP interface [polypeptide binding]; other site 698971002871 dimer interface [polypeptide binding]; other site 698971002872 TPP binding site [chemical binding]; other site 698971002873 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698971002874 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 698971002875 TPP-binding site [chemical binding]; other site 698971002876 dimer interface [polypeptide binding]; other site 698971002877 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 698971002878 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 698971002879 putative valine binding site [chemical binding]; other site 698971002880 dimer interface [polypeptide binding]; other site 698971002881 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 698971002882 ketol-acid reductoisomerase; Provisional; Region: PRK05479 698971002883 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 698971002884 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 698971002885 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 698971002886 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 698971002887 Uncharacterized conserved protein [Function unknown]; Region: COG1479 698971002888 Protein of unknown function DUF262; Region: DUF262; pfam03235 698971002889 Uncharacterized conserved protein [Function unknown]; Region: COG3472 698971002890 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 698971002891 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 698971002892 ligand binding site [chemical binding]; other site 698971002893 NAD binding site [chemical binding]; other site 698971002894 dimerization interface [polypeptide binding]; other site 698971002895 catalytic site [active] 698971002896 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 698971002897 putative L-serine binding site [chemical binding]; other site 698971002898 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 698971002899 tartrate dehydrogenase; Region: TTC; TIGR02089 698971002900 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698971002901 ligand binding site [chemical binding]; other site 698971002902 flexible hinge region; other site 698971002903 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 698971002904 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 698971002905 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698971002906 metal binding triad; other site 698971002907 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 698971002908 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 698971002909 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 698971002910 catalytic site [active] 698971002911 Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115 698971002912 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 698971002913 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 698971002914 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 698971002915 Methyltransferase domain; Region: Methyltransf_23; pfam13489 698971002916 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698971002917 S-adenosylmethionine binding site [chemical binding]; other site 698971002918 isochorismate synthase DhbC; Validated; Region: PRK06923 698971002919 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698971002920 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 698971002921 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 698971002922 active site 698971002923 HIGH motif; other site 698971002924 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 698971002925 active site 698971002926 KMSKS motif; other site 698971002927 Predicted esterase [General function prediction only]; Region: COG0400 698971002928 MMPL family; Region: MMPL; pfam03176 698971002929 Ethanolamine utilisation protein, EutH; Region: EutH; cl01248 698971002930 Cutinase; Region: Cutinase; pfam01083 698971002931 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 698971002932 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 698971002933 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 698971002934 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 698971002935 PhnA protein; Region: PhnA; pfam03831 698971002936 biotin synthase; Region: bioB; TIGR00433 698971002937 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698971002938 FeS/SAM binding site; other site 698971002939 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 698971002940 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 698971002941 HD domain; Region: HD_4; pfam13328 698971002942 Transcriptional regulator [Transcription]; Region: IclR; COG1414 698971002943 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698971002944 putative DNA binding site [nucleotide binding]; other site 698971002945 putative Zn2+ binding site [ion binding]; other site 698971002946 Bacterial transcriptional regulator; Region: IclR; pfam01614 698971002947 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 698971002948 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 698971002949 substrate binding site [chemical binding]; other site 698971002950 ligand binding site [chemical binding]; other site 698971002951 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 698971002952 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 698971002953 substrate binding site [chemical binding]; other site 698971002954 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 698971002955 active site 698971002956 Ap6A binding site [chemical binding]; other site 698971002957 nudix motif; other site 698971002958 metal binding site [ion binding]; metal-binding site 698971002959 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698971002960 catalytic core [active] 698971002961 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 698971002962 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 698971002963 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 698971002964 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 698971002965 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 698971002966 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698971002967 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 698971002968 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 698971002969 thiamine monophosphate kinase; Provisional; Region: PRK05731 698971002970 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 698971002971 ATP binding site [chemical binding]; other site 698971002972 dimerization interface [polypeptide binding]; other site 698971002973 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 698971002974 ligand binding site [chemical binding]; other site 698971002975 active site 698971002976 UGI interface [polypeptide binding]; other site 698971002977 catalytic site [active] 698971002978 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 698971002979 DAK2 domain; Region: Dak2; pfam02734 698971002980 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 698971002981 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 698971002982 generic binding surface II; other site 698971002983 ssDNA binding site; other site 698971002984 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698971002985 ATP binding site [chemical binding]; other site 698971002986 putative Mg++ binding site [ion binding]; other site 698971002987 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698971002988 nucleotide binding region [chemical binding]; other site 698971002989 ATP-binding site [chemical binding]; other site 698971002990 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698971002991 carboxyltransferase (CT) interaction site; other site 698971002992 biotinylation site [posttranslational modification]; other site 698971002993 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 698971002994 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698971002995 S-adenosylmethionine binding site [chemical binding]; other site 698971002996 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 698971002997 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 698971002998 active site 698971002999 (T/H)XGH motif; other site 698971003000 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 698971003001 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698971003002 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698971003003 Walker A/P-loop; other site 698971003004 ATP binding site [chemical binding]; other site 698971003005 Q-loop/lid; other site 698971003006 ABC transporter signature motif; other site 698971003007 Walker B; other site 698971003008 D-loop; other site 698971003009 H-loop/switch region; other site 698971003010 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698971003011 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698971003012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698971003013 dimer interface [polypeptide binding]; other site 698971003014 conserved gate region; other site 698971003015 putative PBP binding loops; other site 698971003016 ABC-ATPase subunit interface; other site 698971003017 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698971003018 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698971003019 substrate binding pocket [chemical binding]; other site 698971003020 membrane-bound complex binding site; other site 698971003021 hinge residues; other site 698971003022 Domain of unknown function (DUF368); Region: DUF368; pfam04018 698971003023 DNA polymerase I; Provisional; Region: PRK05755 698971003024 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 698971003025 active site 698971003026 metal binding site 1 [ion binding]; metal-binding site 698971003027 putative 5' ssDNA interaction site; other site 698971003028 metal binding site 3; metal-binding site 698971003029 metal binding site 2 [ion binding]; metal-binding site 698971003030 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 698971003031 putative DNA binding site [nucleotide binding]; other site 698971003032 putative metal binding site [ion binding]; other site 698971003033 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 698971003034 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 698971003035 active site 698971003036 DNA binding site [nucleotide binding] 698971003037 catalytic site [active] 698971003038 Methyltransferase domain; Region: Methyltransf_23; pfam13489 698971003039 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698971003040 S-adenosylmethionine binding site [chemical binding]; other site 698971003041 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 698971003042 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 698971003043 RNA binding site [nucleotide binding]; other site 698971003044 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 698971003045 RNA binding site [nucleotide binding]; other site 698971003046 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698971003047 RNA binding site [nucleotide binding]; other site 698971003048 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 698971003049 RNA binding site [nucleotide binding]; other site 698971003050 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 698971003051 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 698971003052 transcriptional antiterminator BglG; Provisional; Region: PRK09772 698971003053 CAT RNA binding domain; Region: CAT_RBD; smart01061 698971003054 PRD domain; Region: PRD; pfam00874 698971003055 PRD domain; Region: PRD; pfam00874 698971003056 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 698971003057 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 698971003058 active site turn [active] 698971003059 phosphorylation site [posttranslational modification] 698971003060 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 698971003061 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 698971003062 HPr interaction site; other site 698971003063 glycerol kinase (GK) interaction site [polypeptide binding]; other site 698971003064 active site 698971003065 phosphorylation site [posttranslational modification] 698971003066 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 698971003067 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 698971003068 CoA-binding site [chemical binding]; other site 698971003069 ATP-binding [chemical binding]; other site 698971003070 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 698971003071 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698971003072 FeS/SAM binding site; other site 698971003073 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 698971003074 excinuclease ABC subunit B; Provisional; Region: PRK05298 698971003075 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698971003076 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698971003077 nucleotide binding region [chemical binding]; other site 698971003078 ATP-binding site [chemical binding]; other site 698971003079 Ultra-violet resistance protein B; Region: UvrB; pfam12344 698971003080 UvrB/uvrC motif; Region: UVR; pfam02151 698971003081 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698971003082 Ligand Binding Site [chemical binding]; other site 698971003083 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 698971003084 Part of AAA domain; Region: AAA_19; pfam13245 698971003085 PhoH-like protein; Region: PhoH; cl17668 698971003086 Family description; Region: UvrD_C_2; pfam13538 698971003087 Predicted membrane protein [Function unknown]; Region: COG2259 698971003088 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698971003089 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 698971003090 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698971003091 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698971003092 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 698971003093 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 698971003094 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 698971003095 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 698971003096 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 698971003097 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 698971003098 23S rRNA binding site [nucleotide binding]; other site 698971003099 L21 binding site [polypeptide binding]; other site 698971003100 L13 binding site [polypeptide binding]; other site 698971003101 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698971003102 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 698971003103 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698971003104 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 698971003105 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 698971003106 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 698971003107 dimer interface [polypeptide binding]; other site 698971003108 motif 1; other site 698971003109 active site 698971003110 motif 2; other site 698971003111 motif 3; other site 698971003112 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 698971003113 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 698971003114 putative tRNA-binding site [nucleotide binding]; other site 698971003115 B3/4 domain; Region: B3_4; pfam03483 698971003116 tRNA synthetase B5 domain; Region: B5; smart00874 698971003117 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 698971003118 dimer interface [polypeptide binding]; other site 698971003119 motif 1; other site 698971003120 motif 3; other site 698971003121 motif 2; other site 698971003122 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 698971003123 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 698971003124 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 698971003125 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 698971003126 heterotetramer interface [polypeptide binding]; other site 698971003127 active site pocket [active] 698971003128 cleavage site 698971003129 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 698971003130 feedback inhibition sensing region; other site 698971003131 homohexameric interface [polypeptide binding]; other site 698971003132 nucleotide binding site [chemical binding]; other site 698971003133 N-acetyl-L-glutamate binding site [chemical binding]; other site 698971003134 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 698971003135 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698971003136 inhibitor-cofactor binding pocket; inhibition site 698971003137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698971003138 catalytic residue [active] 698971003139 ornithine carbamoyltransferase; Provisional; Region: PRK00779 698971003140 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 698971003141 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 698971003142 arginine repressor; Provisional; Region: PRK03341 698971003143 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 698971003144 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 698971003145 argininosuccinate synthase; Provisional; Region: PRK13820 698971003146 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 698971003147 ANP binding site [chemical binding]; other site 698971003148 Substrate Binding Site II [chemical binding]; other site 698971003149 Substrate Binding Site I [chemical binding]; other site 698971003150 argininosuccinate lyase; Provisional; Region: PRK00855 698971003151 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 698971003152 active sites [active] 698971003153 tetramer interface [polypeptide binding]; other site 698971003154 Uncharacterized conserved protein [Function unknown]; Region: COG2835 698971003155 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 698971003156 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 698971003157 active site 698971003158 HIGH motif; other site 698971003159 dimer interface [polypeptide binding]; other site 698971003160 KMSKS motif; other site 698971003161 S4 RNA-binding domain; Region: S4; smart00363 698971003162 transcription termination factor Rho; Provisional; Region: PRK12678 698971003163 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 698971003164 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 698971003165 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698971003166 active site 698971003167 motif I; other site 698971003168 motif II; other site 698971003169 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698971003170 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 698971003171 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698971003172 RNA binding surface [nucleotide binding]; other site 698971003173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698971003174 S-adenosylmethionine binding site [chemical binding]; other site 698971003175 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 698971003176 ATP-NAD kinase; Region: NAD_kinase; pfam01513 698971003177 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 698971003178 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 698971003179 Walker A/P-loop; other site 698971003180 ATP binding site [chemical binding]; other site 698971003181 Q-loop/lid; other site 698971003182 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 698971003183 ABC transporter signature motif; other site 698971003184 Walker B; other site 698971003185 D-loop; other site 698971003186 H-loop/switch region; other site 698971003187 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 698971003188 Thiamine pyrophosphokinase; Region: TPK; cl08415 698971003189 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 698971003190 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 698971003191 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 698971003192 dimer interface [polypeptide binding]; other site 698971003193 ADP-ribose binding site [chemical binding]; other site 698971003194 active site 698971003195 nudix motif; other site 698971003196 metal binding site [ion binding]; metal-binding site 698971003197 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 698971003198 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 698971003199 active site 698971003200 Int/Topo IB signature motif; other site 698971003201 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 698971003202 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698971003203 P-loop; other site 698971003204 Magnesium ion binding site [ion binding]; other site 698971003205 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698971003206 Magnesium ion binding site [ion binding]; other site 698971003207 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 698971003208 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 698971003209 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 698971003210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698971003211 POT family; Region: PTR2; cl17359 698971003212 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05630 698971003213 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698971003214 inhibitor-cofactor binding pocket; inhibition site 698971003215 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698971003216 catalytic residue [active] 698971003217 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 698971003218 AAA domain; Region: AAA_26; pfam13500 698971003219 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 698971003220 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 698971003221 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 698971003222 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698971003223 RNA binding surface [nucleotide binding]; other site 698971003224 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 698971003225 active site 698971003226 cytidylate kinase; Provisional; Region: cmk; PRK00023 698971003227 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 698971003228 CMP-binding site; other site 698971003229 The sites determining sugar specificity; other site 698971003230 GTP-binding protein Der; Reviewed; Region: PRK03003 698971003231 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 698971003232 G1 box; other site 698971003233 GTP/Mg2+ binding site [chemical binding]; other site 698971003234 Switch I region; other site 698971003235 G2 box; other site 698971003236 Switch II region; other site 698971003237 G3 box; other site 698971003238 G4 box; other site 698971003239 G5 box; other site 698971003240 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 698971003241 G1 box; other site 698971003242 GTP/Mg2+ binding site [chemical binding]; other site 698971003243 Switch I region; other site 698971003244 G2 box; other site 698971003245 G3 box; other site 698971003246 Switch II region; other site 698971003247 G4 box; other site 698971003248 G5 box; other site 698971003249 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 698971003250 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 698971003251 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698971003252 S-adenosylmethionine binding site [chemical binding]; other site 698971003253 Putative esterase; Region: Esterase; pfam00756 698971003254 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698971003255 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 698971003256 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698971003257 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 698971003258 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698971003259 nucleotide binding region [chemical binding]; other site 698971003260 ATP-binding site [chemical binding]; other site 698971003261 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 698971003262 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 698971003263 phosphopeptide binding site; other site 698971003264 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 698971003265 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698971003266 DNA binding residues [nucleotide binding] 698971003267 Bifunctional nuclease; Region: DNase-RNase; pfam02577 698971003268 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 698971003269 DNA binding residues [nucleotide binding] 698971003270 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698971003271 putative dimer interface [polypeptide binding]; other site 698971003272 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698971003273 metal ion-dependent adhesion site (MIDAS); other site 698971003274 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698971003275 Domain of unknown function DUF21; Region: DUF21; pfam01595 698971003276 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698971003277 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698971003278 Domain of unknown function DUF21; Region: DUF21; pfam01595 698971003279 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698971003280 Transporter associated domain; Region: CorC_HlyC; smart01091 698971003281 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 698971003282 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698971003283 ATP binding site [chemical binding]; other site 698971003284 Mg++ binding site [ion binding]; other site 698971003285 motif III; other site 698971003286 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698971003287 nucleotide binding region [chemical binding]; other site 698971003288 ATP-binding site [chemical binding]; other site 698971003289 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 698971003290 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 698971003291 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 698971003292 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 698971003293 CoenzymeA binding site [chemical binding]; other site 698971003294 subunit interaction site [polypeptide binding]; other site 698971003295 PHB binding site; other site 698971003296 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 698971003297 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 698971003298 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 698971003299 oligomer interface [polypeptide binding]; other site 698971003300 metal binding site [ion binding]; metal-binding site 698971003301 metal binding site [ion binding]; metal-binding site 698971003302 putative Cl binding site [ion binding]; other site 698971003303 basic sphincter; other site 698971003304 hydrophobic gate; other site 698971003305 periplasmic entrance; other site 698971003306 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698971003307 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698971003308 S-adenosylmethionine binding site [chemical binding]; other site 698971003309 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 698971003310 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698971003311 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698971003312 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 698971003313 potential frameshift: common BLAST hit: gi|337290692|ref|YP_004629713.1| putative RNA helicase 698971003314 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 698971003315 potential frameshift: common BLAST hit: gi|337290692|ref|YP_004629713.1| putative RNA helicase 698971003316 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 698971003317 FAD binding domain; Region: FAD_binding_4; pfam01565 698971003318 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 698971003319 Sodium Bile acid symporter family; Region: SBF; pfam01758 698971003320 YceI-like domain; Region: YceI; pfam04264 698971003321 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 698971003322 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 698971003323 Ligand binding site; other site 698971003324 Putative Catalytic site; other site 698971003325 DXD motif; other site 698971003326 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 698971003327 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 698971003328 putative active site [active] 