-- dump date 20140619_051439 -- class Genbank::misc_feature -- table misc_feature_note -- id note 196627000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 196627000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196627000003 Walker A motif; other site 196627000004 ATP binding site [chemical binding]; other site 196627000005 Walker B motif; other site 196627000006 arginine finger; other site 196627000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 196627000008 DnaA box-binding interface [nucleotide binding]; other site 196627000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 196627000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 196627000011 putative DNA binding surface [nucleotide binding]; other site 196627000012 dimer interface [polypeptide binding]; other site 196627000013 beta-clamp/clamp loader binding surface; other site 196627000014 beta-clamp/translesion DNA polymerase binding surface; other site 196627000015 recombination protein F; Reviewed; Region: recF; PRK00064 196627000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 196627000017 Walker A/P-loop; other site 196627000018 ATP binding site [chemical binding]; other site 196627000019 Q-loop/lid; other site 196627000020 ABC transporter signature motif; other site 196627000021 Walker B; other site 196627000022 D-loop; other site 196627000023 H-loop/switch region; other site 196627000024 hypothetical protein; Provisional; Region: PRK00111 196627000025 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 196627000026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196627000027 ATP binding site [chemical binding]; other site 196627000028 Mg2+ binding site [ion binding]; other site 196627000029 G-X-G motif; other site 196627000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 196627000031 anchoring element; other site 196627000032 dimer interface [polypeptide binding]; other site 196627000033 ATP binding site [chemical binding]; other site 196627000034 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 196627000035 active site 196627000036 metal binding site [ion binding]; metal-binding site 196627000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 196627000038 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 196627000039 Putative lysophospholipase; Region: Hydrolase_4; cl19140 196627000040 Predicted membrane protein [Function unknown]; Region: COG2364 196627000041 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 196627000042 DNA gyrase subunit A; Validated; Region: PRK05560 196627000043 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 196627000044 CAP-like domain; other site 196627000045 active site 196627000046 primary dimer interface [polypeptide binding]; other site 196627000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 196627000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 196627000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 196627000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 196627000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 196627000052 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 196627000053 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 196627000054 Predicted membrane protein [Function unknown]; Region: COG2855 196627000055 Transcriptional regulator [Transcription]; Region: LysR; COG0583 196627000056 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 196627000057 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 196627000058 dimerization interface [polypeptide binding]; other site 196627000059 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 196627000060 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 196627000061 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 196627000062 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 196627000063 Predicted transcriptional regulator [Transcription]; Region: COG3682 196627000064 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 196627000065 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 196627000066 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 196627000067 Divergent AAA domain; Region: AAA_4; pfam04326 196627000068 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 196627000069 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 196627000070 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 196627000071 Periplasmic solute binding protein family; Region: TroA; pfam01297 196627000072 intersubunit interface [polypeptide binding]; other site 196627000073 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 196627000074 ABC-ATPase subunit interface; other site 196627000075 dimer interface [polypeptide binding]; other site 196627000076 putative PBP binding regions; other site 196627000077 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 196627000078 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196627000079 Walker A/P-loop; other site 196627000080 ATP binding site [chemical binding]; other site 196627000081 Q-loop/lid; other site 196627000082 ABC transporter signature motif; other site 196627000083 Walker B; other site 196627000084 D-loop; other site 196627000085 H-loop/switch region; other site 196627000086 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 196627000087 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 196627000088 putative ligand binding site [chemical binding]; other site 196627000089 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 196627000090 TM-ABC transporter signature motif; other site 196627000091 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 196627000092 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 196627000093 Walker A/P-loop; other site 196627000094 ATP binding site [chemical binding]; other site 196627000095 Q-loop/lid; other site 196627000096 ABC transporter signature motif; other site 196627000097 Walker B; other site 196627000098 D-loop; other site 196627000099 H-loop/switch region; other site 196627000100 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 196627000101 active site 196627000102 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 196627000103 Helix-turn-helix domain; Region: HTH_18; pfam12833 196627000104 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 196627000105 Helix-turn-helix domain; Region: HTH_18; pfam12833 196627000106 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 196627000107 ABC-ATPase subunit interface; other site 196627000108 dimer interface [polypeptide binding]; other site 196627000109 putative PBP binding regions; other site 196627000110 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 196627000111 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 196627000112 Walker A/P-loop; other site 196627000113 ATP binding site [chemical binding]; other site 196627000114 Q-loop/lid; other site 196627000115 ABC transporter signature motif; other site 196627000116 Walker B; other site 196627000117 D-loop; other site 196627000118 H-loop/switch region; other site 196627000119 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 196627000120 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 196627000121 FAD binding pocket [chemical binding]; other site 196627000122 FAD binding motif [chemical binding]; other site 196627000123 phosphate binding motif [ion binding]; other site 196627000124 NAD binding pocket [chemical binding]; other site 196627000125 putative septation inhibitor protein; Reviewed; Region: PRK00159 196627000126 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 196627000127 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 196627000128 active site 196627000129 ATP binding site [chemical binding]; other site 196627000130 substrate binding site [chemical binding]; other site 196627000131 activation loop (A-loop); other site 196627000132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 196627000133 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 196627000134 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 196627000135 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 196627000136 PASTA domain; Region: PASTA; pfam03793 196627000137 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 196627000138 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 196627000139 active site 196627000140 ATP binding site [chemical binding]; other site 196627000141 substrate binding site [chemical binding]; other site 196627000142 activation loop (A-loop); other site 196627000143 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 196627000144 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 196627000145 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 196627000146 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 196627000147 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 196627000148 active site 196627000149 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 196627000150 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 196627000151 phosphopeptide binding site; other site 196627000152 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 196627000153 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 196627000154 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 196627000155 phosphopeptide binding site; other site 196627000156 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 196627000157 tetramerization interface [polypeptide binding]; other site 196627000158 NAD(P) binding site [chemical binding]; other site 196627000159 catalytic residues [active] 196627000160 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979 196627000161 dimer interface [polypeptide binding]; other site 196627000162 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 196627000163 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 196627000164 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 196627000165 active site residue [active] 196627000166 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 196627000167 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 196627000168 active site residue [active] 196627000169 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 196627000170 active site residue [active] 196627000171 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 196627000172 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 196627000173 putative homodimer interface [polypeptide binding]; other site 196627000174 putative homotetramer interface [polypeptide binding]; other site 196627000175 putative allosteric switch controlling residues; other site 196627000176 putative metal binding site [ion binding]; other site 196627000177 putative homodimer-homodimer interface [polypeptide binding]; other site 196627000178 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 196627000179 putative metal binding residues [ion binding]; other site 196627000180 signature motif; other site 196627000181 dimer interface [polypeptide binding]; other site 196627000182 active site 196627000183 polyP binding site; other site 196627000184 substrate binding site [chemical binding]; other site 196627000185 acceptor-phosphate pocket; other site 196627000186 MgtC family; Region: MgtC; pfam02308 196627000187 Spore coat assembly protein [Cell envelope biogenesis, outer membrane]; Region: CotH; COG5337 196627000188 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 196627000189 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 196627000190 oligomer interface [polypeptide binding]; other site 196627000191 metal binding site [ion binding]; metal-binding site 196627000192 metal binding site [ion binding]; metal-binding site 196627000193 putative Cl binding site [ion binding]; other site 196627000194 basic sphincter; other site 196627000195 hydrophobic gate; other site 196627000196 periplasmic entrance; other site 196627000197 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 196627000198 hexamer interface [polypeptide binding]; other site 196627000199 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 196627000200 active site 2 [active] 196627000201 dimer interface [polypeptide binding]; other site 196627000202 hexamer interface [polypeptide binding]; other site 196627000203 active site 2 [active] 196627000204 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 196627000205 putative ion selectivity filter; other site 196627000206 putative pore gating glutamate residue; other site 196627000207 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 196627000208 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 196627000209 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 196627000210 putative active site [active] 196627000211 PhoH-like protein; Region: PhoH; pfam02562 196627000212 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 196627000213 Citrate transporter; Region: CitMHS; pfam03600 196627000214 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 196627000215 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 196627000216 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 196627000217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196627000218 ATP binding site [chemical binding]; other site 196627000219 Mg2+ binding site [ion binding]; other site 196627000220 G-X-G motif; other site 196627000221 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 196627000222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196627000223 active site 196627000224 phosphorylation site [posttranslational modification] 196627000225 intermolecular recognition site; other site 196627000226 dimerization interface [polypeptide binding]; other site 196627000227 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 196627000228 putative DNA binding site [nucleotide binding]; other site 196627000229 putative Zn2+ binding site [ion binding]; other site 196627000230 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 196627000231 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 196627000232 putative ligand binding site [chemical binding]; other site 196627000233 putative NAD binding site [chemical binding]; other site 196627000234 catalytic site [active] 196627000235 biotin synthase; Validated; Region: PRK06256 196627000236 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 196627000237 FeS/SAM binding site; other site 196627000238 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 196627000239 CHY zinc finger; Region: zf-CHY; cl19861 196627000240 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196627000241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627000242 putative substrate translocation pore; other site 196627000243 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 196627000244 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 196627000245 active site 196627000246 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 196627000247 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 196627000248 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 196627000249 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 196627000250 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 196627000251 Transcriptional regulators [Transcription]; Region: MarR; COG1846 196627000252 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 196627000253 putative DNA binding site [nucleotide binding]; other site 196627000254 putative Zn2+ binding site [ion binding]; other site 196627000255 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 196627000256 alpha-gamma subunit interface [polypeptide binding]; other site 196627000257 beta-gamma subunit interface [polypeptide binding]; other site 196627000258 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 196627000259 gamma-beta subunit interface [polypeptide binding]; other site 196627000260 alpha-beta subunit interface [polypeptide binding]; other site 196627000261 Urea amidohydrolase (urease) alpha subunit [Amino acid transport and metabolism]; Region: UreC; COG0804 196627000262 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 196627000263 subunit interactions [polypeptide binding]; other site 196627000264 active site 196627000265 flap region; other site 196627000266 Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371 196627000267 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 196627000268 dimer interface [polypeptide binding]; other site 196627000269 catalytic residues [active] 196627000270 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 196627000271 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 196627000272 G1 box; other site 196627000273 GTP/Mg2+ binding site [chemical binding]; other site 196627000274 Switch I region; other site 196627000275 Switch II region; other site 196627000276 G4 box; other site 196627000277 G5 box; other site 196627000278 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 196627000279 Putative lysophospholipase; Region: Hydrolase_4; cl19140 196627000280 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 196627000281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627000282 putative substrate translocation pore; other site 196627000283 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196627000284 HSP90 family protein; Provisional; Region: PRK14083 196627000285 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196627000286 ATP binding site [chemical binding]; other site 196627000287 Mg2+ binding site [ion binding]; other site 196627000288 G-X-G motif; other site 196627000289 AMP nucleosidase; Region: AMP-nucleosdse; TIGR01717 196627000290 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 196627000291 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 196627000292 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 196627000293 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 196627000294 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 196627000295 PYR/PP interface [polypeptide binding]; other site 196627000296 dimer interface [polypeptide binding]; other site 196627000297 TPP binding site [chemical binding]; other site 196627000298 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 196627000299 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 196627000300 Proline dehydrogenase; Region: Pro_dh; pfam01619 196627000301 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 196627000302 NAD(P) binding site [chemical binding]; other site 196627000303 catalytic residues [active] 196627000304 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 196627000305 active site 196627000306 catalytic tetrad [active] 196627000307 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 196627000308 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 196627000309 amidohydrolase; Region: amidohydrolases; TIGR01891 196627000310 metal binding site [ion binding]; metal-binding site 196627000311 Predicted membrane protein [Function unknown]; Region: COG2149 196627000312 Domain of unknown function (DUF202); Region: DUF202; pfam02656 196627000313 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 196627000314 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 196627000315 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 196627000316 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 196627000317 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 196627000318 catalytic core [active] 196627000319 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 196627000320 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 196627000321 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 196627000322 polyol permease family; Region: 2A0118; TIGR00897 196627000323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627000324 putative substrate translocation pore; other site 196627000325 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 196627000326 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 196627000327 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 196627000328 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 196627000329 D-xylulose kinase; Region: XylB; TIGR01312 196627000330 nucleotide binding site [chemical binding]; other site 196627000331 Pantoate-beta-alanine ligase; Region: PanC; cd00560 196627000332 active site 196627000333 ATP-binding site [chemical binding]; other site 196627000334 pantoate-binding site; other site 196627000335 HXXH motif; other site 196627000336 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 196627000337 oligomerization interface [polypeptide binding]; other site 196627000338 active site 196627000339 metal binding site [ion binding]; metal-binding site 196627000340 Fic family protein [Function unknown]; Region: COG3177 196627000341 Fic/DOC family; Region: Fic; pfam02661 196627000342 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 196627000343 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 196627000344 active site 196627000345 DNA binding site [nucleotide binding] 196627000346 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 196627000347 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 196627000348 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 196627000349 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 196627000350 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 196627000351 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 196627000352 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196627000353 motif II; other site 196627000354 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 196627000355 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 196627000356 trimer interface [polypeptide binding]; other site 196627000357 putative metal binding site [ion binding]; other site 196627000358 Transcriptional regulators [Transcription]; Region: MarR; COG1846 196627000359 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 196627000360 putative DNA binding site [nucleotide binding]; other site 196627000361 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 196627000362 enterobactin exporter EntS; Provisional; Region: PRK10489 196627000363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627000364 putative substrate translocation pore; other site 196627000365 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 196627000366 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 196627000367 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 196627000368 DXD motif; other site 196627000369 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 196627000370 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 196627000371 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 196627000372 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 196627000373 Predicted permeases [General function prediction only]; Region: COG0730 196627000374 Predicted permeases [General function prediction only]; Region: RarD; COG2962 196627000375 Predicted membrane protein [Function unknown]; Region: COG2860 196627000376 UPF0126 domain; Region: UPF0126; pfam03458 196627000377 UPF0126 domain; Region: UPF0126; pfam03458 196627000378 Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187 196627000379 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 196627000380 tetramerization interface [polypeptide binding]; other site 196627000381 active site 196627000382 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805 196627000383 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 196627000384 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 196627000385 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 196627000386 hypothetical protein; Provisional; Region: PRK10621 196627000387 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 196627000388 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196627000389 ATP binding site [chemical binding]; other site 196627000390 putative Mg++ binding site [ion binding]; other site 196627000391 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196627000392 nucleotide binding region [chemical binding]; other site 196627000393 ATP-binding site [chemical binding]; other site 196627000394 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 196627000395 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 196627000396 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 196627000397 maltose O-acetyltransferase; Provisional; Region: PRK10092 196627000398 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 196627000399 active site 196627000400 substrate binding site [chemical binding]; other site 196627000401 trimer interface [polypeptide binding]; other site 196627000402 CoA binding site [chemical binding]; other site 196627000403 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 196627000404 3-methyladenine DNA glycosylase [DNA replication, recombination, and repair]; Region: Tag; COG2818 196627000405 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 196627000406 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 196627000407 RNA binding surface [nucleotide binding]; other site 196627000408 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 196627000409 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 196627000410 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 196627000411 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 196627000412 DNA binding site [nucleotide binding] 196627000413 active site 196627000414 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 196627000415 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 196627000416 homotrimer interaction site [polypeptide binding]; other site 196627000417 putative active site [active] 196627000418 glycogen branching enzyme; Provisional; Region: PRK14705 196627000419 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 196627000420 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 196627000421 active site 196627000422 Zn binding site [ion binding]; other site 196627000423 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 196627000424 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 196627000425 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 196627000426 DNA-binding site [nucleotide binding]; DNA binding site 196627000427 UTRA domain; Region: UTRA; pfam07702 196627000428 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 196627000429 substrate binding site [chemical binding]; other site 196627000430 ATP binding site [chemical binding]; other site 196627000431 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 196627000432 tetrameric interface [polypeptide binding]; other site 196627000433 NAD binding site [chemical binding]; other site 196627000434 catalytic residues [active] 196627000435 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 196627000436 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 196627000437 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 196627000438 PYR/PP interface [polypeptide binding]; other site 196627000439 dimer interface [polypeptide binding]; other site 196627000440 TPP binding site [chemical binding]; other site 196627000441 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 196627000442 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 196627000443 TPP-binding site; other site 196627000444 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 196627000445 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 196627000446 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 196627000447 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 196627000448 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 196627000449 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 196627000450 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 196627000451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627000452 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196627000453 putative substrate translocation pore; other site 196627000454 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 196627000455 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 196627000456 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 196627000457 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 196627000458 Transcriptional regulators [Transcription]; Region: PurR; COG1609 196627000459 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 196627000460 DNA binding site [nucleotide binding] 196627000461 domain linker motif; other site 196627000462 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 196627000463 dimerization interface [polypeptide binding]; other site 196627000464 ligand binding site [chemical binding]; other site 196627000465 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 196627000466 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 196627000467 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 196627000468 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 196627000469 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 196627000470 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 196627000471 DNA-binding site [nucleotide binding]; DNA binding site 196627000472 RNA-binding motif; other site 196627000473 putrescine transporter; Provisional; Region: potE; PRK10655 196627000474 Transcriptional regulators [Transcription]; Region: MarR; COG1846 196627000475 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 196627000476 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 196627000477 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196627000478 Coenzyme A binding pocket [chemical binding]; other site 196627000479 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 196627000480 Transcriptional regulators [Transcription]; Region: PurR; COG1609 196627000481 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 196627000482 DNA binding site [nucleotide binding] 196627000483 domain linker motif; other site 196627000484 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 196627000485 dimerization interface [polypeptide binding]; other site 196627000486 ligand binding site [chemical binding]; other site 196627000487 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 196627000488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627000489 putative substrate translocation pore; other site 196627000490 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 196627000491 Helix-turn-helix domain; Region: HTH_38; pfam13936 196627000492 Homeodomain-like domain; Region: HTH_32; pfam13565 196627000493 Integrase core domain; Region: rve; pfam00665 196627000494 PAS domain; Region: PAS_9; pfam13426 196627000495 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 196627000496 putative active site [active] 196627000497 heme pocket [chemical binding]; other site 196627000498 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 196627000499 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 196627000500 active site 196627000501 dimer interface [polypeptide binding]; other site 196627000502 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 196627000503 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 196627000504 active site 196627000505 FMN binding site [chemical binding]; other site 196627000506 substrate binding site [chemical binding]; other site 196627000507 3Fe-4S cluster binding site [ion binding]; other site 196627000508 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 196627000509 domain interface; other site 196627000510 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 196627000511 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 196627000512 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 196627000513 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 196627000514 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; cl19125 196627000515 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 196627000516 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 196627000517 EmbC C-terminal domain; Region: Arabino_trans_C; pfam14896 196627000518 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 196627000519 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 196627000520 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 196627000521 classical (c) SDRs; Region: SDR_c; cd05233 196627000522 NAD(P) binding site [chemical binding]; other site 196627000523 active site 196627000524 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 196627000525 FAD binding domain; Region: FAD_binding_4; pfam01565 196627000526 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 196627000527 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 196627000528 Predicted membrane protein [Function unknown]; Region: COG2246 196627000529 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 196627000530 MOSC domain; Region: MOSC; pfam03473 196627000531 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 196627000532 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 196627000533 active site 196627000534 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 196627000535 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 196627000536 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 196627000537 Walker A/P-loop; other site 196627000538 ATP binding site [chemical binding]; other site 196627000539 Q-loop/lid; other site 196627000540 ABC transporter signature motif; other site 196627000541 Walker B; other site 196627000542 D-loop; other site 196627000543 H-loop/switch region; other site 196627000544 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 196627000545 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 196627000546 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 196627000547 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 196627000548 NAD(P) binding site [chemical binding]; other site 196627000549 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 196627000550 catalytic loop [active] 196627000551 iron binding site [ion binding]; other site 196627000552 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 196627000553 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 196627000554 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK05597 196627000555 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 196627000556 ATP binding site [chemical binding]; other site 196627000557 substrate interface [chemical binding]; other site 196627000558 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 196627000559 active site residue [active] 196627000560 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 196627000561 MoaE homodimer interface [polypeptide binding]; other site 196627000562 MoaD interaction [polypeptide binding]; other site 196627000563 active site residues [active] 196627000564 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 196627000565 MPT binding site; other site 196627000566 trimer interface [polypeptide binding]; other site 196627000567 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 196627000568 trimer interface [polypeptide binding]; other site 196627000569 dimer interface [polypeptide binding]; other site 196627000570 putative active site [active] 196627000571 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 196627000572 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 196627000573 dimer interface [polypeptide binding]; other site 196627000574 putative functional site; other site 196627000575 putative MPT binding site; other site 196627000576 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 196627000577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196627000578 dimer interface [polypeptide binding]; other site 196627000579 conserved gate region; other site 196627000580 putative PBP binding loops; other site 196627000581 ABC-ATPase subunit interface; other site 196627000582 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 196627000583 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 196627000584 MoaE interaction surface [polypeptide binding]; other site 196627000585 MoeB interaction surface [polypeptide binding]; other site 196627000586 thiocarboxylated glycine; other site 196627000587 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 196627000588 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 196627000589 Walker A/P-loop; other site 196627000590 ATP binding site [chemical binding]; other site 196627000591 Q-loop/lid; other site 196627000592 ABC transporter signature motif; other site 196627000593 Walker B; other site 196627000594 D-loop; other site 196627000595 H-loop/switch region; other site 196627000596 Predicted membrane protein [Function unknown]; Region: COG1950 196627000597 putative aminotransferase; Provisional; Region: PRK03321 196627000598 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 196627000599 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196627000600 homodimer interface [polypeptide binding]; other site 196627000601 catalytic residue [active] 196627000602 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 196627000603 Transcriptional regulator [Transcription]; Region: LysR; COG0583 196627000604 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 196627000605 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 196627000606 dimerization interface [polypeptide binding]; other site 196627000607 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 196627000608 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 196627000609 putative NAD(P) binding site [chemical binding]; other site 196627000610 putative substrate binding site [chemical binding]; other site 196627000611 catalytic Zn binding site [ion binding]; other site 196627000612 structural Zn binding site [ion binding]; other site 196627000613 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 196627000614 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 196627000615 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 196627000616 MgtE intracellular N domain; Region: MgtE_N; pfam03448 196627000617 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 196627000618 Divalent cation transporter; Region: MgtE; cl00786 196627000619 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 196627000620 anion transporter; Region: dass; TIGR00785 196627000621 transmembrane helices; other site 196627000622 prephenate dehydrogenase; Validated; Region: PRK06545 196627000623 prephenate dehydrogenase; Validated; Region: PRK08507 196627000624 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 196627000625 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 196627000626 nucleoside/Zn binding site; other site 196627000627 dimer interface [polypeptide binding]; other site 196627000628 catalytic motif [active] 196627000629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 196627000630 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 196627000631 MMPL family; Region: MMPL; cl14618 196627000632 MMPL family; Region: MMPL; cl14618 196627000633 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 196627000634 Queuine tRNA-ribosyltransferase; Region: TGT; cl19224 196627000635 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 196627000636 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 196627000637 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 196627000638 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196627000639 Q-loop/lid; other site 196627000640 ABC transporter signature motif; other site 196627000641 Walker B; other site 196627000642 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 196627000643 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 196627000644 active site 196627000645 nucleotide binding site [chemical binding]; other site 196627000646 HIGH motif; other site 196627000647 KMSKS motif; other site 196627000648 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 196627000649 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 196627000650 putative active site [active] 196627000651 Integrase core domain; Region: rve; pfam00665 196627000652 DDE domain; Region: DDE_Tnp_IS240; pfam13610 196627000653 Integrase core domain; Region: rve_3; pfam13683 196627000654 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 196627000655 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 196627000656 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196627000657 homodimer interface [polypeptide binding]; other site 196627000658 catalytic residue [active] 196627000659 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 196627000660 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 196627000661 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196627000662 Walker A motif; other site 196627000663 ATP binding site [chemical binding]; other site 196627000664 Walker B motif; other site 196627000665 arginine finger; other site 196627000666 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 196627000667 hypothetical protein; Validated; Region: PRK00153 196627000668 recombination protein RecR; Reviewed; Region: recR; PRK00076 196627000669 Helix-hairpin-helix motif; Region: HHH; pfam00633 196627000670 RecR protein; Region: RecR; pfam02132 196627000671 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 196627000672 putative active site [active] 196627000673 putative metal-binding site [ion binding]; other site 196627000674 tetramer interface [polypeptide binding]; other site 196627000675 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 196627000676 catalytic triad [active] 196627000677 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 196627000678 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 196627000679 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 196627000680 DNA polymerase III subunit epsilon; Validated; Region: PRK05601 196627000681 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 196627000682 active site 196627000683 substrate binding site [chemical binding]; other site 196627000684 2-isopropylmalate synthase; Validated; Region: PRK03739 196627000685 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 196627000686 active site 196627000687 catalytic residues [active] 196627000688 metal binding site [ion binding]; metal-binding site 196627000689 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 196627000690 aspartate kinase; Reviewed; Region: PRK06635 196627000691 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 196627000692 putative nucleotide binding site [chemical binding]; other site 196627000693 putative catalytic residues [active] 196627000694 putative Mg ion binding site [ion binding]; other site 196627000695 putative aspartate binding site [chemical binding]; other site 196627000696 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 196627000697 putative allosteric regulatory site; other site 196627000698 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 196627000699 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 196627000700 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 196627000701 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 196627000702 RNA polymerase sigma factor; Provisional; Region: PRK12535 196627000703 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 196627000704 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 196627000705 DNA binding residues [nucleotide binding] 196627000706 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 196627000707 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 196627000708 heme binding pocket [chemical binding]; other site 196627000709 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 196627000710 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 196627000711 putative DNA binding site [nucleotide binding]; other site 196627000712 putative Zn2+ binding site [ion binding]; other site 196627000713 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 196627000714 Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687 196627000715 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 196627000716 dimerization interface [polypeptide binding]; other site 196627000717 putative DNA binding site [nucleotide binding]; other site 196627000718 putative Zn2+ binding site [ion binding]; other site 196627000719 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 196627000720 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 196627000721 active site 196627000722 Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism]; Region: MnhG; COG1320 196627000723 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612 196627000724 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654 196627000725 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 196627000726 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 196627000727 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 196627000728 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 196627000729 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 196627000730 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 196627000731 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 196627000732 Predicted membrane protein [Function unknown]; Region: COG1511 196627000733 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 196627000734 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 196627000735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196627000736 active site 196627000737 phosphorylation site [posttranslational modification] 196627000738 intermolecular recognition site; other site 196627000739 dimerization interface [polypeptide binding]; other site 196627000740 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 196627000741 DNA binding site [nucleotide binding] 196627000742 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 196627000743 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 196627000744 dimerization interface [polypeptide binding]; other site 196627000745 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 196627000746 dimer interface [polypeptide binding]; other site 196627000747 phosphorylation site [posttranslational modification] 196627000748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196627000749 ATP binding site [chemical binding]; other site 196627000750 Mg2+ binding site [ion binding]; other site 196627000751 G-X-G motif; other site 196627000752 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 196627000753 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 196627000754 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 196627000755 putative active site [active] 196627000756 putative metal binding site [ion binding]; other site 196627000757 Yqey-like protein; Region: YqeY; pfam09424 196627000758 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 196627000759 Transglycosylase; Region: Transgly; pfam00912 196627000760 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 196627000761 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 196627000762 Transcription factor WhiB; Region: Whib; pfam02467 196627000763 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 196627000764 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 196627000765 homotrimer interaction site [polypeptide binding]; other site 196627000766 putative active site [active] 196627000767 metabolite-proton symporter; Region: 2A0106; TIGR00883 196627000768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627000769 putative substrate translocation pore; other site 196627000770 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 196627000771 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 196627000772 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 196627000773 acyl-activating enzyme (AAE) consensus motif; other site 196627000774 putative AMP binding site [chemical binding]; other site 196627000775 putative active site [active] 196627000776 putative CoA binding site [chemical binding]; other site 196627000777 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 196627000778 Transcriptional regulators [Transcription]; Region: MarR; COG1846 196627000779 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 196627000780 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196627000781 NAD(P) binding site [chemical binding]; other site 196627000782 active site 196627000783 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 196627000784 active site 196627000785 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 196627000786 acyl-coenzyme A oxidase; Region: PLN02526 196627000787 active site 196627000788 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 196627000789 putative active site [active] 196627000790 putative catalytic site [active] 196627000791 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 196627000792 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 196627000793 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 196627000794 ligand binding site [chemical binding]; other site 196627000795 flexible hinge region; other site 196627000796 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 196627000797 putative switch regulator; other site 196627000798 non-specific DNA interactions [nucleotide binding]; other site 196627000799 DNA binding site [nucleotide binding] 196627000800 sequence specific DNA binding site [nucleotide binding]; other site 196627000801 putative cAMP binding site [chemical binding]; other site 196627000802 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 196627000803 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 196627000804 minor groove reading motif; other site 196627000805 helix-hairpin-helix signature motif; other site 196627000806 substrate binding pocket [chemical binding]; other site 196627000807 active site 196627000808 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 196627000809 catalytic residues [active] 196627000810 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 196627000811 putative active site [active] 196627000812 putative CoA binding site [chemical binding]; other site 196627000813 nudix motif; other site 196627000814 metal binding site [ion binding]; metal-binding site 196627000815 Colicin V production protein; Region: Colicin_V; pfam02674 196627000816 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 196627000817 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 196627000818 Putative lysophospholipase; Region: Hydrolase_4; cl19140 196627000819 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 196627000820 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 196627000821 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 196627000822 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196627000823 motif II; other site 196627000824 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 196627000825 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 196627000826 ATP binding site [chemical binding]; other site 196627000827 Walker A motif; other site 196627000828 hexamer interface [polypeptide binding]; other site 196627000829 Walker B motif; other site 196627000830 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 196627000831 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 196627000832 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 196627000833 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 196627000834 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 196627000835 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196627000836 ATP binding site [chemical binding]; other site 196627000837 putative Mg++ binding site [ion binding]; other site 196627000838 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196627000839 nucleotide binding region [chemical binding]; other site 196627000840 ATP-binding site [chemical binding]; other site 196627000841 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 196627000842 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 196627000843 DNA-binding site [nucleotide binding]; DNA binding site 196627000844 RNA-binding motif; other site 196627000845 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 196627000846 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 196627000847 active site 196627000848 interdomain interaction site; other site 196627000849 putative metal-binding site [ion binding]; other site 196627000850 nucleotide binding site [chemical binding]; other site 196627000851 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 196627000852 domain I; other site 196627000853 DNA binding groove [nucleotide binding] 196627000854 phosphate binding site [ion binding]; other site 196627000855 domain II; other site 196627000856 domain III; other site 196627000857 nucleotide binding site [chemical binding]; other site 196627000858 catalytic site [active] 196627000859 domain IV; other site 196627000860 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 196627000861 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 196627000862 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 196627000863 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 196627000864 YhhN-like protein; Region: YhhN; pfam07947 196627000865 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 196627000866 dimerization interface [polypeptide binding]; other site 196627000867 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 196627000868 cyclase homology domain; Region: CHD; cd07302 196627000869 nucleotidyl binding site; other site 196627000870 metal binding site [ion binding]; metal-binding site 196627000871 dimer interface [polypeptide binding]; other site 196627000872 DNA polymerase III subunit delta'; Validated; Region: PRK07940 196627000873 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196627000874 Walker A motif; other site 196627000875 ATP binding site [chemical binding]; other site 196627000876 Walker B motif; other site 196627000877 arginine finger; other site 196627000878 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 196627000879 Uncharacterized phage-associated protein [Function unknown]; Region: GepA; COG3600 196627000880 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 196627000881 AAA domain; Region: AAA_17; pfam13207 196627000882 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 196627000883 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 196627000884 RNA binding surface [nucleotide binding]; other site 196627000885 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 196627000886 active site 196627000887 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 196627000888 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 196627000889 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 196627000890 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 196627000891 NAD(P) binding site [chemical binding]; other site 196627000892 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 196627000893 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 196627000894 classical (c) SDRs; Region: SDR_c; cd05233 196627000895 NAD(P) binding site [chemical binding]; other site 196627000896 active site 196627000897 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627000898 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196627000899 putative substrate translocation pore; other site 196627000900 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 196627000901 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196627000902 NAD(P) binding site [chemical binding]; other site 196627000903 active site 196627000904 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 196627000905 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 196627000906 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 196627000907 Ligand binding site; other site 196627000908 Putative Catalytic site; other site 196627000909 DXD motif; other site 196627000910 Ribonuclease HI [DNA replication, recombination, and repair]; Region: RnhA; COG0328 196627000911 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 196627000912 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 196627000913 Probable Catalytic site; other site 196627000914 metal-binding site 196627000915 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 196627000916 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 196627000917 putative active site [active] 196627000918 putative metal binding site [ion binding]; other site 196627000919 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 196627000920 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 