-- dump date   	20140619_051402
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1204414000001	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
1204414000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1204414000003	Walker A motif; other site
1204414000004	ATP binding site [chemical binding]; other site
1204414000005	Walker B motif; other site
1204414000006	arginine finger; other site
1204414000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1204414000008	DnaA box-binding interface [nucleotide binding]; other site
1204414000009	DNA polymerase III subunit beta; Validated; Region: PRK07761
1204414000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1204414000011	putative DNA binding surface [nucleotide binding]; other site
1204414000012	dimer interface [polypeptide binding]; other site
1204414000013	beta-clamp/clamp loader binding surface; other site
1204414000014	beta-clamp/translesion DNA polymerase binding surface; other site
1204414000015	recombination protein F; Reviewed; Region: recF; PRK00064
1204414000016	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
1204414000017	Walker A/P-loop; other site
1204414000018	ATP binding site [chemical binding]; other site
1204414000019	Q-loop/lid; other site
1204414000020	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414000021	ABC transporter signature motif; other site
1204414000022	Walker B; other site
1204414000023	D-loop; other site
1204414000024	H-loop/switch region; other site
1204414000025	hypothetical protein; Provisional; Region: PRK00111
1204414000026	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1204414000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1204414000028	ATP binding site [chemical binding]; other site
1204414000029	Mg2+ binding site [ion binding]; other site
1204414000030	G-X-G motif; other site
1204414000031	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1204414000032	anchoring element; other site
1204414000033	dimer interface [polypeptide binding]; other site
1204414000034	ATP binding site [chemical binding]; other site
1204414000035	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1204414000036	active site
1204414000037	putative metal-binding site [ion binding]; other site
1204414000038	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1204414000039	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
1204414000040	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1204414000041	Predicted membrane protein [Function unknown]; Region: COG2364
1204414000042	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1204414000043	DNA gyrase subunit A; Validated; Region: PRK05560
1204414000044	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1204414000045	CAP-like domain; other site
1204414000046	active site
1204414000047	primary dimer interface [polypeptide binding]; other site
1204414000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1204414000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1204414000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1204414000051	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1204414000052	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1204414000053	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1204414000054	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
1204414000055	Predicted membrane protein [Function unknown]; Region: COG2855
1204414000056	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1204414000057	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1204414000058	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1204414000059	dimerization interface [polypeptide binding]; other site
1204414000060	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1204414000061	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1204414000062	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1204414000063	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1204414000064	Predicted transcriptional regulator [Transcription]; Region: COG3682
1204414000065	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
1204414000066	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1204414000067	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1204414000068	active site
1204414000069	metal binding site [ion binding]; metal-binding site
1204414000070	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1204414000071	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
1204414000072	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
1204414000073	Divergent AAA domain; Region: AAA_4; pfam04326
1204414000074	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
1204414000075	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
1204414000076	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1204414000077	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1204414000078	intersubunit interface [polypeptide binding]; other site
1204414000079	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1204414000080	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1204414000081	ABC-ATPase subunit  interface; other site
1204414000082	dimer interface [polypeptide binding]; other site
1204414000083	putative PBP binding regions; other site
1204414000084	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1204414000085	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414000086	Walker A/P-loop; other site
1204414000087	ATP binding site [chemical binding]; other site
1204414000088	Q-loop/lid; other site
1204414000089	ABC transporter signature motif; other site
1204414000090	Walker B; other site
1204414000091	D-loop; other site
1204414000092	H-loop/switch region; other site
1204414000093	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
1204414000094	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1204414000095	putative ligand binding site [chemical binding]; other site
1204414000096	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1204414000097	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1204414000098	TM-ABC transporter signature motif; other site
1204414000099	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1204414000100	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1204414000101	Walker A/P-loop; other site
1204414000102	ATP binding site [chemical binding]; other site
1204414000103	Q-loop/lid; other site
1204414000104	ABC transporter signature motif; other site
1204414000105	Walker B; other site
1204414000106	D-loop; other site
1204414000107	H-loop/switch region; other site
1204414000108	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
1204414000109	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1204414000110	active site
1204414000111	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
1204414000112	Helix-turn-helix domain; Region: HTH_18; pfam12833
1204414000113	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1204414000114	Helix-turn-helix domain; Region: HTH_18; pfam12833
1204414000115	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1204414000116	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1204414000117	dimer interface [polypeptide binding]; other site
1204414000118	putative PBP binding regions; other site
1204414000119	ABC-ATPase subunit  interface; other site
1204414000120	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1204414000121	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1204414000122	Walker A/P-loop; other site
1204414000123	ATP binding site [chemical binding]; other site
1204414000124	Q-loop/lid; other site
1204414000125	ABC transporter signature motif; other site
1204414000126	Walker B; other site
1204414000127	D-loop; other site
1204414000128	H-loop/switch region; other site
1204414000129	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
1204414000130	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
1204414000131	FAD binding pocket [chemical binding]; other site
1204414000132	FAD binding motif [chemical binding]; other site
1204414000133	phosphate binding motif [ion binding]; other site
1204414000134	NAD binding pocket [chemical binding]; other site
1204414000135	putative septation inhibitor protein; Reviewed; Region: PRK00159
1204414000136	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1204414000137	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1204414000138	active site
1204414000139	ATP binding site [chemical binding]; other site
1204414000140	substrate binding site [chemical binding]; other site
1204414000141	activation loop (A-loop); other site
1204414000142	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
1204414000143	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1204414000144	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1204414000145	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1204414000146	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
1204414000147	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1204414000148	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1204414000149	active site
1204414000150	ATP binding site [chemical binding]; other site
1204414000151	substrate binding site [chemical binding]; other site
1204414000152	activation loop (A-loop); other site
1204414000153	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1204414000154	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1204414000155	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1204414000156	Protein phosphatase 2C; Region: PP2C; pfam00481
1204414000157	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1204414000158	active site
1204414000159	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1204414000160	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1204414000161	phosphopeptide binding site; other site
1204414000162	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
1204414000163	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1204414000164	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1204414000165	phosphopeptide binding site; other site
1204414000166	succinic semialdehyde dehydrogenase; Region: PLN02278
1204414000167	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1204414000168	tetramerization interface [polypeptide binding]; other site
1204414000169	NAD(P) binding site [chemical binding]; other site
1204414000170	catalytic residues [active]
1204414000171	FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979
1204414000172	dimer interface [polypeptide binding]; other site
1204414000173	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1204414000174	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1204414000175	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1204414000176	active site residue [active]
1204414000177	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1204414000178	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1204414000179	active site residue [active]
1204414000180	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1204414000181	active site residue [active]
1204414000182	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
1204414000183	putative homodimer interface [polypeptide binding]; other site
1204414000184	putative homotetramer interface [polypeptide binding]; other site
1204414000185	putative allosteric switch controlling residues; other site
1204414000186	putative metal binding site [ion binding]; other site
1204414000187	putative homodimer-homodimer interface [polypeptide binding]; other site
1204414000188	Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750
1204414000189	putative metal binding residues [ion binding]; other site
1204414000190	signature motif; other site
1204414000191	dimer interface [polypeptide binding]; other site
1204414000192	active site
1204414000193	polyP binding site; other site
1204414000194	substrate binding site [chemical binding]; other site
1204414000195	acceptor-phosphate pocket; other site
1204414000196	MgtC family; Region: MgtC; pfam02308
1204414000197	CotH protein; Region: CotH; pfam08757
1204414000198	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1204414000199	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
1204414000200	oligomer interface [polypeptide binding]; other site
1204414000201	metal binding site [ion binding]; metal-binding site
1204414000202	metal binding site [ion binding]; metal-binding site
1204414000203	putative Cl binding site [ion binding]; other site
1204414000204	basic sphincter; other site
1204414000205	hydrophobic gate; other site
1204414000206	periplasmic entrance; other site
1204414000207	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
1204414000208	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1204414000209	dimer interface [polypeptide binding]; other site
1204414000210	hexamer interface [polypeptide binding]; other site
1204414000211	active site 2 [active]
1204414000212	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1204414000213	Putative ClC chloride channel.  Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033
1204414000214	putative ion selectivity filter; other site
1204414000215	putative pore gating glutamate residue; other site
1204414000216	Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201
1204414000217	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
1204414000218	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
1204414000219	putative active site [active]
1204414000220	PhoH-like protein; Region: PhoH; pfam02562
1204414000221	H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620
1204414000222	Citrate transporter; Region: CitMHS; pfam03600
1204414000223	H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620
1204414000224	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1204414000225	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1204414000226	ATP binding site [chemical binding]; other site
1204414000227	Mg2+ binding site [ion binding]; other site
1204414000228	G-X-G motif; other site
1204414000229	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
1204414000230	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1204414000231	active site
1204414000232	phosphorylation site [posttranslational modification]
1204414000233	intermolecular recognition site; other site
1204414000234	dimerization interface [polypeptide binding]; other site
1204414000235	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1204414000236	putative DNA binding site [nucleotide binding]; other site
1204414000237	putative Zn2+ binding site [ion binding]; other site
1204414000238	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1204414000239	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159
1204414000240	putative ligand binding site [chemical binding]; other site
1204414000241	putative NAD binding site [chemical binding]; other site
1204414000242	catalytic site [active]
1204414000243	biotin synthase; Validated; Region: PRK06256
1204414000244	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1204414000245	FeS/SAM binding site; other site
1204414000246	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
1204414000247	Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357
1204414000248	CHY zinc finger; Region: zf-CHY; pfam05495
1204414000249	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1204414000250	cytosine deaminase; Provisional; Region: PRK09230
1204414000251	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
1204414000252	active site
1204414000253	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
1204414000254	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
1204414000255	Lipase (class 2); Region: Lipase_2; pfam01674
1204414000256	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
1204414000257	Lipase (class 2); Region: Lipase_2; pfam01674
1204414000258	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1204414000259	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1204414000260	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
1204414000261	alpha-gamma subunit interface [polypeptide binding]; other site
1204414000262	beta-gamma subunit interface [polypeptide binding]; other site
1204414000263	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
1204414000264	gamma-beta subunit interface [polypeptide binding]; other site
1204414000265	alpha-beta subunit interface [polypeptide binding]; other site
1204414000266	urease subunit alpha; Reviewed; Region: ureC; PRK13207
1204414000267	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
1204414000268	subunit interactions [polypeptide binding]; other site
1204414000269	active site
1204414000270	flap region; other site
1204414000271	Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371
1204414000272	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
1204414000273	dimer interface [polypeptide binding]; other site
1204414000274	catalytic residues [active]
1204414000275	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
1204414000276	Region: UreF; pfam01730
1204414000277	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1204414000278	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
1204414000279	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1204414000280	HSP90 family protein; Provisional; Region: PRK14083
1204414000281	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1204414000282	ATP binding site [chemical binding]; other site
1204414000283	Mg2+ binding site [ion binding]; other site
1204414000284	G-X-G motif; other site
1204414000285	AMP nucleosidase; Region: AMP-nucleosdse; TIGR01717
1204414000286	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
1204414000287	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
1204414000288	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
1204414000289	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1204414000290	PYR/PP interface [polypeptide binding]; other site
1204414000291	dimer interface [polypeptide binding]; other site
1204414000292	TPP binding site [chemical binding]; other site
1204414000293	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
1204414000294	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1204414000295	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1204414000296	NAD(P) binding site [chemical binding]; other site
1204414000297	catalytic residues [active]
1204414000298	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1204414000299	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1204414000300	active site
1204414000301	catalytic tetrad [active]
1204414000302	Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978
1204414000303	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
1204414000304	amidohydrolase; Region: amidohydrolases; TIGR01891
1204414000305	metal binding site [ion binding]; metal-binding site
1204414000306	Predicted membrane protein [Function unknown]; Region: COG2149
1204414000307	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1204414000308	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1204414000309	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1204414000310	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
1204414000311	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1204414000312	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1204414000313	catalytic core [active]
1204414000314	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
1204414000315	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1204414000316	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1204414000317	polyol permease family; Region: 2A0118; TIGR00897
1204414000318	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414000319	putative substrate translocation pore; other site
1204414000320	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1204414000321	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1204414000322	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1204414000323	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1204414000324	D-xylulose kinase; Region: XylB; TIGR01312
1204414000325	nucleotide binding site [chemical binding]; other site
1204414000326	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1204414000327	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1204414000328	active site
1204414000329	ATP-binding site [chemical binding]; other site
1204414000330	pantoate-binding site; other site
1204414000331	HXXH motif; other site
1204414000332	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1204414000333	oligomerization interface [polypeptide binding]; other site
1204414000334	active site
1204414000335	metal binding site [ion binding]; metal-binding site
1204414000336	Fic family protein [Function unknown]; Region: COG3177
1204414000337	Fic/DOC family; Region: Fic; pfam02661
1204414000338	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
1204414000339	active site
1204414000340	DNA binding site [nucleotide binding]
1204414000341	hypothetical protein; Provisional; Region: PRK07758
1204414000342	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
1204414000343	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1204414000344	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1204414000345	substrate binding pocket [chemical binding]; other site
1204414000346	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1204414000347	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1204414000348	motif II; other site
1204414000349	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1204414000350	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1204414000351	trimer interface [polypeptide binding]; other site
1204414000352	putative metal binding site [ion binding]; other site
1204414000353	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1204414000354	putative DNA binding site [nucleotide binding]; other site
1204414000355	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1204414000356	enterobactin exporter EntS; Provisional; Region: PRK10489
1204414000357	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414000358	putative substrate translocation pore; other site
1204414000359	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
1204414000360	CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427
1204414000361	DXD motif; other site
1204414000362	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
1204414000363	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1204414000364	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1204414000365	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
1204414000366	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1204414000367	Predicted permeases [General function prediction only]; Region: RarD; COG2962
1204414000368	Predicted membrane protein [Function unknown]; Region: COG2860
1204414000369	UPF0126 domain; Region: UPF0126; pfam03458
1204414000370	UPF0126 domain; Region: UPF0126; pfam03458
1204414000371	Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187
1204414000372	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
1204414000373	tetramerization interface [polypeptide binding]; other site
1204414000374	active site
1204414000375	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805
1204414000376	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
1204414000377	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1204414000378	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1204414000379	hypothetical protein; Provisional; Region: PRK10621
1204414000380	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1204414000381	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
1204414000382	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1204414000383	putative Mg++ binding site [ion binding]; other site
1204414000384	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1204414000385	nucleotide binding region [chemical binding]; other site
1204414000386	ATP-binding site [chemical binding]; other site
1204414000387	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
1204414000388	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1204414000389	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
1204414000390	maltose O-acetyltransferase; Provisional; Region: PRK10092
1204414000391	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1204414000392	active site
1204414000393	substrate binding site [chemical binding]; other site
1204414000394	trimer interface [polypeptide binding]; other site
1204414000395	CoA binding site [chemical binding]; other site
1204414000396	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
1204414000397	3-methyladenine DNA glycosylase [DNA replication, recombination, and repair]; Region: Tag; COG2818
1204414000398	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1204414000399	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1204414000400	RNA binding surface [nucleotide binding]; other site
1204414000401	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1204414000402	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1204414000403	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1204414000404	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1204414000405	DNA binding site [nucleotide binding]
1204414000406	active site
1204414000407	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1204414000408	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1204414000409	homotrimer interaction site [polypeptide binding]; other site
1204414000410	putative active site [active]
1204414000411	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
1204414000412	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
1204414000413	active site
1204414000414	Zn binding site [ion binding]; other site
1204414000415	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
1204414000416	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1204414000417	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1204414000418	DNA-binding site [nucleotide binding]; DNA binding site
1204414000419	UTRA domain; Region: UTRA; pfam07702
1204414000420	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1204414000421	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1204414000422	substrate binding site [chemical binding]; other site
1204414000423	ATP binding site [chemical binding]; other site
1204414000424	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1204414000425	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1204414000426	tetrameric interface [polypeptide binding]; other site
1204414000427	NAD binding site [chemical binding]; other site
1204414000428	catalytic residues [active]
1204414000429	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
1204414000430	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
1204414000431	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1204414000432	PYR/PP interface [polypeptide binding]; other site
1204414000433	dimer interface [polypeptide binding]; other site
1204414000434	TPP binding site [chemical binding]; other site
1204414000435	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1204414000436	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
1204414000437	TPP-binding site; other site
1204414000438	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1204414000439	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1204414000440	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1204414000441	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1204414000442	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1204414000443	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414000444	putative transporter; Provisional; Region: PRK10504
1204414000445	putative substrate translocation pore; other site
1204414000446	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1204414000447	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1204414000448	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1204414000449	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
1204414000450	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1204414000451	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1204414000452	DNA binding site [nucleotide binding]
1204414000453	domain linker motif; other site
1204414000454	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1204414000455	dimerization interface [polypeptide binding]; other site
1204414000456	ligand binding site [chemical binding]; other site
1204414000457	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1204414000458	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1204414000459	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1204414000460	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1204414000461	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1204414000462	DNA-binding site [nucleotide binding]; DNA binding site
1204414000463	RNA-binding motif; other site
1204414000464	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1204414000465	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
1204414000466	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1204414000467	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1204414000468	S-adenosylmethionine binding site [chemical binding]; other site
1204414000469	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1204414000470	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1204414000471	Coenzyme A binding pocket [chemical binding]; other site
1204414000472	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1204414000473	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1204414000474	DNA binding site [nucleotide binding]
1204414000475	domain linker motif; other site
1204414000476	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1204414000477	dimerization interface [polypeptide binding]; other site
1204414000478	ligand binding site [chemical binding]; other site
1204414000479	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
1204414000480	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414000481	putative substrate translocation pore; other site
1204414000482	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414000483	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1204414000484	Helix-turn-helix domain; Region: HTH_38; pfam13936
1204414000485	Homeodomain-like domain; Region: HTH_32; pfam13565
1204414000486	Integrase core domain; Region: rve; pfam00665
1204414000487	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1204414000488	PAS domain; Region: PAS_9; pfam13426
1204414000489	putative active site [active]
1204414000490	heme pocket [chemical binding]; other site
1204414000491	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1204414000492	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1204414000493	active site
1204414000494	dimer interface [polypeptide binding]; other site
1204414000495	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1204414000496	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1204414000497	active site
1204414000498	FMN binding site [chemical binding]; other site
1204414000499	substrate binding site [chemical binding]; other site
1204414000500	3Fe-4S cluster binding site [ion binding]; other site
1204414000501	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1204414000502	domain interface; other site
1204414000503	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
1204414000504	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1204414000505	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
1204414000506	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
1204414000507	Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250
1204414000508	Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249
1204414000509	short chain dehydrogenase; Provisional; Region: PRK07904
1204414000510	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1204414000511	NAD(P) binding site [chemical binding]; other site
1204414000512	active site
1204414000513	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1204414000514	FAD binding domain; Region: FAD_binding_4; pfam01565
1204414000515	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
1204414000516	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
1204414000517	Predicted membrane protein [Function unknown]; Region: COG2246
1204414000518	GtrA-like protein; Region: GtrA; pfam04138
1204414000519	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
1204414000520	MOSC domain; Region: MOSC; pfam03473
1204414000521	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1204414000522	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1204414000523	active site
1204414000524	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
1204414000525	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1204414000526	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1204414000527	Walker A/P-loop; other site
1204414000528	ATP binding site [chemical binding]; other site
1204414000529	Q-loop/lid; other site
1204414000530	ABC transporter signature motif; other site
1204414000531	Walker B; other site
1204414000532	D-loop; other site
1204414000533	H-loop/switch region; other site
1204414000534	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1204414000535	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1204414000536	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1204414000537	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1204414000538	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
1204414000539	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
1204414000540	NAD(P) binding site [chemical binding]; other site
1204414000541	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1204414000542	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1204414000543	catalytic loop [active]
1204414000544	iron binding site [ion binding]; other site
1204414000545	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1204414000546	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
1204414000547	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1204414000548	molybdopterin biosynthesis protein MoeB; Validated; Region: PRK05597
1204414000549	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1204414000550	ATP binding site [chemical binding]; other site
1204414000551	substrate interface [chemical binding]; other site
1204414000552	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1204414000553	active site residue [active]
1204414000554	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1204414000555	MoaE homodimer interface [polypeptide binding]; other site
1204414000556	MoaD interaction [polypeptide binding]; other site
1204414000557	active site residues [active]
1204414000558	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1204414000559	MPT binding site; other site
1204414000560	trimer interface [polypeptide binding]; other site
1204414000561	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1204414000562	trimer interface [polypeptide binding]; other site
1204414000563	dimer interface [polypeptide binding]; other site
1204414000564	putative active site [active]
1204414000565	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1204414000566	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1204414000567	dimer interface [polypeptide binding]; other site
1204414000568	putative functional site; other site
1204414000569	putative MPT binding site; other site
1204414000570	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1204414000571	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1204414000572	dimer interface [polypeptide binding]; other site
1204414000573	conserved gate region; other site
1204414000574	putative PBP binding loops; other site
1204414000575	ABC-ATPase subunit interface; other site
1204414000576	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1204414000577	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1204414000578	Ubiquitin-like proteins; Region: UBQ; cl00155
1204414000579	charged pocket; other site
1204414000580	hydrophobic patch; other site
1204414000581	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1204414000582	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1204414000583	Walker A/P-loop; other site
1204414000584	ATP binding site [chemical binding]; other site
1204414000585	Q-loop/lid; other site
1204414000586	ABC transporter signature motif; other site
1204414000587	Walker B; other site
1204414000588	D-loop; other site
1204414000589	H-loop/switch region; other site
1204414000590	Predicted membrane protein [Function unknown]; Region: COG1950
1204414000591	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
1204414000592	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1204414000593	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1204414000594	homodimer interface [polypeptide binding]; other site
1204414000595	catalytic residue [active]
1204414000596	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
1204414000597	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1204414000598	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1204414000599	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1204414000600	dimerization interface [polypeptide binding]; other site
1204414000601	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1204414000602	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296
1204414000603	putative NAD(P) binding site [chemical binding]; other site
1204414000604	putative substrate binding site [chemical binding]; other site
1204414000605	catalytic Zn binding site [ion binding]; other site
1204414000606	structural Zn binding site [ion binding]; other site
1204414000607	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
1204414000608	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1204414000609	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1204414000610	MgtE intracellular N domain; Region: MgtE_N; smart00924
1204414000611	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1204414000612	Divalent cation transporter; Region: MgtE; cl00786
1204414000613	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1204414000614	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
1204414000615	transmembrane helices; other site
1204414000616	prephenate dehydrogenase; Validated; Region: PRK06545
1204414000617	prephenate dehydrogenase; Validated; Region: PRK08507
1204414000618	putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941
1204414000619	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1204414000620	nucleoside/Zn binding site; other site
1204414000621	dimer interface [polypeptide binding]; other site
1204414000622	catalytic motif [active]
1204414000623	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
1204414000624	MMPL family; Region: MMPL; pfam03176
1204414000625	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1204414000626	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
1204414000627	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
1204414000628	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1204414000629	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1204414000630	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414000631	Q-loop/lid; other site
1204414000632	ABC transporter signature motif; other site
1204414000633	Walker B; other site
1204414000634	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
1204414000635	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
1204414000636	active site
1204414000637	HIGH motif; other site
1204414000638	nucleotide binding site [chemical binding]; other site
1204414000639	active site
1204414000640	KMSKS motif; other site
1204414000641	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
1204414000642	Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to  the...; Region: intradiol_dioxygenase_like; cd03457
1204414000643	putative active site [active]
1204414000644	Integrase core domain; Region: rve; pfam00665
1204414000645	DDE domain; Region: DDE_Tnp_IS240; pfam13610
1204414000646	Integrase core domain; Region: rve_3; pfam13683
1204414000647	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
1204414000648	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1204414000649	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1204414000650	homodimer interface [polypeptide binding]; other site
1204414000651	catalytic residue [active]
1204414000652	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
1204414000653	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
1204414000654	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1204414000655	Walker A motif; other site
1204414000656	ATP binding site [chemical binding]; other site
1204414000657	Walker B motif; other site
1204414000658	arginine finger; other site
1204414000659	hypothetical protein; Validated; Region: PRK00153
1204414000660	recombination protein RecR; Reviewed; Region: recR; PRK00076
1204414000661	Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278
1204414000662	RecR protein; Region: RecR; pfam02132
1204414000663	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1204414000664	putative active site [active]
1204414000665	putative metal-binding site [ion binding]; other site
1204414000666	tetramer interface [polypeptide binding]; other site
1204414000667	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1204414000668	catalytic triad [active]
1204414000669	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
1204414000670	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1204414000671	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
1204414000672	DNA polymerase III subunit epsilon; Validated; Region: PRK05601
1204414000673	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1204414000674	2-isopropylmalate synthase; Validated; Region: PRK03739
1204414000675	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
1204414000676	active site
1204414000677	catalytic residues [active]
1204414000678	metal binding site [ion binding]; metal-binding site
1204414000679	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
1204414000680	aspartate kinase; Reviewed; Region: PRK06635
1204414000681	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
1204414000682	putative nucleotide binding site [chemical binding]; other site
1204414000683	putative catalytic residues [active]
1204414000684	putative Mg ion binding site [ion binding]; other site
1204414000685	putative aspartate binding site [chemical binding]; other site
1204414000686	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
1204414000687	putative allosteric regulatory site; other site
1204414000688	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
1204414000689	putative allosteric regulatory residue; other site
1204414000690	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1204414000691	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1204414000692	RNA polymerase sigma factor; Provisional; Region: PRK12535
1204414000693	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1204414000694	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1204414000695	DNA binding residues [nucleotide binding]
1204414000696	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1204414000697	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
1204414000698	heme binding pocket [chemical binding]; other site
1204414000699	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1204414000700	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1204414000701	AsnC family; Region: AsnC_trans_reg; pfam01037
1204414000702	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
1204414000703	Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687
1204414000704	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1204414000705	dimerization interface [polypeptide binding]; other site
1204414000706	putative DNA binding site [nucleotide binding]; other site
1204414000707	putative Zn2+ binding site [ion binding]; other site
1204414000708	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
1204414000709	arsenical-resistance protein; Region: acr3; TIGR00832
1204414000710	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1204414000711	Low molecular weight phosphatase family; Region: LMWPc; cl00105
1204414000712	active site
1204414000713	Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism]; Region: MnhG; COG1320
1204414000714	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612
1204414000715	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654
1204414000716	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
1204414000717	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1204414000718	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375
1204414000719	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650
1204414000720	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1204414000721	Domain of unknown function (DUF4040); Region: DUF4040; pfam13244
1204414000722	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
1204414000723	Predicted membrane protein [Function unknown]; Region: COG1511
1204414000724	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1204414000725	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1204414000726	active site
1204414000727	phosphorylation site [posttranslational modification]
1204414000728	intermolecular recognition site; other site
1204414000729	dimerization interface [polypeptide binding]; other site
1204414000730	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1204414000731	DNA binding site [nucleotide binding]
1204414000732	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1204414000733	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1204414000734	dimerization interface [polypeptide binding]; other site
1204414000735	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1204414000736	dimer interface [polypeptide binding]; other site
1204414000737	phosphorylation site [posttranslational modification]
1204414000738	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1204414000739	ATP binding site [chemical binding]; other site
1204414000740	Mg2+ binding site [ion binding]; other site
1204414000741	G-X-G motif; other site
1204414000742	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1204414000743	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1204414000744	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1204414000745	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1204414000746	putative active site [active]
1204414000747	putative metal binding site [ion binding]; other site
1204414000748	Yqey-like protein; Region: YqeY; pfam09424
1204414000749	Transglycosylase; Region: Transgly; pfam00912
1204414000750	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1204414000751	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1204414000752	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1204414000753	Transcription factor WhiB; Region: Whib; pfam02467
1204414000754	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
1204414000755	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
1204414000756	homotrimer interaction site [polypeptide binding]; other site
1204414000757	putative active site [active]
1204414000758	metabolite-proton symporter; Region: 2A0106; TIGR00883
1204414000759	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414000760	putative substrate translocation pore; other site
1204414000761	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
1204414000762	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1204414000763	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
1204414000764	acyl-activating enzyme (AAE) consensus motif; other site
1204414000765	acyl-activating enzyme (AAE) consensus motif; other site
1204414000766	putative AMP binding site [chemical binding]; other site
1204414000767	putative active site [active]
1204414000768	putative CoA binding site [chemical binding]; other site
1204414000769	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1204414000770	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1204414000771	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1204414000772	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1204414000773	NAD(P) binding site [chemical binding]; other site
1204414000774	active site
1204414000775	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
1204414000776	active site
1204414000777	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1204414000778	acyl-coenzyme A oxidase; Region: PLN02526
1204414000779	active site
1204414000780	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
1204414000781	putative active site [active]
1204414000782	putative catalytic site [active]
1204414000783	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1204414000784	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1204414000785	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1204414000786	ligand binding site [chemical binding]; other site
1204414000787	flexible hinge region; other site
1204414000788	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1204414000789	putative switch regulator; other site
1204414000790	non-specific DNA interactions [nucleotide binding]; other site
1204414000791	DNA binding site [nucleotide binding]
1204414000792	sequence specific DNA binding site [nucleotide binding]; other site
1204414000793	putative cAMP binding site [chemical binding]; other site
1204414000794	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1204414000795	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1204414000796	minor groove reading motif; other site
1204414000797	helix-hairpin-helix signature motif; other site
1204414000798	substrate binding pocket [chemical binding]; other site
1204414000799	active site
1204414000800	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1204414000801	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1204414000802	catalytic residues [active]
1204414000803	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
1204414000804	putative active site [active]
1204414000805	putative CoA binding site [chemical binding]; other site
1204414000806	nudix motif; other site
1204414000807	metal binding site [ion binding]; metal-binding site
1204414000808	Colicin V production protein; Region: Colicin_V; pfam02674
1204414000809	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1204414000810	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1204414000811	active site
1204414000812	substrate binding sites [chemical binding]; other site
1204414000813	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1204414000814	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1204414000815	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
1204414000816	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1204414000817	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1204414000818	motif II; other site
1204414000819	helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815
1204414000820	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
1204414000821	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1204414000822	ATP binding site [chemical binding]; other site
1204414000823	Walker A motif; other site
1204414000824	hexamer interface [polypeptide binding]; other site
1204414000825	Walker B motif; other site
1204414000826	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
1204414000827	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1204414000828	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
1204414000829	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1204414000830	Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
1204414000831	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
1204414000832	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1204414000833	ATP binding site [chemical binding]; other site
1204414000834	putative Mg++ binding site [ion binding]; other site
1204414000835	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
1204414000836	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1204414000837	DNA-binding site [nucleotide binding]; DNA binding site
1204414000838	RNA-binding motif; other site
1204414000839	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
1204414000840	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1204414000841	active site
1204414000842	interdomain interaction site; other site
1204414000843	putative metal-binding site [ion binding]; other site
1204414000844	nucleotide binding site [chemical binding]; other site
1204414000845	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1204414000846	domain I; other site
1204414000847	DNA binding groove [nucleotide binding]
1204414000848	phosphate binding site [ion binding]; other site
1204414000849	domain II; other site
1204414000850	domain III; other site
1204414000851	nucleotide binding site [chemical binding]; other site
1204414000852	catalytic site [active]
1204414000853	domain IV; other site
1204414000854	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1204414000855	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1204414000856	YhhN-like protein; Region: YhhN; pfam07947
1204414000857	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1204414000858	dimerization interface [polypeptide binding]; other site
1204414000859	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1204414000860	cyclase homology domain; Region: CHD; cd07302
1204414000861	nucleotidyl binding site; other site
1204414000862	metal binding site [ion binding]; metal-binding site
1204414000863	dimer interface [polypeptide binding]; other site
1204414000864	DNA polymerase III subunit delta'; Validated; Region: PRK07940
1204414000865	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1204414000866	Walker A motif; other site
1204414000867	ATP binding site [chemical binding]; other site
1204414000868	Walker B motif; other site
1204414000869	arginine finger; other site
1204414000870	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
1204414000871	Uncharacterized phage-associated protein [Function unknown]; Region: GepA; COG3600
1204414000872	Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563
1204414000873	AAA domain; Region: AAA_17; pfam13207
1204414000874	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1204414000875	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1204414000876	RNA binding surface [nucleotide binding]; other site
1204414000877	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1204414000878	active site
1204414000879	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1204414000880	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
1204414000881	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1204414000882	S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451
1204414000883	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
1204414000884	NAD binding site [chemical binding]; other site
1204414000885	catalytic Zn binding site [ion binding]; other site
1204414000886	substrate binding site [chemical binding]; other site
1204414000887	structural Zn binding site [ion binding]; other site
1204414000888	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1204414000889	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1204414000890	classical (c) SDRs; Region: SDR_c; cd05233
1204414000891	NAD(P) binding site [chemical binding]; other site
1204414000892	active site
1204414000893	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414000894	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1204414000895	putative substrate translocation pore; other site
1204414000896	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1204414000897	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1204414000898	NAD(P) binding site [chemical binding]; other site
1204414000899	active site
1204414000900	Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034
1204414000901	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
1204414000902	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1204414000903	Ligand binding site; other site
1204414000904	Putative Catalytic site; other site
1204414000905	DXD motif; other site
1204414000906	Ribonuclease HI [DNA replication, recombination, and repair]; Region: RnhA; COG0328
1204414000907	RNA/DNA hybrid binding site [nucleotide binding]; other site
1204414000908	active site
1204414000909	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1204414000910	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
1204414000911	Probable Catalytic site; other site
1204414000912	metal-binding site
1204414000913	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1204414000914	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
1204414000915	putative active site [active]
1204414000916	putative metal binding site [ion binding]; other site
1204414000917	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1204414000918	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1204414000919	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
1204414000920	putative NAD(P) binding site [chemical binding]; other site
1204414000921	putative substrate binding site [chemical binding]; other site
1204414000922	catalytic Zn binding site [ion binding]; other site
1204414000923	structural Zn binding site [ion binding]; other site
1204414000924	dimer interface [polypeptide binding]; other site
1204414000925	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1204414000926	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1204414000927	substrate binding site; other site
1204414000928	tetramer interface; other site
1204414000929	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
1204414000930	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
1204414000931	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1204414000932	NADP binding site [chemical binding]; other site
1204414000933	active site
1204414000934	putative substrate binding site [chemical binding]; other site
1204414000935	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1204414000936	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1204414000937	NAD binding site [chemical binding]; other site
1204414000938	substrate binding site [chemical binding]; other site
1204414000939	homodimer interface [polypeptide binding]; other site
1204414000940	active site
1204414000941	NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370
1204414000942	dimer interface [polypeptide binding]; other site
1204414000943	FMN binding site [chemical binding]; other site
1204414000944	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1204414000945	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1204414000946	siderophore binding site; other site
1204414000947	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
1204414000948	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
1204414000949	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
1204414000950	Zn binding site [ion binding]; other site
1204414000951	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
1204414000952	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1204414000953	Excalibur calcium-binding domain; Region: Excalibur; smart00894
1204414000954	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1204414000955	Predicted esterase [General function prediction only]; Region: COG0627
1204414000956	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
1204414000957	Chain length determinant protein; Region: Wzz; cl15801
1204414000958	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1204414000959	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1204414000960	Low molecular weight phosphatase family; Region: LMWPc; cl00105
1204414000961	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1204414000962	active site
1204414000963	VPS10 domain; Region: VPS10; smart00602
1204414000964	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
1204414000965	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1204414000966	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
1204414000967	NAD(P) binding site [chemical binding]; other site
1204414000968	homodimer interface [polypeptide binding]; other site
1204414000969	substrate binding site [chemical binding]; other site
1204414000970	active site
1204414000971	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
1204414000972	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1204414000973	inhibitor-cofactor binding pocket; inhibition site
1204414000974	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1204414000975	catalytic residue [active]
1204414000976	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1204414000977	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1204414000978	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
1204414000979	putative ADP-binding pocket [chemical binding]; other site
1204414000980	colanic acid exporter; Provisional; Region: PRK10459
1204414000981	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
1204414000982	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1204414000983	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1204414000984	hinge; other site
1204414000985	active site
1204414000986	UDP-N-acetylmuramate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: MurB; COG0812
1204414000987	FAD binding domain; Region: FAD_binding_4; pfam01565
1204414000988	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1204414000989	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1204414000990	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1204414000991	active site
1204414000992	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1204414000993	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1204414000994	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
1204414000995	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1204414000996	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1204414000997	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1204414000998	O-Antigen ligase; Region: Wzy_C; pfam04932
1204414000999	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1204414001000	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1204414001001	active site
1204414001002	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
1204414001003	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
1204414001004	putative trimer interface [polypeptide binding]; other site
1204414001005	putative CoA binding site [chemical binding]; other site
1204414001006	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818
1204414001007	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1204414001008	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1204414001009	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1204414001010	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1204414001011	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1204414001012	active site
1204414001013	tetramer interface; other site
1204414001014	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1204414001015	putative deacylase active site [active]
1204414001016	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1204414001017	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1204414001018	non-specific DNA binding site [nucleotide binding]; other site
1204414001019	salt bridge; other site
1204414001020	sequence-specific DNA binding site [nucleotide binding]; other site
1204414001021	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
1204414001022	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1204414001023	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
1204414001024	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
1204414001025	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
1204414001026	putative Iron-sulfur protein interface [polypeptide binding]; other site
1204414001027	proximal heme binding site [chemical binding]; other site
1204414001028	distal heme binding site [chemical binding]; other site
1204414001029	putative dimer interface [polypeptide binding]; other site
1204414001030	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
1204414001031	L-aspartate oxidase; Provisional; Region: PRK06175
1204414001032	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1204414001033	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
1204414001034	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1204414001035	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1204414001036	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
1204414001037	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1204414001038	Predicted membrane protein [Function unknown]; Region: COG2733
1204414001039	Protein of unknown function (DUF2516); Region: DUF2516; pfam10724
1204414001040	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1204414001041	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1204414001042	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1204414001043	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414001044	putative substrate translocation pore; other site
1204414001045	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414001046	putative substrate translocation pore; other site
1204414001047	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414001048	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1204414001049	putative substrate translocation pore; other site
1204414001050	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
1204414001051	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1204414001052	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
1204414001053	putative active site [active]
1204414001054	putative substrate binding site [chemical binding]; other site
1204414001055	putative cosubstrate binding site; other site
1204414001056	catalytic site [active]
1204414001057	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1204414001058	intersubunit interface [polypeptide binding]; other site
1204414001059	active site
1204414001060	catalytic residue [active]
1204414001061	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
1204414001062	putative homodimer interface [polypeptide binding]; other site
1204414001063	putative homotetramer interface [polypeptide binding]; other site
1204414001064	putative allosteric switch controlling residues; other site
1204414001065	putative metal binding site [ion binding]; other site
1204414001066	putative homodimer-homodimer interface [polypeptide binding]; other site
1204414001067	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1204414001068	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1204414001069	metal-binding site [ion binding]