698971003329 catalytic triad [active] 698971003330 putative dimer interface [polypeptide binding]; other site 698971003331 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 698971003332 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 698971003333 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 698971003334 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 698971003335 precorrin-3B synthase; Region: CobG; TIGR02435 698971003336 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698971003337 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698971003338 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 698971003339 Precorrin-8X methylmutase; Region: CbiC; pfam02570 698971003340 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 698971003341 active site 698971003342 SAM binding site [chemical binding]; other site 698971003343 homodimer interface [polypeptide binding]; other site 698971003344 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 698971003345 active site 698971003346 SAM binding site [chemical binding]; other site 698971003347 homodimer interface [polypeptide binding]; other site 698971003348 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 698971003349 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 698971003350 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 698971003351 active site 698971003352 SAM binding site [chemical binding]; other site 698971003353 homodimer interface [polypeptide binding]; other site 698971003354 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 698971003355 active site 698971003356 putative homodimer interface [polypeptide binding]; other site 698971003357 SAM binding site [chemical binding]; other site 698971003358 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 698971003359 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698971003360 S-adenosylmethionine binding site [chemical binding]; other site 698971003361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698971003362 short chain dehydrogenase; Provisional; Region: PRK08251 698971003363 NAD(P) binding site [chemical binding]; other site 698971003364 active site 698971003365 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698971003366 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698971003367 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 698971003368 active site 698971003369 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698971003370 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698971003371 ATP binding site [chemical binding]; other site 698971003372 putative Mg++ binding site [ion binding]; other site 698971003373 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698971003374 nucleotide binding region [chemical binding]; other site 698971003375 ATP-binding site [chemical binding]; other site 698971003376 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 698971003377 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 698971003378 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 698971003379 twin arginine translocase protein A; Provisional; Region: tatA; PRK00191 698971003380 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 698971003381 Predicted transcriptional regulator [Transcription]; Region: COG2378 698971003382 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 698971003383 WYL domain; Region: WYL; pfam13280 698971003384 WYL domain; Region: WYL; pfam13280 698971003385 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 698971003386 Pup-like protein; Region: Pup; pfam05639 698971003387 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 698971003388 proteasome ATPase; Region: pup_AAA; TIGR03689 698971003389 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698971003390 Walker A motif; other site 698971003391 ATP binding site [chemical binding]; other site 698971003392 Walker B motif; other site 698971003393 arginine finger; other site 698971003394 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 698971003395 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698971003396 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 698971003397 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 698971003398 active site 698971003399 metal binding site [ion binding]; metal-binding site 698971003400 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 698971003401 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 698971003402 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 698971003403 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 698971003404 Potassium binding sites [ion binding]; other site 698971003405 Cesium cation binding sites [ion binding]; other site 698971003406 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 698971003407 Aspartase; Region: Aspartase; cd01357 698971003408 active sites [active] 698971003409 tetramer interface [polypeptide binding]; other site 698971003410 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 698971003411 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 698971003412 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 698971003413 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 698971003414 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 698971003415 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 698971003416 homodimer interface [polypeptide binding]; other site 698971003417 putative metal binding site [ion binding]; other site 698971003418 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 698971003419 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698971003420 motif II; other site 698971003421 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 698971003422 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 698971003423 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 698971003424 substrate binding pocket [chemical binding]; other site 698971003425 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 698971003426 B12 binding site [chemical binding]; other site 698971003427 cobalt ligand [ion binding]; other site 698971003428 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 698971003429 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 698971003430 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698971003431 active site 698971003432 HIGH motif; other site 698971003433 nucleotide binding site [chemical binding]; other site 698971003434 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698971003435 active site 698971003436 KMSKS motif; other site 698971003437 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 698971003438 tRNA binding surface [nucleotide binding]; other site 698971003439 anticodon binding site; other site 698971003440 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 698971003441 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 698971003442 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 698971003443 quinone interaction residues [chemical binding]; other site 698971003444 active site 698971003445 catalytic residues [active] 698971003446 FMN binding site [chemical binding]; other site 698971003447 substrate binding site [chemical binding]; other site 698971003448 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 698971003449 substrate binding site [chemical binding]; other site 698971003450 potential frameshift: common BLAST hit: gi|38233440|ref|NP_939207.1| transposase 698971003451 Integrase core domain; Region: rve_2; pfam13333 698971003452 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698971003453 HTH-like domain; Region: HTH_21; pfam13276 698971003454 Integrase core domain; Region: rve; pfam00665 698971003455 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698971003456 active site 698971003457 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698971003458 active site residue [active] 698971003459 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 698971003460 active site residue [active] 698971003461 membrane ATPase/protein kinase; Provisional; Region: PRK09435 698971003462 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 698971003463 Walker A; other site 698971003464 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 698971003465 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 698971003466 active site 698971003467 substrate binding site [chemical binding]; other site 698971003468 coenzyme B12 binding site [chemical binding]; other site 698971003469 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 698971003470 B12 binding site [chemical binding]; other site 698971003471 cobalt ligand [ion binding]; other site 698971003472 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 698971003473 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 698971003474 heterodimer interface [polypeptide binding]; other site 698971003475 substrate interaction site [chemical binding]; other site 698971003476 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 698971003477 Uncharacterized conserved protein [Function unknown]; Region: COG0398 698971003478 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 698971003479 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 698971003480 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 698971003481 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 698971003482 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 698971003483 ferrochelatase; Reviewed; Region: hemH; PRK00035 698971003484 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 698971003485 C-terminal domain interface [polypeptide binding]; other site 698971003486 active site 698971003487 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 698971003488 active site 698971003489 N-terminal domain interface [polypeptide binding]; other site 698971003490 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698971003491 NlpC/P60 family; Region: NLPC_P60; pfam00877 698971003492 aconitate hydratase; Validated; Region: PRK09277 698971003493 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 698971003494 substrate binding site [chemical binding]; other site 698971003495 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 698971003496 ligand binding site [chemical binding]; other site 698971003497 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 698971003498 substrate binding site [chemical binding]; other site 698971003499 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698971003500 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698971003501 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 698971003502 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 698971003503 catalytic triad [active] 698971003504 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 698971003505 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 698971003506 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698971003507 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698971003508 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698971003509 Walker A/P-loop; other site 698971003510 ATP binding site [chemical binding]; other site 698971003511 Q-loop/lid; other site 698971003512 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698971003513 ABC transporter signature motif; other site 698971003514 Walker B; other site 698971003515 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698971003516 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 698971003517 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 698971003518 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 698971003519 trimerization site [polypeptide binding]; other site 698971003520 active site 698971003521 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 698971003522 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 698971003523 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698971003524 catalytic residue [active] 698971003525 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 698971003526 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 698971003527 Walker A/P-loop; other site 698971003528 ATP binding site [chemical binding]; other site 698971003529 Q-loop/lid; other site 698971003530 ABC transporter signature motif; other site 698971003531 Walker B; other site 698971003532 D-loop; other site 698971003533 H-loop/switch region; other site 698971003534 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 698971003535 FeS assembly protein SufD; Region: sufD; TIGR01981 698971003536 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 698971003537 FeS assembly protein SufB; Region: sufB; TIGR01980 698971003538 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698971003539 Predicted transcriptional regulator [Transcription]; Region: COG2345 698971003540 putative DNA binding site [nucleotide binding]; other site 698971003541 putative Zn2+ binding site [ion binding]; other site 698971003542 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 698971003543 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698971003544 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698971003545 Walker A/P-loop; other site 698971003546 ATP binding site [chemical binding]; other site 698971003547 Q-loop/lid; other site 698971003548 ABC transporter signature motif; other site 698971003549 Walker B; other site 698971003550 D-loop; other site 698971003551 H-loop/switch region; other site 698971003552 ABC-2 type transporter; Region: ABC2_membrane; cl17235 698971003553 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 698971003554 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 698971003555 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 698971003556 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 698971003557 UbiA prenyltransferase family; Region: UbiA; pfam01040 698971003558 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 698971003559 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 698971003560 TPP-binding site [chemical binding]; other site 698971003561 dimer interface [polypeptide binding]; other site 698971003562 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 698971003563 PYR/PP interface [polypeptide binding]; other site 698971003564 dimer interface [polypeptide binding]; other site 698971003565 TPP binding site [chemical binding]; other site 698971003566 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698971003567 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 698971003568 putative active site [active] 698971003569 transaldolase; Provisional; Region: PRK03903 698971003570 catalytic residue [active] 698971003571 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 698971003572 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 698971003573 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 698971003574 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 698971003575 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 698971003576 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 698971003577 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 698971003578 putative active site [active] 698971003579 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 698971003580 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 698971003581 triosephosphate isomerase; Provisional; Region: PRK14567 698971003582 substrate binding site [chemical binding]; other site 698971003583 dimer interface [polypeptide binding]; other site 698971003584 catalytic triad [active] 698971003585 Phosphoglycerate kinase; Region: PGK; pfam00162 698971003586 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 698971003587 substrate binding site [chemical binding]; other site 698971003588 hinge regions; other site 698971003589 ADP binding site [chemical binding]; other site 698971003590 catalytic site [active] 698971003591 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 698971003592 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 698971003593 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 698971003594 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 698971003595 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 698971003596 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 698971003597 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 698971003598 phosphate binding site [ion binding]; other site 698971003599 putative substrate binding pocket [chemical binding]; other site 698971003600 dimer interface [polypeptide binding]; other site 698971003601 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 698971003602 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 698971003603 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 698971003604 GIY-YIG motif/motif A; other site 698971003605 active site 698971003606 catalytic site [active] 698971003607 putative DNA binding site [nucleotide binding]; other site 698971003608 metal binding site [ion binding]; metal-binding site 698971003609 UvrB/uvrC motif; Region: UVR; pfam02151 698971003610 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 698971003611 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 698971003612 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 698971003613 homopentamer interface [polypeptide binding]; other site 698971003614 active site 698971003615 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 698971003616 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 698971003617 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 698971003618 dimerization interface [polypeptide binding]; other site 698971003619 active site 698971003620 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 698971003621 Lumazine binding domain; Region: Lum_binding; pfam00677 698971003622 Lumazine binding domain; Region: Lum_binding; pfam00677 698971003623 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 698971003624 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 698971003625 catalytic motif [active] 698971003626 Zn binding site [ion binding]; other site 698971003627 RibD C-terminal domain; Region: RibD_C; pfam01872 698971003628 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 698971003629 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 698971003630 substrate binding site [chemical binding]; other site 698971003631 hexamer interface [polypeptide binding]; other site 698971003632 metal binding site [ion binding]; metal-binding site 698971003633 16S rRNA methyltransferase B; Provisional; Region: PRK14902 698971003634 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 698971003635 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698971003636 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 698971003637 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 698971003638 putative active site [active] 698971003639 substrate binding site [chemical binding]; other site 698971003640 putative cosubstrate binding site; other site 698971003641 catalytic site [active] 698971003642 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 698971003643 substrate binding site [chemical binding]; other site 698971003644 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 698971003645 active site 698971003646 catalytic residues [active] 698971003647 metal binding site [ion binding]; metal-binding site 698971003648 primosome assembly protein PriA; Provisional; Region: PRK14873 698971003649 S-adenosylmethionine synthetase; Validated; Region: PRK05250 698971003650 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 698971003651 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 698971003652 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 698971003653 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 698971003654 Flavoprotein; Region: Flavoprotein; pfam02441 698971003655 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 698971003656 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 698971003657 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 698971003658 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 698971003659 catalytic site [active] 698971003660 G-X2-G-X-G-K; other site 698971003661 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 698971003662 active site 698971003663 dimer interface [polypeptide binding]; other site 698971003664 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 698971003665 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698971003666 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698971003667 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 698971003668 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698971003669 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698971003670 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 698971003671 IMP binding site; other site 698971003672 dimer interface [polypeptide binding]; other site 698971003673 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 698971003674 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 698971003675 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 698971003676 catalytic site [active] 698971003677 subunit interface [polypeptide binding]; other site 698971003678 dihydroorotase; Validated; Region: pyrC; PRK09357 698971003679 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698971003680 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 698971003681 active site 698971003682 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 698971003683 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 698971003684 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 698971003685 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 698971003686 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698971003687 active site 698971003688 hydrophobic ligand binding site; other site 698971003689 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 698971003690 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698971003691 TIGR01777 family protein; Region: yfcH 698971003692 NAD(P) binding site [chemical binding]; other site 698971003693 active site 698971003694 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 698971003695 elongation factor P; Validated; Region: PRK00529 698971003696 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 698971003697 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 698971003698 RNA binding site [nucleotide binding]; other site 698971003699 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 698971003700 RNA binding site [nucleotide binding]; other site 698971003701 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698971003702 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698971003703 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 698971003704 active site 698971003705 Dehydroquinase class II; Region: DHquinase_II; pfam01220 698971003706 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 698971003707 trimer interface [polypeptide binding]; other site 698971003708 active site 698971003709 dimer interface [polypeptide binding]; other site 698971003710 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 698971003711 active site 698971003712 dimer interface [polypeptide binding]; other site 698971003713 metal binding site [ion binding]; metal-binding site 698971003714 shikimate kinase; Reviewed; Region: aroK; PRK00131 698971003715 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 698971003716 ADP binding site [chemical binding]; other site 698971003717 magnesium binding site [ion binding]; other site 698971003718 putative shikimate binding site; other site 698971003719 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 698971003720 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 698971003721 Tetramer interface [polypeptide binding]; other site 698971003722 active site 698971003723 FMN-binding site [chemical binding]; other site 698971003724 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 698971003725 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 698971003726 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 698971003727 shikimate binding site; other site 698971003728 NAD(P) binding site [chemical binding]; other site 698971003729 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 698971003730 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 698971003731 dimerization interface [polypeptide binding]; other site 698971003732 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 698971003733 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 698971003734 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 698971003735 motif 1; other site 698971003736 active site 698971003737 motif 2; other site 698971003738 motif 3; other site 698971003739 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 698971003740 DHHA1 domain; Region: DHHA1; pfam02272 698971003741 recombination factor protein RarA; Reviewed; Region: PRK13342 698971003742 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698971003743 Walker A motif; other site 698971003744 ATP binding site [chemical binding]; other site 698971003745 Walker B motif; other site 698971003746 arginine finger; other site 698971003747 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 698971003748 Phosphotransferase enzyme family; Region: APH; pfam01636 698971003749 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 698971003750 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 698971003751 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 698971003752 dimer interface [polypeptide binding]; other site 698971003753 anticodon binding site; other site 698971003754 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 698971003755 homodimer interface [polypeptide binding]; other site 698971003756 motif 1; other site 698971003757 active site 698971003758 motif 2; other site 698971003759 GAD domain; Region: GAD; pfam02938 698971003760 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698971003761 active site 698971003762 motif 3; other site 698971003763 Predicted metalloprotease [General function prediction only]; Region: COG2321 698971003764 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 698971003765 potential frameshift: common BLAST hit: gi|62390520|ref|YP_225922.1| SNF2 family DNA/RNA helicase 698971003766 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698971003767 ATP binding site [chemical binding]; other site 698971003768 putative Mg++ binding site [ion binding]; other site 698971003769 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698971003770 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 698971003771 nucleotide binding region [chemical binding]; other site 698971003772 ATP-binding site [chemical binding]; other site 698971003773 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 698971003774 Predicted membrane protein [Function unknown]; Region: COG1511 698971003775 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 698971003776 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698971003777 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698971003778 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698971003779 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 698971003780 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698971003781 Q-loop/lid; other site 698971003782 ABC transporter signature motif; other site 698971003783 Walker B; other site 698971003784 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698971003785 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698971003786 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 698971003787 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 698971003788 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 698971003789 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 698971003790 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 698971003791 dimer interface [polypeptide binding]; other site 698971003792 motif 1; other site 698971003793 