-- dump date 20140619_051440 -- class Genbank::CDS -- table cds_note -- id note NP_599253.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. NP_599254.1 binds the polymerase to DNA and acts as a sliding clamp NP_599255.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA NP_599257.1 negatively supercoils closed circular double-stranded DNA NP_599258.1 member of alpha/beta hydrolase superfamily NP_599264.1 negatively supercoils closed circular double-stranded DNA NP_599265.1 similar to permeases of the major facilitator superfamily NP_599267.1 similar to lysR family bacterial regulatory helix-turn-helix protein NP_599269.1 similar to cytochrome C biogenesis protein transmembrane region NP_599276.2 OsmC-like protein; predicted redox protein; regulator of disulfide bond formation NP_599277.1 contains an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen NP_599279.1 periplasmic solute binding protein family; ABC-type Mn/Zn transport system; periplasmic Mn/Zn-binding (lipo)protein; surface adhesin A NP_599280.1 ABC 3 transport family; ABC-type Mn2+/Zn2+ transport system NP_599281.1 type II (General) secretory pathway (IISP) family protein; similar to ABC transporter-ATP binding proteins and heme exporter protein CcmA NP_599282.2 similar to periplasmic binding proteins NP_599283.1 similar to ribose/xylose/arabinose/galactoside ABC-type transport systems permeases NP_599284.1 similar to type II (general) secretory pathway (IISP) family proteins and heme exporter protein CcmA NP_599286.1 member of the cyclophilin family NP_599287.1 similar to Drosophila rhomboid NP_599288.1 similar to araC family bacterial regulatory helix-turn-helix proteins NP_599289.1 similar to ABC-type cobalamin/Fe3+-siderophores transport systems permeases NP_599290.1 similar to ABC-type cobalamin/Fe3+-siderophores transport systems, ATPases; yype II (general) secretory pathway (IISP) family protein NP_599292.1 integral membrane protein involved in inhibition of the Z-ring formation NP_599295.1 penicillin-binding protein 2 NP_599297.1 similar to protein phosphatase 2C NP_599303.2 catalyzes the formation of catechol from phenol NP_599304.1 similar to glyoxylases and metallo-beta-lactamase superfamily NP_599310.1 contains preprotein translocase subunit SecA (ATPase, RNA helicase) domain NP_599313.1 CorA-like transporter protein NP_599314.1 similar to taut NP_599315.1 contains voltage gated chloride channel domain NP_599320.1 similar to signal transduction histidine kinase regulating citrate/malate metabolism NP_599321.1 consisting of a CheY-like receiver domain and a HTH DNA-binding domain NP_599322.1 similar to D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NP_599324.1 catalyzes the formation of biotin from dethiobiotin and sulfur 2 S-adenosyl-L-methionine NP_599326.1 member of major facilitator superfamily; member of drug resistance transporter EmrB/QacA subfamily NP_599332.1 contains the alpha/beta hydrolase fold NP_599333.1 contains the alpha/beta hydrolase fold NP_599336.1 UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter NP_599337.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta) NP_599338.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits NP_599339.1 involved in the assembly of the urease metallocenter; possible nickel donor NP_599341.1 involved in regulation of expression and maturation of urease and hydrogenase NP_599343.1 member of alpha/beta hydrolase superfamily NP_599344.1 member of major facilitator superfamily NP_599345.1 contains glycerol 3-phosphate dehydrogenase domain NP_599347.1 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile NP_599349.2 contains thiamine pyrophosphate enzyme, N-terminal TPP binding domain; similar to acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase and phosphonopyruvate decarboxylase NP_599351.1 similar to NAD-dependent aldehyde dehydrogenases NP_599352.1 related to aryl-alcohol dehydrogenases NP_599354.1 similar to amidases, aminoacylases and carboxypeptidases NP_599363.1 member of major facilitator superfamily NP_599366.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine NP_599367.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate NP_694632.1 responsible for recognizing base lesions in the genome and initiating base excision DNA repair NP_599372.1 similar to haloacid dehalogenase-like hydrolase NP_599373.1 member of the isoleucine patch superfamily; contains bacterial transferase hexapeptide (four repeats) NP_599375.1 similar to H+ antiporter protein NP_599381.1 probably involved in cell wall biogenesis NP_599385.1 similar to RarD protein NP_599388.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5) NP_599394.2 contains helicase conserved C-terminal domain NP_599395.1 member of the isoleucine patch superfamily; contains bacterial transferase hexapeptide (four repeats) NP_599401.1 contains 6-O-methylguanine DNA methyltransferase DNA binding domain NP_599406.1 member of peptidase M13 NP_599409.1 similar to the gntR family bacterial regulatory proteins NP_599413.1 similar to uncharacterized enzyme involved in inositol metabolism NP_599414.1 similar to acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase and phosphonopyruvate decarboxylase NP_599415.1 similar to sugar phosphate isomerases/epimerases NP_599430.1 similar to acetyltransferase (GNAT) family NP_599437.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate NP_599442.1 similar to short-chain alcohol dehydrogenase NP_599453.1 similar to ABC-type polysaccharide/polyol phosphate transport system, ATPase; type II (general) secretory pathway (IISP) family protein NP_599454.1 similar to ABC-type polysaccharide/polyol phosphate export systems, permease NP_599458.1 similar to flavodoxin reductase 1 (ferredoxin-NADPH reductases) NP_599461.1 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase NP_599464.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis NP_599477.1 contains CBS domain NP_599479.1 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate NP_599481.1 contains cytidine and deoxycytidylate deaminase zinc-binding region NP_599489.1 this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu NP_599491.2 contains integrase core domain NP_599493.1 similar to transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs NP_599495.2 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA NP_599497.1 involved in a recombinational process of DNA repair, independent of the recBC complex NP_599499.1 contains Mur ligase, catalytic domain NP_599500.1 3'-5' exonuclease of DNA polymerase III NP_599503.2 similar to permeases of the drug/metabolite transporter (DMT) superfamily NP_599504.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation. NP_599505.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde NP_599507.1 Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription NP_599510.2 member of AsnC family NP_599511.1 azaleucine resistance protein AzlC NP_599514.1 arsR family bacterial regulatory protein NP_599517.1 subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport NP_599518.1 subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali NP_599519.1 subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali NP_599520.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone NP_599521.1 subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali NP_599522.1 subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali NP_599525.1 contains a CheY-like receiver domain and a HTH DNA-binding domain NP_599530.1 contains GatB/Yqey domain NP_599531.1 penicillin-binding protein NP_599532.1 similar to transcription factor WhiB NP_599537.1 member of the MarR family NP_599538.1 similar to short-chain alcohol dehydrogenases NP_599542.1 member of the metallo-beta-lactamase superfamily, including glyoxylases NP_599543.1 catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase NP_599547.1 similar to oxidative damage repair enzymes; contains MutT-like domain NP_599548.1 typically periplasmic; contain C-terminal PDZ domain NP_599549.1 member of alpha/beta hydrolase superfamily NP_599554.2 member of the VirB11 family; bacterial type II or IV secretion system protein NP_599559.1 distinct helicase with a unique C-terminal domain including a metal-binding cysteine cluster NP_599561.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity NP_599563.1 contains HAMP domain NP_599564.2 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA NP_599573.2 similar to short-chain alcohol dehydrogenases NP_599591.1 member of the peptidase S9A NP_599599.1 involved in regulation of cell wall biogenesis NP_599612.1 member of the isoleucine patch superfamily NP_599614.1 E3 component of alpha keto acid dehydrogenase complexes LpdC; forms a homodimer; binds one molecule of FAD monomer; catalyzes NAD+-dependent oxidation of dihydrolipoyl cofactors that are covalently linked to the E2 component NP_599617.1 contains helix-turn-helix NP_599619.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol NP_599620.1 catalyzes the reversible formation of fumarate and ubiquinol from succinate and ubiquinone NP_599622.1 similar to ABC-type cobalamin/Fe3+-siderophores transport systems, periplasmic components NP_599626.1 similar to permeases of the major facilitator superfamily NP_599627.1 similar to the tetR family of bacterial regulatory proteins NP_599630.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine NP_599631.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate NP_599637.1 ABC-type cobalamin/Fe3+-siderophores transport systems, periplasmic components NP_599638.1 similar to FecCD transport family proteins and ABC-type cobalamin/Fe3+-siderophores transport systems, permeases NP_599639.1 similar to ABC-type cobalamin/Fe3+-siderophores transport systems, ATPases NP_599645.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis NP_599647.1 activates fatty acids by binding to coenzyme A NP_599648.1 similar to group I glycosyl transferases NP_599649.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate NP_599651.1 contains a CheY-like receiver domain and a HTH DNA-binding domain NP_599653.1 involved in lipoprotein release NP_599658.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate NP_599663.1 contains thiol-disulfide isomerase and thioredoxin domain NP_599664.2 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins NP_599665.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis NP_599667.1 lysR family bacterial regulatory helix-turn-helix protein NP_599670.