196627000921 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 196627000922 putative NAD(P) binding site [chemical binding]; other site 196627000923 putative substrate binding site [chemical binding]; other site 196627000924 catalytic Zn binding site [ion binding]; other site 196627000925 structural Zn binding site [ion binding]; other site 196627000926 dimer interface [polypeptide binding]; other site 196627000927 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 196627000928 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 196627000929 substrate binding site; other site 196627000930 tetramer interface; other site 196627000931 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 196627000932 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 196627000933 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 196627000934 NADP binding site [chemical binding]; other site 196627000935 active site 196627000936 putative substrate binding site [chemical binding]; other site 196627000937 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 196627000938 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 196627000939 NAD binding site [chemical binding]; other site 196627000940 substrate binding site [chemical binding]; other site 196627000941 homodimer interface [polypeptide binding]; other site 196627000942 active site 196627000943 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370 196627000944 dimer interface [polypeptide binding]; other site 196627000945 FMN binding site [chemical binding]; other site 196627000946 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 196627000947 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 196627000948 siderophore binding site; other site 196627000949 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 196627000950 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 196627000951 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 196627000952 Zn binding site [ion binding]; other site 196627000953 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 196627000954 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 196627000955 Excalibur calcium-binding domain; Region: Excalibur; smart00894 196627000956 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 196627000957 Predicted esterase [General function prediction only]; Region: COG0627 196627000958 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 196627000959 Chain length determinant protein; Region: Wzz; pfam02706 196627000960 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 196627000961 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 196627000962 AAA domain; Region: AAA_31; pfam13614 196627000963 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 196627000964 active site 196627000965 VPS10 domain; Region: VPS10; smart00602 196627000966 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 196627000967 CoA binding domain; Region: CoA_binding; cl17356 196627000968 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 196627000969 NAD(P) binding site [chemical binding]; other site 196627000970 homodimer interface [polypeptide binding]; other site 196627000971 substrate binding site [chemical binding]; other site 196627000972 active site 196627000973 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 196627000974 inhibitor-cofactor binding pocket; inhibition site 196627000975 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196627000976 catalytic residue [active] 196627000977 Bacterial sugar transferase; Region: Bac_transf; pfam02397 196627000978 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 196627000979 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 196627000980 putative ADP-binding pocket [chemical binding]; other site 196627000981 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 196627000982 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 196627000983 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 196627000984 hinge; other site 196627000985 active site 196627000986 UDP-N-acetylmuramate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: MurB; COG0812 196627000987 FAD binding domain; Region: FAD_binding_4; pfam01565 196627000988 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 196627000989 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 196627000990 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 196627000991 active site 196627000992 Acyltransferase family; Region: Acyl_transf_3; cl19154 196627000993 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 196627000994 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 196627000995 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 196627000996 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 196627000997 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 196627000998 O-Antigen ligase; Region: Wzy_C; pfam04932 196627000999 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 196627001000 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 196627001001 active site 196627001002 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 196627001003 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 196627001004 putative trimer interface [polypeptide binding]; other site 196627001005 putative CoA binding site [chemical binding]; other site 196627001006 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 196627001007 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 196627001008 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 196627001009 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 196627001010 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 196627001011 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 196627001012 active site 196627001013 tetramer interface; other site 196627001014 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 196627001015 putative deacylase active site [active] 196627001016 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 196627001017 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196627001018 non-specific DNA binding site [nucleotide binding]; other site 196627001019 salt bridge; other site 196627001020 sequence-specific DNA binding site [nucleotide binding]; other site 196627001021 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 196627001022 Domain of unknown function (DUF955); Region: DUF955; pfam06114 196627001023 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 196627001024 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 196627001025 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 196627001026 putative Iron-sulfur protein interface [polypeptide binding]; other site 196627001027 proximal heme binding site [chemical binding]; other site 196627001028 distal heme binding site [chemical binding]; other site 196627001029 putative dimer interface [polypeptide binding]; other site 196627001030 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 196627001031 L-aspartate oxidase; Provisional; Region: PRK06175 196627001032 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 196627001033 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 196627001034 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 196627001035 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 196627001036 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 196627001037 Winged helix DNA-binding domain; Region: HTH_42; pfam06224 196627001038 Predicted membrane protein [Function unknown]; Region: COG2733 196627001039 Protein of unknown function (DUF445); Region: DUF445; pfam04286 196627001040 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 196627001041 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 196627001042 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 196627001043 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627001044 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196627001045 putative substrate translocation pore; other site 196627001046 K+-transporting ATPase, c chain; Region: KdpC; cl00944 196627001047 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627001048 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196627001049 putative substrate translocation pore; other site 196627001050 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 196627001051 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 196627001052 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 196627001053 putative active site [active] 196627001054 putative substrate binding site [chemical binding]; other site 196627001055 putative cosubstrate binding site; other site 196627001056 catalytic site [active] 196627001057 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 196627001058 intersubunit interface [polypeptide binding]; other site 196627001059 active site 196627001060 catalytic residue [active] 196627001061 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 196627001062 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 196627001063 putative homodimer interface [polypeptide binding]; other site 196627001064 putative homotetramer interface [polypeptide binding]; other site 196627001065 putative allosteric switch controlling residues; other site 196627001066 putative metal binding site [ion binding]; other site 196627001067 putative homodimer-homodimer interface [polypeptide binding]; other site 196627001068 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 196627001069 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 196627001070 metal-binding site [ion binding] 196627001071 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 196627001072 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 196627001073 Htaa; Region: HtaA; pfam04213 196627001074 Htaa; Region: HtaA; pfam04213 196627001075 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 196627001076 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 196627001077 intersubunit interface [polypeptide binding]; other site 196627001078 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 196627001079 ABC-ATPase subunit interface; other site 196627001080 dimer interface [polypeptide binding]; other site 196627001081 putative PBP binding regions; other site 196627001082 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 196627001083 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 196627001084 Walker A/P-loop; other site 196627001085 ATP binding site [chemical binding]; other site 196627001086 Q-loop/lid; other site 196627001087 ABC transporter signature motif; other site 196627001088 Walker B; other site 196627001089 D-loop; other site 196627001090 H-loop/switch region; other site 196627001091 Htaa; Region: HtaA; pfam04213 196627001092 Htaa; Region: HtaA; pfam04213 196627001093 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 196627001094 Methyltransferase domain; Region: Methyltransf_18; pfam12847 196627001095 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 196627001096 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 196627001097 FAD binding domain; Region: FAD_binding_4; pfam01565 196627001098 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 196627001099 hypothetical protein; Provisional; Region: PRK07758 196627001100 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 196627001101 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 196627001102 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 196627001103 acyl-activating enzyme (AAE) consensus motif; other site 196627001104 AMP binding site [chemical binding]; other site 196627001105 active site 196627001106 CoA binding site [chemical binding]; other site 196627001107 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 196627001108 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 196627001109 putative ADP-binding pocket [chemical binding]; other site 196627001110 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 196627001111 catalytic core [active] 196627001112 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 196627001113 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 196627001114 dimer interface [polypeptide binding]; other site 196627001115 phosphorylation site [posttranslational modification] 196627001116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196627001117 ATP binding site [chemical binding]; other site 196627001118 Mg2+ binding site [ion binding]; other site 196627001119 G-X-G motif; other site 196627001120 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 196627001121 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196627001122 active site 196627001123 phosphorylation site [posttranslational modification] 196627001124 intermolecular recognition site; other site 196627001125 dimerization interface [polypeptide binding]; other site 196627001126 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 196627001127 DNA binding site [nucleotide binding] 196627001128 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 196627001129 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 196627001130 FtsX-like permease family; Region: FtsX; pfam02687 196627001131 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 196627001132 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 196627001133 FtsX-like permease family; Region: FtsX; pfam02687 196627001134 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 196627001135 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483 196627001136 ribonuclease E; Reviewed; Region: rne; PRK10811 196627001137 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 196627001138 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 196627001139 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 196627001140 DNA binding domain, excisionase family; Region: excise; TIGR01764 196627001141 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 196627001142 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 196627001143 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 196627001144 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 196627001145 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 196627001146 tRNA; other site 196627001147 putative tRNA binding site [nucleotide binding]; other site 196627001148 putative NADP binding site [chemical binding]; other site 196627001149 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 196627001150 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 196627001151 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 196627001152 domain interfaces; other site 196627001153 active site 196627001154 Transcriptional regulator [Transcription]; Region: LysR; COG0583 196627001155 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 196627001156 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 196627001157 dimerization interface [polypeptide binding]; other site 196627001158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627001159 metabolite-proton symporter; Region: 2A0106; TIGR00883 196627001160 putative substrate translocation pore; other site 196627001161 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 196627001162 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 196627001163 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 196627001164 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 196627001165 active site 196627001166 metal binding site [ion binding]; metal-binding site 196627001167 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 196627001168 active site 196627001169 Fe binding site [ion binding]; other site 196627001170 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 196627001171 trimer interface [polypeptide binding]; other site 196627001172 active site 196627001173 dimer interface [polypeptide binding]; other site 196627001174 quinate/shikimate dehydrogenase; Provisional; Region: PRK14027 196627001175 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 196627001176 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 196627001177 shikimate binding site; other site 196627001178 NAD(P) binding site [chemical binding]; other site 196627001179 Ribosomal protein L7/L12 [Translation, ribosomal structure and biogenesis]; Region: RplL; COG0222 196627001180 L11 interface [polypeptide binding]; other site 196627001181 putative EF-Tu interaction site [polypeptide binding]; other site 196627001182 putative EF-G interaction site [polypeptide binding]; other site 196627001183 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 196627001184 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 196627001185 Walker A/P-loop; other site 196627001186 ATP binding site [chemical binding]; other site 196627001187 Q-loop/lid; other site 196627001188 ABC transporter signature motif; other site 196627001189 Walker B; other site 196627001190 D-loop; other site 196627001191 H-loop/switch region; other site 196627001192 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 196627001193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196627001194 dimer interface [polypeptide binding]; other site 196627001195 conserved gate region; other site 196627001196 putative PBP binding loops; other site 196627001197 ABC-ATPase subunit interface; other site 196627001198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196627001199 dimer interface [polypeptide binding]; other site 196627001200 conserved gate region; other site 196627001201 putative PBP binding loops; other site 196627001202 ABC-ATPase subunit interface; other site 196627001203 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate binding protein; Region: PhnS; TIGR03227 196627001204 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 196627001205 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 196627001206 active site 196627001207 homodimer interface [polypeptide binding]; other site 196627001208 SAM binding site [chemical binding]; other site 196627001209 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 196627001210 active site 196627001211 Domain of unknown function (DUF3806); Region: DUF3806; pfam12713 196627001212 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 196627001213 dimer interface [polypeptide binding]; other site 196627001214 active site 196627001215 Schiff base residues; other site 196627001216 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 196627001217 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 196627001218 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 196627001219 substrate binding site [chemical binding]; other site 196627001220 active site 196627001221 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 196627001222 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 196627001223 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 196627001224 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 196627001225 inhibitor-cofactor binding pocket; inhibition site 196627001226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196627001227 catalytic residue [active] 196627001228 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 196627001229 catalytic core [active] 196627001230 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 196627001231 catalytic residues [active] 196627001232 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 196627001233 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 196627001234 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 196627001235 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 196627001236 active site 196627001237 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 196627001238 homotrimer interaction site [polypeptide binding]; other site 196627001239 putative active site [active] 196627001240 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 196627001241 putative DNA binding site [nucleotide binding]; other site 196627001242 dimerization interface [polypeptide binding]; other site 196627001243 putative Zn2+ binding site [ion binding]; other site 196627001244 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 196627001245 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 196627001246 putative active site [active] 196627001247 acetolactate synthase catalytic subunit; Validated; Region: PRK08327 196627001248 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 196627001249 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 196627001250 acyl-activating enzyme (AAE) consensus motif; other site 196627001251 AMP binding site [chemical binding]; other site 196627001252 active site 196627001253 CoA binding site [chemical binding]; other site 196627001254 Predicted membrane protein [Function unknown]; Region: COG2259 196627001255 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 196627001256 dimer interface [polypeptide binding]; other site 196627001257 NADP binding site [chemical binding]; other site 196627001258 catalytic residues [active] 196627001259 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 196627001260 putative active site [active] 196627001261 catalytic residue [active] 196627001262 Transcriptional regulator [Transcription]; Region: LysR; COG0583 196627001263 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 196627001264 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447 196627001265 putative dimerization interface [polypeptide binding]; other site 196627001266 putative substrate binding pocket [chemical binding]; other site 196627001267 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 196627001268 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 196627001269 active site 196627001270 Predicted thioesterase [General function prediction only]; Region: COG5496 196627001271 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 196627001272 active site 1 [active] 196627001273 active site 2 [active] 196627001274 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 196627001275 Dihydroxynaphthoic acid synthase [Coenzyme metabolism]; Region: MenB; COG0447 196627001276 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 196627001277 substrate binding site [chemical binding]; other site 196627001278 oxyanion hole (OAH) forming residues; other site 196627001279 trimer interface [polypeptide binding]; other site 196627001280 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 196627001281 aromatic arch; other site 196627001282 DCoH dimer interaction site [polypeptide binding]; other site 196627001283 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 196627001284 DCoH tetramer interaction site [polypeptide binding]; other site 196627001285 substrate binding site [chemical binding]; other site 196627001286 Peptidase E [Amino acid transport and metabolism]; Region: PepE; COG3340 196627001287 conserved cys residue [active] 196627001288 O-succinylbenzoate synthase; Provisional; Region: PRK02901 196627001289 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 196627001290 active site 196627001291 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 196627001292 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 196627001293 dimer interface [polypeptide binding]; other site 196627001294 tetramer interface [polypeptide binding]; other site 196627001295 PYR/PP interface [polypeptide binding]; other site 196627001296 TPP binding site [chemical binding]; other site 196627001297 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 196627001298 TPP-binding site; other site 196627001299 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 196627001300 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 196627001301 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 196627001302 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 196627001303 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 196627001304 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 196627001305 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196627001306 S-adenosylmethionine binding site [chemical binding]; other site 196627001307 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 196627001308 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 196627001309 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 196627001310 substrate binding pocket [chemical binding]; other site 196627001311 chain length determination region; other site 196627001312 substrate-Mg2+ binding site; other site 196627001313 catalytic residues [active] 196627001314 aspartate-rich region 1; other site 196627001315 active site lid residues [active] 196627001316 aspartate-rich region 2; other site 196627001317 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 196627001318 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 196627001319 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 196627001320 putative homodimer interface [polypeptide binding]; other site 196627001321 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 196627001322 heterodimer interface [polypeptide binding]; other site 196627001323 homodimer interface [polypeptide binding]; other site 196627001324 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 196627001325 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 196627001326 23S rRNA interface [nucleotide binding]; other site 196627001327 L7/L12 interface [polypeptide binding]; other site 196627001328 putative thiostrepton binding site; other site 196627001329 L25 interface [polypeptide binding]; other site 196627001330 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 196627001331 mRNA/rRNA interface [nucleotide binding]; other site 196627001332 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 196627001333 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 196627001334 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 196627001335 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 196627001336 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 196627001337 inhibitor-cofactor binding pocket; inhibition site 196627001338 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196627001339 catalytic residue [active] 196627001340 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 196627001341 tetramerization interface [polypeptide binding]; other site 196627001342 NAD(P) binding site [chemical binding]; other site 196627001343 catalytic residues [active] 196627001344 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 196627001345 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 196627001346 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 196627001347 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 196627001348 Soluble P-type ATPase [General function prediction only]; Region: COG4087 196627001349 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 196627001350 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 196627001351 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 196627001352 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 196627001353 23S rRNA interface [nucleotide binding]; other site 196627001354 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 196627001355 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 196627001356 core dimer interface [polypeptide binding]; other site 196627001357 peripheral dimer interface [polypeptide binding]; other site 196627001358 L10 interface [polypeptide binding]; other site 196627001359 L11 interface [polypeptide binding]; other site 196627001360 putative EF-Tu interaction site [polypeptide binding]; other site 196627001361 putative EF-G interaction site [polypeptide binding]; other site 196627001362 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 196627001363 Tetraspanin family; Region: Tetraspannin; pfam00335 196627001364 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 196627001365 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 196627001366 RPB12 interaction site [polypeptide binding]; other site 196627001367 RPB1 interaction site [polypeptide binding]; other site 196627001368 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 196627001369 RPB10 interaction site [polypeptide binding]; other site 196627001370 RPB11 interaction site [polypeptide binding]; other site 196627001371 RPB3 interaction site [polypeptide binding]; other site 196627001372 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 196627001373 beta and beta' interface [polypeptide binding]; other site 196627001374 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 196627001375 beta' and sigma factor interface [polypeptide binding]; other site 196627001376 Zn-binding [ion binding]; other site 196627001377 active site region [active] 196627001378 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 196627001379 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 196627001380 catalytic site [active] 196627001381 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 196627001382 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 196627001383 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 196627001384 G-loop; other site 196627001385 DNA binding site [nucleotide binding] 196627001386 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196627001387 salt bridge; other site 196627001388 non-specific DNA binding site [nucleotide binding]; other site 196627001389 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 196627001390 sequence-specific DNA binding site [nucleotide binding]; other site 196627001391 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 196627001392 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; cl19753 196627001393 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 196627001394 S17 interaction site [polypeptide binding]; other site 196627001395 S8 interaction site; other site 196627001396 16S rRNA interaction site [nucleotide binding]; other site 196627001397 streptomycin interaction site [chemical binding]; other site 196627001398 23S rRNA interaction site [nucleotide binding]; other site 196627001399 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 196627001400 30S ribosomal protein S7; Validated; Region: PRK05302 196627001401 elongation factor G; Reviewed; Region: PRK00007 196627001402 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 196627001403 G1 box; other site 196627001404 putative GEF interaction site [polypeptide binding]; other site 196627001405 GTP/Mg2+ binding site [chemical binding]; other site 196627001406 Switch I region; other site 196627001407 G2 box; other site 196627001408 G3 box; other site 196627001409 Switch II region; other site 196627001410 G4 box; other site 196627001411 G5 box; other site 196627001412 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 196627001413 Elongation Factor G, domain II; Region: EFG_II; pfam14492 196627001414 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 196627001415 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 196627001416 elongation factor Tu; Reviewed; Region: PRK00049 196627001417 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 196627001418 G1 box; other site 196627001419 GEF interaction site [polypeptide binding]; other site 196627001420 GTP/Mg2+ binding site [chemical binding]; other site 196627001421 Switch I region; other site 196627001422 G2 box; other site 196627001423 G3 box; other site 196627001424 Switch II region; other site 196627001425 G4 box; other site 196627001426 G5 box; other site 196627001427 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 196627001428 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 196627001429 Antibiotic Binding Site [chemical binding]; other site 196627001430 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 196627001431 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 196627001432 Walker A/P-loop; other site 196627001433 ATP binding site [chemical binding]; other site 196627001434 Q-loop/lid; other site 196627001435 ABC transporter signature motif; other site 196627001436 Walker B; other site 196627001437 D-loop; other site 196627001438 H-loop/switch region; other site 196627001439 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 196627001440 ABC-ATPase subunit interface; other site 196627001441 dimer interface [polypeptide binding]; other site 196627001442 putative PBP binding regions; other site 196627001443 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 196627001444 ABC-ATPase subunit interface; other site 196627001445 dimer interface [polypeptide binding]; other site 196627001446 putative PBP binding regions; other site 196627001447 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 196627001448 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 196627001449 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 196627001450 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 196627001451 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 196627001452 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 196627001453 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 196627001454 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 196627001455 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 196627001456 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 196627001457 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 196627001458 putative translocon binding site; other site 196627001459 protein-rRNA interface [nucleotide binding]; other site 196627001460 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 196627001461 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 196627001462 G-X-X-G motif; other site 196627001463 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 196627001464 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 196627001465 23S rRNA interface [nucleotide binding]; other site 196627001466 5S rRNA interface [nucleotide binding]; other site 196627001467 putative antibiotic binding site [chemical binding]; other site 196627001468 L25 interface [polypeptide binding]; other site 196627001469 L27 interface [polypeptide binding]; other site 196627001470 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 196627001471 putative translocon interaction site; other site 196627001472 23S rRNA interface [nucleotide binding]; other site 196627001473 signal recognition particle (SRP54) interaction site; other site 196627001474 L23 interface [polypeptide binding]; other site 196627001475 trigger factor interaction site; other site 196627001476 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 196627001477 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 196627001478 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 196627001479 RNA binding site [nucleotide binding]; other site 196627001480 eIF3G domain found in eukaryotic translation initiation factor 3 subunit G (eIF-3G) and similar proteins; Region: eIF3G; cl13749 196627001481 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 196627001482 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 196627001483 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 196627001484 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 196627001485 active site 196627001486 catalytic triad [active] 196627001487 oxyanion hole [active] 196627001488 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 196627001489 active site 196627001490 catalytic tetrad [active] 196627001491 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 196627001492 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 196627001493 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 196627001494 putative molybdopterin cofactor binding site [chemical binding]; other site 196627001495 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 196627001496 putative molybdopterin cofactor binding site; other site 196627001497 Domain of unknown function (DUF4430); Region: DUF4430; pfam14478 196627001498 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 196627001499 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 196627001500 Walker A/P-loop; other site 196627001501 ATP binding site [chemical binding]; other site 196627001502 Q-loop/lid; other site 196627001503 ABC transporter signature motif; other site 196627001504 Walker B; other site 196627001505 D-loop; other site 196627001506 H-loop/switch region; other site 196627001507 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 196627001508 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196627001509 Walker A/P-loop; other site 196627001510 ATP binding site [chemical binding]; other site 196627001511 Q-loop/lid; other site 196627001512 ABC transporter signature motif; other site 196627001513 Walker B; other site 196627001514 D-loop; other site 196627001515 H-loop/switch region; other site 196627001516 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 196627001517 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 196627001518 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 196627001519 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196627001520 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 196627001521 Coenzyme A binding pocket [chemical binding]; other site 196627001522 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 196627001523 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 196627001524 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 196627001525 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 196627001526 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 196627001527 23S rRNA interface [nucleotide binding]; other site 196627001528 L21e interface [polypeptide binding]; other site 196627001529 5S rRNA interface [nucleotide binding]; other site 196627001530 L27 interface [polypeptide binding]; other site 196627001531 L5 interface [polypeptide binding]; other site 196627001532 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 196627001533 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 196627001534 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 196627001535 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 196627001536 23S rRNA binding site [nucleotide binding]; other site 196627001537 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 196627001538 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 196627001539 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 196627001540 NAD binding site [chemical binding]; other site 196627001541 catalytic residues [active] 196627001542 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 196627001543 Zn2+ binding site [ion binding]; other site 196627001544 Mg2+ binding site [ion binding]; other site 196627001545 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 196627001546 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 196627001547 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 196627001548 Reductase C-terminal; Region: Reductase_C; pfam14759 196627001549 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 196627001550 catalytic loop [active] 196627001551 iron binding site [ion binding]; other site 196627001552 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 196627001553 classical (c) SDRs; Region: SDR_c; cd05233 196627001554 NAD(P) binding site [chemical binding]; other site 196627001555 active site 196627001556 hypothetical protein; Provisional; Region: PRK08296 196627001557 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 196627001558 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 196627001559 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 196627001560 Transcriptional regulator [Transcription]; Region: IclR; COG1414 196627001561 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 196627001562 Bacterial transcriptional regulator; Region: IclR; pfam01614 196627001563 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 196627001564 SecY translocase; Region: SecY; pfam00344 196627001565 adenylate kinase; Reviewed; Region: adk; PRK00279 196627001566 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 196627001567 AMP-binding site [chemical binding]; other site 196627001568 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 196627001569 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 196627001570 active site 196627001571 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 196627001572 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 196627001573 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 196627001574 rRNA binding site [nucleotide binding]; other site 196627001575 predicted 30S ribosome binding site; other site 196627001576 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 196627001577 30S ribosomal protein S11; Validated; Region: PRK05309 196627001578 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 196627001579 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 196627001580 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 196627001581 RNA binding surface [nucleotide binding]; other site 196627001582 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 196627001583 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 196627001584 alphaNTD - beta interaction site [polypeptide binding]; other site 196627001585 alphaNTD homodimer interface [polypeptide binding]; other site 196627001586 alphaNTD - beta' interaction site [polypeptide binding]; other site 196627001587 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 196627001588 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 196627001589 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 196627001590 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 196627001591 dimerization interface 3.5A [polypeptide binding]; other site 196627001592 active site 196627001593 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196627001594 Coenzyme A binding pocket [chemical binding]; other site 196627001595 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 196627001596 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 196627001597 FAD binding domain; Region: FAD_binding_4; pfam01565 196627001598 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 196627001599 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 196627001600 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196627001601 S-adenosylmethionine binding site [chemical binding]; other site 196627001602 TIGR02611 family protein; Region: TIGR02611 196627001603 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 196627001604 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 196627001605 active site 196627001606 catalytic residues [active] 196627001607 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 196627001608 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 196627001609 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 196627001610 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 196627001611 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 196627001612 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 196627001613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 196627001614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 196627001615 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 196627001616 23S rRNA interface [nucleotide binding]; other site 196627001617 L3 interface [polypeptide binding]; other site 196627001618 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 196627001619 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 196627001620 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 196627001621 active site 196627001622 substrate binding site [chemical binding]; other site 196627001623 metal binding site [ion binding]; metal-binding site 196627001624 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 196627001625 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 196627001626 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 196627001627 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 196627001628 alanine racemase; Reviewed; Region: alr; PRK00053 196627001629 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 196627001630 active site 196627001631 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 196627001632 dimer interface [polypeptide binding]; other site 196627001633 substrate binding site [chemical binding]; other site 196627001634 catalytic residues [active] 196627001635 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 196627001636 Predicted permease [General function prediction only]; Region: COG2985 196627001637 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 196627001638 TrkA-C domain; Region: TrkA_C; pfam02080 196627001639 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 196627001640 Putative lysophospholipase; Region: Hydrolase_4; cl19140 196627001641 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 196627001642 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 196627001643 Glycoprotease family; Region: Peptidase_M22; pfam00814 196627001644 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 196627001645 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196627001646 Coenzyme A binding pocket [chemical binding]; other site 196627001647 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 196627001648 UGMP family protein; Validated; Region: PRK09604 196627001649 Uncharacterized conserved protein [Function unknown]; Region: COG0062 196627001650 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 196627001651 putative substrate binding site [chemical binding]; other site 196627001652 putative ATP binding site [chemical binding]; other site 196627001653 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 196627001654 oligomerisation interface [polypeptide binding]; other site 196627001655 mobile loop; other site 196627001656 roof hairpin; other site 196627001657 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 196627001658 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 196627001659 ring oligomerisation interface [polypeptide binding]; other site 196627001660 ATP/Mg binding site [chemical binding]; other site 196627001661 stacking interactions; other site 196627001662 hinge regions; other site 196627001663 Transcription factor WhiB; Region: Whib; pfam02467 196627001664 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 196627001665 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 196627001666 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 196627001667 DNA binding residues [nucleotide binding] 196627001668 Predicted solute binding protein [General function prediction only]; Region: COG3889 196627001669 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 196627001670 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 196627001671 active site 196627001672 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 196627001673 IMP dehydrogenase family protein; Region: IMP_DH_rel_2; TIGR01304 196627001674 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 196627001675 phosphate binding site [ion binding]; other site 196627001676 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 196627001677 EamA-like transporter family; Region: EamA; pfam00892 196627001678 Transcriptional regulator [Transcription]; Region: LysR; COG0583 196627001679 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 196627001680 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 196627001681 dimerization interface [polypeptide binding]; other site 196627001682 GMP synthase; Reviewed; Region: guaA; PRK00074 196627001683 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 196627001684 AMP/PPi binding site [chemical binding]; other site 196627001685 candidate oxyanion hole; other site 196627001686 catalytic triad [active] 196627001687 potential glutamine specificity residues [chemical binding]; other site 196627001688 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 196627001689 ATP Binding subdomain [chemical binding]; other site 196627001690 Ligand Binding sites [chemical binding]; other site 196627001691 Dimerization subdomain; other site 196627001692 Immunity protein 41; Region: Imm41; pfam15583 196627001693 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 196627001694 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; cl19753 196627001695 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 196627001696 Cytochrome oxidase subunit II; Region: Cyto_ox_2; cl12219 196627001697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196627001698 ATP binding site [chemical binding]; other site 196627001699 Mg2+ binding site [ion binding]; other site 196627001700 G-X-G motif; other site 196627001701 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 196627001702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196627001703 active site 196627001704 phosphorylation site [posttranslational modification] 196627001705 intermolecular recognition site; other site 196627001706 dimerization interface [polypeptide binding]; other site 196627001707 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 196627001708 DNA binding residues [nucleotide binding] 196627001709 dimerization interface [polypeptide binding]; other site 196627001710 DNA Polymerase Y-family; Region: PolY_like; cd03468 196627001711 active site 196627001712 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 196627001713 DNA binding site [nucleotide binding] 196627001714 similar to Brevibacterium flavum carotenoid biosynthesis gene cluster encoded by GenBank Accession Number AF159510 196627001715 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 196627001716 putative dimer interface [polypeptide binding]; other site 196627001717 putative [2Fe-2S] cluster binding site [ion binding]; other site 196627001718 UbiA family of prenyltransferases (PTases), Unknown subgroup; Region: PT_UbiA_4; cd13966 196627001719 putative active site [active] 196627001720 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 196627001721 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 196627001722 phytoene desaturase; Region: crtI_fam; TIGR02734 196627001723 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 196627001724 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 196627001725 active site lid residues [active] 196627001726 substrate binding pocket [chemical binding]; other site 196627001727 catalytic residues [active] 196627001728 substrate-Mg2+ binding site; other site 196627001729 aspartate-rich region 1; other site 196627001730 aspartate-rich region 2; other site 196627001731 Transport protein; Region: actII; TIGR00833 196627001732 MMPL family; Region: MMPL; cl14618 196627001733 MMPL family; Region: MMPL; cl14618 196627001734 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 196627001735 substrate binding pocket [chemical binding]; other site 196627001736 chain length determination region; other site 196627001737 substrate-Mg2+ binding site; other site 196627001738 catalytic residues [active] 196627001739 aspartate-rich region 1; other site 196627001740 active site lid residues [active] 196627001741 aspartate-rich region 2; other site 196627001742 Transcriptional regulators [Transcription]; Region: MarR; COG1846 196627001743 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 196627001744 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 196627001745 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 196627001746 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196627001747 NAD(P) binding site [chemical binding]; other site 196627001748 active site 196627001749 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 196627001750 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 196627001751 DNA photolyase; Region: DNA_photolyase; pfam00875 196627001752 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 196627001753 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 196627001754 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 196627001755 active site 196627001756 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 196627001757 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 196627001758 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 196627001759 FtsX-like permease family; Region: FtsX; pfam02687 196627001760 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 196627001761 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 196627001762 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 196627001763 Walker A/P-loop; other site 196627001764 ATP binding site [chemical binding]; other site 196627001765 Q-loop/lid; other site 196627001766 ABC transporter signature motif; other site 196627001767 Walker B; other site 196627001768 D-loop; other site 196627001769 H-loop/switch region; other site 196627001770 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196627001771 dimer interface [polypeptide binding]; other site 196627001772 conserved gate region; other site 196627001773 ABC-ATPase subunit interface; other site 196627001774 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 196627001775 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 196627001776 Walker A/P-loop; other site 196627001777 ATP binding site [chemical binding]; other site 196627001778 Q-loop/lid; other site 196627001779 ABC transporter signature motif; other site 196627001780 Walker B; other site 196627001781 D-loop; other site 196627001782 H-loop/switch region; other site 196627001783 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 196627001784 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 196627001785 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 196627001786 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 196627001787 active site 196627001788 PHP Thumb interface [polypeptide binding]; other site 196627001789 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 196627001790 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 196627001791 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 196627001792 generic binding surface II; other site 196627001793 generic binding surface I; other site 196627001794 Uncharacterized conserved protein [Function unknown]; Region: COG3402 196627001795 Predicted membrane protein [Function unknown]; Region: COG3428 196627001796 Bacterial PH domain; Region: bPH_2; pfam03703 196627001797 Bacterial PH domain; Region: bPH_2; pfam03703 196627001798 Bacterial PH domain; Region: bPH_2; pfam03703 196627001799 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 196627001800 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 196627001801 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 196627001802 FeoA domain; Region: FeoA; pfam04023 196627001803 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 196627001804 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 196627001805 NAD+ binding site [chemical binding]; other site 196627001806 substrate binding site [chemical binding]; other site 196627001807 Zn binding site [ion binding]; other site 196627001808 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 196627001809 nucleoside/Zn binding site; other site 196627001810 dimer interface [polypeptide binding]; other site 196627001811 catalytic motif [active] 196627001812 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 196627001813 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 196627001814 siderophore binding site; other site 196627001815 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 196627001816 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 196627001817 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 196627001818 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 196627001819 homodimer interface [polypeptide binding]; other site 196627001820 NADP binding site [chemical binding]; other site 196627001821 substrate binding site [chemical binding]; other site 196627001822 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 196627001823 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 196627001824 Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_flotillin; cd03399 196627001825 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 196627001826 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 196627001827 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 196627001828 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 196627001829 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 196627001830 homodimer interface [polypeptide binding]; other site 196627001831 substrate-cofactor binding pocket; other site 