active site 698971003794 motif 2; other site 698971003795 motif 3; other site 698971003796 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 698971003797 anticodon binding site; other site 698971003798 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698971003799 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 698971003800 dimer interface [polypeptide binding]; other site 698971003801 catalytic triad [active] 698971003802 peroxidatic and resolving cysteines [active] 698971003803 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 698971003804 active site 698971003805 MULE transposase domain; Region: MULE; pfam10551 698971003806 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698971003807 MULE transposase domain; Region: MULE; pfam10551 698971003808 potential frameshift: common BLAST hit: gi|38233440|ref|NP_939207.1| transposase 698971003809 Integrase core domain; Region: rve_2; pfam13333 698971003810 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698971003811 HTH-like domain; Region: HTH_21; pfam13276 698971003812 Integrase core domain; Region: rve; pfam00665 698971003813 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 698971003814 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698971003815 Zn2+ binding site [ion binding]; other site 698971003816 Mg2+ binding site [ion binding]; other site 698971003817 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 698971003818 synthetase active site [active] 698971003819 NTP binding site [chemical binding]; other site 698971003820 metal binding site [ion binding]; metal-binding site 698971003821 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 698971003822 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 698971003823 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698971003824 active site 698971003825 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 698971003826 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698971003827 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 698971003828 Protein export membrane protein; Region: SecD_SecF; cl14618 698971003829 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 698971003830 Protein export membrane protein; Region: SecD_SecF; cl14618 698971003831 Preprotein translocase subunit; Region: YajC; pfam02699 698971003832 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 698971003833 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698971003834 Walker A motif; other site 698971003835 ATP binding site [chemical binding]; other site 698971003836 Walker B motif; other site 698971003837 arginine finger; other site 698971003838 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 698971003839 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 698971003840 RuvA N terminal domain; Region: RuvA_N; pfam01330 698971003841 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 698971003842 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 698971003843 active site 698971003844 putative DNA-binding cleft [nucleotide binding]; other site 698971003845 dimer interface [polypeptide binding]; other site 698971003846 hypothetical protein; Validated; Region: PRK00110 698971003847 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 698971003848 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 698971003849 active site 698971003850 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 698971003851 catalytic triad [active] 698971003852 dimer interface [polypeptide binding]; other site 698971003853 Integrase core domain; Region: rve; pfam00665 698971003854 potential frameshift: common BLAST hit: gi|336115754|ref|YP_004570520.1| transposase 698971003855 Helix-turn-helix domain; Region: HTH_38; pfam13936 698971003856 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698971003857 Integrase core domain; Region: rve; pfam00665 698971003858 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 698971003859 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 698971003860 Nitronate monooxygenase; Region: NMO; pfam03060 698971003861 FMN binding site [chemical binding]; other site 698971003862 substrate binding site [chemical binding]; other site 698971003863 putative catalytic residue [active] 698971003864 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 698971003865 Replicase family; Region: Replicase; pfam03090 698971003866 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 698971003867 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 698971003868 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 698971003869 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 698971003870 catalytic residues [active] 698971003871 catalytic nucleophile [active] 698971003872 Presynaptic Site I dimer interface [polypeptide binding]; other site 698971003873 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 698971003874 Synaptic Flat tetramer interface [polypeptide binding]; other site 698971003875 Synaptic Site I dimer interface [polypeptide binding]; other site 698971003876 DNA binding site [nucleotide binding] 698971003877 potential frameshift: common BLAST hit: gi|336326698|ref|YP_004606664.1| transposase for insertion sequence element 698971003878 MULE transposase domain; Region: MULE; pfam10551 698971003879 potential frameshift: common BLAST hit: gi|68536874|ref|YP_251579.1| transposase IS3525 698971003880 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698971003881 potential frameshift: common BLAST hit: gi|336326698|ref|YP_004606664.1| transposase for insertion sequence element 698971003882 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698971003883 6-carboxyhexanoate--CoA ligase; Region: BioW; pfam03744 698971003884 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 698971003885 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698971003886 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698971003887 catalytic residue [active] 698971003888 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698971003889 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698971003890 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 698971003891 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 698971003892 putative acyl-acceptor binding pocket; other site 698971003893 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 698971003894 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 698971003895 nucleotide binding site/active site [active] 698971003896 HIT family signature motif; other site 698971003897 catalytic residue [active] 698971003898 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 698971003899 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 698971003900 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 698971003901 active site 698971003902 dimer interface [polypeptide binding]; other site 698971003903 motif 1; other site 698971003904 motif 2; other site 698971003905 motif 3; other site 698971003906 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 698971003907 anticodon binding site; other site 698971003908 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 698971003909 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 698971003910 Protein of unknown function (DUF461); Region: DUF461; pfam04314 698971003911 CopC domain; Region: CopC; cl01012 698971003912 hypothetical protein; Provisional; Region: PRK14059 698971003913 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 698971003914 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 698971003915 SelR domain; Region: SelR; pfam01641 698971003916 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 698971003917 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 698971003918 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 698971003919 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 698971003920 catalytic site [active] 698971003921 putative active site [active] 698971003922 putative substrate binding site [chemical binding]; other site 698971003923 HRDC domain; Region: HRDC; pfam00570 698971003924 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 698971003925 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 698971003926 TPP-binding site; other site 698971003927 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 698971003928 PYR/PP interface [polypeptide binding]; other site 698971003929 dimer interface [polypeptide binding]; other site 698971003930 TPP binding site [chemical binding]; other site 698971003931 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698971003932 TRAM domain; Region: TRAM; cl01282 698971003933 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 698971003934 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 698971003935 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 698971003936 trimer interface [polypeptide binding]; other site 698971003937 active site 698971003938 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 698971003939 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 698971003940 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 698971003941 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698971003942 active site 698971003943 dimerization interface [polypeptide binding]; other site 698971003944 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698971003945 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698971003946 nucleotide binding site [chemical binding]; other site 698971003947 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 698971003948 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 698971003949 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698971003950 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 698971003951 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698971003952 DNA binding residues [nucleotide binding] 698971003953 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698971003954 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698971003955 ATP binding site [chemical binding]; other site 698971003956 putative Mg++ binding site [ion binding]; other site 698971003957 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 698971003958 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 698971003959 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 698971003960 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698971003961 S-adenosylmethionine binding site [chemical binding]; other site 698971003962 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 698971003963 putative active site [active] 698971003964 dimerization interface [polypeptide binding]; other site 698971003965 putative tRNAtyr binding site [nucleotide binding]; other site 698971003966 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 698971003967 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 698971003968 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698971003969 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 698971003970 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698971003971 DNA binding residues [nucleotide binding] 698971003972 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 698971003973 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 698971003974 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 698971003975 FeoA domain; Region: FeoA; cl00838 698971003976 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 698971003977 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 698971003978 NAD binding site [chemical binding]; other site 698971003979 homodimer interface [polypeptide binding]; other site 698971003980 active site 698971003981 substrate binding site [chemical binding]; other site 698971003982 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 698971003983 PAC2 family; Region: PAC2; pfam09754 698971003984 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698971003985 ATP binding site [chemical binding]; other site 698971003986 putative Mg++ binding site [ion binding]; other site 698971003987 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698971003988 nucleotide binding region [chemical binding]; other site 698971003989 ATP-binding site [chemical binding]; other site 698971003990 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 698971003991 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 698971003992 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 698971003993 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 698971003994 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 698971003995 dimer interface [polypeptide binding]; other site 698971003996 decamer (pentamer of dimers) interface [polypeptide binding]; other site 698971003997 catalytic triad [active] 698971003998 peroxidatic and resolving cysteines [active] 698971003999 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698971004000 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 698971004001 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 698971004002 dimerization interface [polypeptide binding]; other site 698971004003 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 698971004004 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698971004005 ATP binding site [chemical binding]; other site 698971004006 putative Mg++ binding site [ion binding]; other site 698971004007 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698971004008 nucleotide binding region [chemical binding]; other site 698971004009 ATP-binding site [chemical binding]; other site 698971004010 Helicase associated domain (HA2); Region: HA2; pfam04408 698971004011 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 698971004012 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 698971004013 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 698971004014 ATP cone domain; Region: ATP-cone; pfam03477 698971004015 LexA repressor; Validated; Region: PRK00215 698971004016 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 698971004017 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 698971004018 Catalytic site [active] 698971004019 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698971004020 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 698971004021 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698971004022 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 698971004023 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 698971004024 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 698971004025 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 698971004026 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698971004027 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698971004028 DNA-binding site [nucleotide binding]; DNA binding site 698971004029 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698971004030 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 698971004031 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 698971004032 putative substrate binding site [chemical binding]; other site 698971004033 putative ATP binding site [chemical binding]; other site 698971004034 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 698971004035 dimerization domain swap beta strand [polypeptide binding]; other site 698971004036 regulatory protein interface [polypeptide binding]; other site 698971004037 active site 698971004038 regulatory phosphorylation site [posttranslational modification]; other site 698971004039 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 698971004040 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 698971004041 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 698971004042 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698971004043 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 698971004044 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 698971004045 GTPases [General function prediction only]; Region: HflX; COG2262 698971004046 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 698971004047 HflX GTPase family; Region: HflX; cd01878 698971004048 G1 box; other site 698971004049 GTP/Mg2+ binding site [chemical binding]; other site 698971004050 Switch I region; other site 698971004051 G2 box; other site 698971004052 G3 box; other site 698971004053 Switch II region; other site 698971004054 G4 box; other site 698971004055 G5 box; other site 698971004056 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 698971004057 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 698971004058 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 698971004059 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 698971004060 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 698971004061 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 698971004062 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 698971004063 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 698971004064 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698971004065 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 698971004066 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 698971004067 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698971004068 FeS/SAM binding site; other site 698971004069 recombination regulator RecX; Reviewed; Region: recX; PRK00117 698971004070 recombinase A; Provisional; Region: recA; PRK09354 698971004071 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 698971004072 hexamer interface [polypeptide binding]; other site 698971004073 Walker A motif; other site 698971004074 ATP binding site [chemical binding]; other site 698971004075 Walker B motif; other site 698971004076 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 698971004077 BioY family; Region: BioY; pfam02632 698971004078 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698971004079 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698971004080 Walker A/P-loop; other site 698971004081 ATP binding site [chemical binding]; other site 698971004082 Q-loop/lid; other site 698971004083 ABC transporter signature motif; other site 698971004084 Walker B; other site 698971004085 D-loop; other site 698971004086 H-loop/switch region; other site 698971004087 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 698971004088 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 698971004089 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698971004090 sequence-specific DNA binding site [nucleotide binding]; other site 698971004091 salt bridge; other site 698971004092 Competence-damaged protein; Region: CinA; pfam02464 698971004093 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 698971004094 YCII-related domain; Region: YCII; cl00999 698971004095 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 698971004096 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 698971004097 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698971004098 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 698971004099 TIGR03085 family protein; Region: TIGR03085 698971004100 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 698971004101 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 698971004102 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 698971004103 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 698971004104 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698971004105 dimer interface [polypeptide binding]; other site 698971004106 active site 698971004107 catalytic residue [active] 698971004108 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 698971004109 dihydrodipicolinate reductase; Provisional; Region: PRK00048 698971004110 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 698971004111 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 698971004112 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 698971004113 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 698971004114 oligomer interface [polypeptide binding]; other site 698971004115 RNA binding site [nucleotide binding]; other site 698971004116 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 698971004117 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 698971004118 RNase E interface [polypeptide binding]; other site 698971004119 trimer interface [polypeptide binding]; other site 698971004120 active site 698971004121 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 698971004122 putative nucleic acid binding region [nucleotide binding]; other site 698971004123 G-X-X-G motif; other site 698971004124 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 698971004125 RNA binding site [nucleotide binding]; other site 698971004126 domain interface; other site 698971004127 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 698971004128 16S/18S rRNA binding site [nucleotide binding]; other site 698971004129 S13e-L30e interaction site [polypeptide binding]; other site 698971004130 25S rRNA binding site [nucleotide binding]; other site 698971004131 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 698971004132 active site 698971004133 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 698971004134 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 698971004135 active site 698971004136 Riboflavin kinase; Region: Flavokinase; smart00904 698971004137 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 698971004138 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 698971004139 RNA binding site [nucleotide binding]; other site 698971004140 active site 698971004141 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 698971004142 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 698971004143 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 698971004144 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698971004145 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 698971004146 active site 698971004147 metal binding site [ion binding]; metal-binding site 698971004148 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 698971004149 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 698971004150 DHH family; Region: DHH; pfam01368 698971004151 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 698971004152 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698971004153 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698971004154 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 698971004155 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 698971004156 G1 box; other site 698971004157 putative GEF interaction site [polypeptide binding]; other site 698971004158 GTP/Mg2+ binding site [chemical binding]; other site 698971004159 Switch I region; other site 698971004160 G2 box; other site 698971004161 G3 box; other site 698971004162 Switch II region; other site 698971004163 G4 box; other site 698971004164 G5 box; other site 698971004165 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 698971004166 Translation-initiation factor 2; Region: IF-2; pfam11987 698971004167 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 698971004168 Protein of unknown function (DUF448); Region: DUF448; pfam04296 698971004169 putative RNA binding cleft [nucleotide binding]; other site 698971004170 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 698971004171 NusA N-terminal domain; Region: NusA_N; pfam08529 698971004172 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 698971004173 RNA binding site [nucleotide binding]; other site 698971004174 homodimer interface [polypeptide binding]; other site 698971004175 NusA-like KH domain; Region: KH_5; pfam13184 698971004176 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 698971004177 G-X-X-G motif; other site 698971004178 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 698971004179 Sm and related proteins; Region: Sm_like; cl00259 698971004180 prolyl-tRNA synthetase; Provisional; Region: PRK09194 698971004181 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 698971004182 dimer interface [polypeptide binding]; other site 698971004183 motif 1; other site 698971004184 active site 698971004185 motif 2; other site 698971004186 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 698971004187 putative deacylase active site [active] 698971004188 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698971004189 active site 698971004190 motif 3; other site 698971004191 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 698971004192 anticodon binding site; other site 698971004193 hypothetical protein; Validated; Region: PRK02101 698971004194 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 698971004195 active site 698971004196 SAM binding site [chemical binding]; other site 698971004197 homodimer interface [polypeptide binding]; other site 698971004198 Uncharacterized conserved protein [Function unknown]; Region: COG0397 698971004199 hypothetical protein; Validated; Region: PRK00029 698971004200 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 698971004201 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 698971004202 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 698971004203 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 698971004204 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 698971004205 DNA binding site [nucleotide binding] 698971004206 active site 698971004207 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 698971004208 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 698971004209 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 698971004210 catalytic triad [active] 698971004211 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 698971004212 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 698971004213 Walker A motif; other site 698971004214 homodimer interface [polypeptide binding]; other site 698971004215 ATP binding site [chemical binding]; other site 698971004216 hydroxycobalamin binding site [chemical binding]; other site 698971004217 Walker B motif; other site 698971004218 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 698971004219 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 698971004220 metal ion-dependent adhesion site (MIDAS); other site 698971004221 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 698971004222 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698971004223 Walker A motif; other site 698971004224 ATP binding site [chemical binding]; other site 698971004225 Walker B motif; other site 698971004226 arginine finger; other site 698971004227 malate:quinone oxidoreductase; Validated; Region: PRK05257 698971004228 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 698971004229 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 698971004230 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698971004231 mycothione reductase; Region: mycothione_red; TIGR03452 698971004232 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698971004233 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698971004234 cobyric acid synthase; Provisional; Region: PRK00784 698971004235 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 698971004236 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698971004237 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 698971004238 catalytic triad [active] 698971004239 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 698971004240 active site 698971004241 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 698971004242 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 698971004243 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 698971004244 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 698971004245 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 698971004246 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 698971004247 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 698971004248 active site 698971004249 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 698971004250 protein binding site [polypeptide binding]; other site 698971004251 