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis NP_599671.1 catalyzes the NAD-dependent formation of 3-dehydroquinate and 3-dehydroshikimate from quinate and shikimate; oxidation of quinate is about 3 times more efficient NP_599674.1 similar to ABC-type iron/thiamine transport system permease NP_599675.1 similar to ABC-type iron/thiamine transport system permease NP_599678.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate NP_599682.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III NP_599683.1 catalyzes the formation of protoporphyrin IX from protoporphyrinogen IX NP_599684.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway NP_599685.1 member of the phosphoglycerate mutase NP_599687.1 transmembrane region NP_599689.1 ABC-type transport system involved in cytochrome C biogenesis, permease NP_599692.1 bacterial regulatory protein NP_599695.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate NP_599700.1 catalyzes the formation of 2,5-dioxopentanoate from 5-dehydro-4-deoxy-D-glucarate NP_599701.1 similar to bacterial regulatory helix-turn-helix protein NP_599708.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA NP_599711.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate NP_599712.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis NP_599716.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone NP_599719.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force NP_599720.1 Modulates Rho-dependent transcription termination NP_599721.1 binds directly to 23S ribosomal RNA NP_599722.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA NP_599724.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate NP_599730.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit NP_599731.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors NP_599733.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme NP_599734.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter NP_599738.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance NP_599739.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit NP_599740.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene NP_599741.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu NP_599743.1 similar to ABC-type cobalamin/Fe3+-siderophore transport system NP_599744.1 FecCD transport family; similar to ABC-type cobalamin/Fe3+-siderophore transport system NP_599745.1 FecCD transport family; similar to ABC-type cobalamin/Fe3+-siderophore transport system NP_599747.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex NP_599748.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin NP_599749.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA NP_599750.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel NP_599751.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation NP_599752.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA NP_599753.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center NP_599754.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation NP_599755.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e NP_599756.1 one of the stabilizing components for the large ribosomal subunit NP_599757.1 primary binding protein; helps mediate assembly; involved in translation fidelity NP_599760.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase NP_599761.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel NP_599762.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 NP_599764.1 similar to diketogulonate reductase NP_599766.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth NP_599768.2 selenocysteine-containing anaerobic dehydrogenase; similar to Molybdopterin oxidoreductase NP_599771.1 duplicated NP_599772.1 similar to CbiQ and related transporters NP_599773.1 similar to dihydrolipoamide dehydrogenase/glutathione oxidoreductase and related enzymes NP_599775.1 member of acetyltransferase (GNAT) family; similar to histone acetyltransferase HPA2 NP_599776.2 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit NP_599777.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance NP_599778.1 binds 5S rRNA along with protein L5 and L25 NP_599779.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance NP_599780.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 NP_599781.1 late assembly protein NP_599787.1 contains Fe-2S iron-sulfur cluster binding domain NP_599788.1 related to short-chain alcohol dehydrogenases NP_599789.1 contains PEP-utilizing enzyme, mobile domain NP_599790.1 contains pyruvate phosphate dikinase, PEP/pyruvate binding domain NP_599793.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase NP_599794.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP NP_599795.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn NP_599797.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 NP_599798.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA NP_599799.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 NP_599800.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination NP_599801.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme NP_599802.1 is a component of the macrolide binding site in the peptidyl transferase center NP_599803.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability NP_599805.1 member of the acetyltransferase (GNAT) family NP_599808.1 contains FAD binding domain NP_599811.1 member of the subtilase NP_599817.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit NP_599818.1 forms a direct contact with the tRNA during translation NP_599819.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate NP_599824.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer NP_599827.1 member of the alpha/beta hydrolase superfamily NP_599828.1 similar to molecular chaperones NP_599829.1 member of the acetyltransferase (GNAT) family NP_599830.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity NP_599831.1 similar to sugar kinases NP_599833.2 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring NP_599834.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is not essential for growth NP_599835.1 similar to transcription factor WhiB NP_599836.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this protein is involved in expression of ribosome-associated gene products in stationary phase NP_599839.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate NP_599840.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate NP_599841.1 similar to permease of the drug/metabolite transporter (DMT) superfamily NP_599842.1 member of lysR family of bacterial regulatory helix-turn-helix proteins NP_599843.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway NP_599845.1 similar to stress-responsive transcriptional regulator NP_599847.1 contains a CheY-like receiver domain and a HTH DNA-binding domain; similar to luxR family regulatory proteins NP_599852.1 similar to nucleotidyltransferase/DNA polymerase involved in DNA repair NP_599855.1 UbiA prenyltransferase catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones, hemes, chlorophylls, vitamin E, and shikonin NP_599861.2 similar to polyprenyl synthetase NP_599868.1 involved in lipoprotein release NP_599869.1 binding-protein-dependent transport systems inner membrane component NP_599871.1 similar to YaeC family lipoprotein NP_599872.1 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis. It is not the major replicative DNA polymerase. NP_599877.1 Modulates the activities of several enzymes which are inactive in their acetylated form NP_599878.1 contains cytidine and deoxycytidylate deaminase zinc-binding region NP_599879.1 periplasmic binding protein NP_599881.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate NP_599885.1 Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine NP_599886.1 catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol NP_599891.1 catalyzes the formation of citrate from acetyl-CoA and oxaloacetate NP_599894.1 member of the gntR family NP_599897.1 similar to siderophore-interacting proteins NP_599898.1 similar to ABC-type cobalamin/Fe3+-siderophores transport systems NP_599899.1 similar to ABC-type cobalamin/Fe3+-siderophores transport systems NP_599900.1 similar to ABC-type cobalamin/Fe3+-siderophores transport systems NP_599901.1 similar to ABC-type cobalamin/Fe3+-siderophores transport systems NP_599906.1 similar to ABC-type cobalamin/Fe3+-siderophores transport systems NP_599907.1 similar to ABC-type cobalamin/Fe3+-siderophores transport systems NP_599908.1 similar to ABC-type cobalamin/Fe3+-siderophores transport systems NP_599909.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_599910.1 similar to tRNA-processing ribonuclease BN NP_599914.1 similar to cell wall-associated hydrolases and invasion-associated proteins NP_599916.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate NP_599917.1 contains helix-turn-helix NP_599920.1 catalyzes the reduction of nonspecific electron acceptors such as 2,6-dimethyl-1,4-benzoquinone and 5-hydroxy-1,4-naphthaquinone; does not have lipoamide dehydrogenase activity NP_599921.1 biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate NP_599922.1 contains thioredoxin domain NP_599923.1 contains SCP/PR1 domains NP_599926.1 involved in propionate catabolism NP_599928.1 catalyzes the formation of citrate from acetyl-CoA and oxaloacetate NP_599930.1 contains helix-turn-helix NP_599933.1 contains rhodanese-like domain NP_599937.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell NP_599939.1 similar to acetyl-CoA carboxylase beta subunit NP_599940.1 similar to acetyl-CoA carboxylase alpha subunit NP_599941.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon NP_599943.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway NP_599946.1 Catalyzes a step in the de novo purine nucleotide biosynthetic pathway NP_599949.1 similar to coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases NP_599950.1 contains integrase core domain NP_599951.