1204414001070	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1204414001071	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1204414001072	Htaa; Region: HtaA; pfam04213
1204414001073	Htaa; Region: HtaA; pfam04213
1204414001074	ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558
1204414001075	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1204414001076	intersubunit interface [polypeptide binding]; other site
1204414001077	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1204414001078	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1204414001079	dimer interface [polypeptide binding]; other site
1204414001080	putative PBP binding regions; other site
1204414001081	ABC-ATPase subunit  interface; other site
1204414001082	ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559
1204414001083	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1204414001084	Walker A/P-loop; other site
1204414001085	ATP binding site [chemical binding]; other site
1204414001086	Q-loop/lid; other site
1204414001087	ABC transporter signature motif; other site
1204414001088	Walker B; other site
1204414001089	D-loop; other site
1204414001090	H-loop/switch region; other site
1204414001091	Htaa; Region: HtaA; pfam04213
1204414001092	Htaa; Region: HtaA; pfam04213
1204414001093	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
1204414001094	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
1204414001095	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
1204414001096	FAD binding domain; Region: FAD_binding_4; pfam01565
1204414001097	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1204414001098	hypothetical protein; Provisional; Region: PRK07758
1204414001099	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
1204414001100	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605
1204414001101	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1204414001102	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1204414001103	acyl-activating enzyme (AAE) consensus motif; other site
1204414001104	AMP binding site [chemical binding]; other site
1204414001105	active site
1204414001106	CoA binding site [chemical binding]; other site
1204414001107	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
1204414001108	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
1204414001109	putative ADP-binding pocket [chemical binding]; other site
1204414001110	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1204414001111	catalytic core [active]
1204414001112	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1204414001113	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1204414001114	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1204414001115	dimer interface [polypeptide binding]; other site
1204414001116	phosphorylation site [posttranslational modification]
1204414001117	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1204414001118	ATP binding site [chemical binding]; other site
1204414001119	Mg2+ binding site [ion binding]; other site
1204414001120	G-X-G motif; other site
1204414001121	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1204414001122	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1204414001123	active site
1204414001124	phosphorylation site [posttranslational modification]
1204414001125	intermolecular recognition site; other site
1204414001126	dimerization interface [polypeptide binding]; other site
1204414001127	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1204414001128	DNA binding site [nucleotide binding]
1204414001129	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1204414001130	FtsX-like permease family; Region: FtsX; pfam02687
1204414001131	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1204414001132	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1204414001133	FtsX-like permease family; Region: FtsX; pfam02687
1204414001134	exopolyphosphatase; Region: exo_poly_only; TIGR03706
1204414001135	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1204414001136	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1204414001137	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1204414001138	DNA binding domain, excisionase family; Region: excise; TIGR01764
1204414001139	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1204414001140	HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1
1204414001141	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
1204414001142	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
1204414001143	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1204414001144	tRNA; other site
1204414001145	putative tRNA binding site [nucleotide binding]; other site
1204414001146	putative NADP binding site [chemical binding]; other site
1204414001147	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1204414001148	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1204414001149	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
1204414001150	domain interfaces; other site
1204414001151	active site
1204414001152	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1204414001153	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1204414001154	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1204414001155	dimerization interface [polypeptide binding]; other site
1204414001156	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414001157	metabolite-proton symporter; Region: 2A0106; TIGR00883
1204414001158	putative substrate translocation pore; other site
1204414001159	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1204414001160	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1204414001161	AP (apurinic/apyrimidinic) site pocket; other site
1204414001162	DNA interaction; other site
1204414001163	Metal-binding active site; metal-binding site
1204414001164	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
1204414001165	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1204414001166	active site
1204414001167	metal binding site [ion binding]; metal-binding site
1204414001168	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
1204414001169	active site
1204414001170	Fe binding site [ion binding]; other site
1204414001171	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1204414001172	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1204414001173	active site
1204414001174	trimer interface [polypeptide binding]; other site
1204414001175	dimer interface [polypeptide binding]; other site
1204414001176	quinate/shikimate dehydrogenase; Provisional; Region: PRK14027
1204414001177	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1204414001178	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1204414001179	shikimate binding site; other site
1204414001180	NAD(P) binding site [chemical binding]; other site
1204414001181	Ribosomal protein L7/L12 [Translation, ribosomal structure and biogenesis]; Region: RplL; COG0222
1204414001182	L11 interface [polypeptide binding]; other site
1204414001183	putative EF-Tu interaction site [polypeptide binding]; other site
1204414001184	putative EF-G interaction site [polypeptide binding]; other site
1204414001185	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1204414001186	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1204414001187	Walker A/P-loop; other site
1204414001188	ATP binding site [chemical binding]; other site
1204414001189	Q-loop/lid; other site
1204414001190	ABC transporter signature motif; other site
1204414001191	Walker B; other site
1204414001192	D-loop; other site
1204414001193	H-loop/switch region; other site
1204414001194	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1204414001195	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1204414001196	dimer interface [polypeptide binding]; other site
1204414001197	conserved gate region; other site
1204414001198	putative PBP binding loops; other site
1204414001199	ABC-ATPase subunit interface; other site
1204414001200	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1204414001201	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1204414001202	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1204414001203	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815
1204414001204	active site
1204414001205	homodimer interface [polypeptide binding]; other site
1204414001206	SAM binding site [chemical binding]; other site
1204414001207	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
1204414001208	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1204414001209	active site
1204414001210	Domain of unknown function (DUF3806); Region: DUF3806; pfam12713
1204414001211	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
1204414001212	dimer interface [polypeptide binding]; other site
1204414001213	active site
1204414001214	Schiff base residues; other site
1204414001215	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1204414001216	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1204414001217	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1204414001218	substrate binding site [chemical binding]; other site
1204414001219	active site
1204414001220	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
1204414001221	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1204414001222	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1204414001223	inhibitor-cofactor binding pocket; inhibition site
1204414001224	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1204414001225	catalytic residue [active]
1204414001226	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1204414001227	catalytic core [active]
1204414001228	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1204414001229	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1204414001230	catalytic residues [active]
1204414001231	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1204414001232	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1204414001233	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333
1204414001234	ResB-like family; Region: ResB; pfam05140
1204414001235	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
1204414001236	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
1204414001237	active site
1204414001238	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
1204414001239	homotrimer interaction site [polypeptide binding]; other site
1204414001240	putative active site [active]
1204414001241	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1204414001242	putative DNA binding site [nucleotide binding]; other site
1204414001243	dimerization interface [polypeptide binding]; other site
1204414001244	putative Zn2+ binding site [ion binding]; other site
1204414001245	Protein of unknown function (DUF4229); Region: DUF4229; pfam14012
1204414001246	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
1204414001247	UbiA prenyltransferase family; Region: UbiA; pfam01040
1204414001248	acetolactate synthase catalytic subunit; Validated; Region: PRK08327
1204414001249	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824
1204414001250	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1204414001251	acyl-activating enzyme (AAE) consensus motif; other site
1204414001252	AMP binding site [chemical binding]; other site
1204414001253	active site
1204414001254	CoA binding site [chemical binding]; other site
1204414001255	Predicted membrane protein [Function unknown]; Region: COG2259
1204414001256	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1204414001257	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
1204414001258	dimer interface [polypeptide binding]; other site
1204414001259	NADP binding site [chemical binding]; other site
1204414001260	catalytic residues [active]
1204414001261	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
1204414001262	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1204414001263	putative active site [active]
1204414001264	catalytic residue [active]
1204414001265	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1204414001266	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1204414001267	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447
1204414001268	putative dimerization interface [polypeptide binding]; other site
1204414001269	putative substrate binding pocket [chemical binding]; other site
1204414001270	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
1204414001271	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
1204414001272	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1204414001273	active site
1204414001274	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
1204414001275	active site 1 [active]
1204414001276	active site 2 [active]
1204414001277	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1204414001278	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1204414001279	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
1204414001280	substrate binding site [chemical binding]; other site
1204414001281	oxyanion hole (OAH) forming residues; other site
1204414001282	trimer interface [polypeptide binding]; other site
1204414001283	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
1204414001284	aromatic arch; other site
1204414001285	DCoH dimer interaction site [polypeptide binding]; other site
1204414001286	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
1204414001287	DCoH tetramer interaction site [polypeptide binding]; other site
1204414001288	substrate binding site [chemical binding]; other site
1204414001289	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129
1204414001290	catalytic triad [active]
1204414001291	active site nucleophile [active]
1204414001292	O-succinylbenzoate synthase; Provisional; Region: PRK02901
1204414001293	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
1204414001294	active site
1204414001295	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165
1204414001296	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
1204414001297	dimer interface [polypeptide binding]; other site
1204414001298	tetramer interface [polypeptide binding]; other site
1204414001299	PYR/PP interface [polypeptide binding]; other site
1204414001300	TPP binding site [chemical binding]; other site
1204414001301	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
1204414001302	TPP-binding site; other site
1204414001303	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1204414001304	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
1204414001305	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
1204414001306	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1204414001307	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1204414001308	S-adenosylmethionine binding site [chemical binding]; other site
1204414001309	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
1204414001310	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1204414001311	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1204414001312	substrate binding pocket [chemical binding]; other site
1204414001313	chain length determination region; other site
1204414001314	substrate-Mg2+ binding site; other site
1204414001315	catalytic residues [active]
1204414001316	aspartate-rich region 1; other site
1204414001317	active site lid residues [active]
1204414001318	aspartate-rich region 2; other site
1204414001319	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
1204414001320	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1204414001321	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1204414001322	putative homodimer interface [polypeptide binding]; other site
1204414001323	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1204414001324	heterodimer interface [polypeptide binding]; other site
1204414001325	homodimer interface [polypeptide binding]; other site
1204414001326	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1204414001327	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1204414001328	23S rRNA interface [nucleotide binding]; other site
1204414001329	L7/L12 interface [polypeptide binding]; other site
1204414001330	putative thiostrepton binding site; other site
1204414001331	L25 interface [polypeptide binding]; other site
1204414001332	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1204414001333	mRNA/rRNA interface [nucleotide binding]; other site
1204414001334	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1204414001335	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1204414001336	4-aminobutyrate aminotransferase; Provisional; Region: PRK06058
1204414001337	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1204414001338	inhibitor-cofactor binding pocket; inhibition site
1204414001339	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1204414001340	catalytic residue [active]
1204414001341	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1204414001342	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1204414001343	tetramerization interface [polypeptide binding]; other site
1204414001344	NAD(P) binding site [chemical binding]; other site
1204414001345	catalytic residues [active]
1204414001346	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1204414001347	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
1204414001348	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
1204414001349	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1204414001350	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1204414001351	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1204414001352	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1204414001353	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
1204414001354	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1204414001355	23S rRNA interface [nucleotide binding]; other site
1204414001356	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1204414001357	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1204414001358	core dimer interface [polypeptide binding]; other site
1204414001359	peripheral dimer interface [polypeptide binding]; other site
1204414001360	L10 interface [polypeptide binding]; other site
1204414001361	L11 interface [polypeptide binding]; other site
1204414001362	putative EF-Tu interaction site [polypeptide binding]; other site
1204414001363	putative EF-G interaction site [polypeptide binding]; other site
1204414001364	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
1204414001365	Tetraspanin family; Region: Tetraspannin; pfam00335
1204414001366	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1204414001367	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1204414001368	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1204414001369	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1204414001370	RPB1 interaction site [polypeptide binding]; other site
1204414001371	RPB10 interaction site [polypeptide binding]; other site
1204414001372	RPB11 interaction site [polypeptide binding]; other site
1204414001373	RPB3 interaction site [polypeptide binding]; other site
1204414001374	RPB12 interaction site [polypeptide binding]; other site
1204414001375	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1204414001376	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
1204414001377	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
1204414001378	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1204414001379	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1204414001380	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1204414001381	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1204414001382	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
1204414001383	G-loop; other site
1204414001384	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1204414001385	DNA binding site [nucleotide binding]
1204414001386	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1204414001387	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1204414001388	salt bridge; other site
1204414001389	non-specific DNA binding site [nucleotide binding]; other site
1204414001390	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1204414001391	sequence-specific DNA binding site [nucleotide binding]; other site
1204414001392	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
1204414001393	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1204414001394	S17 interaction site [polypeptide binding]; other site
1204414001395	S8 interaction site; other site
1204414001396	16S rRNA interaction site [nucleotide binding]; other site
1204414001397	streptomycin interaction site [chemical binding]; other site
1204414001398	23S rRNA interaction site [nucleotide binding]; other site
1204414001399	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1204414001400	30S ribosomal protein S7; Validated; Region: PRK05302
1204414001401	elongation factor G; Reviewed; Region: PRK00007
1204414001402	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1204414001403	G1 box; other site
1204414001404	putative GEF interaction site [polypeptide binding]; other site
1204414001405	GTP/Mg2+ binding site [chemical binding]; other site
1204414001406	Switch I region; other site
1204414001407	G2 box; other site
1204414001408	G3 box; other site
1204414001409	Switch II region; other site
1204414001410	G4 box; other site
1204414001411	G5 box; other site
1204414001412	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1204414001413	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1204414001414	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1204414001415	elongation factor Tu; Reviewed; Region: PRK00049
1204414001416	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1204414001417	G1 box; other site
1204414001418	GEF interaction site [polypeptide binding]; other site
1204414001419	GTP/Mg2+ binding site [chemical binding]; other site
1204414001420	Switch I region; other site
1204414001421	G2 box; other site
1204414001422	G3 box; other site
1204414001423	Switch II region; other site
1204414001424	G4 box; other site
1204414001425	G5 box; other site
1204414001426	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1204414001427	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1204414001428	Antibiotic Binding Site [chemical binding]; other site
1204414001429	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1204414001430	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1204414001431	Walker A/P-loop; other site
1204414001432	ATP binding site [chemical binding]; other site
1204414001433	Q-loop/lid; other site
1204414001434	ABC transporter signature motif; other site
1204414001435	Walker B; other site
1204414001436	D-loop; other site
1204414001437	H-loop/switch region; other site
1204414001438	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1204414001439	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1204414001440	ABC-ATPase subunit  interface; other site
1204414001441	dimer interface [polypeptide binding]; other site
1204414001442	putative PBP binding regions; other site
1204414001443	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1204414001444	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1204414001445	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1204414001446	ABC-ATPase subunit  interface; other site
1204414001447	dimer interface [polypeptide binding]; other site
1204414001448	putative PBP binding regions; other site
1204414001449	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
1204414001450	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
1204414001451	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1204414001452	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1204414001453	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1204414001454	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1204414001455	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1204414001456	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1204414001457	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1204414001458	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1204414001459	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1204414001460	putative translocon binding site; other site
1204414001461	protein-rRNA interface [nucleotide binding]; other site
1204414001462	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1204414001463	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1204414001464	G-X-X-G motif; other site
1204414001465	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1204414001466	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1204414001467	23S rRNA interface [nucleotide binding]; other site
1204414001468	5S rRNA interface [nucleotide binding]; other site
1204414001469	putative antibiotic binding site [chemical binding]; other site
1204414001470	L25 interface [polypeptide binding]; other site
1204414001471	L27 interface [polypeptide binding]; other site
1204414001472	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1204414001473	putative translocon interaction site; other site
1204414001474	23S rRNA interface [nucleotide binding]; other site
1204414001475	signal recognition particle (SRP54) interaction site; other site
1204414001476	L23 interface [polypeptide binding]; other site
1204414001477	trigger factor interaction site; other site
1204414001478	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1204414001479	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1204414001480	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1204414001481	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1204414001482	RNA binding site [nucleotide binding]; other site
1204414001483	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1204414001484	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1204414001485	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1204414001486	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
1204414001487	active site
1204414001488	catalytic triad [active]
1204414001489	oxyanion hole [active]
1204414001490	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1204414001491	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1204414001492	active site
1204414001493	catalytic tetrad [active]
1204414001494	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
1204414001495	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
1204414001496	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
1204414001497	putative molybdopterin cofactor binding site [chemical binding]; other site
1204414001498	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
1204414001499	putative molybdopterin cofactor binding site; other site
1204414001500	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1204414001501	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1204414001502	Walker A/P-loop; other site
1204414001503	ATP binding site [chemical binding]; other site
1204414001504	Q-loop/lid; other site
1204414001505	ABC transporter signature motif; other site
1204414001506	Walker B; other site
1204414001507	D-loop; other site
1204414001508	H-loop/switch region; other site
1204414001509	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1204414001510	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414001511	Walker A/P-loop; other site
1204414001512	ATP binding site [chemical binding]; other site
1204414001513	Q-loop/lid; other site
1204414001514	ABC transporter signature motif; other site
1204414001515	Walker B; other site
1204414001516	D-loop; other site
1204414001517	H-loop/switch region; other site
1204414001518	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1204414001519	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
1204414001520	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
1204414001521	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1204414001522	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1204414001523	Coenzyme A binding pocket [chemical binding]; other site
1204414001524	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1204414001525	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1204414001526	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1204414001527	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1204414001528	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1204414001529	5S rRNA interface [nucleotide binding]; other site
1204414001530	L27 interface [polypeptide binding]; other site
1204414001531	23S rRNA interface [nucleotide binding]; other site
1204414001532	L5 interface [polypeptide binding]; other site
1204414001533	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1204414001534	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1204414001535	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1204414001536	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1204414001537	23S rRNA binding site [nucleotide binding]; other site
1204414001538	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1204414001539	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1204414001540	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1204414001541	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1204414001542	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
1204414001543	NAD binding site [chemical binding]; other site
1204414001544	catalytic residues [active]
1204414001545	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1204414001546	Zn2+ binding site [ion binding]; other site
1204414001547	Mg2+ binding site [ion binding]; other site
1204414001548	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
1204414001549	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1204414001550	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1204414001551	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1204414001552	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1204414001553	catalytic loop [active]
1204414001554	iron binding site [ion binding]; other site
1204414001555	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1204414001556	classical (c) SDRs; Region: SDR_c; cd05233
1204414001557	NAD(P) binding site [chemical binding]; other site
1204414001558	active site
1204414001559	hypothetical protein; Provisional; Region: PRK08296
1204414001560	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1204414001561	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1204414001562	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1204414001563	Cytochrome P450; Region: p450; cl12078
1204414001564	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1204414001565	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1204414001566	Bacterial transcriptional regulator; Region: IclR; pfam01614
1204414001567	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1204414001568	SecY translocase; Region: SecY; pfam00344
1204414001569	adenylate kinase; Reviewed; Region: adk; PRK00279
1204414001570	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1204414001571	AMP-binding site [chemical binding]; other site
1204414001572	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1204414001573	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1204414001574	active site
1204414001575	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1204414001576	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1204414001577	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1204414001578	rRNA binding site [nucleotide binding]; other site
1204414001579	predicted 30S ribosome binding site; other site
1204414001580	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
1204414001581	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1204414001582	30S ribosomal protein S11; Validated; Region: PRK05309
1204414001583	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1204414001584	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1204414001585	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1204414001586	RNA binding surface [nucleotide binding]; other site
1204414001587	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1204414001588	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1204414001589	alphaNTD - beta interaction site [polypeptide binding]; other site
1204414001590	alphaNTD homodimer interface [polypeptide binding]; other site
1204414001591	alphaNTD - beta' interaction site [polypeptide binding]; other site
1204414001592	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1204414001593	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1204414001594	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1204414001595	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1204414001596	dimerization interface 3.5A [polypeptide binding]; other site
1204414001597	active site
1204414001598	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1204414001599	Coenzyme A binding pocket [chemical binding]; other site
1204414001600	type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919
1204414001601	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1204414001602	FAD binding domain; Region: FAD_binding_4; pfam01565
1204414001603	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
1204414001604	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
1204414001605	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1204414001606	S-adenosylmethionine binding site [chemical binding]; other site
1204414001607	TIGR02611 family protein; Region: TIGR02611
1204414001608	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
1204414001609	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
1204414001610	active site
1204414001611	catalytic residues [active]
1204414001612	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
1204414001613	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
1204414001614	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1204414001615	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
1204414001616	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1204414001617	type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931
1204414001618	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
1204414001619	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
1204414001620	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1204414001621	23S rRNA interface [nucleotide binding]; other site
1204414001622	L3 interface [polypeptide binding]; other site
1204414001623	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1204414001624	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
1204414001625	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1204414001626	active site
1204414001627	substrate binding site [chemical binding]; other site
1204414001628	metal binding site [ion binding]; metal-binding site
1204414001629	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1204414001630	alanine racemase; Reviewed; Region: alr; PRK00053
1204414001631	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1204414001632	active site
1204414001633	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1204414001634	dimer interface [polypeptide binding]; other site
1204414001635	substrate binding site [chemical binding]; other site
1204414001636	catalytic residues [active]
1204414001637	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
1204414001638	Predicted permease [General function prediction only]; Region: COG2985
1204414001639	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
1204414001640	TrkA-C domain; Region: TrkA_C; pfam02080
1204414001641	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
1204414001642	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
1204414001643	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
1204414001644	Glycoprotease family; Region: Peptidase_M22; pfam00814
1204414001645	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1204414001646	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1204414001647	Coenzyme A binding pocket [chemical binding]; other site
1204414001648	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1204414001649	UGMP family protein; Validated; Region: PRK09604
1204414001650	Uncharacterized conserved protein [Function unknown]; Region: COG0062
1204414001651	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1204414001652	putative substrate binding site [chemical binding]; other site
1204414001653	putative ATP binding site [chemical binding]; other site
1204414001654	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1204414001655	oligomerisation interface [polypeptide binding]; other site
1204414001656	mobile loop; other site
1204414001657	roof hairpin; other site
1204414001658	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1204414001659	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1204414001660	ring oligomerisation interface [polypeptide binding]; other site
1204414001661	ATP/Mg binding site [chemical binding]; other site
1204414001662	stacking interactions; other site
1204414001663	hinge regions; other site
1204414001664	Transcription factor WhiB; Region: Whib; pfam02467
1204414001665	RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648
1204414001666	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1204414001667	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1204414001668	DNA binding residues [nucleotide binding]
1204414001669	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1204414001670	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1204414001671	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1204414001672	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1204414001673	active site
1204414001674	IMP dehydrogenase family protein; Region: IMP_DH_rel_2; TIGR01304
1204414001675	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1204414001676	phosphate binding site [ion binding]; other site
1204414001677	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
1204414001678	EamA-like transporter family; Region: EamA; pfam00892
1204414001679	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1204414001680	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1204414001681	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
1204414001682	putative dimerization interface [polypeptide binding]; other site
1204414001683	GMP synthase; Reviewed; Region: guaA; PRK00074
1204414001684	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1204414001685	AMP/PPi binding site [chemical binding]; other site
1204414001686	candidate oxyanion hole; other site
1204414001687	catalytic triad [active]
1204414001688	potential glutamine specificity residues [chemical binding]; other site
1204414001689	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1204414001690	ATP Binding subdomain [chemical binding]; other site
1204414001691	Ligand Binding sites [chemical binding]; other site
1204414001692	Dimerization subdomain; other site
1204414001693	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
1204414001694	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
1204414001695	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1204414001696	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1204414001697	ATP binding site [chemical binding]; other site
1204414001698	Mg2+ binding site [ion binding]; other site
1204414001699	G-X-G motif; other site
1204414001700	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1204414001701	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1204414001702	active site
1204414001703	phosphorylation site [posttranslational modification]
1204414001704	intermolecular recognition site; other site
1204414001705	dimerization interface [polypeptide binding]; other site
1204414001706	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1204414001707	dimerization interface [polypeptide binding]; other site
1204414001708	DNA binding residues [nucleotide binding]
1204414001709	DNA Polymerase Y-family; Region: PolY_like; cd03468
1204414001710	active site
1204414001711	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
1204414001712	DNA binding site [nucleotide binding]
1204414001713	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
1204414001714	putative dimer interface [polypeptide binding]; other site
1204414001715	putative [2Fe-2S] cluster binding site [ion binding]; other site
1204414001716	prenyltransferase; Reviewed; Region: ubiA; PRK13105
1204414001717	UbiA prenyltransferase family; Region: UbiA; pfam01040
1204414001718	lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462
1204414001719	lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462
1204414001720	phytoene desaturase; Region: crtI_fam; TIGR02734
1204414001721	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1204414001722	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
1204414001723	active site lid residues [active]
1204414001724	substrate binding pocket [chemical binding]; other site
1204414001725	catalytic residues [active]
1204414001726	substrate-Mg2+ binding site; other site
1204414001727	aspartate-rich region 1; other site
1204414001728	aspartate-rich region 2; other site
1204414001729	MMPL family; Region: MMPL; pfam03176
1204414001730	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1204414001731	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1204414001732	substrate binding pocket [chemical binding]; other site
1204414001733	chain length determination region; other site
1204414001734	substrate-Mg2+ binding site; other site
1204414001735	catalytic residues [active]
1204414001736	aspartate-rich region 1; other site
1204414001737	active site lid residues [active]
1204414001738	aspartate-rich region 2; other site
1204414001739	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1204414001740	MarR family; Region: MarR_2; pfam12802
1204414001741	Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040
1204414001742	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
1204414001743	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1204414001744	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1204414001745	NAD(P) binding site [chemical binding]; other site
1204414001746	active site
1204414001747	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
1204414001748	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
1204414001749	DNA photolyase; Region: DNA_photolyase; pfam00875
1204414001750	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1204414001751	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1204414001752	active site
1204414001753	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1204414001754	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1204414001755	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1204414001756	FtsX-like permease family; Region: FtsX; pfam02687
1204414001757	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1204414001758	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1204414001759	Walker A/P-loop; other site
1204414001760	ATP binding site [chemical binding]; other site
1204414001761	Q-loop/lid; other site
1204414001762	ABC transporter signature motif; other site
1204414001763	Walker B; other site
1204414001764	D-loop; other site
1204414001765	H-loop/switch region; other site
1204414001766	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1204414001767	dimer interface [polypeptide binding]; other site
1204414001768	conserved gate region; other site
1204414001769	putative PBP binding loops; other site
1204414001770	ABC-ATPase subunit interface; other site
1204414001771	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
1204414001772	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1204414001773	Walker A/P-loop; other site
1204414001774	ATP binding site [chemical binding]; other site
1204414001775	Q-loop/lid; other site
1204414001776	ABC transporter signature motif; other site
1204414001777	Walker B; other site
1204414001778	D-loop; other site
1204414001779	H-loop/switch region; other site
1204414001780	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
1204414001781	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1204414001782	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1204414001783	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
1204414001784	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
1204414001785	active site
1204414001786	PHP Thumb interface [polypeptide binding]; other site
1204414001787	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1204414001788	generic binding surface II; other site
1204414001789	generic binding surface I; other site
1204414001790	Uncharacterized conserved protein [Function unknown]; Region: COG3402
1204414001791	Predicted membrane protein [Function unknown]; Region: COG3428
1204414001792	Bacterial PH domain; Region: DUF304; pfam03703
1204414001793	Bacterial PH domain; Region: DUF304; cl01348
1204414001794	Bacterial PH domain; Region: DUF304; pfam03703
1204414001795	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
1204414001796	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1204414001797	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1204414001798	FeoA domain; Region: FeoA; pfam04023
1204414001799	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
1204414001800	NAD-dependent deacetylase; Provisional; Region: PRK00481
1204414001801	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
1204414001802	NAD+ binding site [chemical binding]; other site
1204414001803	substrate binding site [chemical binding]; other site
1204414001804	Zn binding site [ion binding]; other site
1204414001805	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1204414001806	nucleoside/Zn binding site; other site
1204414001807	dimer interface [polypeptide binding]; other site
1204414001808	catalytic motif [active]
1204414001809	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1204414001810	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1204414001811	siderophore binding site; other site
1204414001812	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1204414001813	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
1204414001814	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1204414001815	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1204414001816	homodimer interface [polypeptide binding]; other site
1204414001817	NADP binding site [chemical binding]; other site
1204414001818	substrate binding site [chemical binding]; other site
1204414001819	Protein of unknown function (DUF3017); Region: DUF3017; pfam11222
1204414001820	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
1204414001821	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
1204414001822	Protein of unknown function (DUF3500); Region: DUF3500; pfam12006
1204414001823	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
1204414001824	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
1204414001825	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05613
1204414001826	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1204414001827	homodimer interface [polypeptide binding]; other site
1204414001828	substrate-cofactor binding pocket; other site
1204414001829	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1204414001830	catalytic residue [active]
1204414001831	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
1204414001832	Carbon starvation protein CstA; Region: CstA; pfam02554
1204414001833	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
1204414001834	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
1204414001835	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1204414001836	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1204414001837	tetramer interface [polypeptide binding]; other site
1204414001838	active site
1204414001839	Mg2+/Mn2+ binding site [ion binding]; other site
1204414001840	citrate synthase; Provisional; Region: PRK14033
1204414001841	Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111
1204414001842	dimer interface [polypeptide binding]; other site
1204414001843	active site
1204414001844	citrylCoA binding site [chemical binding]; other site
1204414001845	oxalacetate/citrate binding site [chemical binding]; other site
1204414001846	coenzyme A binding site [chemical binding]; other site
1204414001847	catalytic triad [active]
1204414001848	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
1204414001849	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1204414001850	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1204414001851	DNA-binding site [nucleotide binding]; DNA binding site
1204414001852	FCD domain; Region: FCD; pfam07729
1204414001853	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
1204414001854	isocitrate dehydrogenase, NADP-dependent, monomeric type; Region: monomer_idh; TIGR00178
1204414001855	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
1204414001856	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
1204414001857	FAD binding pocket [chemical binding]; other site
1204414001858	FAD binding motif [chemical binding]; other site
1204414001859	phosphate binding motif [ion binding]; other site
1204414001860	NAD binding pocket [chemical binding]; other site
1204414001861	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1204414001862	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1204414001863	Walker A/P-loop; other site
1204414001864	ATP binding site [chemical binding]; other site
1204414001865	Q-loop/lid; other site
1204414001866	ABC transporter signature motif; other site
1204414001867	Walker B; other site
1204414001868	D-loop; other site
1204414001869	H-loop/switch region; other site
1204414001870	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1204414001871	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1204414001872	ABC-ATPase subunit  interface; other site
1204414001873	dimer interface [polypeptide binding]; other site
1204414001874	putative PBP binding regions; other site
1204414001875	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1204414001876	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1204414001877	ABC-ATPase subunit  interface; other site
1204414001878	dimer interface [polypeptide binding]; other site
1204414001879	putative PBP binding regions; other site
1204414001880	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1204414001881	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1204414001882	siderophore binding site; other site
1204414001883	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1204414001884	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414001885	putative substrate translocation pore; other site
1204414001886	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1204414001887	putative catalytic site [active]
1204414001888	putative metal binding site [ion binding]; other site
1204414001889	putative phosphate binding site [ion binding]; other site
1204414001890	Predicted membrane protein [Function unknown]; Region: COG2860
1204414001891	UPF0126 domain; Region: UPF0126; pfam03458
1204414001892	UPF0126 domain; Region: UPF0126; pfam03458
1204414001893	Periplasmic binding protein TroA_d.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141
1204414001894	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1204414001895	putative ligand binding site [chemical binding]; other site
1204414001896	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1204414001897	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1204414001898	Walker A/P-loop; other site
1204414001899	ATP binding site [chemical binding]; other site
1204414001900	Q-loop/lid; other site
1204414001901	ABC transporter signature motif; other site
1204414001902	Walker B; other site
1204414001903	D-loop; other site
1204414001904	H-loop/switch region; other site
1204414001905	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1204414001906	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1204414001907	ABC-ATPase subunit  interface; other site
1204414001908	dimer interface [polypeptide binding]; other site
1204414001909	putative PBP binding regions; other site
1204414001910	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1204414001911	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1204414001912	active site
1204414001913	HIGH motif; other site
1204414001914	dimer interface [polypeptide binding]; other site
1204414001915	KMSKS motif; other site
1204414001916	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
1204414001917	RDD family; Region: RDD; pfam06271
1204414001918	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1204414001919	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1204414001920	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1204414001921	NlpC/P60 family; Region: NLPC_P60; pfam00877
1204414001922	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1204414001923	active site
1204414001924	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1204414001925	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1204414001926	non-specific DNA binding site [nucleotide binding]; other site
1204414001927	salt bridge; other site
1204414001928	sequence-specific DNA binding site [nucleotide binding]; other site
1204414001929	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
1204414001930	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
1204414001931	active site
1204414001932	substrate binding site [chemical binding]; other site
1204414001933	metal binding site [ion binding]; metal-binding site
1204414001934	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1204414001935	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
1204414001936	metal binding site [ion binding]; metal-binding site
1204414001937	putative dimer interface [polypeptide binding]; other site
1204414001938	flavoprotein disulfide reductase; Reviewed; Region: PRK07845
1204414001939	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1204414001940	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1204414001941	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1204414001942	pyruvate carboxylase; Reviewed; Region: PRK12999
1204414001943	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1204414001944	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1204414001945	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1204414001946	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1204414001947	active site
1204414001948	catalytic residues [active]
1204414001949	metal binding site [ion binding]; metal-binding site
1204414001950	homodimer binding site [polypeptide binding]; other site
1204414001951	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1204414001952	carboxyltransferase (CT) interaction site; other site
1204414001953	biotinylation site [posttranslational modification]; other site
1204414001954	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
1204414001955	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1204414001956	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1204414001957	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1204414001958	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1204414001959	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1204414001960	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1204414001961	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1204414001962	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
1204414001963	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1204414001964	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1204414001965	tetramer interface [polypeptide binding]; other site
1204414001966	active site
1204414001967	Mg2+/Mn2+ binding site [ion binding]; other site
1204414001968	citrate synthase; Provisional; Region: PRK14033
1204414001969	Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111
1204414001970	dimer interface [polypeptide binding]; other site
1204414001971	active site
1204414001972	citrylCoA binding site [chemical binding]; other site
1204414001973	oxalacetate/citrate binding site [chemical binding]; other site
1204414001974	coenzyme A binding site [chemical binding]; other site
1204414001975	catalytic triad [active]
1204414001976	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1204414001977	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1204414001978	non-specific DNA binding site [nucleotide binding]; other site
1204414001979	salt bridge; other site
1204414001980	sequence-specific DNA binding site [nucleotide binding]; other site
1204414001981	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
1204414001982	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1204414001983	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
1204414001984	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1204414001985	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1204414001986	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1204414001987	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1204414001988	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1204414001989	carboxyltransferase (CT) interaction site; other site
1204414001990	biotinylation site [posttranslational modification]; other site
1204414001991	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1204414001992	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1204414001993	active site residue [active]
1204414001994	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1204414001995	active site residue [active]
1204414001996	Protein of unknown function (DUF3151); Region: DUF3151; pfam11349
1204414001997	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1204414001998	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
1204414001999	Maf-like protein; Region: Maf; pfam02545
1204414002000	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1204414002001	active site
1204414002002	dimer interface [polypeptide binding]; other site
1204414002003	Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822
1204414002004	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1204414002005	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1204414002006	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1204414002007	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1204414002008	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1204414002009	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1204414002010	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
1204414002011	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
1204414002012	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1204414002013	ATP-grasp domain; Region: ATP-grasp; pfam02222
1204414002014	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
1204414002015	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
1204414002016	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1204414002017	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1204414002018	putative active site [active]
1204414002019	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
1204414002020	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1204414002021	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1204414002022	active site
1204414002023	non-prolyl cis peptide bond; other site
1204414002024	Winged helix-turn helix; Region: HTH_29; pfam13551
1204414002025	Helix-turn-helix domain; Region: HTH_28; pfam13518
1204414002026	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1204414002027	Integrase core domain; Region: rve; pfam00665
1204414002028	Integrase core domain; Region: rve_3; pfam13683
1204414002029	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642
1204414002030	putative beta-ketoacyl acyl carrier protein [ACP]reductase (BKR), subgroup 2, classical (c) SDR; Region: BKR_2_SDR_c; cd05349
1204414002031	putative NAD(P) binding site [chemical binding]; other site
1204414002032	active site
1204414002033	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1204414002034	RibD C-terminal domain; Region: RibD_C; cl17279
1204414002035	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353
1204414002036	putative dimer interface [polypeptide binding]; other site
1204414002037	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1204414002038	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1204414002039	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1204414002040	dimer interface [polypeptide binding]; other site
1204414002041	conserved gate region; other site
1204414002042	putative PBP binding loops; other site
1204414002043	ABC-ATPase subunit interface; other site
1204414002044	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1204414002045	dimer interface [polypeptide binding]; other site
1204414002046	conserved gate region; other site
1204414002047	putative PBP binding loops; other site
1204414002048	ABC-ATPase subunit interface; other site
1204414002049	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901
1204414002050	putative hydrophobic ligand binding site [chemical binding]; other site
1204414002051	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1204414002052	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1204414002053	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1204414002054	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1204414002055	Walker A/P-loop; other site
1204414002056	ATP binding site [chemical binding]; other site
1204414002057	Q-loop/lid; other site
1204414002058	ABC transporter signature motif; other site
1204414002059	Walker B; other site
1204414002060	D-loop; other site
1204414002061	H-loop/switch region; other site
1204414002062	TOBE domain; Region: TOBE_2; pfam08402
1204414002063	Predicted membrane protein (DUF2127); Region: DUF2127; cl01785
1204414002064	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
1204414002065	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1204414002066	ATP binding site [chemical binding]; other site
1204414002067	putative Mg++ binding site [ion binding]; other site
1204414002068	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1204414002069	ATP-binding site [chemical binding]; other site
1204414002070	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
1204414002071	TIGR03089 family protein; Region: TIGR03089
1204414002072	Protein of unknown function DUF262; Region: DUF262; pfam03235
1204414002073	Uncharacterized conserved protein [Function unknown]; Region: COG1479
1204414002074	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
1204414002075	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1204414002076	Family description; Region: UvrD_C_2; pfam13538
1204414002077	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
1204414002078	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1204414002079	ATP binding site [chemical binding]; other site
1204414002080	putative Mg++ binding site [ion binding]; other site
1204414002081	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1204414002082	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1204414002083	ATP-binding site [chemical binding]; other site
1204414002084	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
1204414002085	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
1204414002086	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
1204414002087	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1204414002088	ATP binding site [chemical binding]; other site
1204414002089	putative Mg++ binding site [ion binding]; other site
1204414002090	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1204414002091	nucleotide binding region [chemical binding]; other site
1204414002092	ATP-binding site [chemical binding]; other site
1204414002093	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1204414002094	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
1204414002095	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1204414002096	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
1204414002097	Probable Catalytic site; other site
1204414002098	metal-binding site
1204414002099	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1204414002100	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
1204414002101	active site
1204414002102	Substrate binding site; other site
1204414002103	Mg++ binding site; other site
1204414002104	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1204414002105	putative trimer interface [polypeptide binding]; other site
1204414002106	putative CoA binding site [chemical binding]; other site
1204414002107	Transcription factor WhiB; Region: Whib; pfam02467
1204414002108	Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
1204414002109	Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
1204414002110	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
1204414002111	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
1204414002112	active site
1204414002113	substrate binding site [chemical binding]; other site
1204414002114	metal binding site [ion binding]; metal-binding site
1204414002115	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
1204414002116	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
1204414002117	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
1204414002118	Domain of unknown function (DUF4259); Region: DUF4259; pfam14078
1204414002119	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
1204414002120	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
1204414002121	homotetramer interface [polypeptide binding]; other site
1204414002122	ligand binding site [chemical binding]; other site
1204414002123	catalytic site [active]
1204414002124	NAD binding site [chemical binding]; other site
1204414002125	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
1204414002126	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1204414002127	TMP-binding site; other site
1204414002128	ATP-binding site [chemical binding]; other site
1204414002129	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1204414002130	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1204414002131	active site
1204414002132	phosphorylation site [posttranslational modification]
1204414002133	intermolecular recognition site; other site
1204414002134	dimerization interface [polypeptide binding]; other site
1204414002135	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1204414002136	DNA binding site [nucleotide binding]
1204414002137	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1204414002138	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1204414002139	dimerization interface [polypeptide binding]; other site
1204414002140	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1204414002141	dimer interface [polypeptide binding]; other site