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 698971004252 putative substrate binding region [chemical binding]; other site 698971004253 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 698971004254 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 698971004255 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 698971004256 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 698971004257 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 698971004258 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 698971004259 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698971004260 FeS/SAM binding site; other site 698971004261 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 698971004262 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 698971004263 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 698971004264 ribosome recycling factor; Reviewed; Region: frr; PRK00083 698971004265 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 698971004266 hinge region; other site 698971004267 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 698971004268 putative nucleotide binding site [chemical binding]; other site 698971004269 uridine monophosphate binding site [chemical binding]; other site 698971004270 homohexameric interface [polypeptide binding]; other site 698971004271 elongation factor Ts; Provisional; Region: tsf; PRK09377 698971004272 UBA/TS-N domain; Region: UBA; pfam00627 698971004273 Elongation factor TS; Region: EF_TS; pfam00889 698971004274 Elongation factor TS; Region: EF_TS; pfam00889 698971004275 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 698971004276 rRNA interaction site [nucleotide binding]; other site 698971004277 S8 interaction site; other site 698971004278 putative laminin-1 binding site; other site 698971004279 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 698971004280 Peptidase family M23; Region: Peptidase_M23; pfam01551 698971004281 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698971004282 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 698971004283 active site 698971004284 DNA binding site [nucleotide binding] 698971004285 Int/Topo IB signature motif; other site 698971004286 DNA protecting protein DprA; Region: dprA; TIGR00732 698971004287 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 698971004288 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 698971004289 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 698971004290 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698971004291 Walker A motif; other site 698971004292 ATP binding site [chemical binding]; other site 698971004293 Walker B motif; other site 698971004294 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 698971004295 hypothetical protein; Reviewed; Region: PRK12497 698971004296 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 698971004297 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 698971004298 RNA/DNA hybrid binding site [nucleotide binding]; other site 698971004299 active site 698971004300 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 698971004301 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 698971004302 Catalytic site [active] 698971004303 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 698971004304 Htaa; Region: HtaA; pfam04213 698971004305 Htaa; Region: HtaA; pfam04213 698971004306 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 698971004307 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 698971004308 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 698971004309 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 698971004310 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698971004311 RNA binding site [nucleotide binding]; other site 698971004312 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 698971004313 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 698971004314 RimM N-terminal domain; Region: RimM; pfam01782 698971004315 PRC-barrel domain; Region: PRC; pfam05239 698971004316 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 698971004317 signal recognition particle protein; Provisional; Region: PRK10867 698971004318 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 698971004319 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 698971004320 P loop; other site 698971004321 GTP binding site [chemical binding]; other site 698971004322 Signal peptide binding domain; Region: SRP_SPB; pfam02978 698971004323 PII uridylyl-transferase; Provisional; Region: glnD; PRK00227 698971004324 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698971004325 metal binding triad; other site 698971004326 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698971004327 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 698971004328 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 698971004329 Nitrogen regulatory protein P-II; Region: P-II; smart00938 698971004330 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 698971004331 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 698971004332 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 698971004333 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698971004334 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 698971004335 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 698971004336 Walker A/P-loop; other site 698971004337 ATP binding site [chemical binding]; other site 698971004338 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 698971004339 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 698971004340 ABC transporter signature motif; other site 698971004341 Walker B; other site 698971004342 D-loop; other site 698971004343 H-loop/switch region; other site 698971004344 Acylphosphatase; Region: Acylphosphatase; cl00551 698971004345 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 698971004346 amino acid carrier protein; Region: agcS; TIGR00835 698971004347 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 698971004348 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 698971004349 DNA binding site [nucleotide binding] 698971004350 catalytic residue [active] 698971004351 H2TH interface [polypeptide binding]; other site 698971004352 putative catalytic residues [active] 698971004353 turnover-facilitating residue; other site 698971004354 intercalation triad [nucleotide binding]; other site 698971004355 8OG recognition residue [nucleotide binding]; other site 698971004356 putative reading head residues; other site 698971004357 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698971004358 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 698971004359 ribonuclease III; Reviewed; Region: rnc; PRK00102 698971004360 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 698971004361 dimerization interface [polypeptide binding]; other site 698971004362 active site 698971004363 metal binding site [ion binding]; metal-binding site 698971004364 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 698971004365 dsRNA binding site [nucleotide binding]; other site 698971004366 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 698971004367 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 698971004368 glutamate dehydrogenase; Provisional; Region: PRK09414 698971004369 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 698971004370 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 698971004371 NAD(P) binding site [chemical binding]; other site 698971004372 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 698971004373 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 698971004374 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698971004375 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 698971004376 metal binding site [ion binding]; metal-binding site 698971004377 putative dimer interface [polypeptide binding]; other site 698971004378 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 698971004379 homodimer interface [polypeptide binding]; other site 698971004380 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 698971004381 active site pocket [active] 698971004382 pyruvate kinase; Provisional; Region: PRK06247 698971004383 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 698971004384 domain interfaces; other site 698971004385 active site 698971004386 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 698971004387 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 698971004388 active site 698971004389 ribulose/triose binding site [chemical binding]; other site 698971004390 phosphate binding site [ion binding]; other site 698971004391 substrate (anthranilate) binding pocket [chemical binding]; other site 698971004392 product (indole) binding pocket [chemical binding]; other site 698971004393 trp region conserved hypothetical membrane protein; Region: trp_oprn_chp; TIGR02234 698971004394 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 698971004395 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 698971004396 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 698971004397 substrate binding site [chemical binding]; other site 698971004398 glutamase interaction surface [polypeptide binding]; other site 698971004399 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 698971004400 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698971004401 active site 698971004402 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 698971004403 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 698971004404 catalytic residues [active] 698971004405 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 698971004406 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 698971004407 putative active site [active] 698971004408 oxyanion strand; other site 698971004409 catalytic triad [active] 698971004410 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698971004411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698971004412 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 698971004413 putative active site pocket [active] 698971004414 4-fold oligomerization interface [polypeptide binding]; other site 698971004415 metal binding residues [ion binding]; metal-binding site 698971004416 3-fold/trimer interface [polypeptide binding]; other site 698971004417 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 698971004418 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698971004419 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698971004420 homodimer interface [polypeptide binding]; other site 698971004421 catalytic residue [active] 698971004422 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 698971004423 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 698971004424 NAD binding site [chemical binding]; other site 698971004425 dimerization interface [polypeptide binding]; other site 698971004426 product binding site; other site 698971004427 substrate binding site [chemical binding]; other site 698971004428 zinc binding site [ion binding]; other site 698971004429 catalytic residues [active] 698971004430 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 698971004431 tetracycline repressor protein TetR; Provisional; Region: PRK13756 698971004432 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698971004433 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 698971004434 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 698971004435 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 698971004436 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 698971004437 active site 698971004438 catalytic site [active] 698971004439 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 698971004440 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 698971004441 active site 698971004442 catalytic site [active] 698971004443 substrate binding site [chemical binding]; other site 698971004444 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 698971004445 synthetase active site [active] 698971004446 NTP binding site [chemical binding]; other site 698971004447 metal binding site [ion binding]; metal-binding site 698971004448 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698971004449 RNA binding surface [nucleotide binding]; other site 698971004450 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 698971004451 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 698971004452 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 698971004453 threonine dehydratase; Validated; Region: PRK08639 698971004454 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 698971004455 tetramer interface [polypeptide binding]; other site 698971004456 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698971004457 catalytic residue [active] 698971004458 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 698971004459 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 698971004460 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 698971004461 active site 698971004462 PHP Thumb interface [polypeptide binding]; other site 698971004463 metal binding site [ion binding]; metal-binding site 698971004464 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 698971004465 generic binding surface II; other site 698971004466 generic binding surface I; other site 698971004467 Predicted permeases [General function prediction only]; Region: RarD; COG2962 698971004468 EamA-like transporter family; Region: EamA; cl17759 698971004469 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 698971004470 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698971004471 RNA binding surface [nucleotide binding]; other site 698971004472 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 698971004473 active site 698971004474 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 698971004475 lipoprotein signal peptidase; Provisional; Region: PRK14787 698971004476 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 698971004477 active site 698971004478 homotetramer interface [polypeptide binding]; other site 698971004479 homodimer interface [polypeptide binding]; other site 698971004480 DNA polymerase IV; Provisional; Region: PRK03348 698971004481 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 698971004482 active site 698971004483 DNA binding site [nucleotide binding] 698971004484 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 698971004485 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 698971004486 HIGH motif; other site 698971004487 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 698971004488 active site 698971004489 KMSKS motif; other site 698971004490 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 698971004491 tRNA binding surface [nucleotide binding]; other site 698971004492 anticodon binding site; other site 698971004493 DivIVA domain; Region: DivI1A_domain; TIGR03544 698971004494 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 698971004495 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 698971004496 YGGT family; Region: YGGT; cl00508 698971004497 Protein of unknown function (DUF552); Region: DUF552; cl00775 698971004498 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 698971004499 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 698971004500 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 698971004501 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 698971004502 nucleotide binding site [chemical binding]; other site 698971004503 SulA interaction site; other site 698971004504 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 698971004505 Cell division protein FtsQ; Region: FtsQ; pfam03799 698971004506 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 698971004507 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698971004508 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698971004509 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698971004510 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 698971004511 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 698971004512 active site 698971004513 homodimer interface [polypeptide binding]; other site 698971004514 cell division protein FtsW; Region: ftsW; TIGR02614 698971004515 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141 698971004516 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698971004517 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698971004518 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 698971004519 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 698971004520 Mg++ binding site [ion binding]; other site 698971004521 putative catalytic motif [active] 698971004522 putative substrate binding site [chemical binding]; other site 698971004523 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 698971004524 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698971004525 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698971004526 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698971004527 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 698971004528 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698971004529 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698971004530 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698971004531 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 698971004532 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 698971004533 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698971004534 MraW methylase family; Region: Methyltransf_5; cl17771 698971004535 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 698971004536 cell division protein MraZ; Reviewed; Region: PRK00326 698971004537 MraZ protein; Region: MraZ; pfam02381 698971004538 MraZ protein; Region: MraZ; pfam02381 698971004539 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 698971004540 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 698971004541 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698971004542 Coenzyme A binding pocket [chemical binding]; other site 698971004543 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 698971004544 FAD binding site [chemical binding]; other site 698971004545 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 698971004546 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 698971004547 substrate binding pocket [chemical binding]; other site 698971004548 chain length determination region; other site 698971004549 substrate-Mg2+ binding site; other site 698971004550 catalytic residues [active] 698971004551 aspartate-rich region 1; other site 698971004552 active site lid residues [active] 698971004553 aspartate-rich region 2; other site 698971004554 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 698971004555 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698971004556 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698971004557 active site 698971004558 ATP binding site [chemical binding]; other site 698971004559 substrate binding site [chemical binding]; other site 698971004560 activation loop (A-loop); other site 698971004561 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 698971004562 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698971004563 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698971004564 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698971004565 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698971004566 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 698971004567 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 698971004568 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 698971004569 putative acyl-acceptor binding pocket; other site 698971004570 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698971004571 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698971004572 nucleotide binding site [chemical binding]; other site 698971004573 Tesmin/TSO1-like CXC domain; Region: CXC; pfam03638 698971004574 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698971004575 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698971004576 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698971004577 NlpC/P60 family; Region: NLPC_P60; pfam00877 698971004578 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698971004579 NlpC/P60 family; Region: NLPC_P60; pfam00877 698971004580 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 698971004581 heme bH binding site [chemical binding]; other site 698971004582 intrachain domain interface; other site 698971004583 heme bL binding site [chemical binding]; other site 698971004584 interchain domain interface [polypeptide binding]; other site 698971004585 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 698971004586 Qo binding site; other site 698971004587 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 698971004588 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 698971004589 iron-sulfur cluster [ion binding]; other site 698971004590 [2Fe-2S] cluster binding site [ion binding]; other site 698971004591 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 698971004592 Cytochrome c; Region: Cytochrom_C; pfam00034 698971004593 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 698971004594 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 698971004595 Subunit I/III interface [polypeptide binding]; other site 698971004596 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 698971004597 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 698971004598 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 698971004599 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 698971004600 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 698971004601 active site 698971004602 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 698971004603 Ligand Binding Site [chemical binding]; other site 698971004604 Molecular Tunnel; other site 698971004605 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 698971004606 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 698971004607 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 698971004608 homotrimer interface [polypeptide binding]; other site 698971004609 Walker A motif; other site 698971004610 GTP binding site [chemical binding]; other site 698971004611 Walker B motif; other site 698971004612 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 698971004613 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 698971004614 putative dimer interface [polypeptide binding]; other site 698971004615 active site pocket [active] 698971004616 putative cataytic base [active] 698971004617 cobalamin synthase; Reviewed; Region: cobS; PRK00235 698971004618 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 698971004619 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 698971004620 homodimer interface [polypeptide binding]; other site 698971004621 substrate-cofactor binding pocket; other site 698971004622 catalytic residue [active] 698971004623 multifunctional aminopeptidase A; Provisional; Region: PRK00913 698971004624 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 698971004625 interface (dimer of trimers) [polypeptide binding]; other site 698971004626 Substrate-binding/catalytic site; other site 698971004627 Zn-binding sites [ion binding]; other site 698971004628 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 698971004629 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698971004630 E3 interaction surface; other site 698971004631 lipoyl attachment site [posttranslational modification]; other site 698971004632 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698971004633 E3 interaction surface; other site 698971004634 lipoyl attachment site [posttranslational modification]; other site 698971004635 e3 binding domain; Region: E3_binding; pfam02817 698971004636 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 698971004637 lipoate-protein ligase B; Provisional; Region: PRK14345 698971004638 lipoyl synthase; Provisional; Region: PRK05481 698971004639 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698971004640 FeS/SAM binding site; other site 698971004641 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 698971004642 RDD family; Region: RDD; pfam06271 698971004643 glutamine synthetase, type I; Region: GlnA; TIGR00653 698971004644 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 698971004645 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698971004646 Predicted peptidase [General function prediction only]; Region: COG4099 698971004647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 698971004648 Predicted permease [General function prediction only]; Region: COG2056 698971004649 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 698971004650 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698971004651 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698971004652 DNA-binding site [nucleotide binding]; DNA binding site 698971004653 FCD domain; Region: FCD; pfam07729 698971004654 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698971004655 putative substrate translocation pore; other site 698971004656 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 698971004657 nudix motif; other site 698971004658 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 698971004659 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 698971004660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698971004661 catalytic residue [active] 698971004662 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 698971004663 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 698971004664 heme binding pocket [chemical binding]; other site 698971004665 heme ligand [chemical binding]; other site 698971004666 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 698971004667 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698971004668 metal binding triad; other site 698971004669 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698971004670 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698971004671 metal binding triad; other site 698971004672 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698971004673 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 698971004674 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 698971004675 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698971004676 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 698971004677 putative active site; other site 698971004678 putative metal binding residues [ion binding]; other site 698971004679 signature motif; other site 698971004680 putative triphosphate binding site [ion binding]; other site 698971004681 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 698971004682 galactokinase; Provisional; Region: PRK00555 698971004683 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 698971004684 potential frameshift: common BLAST hit: gi|300858911|ref|YP_003783894.1| ribonuclease R 698971004685 RNB domain; Region: RNB; pfam00773 698971004686 Predicted membrane protein [General function prediction only]; Region: COG4194 698971004687 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 698971004688 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 698971004689 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 698971004690 RNA/DNA hybrid binding site [nucleotide binding]; other site 698971004691 active site 698971004692 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698971004693 catalytic core [active] 698971004694 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 698971004695 Putative zinc ribbon domain; Region: DUF164; pfam02591 698971004696 Uncharacterized conserved protein [Function unknown]; Region: COG0327 698971004697 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 698971004698 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 698971004699 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 698971004700 hypothetical protein; Provisional; Region: PRK07908 698971004701 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698971004702 