196627001832 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196627001833 catalytic residue [active] 196627001834 carbon starvation protein A; Provisional; Region: PRK15015 196627001835 Carbon starvation protein CstA; Region: CstA; pfam02554 196627001836 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 196627001837 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 196627001838 tetramer interface [polypeptide binding]; other site 196627001839 active site 196627001840 Mg2+/Mn2+ binding site [ion binding]; other site 196627001841 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 196627001842 Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111 196627001843 dimer interface [polypeptide binding]; other site 196627001844 active site 196627001845 citrylCoA binding site [chemical binding]; other site 196627001846 oxalacetate/citrate binding site [chemical binding]; other site 196627001847 coenzyme A binding site [chemical binding]; other site 196627001848 catalytic triad [active] 196627001849 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 196627001850 Transcriptional regulators [Transcription]; Region: GntR; COG1802 196627001851 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 196627001852 DNA-binding site [nucleotide binding]; DNA binding site 196627001853 FCD domain; Region: FCD; pfam07729 196627001854 isocitrate dehydrogenase, NADP-dependent, monomeric type; Region: monomer_idh; TIGR00178 196627001855 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 196627001856 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 196627001857 FAD binding pocket [chemical binding]; other site 196627001858 FAD binding motif [chemical binding]; other site 196627001859 phosphate binding motif [ion binding]; other site 196627001860 NAD binding pocket [chemical binding]; other site 196627001861 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 196627001862 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 196627001863 Walker A/P-loop; other site 196627001864 ATP binding site [chemical binding]; other site 196627001865 Q-loop/lid; other site 196627001866 ABC transporter signature motif; other site 196627001867 Walker B; other site 196627001868 D-loop; other site 196627001869 H-loop/switch region; other site 196627001870 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 196627001871 ABC-ATPase subunit interface; other site 196627001872 dimer interface [polypeptide binding]; other site 196627001873 putative PBP binding regions; other site 196627001874 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 196627001875 ABC-ATPase subunit interface; other site 196627001876 dimer interface [polypeptide binding]; other site 196627001877 putative PBP binding regions; other site 196627001878 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 196627001879 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 196627001880 siderophore binding site; other site 196627001881 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 196627001882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627001883 putative substrate translocation pore; other site 196627001884 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 196627001885 putative catalytic site [active] 196627001886 putative metal binding site [ion binding]; other site 196627001887 putative phosphate binding site [ion binding]; other site 196627001888 Predicted membrane protein [Function unknown]; Region: COG2860 196627001889 UPF0126 domain; Region: UPF0126; pfam03458 196627001890 UPF0126 domain; Region: UPF0126; pfam03458 196627001891 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 196627001892 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 196627001893 putative ligand binding site [chemical binding]; other site 196627001894 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 196627001895 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 196627001896 Walker A/P-loop; other site 196627001897 ATP binding site [chemical binding]; other site 196627001898 Q-loop/lid; other site 196627001899 ABC transporter signature motif; other site 196627001900 Walker B; other site 196627001901 D-loop; other site 196627001902 H-loop/switch region; other site 196627001903 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 196627001904 ABC-ATPase subunit interface; other site 196627001905 dimer interface [polypeptide binding]; other site 196627001906 putative PBP binding regions; other site 196627001907 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 196627001908 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 196627001909 active site 196627001910 HIGH motif; other site 196627001911 dimer interface [polypeptide binding]; other site 196627001912 KMSKS motif; other site 196627001913 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 196627001914 RDD family; Region: RDD; pfam06271 196627001915 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 196627001916 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 196627001917 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 196627001918 NlpC/P60 family; Region: NLPC_P60; pfam00877 196627001919 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 196627001920 active site 196627001921 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 196627001922 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196627001923 non-specific DNA binding site [nucleotide binding]; other site 196627001924 salt bridge; other site 196627001925 sequence-specific DNA binding site [nucleotide binding]; other site 196627001926 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 196627001927 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 196627001928 active site 196627001929 substrate binding site [chemical binding]; other site 196627001930 metal binding site [ion binding]; metal-binding site 196627001931 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 196627001932 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 196627001933 metal binding site [ion binding]; metal-binding site 196627001934 putative dimer interface [polypeptide binding]; other site 196627001935 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 196627001936 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 196627001937 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 196627001938 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 196627001939 pyruvate carboxylase; Reviewed; Region: PRK12999 196627001940 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 196627001941 ATP-grasp domain; Region: ATP-grasp_4; cl17255 196627001942 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 196627001943 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 196627001944 active site 196627001945 catalytic residues [active] 196627001946 metal binding site [ion binding]; metal-binding site 196627001947 homodimer binding site [polypeptide binding]; other site 196627001948 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 196627001949 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 196627001950 carboxyltransferase (CT) interaction site; other site 196627001951 biotinylation site [posttranslational modification]; other site 196627001952 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 196627001953 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 196627001954 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 196627001955 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 196627001956 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 196627001957 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 196627001958 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 196627001959 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 196627001960 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 196627001961 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 196627001962 tetramer interface [polypeptide binding]; other site 196627001963 active site 196627001964 Mg2+/Mn2+ binding site [ion binding]; other site 196627001965 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 196627001966 Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111 196627001967 dimer interface [polypeptide binding]; other site 196627001968 active site 196627001969 citrylCoA binding site [chemical binding]; other site 196627001970 oxalacetate/citrate binding site [chemical binding]; other site 196627001971 coenzyme A binding site [chemical binding]; other site 196627001972 catalytic triad [active] 196627001973 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 196627001974 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196627001975 non-specific DNA binding site [nucleotide binding]; other site 196627001976 salt bridge; other site 196627001977 sequence-specific DNA binding site [nucleotide binding]; other site 196627001978 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 196627001979 Domain of unknown function (DUF955); Region: DUF955; pfam06114 196627001980 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 196627001981 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 196627001982 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 196627001983 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 196627001984 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 196627001985 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 196627001986 carboxyltransferase (CT) interaction site; other site 196627001987 biotinylation site [posttranslational modification]; other site 196627001988 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 196627001989 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 196627001990 active site residue [active] 196627001991 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 196627001992 active site residue [active] 196627001993 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 196627001994 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 196627001995 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 196627001996 active site 196627001997 dimer interface [polypeptide binding]; other site 196627001998 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 196627001999 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 196627002000 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 196627002001 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 196627002002 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 196627002003 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 196627002004 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 196627002005 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 196627002006 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 196627002007 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 196627002008 ATP-grasp domain; Region: ATP-grasp; pfam02222 196627002009 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 196627002010 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 196627002011 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 196627002012 putative active site [active] 196627002013 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 196627002014 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 196627002015 active site 196627002016 non-prolyl cis peptide bond; other site 196627002017 Winged helix-turn helix; Region: HTH_29; pfam13551 196627002018 Helix-turn-helix domain; Region: HTH_28; pfam13518 196627002019 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 196627002020 Integrase core domain; Region: rve; pfam00665 196627002021 Integrase core domain; Region: rve_3; pfam13683 196627002022 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 196627002023 putative beta-ketoacyl acyl carrier protein [ACP]reductase (BKR), subgroup 2, classical (c) SDR; Region: BKR_2_SDR_c; cd05349 196627002024 putative NAD(P) binding site [chemical binding]; other site 196627002025 active site 196627002026 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 196627002027 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 196627002028 NADP+ binding site [chemical binding]; other site 196627002029 folate binding site [chemical binding]; other site 196627002030 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 196627002031 putative dimer interface [polypeptide binding]; other site 196627002032 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729 196627002033 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 196627002034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196627002035 dimer interface [polypeptide binding]; other site 196627002036 conserved gate region; other site 196627002037 putative PBP binding loops; other site 196627002038 ABC-ATPase subunit interface; other site 196627002039 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 196627002040 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196627002041 dimer interface [polypeptide binding]; other site 196627002042 conserved gate region; other site 196627002043 putative PBP binding loops; other site 196627002044 ABC-ATPase subunit interface; other site 196627002045 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901 196627002046 putative hydrophobic ligand binding site [chemical binding]; other site 196627002047 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 196627002048 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 196627002049 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 196627002050 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 196627002051 Walker A/P-loop; other site 196627002052 ATP binding site [chemical binding]; other site 196627002053 Q-loop/lid; other site 196627002054 ABC transporter signature motif; other site 196627002055 Walker B; other site 196627002056 D-loop; other site 196627002057 H-loop/switch region; other site 196627002058 TOBE domain; Region: TOBE_2; pfam08402 196627002059 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 196627002060 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 196627002061 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 196627002062 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196627002063 ATP binding site [chemical binding]; other site 196627002064 putative Mg++ binding site [ion binding]; other site 196627002065 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196627002066 ATP-binding site [chemical binding]; other site 196627002067 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 196627002068 TIGR03089 family protein; Region: TIGR03089 196627002069 Uncharacterized conserved protein [Function unknown]; Region: COG1479 196627002070 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 196627002071 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 196627002072 Part of AAA domain; Region: AAA_19; pfam13245 196627002073 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 196627002074 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 196627002075 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196627002076 ATP binding site [chemical binding]; other site 196627002077 putative Mg++ binding site [ion binding]; other site 196627002078 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130 196627002079 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196627002080 ATP-binding site [chemical binding]; other site 196627002081 Troponin; Region: Troponin; pfam00992 196627002082 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 196627002083 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 196627002084 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 196627002085 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196627002086 ATP binding site [chemical binding]; other site 196627002087 putative Mg++ binding site [ion binding]; other site 196627002088 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196627002089 nucleotide binding region [chemical binding]; other site 196627002090 ATP-binding site [chemical binding]; other site 196627002091 Transcriptional regulator [Transcription]; Region: LytR; COG1316 196627002092 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 196627002093 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 196627002094 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 196627002095 Probable Catalytic site; other site 196627002096 metal-binding site 196627002097 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 196627002098 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 196627002099 active site 196627002100 Substrate binding site; other site 196627002101 Mg++ binding site; other site 196627002102 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 196627002103 putative trimer interface [polypeptide binding]; other site 196627002104 putative CoA binding site [chemical binding]; other site 196627002105 Transcription factor WhiB; Region: Whib; pfam02467 196627002106 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 196627002107 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 196627002108 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 196627002109 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 196627002110 active site 196627002111 substrate binding site [chemical binding]; other site 196627002112 metal binding site [ion binding]; metal-binding site 196627002113 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057 196627002114 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 196627002115 variable surface protein Vir28; Provisional; Region: PTZ00249 196627002116 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 196627002117 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 196627002118 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 196627002119 homotetramer interface [polypeptide binding]; other site 196627002120 ligand binding site [chemical binding]; other site 196627002121 catalytic site [active] 196627002122 NAD binding site [chemical binding]; other site 196627002123 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 196627002124 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 196627002125 TMP-binding site; other site 196627002126 ATP-binding site [chemical binding]; other site 196627002127 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 196627002128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196627002129 active site 196627002130 phosphorylation site [posttranslational modification] 196627002131 intermolecular recognition site; other site 196627002132 dimerization interface [polypeptide binding]; other site 196627002133 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 196627002134 DNA binding site [nucleotide binding] 196627002135 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 196627002136 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 196627002137 dimerization interface [polypeptide binding]; other site 196627002138 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 196627002139 dimer interface [polypeptide binding]; other site 196627002140 phosphorylation site [posttranslational modification] 196627002141 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196627002142 ATP binding site [chemical binding]; other site 196627002143 Mg2+ binding site [ion binding]; other site 196627002144 G-X-G motif; other site 196627002145 lipoprotein LpqB; Provisional; Region: PRK13616 196627002146 Sporulation and spore germination; Region: Germane; pfam10646 196627002147 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 196627002148 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 196627002149 active site 196627002150 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 196627002151 30S subunit binding site; other site 196627002152 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 196627002153 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196627002154 ATP binding site [chemical binding]; other site 196627002155 putative Mg++ binding site [ion binding]; other site 196627002156 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 196627002157 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196627002158 nucleotide binding region [chemical binding]; other site 196627002159 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 196627002160 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 196627002161 Predicted GTPases [General function prediction only]; Region: COG1162 196627002162 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 196627002163 GTPase/Zn-binding domain interface [polypeptide binding]; other site 196627002164 GTP/Mg2+ binding site [chemical binding]; other site 196627002165 G4 box; other site 196627002166 G5 box; other site 196627002167 G1 box; other site 196627002168 Switch I region; other site 196627002169 G2 box; other site 196627002170 G3 box; other site 196627002171 Switch II region; other site 196627002172 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 196627002173 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 196627002174 hinge; other site 196627002175 active site 196627002176 Uncharacterized conserved protein [Function unknown]; Region: COG2135 196627002177 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 196627002178 active site 196627002179 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 196627002180 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 196627002181 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 196627002182 DNA binding residues [nucleotide binding] 196627002183 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 196627002184 Transcription factor WhiB; Region: Whib; pfam02467 196627002185 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 196627002186 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 196627002187 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 196627002188 ATP binding site [chemical binding]; other site 196627002189 Mg++ binding site [ion binding]; other site 196627002190 motif III; other site 196627002191 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196627002192 nucleotide binding region [chemical binding]; other site 196627002193 ATP-binding site [chemical binding]; other site 196627002194 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 196627002195 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 196627002196 TIGR02569 family protein; Region: TIGR02569_actnb 196627002197 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 196627002198 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 196627002199 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 196627002200 Part of AAA domain; Region: AAA_19; pfam13245 196627002201 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 196627002202 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 196627002203 Ion channel; Region: Ion_trans_2; pfam07885 196627002204 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 196627002205 TrkA-N domain; Region: TrkA_N; pfam02254 196627002206 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 196627002207 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 196627002208 putative NADH binding site [chemical binding]; other site 196627002209 putative active site [active] 196627002210 nudix motif; other site 196627002211 putative metal binding site [ion binding]; other site 196627002212 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 196627002213 Part of AAA domain; Region: AAA_19; pfam13245 196627002214 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 196627002215 HRDC domain; Region: HRDC; pfam00570 196627002216 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 196627002217 Uncharacterized conserved protein [Function unknown]; Region: COG5282 196627002218 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 196627002219 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 196627002220 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 196627002221 hypothetical protein; Validated; Region: PRK00068 196627002222 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 196627002223 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 196627002224 DNA-binding site [nucleotide binding]; DNA binding site 196627002225 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 196627002226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196627002227 homodimer interface [polypeptide binding]; other site 196627002228 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 196627002229 active site 196627002230 multimer interface [polypeptide binding]; other site 196627002231 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 196627002232 predicted active site [active] 196627002233 catalytic triad [active] 196627002234 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 196627002235 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 196627002236 substrate binding sites [chemical binding]; other site 196627002237 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 196627002238 LGFP repeat; Region: LGFP; pfam08310 196627002239 LGFP repeat; Region: LGFP; pfam08310 196627002240 LGFP repeat; Region: LGFP; pfam08310 196627002241 histidinol-phosphatase, inositol monophosphatase family; Region: his_9_HisN; TIGR02067 196627002242 active site 196627002243 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 196627002244 active site 196627002245 peptide chain release factor 2; Validated; Region: prfB; PRK00578 196627002246 This domain is found in peptide chain release factors; Region: PCRF; smart00937 196627002247 RF-1 domain; Region: RF-1; pfam00472 196627002248 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 196627002249 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196627002250 Walker A/P-loop; other site 196627002251 ATP binding site [chemical binding]; other site 196627002252 Q-loop/lid; other site 196627002253 ABC transporter signature motif; other site 196627002254 Walker B; other site 196627002255 D-loop; other site 196627002256 H-loop/switch region; other site 196627002257 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 196627002258 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 196627002259 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 196627002260 SmpB-tmRNA interface; other site 196627002261 Uncharacterized conserved protein [Function unknown]; Region: COG3189 196627002262 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 196627002263 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 196627002264 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 196627002265 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 196627002266 FAD binding pocket [chemical binding]; other site 196627002267 FAD binding motif [chemical binding]; other site 196627002268 phosphate binding motif [ion binding]; other site 196627002269 NAD binding pocket [chemical binding]; other site 196627002270 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 196627002271 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 196627002272 siderophore binding site; other site 196627002273 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 196627002274 putative active site [active] 196627002275 redox center [active] 196627002276 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 196627002277 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 196627002278 intersubunit interface [polypeptide binding]; other site 196627002279 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 196627002280 ABC-ATPase subunit interface; other site 196627002281 dimer interface [polypeptide binding]; other site 196627002282 putative PBP binding regions; other site 196627002283 ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism]; Region: CeuC; COG4605 196627002284 ABC-ATPase subunit interface; other site 196627002285 dimer interface [polypeptide binding]; other site 196627002286 putative PBP binding regions; other site 196627002287 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 196627002288 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 196627002289 Walker A/P-loop; other site 196627002290 ATP binding site [chemical binding]; other site 196627002291 Q-loop/lid; other site 196627002292 ABC transporter signature motif; other site 196627002293 Walker B; other site 196627002294 D-loop; other site 196627002295 H-loop/switch region; other site 196627002296 aminotransferase; Validated; Region: PRK07777 196627002297 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 196627002298 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196627002299 homodimer interface [polypeptide binding]; other site 196627002300 catalytic residue [active] 196627002301 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 196627002302 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 196627002303 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 196627002304 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196627002305 ATP binding site [chemical binding]; other site 196627002306 putative Mg++ binding site [ion binding]; other site 196627002307 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196627002308 nucleotide binding region [chemical binding]; other site 196627002309 ATP-binding site [chemical binding]; other site 196627002310 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 196627002311 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 196627002312 Protein of unknown function (DUF3235); Region: DUF3235; pfam11574 196627002313 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 196627002314 DNA-binding site [nucleotide binding]; DNA binding site 196627002315 RNA-binding motif; other site 196627002316 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 196627002317 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 196627002318 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 196627002319 substrate-cofactor binding pocket; other site 196627002320 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196627002321 catalytic residue [active] 196627002322 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 196627002323 Sulfate transporter family; Region: Sulfate_transp; cl19250 196627002324 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 196627002325 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 196627002326 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 196627002327 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 196627002328 phosphoserine aminotransferase, putative; Region: serC_3; TIGR01366 196627002329 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 196627002330 catalytic residue [active] 196627002331 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 196627002332 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 196627002333 dimer interface [polypeptide binding]; other site 196627002334 active site 196627002335 citrylCoA binding site [chemical binding]; other site 196627002336 NADH binding [chemical binding]; other site 196627002337 cationic pore residues; other site 196627002338 oxalacetate/citrate binding site [chemical binding]; other site 196627002339 coenzyme A binding site [chemical binding]; other site 196627002340 catalytic triad [active] 196627002341 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 196627002342 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 196627002343 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 196627002344 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 196627002345 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 196627002346 Predicted membrane protein [Function unknown]; Region: COG3162 196627002347 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 196627002348 Na binding site [ion binding]; other site 196627002349 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 196627002350 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 196627002351 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 196627002352 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 196627002353 phosphate binding site [ion binding]; other site 196627002354 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 196627002355 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 196627002356 active site 2 [active] 196627002357 active site 1 [active] 196627002358 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 196627002359 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 196627002360 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196627002361 NAD(P) binding site [chemical binding]; other site 196627002362 active site 196627002363 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 196627002364 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 196627002365 active site 196627002366 Septum formation; Region: Septum_form; pfam13845 196627002367 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 196627002368 hypothetical protein; Validated; Region: PRK07581 196627002369 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 196627002370 catalytic residues [active] 196627002371 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 196627002372 folate binding site [chemical binding]; other site 196627002373 NADP+ binding site [chemical binding]; other site 196627002374 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 196627002375 dimerization interface [polypeptide binding]; other site 196627002376 active site 196627002377 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 196627002378 active site 196627002379 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196627002380 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 196627002381 ATP binding site [chemical binding]; other site 196627002382 putative Mg++ binding site [ion binding]; other site 196627002383 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196627002384 nucleotide binding region [chemical binding]; other site 196627002385 ATP-binding site [chemical binding]; other site 196627002386 DEAD/H associated; Region: DEAD_assoc; pfam08494 196627002387 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 196627002388 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 196627002389 putative DNA binding site [nucleotide binding]; other site 196627002390 catalytic residue [active] 196627002391 putative H2TH interface [polypeptide binding]; other site 196627002392 putative catalytic residues [active] 196627002393 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 196627002394 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 196627002395 Predicted membrane protein [Function unknown]; Region: COG3304 196627002396 Domain of unknown function (DUF307); Region: DUF307; pfam03733 196627002397 Domain of unknown function (DUF307); Region: DUF307; pfam03733 196627002398 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 196627002399 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 196627002400 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627002401 putative substrate translocation pore; other site 196627002402 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 196627002403 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 196627002404 active site 196627002405 dimer interface [polypeptide binding]; other site 196627002406 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 196627002407 dimer interface [polypeptide binding]; other site 196627002408 active site 196627002409 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 196627002410 active site 196627002411 hypothetical protein; Provisional; Region: PRK07857 196627002412 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 196627002413 Part of AAA domain; Region: AAA_19; pfam13245 196627002414 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 196627002415 FtsX-like permease family; Region: FtsX; pfam02687 196627002416 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 196627002417 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 196627002418 Walker A/P-loop; other site 196627002419 ATP binding site [chemical binding]; other site 196627002420 Q-loop/lid; other site 196627002421 ABC transporter signature motif; other site 196627002422 Walker B; other site 196627002423 D-loop; other site 196627002424 H-loop/switch region; other site 196627002425 Predicted transcriptional regulators [Transcription]; Region: COG1695 196627002426 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 196627002427 Peptidase family M23; Region: Peptidase_M23; pfam01551 196627002428 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 196627002429 active site 196627002430 substrate binding site [chemical binding]; other site 196627002431 cosubstrate binding site; other site 196627002432 catalytic site [active] 196627002433 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 196627002434 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 196627002435 purine monophosphate binding site [chemical binding]; other site 196627002436 dimer interface [polypeptide binding]; other site 196627002437 putative catalytic residues [active] 196627002438 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 196627002439 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 196627002440 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 196627002441 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 196627002442 30S ribosomal protein S18; Provisional; Region: PRK13401 196627002443 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 196627002444 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 196627002445 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 196627002446 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 196627002447 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 196627002448 Sulfate transporter family; Region: Sulfate_transp; cl19250 196627002449 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 196627002450 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 196627002451 dimerization interface [polypeptide binding]; other site 196627002452 putative DNA binding site [nucleotide binding]; other site 196627002453 putative Zn2+ binding site [ion binding]; other site 196627002454 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 196627002455 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 196627002456 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 196627002457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196627002458 active site 196627002459 phosphorylation site [posttranslational modification] 196627002460 intermolecular recognition site; other site 196627002461 dimerization interface [polypeptide binding]; other site 196627002462 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 196627002463 DNA binding site [nucleotide binding] 196627002464 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 196627002465 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 196627002466 dimerization interface [polypeptide binding]; other site 196627002467 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 196627002468 dimer interface [polypeptide binding]; other site 196627002469 phosphorylation site [posttranslational modification] 196627002470 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196627002471 ATP binding site [chemical binding]; other site 196627002472 Mg2+ binding site [ion binding]; other site 196627002473 G-X-G motif; other site 196627002474 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 196627002475 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 196627002476 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 196627002477 protein binding site [polypeptide binding]; other site 196627002478 Molybdopterin biosynthesis enzymes [Coenzyme metabolism]; Region: MoaB; COG0521 196627002479 MPT binding site; other site 196627002480 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 196627002481 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 196627002482 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 196627002483 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 196627002484 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 196627002485 active site 196627002486 tetramer interface; other site 196627002487 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 196627002488 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 196627002489 dimer interface [polypeptide binding]; other site 196627002490 putative functional site; other site 196627002491 putative MPT binding site; other site 196627002492 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 196627002493 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 196627002494 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 196627002495 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 196627002496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627002497 putative substrate translocation pore; other site 196627002498 Predicted membrane protein [Function unknown]; Region: COG2259 196627002499 Predicted integral membrane protein [Function unknown]; Region: COG5660 196627002500 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 196627002501 Putative zinc-finger; Region: zf-HC2; pfam13490 196627002502 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 196627002503 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 196627002504 active site 196627002505 catalytic site [active] 196627002506 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 196627002507 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 196627002508 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 196627002509 putative SAM binding site [chemical binding]; other site 196627002510 putative homodimer interface [polypeptide binding]; other site 196627002511 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 196627002512 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 196627002513 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 196627002514 active site 196627002515 HIGH motif; other site 196627002516 KMSKS motif; other site 196627002517 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 196627002518 tRNA binding surface [nucleotide binding]; other site 196627002519 anticodon binding site; other site 196627002520 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 196627002521 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196627002522 ATP binding site [chemical binding]; other site 196627002523 putative Mg++ binding site [ion binding]; other site 196627002524 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196627002525 nucleotide binding region [chemical binding]; other site 196627002526 ATP-binding site [chemical binding]; other site 196627002527 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 196627002528 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 196627002529 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 196627002530 Transposase; Region: HTH_Tnp_1; cl17663 196627002531 HTH-like domain; Region: HTH_21; pfam13276 196627002532 Integrase core domain; Region: rve; pfam00665 196627002533 Transposase; Region: DDE_Tnp_ISL3; pfam01610 196627002534 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 196627002535 D-lactate dehydrogenase; Provisional; Region: PRK11183 196627002536 FAD binding domain; Region: FAD_binding_4; cl19922 196627002537 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 196627002538 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 196627002539 DNA methylase; Region: N6_N4_Mtase; cl17433 196627002540 Transposase; Region: HTH_Tnp_1; cl17663 196627002541 HTH-like domain; Region: HTH_21; pfam13276 196627002542 Integrase core domain; Region: rve; pfam00665 196627002543 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 196627002544 dimerization interface [polypeptide binding]; other site 196627002545 putative DNA binding site [nucleotide binding]; other site 196627002546 putative Zn2+ binding site [ion binding]; other site 196627002547 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 196627002548 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 196627002549 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 196627002550 active site 196627002551 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 196627002552 Domain of unknown function (DUF348); Region: DUF348; pfam03990 196627002553 Domain of unknown function (DUF348); Region: DUF348; pfam03990 196627002554 G5 domain; Region: G5; pfam07501 196627002555 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 196627002556 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196627002557 S-adenosylmethionine binding site [chemical binding]; other site 196627002558 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 196627002559 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 196627002560 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 196627002561 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 196627002562 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 196627002563 ABC transporter; Region: ABC_tran_2; pfam12848 196627002564 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 196627002565 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 196627002566 dimer interface [polypeptide binding]; other site 196627002567 pyridoxal binding site [chemical binding]; other site 196627002568 ATP binding site [chemical binding]; other site 196627002569 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 196627002570 catalytic residues [active] 196627002571 Uncharacterized conserved protein [Function unknown]; Region: COG1359 196627002572 Uncharacterized conserved protein [Function unknown]; Region: COG1359 196627002573 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 196627002574 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 196627002575 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196627002576 active site 196627002577 motif I; other site 196627002578 motif II; other site 196627002579 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196627002580 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 196627002581 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 196627002582 substrate binding site [chemical binding]; other site 196627002583 oxyanion hole (OAH) forming residues; other site 196627002584 trimer interface [polypeptide binding]; other site 196627002585 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 196627002586 Predicted membrane protein [General function prediction only]; Region: COG4194 196627002587 Predicted esterase [General function prediction only]; Region: COG0627 196627002588 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 196627002589 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 196627002590 MMPL family; Region: MMPL; cl14618 196627002591 The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Region: 2A067; TIGR00921 196627002592 MMPL family; Region: MMPL; cl14618 196627002593 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 196627002594 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4899 196627002595 Domain of unknown function (DUF222); Region: DUF222; pfam02720 196627002596 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 196627002597 active site 196627002598 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 196627002599 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 196627002600 G1 box; other site 196627002601 GTP/Mg2+ binding site [chemical binding]; other site 196627002602 G2 box; other site 196627002603 Switch I region; other site 196627002604 G3 box; other site 196627002605 Switch II region; other site 196627002606 G4 box; other site 196627002607 G5 box; other site 196627002608 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 196627002609 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 196627002610 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 196627002611 putative ligand binding site [chemical binding]; other site 196627002612 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 196627002613 TM-ABC transporter signature motif; other site 196627002614 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 196627002615 TM-ABC transporter signature motif; other site 196627002616 Uncharacterized ABC-type transport system, ATPase component [General function prediction only]; Region: COG4674 196627002617 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 196627002618 Walker A/P-loop; other site 196627002619 ATP binding site [chemical binding]; other site 196627002620 Q-loop/lid; other site 196627002621 ABC transporter signature motif; other site 196627002622 Walker B; other site 196627002623 D-loop; other site 196627002624 H-loop/switch region; other site 196627002625 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 196627002626 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 196627002627 Walker A/P-loop; other site 196627002628 ATP binding site [chemical binding]; other site 196627002629 Q-loop/lid; other site 196627002630 ABC transporter signature motif; other site 196627002631 Walker B; other site 196627002632 D-loop; other site 196627002633 H-loop/switch region; other site 196627002634 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 196627002635 putative active site [active] 196627002636 catalytic residue [active] 196627002637 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 196627002638 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 196627002639 FMN binding site [chemical binding]; other site 196627002640 substrate binding site [chemical binding]; other site 196627002641 putative catalytic residue [active] 196627002642 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 196627002643 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 196627002644 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 196627002645 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 196627002646 putative active site [active] 196627002647 catalytic residue [active] 196627002648 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 196627002649 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 196627002650 5S rRNA interface [nucleotide binding]; other site 196627002651 CTC domain interface [polypeptide binding]; other site 196627002652 L16 interface [polypeptide binding]; other site 196627002653 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693 196627002654 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 196627002655 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 196627002656 active site 196627002657 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 196627002658 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 196627002659 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 196627002660 active site 196627002661 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 196627002662 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 196627002663 Substrate binding site; other site 196627002664 Mg++ binding site; other site 196627002665 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 196627002666 active site 196627002667 substrate binding site [chemical binding]; other site 196627002668 CoA binding site [chemical binding]; other site 196627002669 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196627002670 multicopper oxidase; Provisional; Region: PRK10965 196627002671 The first Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_1_CueO_FtsP; cd04232 196627002672 Domain 2 interface [polypeptide binding]; other site 196627002673 Domain 3 interface [polypeptide binding]; other site 196627002674 trinuclear Cu binding site [ion binding]; other site 196627002675 The second Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_2_CueO_FtsP; cd13867 196627002676 Domain 1 interface [polypeptide binding]; other site 196627002677 Domain 3 interface [polypeptide binding]; other site 196627002678 The third Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_3_CueO_FtsP; cd13890 196627002679 Domain 2 interface [polypeptide binding]; other site 196627002680 Domain 1 interface [polypeptide binding]; other site 196627002681 Type 1 (T1) Cu binding site [ion binding]; other site 196627002682 trinuclear Cu binding site [ion binding]; other site 196627002683 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 196627002684 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 196627002685 Walker A/P-loop; other site 196627002686 ATP binding site [chemical binding]; other site 196627002687 Q-loop/lid; other site 196627002688 ABC transporter signature motif; other site 196627002689 Walker B; other site 196627002690 D-loop; other site 196627002691 H-loop/switch region; other site 196627002692 ABC-2 type transporter; Region: ABC2_membrane; cl17235 196627002693 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 196627002694 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 196627002695 Histidine kinase; Region: HisKA_3; pfam07730 196627002696 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 196627002697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196627002698 active site 196627002699 phosphorylation site [posttranslational modification] 196627002700 intermolecular recognition site; other site 196627002701 dimerization interface [polypeptide binding]; other site 196627002702 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 196627002703 DNA binding residues [nucleotide binding] 196627002704 dimerization interface [polypeptide binding]; other site 196627002705 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 196627002706 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 196627002707 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 196627002708 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196627002709 ABC transporter signature motif; other site 196627002710 Walker B; other site 196627002711 D-loop; other site 196627002712 H-loop/switch region; other site 196627002713 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 196627002714 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 196627002715 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196627002716 Walker A/P-loop; other site 196627002717 ATP binding site [chemical binding]; other site 196627002718 Q-loop/lid; other site 196627002719 ABC transporter signature motif; other site 196627002720 Walker B; other site 196627002721 D-loop; other site 196627002722 H-loop/switch region; other site 196627002723 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 196627002724 UTP:GlnB (protein PII) uridylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: GlnD; COG2844 196627002725 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 196627002726 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 196627002727 Integrase core domain; Region: rve; pfam00665 196627002728 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 196627002729 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 196627002730 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 196627002731 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 196627002732 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196627002733 ATP binding site [chemical binding]; other site 196627002734 putative Mg++ binding site [ion binding]; other site 196627002735 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196627002736 nucleotide binding region [chemical binding]; other site 196627002737 ATP-binding site [chemical binding]; other site 196627002738 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 196627002739 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 196627002740 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 196627002741 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 196627002742 Walker A/P-loop; other site 196627002743 ATP binding site [chemical binding]; other site 196627002744 Q-loop/lid; other site 196627002745 ABC transporter signature motif; other site 196627002746 Walker B; other site 196627002747 D-loop; other site 196627002748 H-loop/switch region; other site 196627002749 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 196627002750 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 196627002751 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196627002752 Walker A/P-loop; other site 196627002753 ATP binding site [chemical binding]; other site 196627002754 Q-loop/lid; other site 196627002755 ABC transporter signature motif; other site 196627002756 Walker B; other site 196627002757 D-loop; other site 196627002758 H-loop/switch region; other site 196627002759 Uncharacterized conserved protein [Function unknown]; Region: COG2898 196627002760 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 