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis NP_599952.1 similar to dihydrofolate reductase NP_599953.1 similar to lactoylglutathione lyase and related lyases NP_599955.1 similar to sugar permeases NP_599958.1 contains sugar-binding periplasmic domains NP_599962.1 contains unique C-terminal domain including a metal-binding cysteine cluster NP_599966.1 member of superfamily I DNA and RNA helicases NP_599967.1 contains unique C-terminal domain including a metal-binding cysteine cluster NP_599969.1 member of the superfamily II DNA/RNA helicases NP_599972.1 involved in lipopolysaccharide biosynthesis/translation initiation factor eIF2B subunits NP_599973.1 similar to transcriptional regulators NP_599976.1 converts mannose-6-phosphate to mannose-1-phosphate; the resulting product is then converted to GDP-mannose by ManC which is then used in the synthesis of mannose-containing glycoconjugates that are important for mediating entry into host cells NP_599981.1 catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine NP_599982.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) NP_599983.1 contains a CheY-like receiver domain and a HTH DNA-binding domain NP_694638.1 similar to competence protein F NP_599986.1 PSrp-1 NP_599987.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins NP_599989.1 similar to hydrolases of the HAD superfamily NP_599991.1 similar to predicted GTPases NP_599992.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis NP_599995.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response NP_599996.1 similar to transcription factor WhiB NP_599999.2 member of superfamily II DNA and RNA helicases NP_600003.1 member of superfamily I DNA and RNA helicases NP_600004.1 member of superfamily I DNA and RNA helicases NP_600006.1 containing a Zn-finger; probably nucleic-acid-binding NP_600007.1 member of superfamily I DNA and RNA helicases NP_600009.1 similar to metal-dependent hydrolase NP_600011.1 contains a PDZ domain NP_600015.1 contains a DNA-binding HTH domain, an MocR family aminotransferase domain, and their eukaryotic orthologs NP_600016.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate NP_600017.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate NP_600028.1 similar to enzymes of inositol monophosphatase NP_600029.1 similar to enzymes of inositol monophosphatase NP_600030.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1 NP_600033.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation NP_694640.1 limited similarity to transposases NP_600045.1 member of the DNA or RNA helicases of superfamily II NP_600049.1 contains cold-shock DNA-binding domain NP_600052.1 similar to branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase NP_600057.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate NP_600058.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH NP_600065.1 similar to 3-oxoacyl-(acyl-carrier-protein) synthase NP_600068.1 catalyzes the formation of O-acetyl -L-homoserine from L-homoserine and acetyl-CoA NP_600071.1 similar to glutaredoxin NP_600073.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived NP_600074.1 similar to 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase NP_600078.1 similar to permeases NP_600080.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family NP_600083.1 member of superfamily I DNA and RNA helicases NP_600084.1 involved in lipoprotein release NP_600085.1 involved in lipoprotein release NP_600089.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate NP_600090.1 involved in de novo purine biosynthesis NP_600092.1 similar to repressor of the high-affinity (methyl) ammonium uptake system NP_600094.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit NP_600095.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif NP_600096.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif NP_600097.1 required for 70S ribosome assembly NP_600098.1 member of the MFS superfamily NP_600099.1 similar to arsR family NP_600100.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome NP_600101.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not NP_600102.1 contains a CheY-like receiver domain and a HTH DNA-binding domain NP_600104.1 contains C-terminal PDZ domain, typically periplasmic NP_600111.1 similar to N-acetylases of ribosomal proteins NP_600120.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content NP_600121.1 member of the superfamily II DNA helicases NP_600122.1 similar to metal-dependent hydrolases NP_600123.1 contains double-stranded beta-helix domain NP_600124.1 similar to lipases and esterases NP_600126.2 similar to transposase NP_600127.2 similar to transposase NP_600128.2 similar to transposase NP_600129.1 component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent NP_600132.2 similar to transposases NP_600133.1 similar to transposases; contains integrase core domain NP_600135.1 similar to cadmium resistance transporter NP_600138.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin NP_600139.1 catalyzes the phosphorylation of 4-diphosphocytidyl-2-C-methyl-D-erythritol in the nonmevalonate pathway of isoprenoid biosynthesis NP_600140.1 contains duplicated ATPase NP_600142.1 similar to thiol-disulfide isomerase and thioredoxins NP_600146.2 similar to predicted hydrolases of the HAD superfamily NP_600147.1 catalyzes the formation of 3-hydroxy-2-methylpropanoate from 3-hydroxy-2-methylpropanoyl-CoA NP_600150.1 similar to esterase NP_600151.2 similar to the tetR family NP_600153.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity NP_600157.1 GTPase NP_600158.1 similar to ABC-type branched-chain amino acid transport systems NP_600159.1 similar to ABC-type branched-chain amino acid transport systems NP_600160.1 similar to ABC-type branched-chain amino acid transport systems NP_600161.1 similar to ABC-type branched-chain amino acid transport systems NP_600162.1 similar to ABC-type branched-chain amino acid transport systems NP_600163.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation NP_600164.1 similar to 2-nitropropane dioxygenase NP_600165.1 catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; involved in growth under gluconeogenic conditions and in glycolytic activity at high ATP concentrations in Corynebacterium; NAD and NADP dependent NP_600166.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation NP_600167.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response NP_600170.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP NP_600171.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis NP_600172.1 similar to permeases of the major facilitator superfamily NP_600174.1 similar to ABC-type multidrug transport system NP_600175.1 similar to ABC-type multidrug transport system NP_600177.1 contains a CheY-like receiver domain and a HTH DNA-binding domain NP_600179.1 similar to multitransmembrane proteins NP_600180.1 similar to ABC-type multidrug/protein/lipid transport system NP_600181.1 similar to ABC-type multidrug/protein/lipid transport system NP_600185.1 contains integrase core domain NP_600189.1 similar to tetR family regulatory proteins NP_600191.1 similar to ABC-type multidrug/protein/lipid transport system NP_600192.1 similar to ABC-type multidrug/protein/lipid transport system NP_600194.1 similar to esterases NP_600195.1 similar to L-lysine transport protein NP_600197.1 similar to predicted pyrophosphatase MazG NP_600201.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis NP_600205.1 catalyzes the formation of 2-oxobutanoate from L-threonine NP_600208.1 riboflavin biosynthesis NP_600211.1 similar to permeases of the major facilitator superfamily NP_600213.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus NP_600215.2 LmbE-like protein NP_600216.1 similar to ribosomal protein S2 NP_600217.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive NP_600218.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate NP_600220.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis NP_600221.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate NP_600223.1 similar to branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase NP_600225.1 similar to transcriptional regulator NP_600229.1 similar to lactam utilization protein B NP_600230.1 similar to Na+/proline, Na+/panthothenate symporters and related permeases NP_600233.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle NP_600234.1 associated with flavoprotein oxygenases; DIM6/NTAB family NP_600237.1 similar to predicted flavoprotein and reductases NP_600238.1 similar to coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases NP_600241.1 similar to related flavin-dependent oxidoreductases NP_600242.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese NP_600245.1 similar to arabinose efflux permease NP_600247.1 catalyzes the bidirectional exonucleolytic cleavage of DNA NP_600248.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides NP_600249.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway NP_600250.1 similar to gamma-aminobutyrate permease and related permeases NP_600251.1 similar to predicted permease NP_600254.1 similar to esterase NP_600255.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 NP_600259.1 similar to N-acetylases of ribosomal proteins NP_600260.1 related to short-chain alcohol dehydrogenases NP_600263.1 contains diguanylate cyclase/phosphodiesterase domain 2 (EAL) NP_600264.1 similar to glycosyltransferases involved in cell wall biogenesis NP_600266.1 similar to predicted dinucleotide-utilizing enzyme NP_600273.1 related to diketogulonate reductase NP_600274.1 similar to gamma-carboxymuconolactone decarboxylase subunit NP_600277.2 related transporters (MFS superfamily) NP_600289.1 contains duplicated ATPase domains NP_600291.1 Zn-ribbon-containing protein involved in phosphonate metabolism NP_600295.1 similar to cysteine desulfurase and related enzymes NP_600296.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide NP_600297.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate NP_600300.1 similar to predicted Zn-dependent hydrolases of the beta-lactamase fold NP_600305.1 catalyzes the formation of protocatechuate from 4-hydroxybenzoate NP_600306.1 similar to ABC transporter permease NP_600307.1 similar to ABC-type cobalt transport system NP_600308.1 similar to ABC-type cobalt transport system NP_600311.2 similar to LmbE NP_600314.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein NP_600317.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis NP_600321.1 similar to Trypsin-like serine proteases; typically periplasmic; contain C-terminal PDZ domain NP_600322.1 glutaredoxin family member NP_600327.2 similar to dipeptide/oligopeptide/nickel transport systems NP_600328.1 similar to LmbE NP_600331.1 catalyzes the formation of N-succinyl-LL-2,6-diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis NP_600335.2 similar to related permeases or aromatic amino acid permease NP_600337.1 catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate NP_600340.2 involved in cell wall biogenesis NP_600344.1 levanase/invertase NP_600345.2 glycosyl transferases group 1 NP_600346.3 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate NP_600348.