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698971004703 homodimer interface [polypeptide binding]; other site 698971004704 catalytic residue [active] 698971004705 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 698971004706 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698971004707 motif II; other site 698971004708 Low molecular weight phosphatase family; Region: LMWPc; cd00115 698971004709 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 698971004710 active site 698971004711 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 698971004712 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 698971004713 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 698971004714 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 698971004715 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 698971004716 dimer interface [polypeptide binding]; other site 698971004717 TPP-binding site [chemical binding]; other site 698971004718 Electron transfer DM13; Region: DM13; pfam10517 698971004719 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698971004720 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 698971004721 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698971004722 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 698971004723 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698971004724 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 698971004725 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698971004726 active site 698971004727 motif I; other site 698971004728 motif II; other site 698971004729 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698971004730 motif II; other site 698971004731 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 698971004732 Beta-lactamase; Region: Beta-lactamase; pfam00144 698971004733 Predicted membrane protein [Function unknown]; Region: COG2860 698971004734 UPF0126 domain; Region: UPF0126; pfam03458 698971004735 UPF0126 domain; Region: UPF0126; pfam03458 698971004736 DNA primase; Validated; Region: dnaG; PRK05667 698971004737 CHC2 zinc finger; Region: zf-CHC2; pfam01807 698971004738 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 698971004739 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 698971004740 active site 698971004741 metal binding site [ion binding]; metal-binding site 698971004742 interdomain interaction site; other site 698971004743 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 698971004744 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 698971004745 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 698971004746 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 698971004747 glutaminase active site [active] 698971004748 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 698971004749 dimer interface [polypeptide binding]; other site 698971004750 active site 698971004751 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 698971004752 dimer interface [polypeptide binding]; other site 698971004753 active site 698971004754 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 698971004755 active site 698971004756 barstar interaction site; other site 698971004757 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 698971004758 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698971004759 Zn2+ binding site [ion binding]; other site 698971004760 Mg2+ binding site [ion binding]; other site 698971004761 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 698971004762 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 698971004763 putative active site [active] 698971004764 Repair protein; Region: Repair_PSII; pfam04536 698971004765 glycyl-tRNA synthetase; Provisional; Region: PRK04173 698971004766 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698971004767 motif 1; other site 698971004768 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 698971004769 active site 698971004770 motif 2; other site 698971004771 motif 3; other site 698971004772 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 698971004773 anticodon binding site; other site 698971004774 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698971004775 putative DNA binding site [nucleotide binding]; other site 698971004776 dimerization interface [polypeptide binding]; other site 698971004777 putative Zn2+ binding site [ion binding]; other site 698971004778 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 698971004779 metal binding site 2 [ion binding]; metal-binding site 698971004780 putative DNA binding helix; other site 698971004781 metal binding site 1 [ion binding]; metal-binding site 698971004782 dimer interface [polypeptide binding]; other site 698971004783 structural Zn2+ binding site [ion binding]; other site 698971004784 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 698971004785 diiron binding motif [ion binding]; other site 698971004786 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 698971004787 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 698971004788 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 698971004789 catalytic residue [active] 698971004790 putative FPP diphosphate binding site; other site 698971004791 putative FPP binding hydrophobic cleft; other site 698971004792 dimer interface [polypeptide binding]; other site 698971004793 putative IPP diphosphate binding site; other site 698971004794 Recombination protein O N terminal; Region: RecO_N; pfam11967 698971004795 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 698971004796 Recombination protein O C terminal; Region: RecO_C; pfam02565 698971004797 GTPase Era; Reviewed; Region: era; PRK00089 698971004798 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 698971004799 G1 box; other site 698971004800 GTP/Mg2+ binding site [chemical binding]; other site 698971004801 Switch I region; other site 698971004802 G2 box; other site 698971004803 Switch II region; other site 698971004804 G3 box; other site 698971004805 G4 box; other site 698971004806 G5 box; other site 698971004807 KH domain; Region: KH_2; pfam07650 698971004808 pyridoxamine kinase; Validated; Region: PRK05756 698971004809 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 698971004810 dimer interface [polypeptide binding]; other site 698971004811 pyridoxal binding site [chemical binding]; other site 698971004812 ATP binding site [chemical binding]; other site 698971004813 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698971004814 Domain of unknown function DUF21; Region: DUF21; pfam01595 698971004815 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698971004816 Transporter associated domain; Region: CorC_HlyC; smart01091 698971004817 metal-binding heat shock protein; Provisional; Region: PRK00016 698971004818 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 698971004819 PhoH-like protein; Region: PhoH; pfam02562 698971004820 RNA methyltransferase, RsmE family; Region: TIGR00046 698971004821 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 698971004822 chaperone protein DnaJ; Provisional; Region: PRK14278 698971004823 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698971004824 HSP70 interaction site [polypeptide binding]; other site 698971004825 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 698971004826 Zn binding sites [ion binding]; other site 698971004827 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 698971004828 dimer interface [polypeptide binding]; other site 698971004829 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 698971004830 coproporphyrinogen III oxidase; Validated; Region: PRK05628 698971004831 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698971004832 FeS/SAM binding site; other site 698971004833 HemN C-terminal domain; Region: HemN_C; pfam06969 698971004834 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698971004835 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 698971004836 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698971004837 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698971004838 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 698971004839 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 698971004840 acyl-activating enzyme (AAE) consensus motif; other site 698971004841 putative AMP binding site [chemical binding]; other site 698971004842 putative active site [active] 698971004843 putative CoA binding site [chemical binding]; other site 698971004844 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 698971004845 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 698971004846 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 698971004847 active site 698971004848 Zn binding site [ion binding]; other site 698971004849 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 698971004850 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 698971004851 substrate binding pocket [chemical binding]; other site 698971004852 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 698971004853 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 698971004854 active site 698971004855 metal binding site [ion binding]; metal-binding site 698971004856 nudix motif; other site 698971004857 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698971004858 active site 698971004859 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698971004860 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698971004861 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698971004862 Walker A/P-loop; other site 698971004863 ATP binding site [chemical binding]; other site 698971004864 Q-loop/lid; other site 698971004865 ABC transporter signature motif; other site 698971004866 Walker B; other site 698971004867 D-loop; other site 698971004868 H-loop/switch region; other site 698971004869 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 698971004870 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698971004871 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698971004872 homodimer interface [polypeptide binding]; other site 698971004873 catalytic residue [active] 698971004874 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 698971004875 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 698971004876 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 698971004877 BCCT family transporter; Region: BCCT; pfam02028 698971004878 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698971004879 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 698971004880 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698971004881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698971004882 dimer interface [polypeptide binding]; other site 698971004883 conserved gate region; other site 698971004884 putative PBP binding loops; other site 698971004885 ABC-ATPase subunit interface; other site 698971004886 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698971004887 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698971004888 dimer interface [polypeptide binding]; other site 698971004889 conserved gate region; other site 698971004890 putative PBP binding loops; other site 698971004891 ABC-ATPase subunit interface; other site 698971004892 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698971004893 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698971004894 Walker A/P-loop; other site 698971004895 ATP binding site [chemical binding]; other site 698971004896 Q-loop/lid; other site 698971004897 ABC transporter signature motif; other site 698971004898 Walker B; other site 698971004899 D-loop; other site 698971004900 H-loop/switch region; other site 698971004901 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698971004902 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698971004903 Walker A/P-loop; other site 698971004904 ATP binding site [chemical binding]; other site 698971004905 Q-loop/lid; other site 698971004906 ABC transporter signature motif; other site 698971004907 Walker B; other site 698971004908 D-loop; other site 698971004909 H-loop/switch region; other site 698971004910 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698971004911 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 698971004912 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 698971004913 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698971004914 catalytic residue [active] 698971004915 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 698971004916 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 698971004917 nucleotide binding site [chemical binding]; other site 698971004918 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 698971004919 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698971004920 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698971004921 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 698971004922 active site residue [active] 698971004923 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 698971004924 putative homodimer interface [polypeptide binding]; other site 698971004925 putative homotetramer interface [polypeptide binding]; other site 698971004926 putative allosteric switch controlling residues; other site 698971004927 putative metal binding site [ion binding]; other site 698971004928 putative homodimer-homodimer interface [polypeptide binding]; other site 698971004929 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 698971004930 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 698971004931 TrkA-N domain; Region: TrkA_N; pfam02254 698971004932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698971004933 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698971004934 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 698971004935 active site 698971004936 tetramer interface [polypeptide binding]; other site 698971004937 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 698971004938 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 698971004939 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698971004940 Mrr N-terminal domain; Region: Mrr_N; pfam14338 698971004941 Restriction endonuclease; Region: Mrr_cat; pfam04471 698971004942 Abi-like protein; Region: Abi_2; pfam07751 698971004943 GTP-binding protein LepA; Provisional; Region: PRK05433 698971004944 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 698971004945 G1 box; other site 698971004946 putative GEF interaction site [polypeptide binding]; other site 698971004947 GTP/Mg2+ binding site [chemical binding]; other site 698971004948 Switch I region; other site 698971004949 G2 box; other site 698971004950 G3 box; other site 698971004951 Switch II region; other site 698971004952 G4 box; other site 698971004953 G5 box; other site 698971004954 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 698971004955 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 698971004956 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 698971004957 PemK-like protein; Region: PemK; pfam02452 698971004958 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 698971004959 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698971004960 hypothetical protein; Validated; Region: PRK05629 698971004961 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 698971004962 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 698971004963 Competence protein; Region: Competence; pfam03772 698971004964 comEA protein; Region: comE; TIGR01259 698971004965 Helix-hairpin-helix motif; Region: HHH; pfam00633 698971004966 helix-hairpin-helix signature motif; other site 698971004967 EDD domain protein, DegV family; Region: DegV; TIGR00762 698971004968 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 698971004969 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698971004970 catalytic core [active] 698971004971 Oligomerisation domain; Region: Oligomerisation; cl00519 698971004972 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 698971004973 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 698971004974 active site 698971004975 (T/H)XGH motif; other site 698971004976 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 698971004977 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 698971004978 putative catalytic cysteine [active] 698971004979 gamma-glutamyl kinase; Provisional; Region: PRK05429 698971004980 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 698971004981 nucleotide binding site [chemical binding]; other site 698971004982 homotetrameric interface [polypeptide binding]; other site 698971004983 putative phosphate binding site [ion binding]; other site 698971004984 putative allosteric binding site; other site 698971004985 PUA domain; Region: PUA; pfam01472 698971004986 GTPase CgtA; Reviewed; Region: obgE; PRK12296 698971004987 GTP1/OBG; Region: GTP1_OBG; pfam01018 698971004988 Obg GTPase; Region: Obg; cd01898 698971004989 G1 box; other site 698971004990 GTP/Mg2+ binding site [chemical binding]; other site 698971004991 Switch I region; other site 698971004992 G2 box; other site 698971004993 G3 box; other site 698971004994 Switch II region; other site 698971004995 G4 box; other site 698971004996 G5 box; other site 698971004997 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 698971004998 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 698971004999 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 698971005000 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 698971005001 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698971005002 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 698971005003 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 698971005004 homodimer interface [polypeptide binding]; other site 698971005005 oligonucleotide binding site [chemical binding]; other site 698971005006 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 698971005007 active site 698971005008 multimer interface [polypeptide binding]; other site 698971005009 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 698971005010 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 698971005011 dimer interface [polypeptide binding]; other site 698971005012 active site 698971005013 CoA binding pocket [chemical binding]; other site 698971005014 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698971005015 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 698971005016 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698971005017 catalytic residue [active] 698971005018 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 698971005019 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 698971005020 active site 698971005021 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698971005022 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 698971005023 Resolvase, N terminal domain; Region: Resolvase; pfam00239 698971005024 potential frameshift: common BLAST hit: gi|336115754|ref|YP_004570520.1| transposase 698971005025 Helix-turn-helix domain; Region: HTH_38; pfam13936 698971005026 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698971005027 Integrase core domain; Region: rve; pfam00665 698971005028 Integrase core domain; Region: rve_3; pfam13683 698971005029 potential frameshift: common BLAST hit: gi|68535288|ref|YP_249993.1| transposase IS3510a 698971005030 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698971005031 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698971005032 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 698971005033 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 698971005034 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698971005035 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 698971005036 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698971005037 active site 698971005038 HIGH motif; other site 698971005039 nucleotide binding site [chemical binding]; other site 698971005040 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 698971005041 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 698971005042 active site 698971005043 KMSKS motif; other site 698971005044 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 698971005045 tRNA binding surface [nucleotide binding]; other site 698971005046 anticodon binding site; other site 698971005047 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 698971005048 malate dehydrogenase; Provisional; Region: PRK05442 698971005049 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 698971005050 NAD(P) binding site [chemical binding]; other site 698971005051 dimer interface [polypeptide binding]; other site 698971005052 malate binding site [chemical binding]; other site 698971005053 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698971005054 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698971005055 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 698971005056 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 698971005057 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 698971005058 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698971005059 Walker A motif; other site 698971005060 ATP binding site [chemical binding]; other site 698971005061 Walker B motif; other site 698971005062 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 698971005063 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 698971005064 Glutamine amidotransferase class-I; Region: GATase; pfam00117 698971005065 glutamine binding [chemical binding]; other site 698971005066 catalytic triad [active] 698971005067 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 698971005068 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698971005069 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 698971005070 substrate-cofactor binding pocket; other site 698971005071 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698971005072 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 698971005073 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 698971005074 oligomer interface [polypeptide binding]; other site 698971005075 active site residues [active] 698971005076 Clp protease; Region: CLP_protease; pfam00574 698971005077 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 698971005078 oligomer interface [polypeptide binding]; other site 698971005079 active site residues [active] 698971005080 trigger factor; Provisional; Region: tig; PRK01490 698971005081 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 698971005082 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 698971005083 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 698971005084 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 698971005085 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 698971005086 catalytic residues [active] 698971005087 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 698971005088 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 698971005089 Zn binding site [ion binding]; other site 698971005090 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 698971005091 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698971005092 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 698971005093 apolar tunnel; other site 698971005094 heme binding site [chemical binding]; other site 698971005095 dimerization interface [polypeptide binding]; other site 698971005096 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 698971005097 active site 698971005098 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 698971005099 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698971005100 Walker A/P-loop; other site 698971005101 ATP binding site [chemical binding]; other site 698971005102 Q-loop/lid; other site 698971005103 ABC transporter signature motif; other site 698971005104 Walker B; other site 698971005105 D-loop; other site 698971005106 H-loop/switch region; other site 698971005107 ABC transporter; Region: ABC_tran_2; pfam12848 698971005108 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698971005109 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 698971005110 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698971005111 dimer interface [polypeptide binding]; other site 698971005112 ssDNA binding site [nucleotide binding]; other site 698971005113 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698971005114 Copper resistance protein D; Region: CopD; pfam05425 698971005115 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 698971005116 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 698971005117 Carbon starvation protein CstA; Region: CstA; pfam02554 698971005118 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 698971005119 Protein of unknown function (DUF466); Region: DUF466; pfam04328 698971005120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698971005121 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698971005122 putative substrate translocation pore; other site 698971005123 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 698971005124 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 698971005125 NADP binding site [chemical binding]; other site 698971005126 dimer interface [polypeptide binding]; other site 698971005127 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698971005128 classical (c) SDRs; Region: SDR_c; cd05233 698971005129 NAD(P) binding site [chemical binding]; other site 698971005130 active site 698971005131 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 698971005132 catalytic site [active] 698971005133 putative active site [active] 698971005134 putative substrate binding site [chemical binding]; other site 698971005135 dimer interface [polypeptide binding]; other site 698971005136 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 698971005137 inhibitor site; inhibition site 698971005138 active site 698971005139 dimer interface [polypeptide binding]; other site 698971005140 catalytic residue [active] 698971005141 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 698971005142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 698971005143 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 698971005144 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698971005145 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 698971005146 conserved cis-peptide bond; other site 698971005147 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 698971005148 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 698971005149 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 698971005150 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 698971005151 catalytic triad [active] 698971005152 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698971005153 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698971005154 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 698971005155 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 698971005156 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 698971005157 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698971005158 phosphate binding site [ion binding]; other site 698971005159 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 698971005160 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 698971005161 active site 2 [active] 698971005162 active site 1 [active] 698971005163 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 698971005164 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 698971005165 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 698971005166 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 698971005167 putative NAD(P) binding site [chemical binding]; other site 698971005168 active site 698971005169 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 698971005170 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 698971005171 active site 698971005172 Glucitol operon activator protein (GutM); Region: GutM; cl01890 698971005173 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 698971005174 