196627002761 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 196627002762 Predicted esterase [General function prediction only]; Region: COG0627 196627002763 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 196627002764 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 196627002765 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 196627002766 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 196627002767 homodimer interface [polypeptide binding]; other site 196627002768 metal binding site [ion binding]; metal-binding site 196627002769 Alpha helical Porin B; Region: PorB; pfam11565 196627002770 Alpha helical Porin B; Region: PorB; pfam11565 196627002771 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 196627002772 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 196627002773 N-acetyl-D-glucosamine binding site [chemical binding]; other site 196627002774 enolase; Provisional; Region: eno; PRK00077 196627002775 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 196627002776 dimer interface [polypeptide binding]; other site 196627002777 metal binding site [ion binding]; metal-binding site 196627002778 substrate binding pocket [chemical binding]; other site 196627002779 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 196627002780 Uncharacterized conserved protein [Function unknown]; Region: COG1507 196627002781 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 196627002782 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483 196627002783 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 196627002784 tetramer interface [polypeptide binding]; other site 196627002785 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196627002786 catalytic residue [active] 196627002787 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 196627002788 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 196627002789 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 196627002790 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 196627002791 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 196627002792 Predicted membrane protein [Function unknown]; Region: COG4760 196627002793 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 196627002794 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 196627002795 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 196627002796 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 196627002797 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 196627002798 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196627002799 active site 196627002800 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; cl17260 196627002801 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 196627002802 active site 196627002803 dimer interface [polypeptide binding]; other site 196627002804 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 196627002805 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 196627002806 ATP-binding site [chemical binding]; other site 196627002807 CoA-binding site [chemical binding]; other site 196627002808 Mg2+-binding site [ion binding]; other site 196627002809 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 196627002810 dimer interface [polypeptide binding]; other site 196627002811 active site 196627002812 glycine-pyridoxal phosphate binding site [chemical binding]; other site 196627002813 folate binding site [chemical binding]; other site 196627002814 aminodeoxychorismate synthase, fungal clade; Region: PabB-fungal; TIGR01823 196627002815 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 196627002816 glutamine binding [chemical binding]; other site 196627002817 catalytic triad [active] 196627002818 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 196627002819 chorismate binding enzyme; Region: Chorismate_bind; cl10555 196627002820 substrate-cofactor binding pocket; other site 196627002821 homodimer interface [polypeptide binding]; other site 196627002822 Aminotransferase class IV; Region: Aminotran_4; pfam01063 196627002823 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196627002824 catalytic residue [active] 196627002825 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 196627002826 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 196627002827 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196627002828 Coenzyme A binding pocket [chemical binding]; other site 196627002829 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 196627002830 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 196627002831 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 196627002832 putative active site [active] 196627002833 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 196627002834 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 196627002835 PEA3 subfamily ETS-domain transcription factor N terminal domain; Region: ETS_PEA3_N; pfam04621 196627002836 Transcriptional regulators [Transcription]; Region: FadR; COG2186 196627002837 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 196627002838 DNA-binding site [nucleotide binding]; DNA binding site 196627002839 FCD domain; Region: FCD; pfam07729 196627002840 fumarate hydratase; Reviewed; Region: fumC; PRK00485 196627002841 Class II fumarases; Region: Fumarase_classII; cd01362 196627002842 active site 196627002843 tetramer interface [polypeptide binding]; other site 196627002844 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 196627002845 Predicted flavoprotein [General function prediction only]; Region: COG0431 196627002846 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 196627002847 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 196627002848 active site 196627002849 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 196627002850 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 196627002851 Flavin binding site [chemical binding]; other site 196627002852 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 196627002853 active site 196627002854 dimer interface [polypeptide binding]; other site 196627002855 non-prolyl cis peptide bond; other site 196627002856 insertion regions; other site 196627002857 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 196627002858 putative active site [active] 196627002859 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 196627002860 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 196627002861 metal ion-dependent adhesion site (MIDAS); other site 196627002862 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 196627002863 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 196627002864 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 196627002865 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 196627002866 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 196627002867 generic binding surface II; other site 196627002868 generic binding surface I; other site 196627002869 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 196627002870 Fe-S cluster binding site [ion binding]; other site 196627002871 substrate binding site [chemical binding]; other site 196627002872 catalytic site [active] 196627002873 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 196627002874 Membrane protein of unknown function; Region: DUF360; pfam04020 196627002875 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 196627002876 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 196627002877 Na2 binding site [ion binding]; other site 196627002878 putative substrate binding site 1 [chemical binding]; other site 196627002879 Na binding site 1 [ion binding]; other site 196627002880 putative substrate binding site 2 [chemical binding]; other site 196627002881 Putative esterase; Region: Esterase; pfam00756 196627002882 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 196627002883 GTP-binding protein YchF; Reviewed; Region: PRK09601 196627002884 YchF GTPase; Region: YchF; cd01900 196627002885 G1 box; other site 196627002886 GTP/Mg2+ binding site [chemical binding]; other site 196627002887 Switch I region; other site 196627002888 G2 box; other site 196627002889 Switch II region; other site 196627002890 G3 box; other site 196627002891 G4 box; other site 196627002892 G5 box; other site 196627002893 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 196627002894 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 196627002895 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196627002896 non-specific DNA binding site [nucleotide binding]; other site 196627002897 salt bridge; other site 196627002898 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 196627002899 sequence-specific DNA binding site [nucleotide binding]; other site 196627002900 Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Region: ArgF; COG0078 196627002901 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 196627002902 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 196627002903 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 196627002904 Trehalase; Region: Trehalase; cl17346 196627002905 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 196627002906 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196627002907 active site 196627002908 Transposase; Region: DEDD_Tnp_IS110; pfam01548 196627002909 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 196627002910 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 196627002911 MASE1; Region: MASE1; pfam05231 196627002912 PAS domain S-box; Region: sensory_box; TIGR00229 196627002913 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 196627002914 putative active site [active] 196627002915 heme pocket [chemical binding]; other site 196627002916 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 196627002917 metal binding site [ion binding]; metal-binding site 196627002918 active site 196627002919 I-site; other site 196627002920 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 196627002921 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 196627002922 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 196627002923 DXD motif; other site 196627002924 NNMT/PNMT/TEMT family; Region: NNMT_PNMT_TEMT; pfam01234 196627002925 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 196627002926 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 196627002927 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 196627002928 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 196627002929 active site 196627002930 catalytic tetrad [active] 196627002931 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 196627002932 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 196627002933 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 196627002934 NAD(P) binding site [chemical binding]; other site 196627002935 putative active site [active] 196627002936 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 196627002937 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 196627002938 Sulfate transporter family; Region: Sulfate_transp; pfam00916 196627002939 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 196627002940 AMP-binding domain protein; Validated; Region: PRK08315 196627002941 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 196627002942 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 196627002943 metal ion-dependent adhesion site (MIDAS); other site 196627002944 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 196627002945 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 196627002946 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 196627002947 catalytic core [active] 196627002948 conserved hypothetical protein; Region: TIGR03843 196627002949 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 196627002950 tetramer interface [polypeptide binding]; other site 196627002951 active site 196627002952 Mg2+/Mn2+ binding site [ion binding]; other site 196627002953 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 196627002954 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 196627002955 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196627002956 ABC transporter; Region: ABC_tran_2; pfam12848 196627002957 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 196627002958 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 196627002959 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 196627002960 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 196627002961 PhnA protein; Region: PhnA; pfam03831 196627002962 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 196627002963 putative DNA binding site [nucleotide binding]; other site 196627002964 Transcriptional regulators [Transcription]; Region: MarR; COG1846 196627002965 putative Zn2+ binding site [ion binding]; other site 196627002966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627002967 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196627002968 putative substrate translocation pore; other site 196627002969 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 196627002970 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 196627002971 Transposase; Region: DDE_Tnp_ISL3; pfam01610 196627002972 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 196627002973 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 196627002974 catalytic residue [active] 196627002975 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543 196627002976 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 196627002977 dimerization interface [polypeptide binding]; other site 196627002978 active site 196627002979 quinolinate synthetase; Provisional; Region: PRK09375 196627002980 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 196627002981 nudix motif; other site 196627002982 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 196627002983 Protein of unknown function, DUF606; Region: DUF606; pfam04657 196627002984 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 196627002985 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 196627002986 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 196627002987 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 196627002988 dimer interface [polypeptide binding]; other site 196627002989 benzoate transport; Region: 2A0115; TIGR00895 196627002990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627002991 putative substrate translocation pore; other site 196627002992 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 196627002993 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 196627002994 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 196627002995 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 196627002996 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 196627002997 Walker A/P-loop; other site 196627002998 ATP binding site [chemical binding]; other site 196627002999 Q-loop/lid; other site 196627003000 ABC transporter signature motif; other site 196627003001 Walker B; other site 196627003002 D-loop; other site 196627003003 H-loop/switch region; other site 196627003004 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 196627003005 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 196627003006 Walker A/P-loop; other site 196627003007 ATP binding site [chemical binding]; other site 196627003008 Q-loop/lid; other site 196627003009 ABC transporter signature motif; other site 196627003010 Walker B; other site 196627003011 D-loop; other site 196627003012 H-loop/switch region; other site 196627003013 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 196627003014 hypothetical protein; Provisional; Region: PRK06547 196627003015 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 196627003016 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 196627003017 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 196627003018 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 196627003019 Predicted integral membrane protein [Function unknown]; Region: COG5522 196627003020 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 196627003021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196627003022 Walker A/P-loop; other site 196627003023 ATP binding site [chemical binding]; other site 196627003024 Q-loop/lid; other site 196627003025 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 196627003026 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196627003027 ABC transporter signature motif; other site 196627003028 Walker B; other site 196627003029 D-loop; other site 196627003030 H-loop/switch region; other site 196627003031 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196627003032 Walker A/P-loop; other site 196627003033 ATP binding site [chemical binding]; other site 196627003034 Q-loop/lid; other site 196627003035 ABC transporter signature motif; other site 196627003036 Walker B; other site 196627003037 D-loop; other site 196627003038 H-loop/switch region; other site 196627003039 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 196627003040 dimer interface [polypeptide binding]; other site 196627003041 catalytic triad [active] 196627003042 peroxidatic and resolving cysteines [active] 196627003043 African swine fever virus J13L protein; Region: ASFV_J13L; pfam05568 196627003044 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 196627003045 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 196627003046 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 196627003047 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 196627003048 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424 196627003049 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 196627003050 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 196627003051 Trypsin; Region: Trypsin; pfam00089 196627003052 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 196627003053 active site 196627003054 substrate binding sites [chemical binding]; other site 196627003055 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 196627003056 catalytic residues [active] 196627003057 Uncharacterized membrane protein [Function unknown]; Region: COG3949 196627003058 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 196627003059 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 196627003060 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 196627003061 G1 box; other site 196627003062 putative GEF interaction site [polypeptide binding]; other site 196627003063 GTP/Mg2+ binding site [chemical binding]; other site 196627003064 Switch I region; other site 196627003065 G2 box; other site 196627003066 G3 box; other site 196627003067 Switch II region; other site 196627003068 G4 box; other site 196627003069 G5 box; other site 196627003070 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 196627003071 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 196627003072 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 196627003073 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 196627003074 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 196627003075 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 196627003076 Ferredoxin [Energy production and conversion]; Region: COG1146 196627003077 4Fe-4S binding domain; Region: Fer4; pfam00037 196627003078 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 196627003079 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 196627003080 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196627003081 homodimer interface [polypeptide binding]; other site 196627003082 catalytic residue [active] 196627003083 GtrA-like protein; Region: GtrA; pfam04138 196627003084 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 196627003085 active site 196627003086 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 196627003087 Tetrahydrodipicolinate N-succinyltransferase N-terminal; Region: THDPS_N; pfam14790 196627003088 Tetrahydrodipicolinate N-succinyltransferase middle; Region: THDPS_M; pfam14789 196627003089 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 196627003090 putative trimer interface [polypeptide binding]; other site 196627003091 putative CoA binding site [chemical binding]; other site 196627003092 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 196627003093 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 196627003094 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 196627003095 Tetrahydrodipicolinate N-succinyltransferase middle; Region: THDPS_M; pfam14789 196627003096 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 196627003097 putative trimer interface [polypeptide binding]; other site 196627003098 putative CoA binding site [chemical binding]; other site 196627003099 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 196627003100 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 196627003101 metal binding site [ion binding]; metal-binding site 196627003102 putative dimer interface [polypeptide binding]; other site 196627003103 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 196627003104 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 196627003105 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 196627003106 substrate binding pocket [chemical binding]; other site 196627003107 dimer interface [polypeptide binding]; other site 196627003108 inhibitor binding site; inhibition site 196627003109 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 196627003110 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 196627003111 Ligand binding site; other site 196627003112 Putative Catalytic site; other site 196627003113 DXD motif; other site 196627003114 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 196627003115 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196627003116 S-adenosylmethionine binding site [chemical binding]; other site 196627003117 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 196627003118 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 196627003119 active site 196627003120 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 196627003121 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 196627003122 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 196627003123 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 196627003124 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 196627003125 ligand binding site; other site 196627003126 oligomer interface; other site 196627003127 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 196627003128 dimer interface [polypeptide binding]; other site 196627003129 N-terminal domain interface [polypeptide binding]; other site 196627003130 sulfate 1 binding site; other site 196627003131 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 196627003132 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 196627003133 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 196627003134 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 196627003135 DNA binding residues [nucleotide binding] 196627003136 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 196627003137 sec-independent translocase; Provisional; Region: tatB; PRK00182 196627003138 Domain of unknown function DUF59; Region: DUF59; pfam01883 196627003139 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 196627003140 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 196627003141 Walker A motif; other site 196627003142 Predicted membrane protein [Function unknown]; Region: COG4420 196627003143 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 196627003144 MgtE intracellular N domain; Region: MgtE_N; smart00924 196627003145 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 196627003146 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 196627003147 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 196627003148 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 196627003149 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 196627003150 TPP-binding site [chemical binding]; other site 196627003151 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 196627003152 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 196627003153 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 196627003154 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196627003155 Walker A/P-loop; other site 196627003156 ATP binding site [chemical binding]; other site 196627003157 Q-loop/lid; other site 196627003158 ABC transporter signature motif; other site 196627003159 Walker B; other site 196627003160 D-loop; other site 196627003161 H-loop/switch region; other site 196627003162 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 196627003163 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 196627003164 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196627003165 Walker A/P-loop; other site 196627003166 ATP binding site [chemical binding]; other site 196627003167 Q-loop/lid; other site 196627003168 ABC transporter signature motif; other site 196627003169 Walker B; other site 196627003170 D-loop; other site 196627003171 H-loop/switch region; other site 196627003172 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 196627003173 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 196627003174 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 196627003175 shikimate binding site; other site 196627003176 NAD(P) binding site [chemical binding]; other site 196627003177 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 196627003178 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 196627003179 substrate binding pocket [chemical binding]; other site 196627003180 catalytic triad [active] 196627003181 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 196627003182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627003183 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196627003184 putative substrate translocation pore; other site 196627003185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627003186 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196627003187 putative substrate translocation pore; other site 196627003188 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 196627003189 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 196627003190 THF binding site; other site 196627003191 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 196627003192 substrate binding site [chemical binding]; other site 196627003193 THF binding site; other site 196627003194 zinc-binding site [ion binding]; other site 196627003195 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 196627003196 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 196627003197 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 196627003198 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 196627003199 active site 196627003200 nucleophile elbow; other site 196627003201 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 196627003202 Condensation domain; Region: Condensation; cl19241 196627003203 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 196627003204 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 196627003205 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 196627003206 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196627003207 Q-loop/lid; other site 196627003208 ABC transporter signature motif; other site 196627003209 Walker B; other site 196627003210 D-loop; other site 196627003211 H-loop/switch region; other site 196627003212 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 196627003213 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 196627003214 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196627003215 Walker A/P-loop; other site 196627003216 ATP binding site [chemical binding]; other site 196627003217 Q-loop/lid; other site 196627003218 ABC transporter signature motif; other site 196627003219 Walker B; other site 196627003220 D-loop; other site 196627003221 H-loop/switch region; other site 196627003222 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 196627003223 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 196627003224 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 196627003225 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 196627003226 PLD-like domain; Region: PLDc_2; pfam13091 196627003227 putative homodimer interface [polypeptide binding]; other site 196627003228 putative active site [active] 196627003229 catalytic site [active] 196627003230 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 196627003231 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196627003232 ATP binding site [chemical binding]; other site 196627003233 putative Mg++ binding site [ion binding]; other site 196627003234 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196627003235 nucleotide binding region [chemical binding]; other site 196627003236 ATP-binding site [chemical binding]; other site 196627003237 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 196627003238 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 196627003239 active site 196627003240 8-oxo-dGMP binding site [chemical binding]; other site 196627003241 nudix motif; other site 196627003242 metal binding site [ion binding]; metal-binding site 196627003243 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 196627003244 Spore germination protein; Region: Spore_permease; cl17796 196627003245 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 196627003246 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 196627003247 ATP binding site [chemical binding]; other site 196627003248 Mg++ binding site [ion binding]; other site 196627003249 motif III; other site 196627003250 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196627003251 nucleotide binding region [chemical binding]; other site 196627003252 ATP-binding site [chemical binding]; other site 196627003253 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 196627003254 putative RNA binding site [nucleotide binding]; other site 196627003255 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 196627003256 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 196627003257 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 196627003258 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 196627003259 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 196627003260 active site 196627003261 dimer interface [polypeptide binding]; other site 196627003262 metal binding site [ion binding]; metal-binding site 196627003263 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 196627003264 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 196627003265 active site 196627003266 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 196627003267 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 196627003268 Na binding site [ion binding]; other site 196627003269 SNF2 Helicase protein; Region: DUF3670; pfam12419 196627003270 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 196627003271 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196627003272 ATP binding site [chemical binding]; other site 196627003273 putative Mg++ binding site [ion binding]; other site 196627003274 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196627003275 nucleotide binding region [chemical binding]; other site 196627003276 ATP-binding site [chemical binding]; other site 196627003277 Uncharacterized conserved protein [Function unknown]; Region: COG4279 196627003278 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 196627003279 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 196627003280 active site 196627003281 metal binding site [ion binding]; metal-binding site 196627003282 DNA binding site [nucleotide binding] 196627003283 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 196627003284 AAA domain; Region: AAA_23; pfam13476 196627003285 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 196627003286 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 196627003287 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 196627003288 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 196627003289 Uncharacterized conserved protein [Function unknown]; Region: COG2353 196627003290 Transcriptional regulators [Transcription]; Region: MarR; COG1846 196627003291 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 196627003292 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 196627003293 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 196627003294 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 196627003295 ligand binding site [chemical binding]; other site 196627003296 flexible hinge region; other site 196627003297 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 196627003298 non-specific DNA interactions [nucleotide binding]; other site 196627003299 DNA binding site [nucleotide binding] 196627003300 sequence specific DNA binding site [nucleotide binding]; other site 196627003301 putative cAMP binding site [chemical binding]; other site 196627003302 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 196627003303 metal-binding site [ion binding] 196627003304 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 196627003305 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 196627003306 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196627003307 motif II; other site 196627003308 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 196627003309 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 196627003310 synthetase active site [active] 196627003311 NTP binding site [chemical binding]; other site 196627003312 metal binding site [ion binding]; metal-binding site 196627003313 Putative lysophospholipase; Region: Hydrolase_4; cl19140 196627003314 TAP-like protein; Region: Abhydrolase_4; pfam08386 196627003315 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 196627003316 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 196627003317 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 196627003318 active site 196627003319 HIGH motif; other site 196627003320 KMSK motif region; other site 196627003321 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 196627003322 tRNA binding surface [nucleotide binding]; other site 196627003323 anticodon binding site; other site 196627003324 diaminopimelate decarboxylase; Region: lysA; TIGR01048 196627003325 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 196627003326 active site 196627003327 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 196627003328 substrate binding site [chemical binding]; other site 196627003329 catalytic residues [active] 196627003330 dimer interface [polypeptide binding]; other site 196627003331 homoserine dehydrogenase; Provisional; Region: PRK06349 196627003332 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 196627003333 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 196627003334 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 196627003335 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 196627003336 Predicted transcriptional regulator [Transcription]; Region: COG2345 196627003337 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 196627003338 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 196627003339 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 196627003340 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 196627003341 Respiratory nitrate reductase beta C-terminal; Region: Nitr_red_bet_C; pfam14711 196627003342 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 196627003343 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 196627003344 molybdopterin cofactor binding site; other site 196627003345 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 196627003346 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 196627003347 molybdopterin cofactor binding site; other site 196627003348 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 196627003349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627003350 putative substrate translocation pore; other site 196627003351 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 196627003352 MPT binding site; other site 196627003353 trimer interface [polypeptide binding]; other site 196627003354 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 196627003355 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 196627003356 active site 196627003357 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 196627003358 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 196627003359 Domain of unknown function DUF21; Region: DUF21; pfam01595 196627003360 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 196627003361 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 196627003362 Domain of unknown function DUF21; Region: DUF21; pfam01595 196627003363 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 196627003364 Transporter associated domain; Region: CorC_HlyC; pfam03471 196627003365 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 196627003366 GTP binding site; other site 196627003367 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 196627003368 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 196627003369 dimer interface [polypeptide binding]; other site 196627003370 putative functional site; other site 196627003371 putative MPT binding site; other site 196627003372 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 196627003373 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 196627003374 FeS/SAM binding site; other site 196627003375 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 196627003376 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620 196627003377 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 196627003378 dimer interface [polypeptide binding]; other site 196627003379 acyl-activating enzyme (AAE) consensus motif; other site 196627003380 putative active site [active] 196627003381 AMP binding site [chemical binding]; other site 196627003382 putative CoA binding site [chemical binding]; other site 196627003383 transcription termination factor Rho; Provisional; Region: PRK12678 196627003384 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 196627003385 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 196627003386 RNA binding site [nucleotide binding]; other site 196627003387 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 196627003388 multimer interface [polypeptide binding]; other site 196627003389 Walker A motif; other site 196627003390 ATP binding site [chemical binding]; other site 196627003391 Walker B motif; other site 196627003392 peptide chain release factor 1; Validated; Region: prfA; PRK00591 196627003393 This domain is found in peptide chain release factors; Region: PCRF; smart00937 196627003394 RF-1 domain; Region: RF-1; pfam00472 196627003395 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 196627003396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196627003397 S-adenosylmethionine binding site [chemical binding]; other site 196627003398 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 196627003399 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 196627003400 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 196627003401 Mg++ binding site [ion binding]; other site 196627003402 putative catalytic motif [active] 196627003403 substrate binding site [chemical binding]; other site 196627003404 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 196627003405 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 196627003406 F0F1 ATP synthase subunit C; Validated; Region: PRK07874 196627003407 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 196627003408 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 196627003409 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 196627003410 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 196627003411 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 196627003412 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 196627003413 beta subunit interaction interface [polypeptide binding]; other site 196627003414 Walker A motif; other site 196627003415 ATP binding site [chemical binding]; other site 196627003416 Walker B motif; other site 196627003417 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 196627003418 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 196627003419 core domain interface [polypeptide binding]; other site 196627003420 delta subunit interface [polypeptide binding]; other site 196627003421 epsilon subunit interface [polypeptide binding]; other site 196627003422 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 196627003423 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 196627003424 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 196627003425 alpha subunit interaction interface [polypeptide binding]; other site 196627003426 Walker A motif; other site 196627003427 ATP binding site [chemical binding]; other site 196627003428 Walker B motif; other site 196627003429 inhibitor binding site; inhibition site 196627003430 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 196627003431 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 196627003432 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 196627003433 gamma subunit interface [polypeptide binding]; other site 196627003434 epsilon subunit interface [polypeptide binding]; other site 196627003435 LBP interface [polypeptide binding]; other site 196627003436 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 196627003437 hypothetical protein; Provisional; Region: PRK03298 196627003438 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 196627003439 dimer interface [polypeptide binding]; other site 196627003440 substrate binding site [chemical binding]; other site 196627003441 metal binding site [ion binding]; metal-binding site 196627003442 Uncharacterized conserved protein [Function unknown]; Region: COG0011 196627003443 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 196627003444 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 196627003445 Tetratricopeptide repeat; Region: TPR_20; pfam14561 196627003446 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 196627003447 active site 196627003448 dimer interface [polypeptide binding]; other site 196627003449 non-prolyl cis peptide bond; other site 196627003450 insertion regions; other site 196627003451 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 196627003452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196627003453 dimer interface [polypeptide binding]; other site 196627003454 conserved gate region; other site 196627003455 putative PBP binding loops; other site 196627003456 ABC-ATPase subunit interface; other site 196627003457 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 196627003458 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196627003459 Walker A/P-loop; other site 196627003460 ATP binding site [chemical binding]; other site 196627003461 Q-loop/lid; other site 196627003462 ABC transporter signature motif; other site 196627003463 Walker B; other site 196627003464 D-loop; other site 196627003465 H-loop/switch region; other site 196627003466 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 196627003467 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 196627003468 substrate binding pocket [chemical binding]; other site 196627003469 membrane-bound complex binding site; other site 196627003470 hinge residues; other site 196627003471 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 196627003472 glycogen branching enzyme; Provisional; Region: PRK05402 196627003473 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 196627003474 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 196627003475 active site 196627003476 catalytic site [active] 196627003477 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 196627003478 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 196627003479 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 196627003480 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 196627003481 active site 196627003482 homodimer interface [polypeptide binding]; other site 196627003483 catalytic site [active] 196627003484 acceptor binding site [chemical binding]; other site 196627003485 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 196627003486 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196627003487 Walker A/P-loop; other site 196627003488 ATP binding site [chemical binding]; other site 196627003489 Q-loop/lid; other site 196627003490 ABC transporter signature motif; other site 196627003491 Walker B; other site 196627003492 D-loop; other site 196627003493 H-loop/switch region; other site 196627003494 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 196627003495 Ligand binding site [chemical binding]; other site 196627003496 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 196627003497 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 196627003498 Ligand Binding Site [chemical binding]; other site 196627003499 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 196627003500 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 196627003501 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 196627003502 catalytic residue [active] 196627003503 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 196627003504 HipA N-terminal domain; Region: Couple_hipA; cl11853 196627003505 HipA-like N-terminal domain; Region: HipA_N; pfam07805 196627003506 HipA-like C-terminal domain; Region: HipA_C; pfam07804 196627003507 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196627003508 salt bridge; other site 196627003509 non-specific DNA binding site [nucleotide binding]; other site 196627003510 sequence-specific DNA binding site [nucleotide binding]; other site 196627003511 putative acetyltransferase; Provisional; Region: PRK03624 196627003512 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196627003513 Coenzyme A binding pocket [chemical binding]; other site 196627003514 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196627003515 S-adenosylmethionine binding site [chemical binding]; other site 196627003516 AAA ATPase domain; Region: AAA_16; pfam13191 196627003517 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 196627003518 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 196627003519 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 196627003520 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 196627003521 Ligand Binding Site [chemical binding]; other site 196627003522 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 196627003523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627003524 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196627003525 putative substrate translocation pore; other site 196627003526 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 196627003527 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 196627003528 active site 196627003529 catalytic site [active] 196627003530 substrate binding site [chemical binding]; other site 196627003531 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 196627003532 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 196627003533 nucleotide binding pocket [chemical binding]; other site 196627003534 K-X-D-G motif; other site 196627003535 catalytic site [active] 196627003536 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 196627003537 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 196627003538 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 196627003539 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 196627003540 Dimer interface [polypeptide binding]; other site 196627003541 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 196627003542 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 196627003543 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 196627003544 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 196627003545 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 196627003546 FAD binding pocket [chemical binding]; other site 196627003547 FAD binding motif [chemical binding]; other site 196627003548 phosphate binding motif [ion binding]; other site 196627003549 NAD binding pocket [chemical binding]; other site 196627003550 phosphofructokinase; Region: PFK_mixed; TIGR02483 196627003551 active site 196627003552 ADP/pyrophosphate binding site [chemical binding]; other site 196627003553 dimerization interface [polypeptide binding]; other site 196627003554 allosteric effector site; other site 196627003555 fructose-1,6-bisphosphate binding site; other site 196627003556 Transcriptional regulators [Transcription]; Region: PurR; COG1609 196627003557 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 196627003558 DNA binding site [nucleotide binding] 196627003559 domain linker motif; other site 196627003560 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 196627003561 dimerization interface [polypeptide binding]; other site 196627003562 putative ligand binding site [chemical binding]; other site 196627003563 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 196627003564 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 196627003565 Walker A/P-loop; other site 196627003566 ATP binding site [chemical binding]; other site 196627003567 Q-loop/lid; other site 196627003568 ABC transporter signature motif; other site 196627003569 Walker B; other site 196627003570 D-loop; other site 196627003571 H-loop/switch region; other site 196627003572 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 196627003573 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 196627003574 TM-ABC transporter signature motif; other site 196627003575 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 196627003576 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 196627003577 ligand binding site [chemical binding]; other site 196627003578 dimerization interface [polypeptide binding]; other site 196627003579 D-ribose pyranase; Provisional; Region: PRK11797 196627003580 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 196627003581 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 196627003582 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 196627003583 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 196627003584 siderophore binding site; other site 196627003585 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 196627003586 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 196627003587 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 196627003588 GatB domain; Region: GatB_Yqey; smart00845 196627003589 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 196627003590 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 196627003591 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 196627003592 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 196627003593 active site 196627003594 catalytic tetrad [active] 196627003595 L-lysine exporter; Region: 2a75; TIGR00948 196627003596 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 196627003597 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 196627003598 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 196627003599 dimerization interface [polypeptide binding]; other site 196627003600 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 196627003601 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 196627003602 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 196627003603 putative dimer interface [polypeptide binding]; other site 196627003604 N-terminal domain interface [polypeptide binding]; other site 196627003605 putative substrate binding pocket (H-site) [chemical binding]; other site 196627003606 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 196627003607 Predicted membrane protein [Function unknown]; Region: COG2259 196627003608 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 196627003609 Bacterial PH domain; Region: bPH_6; pfam10756 196627003610 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 196627003611 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 196627003612 Mechanosensitive ion channel; Region: MS_channel; pfam00924 196627003613 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 196627003614 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 196627003615 PYR/PP interface [polypeptide binding]; other site 196627003616 dimer interface [polypeptide binding]; other site 196627003617 TPP binding site [chemical binding]; other site 196627003618 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 196627003619 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 196627003620 TPP-binding site [chemical binding]; other site 196627003621 dimer interface [polypeptide binding]; other site 196627003622 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 196627003623 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 196627003624 putative valine binding site [chemical binding]; other site 196627003625 dimer interface [polypeptide binding]; other site 196627003626 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 196627003627 ketol-acid reductoisomerase; Provisional; Region: PRK05479 196627003628 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 196627003629 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 196627003630 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 196627003631 NMT1-like family; Region: NMT1_2; pfam13379 196627003632 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 196627003633 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 196627003634 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 196627003635 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 196627003636 Uncharacterized conserved protein [Function unknown]; Region: COG1479 196627003637 Uncharacterized conserved protein [Function unknown]; Region: COG3472 196627003638 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 196627003639 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 196627003640 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 196627003641 ligand binding site [chemical binding]; other site 196627003642 NAD binding site [chemical binding]; other site 196627003643 dimerization interface [polypeptide binding]; other site 196627003644 catalytic site [active] 196627003645 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 196627003646 putative L-serine binding site [chemical binding]; other site 196627003647 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 196627003648 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 196627003649 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 196627003650 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 196627003651 substrate binding pocket [chemical binding]; other site 196627003652 membrane-bound complex binding site; other site 196627003653 hinge residues; other site 196627003654 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 196627003655 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 196627003656 ligand binding site [chemical binding]; other site 196627003657 flexible hinge region; other site 196627003658 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 196627003659 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 196627003660 metal binding triad; other site 196627003661 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 196627003662 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 196627003663 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 196627003664 active site 196627003665 catalytic site [active] 196627003666 substrate binding site [chemical binding]; other site 196627003667 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 196627003668 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 196627003669 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 196627003670 Methyltransferase domain; Region: Methyltransf_31; pfam13847 196627003671 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196627003672 S-adenosylmethionine binding site [chemical binding]; other site 196627003673 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 196627003674 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 196627003675 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 196627003676 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 196627003677 active site 196627003678 HIGH motif; other site 196627003679 KMSKS motif; other site 196627003680 