1204414002142	phosphorylation site [posttranslational modification]
1204414002143	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1204414002144	ATP binding site [chemical binding]; other site
1204414002145	Mg2+ binding site [ion binding]; other site
1204414002146	G-X-G motif; other site
1204414002147	lipoprotein LpqB; Provisional; Region: PRK13616
1204414002148	Sporulation and spore germination; Region: Germane; pfam10646
1204414002149	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1204414002150	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1204414002151	active site
1204414002152	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1204414002153	30S subunit binding site; other site
1204414002154	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1204414002155	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1204414002156	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1204414002157	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
1204414002158	nucleotide binding region [chemical binding]; other site
1204414002159	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1204414002160	REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252
1204414002161	Predicted GTPases [General function prediction only]; Region: COG1162
1204414002162	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1204414002163	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1204414002164	GTP/Mg2+ binding site [chemical binding]; other site
1204414002165	G4 box; other site
1204414002166	G1 box; other site
1204414002167	Switch I region; other site
1204414002168	G2 box; other site
1204414002169	G3 box; other site
1204414002170	Switch II region; other site
1204414002171	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1204414002172	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1204414002173	hinge; other site
1204414002174	active site
1204414002175	Uncharacterized conserved protein [Function unknown]; Region: COG2135
1204414002176	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1204414002177	active site
1204414002178	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
1204414002179	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1204414002180	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1204414002181	DNA binding residues [nucleotide binding]
1204414002182	Transcription factor WhiB; Region: Whib; pfam02467
1204414002183	PQQ-like domain; Region: PQQ_2; pfam13360
1204414002184	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1204414002185	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1204414002186	ATP binding site [chemical binding]; other site
1204414002187	Mg++ binding site [ion binding]; other site
1204414002188	motif III; other site
1204414002189	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1204414002190	nucleotide binding region [chemical binding]; other site
1204414002191	ATP-binding site [chemical binding]; other site
1204414002192	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
1204414002193	Protein of unknown function (DUF3152); Region: DUF3152; pfam11350
1204414002194	TIGR02569 family protein; Region: TIGR02569_actnb
1204414002195	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1204414002196	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
1204414002197	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1204414002198	Family description; Region: UvrD_C_2; pfam13538
1204414002199	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
1204414002200	Ion channel; Region: Ion_trans_2; pfam07885
1204414002201	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
1204414002202	TrkA-N domain; Region: TrkA_N; pfam02254
1204414002203	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
1204414002204	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
1204414002205	putative NADH binding site [chemical binding]; other site
1204414002206	putative active site [active]
1204414002207	nudix motif; other site
1204414002208	putative metal binding site [ion binding]; other site
1204414002209	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1204414002210	Part of AAA domain; Region: AAA_19; pfam13245
1204414002211	Family description; Region: UvrD_C_2; pfam13538
1204414002212	HRDC domain; Region: HRDC; pfam00570
1204414002213	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
1204414002214	Uncharacterized conserved protein [Function unknown]; Region: COG5282
1204414002215	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
1204414002216	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
1204414002217	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1204414002218	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1204414002219	hypothetical protein; Validated; Region: PRK00068
1204414002220	Uncharacterized conserved protein [Function unknown]; Region: COG1615
1204414002221	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1204414002222	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1204414002223	DNA-binding site [nucleotide binding]; DNA binding site
1204414002224	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1204414002225	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1204414002226	homodimer interface [polypeptide binding]; other site
1204414002227	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
1204414002228	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
1204414002229	active site
1204414002230	multimer interface [polypeptide binding]; other site
1204414002231	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
1204414002232	predicted active site [active]
1204414002233	catalytic triad [active]
1204414002234	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
1204414002235	substrate binding sites [chemical binding]; other site
1204414002236	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
1204414002237	LGFP repeat; Region: LGFP; pfam08310
1204414002238	LGFP repeat; Region: LGFP; pfam08310
1204414002239	LGFP repeat; Region: LGFP; pfam08310
1204414002240	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1204414002241	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
1204414002242	active site
1204414002243	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
1204414002244	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1204414002245	active site
1204414002246	peptide chain release factor 2; Validated; Region: prfB; PRK00578
1204414002247	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1204414002248	RF-1 domain; Region: RF-1; pfam00472
1204414002249	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1204414002250	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414002251	Walker A/P-loop; other site
1204414002252	ATP binding site [chemical binding]; other site
1204414002253	Q-loop/lid; other site
1204414002254	ABC transporter signature motif; other site
1204414002255	Walker B; other site
1204414002256	D-loop; other site
1204414002257	H-loop/switch region; other site
1204414002258	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
1204414002259	FtsX-like permease family; Region: FtsX; pfam02687
1204414002260	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1204414002261	SmpB-tmRNA interface; other site
1204414002262	Uncharacterized conserved protein [Function unknown]; Region: COG3189
1204414002263	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1204414002264	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
1204414002265	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
1204414002266	FAD binding pocket [chemical binding]; other site
1204414002267	FAD binding motif [chemical binding]; other site
1204414002268	phosphate binding motif [ion binding]; other site
1204414002269	NAD binding pocket [chemical binding]; other site
1204414002270	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1204414002271	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1204414002272	siderophore binding site; other site
1204414002273	Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922
1204414002274	putative active site [active]
1204414002275	redox center [active]
1204414002276	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
1204414002277	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1204414002278	intersubunit interface [polypeptide binding]; other site
1204414002279	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1204414002280	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1204414002281	ABC-ATPase subunit  interface; other site
1204414002282	dimer interface [polypeptide binding]; other site
1204414002283	putative PBP binding regions; other site
1204414002284	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1204414002285	ABC-ATPase subunit  interface; other site
1204414002286	dimer interface [polypeptide binding]; other site
1204414002287	putative PBP binding regions; other site
1204414002288	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
1204414002289	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1204414002290	Walker A/P-loop; other site
1204414002291	ATP binding site [chemical binding]; other site
1204414002292	Q-loop/lid; other site
1204414002293	ABC transporter signature motif; other site
1204414002294	Walker B; other site
1204414002295	D-loop; other site
1204414002296	H-loop/switch region; other site
1204414002297	aminotransferase; Validated; Region: PRK07777
1204414002298	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1204414002299	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1204414002300	homodimer interface [polypeptide binding]; other site
1204414002301	catalytic residue [active]
1204414002302	Protein of unknown function (DUF3239); Region: DUF3239; pfam11580
1204414002303	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
1204414002304	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1204414002305	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1204414002306	ATP binding site [chemical binding]; other site
1204414002307	putative Mg++ binding site [ion binding]; other site
1204414002308	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1204414002309	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
1204414002310	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
1204414002311	Protein of unknown function (DUF3235); Region: DUF3235; pfam11574
1204414002312	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1204414002313	DNA-binding site [nucleotide binding]; DNA binding site
1204414002314	RNA-binding motif; other site
1204414002315	Protein of unknown function (DUF2771); Region: DUF2771; pfam10969
1204414002316	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
1204414002317	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1204414002318	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
1204414002319	substrate-cofactor binding pocket; other site
1204414002320	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1204414002321	catalytic residue [active]
1204414002322	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1204414002323	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1204414002324	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
1204414002325	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1204414002326	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
1204414002327	phosphoserine aminotransferase, putative; Region: serC_3; TIGR01366
1204414002328	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1204414002329	catalytic residue [active]
1204414002330	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
1204414002331	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1204414002332	dimer interface [polypeptide binding]; other site
1204414002333	active site
1204414002334	citrylCoA binding site [chemical binding]; other site
1204414002335	NADH binding [chemical binding]; other site
1204414002336	cationic pore residues; other site
1204414002337	oxalacetate/citrate binding site [chemical binding]; other site
1204414002338	coenzyme A binding site [chemical binding]; other site
1204414002339	catalytic triad [active]
1204414002340	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
1204414002341	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1204414002342	Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777
1204414002343	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1204414002344	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825
1204414002345	Predicted membrane protein [Function unknown]; Region: COG3162
1204414002346	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1204414002347	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
1204414002348	Na binding site [ion binding]; other site
1204414002349	Domain of unknown function (DUF1906); Region: DUF1906; pfam08924
1204414002350	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1204414002351	Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981
1204414002352	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1204414002353	phosphate binding site [ion binding]; other site
1204414002354	Domain of unknown function (DUF1729); Region: DUF1729; pfam08354
1204414002355	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1204414002356	active site 2 [active]
1204414002357	active site 1 [active]
1204414002358	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1204414002359	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1204414002360	3-oxoacyl-[acyl-carrier protein]; Region: COG4982
1204414002361	ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950
1204414002362	putative NAD(P) binding site [chemical binding]; other site
1204414002363	active site
1204414002364	"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828
1204414002365	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
1204414002366	active site
1204414002367	Septum formation; Region: Septum_form; pfam13845
1204414002368	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
1204414002369	hypothetical protein; Validated; Region: PRK07581
1204414002370	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1204414002371	catalytic residues [active]
1204414002372	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1204414002373	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1204414002374	folate binding site [chemical binding]; other site
1204414002375	NADP+ binding site [chemical binding]; other site
1204414002376	thymidylate synthase; Reviewed; Region: thyA; PRK01827
1204414002377	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1204414002378	dimerization interface [polypeptide binding]; other site
1204414002379	active site
1204414002380	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
1204414002381	active site
1204414002382	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1204414002383	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
1204414002384	ATP binding site [chemical binding]; other site
1204414002385	putative Mg++ binding site [ion binding]; other site
1204414002386	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1204414002387	nucleotide binding region [chemical binding]; other site
1204414002388	ATP-binding site [chemical binding]; other site
1204414002389	DEAD/H associated; Region: DEAD_assoc; pfam08494
1204414002390	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
1204414002391	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
1204414002392	putative DNA binding site [nucleotide binding]; other site
1204414002393	catalytic residue [active]
1204414002394	putative H2TH interface [polypeptide binding]; other site
1204414002395	putative catalytic residues [active]
1204414002396	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1204414002397	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1204414002398	Predicted membrane protein [Function unknown]; Region: COG3304
1204414002399	Domain of unknown function (DUF307); Region: DUF307; pfam03733
1204414002400	Domain of unknown function (DUF307); Region: DUF307; pfam03733
1204414002401	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1204414002402	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1204414002403	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
1204414002404	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414002405	putative substrate translocation pore; other site
1204414002406	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
1204414002407	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1204414002408	active site
1204414002409	dimer interface [polypeptide binding]; other site
1204414002410	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1204414002411	dimer interface [polypeptide binding]; other site
1204414002412	active site
1204414002413	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1204414002414	active site
1204414002415	hypothetical protein; Provisional; Region: PRK07857
1204414002416	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1204414002417	Part of AAA domain; Region: AAA_19; pfam13245
1204414002418	Family description; Region: UvrD_C_2; pfam13538
1204414002419	FtsX-like permease family; Region: FtsX; pfam02687
1204414002420	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1204414002421	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1204414002422	Walker A/P-loop; other site
1204414002423	ATP binding site [chemical binding]; other site
1204414002424	Q-loop/lid; other site
1204414002425	ABC transporter signature motif; other site
1204414002426	Walker B; other site
1204414002427	D-loop; other site
1204414002428	H-loop/switch region; other site
1204414002429	Predicted transcriptional regulators [Transcription]; Region: COG1695
1204414002430	Transcriptional regulator PadR-like family; Region: PadR; cl17335
1204414002431	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1204414002432	Peptidase family M23; Region: Peptidase_M23; pfam01551
1204414002433	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1204414002434	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1204414002435	active site
1204414002436	substrate binding site [chemical binding]; other site
1204414002437	cosubstrate binding site; other site
1204414002438	catalytic site [active]
1204414002439	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1204414002440	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1204414002441	purine monophosphate binding site [chemical binding]; other site
1204414002442	dimer interface [polypeptide binding]; other site
1204414002443	putative catalytic residues [active]
1204414002444	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1204414002445	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1204414002446	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
1204414002447	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1204414002448	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1204414002449	30S ribosomal protein S18; Provisional; Region: PRK13401
1204414002450	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1204414002451	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1204414002452	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1204414002453	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1204414002454	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1204414002455	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1204414002456	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1204414002457	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1204414002458	dimerization interface [polypeptide binding]; other site
1204414002459	putative DNA binding site [nucleotide binding]; other site
1204414002460	putative Zn2+ binding site [ion binding]; other site
1204414002461	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
1204414002462	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
1204414002463	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1204414002464	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1204414002465	active site
1204414002466	phosphorylation site [posttranslational modification]
1204414002467	intermolecular recognition site; other site
1204414002468	dimerization interface [polypeptide binding]; other site
1204414002469	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1204414002470	DNA binding site [nucleotide binding]
1204414002471	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
1204414002472	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1204414002473	dimerization interface [polypeptide binding]; other site
1204414002474	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1204414002475	dimer interface [polypeptide binding]; other site
1204414002476	phosphorylation site [posttranslational modification]
1204414002477	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1204414002478	ATP binding site [chemical binding]; other site
1204414002479	Mg2+ binding site [ion binding]; other site
1204414002480	G-X-G motif; other site
1204414002481	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1204414002482	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1204414002483	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1204414002484	protein binding site [polypeptide binding]; other site
1204414002485	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1204414002486	MPT binding site; other site
1204414002487	trimer interface [polypeptide binding]; other site
1204414002488	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1204414002489	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
1204414002490	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
1204414002491	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1204414002492	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
1204414002493	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1204414002494	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1204414002495	active site
1204414002496	tetramer interface; other site
1204414002497	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1204414002498	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1204414002499	dimer interface [polypeptide binding]; other site
1204414002500	putative functional site; other site
1204414002501	putative MPT binding site; other site
1204414002502	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1204414002503	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1204414002504	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
1204414002505	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414002506	putative substrate translocation pore; other site
1204414002507	Predicted membrane protein [Function unknown]; Region: COG2259
1204414002508	Predicted integral membrane protein [Function unknown]; Region: COG5660
1204414002509	Putative zinc-finger; Region: zf-HC2; pfam13490
1204414002510	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354
1204414002511	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1204414002512	active site
1204414002513	catalytic site [active]
1204414002514	Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928
1204414002515	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
1204414002516	Predicted methyltransferases [General function prediction only]; Region: COG0313
1204414002517	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1204414002518	putative SAM binding site [chemical binding]; other site
1204414002519	putative homodimer interface [polypeptide binding]; other site
1204414002520	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
1204414002521	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
1204414002522	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1204414002523	active site
1204414002524	HIGH motif; other site
1204414002525	KMSKS motif; other site
1204414002526	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1204414002527	tRNA binding surface [nucleotide binding]; other site
1204414002528	anticodon binding site; other site
1204414002529	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
1204414002530	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1204414002531	ATP binding site [chemical binding]; other site
1204414002532	putative Mg++ binding site [ion binding]; other site
1204414002533	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1204414002534	nucleotide binding region [chemical binding]; other site
1204414002535	ATP-binding site [chemical binding]; other site
1204414002536	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
1204414002537	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1204414002538	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1204414002539	HTH-like domain; Region: HTH_21; pfam13276
1204414002540	Integrase core domain; Region: rve; pfam00665
1204414002541	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1204414002542	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1204414002543	D-lactate dehydrogenase; Provisional; Region: PRK11183
1204414002544	FAD binding domain; Region: FAD_binding_4; pfam01565
1204414002545	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
1204414002546	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
1204414002547	DNA methylase; Region: N6_N4_Mtase; pfam01555
1204414002548	HTH-like domain; Region: HTH_21; pfam13276
1204414002549	Integrase core domain; Region: rve; pfam00665
1204414002550	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1204414002551	dimerization interface [polypeptide binding]; other site
1204414002552	putative DNA binding site [nucleotide binding]; other site
1204414002553	putative Zn2+ binding site [ion binding]; other site
1204414002554	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
1204414002555	Cadmium resistance transporter; Region: Cad; pfam03596
1204414002556	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1204414002557	active site
1204414002558	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
1204414002559	Domain of unknown function (DUF348); Region: DUF348; pfam03990
1204414002560	Domain of unknown function (DUF348); Region: DUF348; pfam03990
1204414002561	G5 domain; Region: G5; pfam07501
1204414002562	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
1204414002563	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1204414002564	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1204414002565	S-adenosylmethionine binding site [chemical binding]; other site
1204414002566	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
1204414002567	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1204414002568	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1204414002569	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1204414002570	ABC transporter; Region: ABC_tran_2; pfam12848
1204414002571	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1204414002572	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
1204414002573	dimer interface [polypeptide binding]; other site
1204414002574	pyridoxal binding site [chemical binding]; other site
1204414002575	ATP binding site [chemical binding]; other site
1204414002576	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1204414002577	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1204414002578	catalytic residues [active]
1204414002579	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1204414002580	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1204414002581	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
1204414002582	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1204414002583	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1204414002584	active site
1204414002585	motif I; other site
1204414002586	motif II; other site
1204414002587	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1204414002588	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
1204414002589	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1204414002590	substrate binding site [chemical binding]; other site
1204414002591	oxyanion hole (OAH) forming residues; other site
1204414002592	trimer interface [polypeptide binding]; other site
1204414002593	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
1204414002594	Predicted membrane protein [General function prediction only]; Region: COG4194
1204414002595	Predicted esterase [General function prediction only]; Region: COG0627
1204414002596	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1204414002597	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1204414002598	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
1204414002599	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4899
1204414002600	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1204414002601	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1204414002602	active site
1204414002603	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
1204414002604	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1204414002605	G1 box; other site
1204414002606	putative GEF interaction site [polypeptide binding]; other site
1204414002607	GTP/Mg2+ binding site [chemical binding]; other site
1204414002608	Switch I region; other site
1204414002609	G2 box; other site
1204414002610	G3 box; other site
1204414002611	Switch II region; other site
1204414002612	G4 box; other site
1204414002613	G5 box; other site
1204414002614	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
1204414002615	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1204414002616	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
1204414002617	putative ligand binding site [chemical binding]; other site
1204414002618	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1204414002619	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1204414002620	TM-ABC transporter signature motif; other site
1204414002621	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1204414002622	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1204414002623	TM-ABC transporter signature motif; other site
1204414002624	Uncharacterized ABC-type transport system, ATPase component [General function prediction only]; Region: COG4674
1204414002625	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1204414002626	Walker A/P-loop; other site
1204414002627	ATP binding site [chemical binding]; other site
1204414002628	Q-loop/lid; other site
1204414002629	ABC transporter signature motif; other site
1204414002630	Walker B; other site
1204414002631	D-loop; other site
1204414002632	H-loop/switch region; other site
1204414002633	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
1204414002634	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1204414002635	Walker A/P-loop; other site
1204414002636	ATP binding site [chemical binding]; other site
1204414002637	Q-loop/lid; other site
1204414002638	ABC transporter signature motif; other site
1204414002639	Walker B; other site
1204414002640	D-loop; other site
1204414002641	H-loop/switch region; other site
1204414002642	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1204414002643	putative active site [active]
1204414002644	catalytic residue [active]
1204414002645	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
1204414002646	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1204414002647	FMN binding site [chemical binding]; other site
1204414002648	substrate binding site [chemical binding]; other site
1204414002649	putative catalytic residue [active]
1204414002650	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
1204414002651	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1204414002652	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1204414002653	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1204414002654	putative active site [active]
1204414002655	catalytic residue [active]
1204414002656	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
1204414002657	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1204414002658	5S rRNA interface [nucleotide binding]; other site
1204414002659	CTC domain interface [polypeptide binding]; other site
1204414002660	L16 interface [polypeptide binding]; other site
1204414002661	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
1204414002662	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1204414002663	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
1204414002664	A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
1204414002665	active site
1204414002666	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1204414002667	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
1204414002668	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1204414002669	active site
1204414002670	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
1204414002671	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1204414002672	Substrate binding site; other site
1204414002673	Mg++ binding site; other site
1204414002674	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1204414002675	active site
1204414002676	substrate binding site [chemical binding]; other site
1204414002677	CoA binding site [chemical binding]; other site
1204414002678	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1204414002679	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
1204414002680	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1204414002681	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1204414002682	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1204414002683	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1204414002684	Walker A/P-loop; other site
1204414002685	ATP binding site [chemical binding]; other site
1204414002686	Q-loop/lid; other site
1204414002687	ABC transporter signature motif; other site
1204414002688	Walker B; other site
1204414002689	D-loop; other site
1204414002690	H-loop/switch region; other site
1204414002691	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1204414002692	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1204414002693	Histidine kinase; Region: HisKA_3; pfam07730
1204414002694	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1204414002695	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1204414002696	active site
1204414002697	phosphorylation site [posttranslational modification]
1204414002698	intermolecular recognition site; other site
1204414002699	dimerization interface [polypeptide binding]; other site
1204414002700	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1204414002701	DNA binding residues [nucleotide binding]
1204414002702	dimerization interface [polypeptide binding]; other site
1204414002703	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
1204414002704	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1204414002705	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1204414002706	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414002707	ABC transporter signature motif; other site
1204414002708	Walker B; other site
1204414002709	D-loop; other site
1204414002710	H-loop/switch region; other site
1204414002711	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1204414002712	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1204414002713	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414002714	Walker A/P-loop; other site
1204414002715	ATP binding site [chemical binding]; other site
1204414002716	Q-loop/lid; other site
1204414002717	ABC transporter signature motif; other site
1204414002718	Walker B; other site
1204414002719	D-loop; other site
1204414002720	H-loop/switch region; other site
1204414002721	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1204414002722	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1204414002723	Excalibur calcium-binding domain; Region: Excalibur; pfam05901
1204414002724	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1204414002725	Integrase core domain; Region: rve; pfam00665
1204414002726	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1204414002727	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1204414002728	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1204414002729	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1204414002730	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1204414002731	ATP binding site [chemical binding]; other site
1204414002732	putative Mg++ binding site [ion binding]; other site
1204414002733	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1204414002734	nucleotide binding region [chemical binding]; other site
1204414002735	ATP-binding site [chemical binding]; other site
1204414002736	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1204414002737	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1204414002738	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1204414002739	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1204414002740	Walker A/P-loop; other site
1204414002741	ATP binding site [chemical binding]; other site
1204414002742	Q-loop/lid; other site
1204414002743	ABC transporter signature motif; other site
1204414002744	Walker B; other site
1204414002745	D-loop; other site
1204414002746	H-loop/switch region; other site
1204414002747	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1204414002748	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1204414002749	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414002750	Walker A/P-loop; other site
1204414002751	ATP binding site [chemical binding]; other site
1204414002752	Q-loop/lid; other site
1204414002753	ABC transporter signature motif; other site
1204414002754	Walker B; other site
1204414002755	D-loop; other site
1204414002756	H-loop/switch region; other site
1204414002757	Uncharacterized conserved protein [Function unknown]; Region: COG2898
1204414002758	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1204414002759	Predicted esterase [General function prediction only]; Region: COG0627
1204414002760	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
1204414002761	MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013
1204414002762	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1204414002763	homodimer interface [polypeptide binding]; other site
1204414002764	metal binding site [ion binding]; metal-binding site
1204414002765	Alpha helical Porin B; Region: PorB; pfam11565
1204414002766	Alpha helical Porin B; Region: PorB; pfam11565
1204414002767	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
1204414002768	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1204414002769	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1204414002770	enolase; Provisional; Region: eno; PRK00077
1204414002771	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1204414002772	dimer interface [polypeptide binding]; other site
1204414002773	metal binding site [ion binding]; metal-binding site
1204414002774	substrate binding pocket [chemical binding]; other site
1204414002775	Septum formation initiator; Region: DivIC; pfam04977
1204414002776	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1204414002777	Uncharacterized conserved protein [Function unknown]; Region: COG1507
1204414002778	exopolyphosphatase; Region: exo_poly_only; TIGR03706
1204414002779	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1204414002780	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
1204414002781	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1204414002782	tetramer interface [polypeptide binding]; other site
1204414002783	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1204414002784	catalytic residue [active]
1204414002785	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
1204414002786	RibD C-terminal domain; Region: RibD_C; cl17279
1204414002787	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
1204414002788	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1204414002789	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1204414002790	Predicted membrane protein [Function unknown]; Region: COG4760
1204414002791	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1204414002792	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1204414002793	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1204414002794	Domain of unknown function (DUF4307); Region: DUF4307; pfam14155
1204414002795	mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446
1204414002796	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
1204414002797	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1204414002798	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14828
1204414002799	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
1204414002800	catalytic residue [active]
1204414002801	putative FPP diphosphate  binding site; other site
1204414002802	putative FPP binding hydrophobic cleft; other site
1204414002803	dimer interface [polypeptide binding]; other site
1204414002804	putative IPP diphosphate binding site; other site
1204414002805	Flavodoxin domain; Region: Flavodoxin_5; pfam12724
1204414002806	pantothenate kinase; Provisional; Region: PRK05439
1204414002807	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
1204414002808	ATP-binding site [chemical binding]; other site
1204414002809	CoA-binding site [chemical binding]; other site
1204414002810	Mg2+-binding site [ion binding]; other site
1204414002811	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1204414002812	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1204414002813	dimer interface [polypeptide binding]; other site
1204414002814	active site
1204414002815	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1204414002816	folate binding site [chemical binding]; other site
1204414002817	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1204414002818	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1204414002819	glutamine binding [chemical binding]; other site
1204414002820	catalytic triad [active]
1204414002821	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1204414002822	aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824
1204414002823	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1204414002824	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1204414002825	substrate-cofactor binding pocket; other site
1204414002826	homodimer interface [polypeptide binding]; other site
1204414002827	Aminotransferase class IV; Region: Aminotran_4; pfam01063
1204414002828	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1204414002829	catalytic residue [active]
1204414002830	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1204414002831	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1204414002832	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1204414002833	Coenzyme A binding pocket [chemical binding]; other site
1204414002834	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
1204414002835	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
1204414002836	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
1204414002837	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
1204414002838	putative active site [active]
1204414002839	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
1204414002840	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1204414002841	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1204414002842	DNA-binding site [nucleotide binding]; DNA binding site
1204414002843	FCD domain; Region: FCD; pfam07729
1204414002844	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1204414002845	Class II fumarases; Region: Fumarase_classII; cd01362
1204414002846	active site
1204414002847	tetramer interface [polypeptide binding]; other site
1204414002848	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1204414002849	Predicted flavoprotein [General function prediction only]; Region: COG0431
1204414002850	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1204414002851	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1204414002852	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1204414002853	active site
1204414002854	non-prolyl cis peptide bond; other site
1204414002855	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1204414002856	active site
1204414002857	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
1204414002858	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
1204414002859	Flavin binding site [chemical binding]; other site
1204414002860	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
1204414002861	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1204414002862	active site
1204414002863	dimer interface [polypeptide binding]; other site
1204414002864	non-prolyl cis peptide bond; other site
1204414002865	insertion regions; other site
1204414002866	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
1204414002867	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
1204414002868	putative active site [active]
1204414002869	Protein of unknown function (DUF4245); Region: DUF4245; pfam14030
1204414002870	VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456
1204414002871	metal ion-dependent adhesion site (MIDAS); other site
1204414002872	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
1204414002873	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1204414002874	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
1204414002875	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1204414002876	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1204414002877	generic binding surface II; other site
1204414002878	generic binding surface I; other site
1204414002879	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
1204414002880	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
1204414002881	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1204414002882	Membrane protein of unknown function; Region: DUF360; pfam04020
1204414002883	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1204414002884	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1204414002885	uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334
1204414002886	Na2 binding site [ion binding]; other site
1204414002887	putative substrate binding site 1 [chemical binding]; other site
1204414002888	Na binding site 1 [ion binding]; other site
1204414002889	putative substrate binding site 2 [chemical binding]; other site
1204414002890	Putative esterase; Region: Esterase; pfam00756
1204414002891	GTP-binding protein YchF; Reviewed; Region: PRK09601
1204414002892	YchF GTPase; Region: YchF; cd01900
1204414002893	G1 box; other site
1204414002894	GTP/Mg2+ binding site [chemical binding]; other site
1204414002895	Switch I region; other site
1204414002896	G2 box; other site
1204414002897	Switch II region; other site
1204414002898	G3 box; other site
1204414002899	G4 box; other site
1204414002900	G5 box; other site
1204414002901	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1204414002902	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
1204414002903	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1204414002904	non-specific DNA binding site [nucleotide binding]; other site
1204414002905	salt bridge; other site
1204414002906	sequence-specific DNA binding site [nucleotide binding]; other site
1204414002907	Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Region: ArgF; COG0078
1204414002908	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1204414002909	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1204414002910	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1204414002911	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1204414002912	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1204414002913	active site
1204414002914	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1204414002915	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1204414002916	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1204414002917	MASE1; Region: MASE1; pfam05231
1204414002918	PAS domain S-box; Region: sensory_box; TIGR00229
1204414002919	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1204414002920	putative active site [active]
1204414002921	heme pocket [chemical binding]; other site
1204414002922	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1204414002923	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1204414002924	metal binding site [ion binding]; metal-binding site
1204414002925	active site
1204414002926	I-site; other site
1204414002927	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1204414002928	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1204414002929	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1204414002930	DXD motif; other site
1204414002931	NNMT/PNMT/TEMT family; Region: NNMT_PNMT_TEMT; pfam01234
1204414002932	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1204414002933	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1204414002934	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1204414002935	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1204414002936	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1204414002937	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
1204414002938	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1204414002939	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1204414002940	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1204414002941	active site
1204414002942	catalytic tetrad [active]
1204414002943	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1204414002944	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
1204414002945	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1204414002946	NAD(P) binding site [chemical binding]; other site
1204414002947	putative active site [active]
1204414002948	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1204414002949	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1204414002950	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1204414002951	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1204414002952	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414002953	Walker A/P-loop; other site
1204414002954	ATP binding site [chemical binding]; other site
1204414002955	Q-loop/lid; other site
1204414002956	AMP-binding domain protein; Validated; Region: PRK08315
1204414002957	Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867
1204414002958	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1204414002959	metal ion-dependent adhesion site (MIDAS); other site
1204414002960	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
1204414002961	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1204414002962	catalytic core [active]
1204414002963	conserved hypothetical protein; Region: TIGR03843
1204414002964	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1204414002965	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1204414002966	tetramer interface [polypeptide binding]; other site
1204414002967	active site
1204414002968	Mg2+/Mn2+ binding site [ion binding]; other site
1204414002969	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1204414002970	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414002971	Walker A/P-loop; other site
1204414002972	ATP binding site [chemical binding]; other site
1204414002973	Q-loop/lid; other site
1204414002974	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1204414002975	ABC transporter; Region: ABC_tran_2; pfam12848
1204414002976	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414002977	Walker A/P-loop; other site
1204414002978	ATP binding site [chemical binding]; other site
1204414002979	Q-loop/lid; other site
1204414002980	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
1204414002981	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
1204414002982	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
1204414002983	PhnA protein; Region: PhnA; pfam03831
1204414002984	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1204414002985	putative DNA binding site [nucleotide binding]; other site
1204414002986	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1204414002987	putative Zn2+ binding site [ion binding]; other site
1204414002988	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414002989	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1204414002990	putative substrate translocation pore; other site
1204414002991	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1204414002992	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1204414002993	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1204414002994	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1204414002995	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1204414002996	catalytic residue [active]
1204414002997	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543
1204414002998	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
1204414002999	dimerization interface [polypeptide binding]; other site
1204414003000	active site
1204414003001	quinolinate synthetase; Provisional; Region: PRK09375
1204414003002	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
1204414003003	nudix motif; other site
1204414003004	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
1204414003005	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
1204414003006	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1204414003007	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1204414003008	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1204414003009	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
1204414003010	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1204414003011	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1204414003012	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1204414003013	dimer interface [polypeptide binding]; other site
1204414003014	benzoate transport; Region: 2A0115; TIGR00895
1204414003015	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414003016	putative substrate translocation pore; other site
1204414003017	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414003018	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
1204414003019	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1204414003020	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1204414003021	ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721
1204414003022	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1204414003023	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1204414003024	Walker A/P-loop; other site
1204414003025	ATP binding site [chemical binding]; other site
1204414003026	Q-loop/lid; other site
1204414003027	ABC transporter signature motif; other site
1204414003028	Walker B; other site
1204414003029	D-loop; other site
1204414003030	H-loop/switch region; other site
1204414003031	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1204414003032	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
1204414003033	Walker A/P-loop; other site
1204414003034	ATP binding site [chemical binding]; other site
1204414003035	Q-loop/lid; other site
1204414003036	ABC transporter signature motif; other site
1204414003037	Walker B; other site
1204414003038	D-loop; other site
1204414003039	H-loop/switch region; other site
1204414003040	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1204414003041	hypothetical protein; Provisional; Region: PRK06547
1204414003042	Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563
1204414003043	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
1204414003044	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1204414003045	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
1204414003046	Predicted integral membrane protein [Function unknown]; Region: COG5522
1204414003047	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414003048	Walker A/P-loop; other site
1204414003049	ATP binding site [chemical binding]; other site
1204414003050	Q-loop/lid; other site
1204414003051	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
1204414003052	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414003053	ABC transporter signature motif; other site
1204414003054	Walker B; other site
1204414003055	D-loop; other site
1204414003056	H-loop/switch region; other site
1204414003057	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414003058	Walker A/P-loop; other site
1204414003059	ATP binding site [chemical binding]; other site
1204414003060	Q-loop/lid; other site
1204414003061	ABC transporter signature motif; other site
1204414003062	Walker B; other site
1204414003063	D-loop; other site
1204414003064	H-loop/switch region; other site
1204414003065	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1204414003066	dimer interface [polypeptide binding]; other site
1204414003067	catalytic triad [active]
1204414003068	peroxidatic and resolving cysteines [active]
1204414003069	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354
1204414003070	2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745
1204414003071	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1204414003072	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1204414003073	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424
1204414003074	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1204414003075	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
1204414003076	Trypsin; Region: Trypsin; pfam00089
1204414003077	active site
1204414003078	substrate binding sites [chemical binding]; other site
1204414003079	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
1204414003080	ArsC family; Region: ArsC; pfam03960
1204414003081	catalytic residues [active]
1204414003082	Uncharacterized membrane protein [Function unknown]; Region: COG3949
1204414003083	Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306
1204414003084	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1204414003085	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1204414003086	G1 box; other site
1204414003087	GTP/Mg2+ binding site [chemical binding]; other site
1204414003088	G2 box; other site
1204414003089	Switch I region; other site
1204414003090	G3 box; other site
1204414003091	Switch II region; other site
1204414003092	G4 box; other site
1204414003093	G5 box; other site
1204414003094	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1204414003095	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1204414003096	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
1204414003097	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1204414003098	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1204414003099	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
1204414003100	Ferredoxin [Energy production and conversion]; Region: COG1146
1204414003101	4Fe-4S binding domain; Region: Fer4; pfam00037
1204414003102	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
1204414003103	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1204414003104	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1204414003105	homodimer interface [polypeptide binding]; other site
1204414003106	catalytic residue [active]
1204414003107	Predicted membrane protein [Function unknown]; Region: COG2246
1204414003108	GtrA-like protein; Region: GtrA; pfam04138
1204414003109	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
1204414003110	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1204414003111	active site
1204414003112	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
1204414003113	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
1204414003114	putative trimer interface [polypeptide binding]; other site
1204414003115	putative CoA binding site [chemical binding]; other site
1204414003116	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
1204414003117	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
1204414003118	Tetrahydrodipicolinate N-succinyltransferase [Amino acid transport and metabolism]; Region: DapD; COG2171
1204414003119	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1204414003120	putative trimer interface [polypeptide binding]; other site
1204414003121	putative CoA binding site [chemical binding]; other site
1204414003122	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
1204414003123	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
1204414003124	metal binding site [ion binding]; metal-binding site
1204414003125	putative dimer interface [polypeptide binding]; other site
1204414003126	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
1204414003127	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1204414003128	dihydropteroate synthase; Region: DHPS; TIGR01496
1204414003129	substrate binding pocket [chemical binding]; other site
1204414003130	dimer interface [polypeptide binding]; other site
1204414003131	inhibitor binding site; inhibition site
1204414003132	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
1204414003133	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1204414003134	Protein of unknown function (DUF3117); Region: DUF3117; pfam11314
1204414003135	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1204414003136	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1204414003137	S-adenosylmethionine binding site [chemical binding]; other site
1204414003138	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
1204414003139	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1204414003140	active site
1204414003141	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1204414003142	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
1204414003143	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1204414003144	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
1204414003145	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1204414003146	ligand binding site; other site
1204414003147	oligomer interface; other site
1204414003148	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1204414003149	sulfate 1 binding site; other site
1204414003150	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1204414003151	Methyltransferase domain; Region: Methyltransf_24; pfam13578
1204414003152	RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647
1204414003153	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1204414003154	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1204414003155	DNA binding residues [nucleotide binding]
1204414003156	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806
1204414003157	sec-independent translocase; Provisional; Region: tatB; PRK00182
1204414003158	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
1204414003159	Domain of unknown function DUF59; Region: DUF59; pfam01883
1204414003160	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
1204414003161	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1204414003162	Predicted membrane protein [Function unknown]; Region: COG4420
1204414003163	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1204414003164	MgtE intracellular N domain; Region: MgtE_N; smart00924
1204414003165	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1204414003166	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1204414003167	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
1204414003168	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1204414003169	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1204414003170	TPP-binding site [chemical binding]; other site
1204414003171	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1204414003172	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1204414003173	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1204414003174	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414003175	Walker A/P-loop; other site
1204414003176	ATP binding site [chemical binding]; other site
1204414003177	Q-loop/lid; other site
1204414003178	ABC transporter signature motif; other site
1204414003179	Walker B; other site
1204414003180	D-loop; other site
1204414003181	H-loop/switch region; other site
1204414003182	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1204414003183	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1204414003184	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414003185	Walker A/P-loop; other site
1204414003186	ATP binding site [chemical binding]; other site
1204414003187	Q-loop/lid; other site
1204414003188	ABC transporter signature motif; other site
1204414003189	Walker B; other site
1204414003190	D-loop; other site
1204414003191	H-loop/switch region; other site
1204414003192	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
1204414003193	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1204414003194	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1204414003195	shikimate binding site; other site
1204414003196	NAD(P) binding site [chemical binding]; other site
1204414003197	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
1204414003198	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1204414003199	substrate binding pocket [chemical binding]; other site
1204414003200	catalytic triad [active]
1204414003201	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
1204414003202	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414003203	putative substrate translocation pore; other site
1204414003204	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1204414003205	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414003206	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414003207	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1204414003208	putative substrate translocation pore; other site
1204414003209	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
1204414003210	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
1204414003211	THF binding site; other site
1204414003212	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1204414003213	substrate binding site [chemical binding]; other site
1204414003214	THF binding site; other site
1204414003215	zinc-binding site [ion binding]; other site
1204414003216	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1204414003217	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1204414003218	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
1204414003219	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
1204414003220	active site
1204414003221	nucleophile elbow; other site
1204414003222	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1204414003223	Condensation domain; Region: Condensation; pfam00668
1204414003224	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1204414003225	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
1204414003226	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414003227	Q-loop/lid; other site
1204414003228	ABC transporter signature motif; other site
1204414003229	Walker B; other site
1204414003230	D-loop; other site
1204414003231	H-loop/switch region; other site