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 698971005175 active site 698971005176 dimerization interface [polypeptide binding]; other site 698971005177 ribonuclease PH; Reviewed; Region: rph; PRK00173 698971005178 Ribonuclease PH; Region: RNase_PH_bact; cd11362 698971005179 hexamer interface [polypeptide binding]; other site 698971005180 active site 698971005181 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 698971005182 glutamate racemase; Provisional; Region: PRK00865 698971005183 Rhomboid family; Region: Rhomboid; cl11446 698971005184 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 698971005185 putative active site pocket [active] 698971005186 cleavage site 698971005187 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 698971005188 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 698971005189 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 698971005190 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 698971005191 active site 698971005192 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 698971005193 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698971005194 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698971005195 putative Mg++ binding site [ion binding]; other site 698971005196 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 698971005197 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698971005198 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 698971005199 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698971005200 active site 698971005201 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 698971005202 dimer interface [polypeptide binding]; other site 698971005203 putative active site [active] 698971005204 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 698971005205 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 698971005206 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 698971005207 phosphoserine phosphatase SerB; Region: serB; TIGR00338 698971005208 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698971005209 motif II; other site 698971005210 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 698971005211 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 698971005212 D-pathway; other site 698971005213 Putative ubiquinol binding site [chemical binding]; other site 698971005214 Low-spin heme (heme b) binding site [chemical binding]; other site 698971005215 Putative water exit pathway; other site 698971005216 Binuclear center (heme o3/CuB) [ion binding]; other site 698971005217 K-pathway; other site 698971005218 Putative proton exit pathway; other site 698971005219 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 698971005220 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 698971005221 dimer interface [polypeptide binding]; other site 698971005222 putative radical transfer pathway; other site 698971005223 diiron center [ion binding]; other site 698971005224 tyrosyl radical; other site 698971005225 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 698971005226 Ferritin-like domain; Region: Ferritin; pfam00210 698971005227 ferroxidase diiron center [ion binding]; other site 698971005228 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 698971005229 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 698971005230 Class I ribonucleotide reductase; Region: RNR_I; cd01679 698971005231 active site 698971005232 dimer interface [polypeptide binding]; other site 698971005233 catalytic residues [active] 698971005234 effector binding site; other site 698971005235 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 698971005236 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 698971005237 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 698971005238 catalytic residues [active] 698971005239 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 698971005240 active site lid residues [active] 698971005241 substrate binding pocket [chemical binding]; other site 698971005242 catalytic residues [active] 698971005243 substrate-Mg2+ binding site; other site 698971005244 aspartate-rich region 1; other site 698971005245 aspartate-rich region 2; other site 698971005246 phytoene desaturase; Region: crtI_fam; TIGR02734 698971005247 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698971005248 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 698971005249 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 698971005250 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 698971005251 homodimer interface [polypeptide binding]; other site 698971005252 NAD binding pocket [chemical binding]; other site 698971005253 ATP binding pocket [chemical binding]; other site 698971005254 Mg binding site [ion binding]; other site 698971005255 active-site loop [active] 698971005256 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 698971005257 Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719 698971005258 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 698971005259 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 698971005260 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 698971005261 Predicted transcriptional regulator [Transcription]; Region: COG2345 698971005262 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 698971005263 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 698971005264 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 698971005265 catalytic residues [active] 698971005266 Methylamine utilisation protein MauE; Region: MauE; pfam07291 698971005267 phosphoglucomutase; Validated; Region: PRK07564 698971005268 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 698971005269 active site 698971005270 substrate binding site [chemical binding]; other site 698971005271 metal binding site [ion binding]; metal-binding site 698971005272 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698971005273 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698971005274 FtsX-like permease family; Region: FtsX; pfam02687 698971005275 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698971005276 FtsX-like permease family; Region: FtsX; pfam02687 698971005277 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698971005278 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698971005279 Walker A/P-loop; other site 698971005280 ATP binding site [chemical binding]; other site 698971005281 Q-loop/lid; other site 698971005282 ABC transporter signature motif; other site 698971005283 Walker B; other site 698971005284 D-loop; other site 698971005285 H-loop/switch region; other site 698971005286 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 698971005287 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 698971005288 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 698971005289 hinge; other site 698971005290 active site 698971005291 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 698971005292 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 698971005293 GAF domain; Region: GAF_2; pfam13185 698971005294 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698971005295 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698971005296 DNA binding residues [nucleotide binding] 698971005297 dimerization interface [polypeptide binding]; other site 698971005298 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 698971005299 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 698971005300 dimer interface [polypeptide binding]; other site 698971005301 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698971005302 catalytic residue [active] 698971005303 serine O-acetyltransferase; Region: cysE; TIGR01172 698971005304 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 698971005305 trimer interface [polypeptide binding]; other site 698971005306 active site 698971005307 substrate binding site [chemical binding]; other site 698971005308 CoA binding site [chemical binding]; other site 698971005309 Predicted acetyltransferase [General function prediction only]; Region: COG2388 698971005310 Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171 698971005311 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 698971005312 putative active site [active] 698971005313 metal binding site [ion binding]; metal-binding site 698971005314 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698971005315 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698971005316 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 698971005317 DNA methylase; Region: N6_N4_Mtase; pfam01555 698971005318 DNA methylase; Region: N6_N4_Mtase; pfam01555 698971005319 HTH-like domain; Region: HTH_21; pfam13276 698971005320 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 698971005321 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 698971005322 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 698971005323 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 698971005324 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 698971005325 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698971005326 Walker A/P-loop; other site 698971005327 ATP binding site [chemical binding]; other site 698971005328 Q-loop/lid; other site 698971005329 ABC transporter signature motif; other site 698971005330 Walker B; other site 698971005331 D-loop; other site 698971005332 H-loop/switch region; other site 698971005333 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 698971005334 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698971005335 Walker A/P-loop; other site 698971005336 ATP binding site [chemical binding]; other site 698971005337 Q-loop/lid; other site 698971005338 ABC transporter signature motif; other site 698971005339 Walker B; other site 698971005340 D-loop; other site 698971005341 H-loop/switch region; other site 698971005342 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 698971005343 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 698971005344 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 698971005345 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 698971005346 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 698971005347 FMN binding site [chemical binding]; other site 698971005348 active site 698971005349 catalytic residues [active] 698971005350 substrate binding site [chemical binding]; other site 698971005351 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 698971005352 PhoU domain; Region: PhoU; pfam01895 698971005353 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 698971005354 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 698971005355 Walker A/P-loop; other site 698971005356 ATP binding site [chemical binding]; other site 698971005357 Q-loop/lid; other site 698971005358 ABC transporter signature motif; other site 698971005359 Walker B; other site 698971005360 D-loop; other site 698971005361 H-loop/switch region; other site 698971005362 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 698971005363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698971005364 dimer interface [polypeptide binding]; other site 698971005365 conserved gate region; other site 698971005366 putative PBP binding loops; other site 698971005367 ABC-ATPase subunit interface; other site 698971005368 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 698971005369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698971005370 dimer interface [polypeptide binding]; other site 698971005371 conserved gate region; other site 698971005372 putative PBP binding loops; other site 698971005373 ABC-ATPase subunit interface; other site 698971005374 PBP superfamily domain; Region: PBP_like_2; cl17296 698971005375 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 698971005376 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698971005377 Coenzyme A binding pocket [chemical binding]; other site 698971005378 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698971005379 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 698971005380 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 698971005381 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 698971005382 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 698971005383 heme-binding site [chemical binding]; other site 698971005384 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 698971005385 substrate binding site [chemical binding]; other site 698971005386 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 698971005387 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 698971005388 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698971005389 catalytic residue [active] 698971005390 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 698971005391 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 698971005392 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 698971005393 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 698971005394 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 698971005395 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 698971005396 dimerization interface [polypeptide binding]; other site 698971005397 putative ATP binding site [chemical binding]; other site 698971005398 amidophosphoribosyltransferase; Provisional; Region: PRK07847 698971005399 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 698971005400 active site 698971005401 tetramer interface [polypeptide binding]; other site 698971005402 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698971005403 active site 698971005404 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 698971005405 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 698971005406 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 698971005407 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 698971005408 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 698971005409 dimer interface [polypeptide binding]; other site 698971005410 putative radical transfer pathway; other site 698971005411 diiron center [ion binding]; other site 698971005412 tyrosyl radical; other site 698971005413 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 698971005414 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 698971005415 catalytic residues [active] 698971005416 dimer interface [polypeptide binding]; other site 698971005417 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 698971005418 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698971005419 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 698971005420 ATP binding site [chemical binding]; other site 698971005421 active site 698971005422 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 698971005423 substrate binding site [chemical binding]; other site 698971005424 adenylosuccinate lyase; Region: purB; TIGR00928 698971005425 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 698971005426 tetramer interface [polypeptide binding]; other site 698971005427 aspartate aminotransferase; Provisional; Region: PRK05764 698971005428 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698971005429 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698971005430 homodimer interface [polypeptide binding]; other site 698971005431 catalytic residue [active] 698971005432 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 698971005433 TrkA-N domain; Region: TrkA_N; pfam02254 698971005434 TrkA-C domain; Region: TrkA_C; pfam02080 698971005435 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 698971005436 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 698971005437 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 698971005438 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 698971005439 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 698971005440 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 698971005441 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 698971005442 nucleotide binding site/active site [active] 698971005443 HIT family signature motif; other site 698971005444 catalytic residue [active] 698971005445 PGAP1-like protein; Region: PGAP1; pfam07819 698971005446 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698971005447 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698971005448 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698971005449 dimerization interface [polypeptide binding]; other site 698971005450 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698971005451 dimer interface [polypeptide binding]; other site 698971005452 phosphorylation site [posttranslational modification] 698971005453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698971005454 ATP binding site [chemical binding]; other site 698971005455 Mg2+ binding site [ion binding]; other site 698971005456 G-X-G motif; other site 698971005457 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698971005458 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698971005459 active site 698971005460 phosphorylation site [posttranslational modification] 698971005461 intermolecular recognition site; other site 698971005462 dimerization interface [polypeptide binding]; other site 698971005463 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698971005464 DNA binding site [nucleotide binding] 698971005465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698971005466 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698971005467 putative substrate translocation pore; other site 698971005468 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698971005469 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698971005470 xanthine permease; Region: pbuX; TIGR03173 698971005471 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 698971005472 pyruvate dehydrogenase; Provisional; Region: PRK06546 698971005473 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 698971005474 PYR/PP interface [polypeptide binding]; other site 698971005475 dimer interface [polypeptide binding]; other site 698971005476 tetramer interface [polypeptide binding]; other site 698971005477 TPP binding site [chemical binding]; other site 698971005478 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698971005479 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 698971005480 TPP-binding site [chemical binding]; other site 698971005481 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698971005482 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 698971005483 Uncharacterized conserved protein [Function unknown]; Region: COG2966 698971005484 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698971005485 Uncharacterized conserved protein [Function unknown]; Region: COG3610 698971005486 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 698971005487 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 698971005488 active site 698971005489 homotetramer interface [polypeptide binding]; other site 698971005490 META domain; Region: META; cl01245 698971005491 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 698971005492 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 698971005493 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698971005494 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698971005495 DNA binding site [nucleotide binding] 698971005496 domain linker motif; other site 698971005497 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 698971005498 putative dimerization interface [polypeptide binding]; other site 698971005499 putative ligand binding site [chemical binding]; other site 698971005500 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698971005501 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 698971005502 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698971005503 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 698971005504 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698971005505 active site 698971005506 HIGH motif; other site 698971005507 nucleotide binding site [chemical binding]; other site 698971005508 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 698971005509 KMSKS motif; other site 698971005510 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 698971005511 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 698971005512 homotrimer interaction site [polypeptide binding]; other site 698971005513 zinc binding site [ion binding]; other site 698971005514 CDP-binding sites; other site 698971005515 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 698971005516 substrate binding site; other site 698971005517 dimer interface; other site 698971005518 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 698971005519 DNA repair protein RadA; Provisional; Region: PRK11823 698971005520 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 698971005521 Walker A motif; other site 698971005522 ATP binding site [chemical binding]; other site 698971005523 Walker B motif; other site 698971005524 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 698971005525 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 698971005526 active site clefts [active] 698971005527 zinc binding site [ion binding]; other site 698971005528 dimer interface [polypeptide binding]; other site 698971005529 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698971005530 endonuclease III; Region: ENDO3c; smart00478 698971005531 minor groove reading motif; other site 698971005532 helix-hairpin-helix signature motif; other site 698971005533 substrate binding pocket [chemical binding]; other site 698971005534 active site 698971005535 Uncharacterized conserved protein [Function unknown]; Region: COG2966 698971005536 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698971005537 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 698971005538 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 698971005539 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 698971005540 Clp amino terminal domain; Region: Clp_N; pfam02861 698971005541 Clp amino terminal domain; Region: Clp_N; pfam02861 698971005542 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698971005543 Walker A motif; other site 698971005544 ATP binding site [chemical binding]; other site 698971005545 Walker B motif; other site 698971005546 arginine finger; other site 698971005547 UvrB/uvrC motif; Region: UVR; pfam02151 698971005548 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698971005549 Walker A motif; other site 698971005550 ATP binding site [chemical binding]; other site 698971005551 Walker B motif; other site 698971005552 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 698971005553 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 698971005554 oligomer interface [polypeptide binding]; other site 698971005555 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698971005556 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698971005557 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 698971005558 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 698971005559 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 698971005560 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 698971005561 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 698971005562 active site 698971005563 catalytic motif [active] 698971005564 Zn binding site [ion binding]; other site 698971005565 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 698971005566 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 698971005567 Nucleoside recognition; Region: Gate; pfam07670 698971005568 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 698971005569 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 698971005570 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 698971005571 dimer interface [polypeptide binding]; other site 698971005572 putative anticodon binding site; other site 698971005573 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698971005574 motif 1; other site 698971005575 dimer interface [polypeptide binding]; other site 698971005576 active site 698971005577 motif 2; other site 698971005578 motif 3; other site 698971005579 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698971005580 YcaO-like family; Region: YcaO; pfam02624 698971005581 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698971005582 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698971005583 Walker A/P-loop; other site 698971005584 ATP binding site [chemical binding]; other site 698971005585 Q-loop/lid; other site 698971005586 ABC transporter signature motif; other site 698971005587 Walker B; other site 698971005588 D-loop; other site 698971005589 H-loop/switch region; other site 698971005590 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 698971005591 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 698971005592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 698971005593 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 698971005594 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 698971005595 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698971005596 active site 698971005597 KMSKS motif; other site 698971005598 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 698971005599 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 698971005600 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 698971005601 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 698971005602 catalytic center binding site [active] 698971005603 ATP binding site [chemical binding]; other site 698971005604 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 698971005605 homooctamer interface [polypeptide binding]; other site 698971005606 active site 698971005607 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 698971005608 dihydropteroate synthase; Region: DHPS; TIGR01496 698971005609 substrate binding pocket [chemical binding]; other site 698971005610 dimer interface [polypeptide binding]; other site 698971005611 inhibitor binding site; inhibition site 698971005612 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 698971005613 homodecamer interface [polypeptide binding]; other site 698971005614 GTP cyclohydrolase I; Provisional; Region: PLN03044 698971005615 active site 698971005616 putative catalytic site residues [active] 698971005617 zinc binding site [ion binding]; other site 698971005618 GTP-CH-I/GFRP interaction surface; other site 698971005619 FtsH Extracellular; Region: FtsH_ext; pfam06480 698971005620 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 698971005621 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698971005622 Walker A motif; other site 698971005623 ATP binding site [chemical binding]; other site 698971005624 Walker B motif; other site 698971005625 arginine finger; other site 698971005626 Peptidase family M41; Region: Peptidase_M41; pfam01434 698971005627 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698971005628 active site 698971005629 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 698971005630 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 698971005631 Ligand Binding Site [chemical binding]; other site 698971005632 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 698971005633 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 698971005634 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 698971005635 dimer interface [polypeptide binding]; other site 698971005636 substrate binding site [chemical binding]; other site 698971005637 metal binding sites [ion binding]; metal-binding site 698971005638 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698971005639 active site residue [active] 698971005640 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698971005641 MarR family; Region: MarR_2; pfam12802 698971005642 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698971005643 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 698971005644 acyl-activating enzyme (AAE) consensus motif; other site 698971005645 AMP binding site [chemical binding]; other site 698971005646 active site 