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196627003681 salt bridge; other site 196627003682 non-specific DNA binding site [nucleotide binding]; other site 196627003683 sequence-specific DNA binding site [nucleotide binding]; other site 196627003684 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 196627003685 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 196627003686 putative hydrophobic ligand binding site [chemical binding]; other site 196627003687 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 196627003688 WHG domain; Region: WHG; pfam13305 196627003689 hydrophobic ligand binding site; other site 196627003690 Uncharacterized conserved protein [Function unknown]; Region: COG4891 196627003691 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 196627003692 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 196627003693 ThiC-associated domain; Region: ThiC-associated; pfam13667 196627003694 ThiC family; Region: ThiC; pfam01964 196627003695 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 196627003696 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 196627003697 homodimer interface [polypeptide binding]; other site 196627003698 active site pocket [active] 196627003699 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 196627003700 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 196627003701 active site residue [active] 196627003702 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 196627003703 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 196627003704 HD domain; Region: HD_4; pfam13328 196627003705 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 196627003706 Transcriptional regulator [Transcription]; Region: IclR; COG1414 196627003707 Bacterial transcriptional regulator; Region: IclR; pfam01614 196627003708 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 196627003709 substrate binding site [chemical binding]; other site 196627003710 ligand binding site [chemical binding]; other site 196627003711 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 196627003712 substrate binding site [chemical binding]; other site 196627003713 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 196627003714 active site 196627003715 Ap6A binding site [chemical binding]; other site 196627003716 nudix motif; other site 196627003717 metal binding site [ion binding]; metal-binding site 196627003718 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 196627003719 catalytic core [active] 196627003720 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 196627003721 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 196627003722 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 196627003723 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 196627003724 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 196627003725 ATP-grasp domain; Region: ATP-grasp_4; cl17255 196627003726 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 196627003727 thiamine monophosphate kinase; Provisional; Region: PRK05731 196627003728 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 196627003729 ATP binding site [chemical binding]; other site 196627003730 dimerization interface [polypeptide binding]; other site 196627003731 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 196627003732 ligand binding site [chemical binding]; other site 196627003733 active site 196627003734 UGI interface [polypeptide binding]; other site 196627003735 catalytic site [active] 196627003736 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 196627003737 DAK2 domain; Region: Dak2; pfam02734 196627003738 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 196627003739 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 196627003740 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 196627003741 generic binding surface II; other site 196627003742 ssDNA binding site; other site 196627003743 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196627003744 ATP binding site [chemical binding]; other site 196627003745 putative Mg++ binding site [ion binding]; other site 196627003746 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196627003747 nucleotide binding region [chemical binding]; other site 196627003748 ATP-binding site [chemical binding]; other site 196627003749 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 196627003750 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 196627003751 carboxyltransferase (CT) interaction site; other site 196627003752 biotinylation site [posttranslational modification]; other site 196627003753 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196627003754 S-adenosylmethionine binding site [chemical binding]; other site 196627003755 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 196627003756 active site 196627003757 (T/H)XGH motif; other site 196627003758 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 196627003759 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 196627003760 Walker A/P-loop; other site 196627003761 ATP binding site [chemical binding]; other site 196627003762 Q-loop/lid; other site 196627003763 ABC transporter signature motif; other site 196627003764 Walker B; other site 196627003765 D-loop; other site 196627003766 H-loop/switch region; other site 196627003767 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 196627003768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196627003769 dimer interface [polypeptide binding]; other site 196627003770 conserved gate region; other site 196627003771 putative PBP binding loops; other site 196627003772 ABC-ATPase subunit interface; other site 196627003773 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 196627003774 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 196627003775 substrate binding pocket [chemical binding]; other site 196627003776 membrane-bound complex binding site; other site 196627003777 hinge residues; other site 196627003778 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 196627003779 Domain of unknown function (DUF368); Region: DUF368; pfam04018 196627003780 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 196627003781 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 196627003782 active site 196627003783 DNA binding site [nucleotide binding] 196627003784 Int/Topo IB signature motif; other site 196627003785 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 196627003786 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4815 196627003787 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 196627003788 Uncharacterized conserved small protein [Function unknown]; Region: COG5428 196627003789 Integrase core domain; Region: rve_3; cl15866 196627003790 putative assembly protein; Provisional; Region: PRK10833 196627003791 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 196627003792 Mitotic checkpoint regulator, MAD2B-interacting; Region: PRCC; pfam10253 196627003793 DNA polymerase I; Provisional; Region: PRK05755 196627003794 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 196627003795 active site 196627003796 metal binding site 1 [ion binding]; metal-binding site 196627003797 putative 5' ssDNA interaction site; other site 196627003798 metal binding site 3; metal-binding site 196627003799 metal binding site 2 [ion binding]; metal-binding site 196627003800 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 196627003801 putative DNA binding site [nucleotide binding]; other site 196627003802 putative metal binding site [ion binding]; other site 196627003803 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 196627003804 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 196627003805 active site 196627003806 DNA binding site [nucleotide binding] 196627003807 catalytic site [active] 196627003808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627003809 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196627003810 putative substrate translocation pore; other site 196627003811 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196627003812 salt bridge; other site 196627003813 non-specific DNA binding site [nucleotide binding]; other site 196627003814 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 196627003815 sequence-specific DNA binding site [nucleotide binding]; other site 196627003816 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 196627003817 active site 196627003818 catalytic tetrad [active] 196627003819 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 196627003820 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196627003821 S-adenosylmethionine binding site [chemical binding]; other site 196627003822 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 196627003823 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 196627003824 RNA binding site [nucleotide binding]; other site 196627003825 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 196627003826 RNA binding site [nucleotide binding]; other site 196627003827 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 196627003828 RNA binding site [nucleotide binding]; other site 196627003829 S1 RNA binding domain; Region: S1; pfam00575 196627003830 RNA binding site [nucleotide binding]; other site 196627003831 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 196627003832 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 196627003833 active site turn [active] 196627003834 phosphorylation site [posttranslational modification] 196627003835 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 196627003836 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 196627003837 HPr interaction site; other site 196627003838 glycerol kinase (GK) interaction site [polypeptide binding]; other site 196627003839 active site 196627003840 phosphorylation site [posttranslational modification] 196627003841 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 196627003842 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 196627003843 CoA-binding site [chemical binding]; other site 196627003844 ATP-binding [chemical binding]; other site 196627003845 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 196627003846 active site 196627003847 tetramer interface [polypeptide binding]; other site 196627003848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627003849 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196627003850 putative substrate translocation pore; other site 196627003851 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 196627003852 substrate binding site [chemical binding]; other site 196627003853 dimer interface [polypeptide binding]; other site 196627003854 ATP binding site [chemical binding]; other site 196627003855 Transcriptional regulators [Transcription]; Region: PurR; COG1609 196627003856 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 196627003857 DNA binding site [nucleotide binding] 196627003858 domain linker motif; other site 196627003859 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 196627003860 dimerization interface [polypeptide binding]; other site 196627003861 putative ligand binding site [chemical binding]; other site 196627003862 excinuclease ABC subunit B; Provisional; Region: PRK05298 196627003863 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196627003864 ATP binding site [chemical binding]; other site 196627003865 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196627003866 nucleotide binding region [chemical binding]; other site 196627003867 ATP-binding site [chemical binding]; other site 196627003868 Ultra-violet resistance protein B; Region: UvrB; pfam12344 196627003869 UvrB/uvrC motif; Region: UVR; pfam02151 196627003870 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 196627003871 Ligand Binding Site [chemical binding]; other site 196627003872 Predicted transcriptional regulators [Transcription]; Region: COG1733 196627003873 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 196627003874 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 196627003875 NADP binding site [chemical binding]; other site 196627003876 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 196627003877 Part of AAA domain; Region: AAA_19; pfam13245 196627003878 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 196627003879 Predicted membrane protein [Function unknown]; Region: COG2259 196627003880 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 196627003881 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 196627003882 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 196627003883 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 196627003884 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 196627003885 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 196627003886 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 196627003887 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 196627003888 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 196627003889 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 196627003890 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 196627003891 23S rRNA binding site [nucleotide binding]; other site 196627003892 L21 binding site [polypeptide binding]; other site 196627003893 L13 binding site [polypeptide binding]; other site 196627003894 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446 196627003895 GIY-YIG motif/motif A; other site 196627003896 putative active site [active] 196627003897 putative metal binding site [ion binding]; other site 196627003898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196627003899 dimer interface [polypeptide binding]; other site 196627003900 conserved gate region; other site 196627003901 putative PBP binding loops; other site 196627003902 ABC-ATPase subunit interface; other site 196627003903 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 196627003904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196627003905 dimer interface [polypeptide binding]; other site 196627003906 conserved gate region; other site 196627003907 putative PBP binding loops; other site 196627003908 ABC-ATPase subunit interface; other site 196627003909 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 196627003910 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 196627003911 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 196627003912 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 196627003913 Walker A/P-loop; other site 196627003914 ATP binding site [chemical binding]; other site 196627003915 Q-loop/lid; other site 196627003916 ABC transporter signature motif; other site 196627003917 Walker B; other site 196627003918 D-loop; other site 196627003919 H-loop/switch region; other site 196627003920 TOBE domain; Region: TOBE_2; pfam08402 196627003921 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 196627003922 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 196627003923 active site 196627003924 catalytic site [active] 196627003925 metal binding site [ion binding]; metal-binding site 196627003926 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 196627003927 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 196627003928 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 196627003929 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 196627003930 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 196627003931 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 196627003932 dimer interface [polypeptide binding]; other site 196627003933 motif 1; other site 196627003934 active site 196627003935 motif 2; other site 196627003936 motif 3; other site 196627003937 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 196627003938 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 196627003939 putative tRNA-binding site [nucleotide binding]; other site 196627003940 B3/4 domain; Region: B3_4; pfam03483 196627003941 tRNA synthetase B5 domain; Region: B5; smart00874 196627003942 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 196627003943 dimer interface [polypeptide binding]; other site 196627003944 motif 1; other site 196627003945 motif 3; other site 196627003946 motif 2; other site 196627003947 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 196627003948 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 196627003949 active site 196627003950 catalytic triad [active] 196627003951 oxyanion hole [active] 196627003952 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 196627003953 ribonuclease E; Reviewed; Region: rne; PRK10811 196627003954 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 196627003955 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 196627003956 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 196627003957 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 196627003958 heterotetramer interface [polypeptide binding]; other site 196627003959 active site pocket [active] 196627003960 cleavage site 196627003961 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 196627003962 feedback inhibition sensing region; other site 196627003963 homohexameric interface [polypeptide binding]; other site 196627003964 nucleotide binding site [chemical binding]; other site 196627003965 N-acetyl-L-glutamate binding site [chemical binding]; other site 196627003966 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 196627003967 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 196627003968 inhibitor-cofactor binding pocket; inhibition site 196627003969 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196627003970 catalytic residue [active] 196627003971 ornithine carbamoyltransferase; Provisional; Region: PRK00779 196627003972 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 196627003973 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 196627003974 arginine repressor; Provisional; Region: PRK03341 196627003975 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 196627003976 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 196627003977 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 196627003978 ANP binding site [chemical binding]; other site 196627003979 Substrate Binding Site II [chemical binding]; other site 196627003980 Substrate Binding Site I [chemical binding]; other site 196627003981 argininosuccinate lyase; Provisional; Region: PRK00855 196627003982 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 196627003983 active sites [active] 196627003984 tetramer interface [polypeptide binding]; other site 196627003985 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 196627003986 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 196627003987 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 196627003988 metal ion-dependent adhesion site (MIDAS); other site 196627003989 Uncharacterized conserved protein [Function unknown]; Region: COG2835 196627003990 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 196627003991 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 196627003992 active site 196627003993 HIGH motif; other site 196627003994 dimer interface [polypeptide binding]; other site 196627003995 KMSKS motif; other site 196627003996 S4 domain; Region: S4_2; cl17325 196627003997 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 196627003998 RNA binding surface [nucleotide binding]; other site 196627003999 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 196627004000 Ligand Binding Site [chemical binding]; other site 196627004001 transcription termination factor Rho; Provisional; Region: PRK12678 196627004002 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 196627004003 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 196627004004 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196627004005 active site 196627004006 motif I; other site 196627004007 motif II; other site 196627004008 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196627004009 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 196627004010 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 196627004011 RNA binding surface [nucleotide binding]; other site 196627004012 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196627004013 S-adenosylmethionine binding site [chemical binding]; other site 196627004014 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 196627004015 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 196627004016 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 196627004017 Walker A/P-loop; other site 196627004018 ATP binding site [chemical binding]; other site 196627004019 Q-loop/lid; other site 196627004020 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 196627004021 ABC transporter signature motif; other site 196627004022 Walker B; other site 196627004023 D-loop; other site 196627004024 H-loop/switch region; other site 196627004025 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 196627004026 Thiamine pyrophosphokinase; Region: TPK; cd07995 196627004027 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 196627004028 CTP synthetase; Validated; Region: pyrG; PRK05380 196627004029 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 196627004030 Catalytic site [active] 196627004031 active site 196627004032 UTP binding site [chemical binding]; other site 196627004033 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 196627004034 active site 196627004035 putative oxyanion hole; other site 196627004036 catalytic triad [active] 196627004037 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 196627004038 dimer interface [polypeptide binding]; other site 196627004039 ADP-ribose binding site [chemical binding]; other site 196627004040 active site 196627004041 nudix motif; other site 196627004042 metal binding site [ion binding]; metal-binding site 196627004043 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 196627004044 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 196627004045 active site 196627004046 Int/Topo IB signature motif; other site 196627004047 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 196627004048 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 196627004049 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196627004050 Walker A/P-loop; other site 196627004051 ATP binding site [chemical binding]; other site 196627004052 Q-loop/lid; other site 196627004053 ABC transporter signature motif; other site 196627004054 Walker B; other site 196627004055 D-loop; other site 196627004056 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 196627004057 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 196627004058 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 196627004059 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 196627004060 P-loop; other site 196627004061 Magnesium ion binding site [ion binding]; other site 196627004062 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 196627004063 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 196627004064 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 196627004065 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 196627004066 active site residue [active] 196627004067 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 196627004068 active site residue [active] 196627004069 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 196627004070 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 196627004071 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 196627004072 RNA binding surface [nucleotide binding]; other site 196627004073 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 196627004074 active site 196627004075 cytidylate kinase; Provisional; Region: cmk; PRK00023 196627004076 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 196627004077 CMP-binding site; other site 196627004078 The sites determining sugar specificity; other site 196627004079 GTP-binding protein Der; Reviewed; Region: PRK03003 196627004080 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 196627004081 G1 box; other site 196627004082 GTP/Mg2+ binding site [chemical binding]; other site 196627004083 Switch I region; other site 196627004084 G2 box; other site 196627004085 Switch II region; other site 196627004086 G3 box; other site 196627004087 G4 box; other site 196627004088 G5 box; other site 196627004089 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 196627004090 G1 box; other site 196627004091 GTP/Mg2+ binding site [chemical binding]; other site 196627004092 Switch I region; other site 196627004093 G2 box; other site 196627004094 G3 box; other site 196627004095 Switch II region; other site 196627004096 G4 box; other site 196627004097 G5 box; other site 196627004098 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 196627004099 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 196627004100 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 196627004101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196627004102 S-adenosylmethionine binding site [chemical binding]; other site 196627004103 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 196627004104 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 196627004105 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196627004106 Q-loop/lid; other site 196627004107 ABC transporter signature motif; other site 196627004108 Walker B; other site 196627004109 D-loop; other site 196627004110 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 196627004111 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 196627004112 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196627004113 Walker A/P-loop; other site 196627004114 ATP binding site [chemical binding]; other site 196627004115 Q-loop/lid; other site 196627004116 ABC transporter signature motif; other site 196627004117 Walker B; other site 196627004118 D-loop; other site 196627004119 H-loop/switch region; other site 196627004120 zinc transporter ZupT; Provisional; Region: PRK04201 196627004121 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 196627004122 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 196627004123 SEC-C motif; Region: SEC-C; cl19389 196627004124 Putative lysophospholipase; Region: Hydrolase_4; cl19140 196627004125 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 196627004126 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 196627004127 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 196627004128 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 196627004129 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 196627004130 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196627004131 nucleotide binding region [chemical binding]; other site 196627004132 ATP-binding site [chemical binding]; other site 196627004133 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 196627004134 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 196627004135 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 196627004136 phosphopeptide binding site; other site 196627004137 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 196627004138 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 196627004139 DNA binding residues [nucleotide binding] 196627004140 Uncharacterized conserved protein [Function unknown]; Region: COG1259 196627004141 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 196627004142 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 196627004143 DNA binding residues [nucleotide binding] 196627004144 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 196627004145 Mis12-Mtw1 protein family; Region: MIS13; pfam08202 196627004146 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 196627004147 Domain of unknown function DUF21; Region: DUF21; pfam01595 196627004148 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 196627004149 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 196627004150 Domain of unknown function DUF21; Region: DUF21; pfam01595 196627004151 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 196627004152 Transporter associated domain; Region: CorC_HlyC; smart01091 196627004153 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 196627004154 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 196627004155 ATP binding site [chemical binding]; other site 196627004156 putative Mg++ binding site [ion binding]; other site 196627004157 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196627004158 nucleotide binding region [chemical binding]; other site 196627004159 ATP-binding site [chemical binding]; other site 196627004160 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 196627004161 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 196627004162 FAD binding pocket [chemical binding]; other site 196627004163 FAD binding motif [chemical binding]; other site 196627004164 phosphate binding motif [ion binding]; other site 196627004165 NAD binding pocket [chemical binding]; other site 196627004166 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 196627004167 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 196627004168 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 196627004169 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 196627004170 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 196627004171 CoenzymeA binding site [chemical binding]; other site 196627004172 subunit interaction site [polypeptide binding]; other site 196627004173 PHB binding site; other site 196627004174 Methyltransferase domain; Region: Methyltransf_31; pfam13847 196627004175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196627004176 S-adenosylmethionine binding site [chemical binding]; other site 196627004177 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 196627004178 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 196627004179 Walker A/P-loop; other site 196627004180 ATP binding site [chemical binding]; other site 196627004181 Q-loop/lid; other site 196627004182 ABC transporter signature motif; other site 196627004183 Walker B; other site 196627004184 D-loop; other site 196627004185 H-loop/switch region; other site 196627004186 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 196627004187 ABC-2 type transporter; Region: ABC2_membrane; cl17235 196627004188 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 196627004189 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 196627004190 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 196627004191 putative active site [active] 196627004192 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 196627004193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196627004194 dimer interface [polypeptide binding]; other site 196627004195 conserved gate region; other site 196627004196 putative PBP binding loops; other site 196627004197 ABC-ATPase subunit interface; other site 196627004198 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 196627004199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196627004200 dimer interface [polypeptide binding]; other site 196627004201 conserved gate region; other site 196627004202 putative PBP binding loops; other site 196627004203 ABC-ATPase subunit interface; other site 196627004204 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 196627004205 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 196627004206 Walker A/P-loop; other site 196627004207 ATP binding site [chemical binding]; other site 196627004208 Q-loop/lid; other site 196627004209 ABC transporter signature motif; other site 196627004210 Walker B; other site 196627004211 D-loop; other site 196627004212 H-loop/switch region; other site 196627004213 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 196627004214 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 196627004215 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 196627004216 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196627004217 motif II; other site 196627004218 multifunctional thiamine-phosphate pyrophosphorylase/synthase/phosphomethylpyrimidine kinase; Provisional; Region: PRK09517 196627004219 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 196627004220 thiamine phosphate binding site [chemical binding]; other site 196627004221 active site 196627004222 pyrophosphate binding site [ion binding]; other site 196627004223 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 196627004224 dimer interface [polypeptide binding]; other site 196627004225 substrate binding site [chemical binding]; other site 196627004226 ATP binding site [chemical binding]; other site 196627004227 Putative transcription activator [Transcription]; Region: TenA; COG0819 196627004228 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 196627004229 substrate binding site [chemical binding]; other site 196627004230 multimerization interface [polypeptide binding]; other site 196627004231 ATP binding site [chemical binding]; other site 196627004232 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 196627004233 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 196627004234 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 196627004235 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 196627004236 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 196627004237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 196627004238 metabolite-proton symporter; Region: 2A0106; TIGR00883 196627004239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627004240 putative substrate translocation pore; other site 196627004241 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 196627004242 active site 196627004243 Predicted membrane protein [Function unknown]; Region: COG1971 196627004244 Domain of unknown function DUF; Region: DUF204; pfam02659 196627004245 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 196627004246 A new structural DNA glycosylase; Region: AlkD_like; cd06561 196627004247 active site 196627004248 high affinity sulphate transporter 1; Region: sulP; TIGR00815 196627004249 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 196627004250 Sulfate transporter family; Region: Sulfate_transp; pfam00916 196627004251 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 196627004252 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 196627004253 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 196627004254 Uncharacterized conserved protein [Function unknown]; Region: COG2353 196627004255 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 196627004256 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 196627004257 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 196627004258 Ligand binding site; other site 196627004259 Putative Catalytic site; other site 196627004260 DXD motif; other site 196627004261 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 196627004262 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 196627004263 putative active site [active] 196627004264 catalytic triad [active] 196627004265 putative dimer interface [polypeptide binding]; other site 196627004266 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 196627004267 Secretory lipase; Region: LIP; pfam03583 196627004268 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 196627004269 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 196627004270 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 196627004271 active site 196627004272 putative homodimer interface [polypeptide binding]; other site 196627004273 SAM binding site [chemical binding]; other site 196627004274 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 196627004275 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 196627004276 classical (c) SDRs; Region: SDR_c; cd05233 196627004277 NAD(P) binding site [chemical binding]; other site 196627004278 active site 196627004279 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 196627004280 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 196627004281 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 196627004282 active site 196627004283 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 196627004284 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 196627004285 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 196627004286 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196627004287 ATP binding site [chemical binding]; other site 196627004288 putative Mg++ binding site [ion binding]; other site 196627004289 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196627004290 nucleotide binding region [chemical binding]; other site 196627004291 ATP-binding site [chemical binding]; other site 196627004292 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 196627004293 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 196627004294 twin arginine translocase protein A; Provisional; Region: tatA; PRK00191 196627004295 Predicted transcriptional regulator [Transcription]; Region: COG2378 196627004296 WYL domain; Region: WYL; pfam13280 196627004297 Predicted transcriptional regulator [Transcription]; Region: COG2378 196627004298 WYL domain; Region: WYL; pfam13280 196627004299 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 196627004300 Pup-like protein; Region: Pup; pfam05639 196627004301 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 196627004302 proteasome ATPase; Region: pup_AAA; TIGR03689 196627004303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196627004304 Walker A motif; other site 196627004305 ATP binding site [chemical binding]; other site 196627004306 Walker B motif; other site 196627004307 arginine finger; other site 196627004308 tRNA methyltransferase complex GCD14 subunit N-term; Region: GCD14_N; pfam14801 196627004309 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 196627004310 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196627004311 S-adenosylmethionine binding site [chemical binding]; other site 196627004312 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 196627004313 active site 196627004314 metal binding site [ion binding]; metal-binding site 196627004315 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 196627004316 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196627004317 non-specific DNA binding site [nucleotide binding]; other site 196627004318 salt bridge; other site 196627004319 sequence-specific DNA binding site [nucleotide binding]; other site 196627004320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627004321 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196627004322 putative substrate translocation pore; other site 196627004323 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 196627004324 Aspartase; Region: Aspartase; cd01357 196627004325 active sites [active] 196627004326 tetramer interface [polypeptide binding]; other site 196627004327 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 196627004328 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 196627004329 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 196627004330 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 196627004331 homodimer interface [polypeptide binding]; other site 196627004332 putative metal binding site [ion binding]; other site 196627004333 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 196627004334 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196627004335 motif II; other site 196627004336 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 196627004337 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 196627004338 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 196627004339 substrate binding pocket [chemical binding]; other site 196627004340 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 196627004341 B12 binding site [chemical binding]; other site 196627004342 cobalt ligand [ion binding]; other site 196627004343 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 196627004344 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 196627004345 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 196627004346 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 196627004347 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 196627004348 active site 196627004349 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 196627004350 active site 196627004351 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 196627004352 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 196627004353 active site 196627004354 nucleotide binding site [chemical binding]; other site 196627004355 HIGH motif; other site 196627004356 KMSKS motif; other site 196627004357 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 196627004358 tRNA binding surface [nucleotide binding]; other site 196627004359 anticodon binding site; other site 196627004360 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 196627004361 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 196627004362 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 196627004363 active site 196627004364 catalytic tetrad [active] 196627004365 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 196627004366 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 196627004367 quinone interaction residues [chemical binding]; other site 196627004368 active site 196627004369 catalytic residues [active] 196627004370 FMN binding site [chemical binding]; other site 196627004371 substrate binding site [chemical binding]; other site 196627004372 Integrase core domain; Region: rve; pfam00665 196627004373 DDE domain; Region: DDE_Tnp_IS240; pfam13610 196627004374 Integrase core domain; Region: rve_3; pfam13683 196627004375 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 196627004376 substrate binding site [chemical binding]; other site 196627004377 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 196627004378 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 196627004379 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196627004380 Walker A/P-loop; other site 196627004381 ATP binding site [chemical binding]; other site 196627004382 Q-loop/lid; other site 196627004383 ABC transporter signature motif; other site 196627004384 Walker B; other site 196627004385 D-loop; other site 196627004386 H-loop/switch region; other site 196627004387 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 196627004388 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 196627004389 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196627004390 Q-loop/lid; other site 196627004391 ABC transporter signature motif; other site 196627004392 Walker B; other site 196627004393 D-loop; other site 196627004394 H-loop/switch region; other site 196627004395 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196627004396 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 196627004397 Coenzyme A binding pocket [chemical binding]; other site 196627004398 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 196627004399 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 196627004400 Walker A; other site 196627004401 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 196627004402 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 196627004403 active site 196627004404 substrate binding site [chemical binding]; other site 196627004405 coenzyme B12 binding site [chemical binding]; other site 196627004406 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 196627004407 B12 binding site [chemical binding]; other site 196627004408 cobalt ligand [ion binding]; other site 196627004409 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 196627004410 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 196627004411 heterodimer interface [polypeptide binding]; other site 196627004412 substrate interaction site [chemical binding]; other site 196627004413 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Region: Sbm; COG2185 196627004414 Uncharacterized conserved protein [Function unknown]; Region: COG0398 196627004415 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 196627004416 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 196627004417 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 196627004418 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 196627004419 ferrochelatase; Reviewed; Region: hemH; PRK00035 196627004420 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 196627004421 C-terminal domain interface [polypeptide binding]; other site 196627004422 active site 196627004423 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 196627004424 active site 196627004425 N-terminal domain interface [polypeptide binding]; other site 196627004426 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 196627004427 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 196627004428 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 196627004429 NlpC/P60 family; Region: NLPC_P60; pfam00877 196627004430 aconitate hydratase; Validated; Region: PRK09277 196627004431 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 196627004432 substrate binding site [chemical binding]; other site 196627004433 ligand binding site [chemical binding]; other site 196627004434 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 196627004435 substrate binding site [chemical binding]; other site 196627004436 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 196627004437 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 196627004438 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 196627004439 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 196627004440 catalytic triad [active] 196627004441 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196627004442 NAD(P) binding site [chemical binding]; other site 196627004443 active site 196627004444 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 196627004445 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 196627004446 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 196627004447 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 196627004448 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 196627004449 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 196627004450 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196627004451 motif II; other site 196627004452 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 196627004453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4762 196627004454 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 196627004455 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 196627004456 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 196627004457 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 196627004458 DNA binding site [nucleotide binding] 196627004459 Int/Topo IB signature motif; other site 196627004460 active site 196627004461 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 196627004462 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 196627004463 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 196627004464 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 196627004465 Integrase core domain; Region: rve; pfam00665 196627004466 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 196627004467 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 196627004468 trimerization site [polypeptide binding]; other site 196627004469 active site 196627004470 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 196627004471 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 196627004472 catalytic residue [active] 196627004473 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 196627004474 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 196627004475 Walker A/P-loop; other site 196627004476 ATP binding site [chemical binding]; other site 196627004477 Q-loop/lid; other site 196627004478 ABC transporter signature motif; other site 196627004479 Walker B; other site 196627004480 D-loop; other site 196627004481 H-loop/switch region; other site 196627004482 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 196627004483 FeS assembly protein SufD; Region: sufD; TIGR01981 196627004484 FeS assembly protein SufB; Region: sufB; TIGR01980 196627004485 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 196627004486 Predicted transcriptional regulator [Transcription]; Region: COG2345 196627004487 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 196627004488 putative DNA binding site [nucleotide binding]; other site 196627004489 putative Zn2+ binding site [ion binding]; other site 196627004490 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 196627004491 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 196627004492 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 196627004493 Walker A/P-loop; other site 196627004494 ATP binding site [chemical binding]; other site 196627004495 Q-loop/lid; other site 196627004496 ABC transporter signature motif; other site 196627004497 Walker B; other site 196627004498 D-loop; other site 196627004499 H-loop/switch region; other site 196627004500 ABC-2 type transporter; Region: ABC2_membrane; cl17235 196627004501 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 196627004502 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 196627004503 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4951 196627004504 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 196627004505 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196627004506 ATP binding site [chemical binding]; other site 196627004507 putative Mg++ binding site [ion binding]; other site 196627004508 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196627004509 nucleotide binding region [chemical binding]; other site 196627004510 ATP-binding site [chemical binding]; other site 196627004511 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 196627004512 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 196627004513 NADP binding site [chemical binding]; other site 196627004514 dimer interface [polypeptide binding]; other site 196627004515 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 196627004516 putative active site [active] 196627004517 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 196627004518 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 196627004519 TPP-binding site [chemical binding]; other site 196627004520 dimer interface [polypeptide binding]; other site 196627004521 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 196627004522 PYR/PP interface [polypeptide binding]; other site 196627004523 dimer interface [polypeptide binding]; other site 196627004524 TPP binding site [chemical binding]; other site 196627004525 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 196627004526 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 196627004527 putative active site [active] 196627004528 catalytic residue [active] 196627004529 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 196627004530 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 196627004531 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 196627004532 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 196627004533 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 196627004534 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 196627004535 putative active site [active] 196627004536 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 196627004537 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 196627004538 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 196627004539 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 196627004540 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 196627004541 ornithine cyclodeaminase; Validated; Region: PRK06199 196627004542 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 196627004543 ammonium transporter; Region: amt; TIGR00836 196627004544 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 196627004545 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 196627004546 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 196627004547 substrate binding site [chemical binding]; other site 196627004548 dimer interface [polypeptide binding]; other site 196627004549 catalytic triad [active] 196627004550 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 196627004551 substrate binding site [chemical binding]; other site 196627004552 hinge regions; other site 196627004553 ADP binding site [chemical binding]; other site 196627004554 catalytic site [active] 196627004555 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 196627004556 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 196627004557 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 196627004558 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 196627004559 WhiA N-terminal LAGLIDADG-like domain; Region: WhiA_N; pfam10298 196627004560 WhiA LAGLIDADG-like domain; Region: LAGLIDADG_WhiA; pfam14527 196627004561 WhiA C-terminal HTH domain; Region: HTH_WhiA; pfam02650 196627004562 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 196627004563 phosphate binding site [ion binding]; other site 196627004564 putative substrate binding pocket [chemical binding]; other site 196627004565 dimer interface [polypeptide binding]; other site 196627004566 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 196627004567 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 196627004568 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 196627004569 GIY-YIG motif/motif A; other site 196627004570 active site 196627004571 catalytic site [active] 196627004572 putative DNA binding site [nucleotide binding]; other site 196627004573 metal binding site [ion binding]; metal-binding site 196627004574 UvrB/uvrC motif; Region: UVR; pfam02151 196627004575 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 196627004576 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 196627004577 Bacterial PH domain; Region: bPH_6; pfam10756 196627004578 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 196627004579 homopentamer interface [polypeptide binding]; other site 196627004580 active site 196627004581 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 196627004582 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 196627004583 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 196627004584 dimerization interface [polypeptide binding]; other site 196627004585 active site 196627004586 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 196627004587 Lumazine binding domain; Region: Lum_binding; pfam00677 196627004588 Lumazine binding domain; Region: Lum_binding; pfam00677 196627004589 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 196627004590 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 196627004591 catalytic motif [active] 196627004592 Zn binding site [ion binding]; other site 196627004593 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 196627004594 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 196627004595 substrate binding site [chemical binding]; other site 196627004596 hexamer interface [polypeptide binding]; other site 196627004597 metal binding site [ion binding]; metal-binding site 196627004598 16S rRNA methyltransferase B; Provisional; Region: PRK14902 196627004599 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 196627004600 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196627004601 S-adenosylmethionine binding site [chemical binding]; other site 196627004602 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 196627004603 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 196627004604 putative active site [active] 196627004605 substrate binding site [chemical binding]; other site 196627004606 putative cosubstrate binding site; other site 196627004607 catalytic site [active] 196627004608 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 196627004609 substrate binding site [chemical binding]; other site 196627004610 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 196627004611 active site 196627004612 catalytic residues [active] 196627004613 metal binding site [ion binding]; metal-binding site 196627004614 primosome assembly protein PriA; Provisional; Region: PRK14873 196627004615 S-adenosylmethionine synthetase; Validated; Region: PRK05250 196627004616 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 196627004617 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 196627004618 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 