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein is involved in heat shock, oxidative stress and virulence NP_600350.1 similar to Sec-independent protein secretion pathway components NP_600351.1 involved in chromosome partitioning NP_600353.1 contains CBS domain NP_600357.3 kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth NP_600358.1 similar to ABC-type multidrug/protein/lipid transport systems NP_600360.1 catalyzes the conversion of shikimate to 3-dehydroshikimate NP_600367.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine NP_600372.1 similar to acyltransferases (alpha/beta hydrolase superfamily) NP_600374.1 similar to ABC-type multidrug/protein/lipid transport system NP_600375.1 similar to ABC-type multidrug/protein/lipid transport system NP_600378.1 DNA or RNA helicases of superfamily II NP_600379.1 similar to NTP pyrophosphohydrolases including oxidative damage repair enzymes NP_600382.1 similar to superfamily II DNA and RNA helicases NP_600384.1 catalyzes the formation of 3-(2,3-dihydroxyphenyl)propionate from 3-(3-hydroxyphenyl)propionate NP_600390.1 similar to superfamily II DNA/RNA helicases; SNF2 family NP_600398.1 similar to stress-responsive transcriptional regulator NP_600400.1 similar to regulatory subunit of cAMP-dependent protein kinases; contains cAMP-binding domains NP_600404.1 similar to alpha/beta hydrolase superfamily NP_600405.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase NP_600409.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine NP_600410.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate NP_600415.1 typically selenocysteine-containing NP_600418.1 similar to subtilisin-like serine proteases NP_600419.1 similar to hemolysins and related proteins containing CBS domains NP_600420.1 similar to hemolysins and related proteins containing CBS domains NP_600423.2 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z NP_600424.1 activates fatty acids by binding to coenzyme A NP_600425.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes NP_600426.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 NP_600429.1 UDP-N- acetylglucosamine-1-phosphate transferase NP_600431.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 NP_600432.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 NP_600433.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. NP_600434.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex NP_600435.2 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit NP_600436.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit NP_600437.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit NP_600438.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane NP_600444.1 similar to related flavin-dependent oxidoreductases NP_600445.1 similar to ABC-type nitrate/sulfonate/taurine/bicarbonate transport systems NP_600446.1 similar to ABC-type nitrate/sulfonate/taurine/bicarbonate transport systems NP_600447.1 similar to ABC-type nitrate/sulfonate/taurine/bicarbonate transport systems NP_600448.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain NP_600450.1 similar to ABC-type molybdenum transport systems NP_600452.1 similar to SAM-dependent methyltransferases NP_600455.1 similar to cysteine desulfurase and related enzymes NP_600463.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs NP_600466.1 3'-5' exonuclease of DNA polymerase III NP_600467.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB NP_600469.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain NP_600470.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA NP_600473.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis NP_600475.1 similar to ABC-type sugar (aldose) transport systems NP_600476.1 similar to ribose/xylose/arabinose/galactoside ABC-type transport systems NP_600478.1 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source NP_600479.1 similar to N-acetylases of ribosomal proteins NP_600480.1 similar to ABC-type cobalamin/Fe3+-siderophores transport systems NP_600482.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA NP_600484.1 related to aryl-alcohol dehydrogenases NP_600486.1 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport NP_600490.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis NP_600493.1 acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate NP_600494.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit NP_600495.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis NP_600498.1 similar to ABC-type nitrate/sulfonate/taurine/bicarbonate transport systems NP_600500.1 similar to acyl-CoA dehydrogenases NP_600501.1 similar to acyl-CoA dehydrogenases NP_600502.1 contains conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family NP_600506.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate NP_600508.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis NP_600509.1 similar to ABC-type nitrate/sulfonate/taurine/bicarbonate transport systems NP_600510.1 contains cAMP-binding and CBS domains NP_600511.1 similar to related 3'-5' exonucleases NP_600514.1 synthesizes isochorismate acid from chorismate NP_600515.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation NP_600527.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine NP_600531.1 similar to glyoxylases NP_600536.1 dehydratase, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate NP_600537.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D NP_600538.1 similar to oxidative damage repair enzymes NP_600540.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate NP_600541.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli NP_600543.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP NP_600544.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine NP_600545.2 related to dihydroxyacetone kinase NP_600549.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA NP_600569.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair NP_600572.1 related to diketogulonate reductase NP_600575.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins NP_600576.1 PTS enzyme II; involved in mannose, glucose, and glucosamine transport NP_600577.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis NP_600587.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion NP_600588.1 related to nucleotide-binding proteins NP_600591.1 similar to superfamily I DNA and RNA helicases NP_600592.1 similar to methyl-accepting chemotaxis protein NP_600593.1 similar to Zn-dependent hydrolases, including glyoxylases NP_600595.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate NP_600597.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits NP_600599.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit NP_600602.2 similar to ABC-type sugar transport systems NP_600603.1 similar to ABC-type sugar transport systems NP_600604.1 similar to ABC-type sugar transport systems NP_600605.1 similar to ABC-type sugar transport systems NP_600608.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily NP_600609.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily NP_600613.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate NP_600614.1 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate NP_600615.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate NP_600616.1 catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine NP_600617.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation NP_600618.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes NP_600619.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming NP_600620.1 catalyzes the formation of arginine from (N-L-arginino)succinate NP_600622.1 similar to Mg-chelatase subunit ChlD NP_600625.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) NP_600626.1 similar to nucleotide-binding proteins NP_600631.1 catalyzes the phosphorylation of NAD to NADP NP_600635.1 CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer NP_600636.1 similar to oxidative damage repair enzymes; PF00293:MutT-like domain; TIGR00052:TIGR00052: conserved hypothetical protein TIGR00052 NP_600637.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs NP_600641.1 similar to N-acetylases of ribosomal proteins NP_600643.1 contains the HTH domain NP_600644.1 similar to pseudouridylate synthases NP_600645.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP NP_600646.1 synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains NP_600648.1 similar to DNA gyrase inhibitor NP_600650.1 similar to multidrug/protein/lipid transport system NP_600651.1 similar to multidrug/protein/lipid transport system NP_600657.1 SecA2; functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond to SecA2; which is non-essential and seems to play a role in secretion of a subset of proteins NP_600665.1 similar to hemolysins NP_600666.1 similar to hemolysins NP_600667.1 similar to superfamily II DNA and RNA helicases NP_600669.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate NP_600670.1 possibly involved in aromatic compounds catabolism NP_600672.1 similar to multidrug transport system NP_600673.1 similar to multidrug transport system NP_600675.1 ABC-type phosphate/phosphonate transport system NP_600676.1 ABC-type phosphate/phosphonate transport system NP_600677.1 ABC-type phosphate/phosphonate transport system NP_600678.1 similar to phosphate/phosphonate-binding protein NP_600680.3 catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate NP_600681.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP NP_600683.1 similar to methyltransferases NP_600687.1 similar to related permeases NP_600690.1 similar to related transporters (MFS superfamily) NP_600695.1 similar to membrane GTPase LepA NP_600696.1 involved in cell wall biogenesis NP_600698.1 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein NP_600700.1 similar to NAD-dependent aldehyde dehydrogenases NP_600702.1 probable dehydrogenase NP_600704.1 similar to trypsin-like serine proteases; typically periplasmic; contain C-terminal PDZ domain NP_600705.1 similar to superfamily II DNA and RNA helicases NP_600707.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes NP_600715.1 catalyzes the removal of amino acids from the N termini of peptides NP_600719.1 catalyzes the formation of fumarate from aspartate NP_600720.