698971005647 CoA binding site [chemical binding]; other site 698971005648 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698971005649 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 698971005650 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698971005651 putative trimer interface [polypeptide binding]; other site 698971005652 putative CoA binding site [chemical binding]; other site 698971005653 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698971005654 putative trimer interface [polypeptide binding]; other site 698971005655 putative CoA binding site [chemical binding]; other site 698971005656 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698971005657 metal ion-dependent adhesion site (MIDAS); other site 698971005658 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698971005659 active site 698971005660 catalytic site [active] 698971005661 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 698971005662 Secretory lipase; Region: LIP; pfam03583 698971005663 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 698971005664 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 698971005665 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 698971005666 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 698971005667 ring oligomerisation interface [polypeptide binding]; other site 698971005668 ATP/Mg binding site [chemical binding]; other site 698971005669 stacking interactions; other site 698971005670 hinge regions; other site 698971005671 Fic/DOC family; Region: Fic; pfam02661 698971005672 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 698971005673 hypothetical protein; Reviewed; Region: PRK09588 698971005674 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698971005675 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 698971005676 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 698971005677 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 698971005678 FMN binding site [chemical binding]; other site 698971005679 active site 698971005680 substrate binding site [chemical binding]; other site 698971005681 catalytic residue [active] 698971005682 intracellular protease, PfpI family; Region: PfpI; TIGR01382 698971005683 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 698971005684 proposed catalytic triad [active] 698971005685 conserved cys residue [active] 698971005686 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 698971005687 G4 box; other site 698971005688 G5 box; other site 698971005689 hypothetical protein; Provisional; Region: PRK07907 698971005690 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 698971005691 active site 698971005692 metal binding site [ion binding]; metal-binding site 698971005693 dimer interface [polypeptide binding]; other site 698971005694 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 698971005695 carboxylate-amine ligase; Provisional; Region: PRK13517 698971005696 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 698971005697 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 698971005698 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 698971005699 active site 698971005700 catalytic residues [active] 698971005701 metal binding site [ion binding]; metal-binding site 698971005702 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 698971005703 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698971005704 Coenzyme A binding pocket [chemical binding]; other site 698971005705 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 698971005706 putative catalytic site [active] 698971005707 putative metal binding site [ion binding]; other site 698971005708 putative phosphate binding site [ion binding]; other site 698971005709 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 698971005710 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 698971005711 putative active site [active] 698971005712 catalytic site [active] 698971005713 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 698971005714 putative active site [active] 698971005715 catalytic site [active] 698971005716 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 698971005717 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698971005718 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698971005719 Walker A/P-loop; other site 698971005720 ATP binding site [chemical binding]; other site 698971005721 Q-loop/lid; other site 698971005722 ABC transporter signature motif; other site 698971005723 Walker B; other site 698971005724 D-loop; other site 698971005725 H-loop/switch region; other site 698971005726 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698971005727 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698971005728 substrate binding pocket [chemical binding]; other site 698971005729 membrane-bound complex binding site; other site 698971005730 hinge residues; other site 698971005731 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698971005732 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698971005733 active site 698971005734 ATP binding site [chemical binding]; other site 698971005735 substrate binding site [chemical binding]; other site 698971005736 activation loop (A-loop); other site 698971005737 propionate/acetate kinase; Provisional; Region: PRK12379 698971005738 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 698971005739 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 698971005740 ferredoxin-NADP+ reductase; Region: PLN02852 698971005741 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698971005742 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698971005743 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 698971005744 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698971005745 active site 698971005746 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698971005747 putative active site [active] 698971005748 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 698971005749 Cna protein B-type domain; Region: Cna_B; pfam05738 698971005750 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 698971005751 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 698971005752 GDP-binding site [chemical binding]; other site 698971005753 ACT binding site; other site 698971005754 IMP binding site; other site 698971005755 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698971005756 conserved repeat domain; Region: B_ant_repeat; TIGR01451 698971005757 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 698971005758 Predicted membrane protein [Function unknown]; Region: COG4129 698971005759 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 698971005760 Predicted membrane protein [Function unknown]; Region: COG4129 698971005761 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 698971005762 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 698971005763 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 698971005764 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 698971005765 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698971005766 Transposase; Region: HTH_Tnp_1; pfam01527 698971005767 HTH-like domain; Region: HTH_21; pfam13276 698971005768 Integrase core domain; Region: rve_3; pfam13683 698971005769 Abi-like protein; Region: Abi_2; cl01988 698971005770 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 698971005771 DNA-binding site [nucleotide binding]; DNA binding site 698971005772 potential frameshift: common BLAST hit: gi|68535552|ref|YP_250257.1| transposase IS3510c 698971005773 potential frameshift: common BLAST hit: gi|38234642|ref|NP_940409.1| Sdr family related adhesin 698971005774 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 698971005775 Cna protein B-type domain; Region: Cna_B; pfam05738 698971005776 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 698971005777 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 698971005778 active site 698971005779 intersubunit interface [polypeptide binding]; other site 698971005780 zinc binding site [ion binding]; other site 698971005781 Na+ binding site [ion binding]; other site 698971005782 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 698971005783 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698971005784 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698971005785 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698971005786 active site 698971005787 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 698971005788 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 698971005789 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698971005790 active site residue [active] 698971005791 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 698971005792 active site residue [active] 698971005793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698971005794 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 698971005795 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 698971005796 Clp amino terminal domain; Region: Clp_N; pfam02861 698971005797 Clp amino terminal domain; Region: Clp_N; pfam02861 698971005798 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698971005799 Walker A motif; other site 698971005800 ATP binding site [chemical binding]; other site 698971005801 Walker B motif; other site 698971005802 arginine finger; other site 698971005803 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698971005804 Walker A motif; other site 698971005805 ATP binding site [chemical binding]; other site 698971005806 Walker B motif; other site 698971005807 arginine finger; other site 698971005808 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 698971005809 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 698971005810 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 698971005811 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698971005812 Walker A/P-loop; other site 698971005813 ATP binding site [chemical binding]; other site 698971005814 Q-loop/lid; other site 698971005815 ABC transporter signature motif; other site 698971005816 Walker B; other site 698971005817 D-loop; other site 698971005818 H-loop/switch region; other site 698971005819 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 698971005820 EamA-like transporter family; Region: EamA; pfam00892 698971005821 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698971005822 EamA-like transporter family; Region: EamA; pfam00892 698971005823 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 698971005824 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 698971005825 FAD binding pocket [chemical binding]; other site 698971005826 FAD binding motif [chemical binding]; other site 698971005827 phosphate binding motif [ion binding]; other site 698971005828 beta-alpha-beta structure motif; other site 698971005829 NAD binding pocket [chemical binding]; other site 698971005830 Predicted amidohydrolase [General function prediction only]; Region: COG0388 698971005831 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 698971005832 putative active site [active] 698971005833 catalytic triad [active] 698971005834 putative dimer interface [polypeptide binding]; other site 698971005835 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 698971005836 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 698971005837 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 698971005838 NAD binding site [chemical binding]; other site 698971005839 substrate binding site [chemical binding]; other site 698971005840 catalytic Zn binding site [ion binding]; other site 698971005841 tetramer interface [polypeptide binding]; other site 698971005842 structural Zn binding site [ion binding]; other site 698971005843 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 698971005844 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698971005845 NAD(P) binding site [chemical binding]; other site 698971005846 catalytic residues [active] 698971005847 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 698971005848 DNA binding residues [nucleotide binding] 698971005849 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698971005850 putative dimer interface [polypeptide binding]; other site 698971005851 chaperone protein DnaJ; Provisional; Region: PRK14279 698971005852 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698971005853 HSP70 interaction site [polypeptide binding]; other site 698971005854 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 698971005855 Zn binding sites [ion binding]; other site 698971005856 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 698971005857 dimer interface [polypeptide binding]; other site 698971005858 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 698971005859 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 698971005860 dimer interface [polypeptide binding]; other site 698971005861 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 698971005862 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 698971005863 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 698971005864 nucleotide binding site [chemical binding]; other site 698971005865 NEF interaction site [polypeptide binding]; other site 698971005866 SBD interface [polypeptide binding]; other site 698971005867 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698971005868 PAS domain; Region: PAS_9; pfam13426 698971005869 putative active site [active] 698971005870 heme pocket [chemical binding]; other site 698971005871 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698971005872 Domain of unknown function DUF20; Region: UPF0118; pfam01594 698971005873 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698971005874 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698971005875 Walker A/P-loop; other site 698971005876 ATP binding site [chemical binding]; other site 698971005877 Q-loop/lid; other site 698971005878 ABC transporter signature motif; other site 698971005879 Walker B; other site 698971005880 D-loop; other site 698971005881 H-loop/switch region; other site 698971005882 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698971005883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698971005884 dimer interface [polypeptide binding]; other site 698971005885 conserved gate region; other site 698971005886 putative PBP binding loops; other site 698971005887 ABC-ATPase subunit interface; other site 698971005888 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698971005889 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 698971005890 Walker A/P-loop; other site 698971005891 ATP binding site [chemical binding]; other site 698971005892 Q-loop/lid; other site 698971005893 ABC transporter signature motif; other site 698971005894 Walker B; other site 698971005895 D-loop; other site 698971005896 H-loop/switch region; other site 698971005897 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698971005898 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698971005899 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698971005900 dimer interface [polypeptide binding]; other site 698971005901 conserved gate region; other site 698971005902 putative PBP binding loops; other site 698971005903 ABC-ATPase subunit interface; other site 698971005904 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698971005905 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 698971005906 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 698971005907 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 698971005908 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 698971005909 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 698971005910 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 698971005911 dimerization interface [polypeptide binding]; other site 698971005912 ATP binding site [chemical binding]; other site 698971005913 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 698971005914 dimerization interface [polypeptide binding]; other site 698971005915 ATP binding site [chemical binding]; other site 698971005916 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 698971005917 putative active site [active] 698971005918 catalytic triad [active] 698971005919 nucleosidase; Provisional; Region: PRK05634 698971005920 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 698971005921 ferredoxin-NADP+ reductase; Region: PLN02852 698971005922 Permease; Region: Permease; cl00510 698971005923 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 698971005924 4Fe-4S binding domain; Region: Fer4; cl02805 698971005925 Cysteine-rich domain; Region: CCG; pfam02754 698971005926 Cysteine-rich domain; Region: CCG; pfam02754 698971005927 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 698971005928 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 698971005929 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 698971005930 putative NAD(P) binding site [chemical binding]; other site 698971005931 catalytic Zn binding site [ion binding]; other site 698971005932 aminotransferase AlaT; Validated; Region: PRK09265 698971005933 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698971005934 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698971005935 homodimer interface [polypeptide binding]; other site 698971005936 catalytic residue [active] 698971005937 YibE/F-like protein; Region: YibE_F; pfam07907 698971005938 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 698971005939 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 698971005940 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 698971005941 dimer interface [polypeptide binding]; other site 698971005942 putative anticodon binding site; other site 698971005943 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698971005944 motif 1; other site 698971005945 dimer interface [polypeptide binding]; other site 698971005946 active site 698971005947 motif 2; other site 698971005948 motif 3; other site 698971005949 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698971005950 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698971005951 Protein of unknown function (DUF998); Region: DUF998; pfam06197 698971005952 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 698971005953 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 698971005954 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 698971005955 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 698971005956 trimer interface [polypeptide binding]; other site 698971005957 active site 698971005958 BRO family, N-terminal domain; Region: Bro-N; smart01040 698971005959 Abi-like protein; Region: Abi_2; cl01988 698971005960 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 698971005961 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698971005962 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698971005963 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698971005964 Walker A/P-loop; other site 698971005965 ATP binding site [chemical binding]; other site 698971005966 Q-loop/lid; other site 698971005967 ABC transporter signature motif; other site 698971005968 Walker B; other site 698971005969 D-loop; other site 698971005970 H-loop/switch region; other site 698971005971 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698971005972 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698971005973 Walker A/P-loop; other site 698971005974 ATP binding site [chemical binding]; other site 698971005975 Q-loop/lid; other site 698971005976 ABC transporter signature motif; other site 698971005977 Walker B; other site 698971005978 D-loop; other site 698971005979 H-loop/switch region; other site 698971005980 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 698971005981 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 698971005982 active site 698971005983 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 698971005984 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698971005985 Condensation domain; Region: Condensation; pfam00668 698971005986 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698971005987 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698971005988 Condensation domain; Region: Condensation; pfam00668 698971005989 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698971005990 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698971005991 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698971005992 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 698971005993 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698971005994 Condensation domain; Region: Condensation; pfam00668 698971005995 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698971005996 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 698971005997 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 698971005998 acyl-activating enzyme (AAE) consensus motif; other site 698971005999 AMP binding site [chemical binding]; other site 698971006000 Condensation domain; Region: Condensation; pfam00668 698971006001 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698971006002 Phosphopantetheine attachment site; Region: PP-binding; cl09936 698971006003 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698971006004 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 698971006005 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698971006006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698971006007 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698971006008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698971006009 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698971006010 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 698971006011 Walker A/P-loop; other site 698971006012 ATP binding site [chemical binding]; other site 698971006013 Q-loop/lid; other site 698971006014 ABC transporter signature motif; other site 698971006015 Walker B; other site 698971006016 D-loop; other site 698971006017 H-loop/switch region; other site 698971006018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698971006019 Walker A/P-loop; other site 698971006020 ATP binding site [chemical binding]; other site 698971006021 Q-loop/lid; other site 698971006022 ABC transporter signature motif; other site 698971006023 Walker B; other site 698971006024 D-loop; other site 698971006025 H-loop/switch region; other site 698971006026 metabolite-proton symporter; Region: 2A0106; TIGR00883 698971006027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698971006028 putative substrate translocation pore; other site 698971006029 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 698971006030 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 698971006031 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 698971006032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698971006033 putative substrate translocation pore; other site 698971006034 YwiC-like protein; Region: YwiC; pfam14256 698971006035 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 698971006036 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 698971006037 VanW like protein; Region: VanW; pfam04294 698971006038 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 698971006039 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 698971006040 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 698971006041 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698971006042 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 698971006043 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698971006044 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698971006045 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698971006046 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698971006047 S-adenosylmethionine binding site [chemical binding]; other site 698971006048 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 698971006049 active site 698971006050 substrate-binding site [chemical binding]; other site 698971006051 metal-binding site [ion binding] 698971006052 GTP binding site [chemical binding]; other site 698971006053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698971006054 S-adenosylmethionine binding site [chemical binding]; other site 698971006055 LabA_like proteins; Region: LabA_like; cd06167 698971006056 putative metal binding site [ion binding]; other site 698971006057 MMPL family; Region: MMPL; pfam03176 698971006058 Protein of unknown function (DUF496); Region: DUF496; cl09955 698971006059 MMPL family; Region: MMPL; pfam03176 698971006060 Predicted integral membrane protein [Function unknown]; Region: COG0392 698971006061 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 698971006062 Fibronectin-binding protein signal sequence; Region: Fb_signal; pfam08341 698971006063 TQXA domain; Region: TQXA_dom; TIGR03934 698971006064 potential frameshift: common BLAST hit: gi|337291728|ref|YP_004630749.1| protease CP40 698971006065 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 698971006066 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 698971006067 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698971006068 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698971006069 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698971006070 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 698971006071 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 698971006072 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 698971006073 active site 698971006074 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 698971006075 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 698971006076 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 698971006077 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 698971006078 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 698971006079 acyl-activating enzyme (AAE) consensus motif; other site 698971006080 active site 698971006081 Cutinase; Region: Cutinase; pfam01083 698971006082 Putative esterase; Region: Esterase; pfam00756 698971006083 S-formylglutathione hydrolase; Region: PLN02442 698971006084 LGFP repeat; Region: LGFP; pfam08310 698971006085 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 698971006086 LGFP repeat; Region: LGFP; pfam08310 698971006087 LGFP repeat; Region: LGFP; pfam08310 698971006088 Predicted esterase [General function prediction only]; Region: COG0627 698971006089 S-formylglutathione hydrolase; Region: PLN02442 698971006090 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 698971006091 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 698971006092 UbiA prenyltransferase family; Region: UbiA; pfam01040 698971006093 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 698971006094 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698971006095 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 698971006096 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 698971006097 active site 698971006098 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 698971006099 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698971006100 NAD(P) binding site [chemical binding]; other site 698971006101 catalytic residues [active] 698971006102 BCCT family transporter; Region: BCCT; cl00569 698971006103 choline dehydrogenase; Validated; Region: PRK02106 698971006104 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 698971006105 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 698971006106 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698971006107 UDP-galactopyranose mutase; Region: GLF; pfam03275 698971006108 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 698971006109 Firmicute plasmid replication protein (RepL); Region: RepL; pfam05732 698971006110 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 698971006111 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698971006112 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698971006113 ABC transporter signature