1204414003232	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
1204414003233	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1204414003234	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1204414003235	Walker A/P-loop; other site
1204414003236	ATP binding site [chemical binding]; other site
1204414003237	Q-loop/lid; other site
1204414003238	ABC transporter signature motif; other site
1204414003239	Walker B; other site
1204414003240	D-loop; other site
1204414003241	H-loop/switch region; other site
1204414003242	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1204414003243	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1204414003244	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1204414003245	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204
1204414003246	PLD-like domain; Region: PLDc_2; pfam13091
1204414003247	putative homodimer interface [polypeptide binding]; other site
1204414003248	putative active site [active]
1204414003249	catalytic site [active]
1204414003250	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1204414003251	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1204414003252	ATP binding site [chemical binding]; other site
1204414003253	putative Mg++ binding site [ion binding]; other site
1204414003254	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1204414003255	nucleotide binding region [chemical binding]; other site
1204414003256	ATP-binding site [chemical binding]; other site
1204414003257	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
1204414003258	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1204414003259	active site
1204414003260	8-oxo-dGMP binding site [chemical binding]; other site
1204414003261	nudix motif; other site
1204414003262	metal binding site [ion binding]; metal-binding site
1204414003263	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1204414003264	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1204414003265	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1204414003266	ATP binding site [chemical binding]; other site
1204414003267	Mg++ binding site [ion binding]; other site
1204414003268	motif III; other site
1204414003269	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1204414003270	nucleotide binding region [chemical binding]; other site
1204414003271	ATP-binding site [chemical binding]; other site
1204414003272	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
1204414003273	putative RNA binding site [nucleotide binding]; other site
1204414003274	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1204414003275	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1204414003276	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
1204414003277	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1204414003278	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1204414003279	Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177
1204414003280	active site
1204414003281	dimer interface [polypeptide binding]; other site
1204414003282	metal binding site [ion binding]; metal-binding site
1204414003283	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
1204414003284	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
1204414003285	active site
1204414003286	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
1204414003287	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1204414003288	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
1204414003289	Na binding site [ion binding]; other site
1204414003290	SNF2 Helicase protein; Region: DUF3670; pfam12419
1204414003291	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1204414003292	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1204414003293	putative Mg++ binding site [ion binding]; other site
1204414003294	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1204414003295	nucleotide binding region [chemical binding]; other site
1204414003296	ATP-binding site [chemical binding]; other site
1204414003297	Uncharacterized conserved protein [Function unknown]; Region: COG4279
1204414003298	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
1204414003299	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1204414003300	active site
1204414003301	metal binding site [ion binding]; metal-binding site
1204414003302	DNA binding site [nucleotide binding]
1204414003303	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
1204414003304	Uncharacterized conserved protein [Function unknown]; Region: COG4717
1204414003305	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1204414003306	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
1204414003307	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
1204414003308	Uncharacterized conserved protein [Function unknown]; Region: COG2353
1204414003309	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1204414003310	MarR family; Region: MarR_2; pfam12802
1204414003311	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
1204414003312	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1204414003313	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1204414003314	ligand binding site [chemical binding]; other site
1204414003315	flexible hinge region; other site
1204414003316	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1204414003317	non-specific DNA interactions [nucleotide binding]; other site
1204414003318	DNA binding site [nucleotide binding]
1204414003319	sequence specific DNA binding site [nucleotide binding]; other site
1204414003320	putative cAMP binding site [chemical binding]; other site
1204414003321	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1204414003322	metal-binding site [ion binding]
1204414003323	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
1204414003324	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1204414003325	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1204414003326	motif II; other site
1204414003327	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1204414003328	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1204414003329	synthetase active site [active]
1204414003330	NTP binding site [chemical binding]; other site
1204414003331	metal binding site [ion binding]; metal-binding site
1204414003332	TAP-like protein; Region: Abhydrolase_4; pfam08386
1204414003333	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
1204414003334	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1204414003335	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1204414003336	active site
1204414003337	HIGH motif; other site
1204414003338	KMSK motif region; other site
1204414003339	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1204414003340	tRNA binding surface [nucleotide binding]; other site
1204414003341	anticodon binding site; other site
1204414003342	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1204414003343	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1204414003344	active site
1204414003345	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1204414003346	substrate binding site [chemical binding]; other site
1204414003347	catalytic residues [active]
1204414003348	dimer interface [polypeptide binding]; other site
1204414003349	homoserine dehydrogenase; Provisional; Region: PRK06349
1204414003350	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1204414003351	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1204414003352	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
1204414003353	homoserine kinase; Provisional; Region: PRK01212
1204414003354	Predicted transcriptional regulator [Transcription]; Region: COG2345
1204414003355	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
1204414003356	Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
1204414003357	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
1204414003358	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
1204414003359	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
1204414003360	[4Fe-4S] binding site [ion binding]; other site
1204414003361	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1204414003362	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1204414003363	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1204414003364	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
1204414003365	molybdopterin cofactor binding site; other site
1204414003366	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
1204414003367	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1204414003368	MPT binding site; other site
1204414003369	trimer interface [polypeptide binding]; other site
1204414003370	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
1204414003371	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1204414003372	active site
1204414003373	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
1204414003374	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1204414003375	Domain of unknown function DUF21; Region: DUF21; pfam01595
1204414003376	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1204414003377	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1204414003378	Domain of unknown function DUF21; Region: DUF21; pfam01595
1204414003379	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1204414003380	Transporter associated domain; Region: CorC_HlyC; pfam03471
1204414003381	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1204414003382	GTP binding site; other site
1204414003383	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1204414003384	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1204414003385	dimer interface [polypeptide binding]; other site
1204414003386	putative functional site; other site
1204414003387	putative MPT binding site; other site
1204414003388	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
1204414003389	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1204414003390	FeS/SAM binding site; other site
1204414003391	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1204414003392	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620
1204414003393	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
1204414003394	dimer interface [polypeptide binding]; other site
1204414003395	acyl-activating enzyme (AAE) consensus motif; other site
1204414003396	putative active site [active]
1204414003397	AMP binding site [chemical binding]; other site
1204414003398	putative CoA binding site [chemical binding]; other site
1204414003399	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
1204414003400	transcription termination factor Rho; Provisional; Region: PRK12608
1204414003401	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1204414003402	RNA binding site [nucleotide binding]; other site
1204414003403	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1204414003404	multimer interface [polypeptide binding]; other site
1204414003405	Walker A motif; other site
1204414003406	ATP binding site [chemical binding]; other site
1204414003407	Walker B motif; other site
1204414003408	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1204414003409	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1204414003410	RF-1 domain; Region: RF-1; pfam00472
1204414003411	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1204414003412	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1204414003413	S-adenosylmethionine binding site [chemical binding]; other site
1204414003414	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
1204414003415	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1204414003416	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1204414003417	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1204414003418	Mg++ binding site [ion binding]; other site
1204414003419	putative catalytic motif [active]
1204414003420	substrate binding site [chemical binding]; other site
1204414003421	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1204414003422	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1204414003423	F0F1 ATP synthase subunit C; Validated; Region: PRK07874
1204414003424	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1204414003425	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1204414003426	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430
1204414003427	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1204414003428	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1204414003429	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1204414003430	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1204414003431	beta subunit interaction interface [polypeptide binding]; other site
1204414003432	Walker A motif; other site
1204414003433	ATP binding site [chemical binding]; other site
1204414003434	Walker B motif; other site
1204414003435	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1204414003436	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1204414003437	core domain interface [polypeptide binding]; other site
1204414003438	delta subunit interface [polypeptide binding]; other site
1204414003439	epsilon subunit interface [polypeptide binding]; other site
1204414003440	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1204414003441	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1204414003442	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1204414003443	alpha subunit interaction interface [polypeptide binding]; other site
1204414003444	Walker A motif; other site
1204414003445	ATP binding site [chemical binding]; other site
1204414003446	Walker B motif; other site
1204414003447	inhibitor binding site; inhibition site
1204414003448	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1204414003449	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
1204414003450	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1204414003451	gamma subunit interface [polypeptide binding]; other site
1204414003452	epsilon subunit interface [polypeptide binding]; other site
1204414003453	LBP interface [polypeptide binding]; other site
1204414003454	Protein of unknown function (DUF2550); Region: DUF2550; pfam10739
1204414003455	Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637
1204414003456	hypothetical protein; Provisional; Region: PRK03298
1204414003457	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
1204414003458	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1204414003459	dimer interface [polypeptide binding]; other site
1204414003460	substrate binding site [chemical binding]; other site
1204414003461	metal binding site [ion binding]; metal-binding site
1204414003462	Uncharacterized conserved protein [Function unknown]; Region: COG0011
1204414003463	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
1204414003464	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
1204414003465	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1204414003466	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
1204414003467	dimer interface [polypeptide binding]; other site
1204414003468	active site
1204414003469	non-prolyl cis peptide bond; other site
1204414003470	insertion regions; other site
1204414003471	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1204414003472	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1204414003473	dimer interface [polypeptide binding]; other site
1204414003474	conserved gate region; other site
1204414003475	putative PBP binding loops; other site
1204414003476	ABC-ATPase subunit interface; other site
1204414003477	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1204414003478	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1204414003479	Walker A/P-loop; other site
1204414003480	ATP binding site [chemical binding]; other site
1204414003481	Q-loop/lid; other site
1204414003482	ABC transporter signature motif; other site
1204414003483	Walker B; other site
1204414003484	D-loop; other site
1204414003485	H-loop/switch region; other site
1204414003486	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1204414003487	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1204414003488	substrate binding pocket [chemical binding]; other site
1204414003489	membrane-bound complex binding site; other site
1204414003490	hinge residues; other site
1204414003491	Domain of unknown function (DUF4303); Region: DUF4303; pfam14136
1204414003492	glycogen branching enzyme; Provisional; Region: PRK05402
1204414003493	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
1204414003494	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
1204414003495	active site
1204414003496	catalytic site [active]
1204414003497	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
1204414003498	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
1204414003499	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
1204414003500	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1204414003501	active site
1204414003502	catalytic site [active]
1204414003503	ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119
1204414003504	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414003505	Walker A/P-loop; other site
1204414003506	ATP binding site [chemical binding]; other site
1204414003507	Q-loop/lid; other site
1204414003508	ABC transporter signature motif; other site
1204414003509	Walker B; other site
1204414003510	D-loop; other site
1204414003511	H-loop/switch region; other site
1204414003512	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1204414003513	Ligand binding site [chemical binding]; other site
1204414003514	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1204414003515	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1204414003516	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1204414003517	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1204414003518	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1204414003519	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1204414003520	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1204414003521	catalytic residue [active]
1204414003522	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
1204414003523	HipA N-terminal domain; Region: couple_hipA; TIGR03071
1204414003524	HipA-like N-terminal domain; Region: HipA_N; pfam07805
1204414003525	HipA-like C-terminal domain; Region: HipA_C; pfam07804
1204414003526	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1204414003527	salt bridge; other site
1204414003528	non-specific DNA binding site [nucleotide binding]; other site
1204414003529	sequence-specific DNA binding site [nucleotide binding]; other site
1204414003530	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1204414003531	Coenzyme A binding pocket [chemical binding]; other site
1204414003532	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1204414003533	S-adenosylmethionine binding site [chemical binding]; other site
1204414003534	AAA ATPase domain; Region: AAA_16; pfam13191
1204414003535	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
1204414003536	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1204414003537	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
1204414003538	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1204414003539	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
1204414003540	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414003541	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1204414003542	putative substrate translocation pore; other site
1204414003543	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414003544	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1204414003545	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1204414003546	active site
1204414003547	catalytic site [active]
1204414003548	substrate binding site [chemical binding]; other site
1204414003549	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1204414003550	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1204414003551	nucleotide binding pocket [chemical binding]; other site
1204414003552	K-X-D-G motif; other site
1204414003553	catalytic site [active]
1204414003554	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1204414003555	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1204414003556	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1204414003557	Dimer interface [polypeptide binding]; other site
1204414003558	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1204414003559	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1204414003560	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1204414003561	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1204414003562	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
1204414003563	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
1204414003564	FAD binding pocket [chemical binding]; other site
1204414003565	FAD binding motif [chemical binding]; other site
1204414003566	phosphate binding motif [ion binding]; other site
1204414003567	NAD binding pocket [chemical binding]; other site
1204414003568	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
1204414003569	phosphofructokinase; Region: PFK_mixed; TIGR02483
1204414003570	active site
1204414003571	ADP/pyrophosphate binding site [chemical binding]; other site
1204414003572	dimerization interface [polypeptide binding]; other site
1204414003573	allosteric effector site; other site
1204414003574	fructose-1,6-bisphosphate binding site; other site
1204414003575	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1204414003576	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1204414003577	DNA binding site [nucleotide binding]
1204414003578	domain linker motif; other site
1204414003579	Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299
1204414003580	dimerization interface [polypeptide binding]; other site
1204414003581	putative ligand binding site [chemical binding]; other site
1204414003582	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1204414003583	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1204414003584	Walker A/P-loop; other site
1204414003585	ATP binding site [chemical binding]; other site
1204414003586	Q-loop/lid; other site
1204414003587	ABC transporter signature motif; other site
1204414003588	Walker B; other site
1204414003589	D-loop; other site
1204414003590	H-loop/switch region; other site
1204414003591	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1204414003592	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1204414003593	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1204414003594	TM-ABC transporter signature motif; other site
1204414003595	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
1204414003596	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1204414003597	ligand binding site [chemical binding]; other site
1204414003598	dimerization interface [polypeptide binding]; other site
1204414003599	D-ribose pyranase; Provisional; Region: PRK11797
1204414003600	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1204414003601	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1204414003602	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1204414003603	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1204414003604	siderophore binding site; other site
1204414003605	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1204414003606	Sodium Bile acid symporter family; Region: SBF; pfam01758
1204414003607	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1204414003608	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1204414003609	GatB domain; Region: GatB_Yqey; pfam02637
1204414003610	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
1204414003611	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1204414003612	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1204414003613	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1204414003614	active site
1204414003615	catalytic tetrad [active]
1204414003616	L-lysine exporter; Region: 2a75; TIGR00948
1204414003617	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
1204414003618	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1204414003619	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1204414003620	dimerization interface [polypeptide binding]; other site
1204414003621	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
1204414003622	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
1204414003623	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
1204414003624	putative dimer interface [polypeptide binding]; other site
1204414003625	N-terminal domain interface [polypeptide binding]; other site
1204414003626	putative substrate binding pocket (H-site) [chemical binding]; other site
1204414003627	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
1204414003628	Predicted membrane protein [Function unknown]; Region: COG2259
1204414003629	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
1204414003630	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
1204414003631	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1204414003632	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1204414003633	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
1204414003634	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1204414003635	PYR/PP interface [polypeptide binding]; other site
1204414003636	dimer interface [polypeptide binding]; other site
1204414003637	TPP binding site [chemical binding]; other site
1204414003638	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1204414003639	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1204414003640	TPP-binding site [chemical binding]; other site
1204414003641	dimer interface [polypeptide binding]; other site
1204414003642	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1204414003643	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1204414003644	putative valine binding site [chemical binding]; other site
1204414003645	dimer interface [polypeptide binding]; other site
1204414003646	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1204414003647	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1204414003648	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1204414003649	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1204414003650	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1204414003651	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414003652	ABC transporter signature motif; other site
1204414003653	Walker B; other site
1204414003654	D-loop; other site
1204414003655	H-loop/switch region; other site
1204414003656	Protein of unknown function (DUF1602); Region: DUF1602; pfam07673
1204414003657	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1204414003658	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414003659	Walker A/P-loop; other site
1204414003660	ATP binding site [chemical binding]; other site
1204414003661	Q-loop/lid; other site
1204414003662	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1204414003663	NMT1-like family; Region: NMT1_2; pfam13379
1204414003664	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
1204414003665	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1204414003666	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1204414003667	Uncharacterized conserved protein [Function unknown]; Region: COG1479
1204414003668	Protein of unknown function DUF262; Region: DUF262; pfam03235
1204414003669	Uncharacterized conserved protein [Function unknown]; Region: COG3472
1204414003670	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1204414003671	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
1204414003672	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
1204414003673	ligand binding site [chemical binding]; other site
1204414003674	NAD binding site [chemical binding]; other site
1204414003675	dimerization interface [polypeptide binding]; other site
1204414003676	catalytic site [active]
1204414003677	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
1204414003678	putative L-serine binding site [chemical binding]; other site
1204414003679	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
1204414003680	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
1204414003681	tartrate dehydrogenase; Region: TTC; TIGR02089
1204414003682	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1204414003683	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1204414003684	membrane-bound complex binding site; other site
1204414003685	hinge residues; other site
1204414003686	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
1204414003687	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1204414003688	ligand binding site [chemical binding]; other site
1204414003689	flexible hinge region; other site
1204414003690	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
1204414003691	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1204414003692	metal binding triad; other site
1204414003693	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1204414003694	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1204414003695	active site
1204414003696	catalytic site [active]
1204414003697	substrate binding site [chemical binding]; other site
1204414003698	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
1204414003699	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1204414003700	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1204414003701	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1204414003702	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1204414003703	S-adenosylmethionine binding site [chemical binding]; other site
1204414003704	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
1204414003705	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1204414003706	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1204414003707	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1204414003708	active site
1204414003709	HIGH motif; other site
1204414003710	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1204414003711	active site
1204414003712	KMSKS motif; other site
1204414003713	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1204414003714	salt bridge; other site
1204414003715	non-specific DNA binding site [nucleotide binding]; other site
1204414003716	sequence-specific DNA binding site [nucleotide binding]; other site
1204414003717	Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
1204414003718	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822
1204414003719	putative hydrophobic ligand binding site [chemical binding]; other site
1204414003720	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1204414003721	WHG domain; Region: WHG; pfam13305
1204414003722	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822
1204414003723	putative hydrophobic ligand binding site [chemical binding]; other site
1204414003724	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1204414003725	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
1204414003726	ThiC-associated domain; Region: ThiC-associated; pfam13667
1204414003727	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
1204414003728	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
1204414003729	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
1204414003730	homodimer interface [polypeptide binding]; other site
1204414003731	active site pocket [active]
1204414003732	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1204414003733	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1204414003734	active site residue [active]
1204414003735	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1204414003736	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1204414003737	HD domain; Region: HD_4; pfam13328
1204414003738	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1204414003739	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
1204414003740	Bacterial transcriptional regulator; Region: IclR; pfam01614
1204414003741	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1204414003742	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1204414003743	substrate binding site [chemical binding]; other site
1204414003744	ligand binding site [chemical binding]; other site
1204414003745	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1204414003746	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1204414003747	substrate binding site [chemical binding]; other site
1204414003748	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
1204414003749	active site
1204414003750	Ap6A binding site [chemical binding]; other site
1204414003751	nudix motif; other site
1204414003752	metal binding site [ion binding]; metal-binding site
1204414003753	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1204414003754	catalytic core [active]
1204414003755	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1204414003756	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1204414003757	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1204414003758	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1204414003759	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1204414003760	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1204414003761	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
1204414003762	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
1204414003763	thiamine monophosphate kinase; Provisional; Region: PRK05731
1204414003764	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
1204414003765	ATP binding site [chemical binding]; other site
1204414003766	dimerization interface [polypeptide binding]; other site
1204414003767	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1204414003768	ligand binding site [chemical binding]; other site
1204414003769	active site
1204414003770	UGI interface [polypeptide binding]; other site
1204414003771	catalytic site [active]
1204414003772	Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461
1204414003773	DAK2 domain; Region: Dak2; pfam02734
1204414003774	RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200
1204414003775	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1204414003776	generic binding surface II; other site
1204414003777	ssDNA binding site; other site
1204414003778	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1204414003779	ATP binding site [chemical binding]; other site
1204414003780	putative Mg++ binding site [ion binding]; other site
1204414003781	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1204414003782	nucleotide binding region [chemical binding]; other site
1204414003783	ATP-binding site [chemical binding]; other site
1204414003784	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
1204414003785	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1204414003786	carboxyltransferase (CT) interaction site; other site
1204414003787	biotinylation site [posttranslational modification]; other site
1204414003788	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
1204414003789	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1204414003790	S-adenosylmethionine binding site [chemical binding]; other site
1204414003791	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1204414003792	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1204414003793	active site
1204414003794	(T/H)XGH motif; other site
1204414003795	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1204414003796	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1204414003797	Walker A/P-loop; other site
1204414003798	ATP binding site [chemical binding]; other site
1204414003799	Q-loop/lid; other site
1204414003800	ABC transporter signature motif; other site
1204414003801	Walker B; other site
1204414003802	D-loop; other site
1204414003803	H-loop/switch region; other site
1204414003804	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1204414003805	dimer interface [polypeptide binding]; other site
1204414003806	conserved gate region; other site
1204414003807	putative PBP binding loops; other site
1204414003808	ABC-ATPase subunit interface; other site
1204414003809	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1204414003810	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1204414003811	substrate binding pocket [chemical binding]; other site
1204414003812	membrane-bound complex binding site; other site
1204414003813	hinge residues; other site
1204414003814	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
1204414003815	Domain of unknown function (DUF368); Region: DUF368; pfam04018
1204414003816	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1204414003817	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1204414003818	active site
1204414003819	DNA binding site [nucleotide binding]
1204414003820	Int/Topo IB signature motif; other site
1204414003821	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
1204414003822	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4815
1204414003823	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
1204414003824	Uncharacterized conserved small protein [Function unknown]; Region: COG5428
1204414003825	Integrase core domain; Region: rve_3; cl15866
1204414003826	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
1204414003827	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
1204414003828	DNA polymerase I; Provisional; Region: PRK05755
1204414003829	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1204414003830	active site
1204414003831	metal binding site 1 [ion binding]; metal-binding site
1204414003832	putative 5' ssDNA interaction site; other site
1204414003833	metal binding site 3; metal-binding site
1204414003834	metal binding site 2 [ion binding]; metal-binding site
1204414003835	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1204414003836	putative DNA binding site [nucleotide binding]; other site
1204414003837	putative metal binding site [ion binding]; other site
1204414003838	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
1204414003839	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1204414003840	active site
1204414003841	DNA binding site [nucleotide binding]
1204414003842	catalytic site [active]
1204414003843	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414003844	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1204414003845	putative substrate translocation pore; other site
1204414003846	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414003847	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1204414003848	salt bridge; other site
1204414003849	non-specific DNA binding site [nucleotide binding]; other site
1204414003850	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1204414003851	sequence-specific DNA binding site [nucleotide binding]; other site
1204414003852	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1204414003853	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1204414003854	active site
1204414003855	catalytic tetrad [active]
1204414003856	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
1204414003857	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1204414003858	S-adenosylmethionine binding site [chemical binding]; other site
1204414003859	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
1204414003860	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1204414003861	RNA binding site [nucleotide binding]; other site
1204414003862	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1204414003863	RNA binding site [nucleotide binding]; other site
1204414003864	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1204414003865	RNA binding site [nucleotide binding]; other site
1204414003866	S1 RNA binding domain; Region: S1; pfam00575
1204414003867	RNA binding site [nucleotide binding]; other site
1204414003868	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1204414003869	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
1204414003870	active site turn [active]
1204414003871	phosphorylation site [posttranslational modification]
1204414003872	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1204414003873	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1204414003874	HPr interaction site; other site
1204414003875	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1204414003876	active site
1204414003877	phosphorylation site [posttranslational modification]
1204414003878	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1204414003879	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1204414003880	CoA-binding site [chemical binding]; other site
1204414003881	ATP-binding [chemical binding]; other site
1204414003882	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
1204414003883	active site
1204414003884	tetramer interface [polypeptide binding]; other site
1204414003885	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1204414003886	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414003887	putative substrate translocation pore; other site
1204414003888	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1204414003889	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1204414003890	substrate binding site [chemical binding]; other site
1204414003891	dimer interface [polypeptide binding]; other site
1204414003892	ATP binding site [chemical binding]; other site
1204414003893	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1204414003894	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1204414003895	DNA binding site [nucleotide binding]
1204414003896	domain linker motif; other site
1204414003897	Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299
1204414003898	dimerization interface [polypeptide binding]; other site
1204414003899	putative ligand binding site [chemical binding]; other site
1204414003900	excinuclease ABC subunit B; Provisional; Region: PRK05298
1204414003901	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1204414003902	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1204414003903	nucleotide binding region [chemical binding]; other site
1204414003904	ATP-binding site [chemical binding]; other site
1204414003905	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1204414003906	UvrB/uvrC motif; Region: UVR; pfam02151
1204414003907	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1204414003908	Ligand Binding Site [chemical binding]; other site
1204414003909	Predicted transcriptional regulators [Transcription]; Region: COG1733
1204414003910	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1204414003911	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1204414003912	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
1204414003913	NADP binding site [chemical binding]; other site
1204414003914	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
1204414003915	Part of AAA domain; Region: AAA_19; pfam13245
1204414003916	Family description; Region: UvrD_C_2; pfam13538
1204414003917	Predicted membrane protein [Function unknown]; Region: COG2259
1204414003918	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1204414003919	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1204414003920	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1204414003921	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1204414003922	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1204414003923	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
1204414003924	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1204414003925	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1204414003926	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1204414003927	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1204414003928	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1204414003929	23S rRNA binding site [nucleotide binding]; other site
1204414003930	L21 binding site [polypeptide binding]; other site
1204414003931	L13 binding site [polypeptide binding]; other site
1204414003932	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446
1204414003933	GIY-YIG motif/motif A; other site
1204414003934	putative active site [active]
1204414003935	putative metal binding site [ion binding]; other site
1204414003936	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1204414003937	dimer interface [polypeptide binding]; other site
1204414003938	conserved gate region; other site
1204414003939	putative PBP binding loops; other site
1204414003940	ABC-ATPase subunit interface; other site
1204414003941	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1204414003942	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1204414003943	dimer interface [polypeptide binding]; other site
1204414003944	conserved gate region; other site
1204414003945	putative PBP binding loops; other site
1204414003946	ABC-ATPase subunit interface; other site
1204414003947	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1204414003948	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1204414003949	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1204414003950	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1204414003951	Walker A/P-loop; other site
1204414003952	ATP binding site [chemical binding]; other site
1204414003953	Q-loop/lid; other site
1204414003954	ABC transporter signature motif; other site
1204414003955	Walker B; other site
1204414003956	D-loop; other site
1204414003957	H-loop/switch region; other site
1204414003958	TOBE domain; Region: TOBE_2; pfam08402
1204414003959	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1204414003960	Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
1204414003961	active site
1204414003962	catalytic site [active]
1204414003963	metal binding site [ion binding]; metal-binding site
1204414003964	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1204414003965	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1204414003966	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1204414003967	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1204414003968	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1204414003969	dimer interface [polypeptide binding]; other site
1204414003970	motif 1; other site
1204414003971	active site
1204414003972	motif 2; other site
1204414003973	motif 3; other site
1204414003974	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1204414003975	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1204414003976	putative tRNA-binding site [nucleotide binding]; other site
1204414003977	B3/4 domain; Region: B3_4; pfam03483
1204414003978	tRNA synthetase B5 domain; Region: B5; smart00874
1204414003979	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1204414003980	dimer interface [polypeptide binding]; other site
1204414003981	motif 1; other site
1204414003982	motif 3; other site
1204414003983	motif 2; other site
1204414003984	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1204414003985	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
1204414003986	active site
1204414003987	catalytic triad [active]
1204414003988	oxyanion hole [active]
1204414003989	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1204414003990	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
1204414003991	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1204414003992	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1204414003993	heterotetramer interface [polypeptide binding]; other site
1204414003994	active site pocket [active]
1204414003995	cleavage site
1204414003996	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
1204414003997	feedback inhibition sensing region; other site
1204414003998	homohexameric interface [polypeptide binding]; other site
1204414003999	nucleotide binding site [chemical binding]; other site
1204414004000	N-acetyl-L-glutamate binding site [chemical binding]; other site
1204414004001	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
1204414004002	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1204414004003	inhibitor-cofactor binding pocket; inhibition site
1204414004004	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1204414004005	catalytic residue [active]
1204414004006	ornithine carbamoyltransferase; Provisional; Region: PRK00779
1204414004007	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1204414004008	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1204414004009	arginine repressor; Provisional; Region: PRK03341
1204414004010	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1204414004011	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1204414004012	argininosuccinate synthase; Provisional; Region: PRK13820
1204414004013	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1204414004014	ANP binding site [chemical binding]; other site
1204414004015	Substrate Binding Site II [chemical binding]; other site
1204414004016	Substrate Binding Site I [chemical binding]; other site
1204414004017	argininosuccinate lyase; Provisional; Region: PRK00855
1204414004018	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1204414004019	active sites [active]
1204414004020	tetramer interface [polypeptide binding]; other site
1204414004021	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
1204414004022	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1204414004023	metal ion-dependent adhesion site (MIDAS); other site
1204414004024	Uncharacterized conserved protein [Function unknown]; Region: COG2835
1204414004025	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1204414004026	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1204414004027	active site
1204414004028	HIGH motif; other site
1204414004029	dimer interface [polypeptide binding]; other site
1204414004030	KMSKS motif; other site
1204414004031	S4 RNA-binding domain; Region: S4; smart00363
1204414004032	RNA binding surface [nucleotide binding]; other site
1204414004033	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1204414004034	Ligand Binding Site [chemical binding]; other site
1204414004035	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
1204414004036	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
1204414004037	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1204414004038	active site
1204414004039	motif I; other site
1204414004040	motif II; other site
1204414004041	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1204414004042	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
1204414004043	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1204414004044	RNA binding surface [nucleotide binding]; other site
1204414004045	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1204414004046	S-adenosylmethionine binding site [chemical binding]; other site
1204414004047	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372
1204414004048	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
1204414004049	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1204414004050	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1204414004051	Walker A/P-loop; other site
1204414004052	ATP binding site [chemical binding]; other site
1204414004053	Q-loop/lid; other site
1204414004054	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1204414004055	ABC transporter signature motif; other site
1204414004056	Walker B; other site
1204414004057	D-loop; other site
1204414004058	H-loop/switch region; other site
1204414004059	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
1204414004060	Thiamine pyrophosphokinase; Region: TPK; cl08415
1204414004061	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
1204414004062	CTP synthetase; Validated; Region: pyrG; PRK05380
1204414004063	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1204414004064	Catalytic site [active]
1204414004065	active site
1204414004066	UTP binding site [chemical binding]; other site
1204414004067	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1204414004068	active site
1204414004069	putative oxyanion hole; other site
1204414004070	catalytic triad [active]
1204414004071	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1204414004072	dimer interface [polypeptide binding]; other site
1204414004073	ADP-ribose binding site [chemical binding]; other site
1204414004074	active site
1204414004075	nudix motif; other site
1204414004076	metal binding site [ion binding]; metal-binding site
1204414004077	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
1204414004078	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1204414004079	active site
1204414004080	Int/Topo IB signature motif; other site
1204414004081	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1204414004082	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414004083	Walker A/P-loop; other site
1204414004084	ATP binding site [chemical binding]; other site
1204414004085	Q-loop/lid; other site
1204414004086	ABC transporter signature motif; other site
1204414004087	Walker B; other site
1204414004088	D-loop; other site
1204414004089	H-loop/switch region; other site
1204414004090	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1204414004091	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1204414004092	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1204414004093	P-loop; other site
1204414004094	Magnesium ion binding site [ion binding]; other site
1204414004095	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1204414004096	Magnesium ion binding site [ion binding]; other site
1204414004097	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
1204414004098	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1204414004099	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1204414004100	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1204414004101	active site residue [active]
1204414004102	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1204414004103	active site residue [active]
1204414004104	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
1204414004105	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1204414004106	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1204414004107	RNA binding surface [nucleotide binding]; other site
1204414004108	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1204414004109	active site
1204414004110	cytidylate kinase; Provisional; Region: cmk; PRK00023
1204414004111	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1204414004112	CMP-binding site; other site
1204414004113	The sites determining sugar specificity; other site
1204414004114	GTP-binding protein Der; Reviewed; Region: PRK03003
1204414004115	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1204414004116	G1 box; other site
1204414004117	GTP/Mg2+ binding site [chemical binding]; other site
1204414004118	Switch I region; other site
1204414004119	G2 box; other site
1204414004120	Switch II region; other site
1204414004121	G3 box; other site
1204414004122	G4 box; other site
1204414004123	G5 box; other site
1204414004124	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1204414004125	G1 box; other site
1204414004126	GTP/Mg2+ binding site [chemical binding]; other site
1204414004127	Switch I region; other site
1204414004128	G2 box; other site
1204414004129	G3 box; other site
1204414004130	Switch II region; other site
1204414004131	G4 box; other site
1204414004132	G5 box; other site
1204414004133	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1204414004134	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1204414004135	Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978
1204414004136	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1204414004137	S-adenosylmethionine binding site [chemical binding]; other site
1204414004138	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1204414004139	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1204414004140	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414004141	Walker B; other site
1204414004142	D-loop; other site
1204414004143	H-loop/switch region; other site
1204414004144	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1204414004145	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1204414004146	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414004147	Walker A/P-loop; other site
1204414004148	ATP binding site [chemical binding]; other site
1204414004149	Q-loop/lid; other site
1204414004150	ABC transporter signature motif; other site
1204414004151	Walker B; other site
1204414004152	D-loop; other site
1204414004153	H-loop/switch region; other site
1204414004154	zinc transporter ZupT; Provisional; Region: PRK04201
1204414004155	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1204414004156	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012
1204414004157	SEC-C motif; Region: SEC-C; pfam02810
1204414004158	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1204414004159	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
1204414004160	preprotein translocase subunit SecA; Reviewed; Region: PRK12326
1204414004161	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
1204414004162	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
1204414004163	nucleotide binding region [chemical binding]; other site
1204414004164	ATP-binding site [chemical binding]; other site
1204414004165	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1204414004166	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1204414004167	phosphopeptide binding site; other site
1204414004168	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
1204414004169	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1204414004170	DNA binding residues [nucleotide binding]
1204414004171	Uncharacterized conserved protein [Function unknown]; Region: COG1259
1204414004172	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1204414004173	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1204414004174	DNA binding residues [nucleotide binding]
1204414004175	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
1204414004176	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1204414004177	Domain of unknown function DUF21; Region: DUF21; pfam01595
1204414004178	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1204414004179	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1204414004180	Domain of unknown function DUF21; Region: DUF21; pfam01595
1204414004181	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1204414004182	Transporter associated domain; Region: CorC_HlyC; smart01091
1204414004183	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1204414004184	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1204414004185	ATP binding site [chemical binding]; other site
1204414004186	putative Mg++ binding site [ion binding]; other site
1204414004187	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1204414004188	nucleotide binding region [chemical binding]; other site
1204414004189	ATP-binding site [chemical binding]; other site
1204414004190	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
1204414004191	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
1204414004192	FAD binding pocket [chemical binding]; other site
1204414004193	FAD binding motif [chemical binding]; other site
1204414004194	phosphate binding motif [ion binding]; other site
1204414004195	NAD binding pocket [chemical binding]; other site
1204414004196	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1204414004197	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1204414004198	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1204414004199	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1204414004200	CoenzymeA binding site [chemical binding]; other site
1204414004201	subunit interaction site [polypeptide binding]; other site
1204414004202	PHB binding site; other site
1204414004203	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1204414004204	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1204414004205	S-adenosylmethionine binding site [chemical binding]; other site
1204414004206	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1204414004207	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1204414004208	Walker A/P-loop; other site
1204414004209	ATP binding site [chemical binding]; other site
1204414004210	Q-loop/lid; other site
1204414004211	ABC transporter signature motif; other site
1204414004212	Walker B; other site
1204414004213	D-loop; other site
1204414004214	H-loop/switch region; other site
1204414004215	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1204414004216	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1204414004217	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1204414004218	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1204414004219	dimer interface [polypeptide binding]; other site
1204414004220	conserved gate region; other site
1204414004221	ABC-ATPase subunit interface; other site
1204414004222	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1204414004223	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1204414004224	dimer interface [polypeptide binding]; other site
1204414004225	conserved gate region; other site
1204414004226	ABC-ATPase subunit interface; other site
1204414004227	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
1204414004228	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
1204414004229	Walker A/P-loop; other site
1204414004230	ATP binding site [chemical binding]; other site
1204414004231	Q-loop/lid; other site
1204414004232	ABC transporter signature motif; other site
1204414004233	Walker B; other site
1204414004234	D-loop; other site
1204414004235	H-loop/switch region; other site
1204414004236	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
1204414004237	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1204414004238	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1204414004239	motif I; other site
1204414004240	active site
1204414004241	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1204414004242	motif II; other site
1204414004243	multifunctional hydroxymethylpyrimidine phosphokinase/4-amino-5-aminomethyl-2-methylpyrimidine hydrolase; Provisional; Region: PRK14713
1204414004244	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1204414004245	dimer interface [polypeptide binding]; other site
1204414004246	substrate binding site [chemical binding]; other site
1204414004247	ATP binding site [chemical binding]; other site
1204414004248	Putative transcription activator [Transcription]; Region: TenA; COG0819
1204414004249	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
1204414004250	substrate binding site [chemical binding]; other site
1204414004251	multimerization interface [polypeptide binding]; other site
1204414004252	ATP binding site [chemical binding]; other site
1204414004253	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1204414004254	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1204414004255	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1204414004256	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
1204414004257	metabolite-proton symporter; Region: 2A0106; TIGR00883
1204414004258	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414004259	putative substrate translocation pore; other site
1204414004260	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
1204414004261	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1204414004262	active site
1204414004263	Predicted membrane protein [Function unknown]; Region: COG1971
1204414004264	Domain of unknown function DUF; Region: DUF204; pfam02659
1204414004265	Domain of unknown function DUF; Region: DUF204; pfam02659
1204414004266	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
1204414004267	Sodium Bile acid symporter family; Region: SBF; cl17470
1204414004268	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
1204414004269	A new structural DNA glycosylase; Region: AlkD_like; cd06561
1204414004270	active site
1204414004271	high affinity sulphate transporter 1; Region: sulP; TIGR00815
1204414004272	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1204414004273	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1204414004274	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1204414004275	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
1204414004276	Uncharacterized conserved protein [Function unknown]; Region: COG2353
1204414004277	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
1204414004278	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
1204414004279	Ligand binding site; other site
1204414004280	Putative Catalytic site; other site
1204414004281	DXD motif; other site
1204414004282	Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
1204414004283	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
1204414004284	putative active site [active]
1204414004285	catalytic triad [active]
1204414004286	putative dimer interface [polypeptide binding]; other site
1204414004287	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
1204414004288	Secretory lipase; Region: LIP; pfam03583
1204414004289	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
1204414004290	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1204414004291	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
1204414004292	active site
1204414004293	putative homodimer interface [polypeptide binding]; other site
1204414004294	SAM binding site [chemical binding]; other site
1204414004295	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
1204414004296	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1204414004297	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1204414004298	classical (c) SDRs; Region: SDR_c; cd05233
1204414004299	NAD(P) binding site [chemical binding]; other site
1204414004300	active site
1204414004301	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1204414004302	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1204414004303	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1204414004304	active site
1204414004305	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1204414004306	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1204414004307	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
1204414004308	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1204414004309	ATP binding site [chemical binding]; other site
1204414004310	putative Mg++ binding site [ion binding]; other site
1204414004311	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1204414004312	nucleotide binding region [chemical binding]; other site
1204414004313	ATP-binding site [chemical binding]; other site
1204414004314	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
1204414004315	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
1204414004316	twin arginine translocase protein A; Provisional; Region: tatA; PRK00191
1204414004317	mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416