196627004619 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 196627004620 Flavoprotein; Region: Flavoprotein; cl19190 196627004621 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 196627004622 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 196627004623 Guanylate kinase; Region: Guanylate_kin; pfam00625 196627004624 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 196627004625 catalytic site [active] 196627004626 G-X2-G-X-G-K; other site 196627004627 RNA polymerase factor sigma-70; Validated; Region: PRK08241 196627004628 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 196627004629 active site 196627004630 dimer interface [polypeptide binding]; other site 196627004631 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 196627004632 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 196627004633 ATP-grasp domain; Region: ATP-grasp_4; cl17255 196627004634 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 196627004635 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 196627004636 ATP-grasp domain; Region: ATP-grasp_4; cl17255 196627004637 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 196627004638 IMP binding site; other site 196627004639 dimer interface [polypeptide binding]; other site 196627004640 interdomain contacts; other site 196627004641 partial ornithine binding site; other site 196627004642 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 196627004643 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 196627004644 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 196627004645 catalytic site [active] 196627004646 subunit interface [polypeptide binding]; other site 196627004647 dihydroorotase; Validated; Region: pyrC; PRK09357 196627004648 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 196627004649 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 196627004650 active site 196627004651 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 196627004652 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 196627004653 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 196627004654 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 196627004655 active site 196627004656 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 196627004657 putative hydrophobic ligand binding site [chemical binding]; other site 196627004658 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 196627004659 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 196627004660 putative NAD(P) binding site [chemical binding]; other site 196627004661 putative active site [active] 196627004662 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 196627004663 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 196627004664 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 196627004665 Transcription termination factor [Transcription]; Region: NusB; COG0781 196627004666 putative RNA binding site [nucleotide binding]; other site 196627004667 elongation factor P; Validated; Region: PRK00529 196627004668 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 196627004669 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 196627004670 RNA binding site [nucleotide binding]; other site 196627004671 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 196627004672 RNA binding site [nucleotide binding]; other site 196627004673 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 196627004674 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 196627004675 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 196627004676 active site 196627004677 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 196627004678 active site 196627004679 dimer interface [polypeptide binding]; other site 196627004680 metal binding site [ion binding]; metal-binding site 196627004681 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 196627004682 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 196627004683 ADP binding site [chemical binding]; other site 196627004684 magnesium binding site [ion binding]; other site 196627004685 putative shikimate binding site; other site 196627004686 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 196627004687 Tetramer interface [polypeptide binding]; other site 196627004688 active site 196627004689 FMN-binding site [chemical binding]; other site 196627004690 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 196627004691 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 196627004692 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 196627004693 dimerization interface [polypeptide binding]; other site 196627004694 putative DNA binding site [nucleotide binding]; other site 196627004695 putative Zn2+ binding site [ion binding]; other site 196627004696 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 196627004697 ABC-ATPase subunit interface; other site 196627004698 dimer interface [polypeptide binding]; other site 196627004699 putative PBP binding regions; other site 196627004700 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 196627004701 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 196627004702 putative ligand binding residues [chemical binding]; other site 196627004703 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 196627004704 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 196627004705 Walker A/P-loop; other site 196627004706 ATP binding site [chemical binding]; other site 196627004707 Q-loop/lid; other site 196627004708 ABC transporter signature motif; other site 196627004709 Walker B; other site 196627004710 D-loop; other site 196627004711 H-loop/switch region; other site 196627004712 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 196627004713 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 196627004714 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 196627004715 shikimate binding site; other site 196627004716 NAD(P) binding site [chemical binding]; other site 196627004717 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 196627004718 dimerization interface [polypeptide binding]; other site 196627004719 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 196627004720 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 196627004721 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 196627004722 motif 1; other site 196627004723 active site 196627004724 motif 2; other site 196627004725 motif 3; other site 196627004726 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 196627004727 DHHA1 domain; Region: DHHA1; pfam02272 196627004728 recombination factor protein RarA; Reviewed; Region: PRK13342 196627004729 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196627004730 Walker A motif; other site 196627004731 ATP binding site [chemical binding]; other site 196627004732 Walker B motif; other site 196627004733 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 196627004734 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 196627004735 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 196627004736 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 196627004737 dimer interface [polypeptide binding]; other site 196627004738 anticodon binding site; other site 196627004739 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 196627004740 homodimer interface [polypeptide binding]; other site 196627004741 motif 1; other site 196627004742 active site 196627004743 motif 2; other site 196627004744 GAD domain; Region: GAD; pfam02938 196627004745 motif 3; other site 196627004746 Predicted metalloprotease [General function prediction only]; Region: COG2321 196627004747 DEAD-like helicases superfamily; Region: DEXDc; smart00487 196627004748 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196627004749 ATP binding site [chemical binding]; other site 196627004750 putative Mg++ binding site [ion binding]; other site 196627004751 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196627004752 nucleotide binding region [chemical binding]; other site 196627004753 ATP-binding site [chemical binding]; other site 196627004754 Predicted membrane protein [Function unknown]; Region: COG1511 196627004755 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 196627004756 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 196627004757 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 196627004758 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 196627004759 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196627004760 Q-loop/lid; other site 196627004761 ABC transporter signature motif; other site 196627004762 Walker B; other site 196627004763 D-loop; other site 196627004764 H-loop/switch region; other site 196627004765 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 196627004766 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 196627004767 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 196627004768 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 196627004769 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 196627004770 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 196627004771 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 196627004772 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 196627004773 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 196627004774 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 196627004775 dimer interface [polypeptide binding]; other site 196627004776 motif 1; other site 196627004777 active site 196627004778 motif 2; other site 196627004779 motif 3; other site 196627004780 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 196627004781 anticodon binding site; other site 196627004782 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 196627004783 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 196627004784 active site 196627004785 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 196627004786 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 196627004787 Zn2+ binding site [ion binding]; other site 196627004788 Mg2+ binding site [ion binding]; other site 196627004789 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 196627004790 synthetase active site [active] 196627004791 NTP binding site [chemical binding]; other site 196627004792 metal binding site [ion binding]; metal-binding site 196627004793 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 196627004794 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 196627004795 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 196627004796 active site 196627004797 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 196627004798 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 196627004799 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 196627004800 Protein export membrane protein; Region: SecD_SecF; pfam02355 196627004801 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 196627004802 Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl17217 196627004803 MMPL family; Region: MMPL; cl14618 196627004804 Preprotein translocase subunit; Region: YajC; pfam02699 196627004805 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 196627004806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196627004807 Walker A motif; other site 196627004808 ATP binding site [chemical binding]; other site 196627004809 Walker B motif; other site 196627004810 arginine finger; other site 196627004811 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 196627004812 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632 196627004813 RuvA N terminal domain; Region: RuvA_N; pfam01330 196627004814 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 196627004815 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 196627004816 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 196627004817 active site 196627004818 putative DNA-binding cleft [nucleotide binding]; other site 196627004819 dimer interface [polypeptide binding]; other site 196627004820 hypothetical protein; Validated; Region: PRK00110 196627004821 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 196627004822 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 196627004823 active site 196627004824 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 196627004825 catalytic triad [active] 196627004826 dimer interface [polypeptide binding]; other site 196627004827 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 196627004828 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 196627004829 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 196627004830 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 196627004831 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 196627004832 putative acyl-acceptor binding pocket; other site 196627004833 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 196627004834 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 196627004835 nucleotide binding site/active site [active] 196627004836 HIT family signature motif; other site 196627004837 catalytic residue [active] 196627004838 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 196627004839 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 196627004840 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 196627004841 active site 196627004842 dimer interface [polypeptide binding]; other site 196627004843 motif 1; other site 196627004844 motif 2; other site 196627004845 motif 3; other site 196627004846 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 196627004847 anticodon binding site; other site 196627004848 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196627004849 Walker A/P-loop; other site 196627004850 ATP binding site [chemical binding]; other site 196627004851 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 196627004852 Q-loop/lid; other site 196627004853 Copper(I)-binding protein [Inorganic ion transport and metabolism]; Region: COG2847 196627004854 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 196627004855 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 196627004856 nucleotide binding site [chemical binding]; other site 196627004857 transport protein TonB; Provisional; Region: PRK10819 196627004858 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 196627004859 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196627004860 Coenzyme A binding pocket [chemical binding]; other site 196627004861 Phage tail protein; Region: Sipho_tail; cl17486 196627004862 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 196627004863 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196627004864 Walker A/P-loop; other site 196627004865 ATP binding site [chemical binding]; other site 196627004866 ABC transporter signature motif; other site 196627004867 Walker B; other site 196627004868 D-loop; other site 196627004869 H-loop/switch region; other site 196627004870 Phosphotransferase enzyme family; Region: APH; pfam01636 196627004871 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 196627004872 Flavoprotein; Region: Flavoprotein; cl19190 196627004873 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236 196627004874 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 196627004875 Cadherin repeat-like domain; Region: CA_like; cl15786 196627004876 ATP synthase protein 8; Region: ATP-synt_8; cl03008 196627004877 multiple promoter invertase; Provisional; Region: mpi; PRK13413 196627004878 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 196627004879 catalytic residues [active] 196627004880 catalytic nucleophile [active] 196627004881 Presynaptic Site I dimer interface [polypeptide binding]; other site 196627004882 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 196627004883 Synaptic Flat tetramer interface [polypeptide binding]; other site 196627004884 Synaptic Site I dimer interface [polypeptide binding]; other site 196627004885 DNA binding site [nucleotide binding] 196627004886 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569 196627004887 DNA-binding interface [nucleotide binding]; DNA binding site 196627004888 Trypsin; Region: Trypsin; pfam00089 196627004889 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 196627004890 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 196627004891 Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453 196627004892 Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or...; Region: DSPc; cl00053 196627004893 active site 196627004894 catalytic residues [active] 196627004895 Transcriptional regulators [Transcription]; Region: FadR; COG2186 196627004896 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 196627004897 DNA-binding site [nucleotide binding]; DNA binding site 196627004898 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 196627004899 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 196627004900 putative transposase OrfB; Reviewed; Region: PHA02517 196627004901 HTH-like domain; Region: HTH_21; pfam13276 196627004902 Integrase core domain; Region: rve; pfam00665 196627004903 Integrase core domain; Region: rve_3; pfam13683 196627004904 Protein of unknown function (DUF2699); Region: DUF2699; pfam10919 196627004905 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 196627004906 Transposase; Region: HTH_Tnp_1; pfam01527 196627004907 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 196627004908 Single-stranded DNA-specific exonuclease [DNA replication, recombination, and repair]; Region: RecJ; COG0608 196627004909 DHH family; Region: DHH; pfam01368 196627004910 Phage associated DNA primase [General function prediction only]; Region: COG3378 196627004911 D5 N terminal like; Region: D5_N; smart00885 196627004912 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 196627004913 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 196627004914 VRR-NUC domain; Region: VRR_NUC; pfam08774 196627004915 phospholipid-translocating P-type ATPase, flippase; Region: ATPase-Plipid; TIGR01652 196627004916 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 196627004917 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196627004918 ATP binding site [chemical binding]; other site 196627004919 putative Mg++ binding site [ion binding]; other site 196627004920 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 196627004921 Lsr2; Region: Lsr2; pfam11774 196627004922 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 196627004923 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 196627004924 MoxR-like ATPases [General function prediction only]; Region: COG0714 196627004925 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196627004926 Walker A motif; other site 196627004927 ATP binding site [chemical binding]; other site 196627004928 Walker B motif; other site 196627004929 arginine finger; other site 196627004930 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 196627004931 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 196627004932 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196627004933 Walker A motif; other site 196627004934 ATP binding site [chemical binding]; other site 196627004935 Walker B motif; other site 196627004936 arginine finger; other site 196627004937 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196627004938 Walker A motif; other site 196627004939 ATP binding site [chemical binding]; other site 196627004940 Walker B motif; other site 196627004941 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 196627004942 Part of AAA domain; Region: AAA_19; pfam13245 196627004943 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 196627004944 Drosophila Retinin like protein; Region: Retinin_C; pfam04527 196627004945 NUDIX domain; Region: NUDIX; pfam00293 196627004946 nudix motif; other site 196627004947 deoxynucleoside monophosphate kinase; Provisional; Region: 1; PHA02575 196627004948 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208 196627004949 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 196627004950 Largest subunit of RNA polymerase (RNAP), N-terminal domain; Region: RNAP_largest_subunit_N; cl19114 196627004951 active site region [active] 196627004952 catalytic site [active] 196627004953 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 196627004954 cofactor binding site; other site 196627004955 DNA binding site [nucleotide binding] 196627004956 substrate interaction site [chemical binding]; other site 196627004957 Putative catalytic domain of type II restriction enzyme NgoFVII and similar proteins; Region: PLDc_RE_NgoFVII; cd09177 196627004958 PLD-like domain; Region: PLDc_2; pfam13091 196627004959 putative homodimer interface [polypeptide binding]; other site 196627004960 putative active site [active] 196627004961 catalytic site [active] 196627004962 DEAD-like helicases superfamily; Region: DEXDc; smart00487 196627004963 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196627004964 ATP binding site [chemical binding]; other site 196627004965 putative Mg++ binding site [ion binding]; other site 196627004966 Z1 domain; Region: Z1; pfam10593 196627004967 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 196627004968 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 196627004969 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 196627004970 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 196627004971 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 196627004972 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 196627004973 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 196627004974 Walker B motif; other site 196627004975 Bacterial protein of unknown function (DUF885); Region: DUF885; cl19872 196627004976 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196627004977 Walker A motif; other site 196627004978 ATP binding site [chemical binding]; other site 196627004979 Walker B motif; other site 196627004980 arginine finger; other site 196627004981 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196627004982 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 196627004983 Walker A motif; other site 196627004984 ATP binding site [chemical binding]; other site 196627004985 Walker B motif; other site 196627004986 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 196627004987 Protein of unknown function (DUF456); Region: DUF456; pfam04306 196627004988 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 196627004989 Cytidylyltransferase family; Region: CTP_transf_1; cl17467 196627004990 IncA protein; Region: IncA; pfam04156 196627004991 Hantavirus nucleocapsid protein; Region: Hanta_nucleocap; pfam00846 196627004992 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 196627004993 GIY-YIG catalytic domain; Region: GIY-YIG; pfam01541 196627004994 GIY-YIG motif/motif A; other site 196627004995 active site 196627004996 catalytic site [active] 196627004997 metal binding site [ion binding]; metal-binding site 196627004998 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 196627004999 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 196627005000 RatA-like protein; Provisional; Region: PRK15316 196627005001 ARC105 or Med15 subunit of Mediator complex non-fungal; Region: Med15; pfam09606 196627005002 Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651 196627005003 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196627005004 non-specific DNA binding site [nucleotide binding]; other site 196627005005 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 196627005006 salt bridge; other site 196627005007 sequence-specific DNA binding site [nucleotide binding]; other site 196627005008 chromosomal replication initiation protein; Provisional; Region: PRK12422 196627005009 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 196627005010 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 196627005011 active site 196627005012 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 196627005013 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 196627005014 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 196627005015 LGFP repeat; Region: LGFP; pfam08310 196627005016 LGFP repeat; Region: LGFP; pfam08310 196627005017 LGFP repeat; Region: LGFP; pfam08310 196627005018 AAA-like domain; Region: AAA_10; pfam12846 196627005019 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 196627005020 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 196627005021 active site 196627005022 putative interdomain interaction site [polypeptide binding]; other site 196627005023 putative metal-binding site [ion binding]; other site 196627005024 putative nucleotide binding site [chemical binding]; other site 196627005025 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 196627005026 domain I; other site 196627005027 DNA binding groove [nucleotide binding] 196627005028 phosphate binding site [ion binding]; other site 196627005029 domain II; other site 196627005030 domain III; other site 196627005031 nucleotide binding site [chemical binding]; other site 196627005032 catalytic site [active] 196627005033 domain IV; other site 196627005034 DEAD-like helicases superfamily; Region: DEXDc; smart00487 196627005035 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196627005036 ATP binding site [chemical binding]; other site 196627005037 putative Mg++ binding site [ion binding]; other site 196627005038 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 196627005039 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 196627005040 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 196627005041 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 196627005042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4815 196627005043 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 196627005044 LGFP repeat; Region: LGFP; pfam08310 196627005045 LGFP repeat; Region: LGFP; pfam08310 196627005046 LGFP repeat; Region: LGFP; pfam08310 196627005047 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 196627005048 Staphylococcal nuclease homologues; Region: SNc; smart00318 196627005049 Staphylococcal nuclease homologue; Region: SNase; cl00140 196627005050 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 196627005051 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 196627005052 dimer interface [polypeptide binding]; other site 196627005053 ssDNA binding site [nucleotide binding]; other site 196627005054 tetramer (dimer of dimers) interface [polypeptide binding]; other site 196627005055 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 196627005056 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 196627005057 Domain of unknown function (DUF4313); Region: DUF4313; pfam14190 196627005058 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 196627005059 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 196627005060 active site 196627005061 catalytic residues [active] 196627005062 DNA binding site [nucleotide binding] 196627005063 Int/Topo IB signature motif; other site 196627005064 Integrase core domain; Region: rve; pfam00665 196627005065 HTH-like domain; Region: HTH_21; pfam13276 196627005066 Integrase core domain; Region: rve; pfam00665 196627005067 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 196627005068 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 196627005069 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 196627005070 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 196627005071 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 196627005072 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 196627005073 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4815 196627005074 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 196627005075 LGFP repeat; Region: LGFP; pfam08310 196627005076 LGFP repeat; Region: LGFP; pfam08310 196627005077 LGFP repeat; Region: LGFP; pfam08310 196627005078 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 196627005079 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 196627005080 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 196627005081 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 196627005082 hypothetical protein; Provisional; Region: PRK14059 196627005083 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 196627005084 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 196627005085 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 196627005086 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 196627005087 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 196627005088 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 196627005089 catalytic site [active] 196627005090 putative active site [active] 196627005091 putative substrate binding site [chemical binding]; other site 196627005092 HRDC domain; Region: HRDC; pfam00570 196627005093 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 196627005094 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 196627005095 TPP-binding site; other site 196627005096 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 196627005097 PYR/PP interface [polypeptide binding]; other site 196627005098 dimer interface [polypeptide binding]; other site 196627005099 TPP binding site [chemical binding]; other site 196627005100 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 196627005101 TRAM domain; Region: TRAM; pfam01938 196627005102 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 196627005103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 196627005104 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 196627005105 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 196627005106 trimer interface [polypeptide binding]; other site 196627005107 active site 196627005108 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 196627005109 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 196627005110 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 196627005111 active site 196627005112 dimerization interface [polypeptide binding]; other site 196627005113 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 196627005114 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 196627005115 nucleotide binding site [chemical binding]; other site 196627005116 RNA polymerase sigma factor; Provisional; Region: PRK05901 196627005117 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 196627005118 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 196627005119 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 196627005120 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 196627005121 DNA binding residues [nucleotide binding] 196627005122 Predicted membrane protein [Function unknown]; Region: COG2311 196627005123 Protein of unknown function (DUF418); Region: DUF418; cl12135 196627005124 Protein of unknown function (DUF418); Region: DUF418; cl12135 196627005125 Tic20-like protein; Region: Tic20; pfam09685 196627005126 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 196627005127 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196627005128 ATP binding site [chemical binding]; other site 196627005129 putative Mg++ binding site [ion binding]; other site 196627005130 Cwf15/Cwc15 cell cycle control protein; Region: Cwf_Cwc_15; pfam04889 196627005131 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 196627005132 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 196627005133 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 196627005134 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196627005135 S-adenosylmethionine binding site [chemical binding]; other site 196627005136 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 196627005137 putative active site [active] 196627005138 dimerization interface [polypeptide binding]; other site 196627005139 putative tRNAtyr binding site [nucleotide binding]; other site 196627005140 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 196627005141 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 196627005142 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 196627005143 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 196627005144 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 196627005145 DNA binding residues [nucleotide binding] 196627005146 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 196627005147 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 196627005148 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 196627005149 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 196627005150 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 196627005151 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 196627005152 NAD binding site [chemical binding]; other site 196627005153 homodimer interface [polypeptide binding]; other site 196627005154 active site 196627005155 substrate binding site [chemical binding]; other site 196627005156 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 196627005157 PAC2 family; Region: PAC2; pfam09754 196627005158 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 196627005159 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196627005160 ATP binding site [chemical binding]; other site 196627005161 putative Mg++ binding site [ion binding]; other site 196627005162 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196627005163 nucleotide binding region [chemical binding]; other site 196627005164 ATP-binding site [chemical binding]; other site 196627005165 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 196627005166 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 196627005167 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 196627005168 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 196627005169 dimerization interface [polypeptide binding]; other site 196627005170 Predicted integral membrane protein [Function unknown]; Region: COG5473 196627005171 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 196627005172 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196627005173 ATP binding site [chemical binding]; other site 196627005174 putative Mg++ binding site [ion binding]; other site 196627005175 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196627005176 nucleotide binding region [chemical binding]; other site 196627005177 ATP-binding site [chemical binding]; other site 196627005178 Helicase associated domain (HA2); Region: HA2; pfam04408 196627005179 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 196627005180 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 196627005181 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 196627005182 ATP cone domain; Region: ATP-cone; pfam03477 196627005183 LexA repressor; Validated; Region: PRK00215 196627005184 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 196627005185 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 196627005186 Catalytic site [active] 196627005187 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 196627005188 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 196627005189 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 196627005190 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 196627005191 substrate binding site [chemical binding]; other site 196627005192 ATP binding site [chemical binding]; other site 196627005193 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 196627005194 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 196627005195 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 196627005196 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 196627005197 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 196627005198 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 196627005199 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 196627005200 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 196627005201 putative substrate binding site [chemical binding]; other site 196627005202 putative ATP binding site [chemical binding]; other site 196627005203 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 196627005204 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 196627005205 active site 196627005206 phosphorylation site [posttranslational modification] 196627005207 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 196627005208 active site 196627005209 P-loop; other site 196627005210 phosphorylation site [posttranslational modification] 196627005211 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 196627005212 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 196627005213 dimerization domain swap beta strand [polypeptide binding]; other site 196627005214 regulatory protein interface [polypeptide binding]; other site 196627005215 active site 196627005216 regulatory phosphorylation site [posttranslational modification]; other site 196627005217 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 196627005218 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 196627005219 Sulfate transporter family; Region: Sulfate_transp; cl19250 196627005220 GTPases [General function prediction only]; Region: HflX; COG2262 196627005221 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 196627005222 HflX GTPase family; Region: HflX; cd01878 196627005223 G1 box; other site 196627005224 GTP/Mg2+ binding site [chemical binding]; other site 196627005225 Switch I region; other site 196627005226 G2 box; other site 196627005227 G3 box; other site 196627005228 Switch II region; other site 196627005229 G4 box; other site 196627005230 G5 box; other site 196627005231 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 196627005232 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 196627005233 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 196627005234 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 196627005235 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 196627005236 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 196627005237 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 196627005238 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 196627005239 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 196627005240 Transmembrane protein family 171; Region: TMEM171; pfam15471 196627005241 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 196627005242 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 196627005243 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 196627005244 FeS/SAM binding site; other site 196627005245 TRAM domain; Region: TRAM; cl01282 196627005246 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 196627005247 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 196627005248 Walker A/P-loop; other site 196627005249 ATP binding site [chemical binding]; other site 196627005250 Q-loop/lid; other site 196627005251 ABC transporter signature motif; other site 196627005252 Walker B; other site 196627005253 D-loop; other site 196627005254 H-loop/switch region; other site 196627005255 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 196627005256 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 196627005257 substrate binding pocket [chemical binding]; other site 196627005258 membrane-bound complex binding site; other site 196627005259 hinge residues; other site 196627005260 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 196627005261 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196627005262 dimer interface [polypeptide binding]; other site 196627005263 conserved gate region; other site 196627005264 putative PBP binding loops; other site 196627005265 ABC-ATPase subunit interface; other site 196627005266 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 196627005267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196627005268 dimer interface [polypeptide binding]; other site 196627005269 conserved gate region; other site 196627005270 putative PBP binding loops; other site 196627005271 ABC-ATPase subunit interface; other site 196627005272 Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137 196627005273 recombinase A; Provisional; Region: recA; PRK09354 196627005274 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 196627005275 hexamer interface [polypeptide binding]; other site 196627005276 Walker A motif; other site 196627005277 ATP binding site [chemical binding]; other site 196627005278 Walker B motif; other site 196627005279 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 196627005280 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 196627005281 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 196627005282 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 196627005283 ATP binding site [chemical binding]; other site 196627005284 Q-loop/lid; other site 196627005285 ABC transporter signature motif; other site 196627005286 Walker B; other site 196627005287 D-loop; other site 196627005288 H-loop/switch region; other site 196627005289 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 196627005290 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 196627005291 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196627005292 non-specific DNA binding site [nucleotide binding]; other site 196627005293 salt bridge; other site 196627005294 sequence-specific DNA binding site [nucleotide binding]; other site 196627005295 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 196627005296 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 196627005297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 196627005298 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 196627005299 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 196627005300 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 196627005301 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 196627005302 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 196627005303 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 196627005304 DinB superfamily; Region: DinB_2; cl19195 196627005305 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 196627005306 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 196627005307 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 196627005308 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 196627005309 dimer interface [polypeptide binding]; other site 196627005310 active site 196627005311 catalytic residue [active] 196627005312 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 196627005313 dihydrodipicolinate reductase; Provisional; Region: PRK00048 196627005314 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 196627005315 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 196627005316 large tegument protein UL36; Provisional; Region: PHA03247 196627005317 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 196627005318 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 196627005319 oligomer interface [polypeptide binding]; other site 196627005320 RNA binding site [nucleotide binding]; other site 196627005321 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 196627005322 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 196627005323 RNase E interface [polypeptide binding]; other site 196627005324 trimer interface [polypeptide binding]; other site 196627005325 active site 196627005326 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 196627005327 putative nucleic acid binding region [nucleotide binding]; other site 196627005328 G-X-X-G motif; other site 196627005329 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 196627005330 RNA binding site [nucleotide binding]; other site 196627005331 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 196627005332 16S/18S rRNA binding site [nucleotide binding]; other site 196627005333 S13e-L30e interaction site [polypeptide binding]; other site 196627005334 25S rRNA binding site [nucleotide binding]; other site 196627005335 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 196627005336 active site 196627005337 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 196627005338 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 196627005339 active site 196627005340 Riboflavin kinase; Region: Flavokinase; smart00904 196627005341 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 196627005342 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 196627005343 RNA binding site [nucleotide binding]; other site 196627005344 active site 196627005345 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 196627005346 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 196627005347 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 196627005348 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 196627005349 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 196627005350 active site 196627005351 metal binding site [ion binding]; metal-binding site 196627005352 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 196627005353 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 196627005354 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 196627005355 DHH family; Region: DHH; pfam01368 196627005356 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 196627005357 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 196627005358 translation initiation factor IF-2; Validated; Region: infB; PRK05306 196627005359 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 196627005360 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 196627005361 G1 box; other site 196627005362 putative GEF interaction site [polypeptide binding]; other site 196627005363 GTP/Mg2+ binding site [chemical binding]; other site 196627005364 Switch I region; other site 196627005365 G2 box; other site 196627005366 G3 box; other site 196627005367 Switch II region; other site 196627005368 G4 box; other site 196627005369 G5 box; other site 196627005370 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 196627005371 Translation-initiation factor 2; Region: IF-2; pfam11987 196627005372 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 196627005373 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 196627005374 putative RNA binding cleft [nucleotide binding]; other site 196627005375 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 196627005376 NusA N-terminal domain; Region: NusA_N; pfam08529 196627005377 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 196627005378 RNA binding site [nucleotide binding]; other site 196627005379 homodimer interface [polypeptide binding]; other site 196627005380 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 196627005381 G-X-X-G motif; other site 196627005382 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 196627005383 G-X-X-G motif; other site 196627005384 ribosome maturation protein RimP; Reviewed; Region: PRK00092 196627005385 heptamer interface [polypeptide binding]; other site 196627005386 Sm1 motif; other site 196627005387 hexamer interface [polypeptide binding]; other site 196627005388 RNA binding site [nucleotide binding]; other site 196627005389 Sm2 motif; other site 196627005390 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 196627005391 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 196627005392 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 196627005393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196627005394 dimer interface [polypeptide binding]; other site 196627005395 conserved gate region; other site 196627005396 putative PBP binding loops; other site 196627005397 ABC-ATPase subunit interface; other site 196627005398 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 196627005399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196627005400 dimer interface [polypeptide binding]; other site 196627005401 conserved gate region; other site 196627005402 putative PBP binding loops; other site 196627005403 ABC-ATPase subunit interface; other site 196627005404 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 196627005405 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 196627005406 Walker A/P-loop; other site 196627005407 ATP binding site [chemical binding]; other site 196627005408 Q-loop/lid; other site 196627005409 ABC transporter signature motif; other site 196627005410 Walker B; other site 196627005411 D-loop; other site 196627005412 H-loop/switch region; other site 196627005413 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 196627005414 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 196627005415 Walker A/P-loop; other site 196627005416 ATP binding site [chemical binding]; other site 196627005417 Q-loop/lid; other site 196627005418 ABC transporter signature motif; other site 196627005419 Walker B; other site 196627005420 D-loop; other site 196627005421 H-loop/switch region; other site 196627005422 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 196627005423 prolyl-tRNA synthetase; Provisional; Region: PRK09194 196627005424 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 196627005425 dimer interface [polypeptide binding]; other site 196627005426 motif 1; other site 196627005427 active site 196627005428 motif 2; other site 196627005429 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 196627005430 putative deacylase active site [active] 196627005431 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 196627005432 active site 196627005433 motif 3; other site 196627005434 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 196627005435 anticodon binding site; other site 196627005436 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3022 196627005437 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 196627005438 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 196627005439 metal ion-dependent adhesion site (MIDAS); other site 196627005440 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 196627005441 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196627005442 Walker A motif; other site 196627005443 ATP binding site [chemical binding]; other site 196627005444 Walker B motif; other site 196627005445 arginine finger; other site 196627005446 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 196627005447 active site 196627005448 SAM binding site [chemical binding]; other site 196627005449 homodimer interface [polypeptide binding]; other site 196627005450 Uncharacterized conserved protein [Function unknown]; Region: COG0397 196627005451 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 196627005452 dimer interface [polypeptide binding]; other site 196627005453 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 196627005454 dimer interface [polypeptide binding]; other site 196627005455 Predicted dehydrogenase [General function prediction only]; Region: COG0579 196627005456 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 196627005457 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 196627005458 Putative lysophospholipase; Region: Hydrolase_4; cl19140 196627005459 mycothione reductase; Region: mycothione_red; TIGR03452 196627005460 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 196627005461 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 196627005462 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 196627005463 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 196627005464 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 196627005465 active site 196627005466 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 196627005467 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 196627005468 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 196627005469 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 196627005470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196627005471 active site 196627005472 phosphorylation site [posttranslational modification] 196627005473 intermolecular recognition site; other site 196627005474 dimerization interface [polypeptide binding]; other site 196627005475 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 196627005476 DNA binding residues [nucleotide binding] 196627005477 dimerization interface [polypeptide binding]; other site 196627005478 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 196627005479 Histidine kinase; Region: HisKA_3; pfam07730 196627005480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196627005481 ATP binding site [chemical binding]; other site 196627005482 Mg2+ binding site [ion binding]; other site 196627005483 G-X-G motif; other site 196627005484 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 196627005485 FtsX-like permease family; Region: FtsX; pfam02687 196627005486 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 196627005487 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 196627005488 Walker A/P-loop; other site 196627005489 ATP binding site [chemical binding]; other site 196627005490 Q-loop/lid; other site 196627005491 ABC transporter signature motif; other site 196627005492 Walker B; other site 196627005493 D-loop; other site 196627005494 H-loop/switch region; other site 196627005495 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 196627005496 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 196627005497 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 196627005498 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 196627005499 active site 196627005500 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 196627005501 protein binding site [polypeptide binding]; other site 196627005502 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 196627005503 putative substrate binding region [chemical binding]; other site 196627005504 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 196627005505 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 196627005506 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 196627005507 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 196627005508 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 196627005509 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 196627005510 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 196627005511 Walker A/P-loop; other site 196627005512 ATP binding site [chemical binding]; other site 196627005513 Q-loop/lid; other site 196627005514 ABC transporter signature motif; other site 196627005515 Walker B; other site 196627005516 D-loop; other site 196627005517 H-loop/switch region; other site 196627005518 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 196627005519 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 196627005520 FeS/SAM binding site; other site 196627005521 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 196627005522 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 196627005523 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 196627005524 hinge region; other site 196627005525 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 196627005526 putative nucleotide binding site [chemical binding]; other site 196627005527 uridine monophosphate binding site [chemical binding]; other site 196627005528 homohexameric interface [polypeptide binding]; other site 196627005529 elongation factor Ts; Provisional; Region: tsf; PRK09377 196627005530 UBA/TS-N domain; Region: UBA; pfam00627 196627005531 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 196627005532 rRNA interaction site [nucleotide binding]; other site 196627005533 S8 interaction site; other site 196627005534 putative laminin-1 binding site; other site 196627005535 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 196627005536 Peptidase family M23; Region: Peptidase_M23; pfam01551 196627005537 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 196627005538 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 196627005539 active site 196627005540 DNA binding site [nucleotide binding] 196627005541 Int/Topo IB signature motif; other site 196627005542 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 196627005543 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 196627005544 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 196627005545 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 196627005546 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196627005547 Walker A motif; other site 196627005548 ATP binding site [chemical binding]; other site 196627005549 Walker B motif; other site 196627005550 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 196627005551 hypothetical protein; Reviewed; Region: PRK12497 196627005552 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 196627005553 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 