motif; other site 698971006114 Walker B; other site 698971006115 D-loop; other site 698971006116 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 698971006117 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 698971006118 amidase catalytic site [active] 698971006119 Zn binding residues [ion binding]; other site 698971006120 substrate binding site [chemical binding]; other site 698971006121 LGFP repeat; Region: LGFP; pfam08310 698971006122 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 698971006123 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698971006124 Integrase core domain; Region: rve; pfam00665 698971006125 Protein P3 of Potyviral polyprotein; Region: Potyvirid-P3; pfam13608 698971006126 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698971006127 active site 698971006128 catalytic site [active] 698971006129 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698971006130 active site 698971006131 catalytic site [active] 698971006132 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 698971006133 Cna protein B-type domain; Region: Cna_B; pfam05738 698971006134 Cna protein B-type domain; Region: Cna_B; pfam05738 698971006135 Cna protein B-type domain; Region: Cna_B; pfam05738 698971006136 Cna protein B-type domain; Region: Cna_B; pfam05738 698971006137 Cna protein B-type domain; Region: Cna_B; pfam05738 698971006138 Cna protein B-type domain; Region: Cna_B; pfam05738 698971006139 HTH-like domain; Region: HTH_21; pfam13276 698971006140 Integrase core domain; Region: rve; pfam00665 698971006141 glycerol kinase; Provisional; Region: glpK; PRK00047 698971006142 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 698971006143 N- and C-terminal domain interface [polypeptide binding]; other site 698971006144 active site 698971006145 MgATP binding site [chemical binding]; other site 698971006146 catalytic site [active] 698971006147 metal binding site [ion binding]; metal-binding site 698971006148 putative homotetramer interface [polypeptide binding]; other site 698971006149 glycerol binding site [chemical binding]; other site 698971006150 homodimer interface [polypeptide binding]; other site 698971006151 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 698971006152 amphipathic channel; other site 698971006153 Asn-Pro-Ala signature motifs; other site 698971006154 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 698971006155 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 698971006156 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 698971006157 putative acyl-acceptor binding pocket; other site 698971006158 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698971006159 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698971006160 active site 698971006161 motif I; other site 698971006162 motif II; other site 698971006163 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698971006164 seryl-tRNA synthetase; Provisional; Region: PRK05431 698971006165 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 698971006166 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 698971006167 dimer interface [polypeptide binding]; other site 698971006168 active site 698971006169 motif 1; other site 698971006170 motif 2; other site 698971006171 motif 3; other site 698971006172 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 698971006173 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698971006174 DNA-binding site [nucleotide binding]; DNA binding site 698971006175 UTRA domain; Region: UTRA; pfam07702 698971006176 Septum formation; Region: Septum_form; pfam13845 698971006177 Septum formation; Region: Septum_form; pfam13845 698971006178 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 698971006179 AAA domain; Region: AAA_14; pfam13173 698971006180 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 698971006181 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698971006182 catalytic core [active] 698971006183 prephenate dehydratase; Provisional; Region: PRK11898 698971006184 Prephenate dehydratase; Region: PDT; pfam00800 698971006185 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 698971006186 putative L-Phe binding site [chemical binding]; other site 698971006187 Amidase; Region: Amidase; cl11426 698971006188 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 698971006189 CAAX protease self-immunity; Region: Abi; pfam02517 698971006190 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 698971006191 Transcriptional regulator [Transcription]; Region: LytR; COG1316 698971006192 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 698971006193 amino acid carrier protein; Region: agcS; TIGR00835 698971006194 Acyltransferase family; Region: Acyl_transf_3; pfam01757 698971006195 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 698971006196 catalytic triad [active] 698971006197 catalytic triad [active] 698971006198 oxyanion hole [active] 698971006199 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 698971006200 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 698971006201 putative active site [active] 698971006202 catalytic site [active] 698971006203 putative metal binding site [ion binding]; other site 698971006204 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 698971006205 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 698971006206 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698971006207 NAD binding site [chemical binding]; other site 698971006208 dimer interface [polypeptide binding]; other site 698971006209 substrate binding site [chemical binding]; other site 698971006210 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 698971006211 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 698971006212 motif I; other site 698971006213 active site 698971006214 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698971006215 motif II; other site 698971006216 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698971006217 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 698971006218 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 698971006219 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 698971006220 Predicted flavoprotein [General function prediction only]; Region: COG0431 698971006221 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698971006222 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 698971006223 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 698971006224 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 698971006225 Lsr2; Region: Lsr2; pfam11774 698971006226 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698971006227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698971006228 active site 698971006229 phosphorylation site [posttranslational modification] 698971006230 intermolecular recognition site; other site 698971006231 dimerization interface [polypeptide binding]; other site 698971006232 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698971006233 DNA binding residues [nucleotide binding] 698971006234 dimerization interface [polypeptide binding]; other site 698971006235 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698971006236 Histidine kinase; Region: HisKA_3; pfam07730 698971006237 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698971006238 ATP binding site [chemical binding]; other site 698971006239 Mg2+ binding site [ion binding]; other site 698971006240 G-X-G motif; other site 698971006241 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 698971006242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698971006243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698971006244 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 698971006245 active site 698971006246 catalytic site [active] 698971006247 putative inner membrane protein translocase component YidC; Validated; Region: PRK00247 698971006248 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 698971006249 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698971006250 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698971006251 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698971006252 Ligand Binding Site [chemical binding]; other site 698971006253 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698971006254 Ligand Binding Site [chemical binding]; other site 698971006255 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 698971006256 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 698971006257 probable active site [active] 698971006258 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698971006259 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698971006260 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698971006261 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698971006262 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698971006263 Walker A/P-loop; other site 698971006264 ATP binding site [chemical binding]; other site 698971006265 Q-loop/lid; other site 698971006266 ABC transporter signature motif; other site 698971006267 Walker B; other site 698971006268 D-loop; other site 698971006269 H-loop/switch region; other site 698971006270 Predicted transcriptional regulators [Transcription]; Region: COG1725 698971006271 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698971006272 DNA-binding site [nucleotide binding]; DNA binding site 698971006273 LabA_like proteins; Region: LabA_like; cd06167 698971006274 putative metal binding site [ion binding]; other site 698971006275 Uncharacterized conserved protein [Function unknown]; Region: COG1432 698971006276 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 698971006277 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698971006278 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698971006279 catalytic residues [active] 698971006280 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698971006281 metal-binding site [ion binding] 698971006282 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 698971006283 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698971006284 metal-binding site [ion binding] 698971006285 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698971006286 Soluble P-type ATPase [General function prediction only]; Region: COG4087 698971006287 benzoate transport; Region: 2A0115; TIGR00895 698971006288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698971006289 putative substrate translocation pore; other site 698971006290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698971006291 replicative DNA helicase; Provisional; Region: PRK05636 698971006292 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 698971006293 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 698971006294 Walker A motif; other site 698971006295 ATP binding site [chemical binding]; other site 698971006296 Walker B motif; other site 698971006297 DNA binding loops [nucleotide binding] 698971006298 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 698971006299 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 698971006300 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 698971006301 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 698971006302 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698971006303 dimer interface [polypeptide binding]; other site 698971006304 ssDNA binding site [nucleotide binding]; other site 698971006305 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698971006306 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 698971006307 Predicted integral membrane protein [Function unknown]; Region: COG5650 698971006308 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 698971006309 Transglycosylase; Region: Transgly; pfam00912 698971006310 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698971006311 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698971006312 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698971006313 Ligand Binding Site [chemical binding]; other site 698971006314 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698971006315 Ligand Binding Site [chemical binding]; other site 698971006316 classical (c) SDRs; Region: SDR_c; cd05233 698971006317 short chain dehydrogenase; Provisional; Region: PRK08219 698971006318 NAD(P) binding site [chemical binding]; other site 698971006319 active site 698971006320 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698971006321 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698971006322 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 698971006323 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 698971006324 active site residue [active] 698971006325 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 698971006326 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 698971006327 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 698971006328 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 698971006329 dimerization interface [polypeptide binding]; other site 698971006330 DPS ferroxidase diiron center [ion binding]; other site 698971006331 ion pore; other site 698971006332 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 698971006333 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 698971006334 putative DNA binding site [nucleotide binding]; other site 698971006335 catalytic residue [active] 698971006336 putative H2TH interface [polypeptide binding]; other site 698971006337 putative catalytic residues [active] 698971006338 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698971006339 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 698971006340 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 698971006341 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 698971006342 putative substrate binding site [chemical binding]; other site 698971006343 putative ATP binding site [chemical binding]; other site 698971006344 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 698971006345 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 698971006346 active site 698971006347 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 698971006348 AAA domain; Region: AAA_31; pfam13614 698971006349 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698971006350 P-loop; other site 698971006351 Magnesium ion binding site [ion binding]; other site 698971006352 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698971006353 Magnesium ion binding site [ion binding]; other site 698971006354 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698971006355 Divergent AAA domain; Region: AAA_4; pfam04326 698971006356 Divergent AAA domain; Region: AAA_4; pfam04326 698971006357 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698971006358 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698971006359 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698971006360 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 698971006361 Walker A motif; other site 698971006362 ATP binding site [chemical binding]; other site 698971006363 Walker B motif; other site 698971006364 arginine finger; other site 698971006365 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698971006366 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698971006367 ATP binding site [chemical binding]; other site 698971006368 putative Mg++ binding site [ion binding]; other site 698971006369 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 698971006370 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698971006371 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 698971006372 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 698971006373 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698971006374 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698971006375 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 698971006376 HsdM N-terminal domain; Region: HsdM_N; pfam12161 698971006377 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 698971006378 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698971006379 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698971006380 non-specific DNA binding site [nucleotide binding]; other site 698971006381 salt bridge; other site 698971006382 sequence-specific DNA binding site [nucleotide binding]; other site 698971006383 AAA domain; Region: AAA_23; pfam13476 698971006384 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698971006385 Walker A/P-loop; other site 698971006386 ATP binding site [chemical binding]; other site 698971006387 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 698971006388 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 698971006389 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 698971006390 Abi-like protein; Region: Abi_2; pfam07751 698971006391 Uncharacterized conserved protein [Function unknown]; Region: COG3410 698971006392 Fic family protein [Function unknown]; Region: COG3177 698971006393 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 698971006394 Fic/DOC family; Region: Fic; pfam02661 698971006395 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 698971006396 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 698971006397 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 698971006398 E-class dimer interface [polypeptide binding]; other site 698971006399 P-class dimer interface [polypeptide binding]; other site 698971006400 active site 698971006401 Cu2+ binding site [ion binding]; other site 698971006402 Zn2+ binding site [ion binding]; other site 698971006403 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 698971006404 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698971006405 active site 698971006406 HIGH motif; other site 698971006407 nucleotide binding site [chemical binding]; other site 698971006408 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 698971006409 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698971006410 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698971006411 active site 698971006412 KMSKS motif; other site 698971006413 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 698971006414 tRNA binding surface [nucleotide binding]; other site 698971006415 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698971006416 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698971006417 Walker A/P-loop; other site 698971006418 ATP binding site [chemical binding]; other site 698971006419 Q-loop/lid; other site 698971006420 ABC transporter signature motif; other site 698971006421 Walker B; other site 698971006422 D-loop; other site 698971006423 H-loop/switch region; other site 698971006424 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698971006425 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698971006426 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698971006427 Histidine kinase; Region: HisKA_3; pfam07730 698971006428 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 698971006429 ATP binding site [chemical binding]; other site 698971006430 G-X-G motif; other site 698971006431 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698971006432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698971006433 active site 698971006434 phosphorylation site [posttranslational modification] 698971006435 intermolecular recognition site; other site 698971006436 dimerization interface [polypeptide binding]; other site 698971006437 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698971006438 DNA binding residues [nucleotide binding] 698971006439 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 698971006440 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 698971006441 Predicted membrane protein [Function unknown]; Region: COG1511 698971006442 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698971006443 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698971006444 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698971006445 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 698971006446 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 698971006447 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698971006448 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 698971006449 NAD(P) binding site [chemical binding]; other site 698971006450 catalytic residues [active] 698971006451 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 698971006452 active site 698971006453 phosphorylation site [posttranslational modification] 698971006454 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 698971006455 active site 698971006456 P-loop; other site 698971006457 phosphorylation site [posttranslational modification] 698971006458 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 698971006459 Putative esterase; Region: Esterase; pfam00756 698971006460 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 698971006461 active site 698971006462 Cobalt transport protein; Region: CbiQ; cl00463 698971006463 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698971006464 ABC transporter signature motif; other site 698971006465 Walker B; other site 698971006466 D-loop; other site 698971006467 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 698971006468 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698971006469 Walker A/P-loop; other site 698971006470 ATP binding site [chemical binding]; other site 698971006471 Q-loop/lid; other site 698971006472 ABC transporter signature motif; other site 698971006473 Walker B; other site 698971006474 D-loop; other site 698971006475 H-loop/switch region; other site 698971006476 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 698971006477 active site 698971006478 catalytic residues [active] 698971006479 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 698971006480 hypothetical protein; Provisional; Region: PRK13663 698971006481 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698971006482 putative active site [active] 698971006483 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 698971006484 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 698971006485 SdpI/YhfL protein family; Region: SdpI; pfam13630 698971006486 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 698971006487 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 698971006488 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698971006489 catalytic residue [active] 698971006490 potential frameshift: common BLAST hit: gi|38234886|ref|NP_940653.1| anthranilate synthase component I 698971006491 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 698971006492 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698971006493 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 698971006494 Glutamine amidotransferase class-I; Region: GATase; pfam00117 698971006495 glutamine binding [chemical binding]; other site 698971006496 catalytic triad [active] 698971006497 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 698971006498 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 698971006499 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 698971006500 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 698971006501 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 698971006502 active site 698971006503 ribulose/triose binding site [chemical binding]; other site 698971006504 phosphate binding site [ion binding]; other site 698971006505 substrate (anthranilate) binding pocket [chemical binding]; other site 698971006506 product (indole) binding pocket [chemical binding]; other site 698971006507 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 698971006508 active site 698971006509 Protein of unknown function (DUF454); Region: DUF454; cl01063 698971006510 pantoate--beta-alanine ligase; Region: panC; TIGR00018 698971006511 Pantoate-beta-alanine ligase; Region: PanC; cd00560 698971006512 active site 698971006513 ATP-binding site [chemical binding]; other site 698971006514 pantoate-binding site; other site 698971006515 HXXH motif; other site 698971006516 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 698971006517 oligomerization interface [polypeptide binding]; other site 698971006518 active site 698971006519 metal binding site [ion binding]; metal-binding site 698971006520 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 698971006521 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 698971006522 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698971006523 catalytic residue [active] 698971006524 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 698971006525 substrate binding site [chemical binding]; other site 698971006526 active site 698971006527 catalytic residues [active] 698971006528 heterodimer interface [polypeptide binding]; other site 698971006529 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 698971006530 iron-sulfur cluster [ion binding]; other site 698971006531 [2Fe-2S] cluster binding site [ion binding]; other site 698971006532 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 698971006533 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 698971006534 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 698971006535 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 698971006536 hypothetical protein; Validated; Region: PRK00228 698971006537 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 698971006538 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 698971006539 active site 698971006540 NTP binding site [chemical binding]; other site 698971006541 metal binding triad [ion binding]; metal-binding site 698971006542 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 698971006543 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698971006544 Zn2+ binding site [ion binding]; other site 698971006545 Mg2+ binding site [ion binding]; other site 698971006546 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 698971006547 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 698971006548 active site 698971006549 Ap6A binding site [chemical binding]; other site 698971006550 nudix motif; other site 698971006551 metal binding site [ion binding]; metal-binding site 698971006552 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 698971006553 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 698971006554 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 698971006555 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698971006556 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698971006557 DNA binding residues [nucleotide binding] 698971006558 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 698971006559 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698971006560 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698971006561 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698971006562 catalytic residues [active] 698971006563 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698971006564 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698971006565 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 698971006566 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 698971006567 active site 698971006568 metal binding site [ion binding]; metal-binding site 698971006569 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 698971006570 ParB-like nuclease domain; Region: ParBc; pfam02195 698971006571 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 698971006572 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698971006573 P-loop; other site 698971006574 Magnesium ion binding site [ion binding]; other site 698971006575 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698971006576 Magnesium ion binding site [ion binding]; other site 698971006577 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 698971006578 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 698971006579 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 698971006580 ribonuclease P; Reviewed; Region: rnpA; PRK03459 698971006581 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399