1204414004318	Predicted transcriptional regulator [Transcription]; Region: COG2378
1204414004319	WYL domain; Region: WYL; pfam13280
1204414004320	Predicted transcriptional regulator [Transcription]; Region: COG2378
1204414004321	WYL domain; Region: WYL; pfam13280
1204414004322	proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686
1204414004323	Pup-like protein; Region: Pup; pfam05639
1204414004324	proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688
1204414004325	proteasome ATPase; Region: pup_AAA; TIGR03689
1204414004326	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1204414004327	Walker A motif; other site
1204414004328	ATP binding site [chemical binding]; other site
1204414004329	Walker B motif; other site
1204414004330	arginine finger; other site
1204414004331	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
1204414004332	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1204414004333	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
1204414004334	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
1204414004335	active site
1204414004336	metal binding site [ion binding]; metal-binding site
1204414004337	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
1204414004338	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
1204414004339	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1204414004340	non-specific DNA binding site [nucleotide binding]; other site
1204414004341	salt bridge; other site
1204414004342	sequence-specific DNA binding site [nucleotide binding]; other site
1204414004343	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1204414004344	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414004345	putative substrate translocation pore; other site
1204414004346	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1204414004347	Aspartase; Region: Aspartase; cd01357
1204414004348	active sites [active]
1204414004349	tetramer interface [polypeptide binding]; other site
1204414004350	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
1204414004351	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
1204414004352	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
1204414004353	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
1204414004354	homodimer interface [polypeptide binding]; other site
1204414004355	putative metal binding site [ion binding]; other site
1204414004356	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1204414004357	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1204414004358	motif II; other site
1204414004359	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
1204414004360	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
1204414004361	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
1204414004362	substrate binding pocket [chemical binding]; other site
1204414004363	dimer interface [polypeptide binding]; other site
1204414004364	inhibitor binding site; inhibition site
1204414004365	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
1204414004366	B12 binding site [chemical binding]; other site
1204414004367	cobalt ligand [ion binding]; other site
1204414004368	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
1204414004369	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
1204414004370	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1204414004371	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
1204414004372	arsenical-resistance protein; Region: acr3; TIGR00832
1204414004373	Low molecular weight phosphatase family; Region: LMWPc; cl00105
1204414004374	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1204414004375	active site
1204414004376	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1204414004377	Low molecular weight phosphatase family; Region: LMWPc; cl00105
1204414004378	active site
1204414004379	cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447
1204414004380	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1204414004381	active site
1204414004382	HIGH motif; other site
1204414004383	nucleotide binding site [chemical binding]; other site
1204414004384	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1204414004385	active site
1204414004386	KMSKS motif; other site
1204414004387	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1204414004388	tRNA binding surface [nucleotide binding]; other site
1204414004389	anticodon binding site; other site
1204414004390	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
1204414004391	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1204414004392	active site
1204414004393	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1204414004394	catalytic tetrad [active]
1204414004395	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
1204414004396	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1204414004397	quinone interaction residues [chemical binding]; other site
1204414004398	active site
1204414004399	catalytic residues [active]
1204414004400	FMN binding site [chemical binding]; other site
1204414004401	substrate binding site [chemical binding]; other site
1204414004402	Integrase core domain; Region: rve; pfam00665
1204414004403	DDE domain; Region: DDE_Tnp_IS240; pfam13610
1204414004404	Integrase core domain; Region: rve_3; pfam13683
1204414004405	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1204414004406	substrate binding site [chemical binding]; other site
1204414004407	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1204414004408	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414004409	Walker A/P-loop; other site
1204414004410	ATP binding site [chemical binding]; other site
1204414004411	Q-loop/lid; other site
1204414004412	ABC transporter signature motif; other site
1204414004413	Walker B; other site
1204414004414	D-loop; other site
1204414004415	H-loop/switch region; other site
1204414004416	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
1204414004417	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1204414004418	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414004419	Q-loop/lid; other site
1204414004420	ABC transporter signature motif; other site
1204414004421	Walker B; other site
1204414004422	D-loop; other site
1204414004423	H-loop/switch region; other site
1204414004424	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1204414004425	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1204414004426	Coenzyme A binding pocket [chemical binding]; other site
1204414004427	membrane ATPase/protein kinase; Provisional; Region: PRK09435
1204414004428	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
1204414004429	Walker A; other site
1204414004430	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
1204414004431	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
1204414004432	active site
1204414004433	substrate binding site [chemical binding]; other site
1204414004434	coenzyme B12 binding site [chemical binding]; other site
1204414004435	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
1204414004436	B12 binding site [chemical binding]; other site
1204414004437	cobalt ligand [ion binding]; other site
1204414004438	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
1204414004439	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
1204414004440	heterodimer interface [polypeptide binding]; other site
1204414004441	substrate interaction site [chemical binding]; other site
1204414004442	Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Region: Sbm; COG2185
1204414004443	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1204414004444	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1204414004445	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1204414004446	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
1204414004447	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
1204414004448	Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
1204414004449	ferrochelatase; Reviewed; Region: hemH; PRK00035
1204414004450	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1204414004451	C-terminal domain interface [polypeptide binding]; other site
1204414004452	active site
1204414004453	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1204414004454	active site
1204414004455	N-terminal domain interface [polypeptide binding]; other site
1204414004456	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1204414004457	NlpC/P60 family; Region: NLPC_P60; pfam00877
1204414004458	aconitate hydratase; Validated; Region: PRK09277
1204414004459	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
1204414004460	substrate binding site [chemical binding]; other site
1204414004461	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
1204414004462	ligand binding site [chemical binding]; other site
1204414004463	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
1204414004464	substrate binding site [chemical binding]; other site
1204414004465	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1204414004466	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1204414004467	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
1204414004468	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
1204414004469	catalytic triad [active]
1204414004470	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1204414004471	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1204414004472	NAD(P) binding site [chemical binding]; other site
1204414004473	active site
1204414004474	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
1204414004475	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
1204414004476	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1204414004477	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
1204414004478	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1204414004479	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1204414004480	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1204414004481	motif II; other site
1204414004482	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1204414004483	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4762
1204414004484	The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910
1204414004485	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
1204414004486	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
1204414004487	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1204414004488	DNA binding site [nucleotide binding]
1204414004489	Int/Topo IB signature motif; other site
1204414004490	active site
1204414004491	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1204414004492	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1204414004493	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414004494	Walker A/P-loop; other site
1204414004495	ATP binding site [chemical binding]; other site
1204414004496	Q-loop/lid; other site
1204414004497	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1204414004498	ABC transporter signature motif; other site
1204414004499	Walker B; other site
1204414004500	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1204414004501	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
1204414004502	Arrestin (or S-antigen), C-terminal domain; Region: Arrestin_C; cl02844
1204414004503	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
1204414004504	catalytic site [active]
1204414004505	BNR repeat-like domain; Region: BNR_2; pfam13088
1204414004506	Asp-box motif; other site
1204414004507	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1204414004508	Integrase core domain; Region: rve; pfam00665
1204414004509	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1204414004510	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1204414004511	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1204414004512	trimerization site [polypeptide binding]; other site
1204414004513	active site
1204414004514	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1204414004515	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1204414004516	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1204414004517	catalytic residue [active]
1204414004518	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
1204414004519	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1204414004520	Walker A/P-loop; other site
1204414004521	ATP binding site [chemical binding]; other site
1204414004522	Q-loop/lid; other site
1204414004523	ABC transporter signature motif; other site
1204414004524	Walker B; other site
1204414004525	D-loop; other site
1204414004526	H-loop/switch region; other site
1204414004527	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
1204414004528	FeS assembly protein SufD; Region: sufD; TIGR01981
1204414004529	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1204414004530	FeS assembly protein SufB; Region: sufB; TIGR01980
1204414004531	Predicted transcriptional regulator [Transcription]; Region: COG2345
1204414004532	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1204414004533	putative DNA binding site [nucleotide binding]; other site
1204414004534	putative Zn2+ binding site [ion binding]; other site
1204414004535	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
1204414004536	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1204414004537	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1204414004538	Walker A/P-loop; other site
1204414004539	ATP binding site [chemical binding]; other site
1204414004540	Q-loop/lid; other site
1204414004541	ABC transporter signature motif; other site
1204414004542	Walker B; other site
1204414004543	D-loop; other site
1204414004544	H-loop/switch region; other site
1204414004545	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1204414004546	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1204414004547	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
1204414004548	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
1204414004549	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4951
1204414004550	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1204414004551	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1204414004552	ATP binding site [chemical binding]; other site
1204414004553	putative Mg++ binding site [ion binding]; other site
1204414004554	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1204414004555	nucleotide binding region [chemical binding]; other site
1204414004556	ATP-binding site [chemical binding]; other site
1204414004557	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1204414004558	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
1204414004559	NADP binding site [chemical binding]; other site
1204414004560	dimer interface [polypeptide binding]; other site
1204414004561	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
1204414004562	UbiA prenyltransferase family; Region: UbiA; pfam01040
1204414004563	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1204414004564	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1204414004565	TPP-binding site [chemical binding]; other site
1204414004566	dimer interface [polypeptide binding]; other site
1204414004567	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1204414004568	PYR/PP interface [polypeptide binding]; other site
1204414004569	dimer interface [polypeptide binding]; other site
1204414004570	TPP binding site [chemical binding]; other site
1204414004571	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
1204414004572	putative active site [active]
1204414004573	transaldolase; Provisional; Region: PRK03903
1204414004574	catalytic residue [active]
1204414004575	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1204414004576	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1204414004577	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1204414004578	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
1204414004579	Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429
1204414004580	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1204414004581	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
1204414004582	putative active site [active]
1204414004583	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1204414004584	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1204414004585	FAD dependent oxidoreductase; Region: DAO; pfam01266
1204414004586	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1204414004587	ornithine cyclodeaminase; Validated; Region: PRK06199
1204414004588	Ornithine cyclodeaminase/mu-crystallin family; Region: OCD_Mu_crystall; pfam02423
1204414004589	ammonium transporter; Region: amt; TIGR00836
1204414004590	Preprotein translocase SecG subunit; Region: SecG; cl09123
1204414004591	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
1204414004592	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
1204414004593	triosephosphate isomerase; Provisional; Region: PRK14567
1204414004594	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1204414004595	substrate binding site [chemical binding]; other site
1204414004596	dimer interface [polypeptide binding]; other site
1204414004597	catalytic triad [active]
1204414004598	Phosphoglycerate kinase; Region: PGK; pfam00162
1204414004599	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1204414004600	substrate binding site [chemical binding]; other site
1204414004601	hinge regions; other site
1204414004602	ADP binding site [chemical binding]; other site
1204414004603	catalytic site [active]
1204414004604	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1204414004605	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
1204414004606	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1204414004607	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
1204414004608	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
1204414004609	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
1204414004610	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
1204414004611	phosphate binding site [ion binding]; other site
1204414004612	putative substrate binding pocket [chemical binding]; other site
1204414004613	dimer interface [polypeptide binding]; other site
1204414004614	Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660
1204414004615	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1204414004616	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1204414004617	GIY-YIG motif/motif A; other site
1204414004618	active site
1204414004619	catalytic site [active]
1204414004620	putative DNA binding site [nucleotide binding]; other site
1204414004621	metal binding site [ion binding]; metal-binding site
1204414004622	UvrB/uvrC motif; Region: UVR; pfam02151
1204414004623	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1204414004624	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
1204414004625	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1204414004626	homopentamer interface [polypeptide binding]; other site
1204414004627	active site
1204414004628	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
1204414004629	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1204414004630	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1204414004631	dimerization interface [polypeptide binding]; other site
1204414004632	active site
1204414004633	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1204414004634	Lumazine binding domain; Region: Lum_binding; pfam00677
1204414004635	Lumazine binding domain; Region: Lum_binding; pfam00677
1204414004636	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
1204414004637	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1204414004638	catalytic motif [active]
1204414004639	Zn binding site [ion binding]; other site
1204414004640	RibD C-terminal domain; Region: RibD_C; pfam01872
1204414004641	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1204414004642	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1204414004643	substrate binding site [chemical binding]; other site
1204414004644	hexamer interface [polypeptide binding]; other site
1204414004645	metal binding site [ion binding]; metal-binding site
1204414004646	16S rRNA methyltransferase B; Provisional; Region: PRK14902
1204414004647	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
1204414004648	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1204414004649	S-adenosylmethionine binding site [chemical binding]; other site
1204414004650	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1204414004651	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1204414004652	putative active site [active]
1204414004653	substrate binding site [chemical binding]; other site
1204414004654	putative cosubstrate binding site; other site
1204414004655	catalytic site [active]
1204414004656	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1204414004657	substrate binding site [chemical binding]; other site
1204414004658	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1204414004659	active site
1204414004660	catalytic residues [active]
1204414004661	metal binding site [ion binding]; metal-binding site
1204414004662	primosome assembly protein PriA; Provisional; Region: PRK14873
1204414004663	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1204414004664	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1204414004665	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1204414004666	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1204414004667	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1204414004668	Flavoprotein; Region: Flavoprotein; pfam02441
1204414004669	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1204414004670	DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758
1204414004671	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1204414004672	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1204414004673	catalytic site [active]
1204414004674	G-X2-G-X-G-K; other site
1204414004675	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1204414004676	active site
1204414004677	dimer interface [polypeptide binding]; other site
1204414004678	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1204414004679	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1204414004680	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1204414004681	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1204414004682	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1204414004683	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1204414004684	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1204414004685	IMP binding site; other site
1204414004686	dimer interface [polypeptide binding]; other site
1204414004687	partial ornithine binding site; other site
1204414004688	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1204414004689	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1204414004690	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1204414004691	catalytic site [active]
1204414004692	subunit interface [polypeptide binding]; other site
1204414004693	dihydroorotase; Validated; Region: pyrC; PRK09357
1204414004694	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1204414004695	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1204414004696	active site
1204414004697	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1204414004698	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1204414004699	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1204414004700	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1204414004701	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1204414004702	active site
1204414004703	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1204414004704	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
1204414004705	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
1204414004706	putative NAD(P) binding site [chemical binding]; other site
1204414004707	putative active site [active]
1204414004708	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
1204414004709	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
1204414004710	Transcription termination factor [Transcription]; Region: NusB; COG0781
1204414004711	putative RNA binding site [nucleotide binding]; other site
1204414004712	elongation factor P; Validated; Region: PRK00529
1204414004713	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1204414004714	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1204414004715	RNA binding site [nucleotide binding]; other site
1204414004716	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1204414004717	RNA binding site [nucleotide binding]; other site
1204414004718	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1204414004719	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1204414004720	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1204414004721	active site
1204414004722	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1204414004723	active site
1204414004724	dimer interface [polypeptide binding]; other site
1204414004725	metal binding site [ion binding]; metal-binding site
1204414004726	shikimate kinase; Reviewed; Region: aroK; PRK00131
1204414004727	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1204414004728	ADP binding site [chemical binding]; other site
1204414004729	magnesium binding site [ion binding]; other site
1204414004730	putative shikimate binding site; other site
1204414004731	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1204414004732	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1204414004733	Tetramer interface [polypeptide binding]; other site
1204414004734	active site
1204414004735	FMN-binding site [chemical binding]; other site
1204414004736	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
1204414004737	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
1204414004738	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1204414004739	dimerization interface [polypeptide binding]; other site
1204414004740	putative DNA binding site [nucleotide binding]; other site
1204414004741	putative Zn2+ binding site [ion binding]; other site
1204414004742	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1204414004743	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1204414004744	ABC-ATPase subunit  interface; other site
1204414004745	dimer interface [polypeptide binding]; other site
1204414004746	putative PBP binding regions; other site
1204414004747	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1204414004748	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
1204414004749	putative ligand binding residues [chemical binding]; other site
1204414004750	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1204414004751	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1204414004752	Walker A/P-loop; other site
1204414004753	ATP binding site [chemical binding]; other site
1204414004754	Q-loop/lid; other site
1204414004755	ABC transporter signature motif; other site
1204414004756	Walker B; other site
1204414004757	D-loop; other site
1204414004758	H-loop/switch region; other site
1204414004759	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1204414004760	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1204414004761	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1204414004762	shikimate binding site; other site
1204414004763	NAD(P) binding site [chemical binding]; other site
1204414004764	YceG-like family; Region: YceG; pfam02618
1204414004765	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1204414004766	dimerization interface [polypeptide binding]; other site
1204414004767	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1204414004768	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1204414004769	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1204414004770	motif 1; other site
1204414004771	active site
1204414004772	motif 2; other site
1204414004773	motif 3; other site
1204414004774	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1204414004775	recombination factor protein RarA; Reviewed; Region: PRK13342
1204414004776	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1204414004777	Walker A motif; other site
1204414004778	ATP binding site [chemical binding]; other site
1204414004779	Walker B motif; other site
1204414004780	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1204414004781	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1204414004782	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1204414004783	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1204414004784	dimer interface [polypeptide binding]; other site
1204414004785	anticodon binding site; other site
1204414004786	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1204414004787	homodimer interface [polypeptide binding]; other site
1204414004788	motif 1; other site
1204414004789	active site
1204414004790	motif 2; other site
1204414004791	GAD domain; Region: GAD; pfam02938
1204414004792	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1204414004793	active site
1204414004794	motif 3; other site
1204414004795	Predicted metalloprotease [General function prediction only]; Region: COG2321
1204414004796	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
1204414004797	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1204414004798	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1204414004799	ATP binding site [chemical binding]; other site
1204414004800	putative Mg++ binding site [ion binding]; other site
1204414004801	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1204414004802	nucleotide binding region [chemical binding]; other site
1204414004803	ATP-binding site [chemical binding]; other site
1204414004804	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1204414004805	Predicted membrane protein [Function unknown]; Region: COG1511
1204414004806	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
1204414004807	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
1204414004808	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1204414004809	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414004810	Q-loop/lid; other site
1204414004811	ABC transporter signature motif; other site
1204414004812	Walker B; other site
1204414004813	D-loop; other site
1204414004814	H-loop/switch region; other site
1204414004815	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1204414004816	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1204414004817	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
1204414004818	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1204414004819	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1204414004820	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1204414004821	LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037
1204414004822	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1204414004823	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
1204414004824	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1204414004825	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1204414004826	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1204414004827	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1204414004828	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1204414004829	dimer interface [polypeptide binding]; other site
1204414004830	motif 1; other site
1204414004831	active site
1204414004832	motif 2; other site
1204414004833	motif 3; other site
1204414004834	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1204414004835	anticodon binding site; other site
1204414004836	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1204414004837	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1204414004838	active site
1204414004839	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1204414004840	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1204414004841	Zn2+ binding site [ion binding]; other site
1204414004842	Mg2+ binding site [ion binding]; other site
1204414004843	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1204414004844	synthetase active site [active]
1204414004845	NTP binding site [chemical binding]; other site
1204414004846	metal binding site [ion binding]; metal-binding site
1204414004847	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1204414004848	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1204414004849	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1204414004850	active site
1204414004851	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1204414004852	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1204414004853	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
1204414004854	Protein export membrane protein; Region: SecD_SecF; cl14618
1204414004855	Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342
1204414004856	Protein export membrane protein; Region: SecD_SecF; cl14618
1204414004857	Preprotein translocase subunit; Region: YajC; pfam02699
1204414004858	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1204414004859	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1204414004860	Walker A motif; other site
1204414004861	ATP binding site [chemical binding]; other site
1204414004862	Walker B motif; other site
1204414004863	arginine finger; other site
1204414004864	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1204414004865	Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632
1204414004866	RuvA N terminal domain; Region: RuvA_N; pfam01330
1204414004867	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1204414004868	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
1204414004869	active site
1204414004870	putative DNA-binding cleft [nucleotide binding]; other site
1204414004871	dimer interface [polypeptide binding]; other site
1204414004872	hypothetical protein; Validated; Region: PRK00110
1204414004873	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
1204414004874	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
1204414004875	active site
1204414004876	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
1204414004877	catalytic triad [active]
1204414004878	dimer interface [polypeptide binding]; other site
1204414004879	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
1204414004880	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1204414004881	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1204414004882	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1204414004883	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
1204414004884	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1204414004885	putative acyl-acceptor binding pocket; other site
1204414004886	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
1204414004887	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
1204414004888	nucleotide binding site/active site [active]
1204414004889	HIT family signature motif; other site
1204414004890	catalytic residue [active]
1204414004891	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
1204414004892	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
1204414004893	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1204414004894	active site
1204414004895	dimer interface [polypeptide binding]; other site
1204414004896	motif 1; other site
1204414004897	motif 2; other site
1204414004898	motif 3; other site
1204414004899	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1204414004900	anticodon binding site; other site
1204414004901	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
1204414004902	Copper(I)-binding protein [Inorganic ion transport and    metabolism]; Region: COG2847
1204414004903	Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372
1204414004904	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1204414004905	nucleotide binding site [chemical binding]; other site
1204414004906	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
1204414004907	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1204414004908	Coenzyme A binding pocket [chemical binding]; other site
1204414004909	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
1204414004910	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414004911	Walker A/P-loop; other site
1204414004912	ATP binding site [chemical binding]; other site
1204414004913	ABC transporter signature motif; other site
1204414004914	Walker B; other site
1204414004915	D-loop; other site
1204414004916	H-loop/switch region; other site
1204414004917	Phosphotransferase enzyme family; Region: APH; pfam01636
1204414004918	Flavoprotein; Region: Flavoprotein; cl08021
1204414004919	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236
1204414004920	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
1204414004921	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
1204414004922	multiple promoter invertase; Provisional; Region: mpi; PRK13413
1204414004923	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1204414004924	catalytic residues [active]
1204414004925	catalytic nucleophile [active]
1204414004926	Presynaptic Site I dimer interface [polypeptide binding]; other site
1204414004927	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1204414004928	Synaptic Flat tetramer interface [polypeptide binding]; other site
1204414004929	Synaptic Site I dimer interface [polypeptide binding]; other site
1204414004930	DNA binding site [nucleotide binding]
1204414004931	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1204414004932	DNA-binding interface [nucleotide binding]; DNA binding site
1204414004933	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1204414004934	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
1204414004935	Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453
1204414004936	active site
1204414004937	catalytic residues [active]
1204414004938	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1204414004939	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1204414004940	DNA-binding site [nucleotide binding]; DNA binding site
1204414004941	FCD domain; Region: FCD; pfam07729
1204414004942	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
1204414004943	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
1204414004944	putative transposase OrfB; Reviewed; Region: PHA02517
1204414004945	HTH-like domain; Region: HTH_21; pfam13276
1204414004946	Integrase core domain; Region: rve; pfam00665
1204414004947	Integrase core domain; Region: rve_3; pfam13683
1204414004948	Protein of unknown function (DUF2699); Region: DUF2699; pfam10919
1204414004949	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1204414004950	Transposase; Region: HTH_Tnp_1; pfam01527
1204414004951	Single-stranded DNA-specific exonuclease [DNA replication, recombination, and repair]; Region: RecJ; COG0608
1204414004952	DHH family; Region: DHH; pfam01368
1204414004953	Phage associated DNA primase [General function prediction only]; Region: COG3378
1204414004954	D5 N terminal like; Region: D5_N; smart00885
1204414004955	Poxvirus D5 protein-like; Region: Pox_D5; pfam03288
1204414004956	VRR-NUC domain; Region: VRR_NUC; pfam08774
1204414004957	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1204414004958	putative Mg++ binding site [ion binding]; other site
1204414004959	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
1204414004960	Domain of unknown function (DUF4406); Region: DUF4406; pfam14359
1204414004961	Lsr2; Region: Lsr2; pfam11774
1204414004962	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1204414004963	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1204414004964	MoxR-like ATPases [General function prediction only]; Region: COG0714
1204414004965	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1204414004966	Walker A motif; other site
1204414004967	ATP binding site [chemical binding]; other site
1204414004968	Walker B motif; other site
1204414004969	arginine finger; other site
1204414004970	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1204414004971	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1204414004972	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1204414004973	Walker A motif; other site
1204414004974	ATP binding site [chemical binding]; other site
1204414004975	Walker B motif; other site
1204414004976	arginine finger; other site
1204414004977	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1204414004978	Walker A motif; other site
1204414004979	ATP binding site [chemical binding]; other site
1204414004980	Walker B motif; other site
1204414004981	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1204414004982	Part of AAA domain; Region: AAA_19; pfam13245
1204414004983	Family description; Region: UvrD_C_2; pfam13538
1204414004984	Drosophila Retinin like protein; Region: Retinin_C; pfam04527
1204414004985	NUDIX domain; Region: NUDIX; pfam00293
1204414004986	nudix motif; other site
1204414004987	deoxynucleoside monophosphate kinase; Provisional; Region: 1; PHA02575
1204414004988	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208
1204414004989	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
1204414004990	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1204414004991	cofactor binding site; other site
1204414004992	DNA binding site [nucleotide binding]
1204414004993	substrate interaction site [chemical binding]; other site
1204414004994	Putative catalytic domain of type II restriction enzyme NgoFVII and similar proteins; Region: PLDc_RE_NgoFVII; cd09177
1204414004995	PLD-like domain; Region: PLDc_2; pfam13091
1204414004996	putative homodimer interface [polypeptide binding]; other site
1204414004997	putative active site [active]
1204414004998	catalytic site [active]
1204414004999	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1204414005000	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1204414005001	ATP binding site [chemical binding]; other site
1204414005002	putative Mg++ binding site [ion binding]; other site
1204414005003	Z1 domain; Region: Z1; pfam10593
1204414005004	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
1204414005005	Domain of unknown function (DUF4379); Region: DUF4379; pfam14311
1204414005006	Domain of unknown function (DUF4379); Region: DUF4379; pfam14311
1204414005007	Domain of unknown function (DUF4379); Region: DUF4379; pfam14311
1204414005008	Domain of unknown function (DUF4379); Region: DUF4379; pfam14311
1204414005009	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
1204414005010	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1204414005011	Walker A motif; other site
1204414005012	ATP binding site [chemical binding]; other site
1204414005013	Walker B motif; other site
1204414005014	arginine finger; other site
1204414005015	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1204414005016	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1204414005017	Walker A motif; other site
1204414005018	ATP binding site [chemical binding]; other site
1204414005019	Walker B motif; other site
1204414005020	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1204414005021	Protein of unknown function (DUF456); Region: DUF456; pfam04306
1204414005022	Hantavirus nucleocapsid protein; Region: Hanta_nucleocap; pfam00846
1204414005023	GIY-YIG catalytic domain; Region: GIY-YIG; pfam01541
1204414005024	GIY-YIG motif/motif A; other site
1204414005025	active site
1204414005026	catalytic site [active]
1204414005027	metal binding site [ion binding]; metal-binding site
1204414005028	Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954
1204414005029	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
1204414005030	Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651
1204414005031	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1204414005032	non-specific DNA binding site [nucleotide binding]; other site
1204414005033	salt bridge; other site
1204414005034	sequence-specific DNA binding site [nucleotide binding]; other site
1204414005035	chromosomal replication initiation protein; Provisional; Region: PRK12422
1204414005036	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
1204414005037	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
1204414005038	active site
1204414005039	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
1204414005040	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
1204414005041	LGFP repeat; Region: LGFP; pfam08310
1204414005042	LGFP repeat; Region: LGFP; pfam08310
1204414005043	LGFP repeat; Region: LGFP; pfam08310
1204414005044	AAA-like domain; Region: AAA_10; pfam12846
1204414005045	Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550
1204414005046	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1204414005047	active site
1204414005048	putative interdomain interaction site [polypeptide binding]; other site
1204414005049	putative metal-binding site [ion binding]; other site
1204414005050	putative nucleotide binding site [chemical binding]; other site
1204414005051	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1204414005052	domain I; other site
1204414005053	DNA binding groove [nucleotide binding]
1204414005054	phosphate binding site [ion binding]; other site
1204414005055	domain II; other site
1204414005056	domain III; other site
1204414005057	nucleotide binding site [chemical binding]; other site
1204414005058	catalytic site [active]
1204414005059	domain IV; other site
1204414005060	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1204414005061	DEAD/DEAH box helicase; Region: DEAD; pfam00270
1204414005062	ATP binding site [chemical binding]; other site
1204414005063	putative Mg++ binding site [ion binding]; other site
1204414005064	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
1204414005065	Family description; Region: UvrD_C_2; pfam13538
1204414005066	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1204414005067	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1204414005068	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4815
1204414005069	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
1204414005070	LGFP repeat; Region: LGFP; pfam08310
1204414005071	LGFP repeat; Region: LGFP; pfam08310
1204414005072	LGFP repeat; Region: LGFP; pfam08310
1204414005073	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
1204414005074	Staphylococcal nuclease homologues; Region: SNc; smart00318
1204414005075	Catalytic site; other site
1204414005076	Staphylococcal nuclease homologue; Region: SNase; pfam00565
1204414005077	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1204414005078	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1204414005079	dimer interface [polypeptide binding]; other site
1204414005080	ssDNA binding site [nucleotide binding]; other site
1204414005081	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1204414005082	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
1204414005083	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
1204414005084	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1204414005085	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1204414005086	active site
1204414005087	catalytic residues [active]
1204414005088	DNA binding site [nucleotide binding]
1204414005089	Int/Topo IB signature motif; other site
1204414005090	Integrase core domain; Region: rve; pfam00665
1204414005091	HTH-like domain; Region: HTH_21; pfam13276
1204414005092	Integrase core domain; Region: rve; pfam00665
1204414005093	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1204414005094	Transposase; Region: HTH_Tnp_1; cl17663
1204414005095	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
1204414005096	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1204414005097	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1204414005098	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1204414005099	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1204414005100	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4815
1204414005101	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
1204414005102	LGFP repeat; Region: LGFP; pfam08310
1204414005103	LGFP repeat; Region: LGFP; pfam08310
1204414005104	LGFP repeat; Region: LGFP; pfam08310
1204414005105	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1204414005106	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1204414005107	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1204414005108	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
1204414005109	hypothetical protein; Provisional; Region: PRK14059
1204414005110	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
1204414005111	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
1204414005112	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
1204414005113	SelR domain; Region: SelR; pfam01641
1204414005114	Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253
1204414005115	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
1204414005116	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
1204414005117	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
1204414005118	catalytic site [active]
1204414005119	putative active site [active]
1204414005120	putative substrate binding site [chemical binding]; other site
1204414005121	HRDC domain; Region: HRDC; pfam00570
1204414005122	Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154
1204414005123	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1204414005124	TPP-binding site; other site
1204414005125	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1204414005126	PYR/PP interface [polypeptide binding]; other site
1204414005127	dimer interface [polypeptide binding]; other site
1204414005128	TPP binding site [chemical binding]; other site
1204414005129	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1204414005130	TRAM domain; Region: TRAM; pfam01938
1204414005131	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1204414005132	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
1204414005133	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1204414005134	trimer interface [polypeptide binding]; other site
1204414005135	active site
1204414005136	Protein of unknown function (DUF3093); Region: DUF3093; pfam11292
1204414005137	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
1204414005138	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1204414005139	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
1204414005140	active site
1204414005141	dimerization interface [polypeptide binding]; other site
1204414005142	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1204414005143	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1204414005144	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
1204414005145	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1204414005146	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1204414005147	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1204414005148	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1204414005149	DNA binding residues [nucleotide binding]
1204414005150	Predicted membrane protein [Function unknown]; Region: COG2311
1204414005151	Protein of unknown function (DUF418); Region: DUF418; cl12135
1204414005152	Protein of unknown function (DUF418); Region: DUF418; pfam04235
1204414005153	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1204414005154	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1204414005155	ATP binding site [chemical binding]; other site
1204414005156	putative Mg++ binding site [ion binding]; other site
1204414005157	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
1204414005158	Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
1204414005159	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
1204414005160	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1204414005161	S-adenosylmethionine binding site [chemical binding]; other site
1204414005162	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1204414005163	putative active site [active]
1204414005164	dimerization interface [polypeptide binding]; other site
1204414005165	putative tRNAtyr binding site [nucleotide binding]; other site
1204414005166	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
1204414005167	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1204414005168	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1204414005169	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1204414005170	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1204414005171	DNA binding residues [nucleotide binding]
1204414005172	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1204414005173	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
1204414005174	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1204414005175	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
1204414005176	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1204414005177	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1204414005178	NAD binding site [chemical binding]; other site
1204414005179	homodimer interface [polypeptide binding]; other site
1204414005180	active site
1204414005181	substrate binding site [chemical binding]; other site
1204414005182	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
1204414005183	PAC2 family; Region: PAC2; pfam09754
1204414005184	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1204414005185	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1204414005186	ATP binding site [chemical binding]; other site
1204414005187	putative Mg++ binding site [ion binding]; other site
1204414005188	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1204414005189	nucleotide binding region [chemical binding]; other site
1204414005190	ATP-binding site [chemical binding]; other site
1204414005191	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
1204414005192	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1204414005193	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
1204414005194	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
1204414005195	dimerization interface [polypeptide binding]; other site
1204414005196	Predicted integral membrane protein [Function unknown]; Region: COG5473
1204414005197	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
1204414005198	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1204414005199	ATP binding site [chemical binding]; other site
1204414005200	putative Mg++ binding site [ion binding]; other site
1204414005201	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1204414005202	nucleotide binding region [chemical binding]; other site
1204414005203	ATP-binding site [chemical binding]; other site
1204414005204	Helicase associated domain (HA2); Region: HA2; pfam04408
1204414005205	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
1204414005206	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
1204414005207	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1204414005208	ATP cone domain; Region: ATP-cone; pfam03477
1204414005209	LexA repressor; Validated; Region: PRK00215
1204414005210	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
1204414005211	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1204414005212	Catalytic site [active]
1204414005213	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1204414005214	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1204414005215	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1204414005216	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1204414005217	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1204414005218	substrate binding site [chemical binding]; other site
1204414005219	ATP binding site [chemical binding]; other site
1204414005220	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1204414005221	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1204414005222	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1204414005223	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1204414005224	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1204414005225	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1204414005226	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1204414005227	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1204414005228	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1204414005229	putative substrate binding site [chemical binding]; other site
1204414005230	putative ATP binding site [chemical binding]; other site
1204414005231	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
1204414005232	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1204414005233	active site
1204414005234	phosphorylation site [posttranslational modification]
1204414005235	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1204414005236	active site
1204414005237	P-loop; other site
1204414005238	phosphorylation site [posttranslational modification]
1204414005239	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1204414005240	Phosphotransferase System HPr (HPr) Family; Region: PTS_HPr_family; TIGR01003
1204414005241	dimerization domain swap beta strand [polypeptide binding]; other site
1204414005242	regulatory protein interface [polypeptide binding]; other site
1204414005243	active site
1204414005244	regulatory phosphorylation site [posttranslational modification]; other site
1204414005245	Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978
1204414005246	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
1204414005247	GTPases [General function prediction only]; Region: HflX; COG2262
1204414005248	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1204414005249	HflX GTPase family; Region: HflX; cd01878
1204414005250	G1 box; other site
1204414005251	GTP/Mg2+ binding site [chemical binding]; other site
1204414005252	Switch I region; other site
1204414005253	G2 box; other site
1204414005254	G3 box; other site
1204414005255	Switch II region; other site
1204414005256	G4 box; other site
1204414005257	G5 box; other site
1204414005258	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1204414005259	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1204414005260	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1204414005261	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1204414005262	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1204414005263	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
1204414005264	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
1204414005265	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
1204414005266	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1204414005267	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1204414005268	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
1204414005269	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1204414005270	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1204414005271	FeS/SAM binding site; other site
1204414005272	TRAM domain; Region: TRAM; cl01282
1204414005273	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1204414005274	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1204414005275	Walker A/P-loop; other site
1204414005276	ATP binding site [chemical binding]; other site
1204414005277	Q-loop/lid; other site
1204414005278	ABC transporter signature motif; other site
1204414005279	Walker B; other site
1204414005280	D-loop; other site
1204414005281	H-loop/switch region; other site
1204414005282	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
1204414005283	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1204414005284	substrate binding pocket [chemical binding]; other site
1204414005285	membrane-bound complex binding site; other site
1204414005286	hinge residues; other site
1204414005287	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1204414005288	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1204414005289	dimer interface [polypeptide binding]; other site
1204414005290	conserved gate region; other site
1204414005291	putative PBP binding loops; other site
1204414005292	ABC-ATPase subunit interface; other site
1204414005293	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1204414005294	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1204414005295	dimer interface [polypeptide binding]; other site
1204414005296	conserved gate region; other site
1204414005297	putative PBP binding loops; other site
1204414005298	ABC-ATPase subunit interface; other site
1204414005299	Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137
1204414005300	recombinase A; Provisional; Region: recA; PRK09354
1204414005301	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1204414005302	hexamer interface [polypeptide binding]; other site
1204414005303	Walker A motif; other site
1204414005304	ATP binding site [chemical binding]; other site
1204414005305	Walker B motif; other site
1204414005306	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
1204414005307	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
1204414005308	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1204414005309	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1204414005310	Walker A/P-loop; other site
1204414005311	ATP binding site [chemical binding]; other site
1204414005312	Q-loop/lid; other site
1204414005313	ABC transporter signature motif; other site
1204414005314	Walker B; other site
1204414005315	D-loop; other site
1204414005316	H-loop/switch region; other site
1204414005317	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1204414005318	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
1204414005319	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1204414005320	non-specific DNA binding site [nucleotide binding]; other site
1204414005321	salt bridge; other site
1204414005322	sequence-specific DNA binding site [nucleotide binding]; other site
1204414005323	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
1204414005324	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
1204414005325	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350
1204414005326	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
1204414005327	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
1204414005328	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1204414005329	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1204414005330	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1204414005331	TIGR03085 family protein; Region: TIGR03085
1204414005332	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
1204414005333	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1204414005334	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1204414005335	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1204414005336	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1204414005337	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1204414005338	dimer interface [polypeptide binding]; other site
1204414005339	active site
1204414005340	catalytic residue [active]
1204414005341	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
1204414005342	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1204414005343	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1204414005344	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1204414005345	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
1204414005346	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
1204414005347	oligomer interface [polypeptide binding]; other site
1204414005348	RNA binding site [nucleotide binding]; other site
1204414005349	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1204414005350	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1204414005351	RNase E interface [polypeptide binding]; other site
1204414005352	trimer interface [polypeptide binding]; other site
1204414005353	active site
1204414005354	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1204414005355	putative nucleic acid binding region [nucleotide binding]; other site
1204414005356	G-X-X-G motif; other site
1204414005357	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1204414005358	RNA binding site [nucleotide binding]; other site
1204414005359	domain interface; other site
1204414005360	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1204414005361	16S/18S rRNA binding site [nucleotide binding]; other site
1204414005362	S13e-L30e interaction site [polypeptide binding]; other site
1204414005363	25S rRNA binding site [nucleotide binding]; other site
1204414005364	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
1204414005365	active site
1204414005366	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1204414005367	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1204414005368	active site
1204414005369	Riboflavin kinase; Region: Flavokinase; smart00904
1204414005370	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
1204414005371	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1204414005372	RNA binding site [nucleotide binding]; other site
1204414005373	active site
1204414005374	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
1204414005375	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
1204414005376	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1204414005377	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
1204414005378	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1204414005379	active site
1204414005380	metal binding site [ion binding]; metal-binding site
1204414005381	putative phosphoesterase; Region: acc_ester; TIGR03729
1204414005382	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1204414005383	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
1204414005384	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1204414005385	DHH family; Region: DHH; pfam01368
1204414005386	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1204414005387	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1204414005388	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1204414005389	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
1204414005390	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1204414005391	G1 box; other site
1204414005392	putative GEF interaction site [polypeptide binding]; other site
1204414005393	GTP/Mg2+ binding site [chemical binding]; other site
1204414005394	Switch I region; other site
1204414005395	G2 box; other site
1204414005396	G3 box; other site
1204414005397	Switch II region; other site
1204414005398	G4 box; other site
1204414005399	G5 box; other site
1204414005400	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1204414005401	Translation-initiation factor 2; Region: IF-2; pfam11987
1204414005402	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1204414005403	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
1204414005404	putative RNA binding cleft [nucleotide binding]; other site