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors NP_600721.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis NP_600726.2 similar to related permeases NP_600730.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA NP_600731.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell NP_600732.2 related to aryl-alcohol dehydrogenases NP_600734.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors NP_600740.1 similar to ABC-type multidrug/protein/lipid transport system NP_600741.1 similar to ABC-type multidrug/protein/lipid transport system NP_600743.1 functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins NP_600744.1 MDM; functions in conversion of succinate to propionate NP_600747.1 similar to ATP-dependent Lon protease, bacterial type NP_600748.1 similar to stomatin/prohibitin-like proteins NP_600749.1 implicated in regulation of membrane protease activity NP_600751.1 excinuclease ATPase subunit NP_600752.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic NP_600753.1 invasion-associated proteins; similar to methyl-accepting chemotaxis protein NP_600755.1 Catalyzes the conversion of citrate to isocitrate NP_600757.1 Catalyzes the transfer of the ammonia group from glutamine to a new carbon-nitrogen group NP_600758.1 COG0702:predicted nucleoside-diphosphate-sugar epimerases NP_600760.1 ACT domain-containing protein NP_600763.1 similar to signal recognition particle GTPase NP_600772.1 contains integrase core domain NP_600774.1 similar to predicted metal-sulfur cluster biosynthetic enzyme NP_600775.1 involved in Fe-S cluster formation NP_600776.1 aminotransferase class-V NP_600777.1 similar to iron-regulated ABC transporter ATPase subunit SufC NP_600782.1 similar to ABC-type multidrug transport system NP_600783.1 similar to ABC-type multidrug transport system NP_600785.1 similar to DNA or RNA helicases of superfamily II NP_600786.1 similar to related Zn-dependent oxidoreductases and zinc-binding dehydrogenases NP_600787.1 converts protoheme IX and farnesyl diphosphate to heme O NP_600788.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase NP_600789.1 catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate NP_600790.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate NP_600791.1 stimulates glucose-6-P dehydrogenase activity NP_600792.1 catalyzes the formation of 6-phospho-D-gluconate from 6-phospho-D-glucono-1,5-lactone NP_600793.1 similar to lycine/D-amino acid oxidases (deaminating) NP_600795.1 deaminating; similar to sarcosine oxidase NP_600796.1 catalyzes the formation of L-proline from L-ornithine NP_600798.1 similar to SecG subunit NP_600799.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate NP_600800.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate NP_600801.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway NP_600802.1 catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate NP_600806.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision NP_600808.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not NP_600809.1 bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate NP_600810.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine NP_600811.1 riboflavin biosynthesis NP_600812.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate NP_600814.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth NP_600815.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) NP_600816.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity NP_600817.1 methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase NP_600818.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine NP_600819.1 Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits NP_600820.2 Essential for recycling GMP and indirectly, cGMP NP_600822.1 OMP decarboxylase; OMPDCase; OMPdecase; type 2 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase NP_600823.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity NP_600824.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers NP_600825.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis NP_600826.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis NP_600827.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity NP_600832.1 Regulates rRNA biosynthesis by transcriptional antitermination NP_600833.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA NP_600835.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis NP_600836.1 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis NP_600837.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis NP_600838.1 cleaves prepilin-like proteins NP_600839.1 similar to arsR family NP_600840.1 similar to ABC-type cobalamin/Fe3+-siderophores transport systems NP_600841.2 similar to ABC-type cobalamin/Fe3+-siderophores transport systems NP_600842.1 similar to ABC-type cobalamin/Fe3+-siderophores transport systems NP_600843.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate NP_600845.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function NP_600846.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_600849.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes NP_600851.1 similar to superfamily II DNA/RNA helicases, SNF2 family NP_600856.1 similar to related flavin-dependent oxidoreductases NP_600861.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG NP_600862.1 similar to glyoxylases NP_600863.1 cyclophilin family NP_600867.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis NP_600868.1 similar to ABC-type dipeptide/oligopeptide/nickel transport systems, periplasmic components NP_600869.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF NP_600870.2 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane NP_600872.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration NP_600873.1 plays an essential role in ATP-dependent branch migration of the Holliday junction NP_600874.2 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity NP_600880.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA NP_600882.1 similar to other HIT family hydrolases NP_600883.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) NP_600886.1 similar to Cu resistance protein CopC NP_600899.1 similar to ABC-type multidrug transport system NP_600921.1 similar to molecular chaperones NP_600923.2 similar to DNA invertase Pin NP_600942.1 similar to methyl-accepting chemotaxis protein NP_600959.1 contains LysM domain NP_600964.1 similar to MoxR-like ATPases NP_600969.2 similar to superfamily I DNA and RNA helicases NP_600974.1 contains MutT-like domain; similar to NTP pyrophosphohydrolases including oxidative damage repair enzymes NP_600979.1 similar to DNA-directed RNA polymerase beta subunit; 140 kD subunit (split gene in Mjan, Mthe, Aful) NP_600980.1 similar to type II 5-cytosine methyltransferase NP_600981.1 similar to type II resctriction endonuclease NP_600987.1 similar to superfamily II DNA/RNA helicases, SNF2 family; hypothetical protein NP_600994.1 similar to permeases of the major facilitator superfamily NP_601007.1 similar to nuclease subunit of the excinuclease complex NP_601026.1 ClpP class NP_601045.1 similar DNA topoisomerase III NP_601046.1 similar to superfamily II DNA and RNA helicases NP_601055.1 thermonuclease NP_601074.1 similar to trypsin NP_601086.2 contains integrase core domain NP_601087.1 similar to transposases NP_601090.1 contains transposase DDE domain NP_601091.1 similar to uncharacterized low-complexity proteins NP_601097.2 similar to integrase NP_601102.1 riboflavin biosynthesis NP_601104.1 contains conserved domain frequently associated with peptide methionine sulfoxide reductase NP_601108.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate NP_601109.1 related to tRNA (uracil-5-)-methyltransferase NP_601111.1 catalyzes the formation of dUMP from dUTP NP_601114.1 similar to DNA-directed RNA polymerase beta subunit/140 kD subunit (split gene in Mjan, Mthe, Aful) NP_601115.1 related to enzymes of inositol monophosphatase NP_601117.2 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released NP_601119.1 contains glutamate synthase domain 2 NP_601120.1 similar to DNA or RNA helicases of superfamily II NP_601124.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine NP_601125.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma factors in this cluster are active during stationary phase NP_601129.1 similar to archaeal enzymes of ATP-grasp superfamily NP_601130.1 similar to superfamily II DNA and RNA helicases NP_601134.1 contains Zn-ribbon and ATP-cone domains NP_601136.1 Represses a number of genes involved in the response to DNA damage NP_601138.1 similar to fructose-6-phosphate kinase (PfkB) and anaerobic selenocysteine-containing dehydrogenases NP_601139.1 PTS system EI component NP_601142.1 also similar to fructose-6-phosphate kinase (PfkB) NP_601143.1 contains mannitol/fructose-specific IIA domain (Ntr-type) NP_601144.1 similar to phosphotransferase system, HPr-related proteins NP_601147.2 COG2262:GTPases NP_601150.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate NP_601151.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity NP_601153.1 ATPase involved in DNA repair NP_601154.1 similar to histone acetyltransferase HPA2 and related acetyltransferases NP_601156.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) NP_601161.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities NP_601162.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs NP_601165.1 similar to biotin synthases NP_601166.1 similar to ABC-type cobalt transport systems NP_601167.1 similar to ABC-type cobalt transport systems NP_601168.1 suppresses sigma54-dependent transcription NP_601173.1 possibly involved in tellurium resistance NP_601174.1 similar to ABC-type cobalamin/Fe3+-siderophores transport systems, permeases NP_601177.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis NP_601178.1 flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor NP_601179.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis NP_601182.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence NP_601184.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities NP_601185.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs NP_601190.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock NP_601191.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex NP_601192.1 implicated in transcription termination NP_601193.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination NP_601194.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins NP_601196.1 similar to ABC-type dipeptide/oligopeptide/nickel transport systems NP_601197.1 similar to ABC-type dipeptide/oligopeptide/nickel transport systems NP_601198.1 similar to ABC-type dipeptide/oligopeptide/nickel transport systems NP_601199.1 similar to ABC-type dipeptide/oligopeptide/nickel transport systems; contains duplicated ATPase NP_601200.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) NP_601207.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate NP_601208.1 similar to lysophospholipase NP_601209.1 catalyzes the reduction of mycothione or glutathione to mycothione or glutathione disulfide NP_601213.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mnin Bacillus subtilis the protein in this cluster is considered non-essential NP_601214.1 similar to penicillin-binding protein 2 NP_601215.1 contains a CheY-like receiver domain and a HTH DNA-binding domain NP_601217.1 similar to ABC transporter involved in lipoprotein release NP_601218.1 similar to ABC transporter involved in lipoprotein release NP_601219.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis NP_601221.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate NP_601224.1 similar to ABC-type multidrug transport system NP_601225.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance NP_601228.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs NP_601229.2 Catalyzes the phosphorylation of UMP to UDP NP_601230.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu NP_601231.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit NP_601233.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs NP_601234.1 involved in DNA uptake NP_601235.2 similar to magnesium chelatase, subunit ChlI NP_601236.1 distantly related to archaeal Holliday junction resolvase NP_601237.1 similar to CTP synthase (UTP-ammonia lyase) NP_601238.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids NP_601240.1 similar to ABC-type cobalamin/Fe3+-siderophores transport systems NP_601241.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site NP_601242.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate NP_601243.1 deaminating NP_601244.1 involved in thiamine biosynthesis NP_601245.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate NP_601246.1 catalyzes the adenylation of ThiS which is involved in the formation of 5-methyl-4-(beta-hydroxyethyl)thiazole phosphate NP_601247.1 contains S1 domain NP_601253.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA NP_601255.1 Essential for efficient processing of 16S rRNA NP_601256.1 contains double-stranded beta-helix domain NP_601257.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity NP_601259.1 similar to ABC-type multidrug transport system NP_601260.1 similar to ABC-type multidrug transport system NP_601262.1 Uridylylates and de-uridylylates the small trimeric protein Pii NP_601264.2 PF00909:Ammonium Transporter Family; TIGR00836:amt: ammonium transporter; COG0004:Ammonia permeases NP_694659.1 catalyzes the hydrolysis of acylphosphate NP_601273.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases NP_601274.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity NP_601275.1 similar to metal-binding and nucleic acid-binding proteins NP_601277.2 similar to ABC-type multidrug/protein/lipid transport system NP_601278.1 similar to ABC-type multidrug/protein/lipid transport system NP_601279.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer NP_601282.1 similar to galactose-1-phosphate uridylyltransferase NP_601288.2 catalyzes the formation of phosphoenolpyruvate from pyruvate NP_601289.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein NP_601292.1 PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers NP_601293.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase NP_601294.1 similar to related enzymes of inositol monophosphatase NP_601295.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide and the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)anthranilate; involved in histidine and tryptophan biosynthesis NP_601296.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide NP_601299.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis NP_601300.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis NP_601301.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer NP_601306.1 similar to related glycosidases NP_601311.1 similar to ABC-type cobalamin/Fe3+-siderophores transport systems NP_601312.2 similar to ABC-type cobalamin/Fe3+-siderophores transport systems NP_601313.2 similar to ABC-type cobalamin/Fe3+-siderophores transport systems NP_601316.2 similar to related 3'-5' exonucleases NP_601321.1 similar to ribosomal protein S6 NP_601323.1 similar to related flavin-dependent oxidoreductases NP_601324.1 implicated in the recycling of the 50S subunit; similar to S4 NP_601328.2 catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic NP_601330.1 cobalamin-independent NP_601331.2 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase NP_601333.2 similar to ABC-type amino acid transport system, periplasmic component NP_601335.1 contain different specificities; related to short-chain alcohol dehydrogenases NP_601342.1 duplicated ATPase; similar to ATPases of ABC transporters with duplicated ATPase domains NP_601344.1 archaeal Glu-tRNAGln amidotransferase subunit D NP_601346.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function NP_601350.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin) NP_601357.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function NP_601359.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis NP_601360.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis NP_601362.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation NP_601363.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan NP_601365.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate NP_601366.1 similar to penicillin-binding protein 2 NP_601368.1 involved in cell envelope biogenesis NP_601369.1 MraZ; UPF0040; crystal structure shows similarity to AbrB NP_601374.1 similar to histone acetyltransferase HPA2 and related acetyltransferases NP_601385.1 similar to esterase NP_601387.1 similar to fucose 4-O-acetylase and related acetyltransferases NP_601389.1 similar to transcriptional regulators NP_601391.2 similar to invasion-associated proteins NP_601392.1 similar to invasion-associated proteins NP_601395.2 mono- and diheme variants NP_601396.2 similar to heme/copper-type cytochrome/quinol oxidase, subunit 3 NP_601399.1 similar to heme/copper-type cytochrome/quinol oxidases, subunit 2 NP_601400.1 glutamine-hydrolyzing; similar to lysozyme insensitivity protein LtsA NP_601403.1 similar to adenosyl cobinamide phosphate guanylyltransferase NP_601404.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole NP_601405.1 catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole NP_601407.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids NP_601408.2 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides NP_601410.1 E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains NP_601411.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein NP_601412.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group NP_601415.1 contains integrase core domain NP_601419.1 contains double-stranded beta-helix domain NP_601420.1 contains MutT-like domain; similar to oxidative damage repair enzymes NP_601421.1 similar to related flavin-dependent oxidoreductases NP_601423.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine NP_601426.1 similar to permease of the major facilitator superfamily NP_601427.2 similar to permease of the major facilitator superfamily NP_601428.1 similar to permease of the major facilitator superfamily NP_601430.1 similar to heme oxygenase NP_601431.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme NP_601434.2 similar to pyridoxine biosynthesis enzyme NP_601438.1 fructose-2,6-bisphosphatase NP_601439.1 nucleic acid-binding NP_694661.1 similar to transposases NP_694662.1 similar to transposases NP_601447.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC NP_601448.1 similar to various ABC transporters NP_601449.1 similar to branched-chain amino acid ABC-type transport system NP_601450.1 COG2984:hypotheical protein NP_601453.2 memebr of the alpha/beta hydrolase superfamily NP_601456.1 similar to ATPases of ABC transporters with duplicated ATPase domains NP_601458.2 similar to other penicillin binding proteins NP_601468.1 synthesizes RNA primers at the replication forks NP_601469.1 similar to ribonuclease NP_601471.2 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source NP_601473.1 dGTPase type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate NP_601478.1 Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_601483.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate NP_601484.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA NP_601485.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome NP_601486.1 similar to hemolysins NP_601488.2 predicted ATPase NP_601489.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase NP_601490.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion NP_601491.2 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons NP_601492.2 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III NP_601498.1 similar to ABC-type multidrug/protein/lipid transport system YP_008998236.1 membrane protein NP_601503.1 probably involved in trehalose biosynthesis NP_601504.2 catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate NP_601508.1 cystathionine beta-lyase NP_601510.1 similar to related flavin-dependent oxidoreductases NP_601511.1 choline-glycine betaine transporter NP_601520.1 similar to ABC-type dipeptide/oligopeptide/nickel transport systems NP_601521.1 similar to ABC-type dipeptide/oligopeptide/nickel transport systems NP_601522.1 similar to ABC-type dipeptide/oligopeptide/nickel transport systems NP_601523.1 similar to ATPases of various ABC-type transport systems NP_601525.1 ribokinase NP_601529.2 related to aldose 1-epimerase NP_601530.1 catalyzes the formation of malate from glyoxylate and acetyl-CoA NP_601531.1 Catalyzes the first step in the glyoxalate cycle, which converts lipids to carbohydrates NP_601539.1 possible transporter NP_601542.1 binds to the ribosome on the universally-conserved alpha-sarcin loop NP_601544.