1204414005405	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
1204414005406	NusA N-terminal domain; Region: NusA_N; pfam08529
1204414005407	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1204414005408	RNA binding site [nucleotide binding]; other site
1204414005409	homodimer interface [polypeptide binding]; other site
1204414005410	NusA-like KH domain; Region: KH_5; pfam13184
1204414005411	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1204414005412	G-X-X-G motif; other site
1204414005413	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1204414005414	Sm and related proteins; Region: Sm_like; cl00259
1204414005415	Sm and related proteins; Region: Sm_like; cl00259
1204414005416	heptamer interface [polypeptide binding]; other site
1204414005417	Sm1 motif; other site
1204414005418	hexamer interface [polypeptide binding]; other site
1204414005419	RNA binding site [nucleotide binding]; other site
1204414005420	Sm2 motif; other site
1204414005421	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1204414005422	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
1204414005423	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1204414005424	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1204414005425	dimer interface [polypeptide binding]; other site
1204414005426	conserved gate region; other site
1204414005427	ABC-ATPase subunit interface; other site
1204414005428	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1204414005429	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1204414005430	dimer interface [polypeptide binding]; other site
1204414005431	conserved gate region; other site
1204414005432	putative PBP binding loops; other site
1204414005433	ABC-ATPase subunit interface; other site
1204414005434	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1204414005435	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1204414005436	Walker A/P-loop; other site
1204414005437	ATP binding site [chemical binding]; other site
1204414005438	Q-loop/lid; other site
1204414005439	ABC transporter signature motif; other site
1204414005440	Walker B; other site
1204414005441	D-loop; other site
1204414005442	H-loop/switch region; other site
1204414005443	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1204414005444	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1204414005445	Walker A/P-loop; other site
1204414005446	ATP binding site [chemical binding]; other site
1204414005447	Q-loop/lid; other site
1204414005448	ABC transporter signature motif; other site
1204414005449	Walker B; other site
1204414005450	D-loop; other site
1204414005451	H-loop/switch region; other site
1204414005452	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1204414005453	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1204414005454	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1204414005455	dimer interface [polypeptide binding]; other site
1204414005456	motif 1; other site
1204414005457	active site
1204414005458	motif 2; other site
1204414005459	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1204414005460	putative deacylase active site [active]
1204414005461	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1204414005462	active site
1204414005463	motif 3; other site
1204414005464	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1204414005465	anticodon binding site; other site
1204414005466	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3022
1204414005467	Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240
1204414005468	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
1204414005469	metal ion-dependent adhesion site (MIDAS); other site
1204414005470	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
1204414005471	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1204414005472	Walker A motif; other site
1204414005473	ATP binding site [chemical binding]; other site
1204414005474	Walker B motif; other site
1204414005475	arginine finger; other site
1204414005476	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1204414005477	diphthine synthase; Region: dph5; TIGR00522
1204414005478	active site
1204414005479	SAM binding site [chemical binding]; other site
1204414005480	homodimer interface [polypeptide binding]; other site
1204414005481	Uncharacterized conserved protein [Function unknown]; Region: COG0397
1204414005482	hypothetical protein; Validated; Region: PRK00029
1204414005483	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1204414005484	dimer interface [polypeptide binding]; other site
1204414005485	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1204414005486	dimer interface [polypeptide binding]; other site
1204414005487	malate:quinone oxidoreductase; Validated; Region: PRK05257
1204414005488	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
1204414005489	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1204414005490	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1204414005491	mycothione reductase; Region: mycothione_red; TIGR03452
1204414005492	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1204414005493	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1204414005494	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1204414005495	active site
1204414005496	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
1204414005497	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1204414005498	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1204414005499	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1204414005500	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1204414005501	active site
1204414005502	phosphorylation site [posttranslational modification]
1204414005503	intermolecular recognition site; other site
1204414005504	dimerization interface [polypeptide binding]; other site
1204414005505	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1204414005506	DNA binding residues [nucleotide binding]
1204414005507	dimerization interface [polypeptide binding]; other site
1204414005508	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1204414005509	Histidine kinase; Region: HisKA_3; pfam07730
1204414005510	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1204414005511	Mg2+ binding site [ion binding]; other site
1204414005512	G-X-G motif; other site
1204414005513	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1204414005514	FtsX-like permease family; Region: FtsX; pfam02687
1204414005515	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1204414005516	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1204414005517	Walker A/P-loop; other site
1204414005518	ATP binding site [chemical binding]; other site
1204414005519	Q-loop/lid; other site
1204414005520	ABC transporter signature motif; other site
1204414005521	Walker B; other site
1204414005522	D-loop; other site
1204414005523	H-loop/switch region; other site
1204414005524	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1204414005525	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1204414005526	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1204414005527	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
1204414005528	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1204414005529	active site
1204414005530	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1204414005531	protein binding site [polypeptide binding]; other site
1204414005532	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1204414005533	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1204414005534	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1204414005535	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1204414005536	Protein of unknown function (DUF2631); Region: DUF2631; pfam10939
1204414005537	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1204414005538	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1204414005539	Walker A/P-loop; other site
1204414005540	ATP binding site [chemical binding]; other site
1204414005541	Q-loop/lid; other site
1204414005542	ABC transporter signature motif; other site
1204414005543	Walker B; other site
1204414005544	D-loop; other site
1204414005545	H-loop/switch region; other site
1204414005546	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459
1204414005547	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1204414005548	FeS/SAM binding site; other site
1204414005549	Uncharacterized integral membrane protein [Function unknown]; Region: COG5416
1204414005550	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1204414005551	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1204414005552	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1204414005553	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1204414005554	hinge region; other site
1204414005555	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1204414005556	putative nucleotide binding site [chemical binding]; other site
1204414005557	uridine monophosphate binding site [chemical binding]; other site
1204414005558	homohexameric interface [polypeptide binding]; other site
1204414005559	elongation factor Ts; Provisional; Region: tsf; PRK09377
1204414005560	UBA/TS-N domain; Region: UBA; pfam00627
1204414005561	Elongation factor TS; Region: EF_TS; pfam00889
1204414005562	Elongation factor TS; Region: EF_TS; pfam00889
1204414005563	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1204414005564	rRNA interaction site [nucleotide binding]; other site
1204414005565	S8 interaction site; other site
1204414005566	putative laminin-1 binding site; other site
1204414005567	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1204414005568	Peptidase family M23; Region: Peptidase_M23; pfam01551
1204414005569	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
1204414005570	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1204414005571	active site
1204414005572	DNA binding site [nucleotide binding]
1204414005573	Int/Topo IB signature motif; other site
1204414005574	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
1204414005575	DNA protecting protein DprA; Region: dprA; TIGR00732
1204414005576	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
1204414005577	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1204414005578	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
1204414005579	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
1204414005580	hypothetical protein; Reviewed; Region: PRK12497
1204414005581	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
1204414005582	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1204414005583	RNA/DNA hybrid binding site [nucleotide binding]; other site
1204414005584	active site
1204414005585	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1204414005586	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1204414005587	Catalytic site [active]
1204414005588	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1204414005589	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1204414005590	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1204414005591	siderophore binding site; other site
1204414005592	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1204414005593	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1204414005594	active site
1204414005595	pyrophosphate binding site [ion binding]; other site
1204414005596	thiamine phosphate binding site [chemical binding]; other site
1204414005597	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
1204414005598	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
1204414005599	thiS-thiF/thiG interaction site; other site
1204414005600	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
1204414005601	ThiS interaction site; other site
1204414005602	putative active site [active]
1204414005603	tetramer interface [polypeptide binding]; other site
1204414005604	thiamine biosynthesis protein ThiF; Validated; Region: PRK05600
1204414005605	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1204414005606	ATP binding site [chemical binding]; other site
1204414005607	substrate interface [chemical binding]; other site
1204414005608	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: PspE; COG0607
1204414005609	active site residue [active]
1204414005610	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1204414005611	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1204414005612	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1204414005613	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1204414005614	RNA binding site [nucleotide binding]; other site
1204414005615	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1204414005616	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1204414005617	DNA binding site [nucleotide binding]
1204414005618	domain linker motif; other site
1204414005619	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1204414005620	dimerization interface [polypeptide binding]; other site
1204414005621	ligand binding site [chemical binding]; other site
1204414005622	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1204414005623	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
1204414005624	transmembrane helices; other site
1204414005625	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
1204414005626	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
1204414005627	tetramer interface [polypeptide binding]; other site
1204414005628	active site
1204414005629	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1204414005630	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1204414005631	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1204414005632	Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
1204414005633	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1204414005634	RimM N-terminal domain; Region: RimM; pfam01782
1204414005635	PRC-barrel domain; Region: PRC; pfam05239
1204414005636	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1204414005637	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
1204414005638	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1204414005639	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1204414005640	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1204414005641	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1204414005642	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414005643	Walker A/P-loop; other site
1204414005644	ATP binding site [chemical binding]; other site
1204414005645	Q-loop/lid; other site
1204414005646	ABC transporter signature motif; other site
1204414005647	Walker B; other site
1204414005648	D-loop; other site
1204414005649	H-loop/switch region; other site
1204414005650	signal recognition particle protein; Provisional; Region: PRK10867
1204414005651	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1204414005652	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1204414005653	P loop; other site
1204414005654	GTP binding site [chemical binding]; other site
1204414005655	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1204414005656	PII uridylyl-transferase; Provisional; Region: glnD; PRK00227
1204414005657	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1204414005658	metal binding triad; other site
1204414005659	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1204414005660	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1204414005661	Zn2+ binding site [ion binding]; other site
1204414005662	Mg2+ binding site [ion binding]; other site
1204414005663	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
1204414005664	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1204414005665	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1204414005666	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1204414005667	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1204414005668	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1204414005669	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
1204414005670	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1204414005671	Walker A/P-loop; other site
1204414005672	ATP binding site [chemical binding]; other site
1204414005673	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470
1204414005674	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1204414005675	ABC transporter signature motif; other site
1204414005676	Walker B; other site
1204414005677	D-loop; other site
1204414005678	H-loop/switch region; other site
1204414005679	acylphosphatase; Provisional; Region: PRK14422
1204414005680	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
1204414005681	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1204414005682	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1204414005683	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1204414005684	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1204414005685	dimerization interface [polypeptide binding]; other site
1204414005686	hypothetical protein; Provisional; Region: PRK10621
1204414005687	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1204414005688	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4815
1204414005689	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1204414005690	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1204414005691	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1204414005692	DNA binding site [nucleotide binding]
1204414005693	catalytic residue [active]
1204414005694	H2TH interface [polypeptide binding]; other site
1204414005695	putative catalytic residues [active]
1204414005696	turnover-facilitating residue; other site
1204414005697	intercalation triad [nucleotide binding]; other site
1204414005698	8OG recognition residue [nucleotide binding]; other site
1204414005699	putative reading head residues; other site
1204414005700	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1204414005701	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1204414005702	ribonuclease III; Reviewed; Region: rnc; PRK00102
1204414005703	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1204414005704	dimerization interface [polypeptide binding]; other site
1204414005705	active site
1204414005706	metal binding site [ion binding]; metal-binding site
1204414005707	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1204414005708	dsRNA binding site [nucleotide binding]; other site
1204414005709	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
1204414005710	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
1204414005711	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
1204414005712	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1204414005713	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1204414005714	Walker A/P-loop; other site
1204414005715	ATP binding site [chemical binding]; other site
1204414005716	Q-loop/lid; other site
1204414005717	ABC transporter signature motif; other site
1204414005718	Walker B; other site
1204414005719	D-loop; other site
1204414005720	H-loop/switch region; other site
1204414005721	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1204414005722	Walker A/P-loop; other site
1204414005723	ATP binding site [chemical binding]; other site
1204414005724	ABC transporter; Region: ABC_tran; pfam00005
1204414005725	Q-loop/lid; other site
1204414005726	ABC transporter signature motif; other site
1204414005727	Walker B; other site
1204414005728	D-loop; other site
1204414005729	H-loop/switch region; other site
1204414005730	glutamate dehydrogenase; Provisional; Region: PRK09414
1204414005731	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1204414005732	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
1204414005733	NAD(P) binding site [chemical binding]; other site
1204414005734	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
1204414005735	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
1204414005736	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
1204414005737	nucleotide binding site/active site [active]
1204414005738	HIT family signature motif; other site
1204414005739	catalytic residue [active]
1204414005740	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1204414005741	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
1204414005742	metal binding site [ion binding]; metal-binding site
1204414005743	putative dimer interface [polypeptide binding]; other site
1204414005744	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
1204414005745	putative homodimer interface [polypeptide binding]; other site
1204414005746	putative active site pocket [active]
1204414005747	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
1204414005748	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
1204414005749	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
1204414005750	putative metal binding site [ion binding]; other site
1204414005751	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1204414005752	active site
1204414005753	pyruvate kinase; Provisional; Region: PRK06247
1204414005754	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1204414005755	domain interfaces; other site
1204414005756	active site
1204414005757	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
1204414005758	Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Region: TrpC; COG0134
1204414005759	phosphate binding site [ion binding]; other site
1204414005760	Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534
1204414005761	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
1204414005762	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1204414005763	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1204414005764	substrate binding site [chemical binding]; other site
1204414005765	glutamase interaction surface [polypeptide binding]; other site
1204414005766	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
1204414005767	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1204414005768	active site
1204414005769	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1204414005770	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1204414005771	catalytic residues [active]
1204414005772	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
1204414005773	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1204414005774	putative active site [active]
1204414005775	oxyanion strand; other site
1204414005776	catalytic triad [active]
1204414005777	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414005778	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1204414005779	putative substrate translocation pore; other site
1204414005780	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1204414005781	putative active site pocket [active]
1204414005782	4-fold oligomerization interface [polypeptide binding]; other site
1204414005783	metal binding residues [ion binding]; metal-binding site
1204414005784	3-fold/trimer interface [polypeptide binding]; other site
1204414005785	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
1204414005786	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1204414005787	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1204414005788	homodimer interface [polypeptide binding]; other site
1204414005789	catalytic residue [active]
1204414005790	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
1204414005791	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1204414005792	NAD binding site [chemical binding]; other site
1204414005793	dimerization interface [polypeptide binding]; other site
1204414005794	product binding site; other site
1204414005795	substrate binding site [chemical binding]; other site
1204414005796	zinc binding site [ion binding]; other site
1204414005797	catalytic residues [active]
1204414005798	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
1204414005799	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
1204414005800	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1204414005801	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1204414005802	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1204414005803	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
1204414005804	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
1204414005805	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
1204414005806	active site
1204414005807	catalytic site [active]
1204414005808	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1204414005809	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1204414005810	S-adenosylmethionine binding site [chemical binding]; other site
1204414005811	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1204414005812	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
1204414005813	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1204414005814	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1204414005815	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1204414005816	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1204414005817	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1204414005818	DNA binding site [nucleotide binding]
1204414005819	domain linker motif; other site
1204414005820	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1204414005821	dimerization interface [polypeptide binding]; other site
1204414005822	ligand binding site [chemical binding]; other site
1204414005823	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1204414005824	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1204414005825	Walker A/P-loop; other site
1204414005826	ATP binding site [chemical binding]; other site
1204414005827	Q-loop/lid; other site
1204414005828	ABC transporter signature motif; other site
1204414005829	Walker B; other site
1204414005830	D-loop; other site
1204414005831	H-loop/switch region; other site
1204414005832	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1204414005833	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1204414005834	ABC-ATPase subunit  interface; other site
1204414005835	dimer interface [polypeptide binding]; other site
1204414005836	putative PBP binding regions; other site
1204414005837	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1204414005838	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1204414005839	Predicted transcriptional regulators [Transcription]; Region: COG1733
1204414005840	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1204414005841	dimerization interface [polypeptide binding]; other site
1204414005842	putative DNA binding site [nucleotide binding]; other site
1204414005843	putative Zn2+ binding site [ion binding]; other site
1204414005844	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
1204414005845	active site
1204414005846	catalytic site [active]
1204414005847	substrate binding site [chemical binding]; other site
1204414005848	Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280
1204414005849	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
1204414005850	active site
1204414005851	catalytic site [active]
1204414005852	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1204414005853	synthetase active site [active]
1204414005854	NTP binding site [chemical binding]; other site
1204414005855	metal binding site [ion binding]; metal-binding site
1204414005856	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1204414005857	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
1204414005858	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1204414005859	RNA binding surface [nucleotide binding]; other site
1204414005860	Uncharacterized conserved protein [Function unknown]; Region: COG1739
1204414005861	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1204414005862	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1204414005863	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
1204414005864	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
1204414005865	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
1204414005866	catalytic site [active]
1204414005867	active site
1204414005868	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1204414005869	threonine dehydratase; Validated; Region: PRK08639
1204414005870	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1204414005871	tetramer interface [polypeptide binding]; other site
1204414005872	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1204414005873	catalytic residue [active]
1204414005874	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
1204414005875	putative Ile/Val binding site [chemical binding]; other site
1204414005876	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1204414005877	substrate binding site [chemical binding]; other site
1204414005878	THF binding site; other site
1204414005879	zinc-binding site [ion binding]; other site
1204414005880	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
1204414005881	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
1204414005882	active site
1204414005883	PHP Thumb interface [polypeptide binding]; other site
1204414005884	metal binding site [ion binding]; metal-binding site
1204414005885	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1204414005886	generic binding surface II; other site
1204414005887	generic binding surface I; other site
1204414005888	Predicted permeases [General function prediction only]; Region: RarD; COG2962
1204414005889	EamA-like transporter family; Region: EamA; cl17759
1204414005890	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1204414005891	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1204414005892	Cation efflux family; Region: Cation_efflux; pfam01545
1204414005893	oxidoreductase; Provisional; Region: PRK06128
1204414005894	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1204414005895	NAD(P) binding site [chemical binding]; other site
1204414005896	active site
1204414005897	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
1204414005898	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842
1204414005899	dimer interface [polypeptide binding]; other site
1204414005900	active site
1204414005901	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1204414005902	catalytic residues [active]
1204414005903	substrate binding site [chemical binding]; other site
1204414005904	2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945
1204414005905	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1204414005906	dimer interface [polypeptide binding]; other site
1204414005907	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1204414005908	catalytic residue [active]
1204414005909	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1204414005910	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1204414005911	active site
1204414005912	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
1204414005913	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1204414005914	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414005915	Walker A/P-loop; other site
1204414005916	ATP binding site [chemical binding]; other site
1204414005917	Q-loop/lid; other site
1204414005918	ABC transporter signature motif; other site
1204414005919	Walker B; other site
1204414005920	D-loop; other site
1204414005921	H-loop/switch region; other site
1204414005922	ABC transporter; Region: ABC_tran_2; pfam12848
1204414005923	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1204414005924	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1204414005925	active site
1204414005926	homotetramer interface [polypeptide binding]; other site
1204414005927	homodimer interface [polypeptide binding]; other site
1204414005928	DNA polymerase IV; Provisional; Region: PRK03348
1204414005929	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1204414005930	active site
1204414005931	DNA binding site [nucleotide binding]
1204414005932	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
1204414005933	Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788
1204414005934	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1204414005935	DNA binding residues [nucleotide binding]
1204414005936	putative dimer interface [polypeptide binding]; other site
1204414005937	HEAT repeats; Region: HEAT_2; pfam13646
1204414005938	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
1204414005939	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1204414005940	HIGH motif; other site
1204414005941	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1204414005942	active site
1204414005943	KMSKS motif; other site
1204414005944	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
1204414005945	tRNA binding surface [nucleotide binding]; other site
1204414005946	anticodon binding site; other site
1204414005947	DivIVA protein; Region: DivIVA; pfam05103
1204414005948	DivIVA domain; Region: DivI1A_domain; TIGR03544
1204414005949	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
1204414005950	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
1204414005951	Predicted integral membrane protein [Function unknown]; Region: COG0762
1204414005952	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
1204414005953	Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325
1204414005954	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1204414005955	catalytic residue [active]
1204414005956	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
1204414005957	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
1204414005958	cell division protein FtsZ; Validated; Region: PRK09330
1204414005959	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1204414005960	nucleotide binding site [chemical binding]; other site
1204414005961	SulA interaction site; other site
1204414005962	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
1204414005963	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1204414005964	Cell division protein FtsQ; Region: FtsQ; pfam03799
1204414005965	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1204414005966	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1204414005967	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1204414005968	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1204414005969	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1204414005970	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1204414005971	active site
1204414005972	homodimer interface [polypeptide binding]; other site
1204414005973	cell division protein FtsW; Region: ftsW; TIGR02614
1204414005974	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141
1204414005975	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1204414005976	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1204414005977	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1204414005978	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1204414005979	Mg++ binding site [ion binding]; other site
1204414005980	putative catalytic motif [active]
1204414005981	putative substrate binding site [chemical binding]; other site
1204414005982	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
1204414005983	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1204414005984	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1204414005985	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1204414005986	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1204414005987	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1204414005988	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1204414005989	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1204414005990	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1204414005991	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1204414005992	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1204414005993	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
1204414005994	MraW methylase family; Region: Methyltransf_5; cl17771
1204414005995	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
1204414005996	MraZ protein; Region: MraZ; pfam02381
1204414005997	MraZ protein; Region: MraZ; pfam02381
1204414005998	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
1204414005999	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1204414006000	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1204414006001	Coenzyme A binding pocket [chemical binding]; other site
1204414006002	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1204414006003	FAD binding site [chemical binding]; other site
1204414006004	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1204414006005	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1204414006006	substrate binding pocket [chemical binding]; other site
1204414006007	chain length determination region; other site
1204414006008	substrate-Mg2+ binding site; other site
1204414006009	catalytic residues [active]
1204414006010	aspartate-rich region 1; other site
1204414006011	active site lid residues [active]
1204414006012	aspartate-rich region 2; other site
1204414006013	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
1204414006014	Helix-turn-helix domain; Region: HTH_17; pfam12728
1204414006015	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1204414006016	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1204414006017	active site
1204414006018	ATP binding site [chemical binding]; other site
1204414006019	substrate binding site [chemical binding]; other site
1204414006020	activation loop (A-loop); other site
1204414006021	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
1204414006022	PASTA domain; Region: PASTA; pfam03793
1204414006023	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1204414006024	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1204414006025	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1204414006026	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1204414006027	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
1204414006028	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
1204414006029	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
1204414006030	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
1204414006031	Predicted esterase [General function prediction only]; Region: COG0627
1204414006032	Predicted membrane protein [Function unknown]; Region: COG4763
1204414006033	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1204414006034	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1204414006035	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1204414006036	putative acyl-acceptor binding pocket; other site
1204414006037	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
1204414006038	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1204414006039	nucleotide binding site [chemical binding]; other site
1204414006040	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1204414006041	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1204414006042	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
1204414006043	Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488
1204414006044	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1204414006045	NlpC/P60 family; Region: NLPC_P60; pfam00877
1204414006046	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1204414006047	NlpC/P60 family; Region: NLPC_P60; pfam00877
1204414006048	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
1204414006049	heme bH binding site [chemical binding]; other site
1204414006050	intrachain domain interface; other site
1204414006051	heme bL binding site [chemical binding]; other site
1204414006052	interchain domain interface [polypeptide binding]; other site
1204414006053	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
1204414006054	Qo binding site; other site
1204414006055	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
1204414006056	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
1204414006057	iron-sulfur cluster [ion binding]; other site
1204414006058	[2Fe-2S] cluster binding site [ion binding]; other site
1204414006059	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1204414006060	Cytochrome c; Region: Cytochrom_C; pfam00034
1204414006061	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1204414006062	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
1204414006063	Subunit I/III interface [polypeptide binding]; other site
1204414006064	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
1204414006065	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
1204414006066	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1204414006067	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
1204414006068	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1204414006069	active site
1204414006070	dimer interface [polypeptide binding]; other site
1204414006071	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1204414006072	Ligand Binding Site [chemical binding]; other site
1204414006073	Molecular Tunnel; other site
1204414006074	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1204414006075	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
1204414006076	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
1204414006077	homotrimer interface [polypeptide binding]; other site
1204414006078	Walker A motif; other site
1204414006079	GTP binding site [chemical binding]; other site
1204414006080	Walker B motif; other site
1204414006081	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
1204414006082	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
1204414006083	putative dimer interface [polypeptide binding]; other site
1204414006084	active site pocket [active]
1204414006085	putative cataytic base [active]
1204414006086	cobalamin synthase; Reviewed; Region: cobS; PRK00235
1204414006087	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1204414006088	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1204414006089	NAD(P) binding site [chemical binding]; other site
1204414006090	active site
1204414006091	Branched-chain amino acid aminotransferase; Region: DUF3665; pfam12427
1204414006092	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1204414006093	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1204414006094	homodimer interface [polypeptide binding]; other site
1204414006095	substrate-cofactor binding pocket; other site
1204414006096	catalytic residue [active]
1204414006097	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1204414006098	multifunctional aminopeptidase A; Provisional; Region: PRK00913
1204414006099	interface (dimer of trimers) [polypeptide binding]; other site
1204414006100	Substrate-binding/catalytic site; other site
1204414006101	Zn-binding sites [ion binding]; other site
1204414006102	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
1204414006103	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1204414006104	E3 interaction surface; other site
1204414006105	lipoyl attachment site [posttranslational modification]; other site
1204414006106	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1204414006107	E3 interaction surface; other site
1204414006108	lipoyl attachment site [posttranslational modification]; other site
1204414006109	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1204414006110	E3 interaction surface; other site
1204414006111	lipoyl attachment site [posttranslational modification]; other site
1204414006112	e3 binding domain; Region: E3_binding; pfam02817
1204414006113	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1204414006114	lipoate-protein ligase B; Provisional; Region: PRK14345
1204414006115	lipoyl synthase; Provisional; Region: PRK05481
1204414006116	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1204414006117	FeS/SAM binding site; other site
1204414006118	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
1204414006119	Predicted permease [General function prediction only]; Region: COG2985
1204414006120	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
1204414006121	TrkA-C domain; Region: TrkA_C; pfam02080
1204414006122	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
1204414006123	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1204414006124	Helix-turn-helix domain; Region: HTH_38; pfam13936
1204414006125	Homeodomain-like domain; Region: HTH_32; pfam13565
1204414006126	Integrase core domain; Region: rve; pfam00665
1204414006127	RDD family; Region: RDD; pfam06271
1204414006128	glutamine synthetase, type I; Region: GlnA; TIGR00653
1204414006129	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1204414006130	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1204414006131	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1204414006132	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676
1204414006133	nudix motif; other site
1204414006134	luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571
1204414006135	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1204414006136	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1204414006137	homotrimer interaction site [polypeptide binding]; other site
1204414006138	putative active site [active]
1204414006139	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
1204414006140	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
1204414006141	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1204414006142	catalytic residue [active]
1204414006143	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414006144	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1204414006145	putative substrate translocation pore; other site
1204414006146	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414006147	putative substrate translocation pore; other site
1204414006148	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
1204414006149	heme binding pocket [chemical binding]; other site
1204414006150	heme ligand [chemical binding]; other site
1204414006151	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
1204414006152	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1204414006153	metal binding triad; other site
1204414006154	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1204414006155	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1204414006156	metal binding triad; other site
1204414006157	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1204414006158	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1204414006159	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1204414006160	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1204414006161	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374
1204414006162	putative active site; other site
1204414006163	putative metal binding residues [ion binding]; other site
1204414006164	signature motif; other site
1204414006165	putative triphosphate binding site [ion binding]; other site
1204414006166	CHAD domain; Region: CHAD; pfam05235
1204414006167	CHAD domain; Region: CHAD; pfam05235
1204414006168	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
1204414006169	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
1204414006170	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1204414006171	RNB domain; Region: RNB; pfam00773
1204414006172	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
1204414006173	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
1204414006174	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
1204414006175	RNA/DNA hybrid binding site [nucleotide binding]; other site
1204414006176	active site
1204414006177	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1204414006178	catalytic core [active]
1204414006179	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
1204414006180	Putative zinc ribbon domain; Region: DUF164; pfam02591
1204414006181	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1204414006182	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1204414006183	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
1204414006184	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1204414006185	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1204414006186	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1204414006187	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1204414006188	motif II; other site
1204414006189	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1204414006190	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1204414006191	active site
1204414006192	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
1204414006193	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1204414006194	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1204414006195	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722
1204414006196	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1204414006197	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1204414006198	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
1204414006199	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
1204414006200	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
1204414006201	dimer interface [polypeptide binding]; other site
1204414006202	TPP-binding site [chemical binding]; other site
1204414006203	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
1204414006204	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414006205	Walker A/P-loop; other site
1204414006206	ATP binding site [chemical binding]; other site
1204414006207	Q-loop/lid; other site
1204414006208	ABC transporter signature motif; other site
1204414006209	Walker B; other site
1204414006210	D-loop; other site
1204414006211	H-loop/switch region; other site
1204414006212	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
1204414006213	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1204414006214	TM-ABC transporter signature motif; other site
1204414006215	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
1204414006216	zinc binding site [ion binding]; other site
1204414006217	putative ligand binding site [chemical binding]; other site
1204414006218	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1204414006219	Serine hydrolase; Region: Ser_hydrolase; cl17834
1204414006220	acyl carrier protein; Provisional; Region: acpP; PRK00982
1204414006221	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
1204414006222	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1204414006223	active site
1204414006224	motif I; other site
1204414006225	motif II; other site
1204414006226	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1204414006227	Uncharacterized conserved protein [Function unknown]; Region: COG4850
1204414006228	Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949
1204414006229	Beta-lactamase; Region: Beta-lactamase; pfam00144
1204414006230	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1204414006231	Domain of unknown function (DUF4274); Region: DUF4274; pfam14096
1204414006232	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
1204414006233	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
1204414006234	putative active site [active]
1204414006235	putative metal binding site [ion binding]; other site
1204414006236	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1204414006237	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
1204414006238	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
1204414006239	DNA primase; Validated; Region: dnaG; PRK05667
1204414006240	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1204414006241	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1204414006242	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1204414006243	active site
1204414006244	metal binding site [ion binding]; metal-binding site
1204414006245	interdomain interaction site; other site
1204414006246	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
1204414006247	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
1204414006248	RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607
1204414006249	active site
1204414006250	barstar interaction site; other site
1204414006251	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1204414006252	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1204414006253	glutaminase active site [active]
1204414006254	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1204414006255	dimer interface [polypeptide binding]; other site
1204414006256	active site
1204414006257	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1204414006258	dimer interface [polypeptide binding]; other site
1204414006259	active site
1204414006260	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
1204414006261	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1204414006262	Zn2+ binding site [ion binding]; other site
1204414006263	Mg2+ binding site [ion binding]; other site
1204414006264	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
1204414006265	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1204414006266	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1204414006267	putative active site [active]
1204414006268	Repair protein; Region: Repair_PSII; pfam04536
1204414006269	glycyl-tRNA synthetase; Provisional; Region: PRK04173
1204414006270	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1204414006271	motif 1; other site
1204414006272	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
1204414006273	active site
1204414006274	motif 2; other site
1204414006275	motif 3; other site
1204414006276	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
1204414006277	anticodon binding site; other site
1204414006278	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1204414006279	dimerization interface [polypeptide binding]; other site
1204414006280	putative DNA binding site [nucleotide binding]; other site
1204414006281	putative Zn2+ binding site [ion binding]; other site
1204414006282	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1204414006283	metal binding site 2 [ion binding]; metal-binding site
1204414006284	putative DNA binding helix; other site
1204414006285	metal binding site 1 [ion binding]; metal-binding site
1204414006286	dimer interface [polypeptide binding]; other site
1204414006287	structural Zn2+ binding site [ion binding]; other site
1204414006288	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1204414006289	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1204414006290	active site
1204414006291	Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044
1204414006292	diiron binding motif [ion binding]; other site
1204414006293	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433
1204414006294	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1204414006295	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1204414006296	catalytic residue [active]
1204414006297	putative FPP diphosphate  binding site; other site
1204414006298	putative FPP binding hydrophobic cleft; other site
1204414006299	dimer interface [polypeptide binding]; other site
1204414006300	putative IPP diphosphate binding site; other site
1204414006301	Recombination protein O N terminal; Region: RecO_N; pfam11967
1204414006302	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
1204414006303	Recombination protein O C terminal; Region: RecO_C; pfam02565
1204414006304	GTPase Era; Reviewed; Region: era; PRK00089
1204414006305	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1204414006306	G1 box; other site
1204414006307	GTP/Mg2+ binding site [chemical binding]; other site
1204414006308	Switch I region; other site
1204414006309	G2 box; other site
1204414006310	Switch II region; other site
1204414006311	G3 box; other site
1204414006312	G4 box; other site
1204414006313	G5 box; other site
1204414006314	KH domain; Region: KH_2; pfam07650
1204414006315	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1204414006316	Domain of unknown function DUF21; Region: DUF21; pfam01595
1204414006317	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1204414006318	Transporter associated domain; Region: CorC_HlyC; smart01091
1204414006319	metal-binding heat shock protein; Provisional; Region: PRK00016
1204414006320	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1204414006321	PhoH-like protein; Region: PhoH; pfam02562
1204414006322	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
1204414006323	RNA methyltransferase, RsmE family; Region: TIGR00046
1204414006324	chaperone protein DnaJ; Provisional; Region: PRK14278
1204414006325	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1204414006326	HSP70 interaction site [polypeptide binding]; other site
1204414006327	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1204414006328	Zn binding sites [ion binding]; other site
1204414006329	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1204414006330	dimer interface [polypeptide binding]; other site
1204414006331	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
1204414006332	coproporphyrinogen III oxidase; Validated; Region: PRK05628
1204414006333	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1204414006334	FeS/SAM binding site; other site
1204414006335	HemN C-terminal domain; Region: HemN_C; pfam06969
1204414006336	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1204414006337	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
1204414006338	acyl-activating enzyme (AAE) consensus motif; other site
1204414006339	putative AMP binding site [chemical binding]; other site
1204414006340	putative active site [active]
1204414006341	putative CoA binding site [chemical binding]; other site
1204414006342	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
1204414006343	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
1204414006344	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1204414006345	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
1204414006346	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1204414006347	Walker A/P-loop; other site
1204414006348	ATP binding site [chemical binding]; other site
1204414006349	Q-loop/lid; other site
1204414006350	ABC transporter signature motif; other site
1204414006351	Walker B; other site
1204414006352	D-loop; other site
1204414006353	H-loop/switch region; other site
1204414006354	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
1204414006355	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
1204414006356	active site
1204414006357	Zn binding site [ion binding]; other site
1204414006358	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
1204414006359	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1204414006360	substrate binding pocket [chemical binding]; other site
1204414006361	catalytic triad [active]
1204414006362	trehalose synthase; Region: treS_nterm; TIGR02456
1204414006363	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
1204414006364	active site
1204414006365	catalytic site [active]
1204414006366	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
1204414006367	Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
1204414006368	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
1204414006369	active site
1204414006370	metal binding site [ion binding]; metal-binding site
1204414006371	nudix motif; other site
1204414006372	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
1204414006373	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
1204414006374	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1204414006375	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1204414006376	homodimer interface [polypeptide binding]; other site
1204414006377	catalytic residue [active]
1204414006378	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1204414006379	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1204414006380	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1204414006381	choline/carnitine/betaine transport; Region: bcct; TIGR00842
1204414006382	Predicted permeases [General function prediction only]; Region: COG0679
1204414006383	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1204414006384	FAD binding domain; Region: FAD_binding_4; pfam01565
1204414006385	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1204414006386	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1204414006387	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1204414006388	DNA-binding site [nucleotide binding]; DNA binding site
1204414006389	FCD domain; Region: FCD; pfam07729
1204414006390	DctM-like transporters; Region: DctM; pfam06808
1204414006391	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
1204414006392	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1204414006393	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
1204414006394	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1204414006395	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1204414006396	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1204414006397	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1204414006398	dimer interface [polypeptide binding]; other site
1204414006399	conserved gate region; other site
1204414006400	putative PBP binding loops; other site
1204414006401	ABC-ATPase subunit interface; other site
1204414006402	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1204414006403	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1204414006404	Walker A/P-loop; other site
1204414006405	ATP binding site [chemical binding]; other site
1204414006406	Q-loop/lid; other site
1204414006407	ABC transporter signature motif; other site
1204414006408	Walker B; other site
1204414006409	D-loop; other site
1204414006410	H-loop/switch region; other site
1204414006411	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1204414006412	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1204414006413	Walker A/P-loop; other site
1204414006414	ATP binding site [chemical binding]; other site
1204414006415	Q-loop/lid; other site
1204414006416	ABC transporter signature motif; other site
1204414006417	Walker B; other site
1204414006418	D-loop; other site
1204414006419	H-loop/switch region; other site
1204414006420	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1204414006421	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
1204414006422	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1204414006423	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1204414006424	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1204414006425	substrate binding site [chemical binding]; other site
1204414006426	dimer interface [polypeptide binding]; other site
1204414006427	ATP binding site [chemical binding]; other site
1204414006428	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1204414006429	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
1204414006430	bile acid transporter; Region: bass; TIGR00841
1204414006431	Sodium Bile acid symporter family; Region: SBF; pfam01758
1204414006432	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
1204414006433	active site
1204414006434	phosphate binding residues; other site
1204414006435	catalytic residues [active]
1204414006436	malate synthase G; Provisional; Region: PRK02999
1204414006437	active site
1204414006438	isocitrate lyase; Provisional; Region: PRK15063
1204414006439	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1204414006440	tetramer interface [polypeptide binding]; other site
1204414006441	active site
1204414006442	Mg2+/Mn2+ binding site [ion binding]; other site
1204414006443	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
1204414006444	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1204414006445	putative active site [active]
1204414006446	putative metal binding site [ion binding]; other site
1204414006447	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
1204414006448	Lamin Tail Domain; Region: LTD; pfam00932
1204414006449	DctM-like transporters; Region: DctM; pfam06808
1204414006450	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
1204414006451	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
1204414006452	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1204414006453	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
1204414006454	GTP-binding protein LepA; Provisional; Region: PRK05433
1204414006455	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1204414006456	G1 box; other site
1204414006457	putative GEF interaction site [polypeptide binding]; other site
1204414006458	GTP/Mg2+ binding site [chemical binding]; other site
1204414006459	Switch I region; other site
1204414006460	G2 box; other site
1204414006461	G3 box; other site
1204414006462	Switch II region; other site
1204414006463	G4 box; other site
1204414006464	G5 box; other site
1204414006465	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1204414006466	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1204414006467	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1204414006468	PemK-like protein; Region: PemK; pfam02452
1204414006469	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1204414006470	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1204414006471	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
1204414006472	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1204414006473	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
1204414006474	hypothetical protein; Validated; Region: PRK05629
1204414006475	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1204414006476	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
1204414006477	Competence protein; Region: Competence; pfam03772
1204414006478	SLBB domain; Region: SLBB; pfam10531
1204414006479	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
1204414006480	Helix-hairpin-helix motif; Region: HHH; pfam00633
1204414006481	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307
1204414006482	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1204414006483	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1204414006484	catalytic core [active]
1204414006485	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
1204414006486	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
1204414006487	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1204414006488	active site
1204414006489	(T/H)XGH motif; other site
1204414006490	Cutinase; Region: Cutinase; pfam01083
1204414006491	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1204414006492	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1204414006493	putative catalytic cysteine [active]
1204414006494	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159
1204414006495	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1204414006496	putative ligand binding site [chemical binding]; other site
1204414006497	putative NAD binding site [chemical binding]; other site
1204414006498	catalytic site [active]
1204414006499	glutamate 5-kinase; Region: proB; TIGR01027
1204414006500	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1204414006501	nucleotide binding site [chemical binding]; other site