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase NP_601547.1 required for the assembly and function of the DNAX complex which are required fro the assembly of the beta subunit onto primed DNA NP_601548.1 predicted multitransmembrane; metal-binding protein NP_601549.1 similar to related DNA-binding proteins NP_601551.1 phosphoglycerate mutase NP_601552.1 similar to plant Iojap proteins NP_601553.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria NP_601555.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway NP_601557.2 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis NP_601558.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication NP_601560.2 related to diketogulonate reductase NP_601563.1 involved in the peptidyltransferase reaction during translation NP_601571.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate NP_601577.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain NP_601578.1 similar to ABC-type dipeptide/oligopeptide/nickel transport systems NP_601581.1 catalyzes the oxidation of malate to oxaloacetate NP_601585.1 similar to ferredoxin-NADPH reductases NP_601588.1 binds and unfolds substrates as part of the ClpXP protease NP_601593.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation NP_601594.1 member of the alpha/beta hydrolase superfamily NP_601595.1 similar to ATP-dependent transcriptional regulator NP_601596.1 similar to gamma-carboxymuconolactone decarboxylase subunit NP_601597.2 similar to adenylosuccinate lyase NP_601600.1 similar to restriction endonucleases NP_601601.1 similar to muconolactone delta-isomerase NP_601606.1 with BenAB catalyzes the formation of 2-hydro-1,2-dihydroxybenzoate from benzoate NP_601607.1 catalyzes the degradation of 2-hydro-1,2-dihydroxy benzoate to catechol NP_601611.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates NP_601612.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates NP_601613.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer NP_601615.1 similar to other penicillin binding proteins NP_601621.1 catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity NP_601633.1 contains alkylhydroperoxidase AhpD family core domain NP_601634.1 similar to ATPases of various ABC-type transport systems; contains duplicated ATPase NP_601635.1 similar to ABC-type dipeptide/oligopeptide/nickel transport systems NP_601636.1 similar to ABC-type dipeptide/oligopeptide/nickel transport systems NP_601637.1 similar to ABC-type dipeptide/oligopeptide/nickel transport systems NP_601642.1 similar to short-chain alcohol dehydrogenases NP_601644.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine NP_601645.2 similar to ABC-type molybdenum transport system; ATPase/photorepair protein PhrA NP_601652.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence NP_601654.1 similar to ABC transporter permeases NP_601658.1 similar to sugar permeases NP_601659.1 similar to sugar permeases NP_601660.1 similar to maltose-binding periplasmic proteins NP_601662.1 similar to ABC-type sugar transport systems NP_601663.1 involved in cell wall biogenesis NP_601664.1 similar to integrase; possible member of Phage integrase NP_601668.1 similar to NAD-dependent aldehyde dehydrogenase NP_601669.1 similar to NCAIR mutase (PurE)-related proteins and Zn-dependent alcohol dehydrogenases, class III NP_601672.1 unknown substrate specificity NP_601673.1 3'-5' exoribonuclease specific for small oligoribonuclotides NP_601674.2 similar to enterochelin esterase NP_601682.1 catalyzes the formation of glutamate from glutamine NP_601685.2 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism NP_601688.1 related to nicotinamidase NP_601691.2 PF00440:Bacterial regulatory proteins, tetR family; COG1309:transcriptional regulator NP_601692.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids NP_601702.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine NP_601703.2 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs NP_601706.1 contains integrase core domain NP_601708.1 contains integrase core domain NP_601710.1 member of the beta-lactamase superfamily III NP_601711.1 converts L-glutamate to D-glutamate, a component of peptidoglycan NP_601714.1 similar to Drosophila rhomboid NP_601717.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA NP_601718.1 contains SCP/PR1 domains NP_601719.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate NP_601723.1 contains ACT domain NP_601725.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE NP_601730.1 Catalyzes the rate-limiting step in dNTP synthesis NP_601731.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF NP_601734.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers NP_601735.1 COG3001:hypotheical protein NP_601737.1 similar to related Zn-dependent oxidoreductases NP_601738.1 involved in propionate catabolism NP_601741.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate NP_601742.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling NP_601743.1 CrcB-like protein; similar to integral membrane protein possibly involved in chromosome condensation NP_601749.1 TnpC-like protein NP_601752.2 involved in lipoprotein release, permeases NP_601753.1 involved in lipoprotein release, ATPases NP_601754.1 similar to sugar phosphate isomerases/epimerases NP_601756.1 similar to SAM-dependent methyltransferases NP_601757.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active NP_601759.1 contains a CheY-like receiver domain and an HTH DNA-binding domain NP_601763.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle NP_601764.2 catalyzes the interconversion of succinyl-CoA and succinate NP_601765.1 involved in polyketide biosynthesis NP_601768.2 possibly dehydrogenases, nifR3 family NP_601770.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation NP_601771.1 similar to ABC-type phosphate transport system NP_601772.2 similar to ABC-type phosphate transport system NP_601773.1 similar to ABC-type phosphate transport system NP_601776.1 similar to diacylglycerol kinase NP_601778.2 catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate NP_601781.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis NP_601782.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway NP_601785.1 hemolysin III -like proteins NP_601786.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis NP_601787.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis NP_601788.1 With PurL and PurQ catalyzes the conversion of formylglycinamide ribonucleotide, ATP, and glutamine to formylglycinamidine ribonucleotide, ADP, and glutamate in the fourth step of the purine biosynthetic pathway NP_601795.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase NP_601798.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide NP_601800.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis NP_601801.1 similar to other HIT family hydrolases NP_601805.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate NP_601806.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium NP_601808.1 contains a CheY-like receiver domain and a HTH DNA-binding domain NP_601811.1 catalyzes the formation of acetate from pyruvate NP_601819.1 similar to poly(3-hydroxybutyrate) depolymerase NP_601823.1 similar to threonine export carrier NP_601829.1 similar to ABC-type Mn/Zn transport system; periplasmic Mn/Zn-binding (lipo)protein; surface adhesin A NP_601830.1 similar to ABC-type cobalamin/Fe3+-siderophores transport systems NP_601831.1 similar to ABC-type Mn2+/Zn2+ transport systems NP_601832.1 contains integrase core domain NP_601841.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA NP_601842.1 glucose/maltose/N-acetylglucosamine-specific NP_601843.2 levanase/invertase NP_601848.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate NP_601851.1 similar to ABC-type dipeptide/oligopeptide/nickel transport systems NP_601852.2 similar to ABC-type dipeptide/oligopeptide/nickel transport systems NP_601853.2 similar to ABC-type dipeptide/oligopeptide/nickel transport systems NP_601854.1 similar to various ABC-type transport systems NP_601858.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate NP_601859.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers NP_601860.1 similar to M. xanthus CarD NP_601861.1 contains a CheY-like receiver domain and a HTH DNA-binding domain NP_601864.2 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents NP_601865.1 non-specific DNA-binding; scans chromosomes during sporulation for DNA-damage; delays initiation of sporulation; participates in a checkpoint signaling cascade for cell-cycle progression and DNA repair NP_601873.1 involved in biosynthesis of extracellular polysaccharides NP_601875.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate NP_601877.1 catalyzes the formation of catechol from phenol NP_601883.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 NP_601884.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine NP_601891.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer NP_601893.1 Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively NP_601894.1 implicated in cell cycle control NP_601895.1 penicillin-binding protein 4 NP_601896.1 Catalyzes the hydrolysis of pyrophosphate NP_601897.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine NP_601902.1 similar to phosphotransferase system IIC components; glucose/maltose/N-acetylglucosamine-specific NP_694668.1 similar to phosphotransferase system IIC components; glucose/maltose/N-acetylglucosamine-specific NP_601908.1 NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate NP_601912.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth NP_601922.1 similar to acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases NP_601923.1 similar to acetyl-CoA acetyltransferases NP_601924.1 subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali NP_601925.1 subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali NP_601926.2 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone NP_601927.1 subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport NP_601928.1 subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali NP_601929.1 subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali NP_601930.1 similar to predicted hydrolases or acyltransferases; alpha/beta hydrolase superfamily NP_601931.1 ATP-dependent carboxylate-amine ligase NP_601934.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) NP_601937.1 similar to phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthases and related enzymes NP_601940.2 PhzC/PhzF-like protein NP_601941.2 similar to ABC-type multidrug transport system NP_601942.1 similar to ABC-type multidrug transport system NP_601943.1 similar to oxidative damage repair enzymes; contains MutT-like domain NP_601945.1 similar to ABC-type amino acid transport system NP_601947.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA NP_601948.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta NP_601954.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis NP_601956.1 contains integrase core domain NP_601957.1 similar to transposases NP_601959.1 contains a CheY-like receiver domain and a HTH DNA-binding domain NP_601960.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis NP_601964.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate NP_601965.1 similar to alpha-1,6-mannanase NP_601967.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate NP_601970.1 similar to predicted transcriptional regulators NP_601971.1 similar to permeases of the major facilitator superfamily NP_601978.1 similar to coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases NP_601984.1 similar to related flavodoxin oxidoreductases NP_601990.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion NP_601991.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor NP_601992.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria NP_601994.1 Catalyzes hydrolysis of n-ribosyl-purine into a purine and d-ribose NP_602006.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP NP_602017.1 similar to ABC-type cobalamin/Fe3+-siderophores transport systems NP_602018.1 similar to ABC transporter involved in lipoprotein release NP_602020.1 similar to acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase and related deacylases NP_602022.1 similar to ABC-type cobalt transport system NP_602023.1 similar to ABC-type cobalt transport system NP_602024.1 similar to ABC transporter permease NP_602027.1 similar to stomatin/prohibitin NP_602032.1 similar to predicted dinucleotide-binding enzymes NP_602033.1 similar to transcriptional antiterminators NP_602035.1 similar to beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase NP_602036.1 similar to ABC-type cobalamin/Fe3+-siderophores transport systems NP_602037.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor NP_602038.2 contains integrase core domain NP_602041.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis NP_602043.1 similar to vancomycin resistance protein NP_602045.1 similar to universal stress protein UspA and related nucleotide-binding proteins NP_602055.1 catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using GTP NP_602056.1 similar to tellurite resistance protein and related permeases NP_602057.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine NP_602059.1 similar to predicted drug exporters of the RND superfamily NP_602064.1 Activates fatty acids by binding to coenzyme A NP_602067.1 similar to alpha-antigen NP_602071.1 catalyzes the formation of decaprenylphosphoryl-5-phosphoribose from phosphoribose diphosphate and decaprenyl phosphate NP_602073.1 similar to glycosyltransferases NP_602080.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP NP_602081.1 similar to predicted hydrolases of the HAD superfamily NP_602083.2 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_602087.1 similar to fructose-2,6-bisphosphatase NP_602088.1 catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis NP_602089.2 similar to Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases NP_602090.1 similar to predicted metal-dependent membrane protease NP_602094.1 similar to gamma-carboxymuconolactone decarboxylase subunit NP_602099.1 catalyzes the formation of phosphoenolpyruvate from pyruvate NP_602100.1 Converts (S)-lactate and NAD(+) to pyruvate and NADH NP_602105.1 similar to diadenosine tetraphosphatase and related serine/threonine protein phosphatases NP_602106.1 similar to permeases of the major facilitator superfamily NP_602107.1 FMN-dependent NP_602109.1 similar to transcriptional regulators and immunity repressor proteins NP_602110.1 similar to phosphohydrolases and purple acid phosphatase NP_602113.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress NP_602116.1 similar to permeases of the major facilitator superfamily NP_602118.1 similar to predicted RecB family nuclease (associated with helicases in Pyrococcus and Mtub) NP_602120.1 similar to permeases of the major facilitator superfamily NP_602122.1 contins a CheY-like receiver domain and a HTH DNA-binding domain NP_602126.2 similar to sortase; surface protein transpeptidase NP_602127.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria NP_602130.1 similar to universal stress protein UspA and related nucleotide-binding proteins NP_602131.2 similar to coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases NP_602135.2 similar to pneumococcal surface protein A NP_602136.1 similar to phage shock protein A (IM30), suppresses sigma54-dependent transcription and pneumococcal surface protein A NP_602142.2 similar to SAM-dependent methyltransferase NP_602148.1 contains double-stranded beta-helix domain YP_008998239.1 hexameric tyrosine-coordinated heme protein NP_602153.1 similar to cation transport ATPases NP_602156.1 containing a CheY-like receiver domain and a HTH DNA-binding domain NP_602160.1 similar to zinc-binding dehydrogenases NP_602162.2 contains cAMP-binding domains - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases NP_602163.1 contains heavy-metal-associated domain NP_602166.1 possible for cadmium NP_602170.1 contains heavy-metal-associated domain NP_602171.2 similar to permeases of the major facilitator superfamily NP_602173.2 similar to predicted transcriptional regulators NP_602175.1 unwinds double stranded DNA NP_602176.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk NP_602177.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA NP_602178.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 NP_602185.1 similar to universal stress protein UspA and related nucleotide-binding proteins NP_602187.1 involved in biosynthesis of extracellular polysaccharides NP_602188.1 similar to sulfurtransferases NP_602189.1 similar to ABC transporter involved in lipoprotein release NP_602190.1 similar to ABC transporter involved in lipoprotein release NP_602200.1 similar to NADPH:quinone reductase and related Zn-dependent oxidoreductases NP_602201.1 similar to arabinose efflux permease NP_602203.1 pentulose and hexulose NP_602206.1 similar to dihydrolipoamide dehydrogenase/glutathione oxidoreductase and related enzymes NP_602213.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase NP_602214.1 similar to plasmid maintenance system antidote protein NP_602215.1 in Corynebacterium glutamicum this enzyme catalyzes the conversion of maleylpyruvate into fumarylpyruvate in a glutathione-independent gentisate pathway; dependent on mycothiol NP_602216.1 bifunctional; similar to 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway); 5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioatedecarboxylase NP_602219.1 similar to permeases of the major facilitator superfamily NP_602220.1 similar to 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases NP_602221.1 similar to Na+/H+-dicarboxylate symporters NP_602223.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine NP_602224.1 TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity NP_602225.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate NP_602226.2 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate NP_602227.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate NP_602228.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis NP_602229.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr NP_602230.1 similar to hosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) NP_602231.1 similar to ABC-type multidrug transport system NP_602232.2 similar to exporter of polyketide antibiotics NP_602233.2 contains Rieske [2Fe-2S] domain; similar to ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases NP_602234.2 member of the Old Yellow Enzyme family NP_602235.1 similar to predicted Na+-dependent transporter NP_602238.1 member of the Old Yellow Enzyme family NP_602239.1 similar to predicted nucleoside-diphosphate-sugar epimerases NP_602244.1 similar to dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) NP_602245.1 similar to Sec-independent protein secretion pathway components NP_602248.1 similar to protocatechuate 3,4-dioxygenase beta subunit NP_602249.1 similar to alcohol dehydrogenase IV NP_602250.1 similar to permeases of the major facilitator superfamily NP_602252.1 similar to predicted dehydrogenases and related proteins NP_602253.1 similar to sugar phosphate isomerases/epimerases NP_602254.1 similar to predicted dehydrogenases and related proteins NP_602255.1 similar to predicted dehydrogenases and related proteins NP_602258.1 similar to permeases of the major facilitator superfamily NP_602259.1 similar to membrane protease subunits, stomatin/prohibitin-like proteins NP_602261.1 similar to restriction enzymes type I helicase subunits and DNA or RNA helicases of superfamily II NP_602262.1 similar to permeases of the major facilitator superfamily NP_694678.1 similar to methylated-DNA--protein-cysteine methyltransferase NP_602264.1 contains heavy-metal-associated domain NP_602265.1 similar to permeases of the major facilitator superfamily NP_602266.1 similar to ABC-type cobalamin/Fe3+-siderophores transport systems NP_602267.1 similar to NADPH:quinone reductase and related Zn-dependent oxidoreductases NP_602270.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine NP_602272.1 contains heavy-metal-associated domain NP_602273.1 similar to predicted branched-chain amino acid transport protein; azaleucine resistance NP_602274.1 possible azaleucine resistance NP_602275.1 similar to transcriptional regulators NP_602278.2 contains MutT-like domain; similar to NTP pyrophosphohydrolases including oxidative damage repair enzymes NP_602281.2 similar to sigma-70 factor (ECF subfamily) NP_602283.1 similar to thiol-disulfide isomerase and thioredoxins NP_602288.2 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA NP_602289.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria NP_602290.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates NP_602291.1 in Escherichia coli transcription of this gene is enhanced by polyamines