1204414006502	homotetrameric interface [polypeptide binding]; other site
1204414006503	putative phosphate binding site [ion binding]; other site
1204414006504	putative allosteric binding site; other site
1204414006505	PUA domain; Region: PUA; pfam01472
1204414006506	GTPase CgtA; Reviewed; Region: obgE; PRK12296
1204414006507	GTP1/OBG; Region: GTP1_OBG; pfam01018
1204414006508	Obg GTPase; Region: Obg; cd01898
1204414006509	G1 box; other site
1204414006510	GTP/Mg2+ binding site [chemical binding]; other site
1204414006511	Switch I region; other site
1204414006512	G2 box; other site
1204414006513	G3 box; other site
1204414006514	Switch II region; other site
1204414006515	G4 box; other site
1204414006516	G5 box; other site
1204414006517	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
1204414006518	xanthine permease; Region: pbuX; TIGR03173
1204414006519	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195
1204414006520	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1204414006521	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1204414006522	active site
1204414006523	catalytic tetrad [active]
1204414006524	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1204414006525	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1204414006526	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
1204414006527	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1204414006528	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
1204414006529	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1204414006530	homodimer interface [polypeptide binding]; other site
1204414006531	oligonucleotide binding site [chemical binding]; other site
1204414006532	Pirin-related protein [General function prediction only]; Region: COG1741
1204414006533	Pirin; Region: Pirin; pfam02678
1204414006534	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1204414006535	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1204414006536	Pirin-related protein [General function prediction only]; Region: COG1741
1204414006537	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
1204414006538	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1204414006539	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1204414006540	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1204414006541	active site
1204414006542	multimer interface [polypeptide binding]; other site
1204414006543	Predicted acetyltransferase [General function prediction only]; Region: COG2388
1204414006544	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
1204414006545	hydrophobic ligand binding site; other site
1204414006546	Protein of unknown function (DUF4233); Region: DUF4233; pfam14017
1204414006547	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1204414006548	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1204414006549	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1204414006550	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1204414006551	active site
1204414006552	HIGH motif; other site
1204414006553	nucleotide binding site [chemical binding]; other site
1204414006554	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1204414006555	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1204414006556	active site
1204414006557	KMSKS motif; other site
1204414006558	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1204414006559	tRNA binding surface [nucleotide binding]; other site
1204414006560	anticodon binding site; other site
1204414006561	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1204414006562	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1204414006563	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
1204414006564	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
1204414006565	Actin-like ATPase involved in cell morphogenesis [Cell division and chromosome partitioning]; Region: MreB; COG1077
1204414006566	nucleotide binding site [chemical binding]; other site
1204414006567	putative NEF/HSP70 interaction site [polypeptide binding]; other site
1204414006568	SBD interface [polypeptide binding]; other site
1204414006569	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
1204414006570	malate dehydrogenase; Provisional; Region: PRK05442
1204414006571	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
1204414006572	NAD(P) binding site [chemical binding]; other site
1204414006573	dimer interface [polypeptide binding]; other site
1204414006574	malate binding site [chemical binding]; other site
1204414006575	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1204414006576	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1204414006577	Predicted transcriptional regulators [Transcription]; Region: COG1695
1204414006578	Transcriptional regulator PadR-like family; Region: PadR; cl17335
1204414006579	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1204414006580	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1204414006581	iron-sulfur cluster [ion binding]; other site
1204414006582	[2Fe-2S] cluster binding site [ion binding]; other site
1204414006583	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
1204414006584	alpha subunit interface [polypeptide binding]; other site
1204414006585	active site
1204414006586	substrate binding site [chemical binding]; other site
1204414006587	Fe binding site [ion binding]; other site
1204414006588	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1204414006589	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1204414006590	FMN-binding pocket [chemical binding]; other site
1204414006591	flavin binding motif; other site
1204414006592	phosphate binding motif [ion binding]; other site
1204414006593	beta-alpha-beta structure motif; other site
1204414006594	NAD binding pocket [chemical binding]; other site
1204414006595	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1204414006596	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1204414006597	catalytic loop [active]
1204414006598	iron binding site [ion binding]; other site
1204414006599	benzoate transport; Region: 2A0115; TIGR00895
1204414006600	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414006601	putative substrate translocation pore; other site
1204414006602	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414006603	Predicted permeases [General function prediction only]; Region: COG0679
1204414006604	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1204414006605	ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994
1204414006606	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
1204414006607	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1204414006608	Walker A motif; other site
1204414006609	ATP binding site [chemical binding]; other site
1204414006610	Walker B motif; other site
1204414006611	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1204414006612	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844
1204414006613	active site
1204414006614	catalytic triad [active]
1204414006615	oxyanion hole [active]
1204414006616	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
1204414006617	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
1204414006618	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
1204414006619	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1204414006620	Bacterial transcriptional regulator; Region: IclR; pfam01614
1204414006621	acetyl-CoA acetyltransferase; Provisional; Region: PRK06205
1204414006622	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1204414006623	dimer interface [polypeptide binding]; other site
1204414006624	active site
1204414006625	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
1204414006626	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1204414006627	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1204414006628	DNA binding residues [nucleotide binding]
1204414006629	dimerization interface [polypeptide binding]; other site
1204414006630	4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425
1204414006631	3-carboxy-cis,cis-muconate cycloisomerase; Region: protocat_pcaB; TIGR02426
1204414006632	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
1204414006633	tetramer interface [polypeptide binding]; other site
1204414006634	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
1204414006635	protocatechuate 3,4-dioxygenase, alpha subunit; Region: protocat_alph; TIGR02423
1204414006636	active site
1204414006637	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
1204414006638	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
1204414006639	active site
1204414006640	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1204414006641	active site
1204414006642	Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829
1204414006643	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
1204414006644	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
1204414006645	metal binding site [ion binding]; metal-binding site
1204414006646	substrate binding pocket [chemical binding]; other site
1204414006647	catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438
1204414006648	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
1204414006649	active site
1204414006650	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
1204414006651	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1204414006652	iron-sulfur cluster [ion binding]; other site
1204414006653	[2Fe-2S] cluster binding site [ion binding]; other site
1204414006654	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
1204414006655	putative alpha subunit interface [polypeptide binding]; other site
1204414006656	putative active site [active]
1204414006657	putative substrate binding site [chemical binding]; other site
1204414006658	Fe binding site [ion binding]; other site
1204414006659	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
1204414006660	inter-subunit interface; other site
1204414006661	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
1204414006662	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1204414006663	catalytic loop [active]
1204414006664	iron binding site [ion binding]; other site
1204414006665	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
1204414006666	FAD binding pocket [chemical binding]; other site
1204414006667	FAD binding motif [chemical binding]; other site
1204414006668	phosphate binding motif [ion binding]; other site
1204414006669	beta-alpha-beta structure motif; other site
1204414006670	NAD binding pocket [chemical binding]; other site
1204414006671	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1204414006672	FCD domain; Region: FCD; pfam07729
1204414006673	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823
1204414006674	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1204414006675	NAD(P) binding site [chemical binding]; other site
1204414006676	active site
1204414006677	AAA ATPase domain; Region: AAA_16; pfam13191
1204414006678	AAA domain; Region: AAA_22; pfam13401
1204414006679	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1204414006680	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1204414006681	DNA binding residues [nucleotide binding]
1204414006682	dimerization interface [polypeptide binding]; other site
1204414006683	benzoate transport; Region: 2A0115; TIGR00895
1204414006684	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414006685	putative substrate translocation pore; other site
1204414006686	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414006687	Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135
1204414006688	benzoate transporter; Region: benE; TIGR00843
1204414006689	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
1204414006690	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1204414006691	oligomer interface [polypeptide binding]; other site
1204414006692	active site residues [active]
1204414006693	Clp protease; Region: CLP_protease; pfam00574
1204414006694	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1204414006695	oligomer interface [polypeptide binding]; other site
1204414006696	active site residues [active]
1204414006697	trigger factor; Provisional; Region: tig; PRK01490
1204414006698	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1204414006699	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1204414006700	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1204414006701	dimerization interface [polypeptide binding]; other site
1204414006702	putative DNA binding site [nucleotide binding]; other site
1204414006703	putative Zn2+ binding site [ion binding]; other site
1204414006704	Beta-lactamase; Region: Beta-lactamase; pfam00144
1204414006705	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1204414006706	RDD family; Region: RDD; pfam06271
1204414006707	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
1204414006708	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
1204414006709	Predicted membrane protein [Function unknown]; Region: COG2311
1204414006710	Protein of unknown function (DUF418); Region: DUF418; pfam04235
1204414006711	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1204414006712	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1204414006713	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
1204414006714	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
1204414006715	Zn binding site [ion binding]; other site
1204414006716	Uncharacterized conserved protein [Function unknown]; Region: COG4748
1204414006717	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
1204414006718	phytoene desaturase; Region: crtI_fam; TIGR02734
1204414006719	phytoene desaturase; Region: crtI_fam; TIGR02734
1204414006720	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1204414006721	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
1204414006722	active site lid residues [active]
1204414006723	substrate binding pocket [chemical binding]; other site
1204414006724	catalytic residues [active]
1204414006725	substrate-Mg2+ binding site; other site
1204414006726	aspartate-rich region 1; other site
1204414006727	aspartate-rich region 2; other site
1204414006728	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414006729	putative substrate translocation pore; other site
1204414006730	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1204414006731	CMD domain protein, Avi_7170 family; Region: CMD_Avi_7170; TIGR04029
1204414006732	alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030
1204414006733	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
1204414006734	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1204414006735	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1204414006736	Walker A/P-loop; other site
1204414006737	ATP binding site [chemical binding]; other site
1204414006738	Q-loop/lid; other site
1204414006739	ABC transporter signature motif; other site
1204414006740	Walker B; other site
1204414006741	D-loop; other site
1204414006742	H-loop/switch region; other site
1204414006743	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1204414006744	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1204414006745	Walker A/P-loop; other site
1204414006746	ATP binding site [chemical binding]; other site
1204414006747	Q-loop/lid; other site
1204414006748	ABC transporter signature motif; other site
1204414006749	Walker B; other site
1204414006750	D-loop; other site
1204414006751	H-loop/switch region; other site
1204414006752	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1204414006753	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1204414006754	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1204414006755	putative PBP binding loops; other site
1204414006756	dimer interface [polypeptide binding]; other site
1204414006757	ABC-ATPase subunit interface; other site
1204414006758	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1204414006759	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1204414006760	dimer interface [polypeptide binding]; other site
1204414006761	conserved gate region; other site
1204414006762	putative PBP binding loops; other site
1204414006763	ABC-ATPase subunit interface; other site
1204414006764	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1204414006765	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492
1204414006766	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
1204414006767	hypothetical protein; Provisional; Region: PRK06062
1204414006768	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1204414006769	inhibitor-cofactor binding pocket; inhibition site
1204414006770	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1204414006771	catalytic residue [active]
1204414006772	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1204414006773	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1204414006774	active site
1204414006775	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1204414006776	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1204414006777	short chain dehydrogenase; Provisional; Region: PRK08219
1204414006778	HetN oxidoreductase-like, classical (c) SDR; Region: HetN_like_SDR_c; cd08932
1204414006779	putative NAD(P) binding site [chemical binding]; other site
1204414006780	active site
1204414006781	tetracycline repressor protein TetR; Provisional; Region: PRK13756
1204414006782	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1204414006783	cystathionine gamma-synthase; Provisional; Region: PRK07811
1204414006784	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1204414006785	homodimer interface [polypeptide binding]; other site
1204414006786	substrate-cofactor binding pocket; other site
1204414006787	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1204414006788	catalytic residue [active]
1204414006789	ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119
1204414006790	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414006791	Walker A/P-loop; other site
1204414006792	ATP binding site [chemical binding]; other site
1204414006793	Q-loop/lid; other site
1204414006794	ABC transporter signature motif; other site
1204414006795	Walker B; other site
1204414006796	D-loop; other site
1204414006797	H-loop/switch region; other site
1204414006798	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
1204414006799	apolar tunnel; other site
1204414006800	heme binding site [chemical binding]; other site
1204414006801	dimerization interface [polypeptide binding]; other site
1204414006802	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
1204414006803	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
1204414006804	Chromate transporter; Region: Chromate_transp; pfam02417
1204414006805	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1204414006806	active site
1204414006807	Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524
1204414006808	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
1204414006809	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
1204414006810	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414006811	Walker A/P-loop; other site
1204414006812	ATP binding site [chemical binding]; other site
1204414006813	Q-loop/lid; other site
1204414006814	ABC transporter signature motif; other site
1204414006815	Walker B; other site
1204414006816	D-loop; other site
1204414006817	H-loop/switch region; other site
1204414006818	ABC transporter; Region: ABC_tran_2; pfam12848
1204414006819	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1204414006820	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1204414006821	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1204414006822	dimer interface [polypeptide binding]; other site
1204414006823	ssDNA binding site [nucleotide binding]; other site
1204414006824	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1204414006825	Copper resistance protein D; Region: CopD; cl00563
1204414006826	Predicted membrane protein [Function unknown]; Region: COG3336
1204414006827	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
1204414006828	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
1204414006829	active site
1204414006830	dimer interface [polypeptide binding]; other site
1204414006831	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1204414006832	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1204414006833	dimer interface [polypeptide binding]; other site
1204414006834	conserved gate region; other site
1204414006835	putative PBP binding loops; other site
1204414006836	ABC-ATPase subunit interface; other site
1204414006837	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1204414006838	dimer interface [polypeptide binding]; other site
1204414006839	conserved gate region; other site
1204414006840	putative PBP binding loops; other site
1204414006841	ABC-ATPase subunit interface; other site
1204414006842	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1204414006843	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1204414006844	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
1204414006845	Domain of unknown function (DUF4032); Region: DUF4032; pfam13224
1204414006846	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1204414006847	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1204414006848	Walker A/P-loop; other site
1204414006849	ATP binding site [chemical binding]; other site
1204414006850	Q-loop/lid; other site
1204414006851	ABC transporter signature motif; other site
1204414006852	Walker B; other site
1204414006853	D-loop; other site
1204414006854	H-loop/switch region; other site
1204414006855	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1204414006856	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1204414006857	active site
1204414006858	catalytic residues [active]
1204414006859	DNA binding site [nucleotide binding]
1204414006860	Int/Topo IB signature motif; other site
1204414006861	C2 domain; Region: C2; cl14603
1204414006862	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1204414006863	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1204414006864	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1204414006865	catalytic residues [active]
1204414006866	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1204414006867	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
1204414006868	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
1204414006869	AIR carboxylase; Region: AIRC; smart01001
1204414006870	Uncharacterized conserved protein [Function unknown]; Region: COG1641
1204414006871	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
1204414006872	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1204414006873	classical (c) SDRs; Region: SDR_c; cd05233
1204414006874	NAD(P) binding site [chemical binding]; other site
1204414006875	active site
1204414006876	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1204414006877	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
1204414006878	catalytic site [active]
1204414006879	putative active site [active]
1204414006880	putative substrate binding site [chemical binding]; other site
1204414006881	dimer interface [polypeptide binding]; other site
1204414006882	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
1204414006883	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
1204414006884	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506
1204414006885	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
1204414006886	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1204414006887	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1204414006888	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
1204414006889	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1204414006890	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1204414006891	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1204414006892	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
1204414006893	glutaminase; Provisional; Region: PRK00971
1204414006894	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
1204414006895	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1204414006896	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1204414006897	dimerization interface [polypeptide binding]; other site
1204414006898	ligand binding site [chemical binding]; other site
1204414006899	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1204414006900	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1204414006901	glucuronate isomerase; Reviewed; Region: PRK02925
1204414006902	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
1204414006903	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
1204414006904	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
1204414006905	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1204414006906	active site
1204414006907	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
1204414006908	Isochorismatase family; Region: Isochorismatase; pfam00857
1204414006909	catalytic triad [active]
1204414006910	metal binding site [ion binding]; metal-binding site
1204414006911	conserved cis-peptide bond; other site
1204414006912	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
1204414006913	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1204414006914	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1204414006915	catalytic triad [active]
1204414006916	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1204414006917	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1204414006918	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1204414006919	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414006920	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1204414006921	putative substrate translocation pore; other site
1204414006922	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1204414006923	Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981
1204414006924	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1204414006925	phosphate binding site [ion binding]; other site
1204414006926	Domain of unknown function (DUF1729); Region: DUF1729; pfam08354
1204414006927	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1204414006928	active site 2 [active]
1204414006929	active site 1 [active]
1204414006930	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1204414006931	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1204414006932	3-oxoacyl-[acyl-carrier protein]; Region: COG4982
1204414006933	ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950
1204414006934	putative NAD(P) binding site [chemical binding]; other site
1204414006935	active site
1204414006936	"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828
1204414006937	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
1204414006938	active site
1204414006939	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1204414006940	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1204414006941	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1204414006942	Peptidase family M23; Region: Peptidase_M23; pfam01551
1204414006943	Glucitol operon activator [Transcription]; Region: GutM; COG4578
1204414006944	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
1204414006945	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1204414006946	active site
1204414006947	dimerization interface [polypeptide binding]; other site
1204414006948	ribonuclease PH; Reviewed; Region: rph; PRK00173
1204414006949	Ribonuclease PH; Region: RNase_PH_bact; cd11362
1204414006950	hexamer interface [polypeptide binding]; other site
1204414006951	active site
1204414006952	DDE domain; Region: DDE_Tnp_IS240; pfam13610
1204414006953	Integrase core domain; Region: rve; pfam00665
1204414006954	Predicted membrane protein [Function unknown]; Region: COG4325
1204414006955	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
1204414006956	DDE domain; Region: DDE_Tnp_IS240; pfam13610
1204414006957	Integrase core domain; Region: rve; pfam00665
1204414006958	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
1204414006959	glutamate racemase; Provisional; Region: PRK00865
1204414006960	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1204414006961	MarR family; Region: MarR; pfam01047
1204414006962	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
1204414006963	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
1204414006964	putative active site pocket [active]
1204414006965	cleavage site
1204414006966	Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
1204414006967	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
1204414006968	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1204414006969	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1204414006970	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
1204414006971	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
1204414006972	active site
1204414006973	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
1204414006974	DEAD/DEAH box helicase; Region: DEAD; pfam00270
1204414006975	DEAD_2; Region: DEAD_2; pfam06733
1204414006976	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1204414006977	Prion/Doppel alpha-helical domain; Region: Prion; cl02493
1204414006978	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
1204414006979	Peptidyl-tRNA hydrolase [Translation, ribosomal structure and biogenesis]; Region: pth2; COG1990
1204414006980	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
1204414006981	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
1204414006982	phosphoserine phosphatase SerB; Region: serB; TIGR00338
1204414006983	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1204414006984	motif II; other site
1204414006985	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1204414006986	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1204414006987	D-pathway; other site
1204414006988	Putative ubiquinol binding site [chemical binding]; other site
1204414006989	Low-spin heme (heme b) binding site [chemical binding]; other site
1204414006990	Putative water exit pathway; other site
1204414006991	Binuclear center (heme o3/CuB) [ion binding]; other site
1204414006992	K-pathway; other site
1204414006993	Putative proton exit pathway; other site
1204414006994	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1204414006995	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1204414006996	dimer interface [polypeptide binding]; other site
1204414006997	putative radical transfer pathway; other site
1204414006998	diiron center [ion binding]; other site
1204414006999	tyrosyl radical; other site
1204414007000	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
1204414007001	Ferritin-like domain; Region: Ferritin; pfam00210
1204414007002	ferroxidase diiron center [ion binding]; other site
1204414007003	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1204414007004	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1204414007005	DNA-binding site [nucleotide binding]; DNA binding site
1204414007006	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1204414007007	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
1204414007008	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1204414007009	non-specific DNA interactions [nucleotide binding]; other site
1204414007010	DNA binding site [nucleotide binding]
1204414007011	sequence specific DNA binding site [nucleotide binding]; other site
1204414007012	putative cAMP binding site [chemical binding]; other site
1204414007013	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1204414007014	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
1204414007015	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
1204414007016	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1204414007017	active site
1204414007018	dimer interface [polypeptide binding]; other site
1204414007019	catalytic residues [active]
1204414007020	effector binding site; other site
1204414007021	R2 peptide binding site; other site
1204414007022	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
1204414007023	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1204414007024	catalytic residues [active]
1204414007025	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
1204414007026	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1204414007027	homodimer interface [polypeptide binding]; other site
1204414007028	NAD binding pocket [chemical binding]; other site
1204414007029	ATP binding pocket [chemical binding]; other site
1204414007030	Mg binding site [ion binding]; other site
1204414007031	active-site loop [active]
1204414007032	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3001
1204414007033	Phosphotransferase enzyme family; Region: APH; pfam01636
1204414007034	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
1204414007035	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
1204414007036	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
1204414007037	NADP binding site [chemical binding]; other site
1204414007038	dimer interface [polypeptide binding]; other site
1204414007039	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
1204414007040	(2R)-phospho-3-sulfolactate synthase (PSL synthase, CoM    biosynthesis) [Coenzyme transport and metabolism]; Region: COG1809
1204414007041	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
1204414007042	phosphoglucomutase; Validated; Region: PRK07564
1204414007043	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
1204414007044	active site
1204414007045	substrate binding site [chemical binding]; other site
1204414007046	metal binding site [ion binding]; metal-binding site
1204414007047	camphor resistance protein CrcB; Provisional; Region: ccrB; PRK00134
1204414007048	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
1204414007049	hypothetical protein; Provisional; Region: PRK05463
1204414007050	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1204414007051	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
1204414007052	LGFP repeat; Region: LGFP; pfam08310
1204414007053	LGFP repeat; Region: LGFP; pfam08310
1204414007054	LGFP repeat; Region: LGFP; pfam08310
1204414007055	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
1204414007056	DDE superfamily endonuclease; Region: DDE_3; pfam13358
1204414007057	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1204414007058	Predicted membrane protein [General function prediction only]; Region: COG4194
1204414007059	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
1204414007060	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
1204414007061	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1204414007062	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
1204414007063	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1204414007064	FtsX-like permease family; Region: FtsX; pfam02687
1204414007065	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1204414007066	FtsX-like permease family; Region: FtsX; pfam02687
1204414007067	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1204414007068	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1204414007069	Walker A/P-loop; other site
1204414007070	ATP binding site [chemical binding]; other site
1204414007071	Q-loop/lid; other site
1204414007072	ABC transporter signature motif; other site
1204414007073	Walker B; other site
1204414007074	D-loop; other site
1204414007075	H-loop/switch region; other site
1204414007076	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1204414007077	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1204414007078	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1204414007079	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1204414007080	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1204414007081	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1204414007082	S-adenosylmethionine binding site [chemical binding]; other site
1204414007083	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1204414007084	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1204414007085	hinge; other site
1204414007086	active site
1204414007087	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
1204414007088	GAF domain; Region: GAF_2; pfam13185
1204414007089	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1204414007090	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1204414007091	DNA binding residues [nucleotide binding]
1204414007092	dimerization interface [polypeptide binding]; other site
1204414007093	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1204414007094	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1204414007095	dimer interface [polypeptide binding]; other site
1204414007096	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1204414007097	catalytic residue [active]
1204414007098	serine O-acetyltransferase; Region: cysE; TIGR01172
1204414007099	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1204414007100	trimer interface [polypeptide binding]; other site
1204414007101	active site
1204414007102	substrate binding site [chemical binding]; other site
1204414007103	CoA binding site [chemical binding]; other site
1204414007104	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1204414007105	Coenzyme A binding pocket [chemical binding]; other site
1204414007106	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1204414007107	CoA binding domain; Region: CoA_binding; smart00881
1204414007108	CoA-ligase; Region: Ligase_CoA; pfam00549
1204414007109	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1204414007110	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1204414007111	CoA-ligase; Region: Ligase_CoA; pfam00549
1204414007112	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
1204414007113	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
1204414007114	catalytic residues [active]
1204414007115	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1204414007116	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
1204414007117	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
1204414007118	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
1204414007119	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
1204414007120	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1204414007121	FMN binding site [chemical binding]; other site
1204414007122	active site
1204414007123	catalytic residues [active]
1204414007124	substrate binding site [chemical binding]; other site
1204414007125	Phosphate uptake regulator [Inorganic ion transport and metabolism]; Region: PhoU; COG0704
1204414007126	PhoU domain; Region: PhoU; pfam01895
1204414007127	PhoU domain; Region: PhoU; pfam01895
1204414007128	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
1204414007129	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1204414007130	Walker A/P-loop; other site
1204414007131	ATP binding site [chemical binding]; other site
1204414007132	Q-loop/lid; other site
1204414007133	ABC transporter signature motif; other site
1204414007134	Walker B; other site
1204414007135	D-loop; other site
1204414007136	H-loop/switch region; other site
1204414007137	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1204414007138	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1204414007139	dimer interface [polypeptide binding]; other site
1204414007140	conserved gate region; other site
1204414007141	putative PBP binding loops; other site
1204414007142	ABC-ATPase subunit interface; other site
1204414007143	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1204414007144	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1204414007145	dimer interface [polypeptide binding]; other site
1204414007146	conserved gate region; other site
1204414007147	putative PBP binding loops; other site
1204414007148	ABC-ATPase subunit interface; other site
1204414007149	PBP superfamily domain; Region: PBP_like_2; cl17296
1204414007150	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
1204414007151	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1204414007152	Coenzyme A binding pocket [chemical binding]; other site
1204414007153	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1204414007154	Coenzyme A binding pocket [chemical binding]; other site
1204414007155	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
1204414007156	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1204414007157	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1204414007158	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
1204414007159	heme-binding site [chemical binding]; other site
1204414007160	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1204414007161	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
1204414007162	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1204414007163	catalytic residue [active]
1204414007164	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
1204414007165	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
1204414007166	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1204414007167	Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
1204414007168	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1204414007169	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1204414007170	dimerization interface [polypeptide binding]; other site
1204414007171	putative ATP binding site [chemical binding]; other site
1204414007172	amidophosphoribosyltransferase; Provisional; Region: PRK07847
1204414007173	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1204414007174	active site
1204414007175	tetramer interface [polypeptide binding]; other site
1204414007176	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1204414007177	active site
1204414007178	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1204414007179	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1204414007180	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
1204414007181	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1204414007182	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
1204414007183	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1204414007184	dimerization interface [polypeptide binding]; other site
1204414007185	ATP binding site [chemical binding]; other site
1204414007186	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1204414007187	dimerization interface [polypeptide binding]; other site
1204414007188	ATP binding site [chemical binding]; other site
1204414007189	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
1204414007190	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1204414007191	putative active site [active]
1204414007192	catalytic triad [active]
1204414007193	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
1204414007194	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1204414007195	catalytic residues [active]
1204414007196	dimer interface [polypeptide binding]; other site
1204414007197	Predicted extracellular nuclease [General function prediction only]; Region: COG2374
1204414007198	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
1204414007199	generic binding surface II; other site
1204414007200	generic binding surface I; other site
1204414007201	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
1204414007202	putative active site [active]
1204414007203	putative catalytic site [active]
1204414007204	putative Mg binding site IVb [ion binding]; other site
1204414007205	putative phosphate binding site [ion binding]; other site
1204414007206	putative DNA binding site [nucleotide binding]; other site
1204414007207	putative Mg binding site IVa [ion binding]; other site
1204414007208	Predicted deacetylase [General function prediction only]; Region: COG3233
1204414007209	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374
1204414007210	putative active site [active]
1204414007211	putative Zn binding site [ion binding]; other site
1204414007212	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1204414007213	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1204414007214	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
1204414007215	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1204414007216	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
1204414007217	ATP binding site [chemical binding]; other site
1204414007218	active site
1204414007219	substrate binding site [chemical binding]; other site
1204414007220	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
1204414007221	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
1204414007222	tetramer interface [polypeptide binding]; other site
1204414007223	aspartate aminotransferase; Provisional; Region: PRK05764
1204414007224	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1204414007225	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1204414007226	homodimer interface [polypeptide binding]; other site
1204414007227	catalytic residue [active]
1204414007228	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1204414007229	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1204414007230	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1204414007231	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1204414007232	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
1204414007233	nucleotide binding site/active site [active]
1204414007234	HIT family signature motif; other site
1204414007235	catalytic residue [active]
1204414007236	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1204414007237	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1204414007238	S-adenosylmethionine binding site [chemical binding]; other site
1204414007239	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1204414007240	POT family; Region: PTR2; cl17359
1204414007241	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05630
1204414007242	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1204414007243	inhibitor-cofactor binding pocket; inhibition site
1204414007244	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1204414007245	catalytic residue [active]
1204414007246	AAA domain; Region: AAA_26; pfam13500
1204414007247	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1204414007248	Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109
1204414007249	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1204414007250	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1204414007251	dimerization interface [polypeptide binding]; other site
1204414007252	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1204414007253	dimer interface [polypeptide binding]; other site
1204414007254	phosphorylation site [posttranslational modification]
1204414007255	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1204414007256	ATP binding site [chemical binding]; other site
1204414007257	Mg2+ binding site [ion binding]; other site
1204414007258	G-X-G motif; other site
1204414007259	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1204414007260	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1204414007261	active site
1204414007262	phosphorylation site [posttranslational modification]
1204414007263	intermolecular recognition site; other site
1204414007264	dimerization interface [polypeptide binding]; other site
1204414007265	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1204414007266	DNA binding site [nucleotide binding]
1204414007267	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1204414007268	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1204414007269	DNA binding residues [nucleotide binding]
1204414007270	dimer interface [polypeptide binding]; other site
1204414007271	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
1204414007272	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
1204414007273	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820
1204414007274	dimer interface [polypeptide binding]; other site
1204414007275	active site
1204414007276	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1204414007277	substrate binding site [chemical binding]; other site
1204414007278	catalytic residue [active]
1204414007279	pyruvate dehydrogenase; Provisional; Region: PRK06546
1204414007280	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1204414007281	PYR/PP interface [polypeptide binding]; other site
1204414007282	dimer interface [polypeptide binding]; other site
1204414007283	tetramer interface [polypeptide binding]; other site
1204414007284	TPP binding site [chemical binding]; other site
1204414007285	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1204414007286	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1204414007287	TPP-binding site [chemical binding]; other site
1204414007288	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414007289	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1204414007290	putative substrate translocation pore; other site
1204414007291	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414007292	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1204414007293	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
1204414007294	Ion channel regulatory protein UNC-93; Region: UNC-93; pfam05978
1204414007295	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414007296	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
1204414007297	active site
1204414007298	catalytic residues [active]
1204414007299	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
1204414007300	active site
1204414007301	catalytic residues [active]
1204414007302	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843
1204414007303	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1204414007304	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1204414007305	dimerization interface [polypeptide binding]; other site
1204414007306	substrate binding pocket [chemical binding]; other site
1204414007307	diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921
1204414007308	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl17742
1204414007309	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
1204414007310	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
1204414007311	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1204414007312	active site
1204414007313	motif I; other site
1204414007314	motif II; other site
1204414007315	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1204414007316	Uncharacterized conserved protein [Function unknown]; Region: COG5646
1204414007317	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
1204414007318	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1204414007319	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1204414007320	Uncharacterized conserved protein [Function unknown]; Region: COG3610
1204414007321	Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380
1204414007322	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
1204414007323	active site
1204414007324	homotetramer interface [polypeptide binding]; other site
1204414007325	META domain; Region: META; cl01245
1204414007326	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
1204414007327	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
1204414007328	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1204414007329	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1204414007330	DNA binding site [nucleotide binding]
1204414007331	domain linker motif; other site
1204414007332	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279
1204414007333	putative dimerization interface [polypeptide binding]; other site
1204414007334	putative ligand binding site [chemical binding]; other site
1204414007335	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1204414007336	Metal binding protein TroA_b.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020
1204414007337	metal binding site [ion binding]; metal-binding site
1204414007338	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1204414007339	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414007340	Walker A/P-loop; other site
1204414007341	ATP binding site [chemical binding]; other site
1204414007342	Q-loop/lid; other site
1204414007343	ABC transporter signature motif; other site
1204414007344	Walker B; other site
1204414007345	D-loop; other site
1204414007346	H-loop/switch region; other site
1204414007347	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1204414007348	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1204414007349	dimer interface [polypeptide binding]; other site
1204414007350	putative PBP binding regions; other site
1204414007351	ABC-ATPase subunit  interface; other site
1204414007352	Winged helix-turn helix; Region: HTH_29; pfam13551
1204414007353	Helix-turn-helix domain; Region: HTH_28; pfam13518
1204414007354	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1204414007355	Integrase core domain; Region: rve; pfam00665
1204414007356	Integrase core domain; Region: rve_3; pfam13683
1204414007357	hypothetical protein; Provisional; Region: PRK12839
1204414007358	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1204414007359	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1204414007360	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1204414007361	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1204414007362	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1204414007363	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414007364	putative substrate translocation pore; other site
1204414007365	metabolite-proton symporter; Region: 2A0106; TIGR00883
1204414007366	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1204414007367	Bacterial transcriptional regulator; Region: IclR; pfam01614
1204414007368	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1204414007369	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1204414007370	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1204414007371	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1204414007372	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1204414007373	active site
1204414007374	HIGH motif; other site
1204414007375	nucleotide binding site [chemical binding]; other site
1204414007376	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1204414007377	KMSKS motif; other site
1204414007378	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1204414007379	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1204414007380	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1204414007381	active site turn [active]
1204414007382	phosphorylation site [posttranslational modification]
1204414007383	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1204414007384	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1204414007385	HPr interaction site; other site
1204414007386	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1204414007387	active site
1204414007388	phosphorylation site [posttranslational modification]
1204414007389	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
1204414007390	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1204414007391	substrate binding [chemical binding]; other site
1204414007392	active site
1204414007393	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1204414007394	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1204414007395	active site
1204414007396	trimer interface [polypeptide binding]; other site
1204414007397	allosteric site; other site
1204414007398	active site lid [active]
1204414007399	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1204414007400	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1204414007401	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1204414007402	active site
1204414007403	dimer interface [polypeptide binding]; other site
1204414007404	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1204414007405	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1204414007406	inhibitor site; inhibition site
1204414007407	active site
1204414007408	dimer interface [polypeptide binding]; other site
1204414007409	catalytic residue [active]
1204414007410	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
1204414007411	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1204414007412	nucleotide binding site [chemical binding]; other site
1204414007413	Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
1204414007414	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
1204414007415	putative active site cavity [active]
1204414007416	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
1204414007417	catalytic site [active]
1204414007418	Asp-box motif; other site
1204414007419	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1204414007420	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1204414007421	DNA-binding site [nucleotide binding]; DNA binding site
1204414007422	FCD domain; Region: FCD; pfam07729
1204414007423	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1204414007424	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
1204414007425	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1204414007426	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1204414007427	dimer interface [polypeptide binding]; other site
1204414007428	conserved gate region; other site
1204414007429	putative PBP binding loops; other site
1204414007430	ABC-ATPase subunit interface; other site
1204414007431	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1204414007432	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1204414007433	Walker A/P-loop; other site
1204414007434	ATP binding site [chemical binding]; other site
1204414007435	Q-loop/lid; other site
1204414007436	ABC transporter signature motif; other site
1204414007437	Walker B; other site
1204414007438	D-loop; other site
1204414007439	H-loop/switch region; other site
1204414007440	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1204414007441	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1204414007442	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1204414007443	Walker A/P-loop; other site
1204414007444	ATP binding site [chemical binding]; other site
1204414007445	Q-loop/lid; other site
1204414007446	ABC transporter signature motif; other site
1204414007447	Walker B; other site
1204414007448	D-loop; other site
1204414007449	H-loop/switch region; other site
1204414007450	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1204414007451	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1204414007452	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1204414007453	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1204414007454	putative DNA binding site [nucleotide binding]; other site
1204414007455	putative Zn2+ binding site [ion binding]; other site
1204414007456	AsnC family; Region: AsnC_trans_reg; pfam01037
1204414007457	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1204414007458	homotrimer interaction site [polypeptide binding]; other site
1204414007459	zinc binding site [ion binding]; other site
1204414007460	CDP-binding sites; other site
1204414007461	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1204414007462	substrate binding site; other site
1204414007463	dimer interface; other site
1204414007464	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
1204414007465	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1204414007466	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1204414007467	active site
1204414007468	phosphorylation site [posttranslational modification]
1204414007469	intermolecular recognition site; other site
1204414007470	dimerization interface [polypeptide binding]; other site
1204414007471	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1204414007472	DNA binding site [nucleotide binding]
1204414007473	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1204414007474	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1204414007475	dimerization interface [polypeptide binding]; other site
1204414007476	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1204414007477	dimer interface [polypeptide binding]; other site
1204414007478	phosphorylation site [posttranslational modification]
1204414007479	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1204414007480	ATP binding site [chemical binding]; other site
1204414007481	Mg2+ binding site [ion binding]; other site
1204414007482	G-X-G motif; other site
1204414007483	DNA repair protein RadA; Provisional; Region: PRK11823
1204414007484	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1204414007485	Walker A motif; other site
1204414007486	ATP binding site [chemical binding]; other site
1204414007487	Walker B motif; other site
1204414007488	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1204414007489	Predicted nucleic-acid-binding protein (contains the HHH domain) [General function prediction only]; Region: COG1623
1204414007490	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1204414007491	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
1204414007492	NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151
1204414007493	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1204414007494	NAD(P) binding site [chemical binding]; other site
1204414007495	catalytic residues [active]
1204414007496	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
1204414007497	active site clefts [active]
1204414007498	zinc binding site [ion binding]; other site
1204414007499	dimer interface [polypeptide binding]; other site
1204414007500	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1204414007501	endonuclease III; Region: ENDO3c; smart00478
1204414007502	minor groove reading motif; other site
1204414007503	helix-hairpin-helix signature motif; other site
1204414007504	substrate binding pocket [chemical binding]; other site
1204414007505	active site
1204414007506	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
1204414007507	Mono-functional DNA-alkylating methyl methanesulfonate N-term; Region: MMS1_N; pfam10433
1204414007508	meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
1204414007509	acetoin reductases; Region: 23BDH; TIGR02415
1204414007510	NAD binding site [chemical binding]; other site
1204414007511	homotetramer interface [polypeptide binding]; other site
1204414007512	homodimer interface [polypeptide binding]; other site
1204414007513	active site
1204414007514	substrate binding site [chemical binding]; other site
1204414007515	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1204414007516	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1204414007517	Clp amino terminal domain; Region: Clp_N; pfam02861
1204414007518	Clp amino terminal domain; Region: Clp_N; pfam02861
1204414007519	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1204414007520	Walker A motif; other site
1204414007521	ATP binding site [chemical binding]; other site
1204414007522	Walker B motif; other site
1204414007523	arginine finger; other site
1204414007524	UvrB/uvrC motif; Region: UVR; pfam02151
1204414007525	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1204414007526	Walker A motif; other site
1204414007527	ATP binding site [chemical binding]; other site
1204414007528	Walker B motif; other site
1204414007529	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1204414007530	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807
1204414007531	IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516
1204414007532	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1204414007533	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1204414007534	active site
1204414007535	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1204414007536	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1204414007537	phenol 2-monooxygenase; Provisional; Region: PRK08294
1204414007538	FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979
1204414007539	dimer interface [polypeptide binding]; other site
1204414007540	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414007541	putative substrate translocation pore; other site
1204414007542	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1204414007543	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1204414007544	dimer interface [polypeptide binding]; other site
1204414007545	putative anticodon binding site; other site
1204414007546	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1204414007547	motif 1; other site
1204414007548	dimer interface [polypeptide binding]; other site
1204414007549	active site
1204414007550	motif 2; other site
1204414007551	motif 3; other site
1204414007552	Panthothenate synthetase [Coenzyme metabolism]; Region: PanC; COG0414
1204414007553	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1204414007554	active site
1204414007555	nucleotide binding site [chemical binding]; other site
1204414007556	HIGH motif; other site
1204414007557	KMSKS motif; other site
1204414007558	Rossmann-like domain; Region: Rossmann-like; pfam10727
1204414007559	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
1204414007560	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
1204414007561	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1204414007562	catalytic center binding site [active]
1204414007563	ATP binding site [chemical binding]; other site
1204414007564	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1204414007565	homooctamer interface [polypeptide binding]; other site
1204414007566	active site
1204414007567	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1204414007568	dihydropteroate synthase; Region: DHPS; TIGR01496
1204414007569	substrate binding pocket [chemical binding]; other site
1204414007570	dimer interface [polypeptide binding]; other site
1204414007571	inhibitor binding site; inhibition site
1204414007572	GTP cyclohydrolase I; Provisional; Region: PLN03044
1204414007573	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
1204414007574	homodecamer interface [polypeptide binding]; other site
1204414007575	active site
1204414007576	putative catalytic site residues [active]
1204414007577	zinc binding site [ion binding]; other site
1204414007578	GTP-CH-I/GFRP interaction surface; other site
1204414007579	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1204414007580	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1204414007581	Walker A motif; other site
1204414007582	ATP binding site [chemical binding]; other site
1204414007583	Walker B motif; other site
1204414007584	arginine finger; other site
1204414007585	Peptidase family M41; Region: Peptidase_M41; pfam01434
1204414007586	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1204414007587	active site
1204414007588	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1204414007589	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1204414007590	Ligand Binding Site [chemical binding]; other site
1204414007591	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
1204414007592	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
1204414007593	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
1204414007594	dimer interface [polypeptide binding]; other site
1204414007595	substrate binding site [chemical binding]; other site
1204414007596	metal binding sites [ion binding]; metal-binding site
1204414007597	Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262
1204414007598	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1204414007599	S-adenosylmethionine binding site [chemical binding]; other site
1204414007600	Predicted membrane protein [Function unknown]; Region: COG3766
1204414007601	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
1204414007602	Domain of unknown function (DUF4247); Region: DUF4247; pfam14042
1204414007603	Protein of unknown function DUF2617; Region: DUF2617; pfam10936
1204414007604	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
1204414007605	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1204414007606	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl17885
1204414007607	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
1204414007608	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1204414007609	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1204414007610	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1204414007611	active site residue [active]
1204414007612	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1204414007613	MarR family; Region: MarR_2; pfam12802
1204414007614	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1204414007615	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1204414007616	acyl-activating enzyme (AAE) consensus motif; other site
1204414007617	AMP binding site [chemical binding]; other site
1204414007618	active site
1204414007619	CoA binding site [chemical binding]; other site
1204414007620	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1204414007621	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
1204414007622	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1204414007623	putative CoA binding site [chemical binding]; other site
1204414007624	putative trimer interface [polypeptide binding]; other site
1204414007625	Protein of unknown function (DUF3754); Region: DUF3754; pfam12576
1204414007626	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1204414007627	putative trimer interface [polypeptide binding]; other site
1204414007628	putative CoA binding site [chemical binding]; other site
1204414007629	succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407
1204414007630	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101
1204414007631	NAD(P) binding site [chemical binding]; other site
1204414007632	catalytic residues [active]
1204414007633	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
1204414007634	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1204414007635	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1204414007636	ring oligomerisation interface [polypeptide binding]; other site
1204414007637	ATP/Mg binding site [chemical binding]; other site
1204414007638	stacking interactions; other site
1204414007639	hinge regions; other site
1204414007640	Tubulin like; Region: Tubulin_2; pfam13809
1204414007641	von Willebrand factor (vWF) type A domain; Region: VWA; smart00327
1204414007642	metal ion-dependent adhesion site (MIDAS); other site
1204414007643	hypothetical protein; Provisional; Region: PRK07907
1204414007644	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
1204414007645	active site
1204414007646	metal binding site [ion binding]; metal-binding site
1204414007647	dimer interface [polypeptide binding]; other site
1204414007648	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
1204414007649	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644
1204414007650	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1204414007651	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
1204414007652	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
1204414007653	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946
1204414007654	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665
1204414007655	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1204414007656	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
1204414007657	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948
1204414007658	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12592
1204414007659	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1204414007660	carboxylate-amine ligase; Provisional; Region: PRK13517
1204414007661	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
1204414007662	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
1204414007663	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
1204414007664	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1204414007665	active site
1204414007666	catalytic residues [active]
1204414007667	metal binding site [ion binding]; metal-binding site
1204414007668	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1204414007669	Coenzyme A binding pocket [chemical binding]; other site
1204414007670	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
1204414007671	putative catalytic site [active]
1204414007672	putative phosphate binding site [ion binding]; other site
1204414007673	active site
1204414007674	metal binding site A [ion binding]; metal-binding site
1204414007675	DNA binding site [nucleotide binding]
1204414007676	putative AP binding site [nucleotide binding]; other site
1204414007677	putative metal binding site B [ion binding]; other site
1204414007678	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
1204414007679	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1204414007680	putative active site [active]
1204414007681	catalytic site [active]
1204414007682	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1204414007683	putative active site [active]
1204414007684	catalytic site [active]
1204414007685	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
1204414007686	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414007687	putative substrate translocation pore; other site
1204414007688	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
1204414007689	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1204414007690	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1204414007691	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1204414007692	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
1204414007693	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1204414007694	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1204414007695	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414007696	Walker A/P-loop; other site
1204414007697	ATP binding site [chemical binding]; other site
1204414007698	Q-loop/lid; other site
1204414007699	ABC transporter signature motif; other site
1204414007700	Walker B; other site
1204414007701	D-loop; other site
1204414007702	H-loop/switch region; other site
1204414007703	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1204414007704	nudix motif; other site
1204414007705	CHASE3 domain; Region: CHASE3; cl05000
1204414007706	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1204414007707	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1204414007708	substrate binding pocket [chemical binding]; other site
1204414007709	membrane-bound complex binding site; other site
1204414007710	hinge residues; other site
1204414007711	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1204414007712	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1204414007713	active site
1204414007714	ATP binding site [chemical binding]; other site
1204414007715	substrate binding site [chemical binding]; other site
1204414007716	activation loop (A-loop); other site
1204414007717	propionate/acetate kinase; Provisional; Region: PRK12379
1204414007718	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1204414007719	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
1204414007720	ferredoxin-NADP+ reductase; Region: PLN02852
1204414007721	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1204414007722	Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153
1204414007723	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
1204414007724	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1204414007725	ATP-grasp domain; Region: ATP-grasp; pfam02222
1204414007726	putative transposase OrfB; Reviewed; Region: PHA02517
1204414007727	HTH-like domain; Region: HTH_21; pfam13276
1204414007728	Integrase core domain; Region: rve; pfam00665
1204414007729	Integrase core domain; Region: rve_3; pfam13683
1204414007730	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1204414007731	Transposase; Region: HTH_Tnp_1; pfam01527
1204414007732	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1204414007733	Histidine kinase; Region: HisKA_3; pfam07730
1204414007734	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1204414007735	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1204414007736	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1204414007737	active site
1204414007738	phosphorylation site [posttranslational modification]
1204414007739	intermolecular recognition site; other site
1204414007740	dimerization interface [polypeptide binding]; other site
1204414007741	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
1204414007742	DNA binding residues [nucleotide binding]
1204414007743	dimerization interface [polypeptide binding]; other site
1204414007744	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1204414007745	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1204414007746	GDP-binding site [chemical binding]; other site
1204414007747	ACT binding site; other site
1204414007748	IMP binding site; other site
1204414007749	cardiolipin synthetase; Reviewed; Region: PRK12452
1204414007750	Predicted membrane protein [Function unknown]; Region: COG4129
1204414007751	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1204414007752	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1204414007753	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
1204414007754	active site
1204414007755	intersubunit interface [polypeptide binding]; other site
1204414007756	zinc binding site [ion binding]; other site
1204414007757	Na+ binding site [ion binding]; other site
1204414007758	Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833
1204414007759	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1204414007760	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
1204414007761	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1204414007762	active site
1204414007763	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1204414007764	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1204414007765	active site residue [active]
1204414007766	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1204414007767	active site residue [active]
1204414007768	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1204414007769	sequence-specific DNA binding site [nucleotide binding]; other site
1204414007770	salt bridge; other site
1204414007771	H+ Antiporter protein; Region: 2A0121; TIGR00900
1204414007772	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414007773	putative substrate translocation pore; other site
1204414007774	Domain of unknown function (DUF4265); Region: DUF4265; pfam14085
1204414007775	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1204414007776	Clp amino terminal domain; Region: Clp_N; pfam02861
1204414007777	Clp amino terminal domain; Region: Clp_N; pfam02861
1204414007778	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1204414007779	Walker A motif; other site
1204414007780	ATP binding site [chemical binding]; other site
1204414007781	Walker B motif; other site
1204414007782	arginine finger; other site
1204414007783	Protein of unknown function (DUF2730); Region: DUF2730; pfam10805
1204414007784	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1204414007785	Walker A motif; other site
1204414007786	ATP binding site [chemical binding]; other site
1204414007787	Walker B motif; other site
1204414007788	arginine finger; other site
1204414007789	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1204414007790	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
1204414007791	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1204414007792	putative DNA binding site [nucleotide binding]; other site
1204414007793	dimerization interface [polypeptide binding]; other site
1204414007794	putative Zn2+ binding site [ion binding]; other site
1204414007795	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1204414007796	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
1204414007797	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1204414007798	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1204414007799	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1204414007800	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
1204414007801	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1204414007802	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
1204414007803	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1204414007804	homodimer interface [polypeptide binding]; other site
1204414007805	substrate-cofactor binding pocket; other site
1204414007806	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1204414007807	catalytic residue [active]
1204414007808	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1204414007809	non-specific DNA binding site [nucleotide binding]; other site
1204414007810	salt bridge; other site
1204414007811	sequence-specific DNA binding site [nucleotide binding]; other site
1204414007812	Cupin domain; Region: Cupin_2; pfam07883
1204414007813	Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120
1204414007814	Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120
1204414007815	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861
1204414007816	Firmicute plasmid replication protein (RepL); Region: RepL; pfam05732
1204414007817	Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952
1204414007818	Predicted nucleotidyltransferase [General function prediction    only]; Region: COG4849
1204414007819	2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543
1204414007820	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
1204414007821	FAD binding pocket [chemical binding]; other site
1204414007822	conserved FAD binding motif [chemical binding]; other site
1204414007823	phosphate binding motif [ion binding]; other site
1204414007824	beta-alpha-beta structure motif; other site
1204414007825	NAD binding pocket [chemical binding]; other site
1204414007826	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1204414007827	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
1204414007828	putative active site [active]
1204414007829	catalytic triad [active]
1204414007830	putative dimer interface [polypeptide binding]; other site
1204414007831	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
1204414007832	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1204414007833	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1204414007834	NAD(P) binding site [chemical binding]; other site
1204414007835	catalytic residues [active]
1204414007836	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
1204414007837	DNA binding residues [nucleotide binding]
1204414007838	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1204414007839	putative dimer interface [polypeptide binding]; other site
1204414007840	chaperone protein DnaJ; Provisional; Region: PRK14279
1204414007841	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1204414007842	HSP70 interaction site [polypeptide binding]; other site
1204414007843	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1204414007844	Zn binding sites [ion binding]; other site
1204414007845	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1204414007846	dimer interface [polypeptide binding]; other site
1204414007847	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
1204414007848	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1204414007849	dimer interface [polypeptide binding]; other site
1204414007850	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1204414007851	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1204414007852	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
1204414007853	nucleotide binding site [chemical binding]; other site
1204414007854	NEF interaction site [polypeptide binding]; other site
1204414007855	SBD interface [polypeptide binding]; other site
1204414007856	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1204414007857	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1204414007858	nucleosidase; Provisional; Region: PRK05634
1204414007859	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
1204414007860	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924
1204414007861	Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795
1204414007862	Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983
1204414007863	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
1204414007864	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
1204414007865	Walker A/P-loop; other site
1204414007866	ATP binding site [chemical binding]; other site
1204414007867	Q-loop/lid; other site
1204414007868	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
1204414007869	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
1204414007870	Protein of unknown function (DUF3375); Region: DUF3375; pfam11855
1204414007871	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1204414007872	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
1204414007873	NAD binding site [chemical binding]; other site
1204414007874	substrate binding site [chemical binding]; other site
1204414007875	catalytic Zn binding site [ion binding]; other site
1204414007876	tetramer interface [polypeptide binding]; other site
1204414007877	structural Zn binding site [ion binding]; other site
1204414007878	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1204414007879	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
1204414007880	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1204414007881	putative active site [active]
1204414007882	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
1204414007883	active site
1204414007884	sulfate adenylyltransferase, large subunit; Region: CysN; TIGR02034
1204414007885	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
1204414007886	CysD dimerization site [polypeptide binding]; other site
1204414007887	G1 box; other site
1204414007888	putative GEF interaction site [polypeptide binding]; other site
1204414007889	GTP/Mg2+ binding site [chemical binding]; other site
1204414007890	Switch I region; other site
1204414007891	G2 box; other site
1204414007892	G3 box; other site
1204414007893	Switch II region; other site
1204414007894	G4 box; other site
1204414007895	G5 box; other site
1204414007896	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
1204414007897	Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G.  Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786
1204414007898	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
1204414007899	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1204414007900	Active Sites [active]
1204414007901	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
1204414007902	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1204414007903	Active Sites [active]
1204414007904	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
1204414007905	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1204414007906	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1204414007907	ferredoxin-NADP+ reductase; Region: PLN02852
1204414007908	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1204414007909	Fic family protein [Function unknown]; Region: COG3177
1204414007910	Fic/DOC family; Region: Fic; pfam02661
1204414007911	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
1204414007912	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1204414007913	dimer interface [polypeptide binding]; other site
1204414007914	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1204414007915	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
1204414007916	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
1204414007917	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
1204414007918	Predicted ATPase [General function prediction only]; Region: COG3910
1204414007919	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
1204414007920	Walker A/P-loop; other site
1204414007921	ATP binding site [chemical binding]; other site
1204414007922	Q-loop/lid; other site
1204414007923	ABC transporter signature motif; other site
1204414007924	Walker B; other site
1204414007925	D-loop; other site
1204414007926	H-loop/switch region; other site
1204414007927	Predicted ATPase [General function prediction only]; Region: COG3910
1204414007928	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
1204414007929	Walker A/P-loop; other site
1204414007930	ATP binding site [chemical binding]; other site
1204414007931	Q-loop/lid; other site
1204414007932	ABC transporter signature motif; other site
1204414007933	Walker B; other site
1204414007934	D-loop; other site
1204414007935	H-loop/switch region; other site
1204414007936	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414007937	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1204414007938	putative substrate translocation pore; other site
1204414007939	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
1204414007940	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
1204414007941	putative metal binding site [ion binding]; other site
1204414007942	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
1204414007943	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1204414007944	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414007945	ABC transporter signature motif; other site
1204414007946	Walker B; other site
1204414007947	D-loop; other site
1204414007948	H-loop/switch region; other site
1204414007949	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
1204414007950	Walker A/P-loop; other site
1204414007951	ATP binding site [chemical binding]; other site
1204414007952	ABC transporter signature motif; other site
1204414007953	Walker B; other site
1204414007954	D-loop; other site
1204414007955	H-loop/switch region; other site
1204414007956	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1204414007957	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
1204414007958	dimer interface [polypeptide binding]; other site
1204414007959	FMN binding site [chemical binding]; other site
1204414007960	NADPH bind site [chemical binding]; other site
1204414007961	Inosine-uridine nucleoside N-ribohydrolase [Nucleotide transport and metabolism]; Region: URH1; COG1957
1204414007962	active site
1204414007963	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1204414007964	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
1204414007965	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
1204414007966	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1204414007967	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
1204414007968	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1204414007969	heme-binding site [chemical binding]; other site
1204414007970	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
1204414007971	FAD binding pocket [chemical binding]; other site
1204414007972	FAD binding motif [chemical binding]; other site
1204414007973	phosphate binding motif [ion binding]; other site
1204414007974	beta-alpha-beta structure motif; other site
1204414007975	NAD binding pocket [chemical binding]; other site
1204414007976	Heme binding  pocket [chemical binding]; other site
1204414007977	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
1204414007978	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
1204414007979	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
1204414007980	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1204414007981	PRD domain; Region: PRD; pfam00874
1204414007982	PRD domain; Region: PRD; pfam00874
1204414007983	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1204414007984	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1204414007985	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1204414007986	H-loop/switch region; other site
1204414007987	aminotransferase AlaT; Validated; Region: PRK09265
1204414007988	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1204414007989	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1204414007990	homodimer interface [polypeptide binding]; other site
1204414007991	catalytic residue [active]
1204414007992	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1204414007993	Helix-turn-helix domain; Region: HTH_38; pfam13936
1204414007994	Homeodomain-like domain; Region: HTH_32; pfam13565
1204414007995	Integrase core domain; Region: rve; pfam00665
1204414007996	Predicted multitransmembrane protein [Function unknown]; Region: COG5438
1204414007997	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1204414007998	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1204414007999	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1204414008000	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1204414008001	trimer interface [polypeptide binding]; other site
1204414008002	active site
1204414008003	Htaa; Region: HtaA; pfam04213
1204414008004	Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720
1204414008005	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
1204414008006	VanW like protein; Region: VanW; pfam04294
1204414008007	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1204414008008	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
1204414008009	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1204414008010	Ligand Binding Site [chemical binding]; other site
1204414008011	Protein of unknown function (DUF2613); Region: DUF2613; pfam11021
1204414008012	Domain of unknown function (DUF3367); Region: DUF3367; pfam11847
1204414008013	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1204414008014	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
1204414008015	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1204414008016	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1204414008017	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1204414008018	S-adenosylmethionine binding site [chemical binding]; other site
1204414008019	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
1204414008020	active site
1204414008021	substrate-binding site [chemical binding]; other site
1204414008022	metal-binding site [ion binding]
1204414008023	GTP binding site [chemical binding]; other site
1204414008024	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
1204414008025	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320
1204414008026	gating phenylalanine in ion channel; other site
1204414008027	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1204414008028	S-adenosylmethionine binding site [chemical binding]; other site
1204414008029	LabA_like proteins; Region: LabA_like; cd06167
1204414008030	putative metal binding site [ion binding]; other site
1204414008031	MMPL family; Region: MMPL; pfam03176
1204414008032	MMPL family; Region: MMPL; pfam03176
1204414008033	Predicted integral membrane protein [Function unknown]; Region: COG0392
1204414008034	Protein of unknown function (DUF3054); Region: DUF3054; pfam11255
1204414008035	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1204414008036	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1204414008037	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1204414008038	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1204414008039	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1204414008040	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1204414008041	active site
1204414008042	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1204414008043	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1204414008044	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1204414008045	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769
1204414008046	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1204414008047	acyl-activating enzyme (AAE) consensus motif; other site
1204414008048	active site
1204414008049	Cutinase; Region: Cutinase; pfam01083
1204414008050	Putative esterase; Region: Esterase; pfam00756
1204414008051	S-formylglutathione hydrolase; Region: PLN02442
1204414008052	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
1204414008053	LGFP repeat; Region: LGFP; pfam08310
1204414008054	LGFP repeat; Region: LGFP; pfam08310
1204414008055	LGFP repeat; Region: LGFP; pfam08310
1204414008056	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1204414008057	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1204414008058	active site
1204414008059	Putative esterase; Region: Esterase; pfam00756
1204414008060	S-formylglutathione hydrolase; Region: PLN02442
1204414008061	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
1204414008062	UbiA prenyltransferase family; Region: UbiA; pfam01040
1204414008063	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1204414008064	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
1204414008065	active site
1204414008066	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1204414008067	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1204414008068	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1204414008069	active site
1204414008070	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1204414008071	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1204414008072	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1204414008073	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
1204414008074	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1204414008075	UDP-galactopyranose mutase; Region: GLF; pfam03275
1204414008076	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
1204414008077	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1204414008078	amidase catalytic site [active]
1204414008079	Zn binding residues [ion binding]; other site
1204414008080	substrate binding site [chemical binding]; other site
1204414008081	LGFP repeat; Region: LGFP; pfam08310
1204414008082	glycerol kinase; Provisional; Region: glpK; PRK00047
1204414008083	Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789
1204414008084	N- and C-terminal domain interface [polypeptide binding]; other site
1204414008085	active site
1204414008086	MgATP binding site [chemical binding]; other site
1204414008087	catalytic site [active]
1204414008088	metal binding site [ion binding]; metal-binding site
1204414008089	putative homotetramer interface [polypeptide binding]; other site
1204414008090	glycerol binding site [chemical binding]; other site
1204414008091	homodimer interface [polypeptide binding]; other site
1204414008092	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1204414008093	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1204414008094	active site
1204414008095	motif I; other site
1204414008096	motif II; other site
1204414008097	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1204414008098	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1204414008099	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1204414008100	putative acyl-acceptor binding pocket; other site
1204414008101	seryl-tRNA synthetase; Provisional; Region: PRK05431
1204414008102	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1204414008103	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1204414008104	dimer interface [polypeptide binding]; other site
1204414008105	active site
1204414008106	motif 1; other site
1204414008107	motif 2; other site
1204414008108	motif 3; other site
1204414008109	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1204414008110	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1204414008111	DNA-binding site [nucleotide binding]; DNA binding site
1204414008112	UTRA domain; Region: UTRA; pfam07702
1204414008113	Septum formation; Region: Septum_form; pfam13845
1204414008114	Septum formation; Region: Septum_form; pfam13845
1204414008115	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
1204414008116	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1204414008117	catalytic core [active]
1204414008118	prephenate dehydratase; Provisional; Region: PRK11898
1204414008119	Prephenate dehydratase; Region: PDT; pfam00800
1204414008120	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1204414008121	putative L-Phe binding site [chemical binding]; other site
1204414008122	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1204414008123	Amidase; Region: Amidase; cl11426
1204414008124	CAAX protease self-immunity; Region: Abi; pfam02517
1204414008125	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1204414008126	Protein of unknown function (DUF3500); Region: DUF3500; pfam12006
1204414008127	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1204414008128	Protein of unknown function (DUF3500); Region: DUF3500; pfam12006
1204414008129	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1204414008130	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582
1204414008131	putative active site [active]
1204414008132	catalytic site [active]
1204414008133	putative metal binding site [ion binding]; other site
1204414008134	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
1204414008135	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1204414008136	pyruvate kinase; Provisional; Region: PRK14725
1204414008137	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
1204414008138	active site
1204414008139	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1204414008140	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1204414008141	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1204414008142	NAD binding site [chemical binding]; other site
1204414008143	dimer interface [polypeptide binding]; other site
1204414008144	substrate binding site [chemical binding]; other site
1204414008145	Predicted membrane protein [Function unknown]; Region: COG4425
1204414008146	Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081
1204414008147	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1204414008148	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1204414008149	motif II; other site
1204414008150	Predicted flavoprotein [General function prediction only]; Region: COG0431
1204414008151	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1204414008152	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1204414008153	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1204414008154	DNA-binding site [nucleotide binding]; DNA binding site
1204414008155	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1204414008156	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1204414008157	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1204414008158	active site
1204414008159	metal binding site [ion binding]; metal-binding site
1204414008160	metabolite-proton symporter; Region: 2A0106; TIGR00883
1204414008161	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414008162	putative substrate translocation pore; other site
1204414008163	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
1204414008164	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
1204414008165	active site
1204414008166	substrate binding site [chemical binding]; other site
1204414008167	FMN binding site [chemical binding]; other site
1204414008168	putative catalytic residues [active]
1204414008169	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1204414008170	non-specific DNA binding site [nucleotide binding]; other site
1204414008171	salt bridge; other site
1204414008172	sequence-specific DNA binding site [nucleotide binding]; other site
1204414008173	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1204414008174	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1204414008175	Uncharacterized conserved protein [Function unknown]; Region: COG4894
1204414008176	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1204414008177	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1204414008178	metal binding site [ion binding]; metal-binding site
1204414008179	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1204414008180	methionine sulfoxide reductase A; Provisional; Region: PRK00058
1204414008181	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1204414008182	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1204414008183	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1204414008184	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1204414008185	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1204414008186	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
1204414008187	putative dimerization interface [polypeptide binding]; other site
1204414008188	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414008189	putative substrate translocation pore; other site
1204414008190	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1204414008191	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
1204414008192	Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251
1204414008193	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
1204414008194	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414008195	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1204414008196	putative substrate translocation pore; other site
1204414008197	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1204414008198	MarR family; Region: MarR_2; pfam12802
1204414008199	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1204414008200	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1204414008201	active site
1204414008202	phosphorylation site [posttranslational modification]
1204414008203	intermolecular recognition site; other site
1204414008204	dimerization interface [polypeptide binding]; other site
1204414008205	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1204414008206	DNA binding residues [nucleotide binding]
1204414008207	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1204414008208	Histidine kinase; Region: HisKA_3; pfam07730
1204414008209	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1204414008210	ATP binding site [chemical binding]; other site
1204414008211	Mg2+ binding site [ion binding]; other site
1204414008212	G-X-G motif; other site
1204414008213	Domain of unknown function (DUF2020); Region: DUF2020; pfam09449
1204414008214	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830
1204414008215	active site
1204414008216	catalytic site [active]
1204414008217	putative inner membrane protein translocase component YidC; Validated; Region: PRK00247
1204414008218	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
1204414008219	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1204414008220	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1204414008221	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
1204414008222	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1204414008223	Ligand Binding Site [chemical binding]; other site
1204414008224	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1204414008225	Ligand Binding Site [chemical binding]; other site
1204414008226	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1204414008227	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1204414008228	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1204414008229	Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558
1204414008230	probable active site [active]
1204414008231	Predicted transcriptional regulators [Transcription]; Region: COG1725
1204414008232	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1204414008233	DNA-binding site [nucleotide binding]; DNA binding site
1204414008234	LabA_like proteins; Region: LabA_like; cd06167
1204414008235	putative metal binding site [ion binding]; other site
1204414008236	Uncharacterized conserved protein [Function unknown]; Region: COG1432
1204414008237	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
1204414008238	Integrase core domain; Region: rve; pfam00665
1204414008239	Integrase core domain; Region: rve_3; pfam13683
1204414008240	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
1204414008241	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1204414008242	metal coordination site [ion binding]; other site
1204414008243	Helix-turn-helix domain; Region: HTH_28; pfam13518
1204414008244	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1204414008245	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1204414008246	S-adenosylmethionine binding site [chemical binding]; other site
1204414008247	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
1204414008248	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
1204414008249	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1204414008250	Ferredoxin [Energy production and conversion]; Region: COG1146
1204414008251	4Fe-4S binding domain; Region: Fer4; pfam00037
1204414008252	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1204414008253	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544
1204414008254	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
1204414008255	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1204414008256	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1204414008257	motif I; other site
1204414008258	motif II; other site
1204414008259	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1204414008260	metal-binding site [ion binding]
1204414008261	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1204414008262	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1204414008263	dimerization interface [polypeptide binding]; other site
1204414008264	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1204414008265	dimer interface [polypeptide binding]; other site
1204414008266	phosphorylation site [posttranslational modification]
1204414008267	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1204414008268	ATP binding site [chemical binding]; other site
1204414008269	Mg2+ binding site [ion binding]; other site
1204414008270	G-X-G motif; other site
1204414008271	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1204414008272	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1204414008273	active site
1204414008274	phosphorylation site [posttranslational modification]
1204414008275	intermolecular recognition site; other site
1204414008276	dimerization interface [polypeptide binding]; other site
1204414008277	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1204414008278	DNA binding site [nucleotide binding]
1204414008279	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
1204414008280	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1204414008281	Multicopper oxidase; Region: Cu-oxidase; pfam00394
1204414008282	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1204414008283	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1204414008284	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1204414008285	catalytic residues [active]
1204414008286	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1204414008287	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1204414008288	putative NAD(P) binding site [chemical binding]; other site
1204414008289	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1204414008290	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1204414008291	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1204414008292	metal-binding site [ion binding]
1204414008293	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
1204414008294	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1204414008295	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1204414008296	DDE domain; Region: DDE_Tnp_IS240; pfam13610
1204414008297	DDE domain; Region: DDE_Tnp_IS240; pfam13610
1204414008298	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1204414008299	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1204414008300	catalytic residues [active]
1204414008301	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1204414008302	metal-binding site [ion binding]
1204414008303	benzoate transport; Region: 2A0115; TIGR00895
1204414008304	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414008305	putative substrate translocation pore; other site
1204414008306	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414008307	Predicted transcriptional regulators [Transcription]; Region: COG1695
1204414008308	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1204414008309	replicative DNA helicase; Provisional; Region: PRK05636
1204414008310	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1204414008311	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1204414008312	Walker A motif; other site
1204414008313	ATP binding site [chemical binding]; other site
1204414008314	Walker B motif; other site
1204414008315	DNA binding loops [nucleotide binding]
1204414008316	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1204414008317	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1204414008318	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1204414008319	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1204414008320	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1204414008321	dimer interface [polypeptide binding]; other site
1204414008322	ssDNA binding site [nucleotide binding]; other site
1204414008323	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1204414008324	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1204414008325	Predicted integral membrane protein [Function unknown]; Region: COG5650
1204414008326	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1204414008327	Transglycosylase; Region: Transgly; pfam00912
1204414008328	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1204414008329	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1204414008330	MarR family; Region: MarR; pfam01047
1204414008331	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1204414008332	Ligand Binding Site [chemical binding]; other site
1204414008333	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1204414008334	Ligand Binding Site [chemical binding]; other site
1204414008335	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1204414008336	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
1204414008337	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
1204414008338	active site residue [active]
1204414008339	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1204414008340	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1204414008341	FtsX-like permease family; Region: FtsX; pfam02687
1204414008342	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1204414008343	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1204414008344	Walker A/P-loop; other site
1204414008345	ATP binding site [chemical binding]; other site
1204414008346	Q-loop/lid; other site
1204414008347	ABC transporter signature motif; other site
1204414008348	Walker B; other site
1204414008349	D-loop; other site
1204414008350	H-loop/switch region; other site
1204414008351	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1204414008352	HlyD family secretion protein; Region: HlyD_3; pfam13437
1204414008353	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
1204414008354	inositol 1-phosphate synthase, Actinobacterial type; Region: mycothiol_INO1; TIGR03450
1204414008355	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
1204414008356	hypothetical protein; Provisional; Region: PRK13663
1204414008357	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1204414008358	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1204414008359	dimerization interface [polypeptide binding]; other site
1204414008360	DPS ferroxidase diiron center [ion binding]; other site
1204414008361	ion pore; other site
1204414008362	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
1204414008363	N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970
1204414008364	putative DNA binding site [nucleotide binding]; other site
1204414008365	catalytic residue [active]
1204414008366	putative H2TH interface [polypeptide binding]; other site
1204414008367	putative catalytic residues [active]
1204414008368	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1204414008369	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
1204414008370	hypothetical protein; Reviewed; Region: PRK09588
1204414008371	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1204414008372	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1204414008373	putative active site [active]
1204414008374	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1204414008375	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1204414008376	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1204414008377	DNA binding site [nucleotide binding]
1204414008378	active site
1204414008379	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
1204414008380	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
1204414008381	putative NAD(P) binding site [chemical binding]; other site
1204414008382	dimer interface [polypeptide binding]; other site
1204414008383	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1204414008384	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414008385	putative substrate translocation pore; other site
1204414008386	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
1204414008387	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1204414008388	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1204414008389	putative NAD(P) binding site [chemical binding]; other site
1204414008390	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
1204414008391	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
1204414008392	N- and C-terminal domain interface [polypeptide binding]; other site
1204414008393	active site
1204414008394	catalytic site [active]
1204414008395	metal binding site [ion binding]; metal-binding site
1204414008396	carbohydrate binding site [chemical binding]; other site
1204414008397	ATP binding site [chemical binding]; other site
1204414008398	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
1204414008399	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
1204414008400	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1204414008401	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
1204414008402	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1204414008403	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1204414008404	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1204414008405	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1204414008406	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1204414008407	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
1204414008408	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1204414008409	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
1204414008410	putative FMN binding site [chemical binding]; other site
1204414008411	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1204414008412	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1204414008413	HIGH motif; other site
1204414008414	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1204414008415	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1204414008416	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1204414008417	active site
1204414008418	KMSKS motif; other site
1204414008419	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1204414008420	tRNA binding surface [nucleotide binding]; other site
1204414008421	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
1204414008422	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
1204414008423	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1204414008424	non-specific DNA binding site [nucleotide binding]; other site
1204414008425	salt bridge; other site
1204414008426	sequence-specific DNA binding site [nucleotide binding]; other site
1204414008427	mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583
1204414008428	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
1204414008429	MDMPI C-terminal domain; Region: MDMPI_C; pfam07398
1204414008430	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1204414008431	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1204414008432	Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435
1204414008433	Cupin domain; Region: Cupin_2; pfam07883
1204414008434	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
1204414008435	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1204414008436	Bacterial transcriptional regulator; Region: IclR; pfam01614
1204414008437	Baculoviral E56 protein, specific to ODV envelope; Region: Baculo_E56; pfam04639
1204414008438	benzoate transport; Region: 2A0115; TIGR00895
1204414008439	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414008440	putative substrate translocation pore; other site
1204414008441	salicylate hydroxylase; Provisional; Region: PRK08163
1204414008442	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1204414008443	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1204414008444	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
1204414008445	SdpI/YhfL protein family; Region: SdpI; pfam13630
1204414008446	Predicted integral membrane protein [Function unknown]; Region: COG5658
1204414008447	anthranilate synthase component I; Provisional; Region: PRK13564
1204414008448	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1204414008449	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1204414008450	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1204414008451	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1204414008452	glutamine binding [chemical binding]; other site
1204414008453	catalytic triad [active]
1204414008454	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1204414008455	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1204414008456	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1204414008457	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
1204414008458	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1204414008459	active site
1204414008460	ribulose/triose binding site [chemical binding]; other site
1204414008461	phosphate binding site [ion binding]; other site
1204414008462	substrate (anthranilate) binding pocket [chemical binding]; other site
1204414008463	product (indole) binding pocket [chemical binding]; other site
1204414008464	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1204414008465	active site
1204414008466	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1204414008467	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1204414008468	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1204414008469	catalytic residue [active]
1204414008470	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
1204414008471	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1204414008472	substrate binding site [chemical binding]; other site
1204414008473	active site
1204414008474	catalytic residues [active]
1204414008475	heterodimer interface [polypeptide binding]; other site
1204414008476	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
1204414008477	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1204414008478	active site
1204414008479	phosphorylation site [posttranslational modification]
1204414008480	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
1204414008481	active site
1204414008482	P-loop; other site
1204414008483	phosphorylation site [posttranslational modification]
1204414008484	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1204414008485	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1204414008486	Walker A/P-loop; other site
1204414008487	ATP binding site [chemical binding]; other site
1204414008488	Q-loop/lid; other site
1204414008489	ABC transporter signature motif; other site
1204414008490	Walker B; other site
1204414008491	D-loop; other site
1204414008492	H-loop/switch region; other site
1204414008493	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
1204414008494	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
1204414008495	iron-sulfur cluster [ion binding]; other site
1204414008496	[2Fe-2S] cluster binding site [ion binding]; other site
1204414008497	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1204414008498	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
1204414008499	active site
1204414008500	FMN binding site [chemical binding]; other site
1204414008501	substrate binding site [chemical binding]; other site
1204414008502	homotetramer interface [polypeptide binding]; other site
1204414008503	catalytic residue [active]
1204414008504	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1204414008505	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
1204414008506	Uncharacterized conserved protein [Function unknown]; Region: COG3358
1204414008507	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1204414008508	putative DNA binding site [nucleotide binding]; other site
1204414008509	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1204414008510	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
1204414008511	active site
1204414008512	FMN binding site [chemical binding]; other site
1204414008513	substrate binding site [chemical binding]; other site
1204414008514	homotetramer interface [polypeptide binding]; other site
1204414008515	catalytic residue [active]
1204414008516	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
1204414008517	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1204414008518	NAD(P) binding site [chemical binding]; other site
1204414008519	putative active site [active]
1204414008520	short chain dehydrogenase; Provisional; Region: PRK08267
1204414008521	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1204414008522	NAD(P) binding site [chemical binding]; other site
1204414008523	active site
1204414008524	mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416
1204414008525	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
1204414008526	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1204414008527	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414008528	putative substrate translocation pore; other site
1204414008529	POT family; Region: PTR2; cl17359
1204414008530	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1204414008531	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
1204414008532	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
1204414008533	active site
1204414008534	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1204414008535	Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177
1204414008536	active site
1204414008537	dimer interface [polypeptide binding]; other site
1204414008538	metal binding site [ion binding]; metal-binding site
1204414008539	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
1204414008540	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414008541	putative substrate translocation pore; other site
1204414008542	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414008543	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1204414008544	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1204414008545	Bacterial transcriptional regulator; Region: IclR; pfam01614
1204414008546	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1204414008547	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1204414008548	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1204414008549	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1204414008550	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1204414008551	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1204414008552	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1204414008553	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1204414008554	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1204414008555	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1204414008556	Lamin Tail Domain; Region: LTD; pfam00932
1204414008557	Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750
1204414008558	Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399
1204414008559	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1204414008560	putative active site [active]
1204414008561	putative metal binding site [ion binding]; other site
1204414008562	proline/glycine betaine transporter; Provisional; Region: PRK10642
1204414008563	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414008564	putative substrate translocation pore; other site
1204414008565	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
1204414008566	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1204414008567	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719
1204414008568	GIY-YIG motif/motif A; other site
1204414008569	active site
1204414008570	catalytic site [active]
1204414008571	metal binding site [ion binding]; metal-binding site
1204414008572	Predicted helicase [General function prediction only]; Region: COG4889
1204414008573	Restriction endonuclease; Region: Mrr_cat_2; pfam13156
1204414008574	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1204414008575	ATP binding site [chemical binding]; other site
1204414008576	putative Mg++ binding site [ion binding]; other site
1204414008577	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1204414008578	ATP-binding site [chemical binding]; other site
1204414008579	Domain of unknown function (DUF4395); Region: DUF4395; pfam14340
1204414008580	Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [Coenzyme metabolism]; Region: ThiD; COG0351
1204414008581	ATP binding site [chemical binding]; other site
1204414008582	substrate binding site [chemical binding]; other site
1204414008583	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1204414008584	DNA binding site [nucleotide binding]
1204414008585	active site
1204414008586	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1204414008587	metal-binding site [ion binding]
1204414008588	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1204414008589	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
1204414008590	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1204414008591	siderophore binding site; other site
1204414008592	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1204414008593	2-enoyl thioester reductase (ETR) like proteins, child 2; Region: ETR_like_2; cd08292
1204414008594	putative NAD(P) binding site [chemical binding]; other site
1204414008595	putative dimer interface [polypeptide binding]; other site
1204414008596	Predicted membrane protein [Function unknown]; Region: COG3759
1204414008597	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1204414008598	substrate binding site [chemical binding]; other site
1204414008599	dimer interface [polypeptide binding]; other site
1204414008600	ATP binding site [chemical binding]; other site
1204414008601	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
1204414008602	metal-binding site [ion binding]
1204414008603	Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687
1204414008604	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
1204414008605	hypothetical protein; Validated; Region: PRK00228
1204414008606	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
1204414008607	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1204414008608	active site
1204414008609	NTP binding site [chemical binding]; other site
1204414008610	metal binding triad [ion binding]; metal-binding site
1204414008611	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1204414008612	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1204414008613	Zn2+ binding site [ion binding]; other site
1204414008614	Mg2+ binding site [ion binding]; other site
1204414008615	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
1204414008616	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
1204414008617	active site
1204414008618	Ap6A binding site [chemical binding]; other site
1204414008619	nudix motif; other site
1204414008620	metal binding site [ion binding]; metal-binding site
1204414008621	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
1204414008622	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
1204414008623	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1204414008624	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1204414008625	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1204414008626	DNA binding residues [nucleotide binding]
1204414008627	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1204414008628	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1204414008629	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1204414008630	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1204414008631	catalytic residues [active]
1204414008632	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1204414008633	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1204414008634	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1204414008635	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1204414008636	active site
1204414008637	metal binding site [ion binding]; metal-binding site
1204414008638	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1204414008639	ParB-like nuclease domain; Region: ParB; smart00470
1204414008640	KorB domain; Region: KorB; pfam08535
1204414008641	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1204414008642	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1204414008643	P-loop; other site
1204414008644	Magnesium ion binding site [ion binding]; other site
1204414008645	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1204414008646	Magnesium ion binding site [ion binding]; other site
1204414008647	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1204414008648	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1204414008649	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
1204414008650	putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449
1204414008651	ribonuclease P; Reviewed; Region: rnpA; PRK03459