196627005554 RNA/DNA hybrid binding site [nucleotide binding]; other site 196627005555 active site 196627005556 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 196627005557 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 196627005558 Catalytic site [active] 196627005559 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 196627005560 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 196627005561 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 196627005562 siderophore binding site; other site 196627005563 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 196627005564 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 196627005565 active site 196627005566 thiamine phosphate binding site [chemical binding]; other site 196627005567 pyrophosphate binding site [ion binding]; other site 196627005568 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 196627005569 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 196627005570 Sulfur transfer protein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ThiS; COG2104 196627005571 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 196627005572 ThiS interaction site; other site 196627005573 putative active site [active] 196627005574 tetramer interface [polypeptide binding]; other site 196627005575 thiamine biosynthesis protein ThiF; Validated; Region: PRK05600 196627005576 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 196627005577 ATP binding site [chemical binding]; other site 196627005578 substrate interface [chemical binding]; other site 196627005579 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: PspE; COG0607 196627005580 active site residue [active] 196627005581 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 196627005582 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 196627005583 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 196627005584 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 196627005585 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 196627005586 RNA binding site [nucleotide binding]; other site 196627005587 Transcriptional regulators [Transcription]; Region: PurR; COG1609 196627005588 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 196627005589 DNA binding site [nucleotide binding] 196627005590 domain linker motif; other site 196627005591 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 196627005592 dimerization interface [polypeptide binding]; other site 196627005593 ligand binding site [chemical binding]; other site 196627005594 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 196627005595 anion transporter; Region: dass; TIGR00785 196627005596 transmembrane helices; other site 196627005597 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 196627005598 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 196627005599 tetramer interface [polypeptide binding]; other site 196627005600 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 196627005601 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 196627005602 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 196627005603 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 196627005604 RimM N-terminal domain; Region: RimM; pfam01782 196627005605 PRC-barrel domain; Region: PRC; pfam05239 196627005606 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 196627005607 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14521 196627005608 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 196627005609 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 196627005610 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 196627005611 Acyltransferase family; Region: Acyl_transf_3; cl19154 196627005612 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 196627005613 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 196627005614 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196627005615 Walker A/P-loop; other site 196627005616 ATP binding site [chemical binding]; other site 196627005617 Q-loop/lid; other site 196627005618 ABC transporter signature motif; other site 196627005619 Walker B; other site 196627005620 D-loop; other site 196627005621 H-loop/switch region; other site 196627005622 signal recognition particle protein; Provisional; Region: PRK10867 196627005623 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 196627005624 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 196627005625 P loop; other site 196627005626 GTP binding site [chemical binding]; other site 196627005627 Signal peptide binding domain; Region: SRP_SPB; pfam02978 196627005628 PII uridylyl-transferase; Provisional; Region: glnD; PRK00227 196627005629 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 196627005630 metal binding triad; other site 196627005631 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 196627005632 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 196627005633 Zn2+ binding site [ion binding]; other site 196627005634 Mg2+ binding site [ion binding]; other site 196627005635 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 196627005636 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 196627005637 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 196627005638 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 196627005639 SRP54-type protein, GTPase domain; Region: SRP54; pfam00448 196627005640 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 196627005641 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 196627005642 Walker A/P-loop; other site 196627005643 ATP binding site [chemical binding]; other site 196627005644 Nucleoporin complex subunit 54; Region: Nup54; pfam13874 196627005645 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 196627005646 ABC transporter signature motif; other site 196627005647 Walker B; other site 196627005648 D-loop; other site 196627005649 H-loop/switch region; other site 196627005650 acylphosphatase; Provisional; Region: PRK14422 196627005651 Putative lysophospholipase; Region: Hydrolase_4; cl19140 196627005652 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 196627005653 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 196627005654 Transcriptional regulator [Transcription]; Region: LysR; COG0583 196627005655 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 196627005656 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 196627005657 dimerization interface [polypeptide binding]; other site 196627005658 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 196627005659 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4815 196627005660 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 196627005661 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 196627005662 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 196627005663 DNA binding site [nucleotide binding] 196627005664 catalytic residue [active] 196627005665 H2TH interface [polypeptide binding]; other site 196627005666 putative catalytic residues [active] 196627005667 turnover-facilitating residue; other site 196627005668 intercalation triad [nucleotide binding]; other site 196627005669 8OG recognition residue [nucleotide binding]; other site 196627005670 putative reading head residues; other site 196627005671 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 196627005672 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 196627005673 ribonuclease III; Reviewed; Region: rnc; PRK00102 196627005674 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 196627005675 dimerization interface [polypeptide binding]; other site 196627005676 active site 196627005677 metal binding site [ion binding]; metal-binding site 196627005678 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 196627005679 dsRNA binding site [nucleotide binding]; other site 196627005680 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 196627005681 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 196627005682 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 196627005683 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 196627005684 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 196627005685 Walker A/P-loop; other site 196627005686 ATP binding site [chemical binding]; other site 196627005687 Q-loop/lid; other site 196627005688 ABC transporter signature motif; other site 196627005689 Walker B; other site 196627005690 D-loop; other site 196627005691 H-loop/switch region; other site 196627005692 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 196627005693 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 196627005694 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 196627005695 ATP binding site [chemical binding]; other site 196627005696 Q-loop/lid; other site 196627005697 ABC transporter signature motif; other site 196627005698 Walker B; other site 196627005699 D-loop; other site 196627005700 H-loop/switch region; other site 196627005701 glutamate dehydrogenase; Provisional; Region: PRK09414 196627005702 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 196627005703 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 196627005704 NAD(P) binding site [chemical binding]; other site 196627005705 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 196627005706 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 196627005707 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 196627005708 nucleotide binding site/active site [active] 196627005709 HIT family signature motif; other site 196627005710 catalytic residue [active] 196627005711 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 196627005712 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 196627005713 metal binding site [ion binding]; metal-binding site 196627005714 putative dimer interface [polypeptide binding]; other site 196627005715 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 196627005716 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 196627005717 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 196627005718 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 196627005719 putative metal binding site [ion binding]; other site 196627005720 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 196627005721 active site 196627005722 pyruvate kinase; Provisional; Region: PRK06247 196627005723 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 196627005724 domain interfaces; other site 196627005725 active site 196627005726 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 196627005727 Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Region: TrpC; COG0134 196627005728 phosphate binding site [ion binding]; other site 196627005729 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 196627005730 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 196627005731 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 196627005732 substrate binding site [chemical binding]; other site 196627005733 glutamase interaction surface [polypeptide binding]; other site 196627005734 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 196627005735 active site 196627005736 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 196627005737 catalytic residues [active] 196627005738 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 196627005739 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 196627005740 putative active site [active] 196627005741 oxyanion strand; other site 196627005742 catalytic triad [active] 196627005743 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196627005744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627005745 putative substrate translocation pore; other site 196627005746 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 196627005747 putative active site pocket [active] 196627005748 4-fold oligomerization interface [polypeptide binding]; other site 196627005749 metal binding residues [ion binding]; metal-binding site 196627005750 3-fold/trimer interface [polypeptide binding]; other site 196627005751 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 196627005752 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 196627005753 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196627005754 homodimer interface [polypeptide binding]; other site 196627005755 catalytic residue [active] 196627005756 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 196627005757 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 196627005758 NAD binding site [chemical binding]; other site 196627005759 dimerization interface [polypeptide binding]; other site 196627005760 product binding site; other site 196627005761 substrate binding site [chemical binding]; other site 196627005762 zinc binding site [ion binding]; other site 196627005763 catalytic residues [active] 196627005764 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 196627005765 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 196627005766 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 196627005767 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 196627005768 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 196627005769 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 196627005770 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 196627005771 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 196627005772 active site 196627005773 catalytic site [active] 196627005774 Methyltransferase domain; Region: Methyltransf_31; pfam13847 196627005775 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196627005776 S-adenosylmethionine binding site [chemical binding]; other site 196627005777 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 196627005778 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 196627005779 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 196627005780 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 196627005781 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 196627005782 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 196627005783 Transcriptional regulators [Transcription]; Region: PurR; COG1609 196627005784 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 196627005785 DNA binding site [nucleotide binding] 196627005786 domain linker motif; other site 196627005787 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 196627005788 dimerization interface [polypeptide binding]; other site 196627005789 ligand binding site [chemical binding]; other site 196627005790 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 196627005791 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 196627005792 Walker A/P-loop; other site 196627005793 ATP binding site [chemical binding]; other site 196627005794 Q-loop/lid; other site 196627005795 ABC transporter signature motif; other site 196627005796 Walker B; other site 196627005797 D-loop; other site 196627005798 H-loop/switch region; other site 196627005799 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 196627005800 ABC-ATPase subunit interface; other site 196627005801 dimer interface [polypeptide binding]; other site 196627005802 putative PBP binding regions; other site 196627005803 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 196627005804 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 196627005805 putative binding site residues; other site 196627005806 ABC transporter periplasmic component; ABC-type cobalamin/Fe3+-siderophores transport systems 196627005807 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 196627005808 dimerization interface [polypeptide binding]; other site 196627005809 putative DNA binding site [nucleotide binding]; other site 196627005810 Transcriptional regulators [Transcription]; Region: MarR; COG1846 196627005811 putative Zn2+ binding site [ion binding]; other site 196627005812 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 196627005813 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 196627005814 active site 196627005815 catalytic site [active] 196627005816 substrate binding site [chemical binding]; other site 196627005817 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 196627005818 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 196627005819 active site 196627005820 catalytic site [active] 196627005821 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 196627005822 synthetase active site [active] 196627005823 NTP binding site [chemical binding]; other site 196627005824 metal binding site [ion binding]; metal-binding site 196627005825 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 196627005826 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 196627005827 RNA binding surface [nucleotide binding]; other site 196627005828 Uncharacterized conserved protein [Function unknown]; Region: COG1739 196627005829 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 196627005830 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 196627005831 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 196627005832 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 196627005833 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 196627005834 catalytic site [active] 196627005835 active site 196627005836 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 196627005837 threonine dehydratase; Validated; Region: PRK08639 196627005838 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 196627005839 tetramer interface [polypeptide binding]; other site 196627005840 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196627005841 catalytic residue [active] 196627005842 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 196627005843 putative Ile/Val binding site [chemical binding]; other site 196627005844 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 196627005845 substrate binding site [chemical binding]; other site 196627005846 THF binding site; other site 196627005847 zinc-binding site [ion binding]; other site 196627005848 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 196627005849 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 196627005850 active site 196627005851 PHP Thumb interface [polypeptide binding]; other site 196627005852 metal binding site [ion binding]; metal-binding site 196627005853 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 196627005854 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 196627005855 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 196627005856 generic binding surface II; other site 196627005857 generic binding surface I; other site 196627005858 Predicted permeases [General function prediction only]; Region: RarD; COG2962 196627005859 EamA-like transporter family; Region: EamA; cl17759 196627005860 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 196627005861 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 196627005862 oxidoreductase; Provisional; Region: PRK06128 196627005863 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196627005864 NAD(P) binding site [chemical binding]; other site 196627005865 active site 196627005866 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 196627005867 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842 196627005868 dimer interface [polypeptide binding]; other site 196627005869 active site 196627005870 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 196627005871 catalytic residues [active] 196627005872 substrate binding site [chemical binding]; other site 196627005873 cysteine synthase; Region: PLN02565 196627005874 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 196627005875 dimer interface [polypeptide binding]; other site 196627005876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196627005877 catalytic residue [active] 196627005878 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 196627005879 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 196627005880 RNA binding surface [nucleotide binding]; other site 196627005881 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 196627005882 active site 196627005883 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 196627005884 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 196627005885 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 196627005886 ABC transporter; Region: ABC_tran_2; pfam12848 196627005887 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 196627005888 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 196627005889 active site 196627005890 homotetramer interface [polypeptide binding]; other site 196627005891 homodimer interface [polypeptide binding]; other site 196627005892 DNA polymerase IV; Provisional; Region: PRK03348 196627005893 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 196627005894 active site 196627005895 DNA binding site [nucleotide binding] 196627005896 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 196627005897 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 196627005898 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 196627005899 DNA binding residues [nucleotide binding] 196627005900 HEAT repeats; Region: HEAT_2; pfam13646 196627005901 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 196627005902 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 196627005903 active site 196627005904 HIGH motif; other site 196627005905 nucleotide binding site [chemical binding]; other site 196627005906 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 196627005907 active site 196627005908 KMSKS motif; other site 196627005909 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 196627005910 tRNA binding surface [nucleotide binding]; other site 196627005911 anticodon binding site; other site 196627005912 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 196627005913 DivIVA domain; Region: DivI1A_domain; TIGR03544 196627005914 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 196627005915 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 196627005916 Predicted integral membrane protein [Function unknown]; Region: COG0762 196627005917 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 196627005918 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 196627005919 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 196627005920 catalytic residue [active] 196627005921 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 196627005922 cell division protein FtsZ; Validated; Region: PRK09330 196627005923 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 196627005924 nucleotide binding site [chemical binding]; other site 196627005925 SulA interaction site; other site 196627005926 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 196627005927 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 196627005928 Cell division protein FtsQ; Region: FtsQ; pfam03799 196627005929 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 196627005930 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 196627005931 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 196627005932 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 196627005933 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 196627005934 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 196627005935 active site 196627005936 homodimer interface [polypeptide binding]; other site 196627005937 cell division protein FtsW; Region: ftsW; TIGR02614 196627005938 Pre-mRNA-splicing factor 38-associated hydrophilic C-term; Region: PRP38_assoc; pfam12871 196627005939 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141 196627005940 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 196627005941 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 196627005942 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 196627005943 Mg++ binding site [ion binding]; other site 196627005944 putative catalytic motif [active] 196627005945 putative substrate binding site [chemical binding]; other site 196627005946 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 196627005947 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 196627005948 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 196627005949 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 196627005950 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 196627005951 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 196627005952 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 196627005953 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 196627005954 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 196627005955 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 196627005956 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 196627005957 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 196627005958 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 196627005959 MraZ protein; Region: MraZ; pfam02381 196627005960 MraZ protein; Region: MraZ; pfam02381 196627005961 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 196627005962 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 196627005963 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196627005964 Coenzyme A binding pocket [chemical binding]; other site 196627005965 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 196627005966 FAD binding site [chemical binding]; other site 196627005967 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 196627005968 substrate binding pocket [chemical binding]; other site 196627005969 chain length determination region; other site 196627005970 substrate-Mg2+ binding site; other site 196627005971 catalytic residues [active] 196627005972 aspartate-rich region 1; other site 196627005973 active site lid residues [active] 196627005974 aspartate-rich region 2; other site 196627005975 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 196627005976 Helix-turn-helix domain; Region: HTH_17; pfam12728 196627005977 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 196627005978 Catalytic domain of Protein Kinases; Region: PKc; cd00180 196627005979 active site 196627005980 ATP binding site [chemical binding]; other site 196627005981 substrate binding site [chemical binding]; other site 196627005982 activation loop (A-loop); other site 196627005983 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 196627005984 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 196627005985 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 196627005986 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 196627005987 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 196627005988 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 196627005989 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 196627005990 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 196627005991 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200 196627005992 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 196627005993 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 196627005994 Predicted esterase [General function prediction only]; Region: COG0627 196627005995 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 196627005996 Predicted membrane protein [Function unknown]; Region: COG4763 196627005997 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 196627005998 putative acyl-acceptor binding pocket; other site 196627005999 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 196627006000 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 196627006001 nucleotide binding site [chemical binding]; other site 196627006002 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 196627006003 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 196627006004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 196627006005 Spectrin repeats; Region: SPEC; smart00150 196627006006 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 196627006007 NlpC/P60 family; Region: NLPC_P60; pfam00877 196627006008 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 196627006009 NlpC/P60 family; Region: NLPC_P60; pfam00877 196627006010 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 196627006011 heme bH binding site [chemical binding]; other site 196627006012 Qi binding site; other site 196627006013 intrachain domain interface; other site 196627006014 heme bL binding site [chemical binding]; other site 196627006015 interchain domain interface [polypeptide binding]; other site 196627006016 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 196627006017 Qo binding site; other site 196627006018 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 196627006019 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 196627006020 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 196627006021 iron-sulfur cluster [ion binding]; other site 196627006022 [2Fe-2S] cluster binding site [ion binding]; other site 196627006023 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 196627006024 Cytochrome c; Region: Cytochrom_C; pfam00034 196627006025 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 196627006026 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 196627006027 Subunit I/III interface [polypeptide binding]; other site 196627006028 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 196627006029 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 196627006030 Cupredoxin superfamily; Region: Cupredoxin; cl19115 196627006031 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 196627006032 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 196627006033 active site 196627006034 dimer interface [polypeptide binding]; other site 196627006035 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 196627006036 Ligand Binding Site [chemical binding]; other site 196627006037 Molecular Tunnel; other site 196627006038 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 196627006039 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 196627006040 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 196627006041 homotrimer interface [polypeptide binding]; other site 196627006042 Walker A motif; other site 196627006043 GTP binding site [chemical binding]; other site 196627006044 Walker B motif; other site 196627006045 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 196627006046 putative dimer interface [polypeptide binding]; other site 196627006047 active site pocket [active] 196627006048 putative cataytic base [active] 196627006049 cobalamin synthase; Reviewed; Region: cobS; PRK00235 196627006050 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 196627006051 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196627006052 NAD(P) binding site [chemical binding]; other site 196627006053 active site 196627006054 Branched-chain amino acid aminotransferase; Region: DUF3665; pfam12427 196627006055 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 196627006056 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 196627006057 homodimer interface [polypeptide binding]; other site 196627006058 substrate-cofactor binding pocket; other site 196627006059 catalytic residue [active] 196627006060 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 196627006061 multifunctional aminopeptidase A; Provisional; Region: PRK00913 196627006062 interface (dimer of trimers) [polypeptide binding]; other site 196627006063 Substrate-binding/catalytic site; other site 196627006064 Zn-binding sites [ion binding]; other site 196627006065 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 196627006066 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 196627006067 E3 interaction surface; other site 196627006068 lipoyl attachment site [posttranslational modification]; other site 196627006069 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 196627006070 E3 interaction surface; other site 196627006071 lipoyl attachment site [posttranslational modification]; other site 196627006072 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 196627006073 E3 interaction surface; other site 196627006074 lipoyl attachment site [posttranslational modification]; other site 196627006075 e3 binding domain; Region: E3_binding; pfam02817 196627006076 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 196627006077 lipoate-protein ligase B; Provisional; Region: PRK14345 196627006078 lipoyl synthase; Provisional; Region: PRK05481 196627006079 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 196627006080 FeS/SAM binding site; other site 196627006081 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 196627006082 Predicted permease [General function prediction only]; Region: COG2985 196627006083 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 196627006084 TrkA-C domain; Region: TrkA_C; pfam02080 196627006085 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 196627006086 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 196627006087 Helix-turn-helix domain; Region: HTH_38; pfam13936 196627006088 Homeodomain-like domain; Region: HTH_32; pfam13565 196627006089 Integrase core domain; Region: rve; pfam00665 196627006090 RDD family; Region: RDD; pfam06271 196627006091 glutamine synthetase, type I; Region: GlnA; TIGR00653 196627006092 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 196627006093 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 196627006094 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 196627006095 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 196627006096 nudix motif; other site 196627006097 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 196627006098 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 196627006099 homotrimer interaction site [polypeptide binding]; other site 196627006100 putative active site [active] 196627006101 threonine synthase; Validated; Region: PRK09225 196627006102 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 196627006103 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196627006104 catalytic residue [active] 196627006105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627006106 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196627006107 putative substrate translocation pore; other site 196627006108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627006109 putative substrate translocation pore; other site 196627006110 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 196627006111 heme binding pocket [chemical binding]; other site 196627006112 heme ligand [chemical binding]; other site 196627006113 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 196627006114 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 196627006115 metal binding triad; other site 196627006116 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 196627006117 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 196627006118 metal binding triad; other site 196627006119 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; cl19627 196627006120 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 196627006121 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 196627006122 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 196627006123 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 196627006124 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 196627006125 putative active site; other site 196627006126 putative metal binding residues [ion binding]; other site 196627006127 signature motif; other site 196627006128 putative triphosphate binding site [ion binding]; other site 196627006129 CHAD domain; Region: CHAD; pfam05235 196627006130 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 196627006131 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 196627006132 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 196627006133 Exoribonuclease R [Transcription]; Region: VacB; COG0557 196627006134 RNB domain; Region: RNB; pfam00773 196627006135 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 196627006136 RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI; Region: RNase_HI_like; cd09279 196627006137 RNA/DNA hybrid binding site [nucleotide binding]; other site 196627006138 active site 196627006139 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 196627006140 catalytic core [active] 196627006141 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 196627006142 Putative zinc ribbon domain; Region: DUF164; pfam02591 196627006143 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 196627006144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 196627006145 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 196627006146 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196627006147 active site 196627006148 motif I; other site 196627006149 motif II; other site 196627006150 Low molecular weight phosphatase family; Region: LMWPc; cd00115 196627006151 active site 196627006152 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 196627006153 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 196627006154 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 196627006155 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 196627006156 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 196627006157 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 196627006158 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 196627006159 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 196627006160 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 196627006161 dimer interface [polypeptide binding]; other site 196627006162 TPP-binding site [chemical binding]; other site 196627006163 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 196627006164 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 196627006165 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196627006166 Walker A/P-loop; other site 196627006167 ATP binding site [chemical binding]; other site 196627006168 Q-loop/lid; other site 196627006169 ABC transporter signature motif; other site 196627006170 Walker B; other site 196627006171 D-loop; other site 196627006172 H-loop/switch region; other site 196627006173 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 196627006174 TM-ABC transporter signature motif; other site 196627006175 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 196627006176 zinc binding site [ion binding]; other site 196627006177 putative ligand binding site [chemical binding]; other site 196627006178 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 196627006179 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 196627006180 Putative lysophospholipase; Region: Hydrolase_4; cl19140 196627006181 Putative lysophospholipase; Region: Hydrolase_4; cl19140 196627006182 acyl carrier protein; Provisional; Region: acpP; PRK00982 196627006183 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 196627006184 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196627006185 active site 196627006186 motif I; other site 196627006187 motif II; other site 196627006188 Uncharacterized conserved protein [Function unknown]; Region: COG4850 196627006189 Beta-lactamase; Region: Beta-lactamase; pfam00144 196627006190 Domain of unknown function (DUF4274); Region: DUF4274; pfam14096 196627006191 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 196627006192 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 196627006193 putative active site [active] 196627006194 putative metal binding site [ion binding]; other site 196627006195 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 196627006196 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 196627006197 DNA primase; Validated; Region: dnaG; PRK05667 196627006198 CHC2 zinc finger; Region: zf-CHC2; cl17510 196627006199 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 196627006200 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 196627006201 active site 196627006202 metal binding site [ion binding]; metal-binding site 196627006203 interdomain interaction site; other site 196627006204 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 196627006205 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 196627006206 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 196627006207 active site 196627006208 barstar interaction site; other site 196627006209 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 196627006210 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 196627006211 glutaminase active site [active] 196627006212 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 196627006213 dimer interface [polypeptide binding]; other site 196627006214 active site 196627006215 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 196627006216 dimer interface [polypeptide binding]; other site 196627006217 active site 196627006218 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 196627006219 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 196627006220 Zn2+ binding site [ion binding]; other site 196627006221 Mg2+ binding site [ion binding]; other site 196627006222 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 196627006223 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 196627006224 putative active site [active] 196627006225 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase; Region: TPM; pfam04536 196627006226 glycyl-tRNA synthetase; Provisional; Region: PRK04173 196627006227 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 196627006228 dimer interface [polypeptide binding]; other site 196627006229 motif 1; other site 196627006230 active site 196627006231 motif 2; other site 196627006232 motif 3; other site 196627006233 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 196627006234 anticodon binding site; other site 196627006235 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 196627006236 dimerization interface [polypeptide binding]; other site 196627006237 putative DNA binding site [nucleotide binding]; other site 196627006238 putative Zn2+ binding site [ion binding]; other site 196627006239 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 196627006240 metal binding site 2 [ion binding]; metal-binding site 196627006241 putative DNA binding helix; other site 196627006242 metal binding site 1 [ion binding]; metal-binding site 196627006243 dimer interface [polypeptide binding]; other site 196627006244 structural Zn2+ binding site [ion binding]; other site 196627006245 Domain of unknown function (DUF222); Region: DUF222; pfam02720 196627006246 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 196627006247 active site 196627006248 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 196627006249 diiron binding motif [ion binding]; other site 196627006250 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 196627006251 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 196627006252 active site 196627006253 dimer interface [polypeptide binding]; other site 196627006254 Recombination protein O N terminal; Region: RecO_N; pfam11967 196627006255 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 196627006256 Recombination protein O C terminal; Region: RecO_C; pfam02565 196627006257 GTPase Era; Reviewed; Region: era; PRK00089 196627006258 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 196627006259 G1 box; other site 196627006260 GTP/Mg2+ binding site [chemical binding]; other site 196627006261 Switch I region; other site 196627006262 G2 box; other site 196627006263 Switch II region; other site 196627006264 G3 box; other site 196627006265 G4 box; other site 196627006266 G5 box; other site 196627006267 KH domain; Region: KH_2; pfam07650 196627006268 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 196627006269 Domain of unknown function DUF21; Region: DUF21; pfam01595 196627006270 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 196627006271 Transporter associated domain; Region: CorC_HlyC; smart01091 196627006272 metal-binding heat shock protein; Provisional; Region: PRK00016 196627006273 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 196627006274 PhoH-like protein; Region: PhoH; pfam02562 196627006275 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 196627006276 chaperone protein DnaJ; Provisional; Region: PRK14278 196627006277 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 196627006278 HSP70 interaction site [polypeptide binding]; other site 196627006279 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 196627006280 substrate binding site [polypeptide binding]; other site 196627006281 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 196627006282 Zn binding sites [ion binding]; other site 196627006283 dimer interface [polypeptide binding]; other site 196627006284 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 196627006285 HrcA protein C terminal domain; Region: HrcA; pfam01628 196627006286 coproporphyrinogen III oxidase; Validated; Region: PRK05628 196627006287 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 196627006288 FeS/SAM binding site; other site 196627006289 HemN C-terminal domain; Region: HemN_C; pfam06969 196627006290 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 196627006291 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 196627006292 acyl-activating enzyme (AAE) consensus motif; other site 196627006293 putative AMP binding site [chemical binding]; other site 196627006294 putative active site [active] 196627006295 putative CoA binding site [chemical binding]; other site 196627006296 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 196627006297 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 196627006298 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 196627006299 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 196627006300 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196627006301 Walker A/P-loop; other site 196627006302 ATP binding site [chemical binding]; other site 196627006303 Q-loop/lid; other site 196627006304 ABC transporter signature motif; other site 196627006305 Walker B; other site 196627006306 D-loop; other site 196627006307 H-loop/switch region; other site 196627006308 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 196627006309 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 196627006310 active site 196627006311 Zn binding site [ion binding]; other site 196627006312 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 196627006313 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 196627006314 substrate binding pocket [chemical binding]; other site 196627006315 catalytic triad [active] 196627006316 trehalose synthase; Region: treS_nterm; TIGR02456 196627006317 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 196627006318 active site 196627006319 catalytic site [active] 196627006320 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 196627006321 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 196627006322 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 196627006323 active site 196627006324 metal binding site [ion binding]; metal-binding site 196627006325 nudix motif; other site 196627006326 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 196627006327 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 196627006328 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 196627006329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196627006330 homodimer interface [polypeptide binding]; other site 196627006331 catalytic residue [active] 196627006332 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 196627006333 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 196627006334 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 196627006335 Predicted permeases [General function prediction only]; Region: COG0679 196627006336 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 196627006337 FAD binding domain; Region: FAD_binding_4; pfam01565 196627006338 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 196627006339 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 196627006340 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 196627006341 Transcriptional regulators [Transcription]; Region: GntR; COG1802 196627006342 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 196627006343 DNA-binding site [nucleotide binding]; DNA binding site 196627006344 FCD domain; Region: FCD; pfam07729 196627006345 DctM-like transporters; Region: DctM; pfam06808 196627006346 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 196627006347 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 196627006348 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 196627006349 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 196627006350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196627006351 dimer interface [polypeptide binding]; other site 196627006352 conserved gate region; other site 196627006353 putative PBP binding loops; other site 196627006354 ABC-ATPase subunit interface; other site 196627006355 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 196627006356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196627006357 dimer interface [polypeptide binding]; other site 196627006358 conserved gate region; other site 196627006359 putative PBP binding loops; other site 196627006360 ABC-ATPase subunit interface; other site 196627006361 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 196627006362 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 196627006363 Walker A/P-loop; other site 196627006364 ATP binding site [chemical binding]; other site 196627006365 Q-loop/lid; other site 196627006366 ABC transporter signature motif; other site 196627006367 Walker B; other site 196627006368 D-loop; other site 196627006369 H-loop/switch region; other site 196627006370 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 196627006371 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 196627006372 Walker A/P-loop; other site 196627006373 ATP binding site [chemical binding]; other site 196627006374 Q-loop/lid; other site 196627006375 ABC transporter signature motif; other site 196627006376 Walker B; other site 196627006377 D-loop; other site 196627006378 H-loop/switch region; other site 196627006379 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 196627006380 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 196627006381 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 196627006382 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 196627006383 substrate binding site [chemical binding]; other site 196627006384 dimer interface [polypeptide binding]; other site 196627006385 ATP binding site [chemical binding]; other site 196627006386 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 196627006387 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 196627006388 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 196627006389 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 196627006390 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 196627006391 active site 196627006392 phosphate binding residues; other site 196627006393 catalytic residues [active] 196627006394 malate synthase G; Provisional; Region: PRK02999 196627006395 active site 196627006396 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 196627006397 tetramer interface [polypeptide binding]; other site 196627006398 active site 196627006399 Mg2+/Mn2+ binding site [ion binding]; other site 196627006400 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 196627006401 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 196627006402 putative active site [active] 196627006403 putative metal binding site [ion binding]; other site 196627006404 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 196627006405 Lamin Tail Domain; Region: LTD; pfam00932 196627006406 DctM-like transporters; Region: DctM; pfam06808 196627006407 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 196627006408 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 196627006409 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 196627006410 GTP-binding protein LepA; Provisional; Region: PRK05433 196627006411 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 196627006412 G1 box; other site 196627006413 putative GEF interaction site [polypeptide binding]; other site 196627006414 GTP/Mg2+ binding site [chemical binding]; other site 196627006415 Switch I region; other site 196627006416 G2 box; other site 196627006417 G3 box; other site 196627006418 Switch II region; other site 196627006419 G4 box; other site 196627006420 G5 box; other site 196627006421 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 196627006422 Elongation Factor G, domain II; Region: EFG_II; pfam14492 196627006423 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 196627006424 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 196627006425 PemK-like protein; Region: PemK; cl00995 196627006426 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 196627006427 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 196627006428 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 196627006429 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 196627006430 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 196627006431 hypothetical protein; Validated; Region: PRK05629 196627006432 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; cl19912 196627006433 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 196627006434 Competence protein; Region: Competence; pfam03772 196627006435 SLBB domain; Region: SLBB; pfam10531 196627006436 comEA protein; Region: comE; TIGR01259 196627006437 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 196627006438 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 196627006439 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 196627006440 catalytic core [active] 196627006441 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 196627006442 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 196627006443 active site 196627006444 (T/H)XGH motif; other site 196627006445 Cutinase; Region: Cutinase; pfam01083 196627006446 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 196627006447 putative catalytic cysteine [active] 196627006448 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 196627006449 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 196627006450 putative ligand binding site [chemical binding]; other site 196627006451 putative NAD binding site [chemical binding]; other site 196627006452 catalytic site [active] 196627006453 glutamate 5-kinase; Region: proB; TIGR01027 196627006454 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 196627006455 nucleotide binding site [chemical binding]; other site 196627006456 homotetrameric interface [polypeptide binding]; other site 196627006457 putative phosphate binding site [ion binding]; other site 196627006458 putative allosteric binding site; other site 196627006459 PUA domain; Region: PUA; pfam01472 196627006460 GTPase CgtA; Reviewed; Region: obgE; PRK12296 196627006461 GTP1/OBG; Region: GTP1_OBG; pfam01018 196627006462 Obg GTPase; Region: Obg; cd01898 196627006463 G1 box; other site 196627006464 GTP/Mg2+ binding site [chemical binding]; other site 196627006465 Switch I region; other site 196627006466 G2 box; other site 196627006467 G3 box; other site 196627006468 Switch II region; other site 196627006469 G4 box; other site 196627006470 G5 box; other site 196627006471 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 196627006472 Sulfate transporter family; Region: Sulfate_transp; cl19250 196627006473 xanthine permease; Region: pbuX; TIGR03173 196627006474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 196627006475 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 196627006476 active site 196627006477 catalytic tetrad [active] 196627006478 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 196627006479 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 196627006480 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 196627006481 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 196627006482 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 196627006483 homodimer interface [polypeptide binding]; other site 196627006484 oligonucleotide binding site [chemical binding]; other site 196627006485 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 196627006486 Predicted transcriptional regulator [Transcription]; Region: COG4190 196627006487 Pirin-related protein [General function prediction only]; Region: COG1741 196627006488 Pirin; Region: Pirin; pfam02678 196627006489 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 196627006490 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 196627006491 Transposase; Region: DDE_Tnp_ISL3; pfam01610 196627006492 Pirin-related protein [General function prediction only]; Region: COG1741 196627006493 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 196627006494 Uncharacterized conserved protein [Function unknown]; Region: COG2128 196627006495 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 196627006496 Nucleoside diphosphate kinase; Region: NDK; pfam00334 196627006497 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 196627006498 active site 196627006499 multimer interface [polypeptide binding]; other site 196627006500 Predicted acetyltransferase [General function prediction only]; Region: COG2388 196627006501 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 196627006502 hydrophobic ligand binding site; other site 196627006503 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 196627006504 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 196627006505 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 196627006506 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 196627006507 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 196627006508 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 196627006509 active site 196627006510 HIGH motif; other site 196627006511 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 196627006512 KMSKS motif; other site 196627006513 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 196627006514 tRNA binding surface [nucleotide binding]; other site 196627006515 anticodon binding site; other site 196627006516 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 196627006517 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 196627006518 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 196627006519 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 196627006520 cell shape determining protein, MreB/Mrl family; Region: mreB; TIGR00904 196627006521 nucleotide binding site [chemical binding]; other site 196627006522 putative NEF/HSP70 interaction site [polypeptide binding]; other site 196627006523 SBD interface [polypeptide binding]; other site 196627006524 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 196627006525 malate dehydrogenase; Provisional; Region: PRK05442 196627006526 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 196627006527 NAD(P) binding site [chemical binding]; other site 196627006528 dimer interface [polypeptide binding]; other site 196627006529 malate binding site [chemical binding]; other site 196627006530 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 196627006531 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 196627006532 Predicted transcriptional regulators [Transcription]; Region: COG1695 196627006533 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 196627006534 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 196627006535 iron-sulfur cluster [ion binding]; other site 196627006536 [2Fe-2S] cluster binding site [ion binding]; other site 196627006537 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 196627006538 alpha subunit interface [polypeptide binding]; other site 196627006539 active site 196627006540 substrate binding site [chemical binding]; other site 196627006541 Fe binding site [ion binding]; other site 196627006542 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 196627006543 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 196627006544 FMN-binding pocket [chemical binding]; other site 196627006545 flavin binding motif; other site 196627006546 phosphate binding motif [ion binding]; other site 196627006547 beta-alpha-beta structure motif; other site 196627006548 NAD binding pocket [chemical binding]; other site 196627006549 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 196627006550 catalytic loop [active] 196627006551 iron binding site [ion binding]; other site 196627006552 benzoate transport; Region: 2A0115; TIGR00895 196627006553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627006554 putative substrate translocation pore; other site 196627006555 Predicted permeases [General function prediction only]; Region: COG0679 196627006556 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 196627006557 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 196627006558 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 196627006559 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196627006560 Walker A motif; other site 196627006561 ATP binding site [chemical binding]; other site 196627006562 Walker B motif; other site 196627006563 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 196627006564 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844 196627006565 active site 196627006566 catalytic triad [active] 196627006567 oxyanion hole [active] 196627006568 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 196627006569 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 196627006570 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 196627006571 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 196627006572 Bacterial transcriptional regulator; Region: IclR; pfam01614 196627006573 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 196627006574 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 196627006575 dimer interface [polypeptide binding]; other site 196627006576 active site 196627006577 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 196627006578 Putative lysophospholipase; Region: Hydrolase_4; cl19140 196627006579 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 196627006580 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 196627006581 DNA binding residues [nucleotide binding] 196627006582 dimerization interface [polypeptide binding]; other site 196627006583 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 196627006584 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 196627006585 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 196627006586 tetramer interface [polypeptide binding]; other site 196627006587 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 196627006588 protocatechuate 3,4-dioxygenase, alpha subunit; Region: protocat_alph; TIGR02423 196627006589 active site 196627006590 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 196627006591 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 196627006592 active site 196627006593 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 196627006594 active site 196627006595 Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829 196627006596 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 196627006597 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 196627006598 octamer interface [polypeptide binding]; other site 196627006599 active site 196627006600 catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438 196627006601 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 196627006602 active site 196627006603 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 196627006604 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 196627006605 iron-sulfur cluster [ion binding]; other site 196627006606 [2Fe-2S] cluster binding site [ion binding]; other site 196627006607 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 196627006608 putative alpha subunit interface [polypeptide binding]; other site 196627006609 putative active site [active] 196627006610 putative substrate binding site [chemical binding]; other site 196627006611 Fe binding site [ion binding]; other site 196627006612 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 196627006613 inter-subunit interface; other site 196627006614 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 196627006615 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 196627006616 catalytic loop [active] 196627006617 iron binding site [ion binding]; other site 196627006618 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 196627006619 FAD binding pocket [chemical binding]; other site 196627006620 FAD binding motif [chemical binding]; other site 196627006621 phosphate binding motif [ion binding]; other site 196627006622 beta-alpha-beta structure motif; other site 196627006623 NAD binding pocket [chemical binding]; other site 196627006624 Transcriptional regulators [Transcription]; Region: FadR; COG2186 196627006625 FCD domain; Region: FCD; pfam07729 196627006626 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 196627006627 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196627006628 NAD(P) binding site [chemical binding]; other site 196627006629 active site 196627006630 AAA domain; Region: AAA_22; pfam13401 196627006631 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 196627006632 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 196627006633 DNA binding residues [nucleotide binding] 196627006634 dimerization interface [polypeptide binding]; other site 196627006635 benzoate transport; Region: 2A0115; TIGR00895 196627006636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627006637 putative substrate translocation pore; other site 196627006638 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 196627006639 Sulfate transporter family; Region: Sulfate_transp; cl19250 196627006640 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 196627006641 oligomer interface [polypeptide binding]; other site 196627006642 active site residues [active] 196627006643 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 196627006644 oligomer interface [polypeptide binding]; other site 196627006645 active site residues [active] 196627006646 trigger factor; Provisional; Region: tig; PRK01490 196627006647 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 196627006648 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 196627006649 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 196627006650 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 196627006651 dimerization interface [polypeptide binding]; other site 196627006652 putative DNA binding site [nucleotide binding]; other site 196627006653 putative Zn2+ binding site [ion binding]; other site 196627006654 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 196627006655 RDD family; Region: RDD; pfam06271 196627006656 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 196627006657 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 196627006658 Predicted membrane protein [Function unknown]; Region: COG2311 196627006659 Protein of unknown function (DUF418); Region: DUF418; pfam04235 196627006660 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 196627006661 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 196627006662 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 196627006663 Zn binding site [ion binding]; other site 196627006664 ERAP1-like C-terminal domain; Region: ERAP1_C; pfam11838 196627006665 Uncharacterized conserved protein [Function unknown]; Region: COG4748 196627006666 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 196627006667 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 196627006668 active site lid residues [active] 196627006669 substrate binding pocket [chemical binding]; other site 196627006670 catalytic residues [active] 196627006671 substrate-Mg2+ binding site; other site 196627006672 aspartate-rich region 1; other site 196627006673 aspartate-rich region 2; other site 196627006674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627006675 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196627006676 putative substrate translocation pore; other site 196627006677 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 196627006678 alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030 196627006679 Uncharacterized conserved protein [Function unknown]; Region: COG2128 196627006680 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 196627006681 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 196627006682 Walker A/P-loop; other site 196627006683 ATP binding site [chemical binding]; other site 196627006684 Q-loop/lid; other site 196627006685 ABC transporter signature motif; other site 196627006686 Walker B; other site 196627006687 D-loop; other site 196627006688 H-loop/switch region; other site 196627006689 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 196627006690 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 196627006691 Walker A/P-loop; other site 196627006692 ATP binding site [chemical binding]; other site 196627006693 Q-loop/lid; other site 196627006694 ABC transporter signature motif; other site 196627006695 Walker B; other site 196627006696 D-loop; other site 196627006697 H-loop/switch region; other site 196627006698 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 196627006699 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 196627006700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196627006701 dimer interface [polypeptide binding]; other site 196627006702 conserved gate region; other site 196627006703 putative PBP binding loops; other site 196627006704 ABC-ATPase subunit interface; other site 196627006705 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 196627006706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196627006707 dimer interface [polypeptide binding]; other site 196627006708 conserved gate region; other site 196627006709 putative PBP binding loops; other site 196627006710 ABC-ATPase subunit interface; other site 196627006711 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 196627006712 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 196627006713 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 196627006714 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 196627006715 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 196627006716 inhibitor-cofactor binding pocket; inhibition site 196627006717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196627006718 catalytic residue [active] 196627006719 Domain of unknown function (DUF222); Region: DUF222; pfam02720 196627006720 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 196627006721 active site 196627006722 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 196627006723 short chain dehydrogenase; Provisional; Region: PRK08219 196627006724 HetN oxidoreductase-like, classical (c) SDR; Region: HetN_like_SDR_c; cd08932 196627006725 putative NAD(P) binding site [chemical binding]; other site 196627006726 active site 196627006727 tetracycline repressor protein TetR; Provisional; Region: PRK13756 196627006728 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 196627006729 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 196627006730 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 196627006731 homodimer interface [polypeptide binding]; other site 196627006732 substrate-cofactor binding pocket; other site 196627006733 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196627006734 catalytic residue [active] 196627006735 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 196627006736 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196627006737 Walker A/P-loop; other site 196627006738 ATP binding site [chemical binding]; other site 196627006739 Q-loop/lid; other site 196627006740 ABC transporter signature motif; other site 196627006741 Walker B; other site 196627006742 D-loop; other site 196627006743 H-loop/switch region; other site 196627006744 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 196627006745 apolar tunnel; other site 196627006746 heme binding site [chemical binding]; other site 196627006747 dimerization interface [polypeptide binding]; other site 196627006748 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 196627006749 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 196627006750 Chromate transporter; Region: Chromate_transp; pfam02417 196627006751 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 196627006752 active site 196627006753 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 196627006754 Sulfatase; Region: Sulfatase; cl19157 196627006755 Sulfatase; Region: Sulfatase; cl19157 196627006756 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 196627006757 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 196627006758 ABC transporter; Region: ABC_tran_2; pfam12848 196627006759 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 196627006760 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 196627006761 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 196627006762 dimer interface [polypeptide binding]; other site 196627006763 ssDNA binding site [nucleotide binding]; other site 196627006764 tetramer (dimer of dimers) interface [polypeptide binding]; other site 196627006765 Copper resistance protein D; Region: CopD; cl00563 196627006766 Predicted membrane protein [Function unknown]; Region: COG3336 196627006767 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 196627006768 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl19058 196627006769 active site 196627006770 dimer interface [polypeptide binding]; other site 196627006771 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 196627006772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196627006773 dimer interface [polypeptide binding]; other site 196627006774 conserved gate region; other site 196627006775 putative PBP binding loops; other site 196627006776 ABC-ATPase subunit interface; other site 196627006777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196627006778 dimer interface [polypeptide binding]; other site 196627006779 conserved gate region; other site 196627006780 putative PBP binding loops; other site 196627006781 ABC-ATPase subunit interface; other site 196627006782 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 196627006783 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 196627006784 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 196627006785 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 196627006786 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 196627006787 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 196627006788 Walker A/P-loop; other site 196627006789 ATP binding site [chemical binding]; other site 196627006790 Q-loop/lid; other site 196627006791 ABC transporter signature motif; other site 196627006792 Walker B; other site 196627006793 D-loop; other site 196627006794 H-loop/switch region; other site 196627006795 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 196627006796 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 196627006797 active site 196627006798 catalytic residues [active] 196627006799 DNA binding site [nucleotide binding] 196627006800 Int/Topo IB signature motif; other site 196627006801 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 196627006802 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 196627006803 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 196627006804 catalytic residues [active] 196627006805 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 196627006806 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 196627006807 AIR carboxylase; Region: AIRC; smart01001 196627006808 Uncharacterized conserved protein [Function unknown]; Region: COG1641 196627006809 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 196627006810 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 196627006811 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 196627006812 classical (c) SDRs; Region: SDR_c; cd05233 196627006813 NAD(P) binding site [chemical binding]; other site 196627006814 active site 196627006815 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 196627006816 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 196627006817 catalytic site [active] 196627006818 putative active site [active] 196627006819 putative substrate binding site [chemical binding]; other site 196627006820 dimer interface [polypeptide binding]; other site 196627006821 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 196627006822 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 196627006823 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 196627006824 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 196627006825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 196627006826 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 196627006827 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 196627006828 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 196627006829 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 196627006830 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 196627006831 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 196627006832 Transposase; Region: DDE_Tnp_ISL3; pfam01610 196627006833 glutaminase; Provisional; Region: PRK00971 196627006834 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 196627006835 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 196627006836 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 196627006837 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 196627006838 AAA domain; Region: AAA_33; pfam13671 196627006839 ATP-binding site [chemical binding]; other site 196627006840 Gluconate-6-phosphate binding site [chemical binding]; other site 196627006841 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 196627006842 active site 196627006843 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 196627006844 catalytic triad [active] 196627006845 conserved cis-peptide bond; other site 196627006846 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 196627006847 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 196627006848 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 196627006849 catalytic triad [active] 196627006850 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 196627006851 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 196627006852 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 196627006853 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196627006854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627006855 putative substrate translocation pore; other site 196627006856 Regulator of G protein signaling (RGS) domain superfamily; Region: RGS; cl02565 196627006857 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 196627006858 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 196627006859 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 196627006860 phosphate binding site [ion binding]; other site 196627006861 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 196627006862 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 196627006863 active site 2 [active] 196627006864 active site 1 [active] 196627006865 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 196627006866 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 196627006867 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196627006868 NAD(P) binding site [chemical binding]; other site 196627006869 active site 196627006870 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 196627006871 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 196627006872 active site 196627006873 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 196627006874 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 196627006875 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 196627006876 Peptidase family M23; Region: Peptidase_M23; pfam01551 196627006877 Glucitol operon activator [Transcription]; Region: GutM; COG4578 196627006878 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 196627006879 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 196627006880 active site 196627006881 dimerization interface [polypeptide binding]; other site 196627006882 ribonuclease PH; Reviewed; Region: rph; PRK00173 196627006883 Ribonuclease PH; Region: RNase_PH_bact; cd11362 196627006884 hexamer interface [polypeptide binding]; other site 196627006885 active site 196627006886 DDE domain; Region: DDE_Tnp_IS240; pfam13610 196627006887 Integrase core domain; Region: rve; pfam00665 196627006888 Predicted membrane protein [Function unknown]; Region: COG4325 196627006889 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 196627006890 DDE domain; Region: DDE_Tnp_IS240; pfam13610 196627006891 Integrase core domain; Region: rve; pfam00665 196627006892 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 196627006893 glutamate racemase; Provisional; Region: PRK00865 196627006894 Merozoite surface antigen 2c; Region: MSA-2c; pfam12238 196627006895 Transcriptional regulators [Transcription]; Region: MarR; COG1846 196627006896 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 196627006897 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 196627006898 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 196627006899 putative active site pocket [active] 196627006900 cleavage site 196627006901 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 196627006902 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 196627006903 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 196627006904 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 196627006905 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 196627006906 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 196627006907 active site 196627006908 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 196627006909 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708 196627006910 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 196627006911 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 196627006912 Peptidyl-tRNA hydrolase [Translation, ribosomal structure and biogenesis]; Region: pth2; COG1990 196627006913 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 196627006914 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 196627006915 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 196627006916 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 196627006917 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 196627006918 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196627006919 motif II; other site 196627006920 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 196627006921 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 196627006922 D-pathway; other site 196627006923 Putative ubiquinol binding site [chemical binding]; other site 196627006924 Low-spin heme (heme b) binding site [chemical binding]; other site 196627006925 Putative water exit pathway; other site 196627006926 Binuclear center (heme o3/CuB) [ion binding]; other site 196627006927 K-pathway; other site 196627006928 Putative proton exit pathway; other site 196627006929 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 196627006930 dimer interface [polypeptide binding]; other site 196627006931 putative radical transfer pathway; other site 196627006932 diiron center [ion binding]; other site 196627006933 tyrosyl radical; other site 196627006934 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 196627006935 Ferritin-like domain; Region: Ferritin; pfam00210 196627006936 ferroxidase diiron center [ion binding]; other site 196627006937 Transcriptional regulators [Transcription]; Region: FadR; COG2186 196627006938 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 196627006939 DNA-binding site [nucleotide binding]; DNA binding site 196627006940 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 196627006941 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 196627006942 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 196627006943 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 196627006944 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 196627006945 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 196627006946 Class I ribonucleotide reductase; Region: RNR_I; cd01679 196627006947 active site 196627006948 dimer interface [polypeptide binding]; other site 196627006949 catalytic residues [active] 196627006950 effector binding site; other site 196627006951 R2 peptide binding site; other site 196627006952 Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780 196627006953 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 196627006954 catalytic residues [active] 196627006955 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 196627006956 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 196627006957 homodimer interface [polypeptide binding]; other site 196627006958 NAD binding pocket [chemical binding]; other site 196627006959 ATP binding pocket [chemical binding]; other site 196627006960 Mg binding site [ion binding]; other site 196627006961 active-site loop [active] 196627006962 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3001 196627006963 Phosphotransferase enzyme family; Region: APH; pfam01636 196627006964 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 196627006965 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 196627006966 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 196627006967 NADP binding site [chemical binding]; other site 196627006968 dimer interface [polypeptide binding]; other site 196627006969 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 196627006970 (2R)-phospho-3-sulfolactate synthase (PSL synthase, CoM biosynthesis) [Coenzyme transport and metabolism]; Region: COG1809 196627006971 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 196627006972 phosphoglucomutase; Validated; Region: PRK07564 196627006973 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 196627006974 active site 196627006975 substrate binding site [chemical binding]; other site 196627006976 metal binding site [ion binding]; metal-binding site 196627006977 camphor resistance protein CrcB; Provisional; Region: ccrB; PRK00134 196627006978 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 196627006979 hypothetical protein; Provisional; Region: PRK05463 196627006980 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 196627006981 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 196627006982 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 196627006983 LGFP repeat; Region: LGFP; pfam08310 196627006984 LGFP repeat; Region: LGFP; pfam08310 196627006985 LGFP repeat; Region: LGFP; pfam08310 196627006986 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 196627006987 DDE superfamily endonuclease; Region: DDE_3; cl19249 196627006988 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 196627006989 Predicted membrane protein [General function prediction only]; Region: COG4194 196627006990 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 196627006991 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 196627006992 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 196627006993 FtsX-like permease family; Region: FtsX; pfam02687 196627006994 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 196627006995 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 196627006996 FtsX-like permease family; Region: FtsX; pfam02687 196627006997 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 196627006998 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 196627006999 Walker A/P-loop; other site 196627007000 ATP binding site [chemical binding]; other site 196627007001 Q-loop/lid; other site 196627007002 ABC transporter signature motif; other site 196627007003 Walker B; other site 196627007004 D-loop; other site 196627007005 H-loop/switch region; other site 196627007006 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 196627007007 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 196627007008 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 196627007009 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 196627007010 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 196627007011 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 196627007012 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196627007013 S-adenosylmethionine binding site [chemical binding]; other site 196627007014 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 196627007015 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 196627007016 hinge; other site 196627007017 active site 196627007018 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 196627007019 GAF domain; Region: GAF_2; pfam13185 196627007020 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 196627007021 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 196627007022 DNA binding residues [nucleotide binding] 196627007023 dimerization interface [polypeptide binding]; other site 196627007024 cysteine synthase; Region: PLN02565 196627007025 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 196627007026 dimer interface [polypeptide binding]; other site 196627007027 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196627007028 catalytic residue [active] 196627007029 serine O-acetyltransferase; Region: cysE; TIGR01172 196627007030 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 196627007031 trimer interface [polypeptide binding]; other site 196627007032 active site 196627007033 substrate binding site [chemical binding]; other site 196627007034 CoA binding site [chemical binding]; other site 196627007035 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196627007036 Coenzyme A binding pocket [chemical binding]; other site 196627007037 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 196627007038 CoA binding domain; Region: CoA_binding; smart00881 196627007039 CoA-ligase; Region: Ligase_CoA; pfam00549 196627007040 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 196627007041 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 196627007042 CoA-ligase; Region: Ligase_CoA; pfam00549 196627007043 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 196627007044 catalytic residues [active] 196627007045 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 196627007046 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 196627007047 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 196627007048 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 196627007049 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 196627007050 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 196627007051 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 196627007052 FMN binding site [chemical binding]; other site 196627007053 active site 196627007054 catalytic residues [active] 196627007055 substrate binding site [chemical binding]; other site 196627007056 Phosphate uptake regulator [Inorganic ion transport and metabolism]; Region: PhoU; COG0704 196627007057 PhoU domain; Region: PhoU; pfam01895 196627007058 PhoU domain; Region: PhoU; pfam01895 196627007059 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 196627007060 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 196627007061 Walker A/P-loop; other site 196627007062 ATP binding site [chemical binding]; other site 196627007063 Q-loop/lid; other site 196627007064 ABC transporter signature motif; other site 196627007065 Walker B; other site 196627007066 D-loop; other site 196627007067 H-loop/switch region; other site 196627007068 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 196627007069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196627007070 dimer interface [polypeptide binding]; other site 196627007071 conserved gate region; other site 196627007072 putative PBP binding loops; other site 196627007073 ABC-ATPase subunit interface; other site 196627007074 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 196627007075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196627007076 dimer interface [polypeptide binding]; other site 196627007077 conserved gate region; other site 196627007078 putative PBP binding loops; other site 196627007079 ABC-ATPase subunit interface; other site 196627007080 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 196627007081 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 196627007082 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196627007083 Coenzyme A binding pocket [chemical binding]; other site 196627007084 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196627007085 Coenzyme A binding pocket [chemical binding]; other site 196627007086 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 196627007087 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 196627007088 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 196627007089 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 196627007090 heme-binding site [chemical binding]; other site 196627007091 4-amino-4-deoxychorismate lyase; Provisional; Region: PRK07849 196627007092 homodimer interface [polypeptide binding]; other site 196627007093 substrate-cofactor binding pocket; other site 196627007094 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196627007095 catalytic residue [active] 196627007096 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 196627007097 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 196627007098 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 196627007099 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 196627007100 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 196627007101 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 196627007102 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 196627007103 dimerization interface [polypeptide binding]; other site 196627007104 putative ATP binding site [chemical binding]; other site 196627007105 amidophosphoribosyltransferase; Provisional; Region: PRK07847 196627007106 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 196627007107 active site 196627007108 tetramer interface [polypeptide binding]; other site 196627007109 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 196627007110 active site 196627007111 SCP-2 sterol transfer family; Region: SCP2; cl01225 196627007112 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 196627007113 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 196627007114 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 196627007115 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 196627007116 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 196627007117 dimerization interface [polypeptide binding]; other site 196627007118 ATP binding site [chemical binding]; other site 196627007119 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 196627007120 dimerization interface [polypeptide binding]; other site 196627007121 ATP binding site [chemical binding]; other site 196627007122 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 196627007123 putative active site [active] 196627007124 catalytic triad [active] 196627007125 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 196627007126 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 196627007127 catalytic residues [active] 196627007128 dimer interface [polypeptide binding]; other site 196627007129 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 196627007130 Lamin Tail Domain; Region: LTD; pfam00932 196627007131 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 196627007132 generic binding surface II; other site 196627007133 generic binding surface I; other site 196627007134 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 196627007135 putative active site [active] 196627007136 putative catalytic site [active] 196627007137 putative Mg binding site IVb [ion binding]; other site 196627007138 putative phosphate binding site [ion binding]; other site 196627007139 putative DNA binding site [nucleotide binding]; other site 196627007140 putative Mg binding site IVa [ion binding]; other site 196627007141 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 196627007142 putative active site [active] 196627007143 putative Zn binding site [ion binding]; other site 196627007144 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 196627007145 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 196627007146 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 196627007147 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 196627007148 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 196627007149 ATP binding site [chemical binding]; other site 196627007150 active site 196627007151 phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional; Region: PRK13959 196627007152 substrate binding site [chemical binding]; other site 196627007153 adenylosuccinate lyase; Region: purB; TIGR00928 196627007154 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 196627007155 tetramer interface [polypeptide binding]; other site 196627007156 aspartate aminotransferase; Provisional; Region: PRK05764 196627007157 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 196627007158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196627007159 homodimer interface [polypeptide binding]; other site 196627007160 catalytic residue [active] 196627007161 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 196627007162 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 196627007163 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 196627007164 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 196627007165 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 196627007166 nucleotide binding site/active site [active] 196627007167 HIT family signature motif; other site 196627007168 catalytic residue [active] 196627007169 Methyltransferase domain; Region: Methyltransf_31; pfam13847 196627007170 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196627007171 S-adenosylmethionine binding site [chemical binding]; other site 196627007172 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 196627007173 POT family; Region: PTR2; cl17359 196627007174 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627007175 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 196627007176 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 196627007177 inhibitor-cofactor binding pocket; inhibition site 196627007178 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196627007179 catalytic residue [active] 196627007180 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 196627007181 AAA domain; Region: AAA_26; pfam13500 196627007182 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 196627007183 active site 196627007184 ADP binding site [chemical binding]; other site 196627007185 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 196627007186 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 196627007187 dimerization interface [polypeptide binding]; other site 196627007188 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 196627007189 dimer interface [polypeptide binding]; other site 196627007190 phosphorylation site [posttranslational modification] 196627007191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196627007192 ATP binding site [chemical binding]; other site 196627007193 Mg2+ binding site [ion binding]; other site 196627007194 G-X-G motif; other site 196627007195 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 196627007196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196627007197 active site 196627007198 phosphorylation site [posttranslational modification] 196627007199 intermolecular recognition site; other site 196627007200 dimerization interface [polypeptide binding]; other site 196627007201 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 196627007202 DNA binding site [nucleotide binding] 196627007203 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 196627007204 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 196627007205 DNA binding residues [nucleotide binding] 196627007206 dimer interface [polypeptide binding]; other site 196627007207 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 196627007208 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 196627007209 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 196627007210 dimer interface [polypeptide binding]; other site 196627007211 active site 196627007212 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 196627007213 substrate binding site [chemical binding]; other site 196627007214 catalytic residue [active] 196627007215 pyruvate dehydrogenase; Provisional; Region: PRK06546 196627007216 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 196627007217 PYR/PP interface [polypeptide binding]; other site 196627007218 dimer interface [polypeptide binding]; other site 196627007219 TPP binding site [chemical binding]; other site 196627007220 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 196627007221 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 196627007222 TPP-binding site [chemical binding]; other site 196627007223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627007224 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196627007225 putative substrate translocation pore; other site 196627007226 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 196627007227 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 196627007228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627007229 putative substrate translocation pore; other site 196627007230 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 196627007231 active site 196627007232 catalytic residues [active] 196627007233 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 196627007234 active site 196627007235 catalytic residues [active] 196627007236 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 196627007237 Transcriptional regulator [Transcription]; Region: LysR; COG0583 196627007238 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 196627007239 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 196627007240 dimerization interface [polypeptide binding]; other site 196627007241 substrate binding pocket [chemical binding]; other site 196627007242 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 196627007243 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 196627007244 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl17742 196627007245 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 196627007246 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 196627007247 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 196627007248 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196627007249 active site 196627007250 motif I; other site 196627007251 motif II; other site 196627007252 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 196627007253 Uncharacterized conserved protein [Function unknown]; Region: COG5646 196627007254 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 196627007255 Uncharacterized conserved protein [Function unknown]; Region: COG2966 196627007256 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 196627007257 Uncharacterized conserved protein [Function unknown]; Region: COG3610 196627007258 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 196627007259 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 196627007260 active site 196627007261 homotetramer interface [polypeptide binding]; other site 196627007262 META domain; Region: META; cl01245 196627007263 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 196627007264 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 196627007265 Transcriptional regulators [Transcription]; Region: PurR; COG1609 196627007266 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 196627007267 DNA binding site [nucleotide binding] 196627007268 domain linker motif; other site 196627007269 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 196627007270 putative dimerization interface [polypeptide binding]; other site 196627007271 putative ligand binding site [chemical binding]; other site 196627007272 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 196627007273 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 196627007274 metal binding site [ion binding]; metal-binding site 196627007275 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 196627007276 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196627007277 Walker A/P-loop; other site 196627007278 ATP binding site [chemical binding]; other site 196627007279 Q-loop/lid; other site 196627007280 ABC transporter signature motif; other site 196627007281 Walker B; other site 196627007282 D-loop; other site 196627007283 H-loop/switch region; other site 196627007284 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 196627007285 ABC-ATPase subunit interface; other site 196627007286 dimer interface [polypeptide binding]; other site 196627007287 putative PBP binding regions; other site 196627007288 Winged helix-turn helix; Region: HTH_29; pfam13551 196627007289 Helix-turn-helix domain; Region: HTH_28; pfam13518 196627007290 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 196627007291 Integrase core domain; Region: rve; pfam00665 196627007292 Integrase core domain; Region: rve_3; pfam13683 196627007293 hypothetical protein; Provisional; Region: PRK12839 196627007294 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 196627007295 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 196627007296 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 196627007297 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 196627007298 Transcriptional regulator [Transcription]; Region: IclR; COG1414 196627007299 Bacterial transcriptional regulator; Region: IclR; pfam01614 196627007300 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 196627007301 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 196627007302 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 196627007303 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 196627007304 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 196627007305 active site 196627007306 HIGH motif; other site 196627007307 KMSKS motif; other site 196627007308 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 196627007309 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 196627007310 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 196627007311 active site turn [active] 196627007312 phosphorylation site [posttranslational modification] 196627007313 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 196627007314 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 196627007315 HPr interaction site; other site 196627007316 glycerol kinase (GK) interaction site [polypeptide binding]; other site 196627007317 active site 196627007318 phosphorylation site [posttranslational modification] 196627007319 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 196627007320 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 196627007321 substrate binding [chemical binding]; other site 196627007322 active site 196627007323 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 196627007324 active site 196627007325 trimer interface [polypeptide binding]; other site 196627007326 allosteric site; other site 196627007327 active site lid [active] 196627007328 hexamer (dimer of trimers) interface [polypeptide binding]; other site 196627007329 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 196627007330 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 196627007331 active site 196627007332 dimer interface [polypeptide binding]; other site 196627007333 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 196627007334 inhibitor site; inhibition site 196627007335 active site 196627007336 dimer interface [polypeptide binding]; other site 196627007337 catalytic residue [active] 196627007338 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 196627007339 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 196627007340 nucleotide binding site [chemical binding]; other site 196627007341 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 196627007342 putative active site cavity [active] 196627007343 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 196627007344 catalytic site [active] 196627007345 Asp-box motif; other site 196627007346 Transcriptional regulators [Transcription]; Region: FadR; COG2186 196627007347 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 196627007348 DNA-binding site [nucleotide binding]; DNA binding site 196627007349 FCD domain; Region: FCD; pfam07729 196627007350 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 196627007351 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 196627007352 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 196627007353 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 196627007354 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196627007355 dimer interface [polypeptide binding]; other site 196627007356 conserved gate region; other site 196627007357 putative PBP binding loops; other site 196627007358 ABC-ATPase subunit interface; other site 196627007359 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 196627007360 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 196627007361 Walker A/P-loop; other site 196627007362 ATP binding site [chemical binding]; other site 196627007363 Q-loop/lid; other site 196627007364 ABC transporter signature motif; other site 196627007365 Walker B; other site 196627007366 D-loop; other site 196627007367 H-loop/switch region; other site 196627007368 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 196627007369 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 196627007370 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 196627007371 Walker A/P-loop; other site 196627007372 ATP binding site [chemical binding]; other site 196627007373 Q-loop/lid; other site 196627007374 ABC transporter signature motif; other site 196627007375 Walker B; other site 196627007376 D-loop; other site 196627007377 H-loop/switch region; other site 196627007378 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 196627007379 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 196627007380 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 196627007381 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 196627007382 putative DNA binding site [nucleotide binding]; other site 196627007383 putative Zn2+ binding site [ion binding]; other site 196627007384 AsnC family; Region: AsnC_trans_reg; pfam01037 196627007385 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 196627007386 homotrimer interaction site [polypeptide binding]; other site 196627007387 zinc binding site [ion binding]; other site 196627007388 CDP-binding sites; other site 196627007389 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 196627007390 substrate binding site; other site 196627007391 dimer interface; other site 196627007392 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 196627007393 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 196627007394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196627007395 active site 196627007396 phosphorylation site [posttranslational modification] 196627007397 intermolecular recognition site; other site 196627007398 dimerization interface [polypeptide binding]; other site 196627007399 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 196627007400 DNA binding site [nucleotide binding] 196627007401 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 196627007402 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 196627007403 dimerization interface [polypeptide binding]; other site 196627007404 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 196627007405 dimer interface [polypeptide binding]; other site 196627007406 phosphorylation site [posttranslational modification] 196627007407 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196627007408 ATP binding site [chemical binding]; other site 196627007409 Mg2+ binding site [ion binding]; other site 196627007410 G-X-G motif; other site 196627007411 DNA repair protein RadA; Provisional; Region: PRK11823 196627007412 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 196627007413 Walker A motif; other site 196627007414 ATP binding site [chemical binding]; other site 196627007415 Walker B motif; other site 196627007416 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 196627007417 Predicted nucleic-acid-binding protein (contains the HHH domain) [General function prediction only]; Region: COG1623 196627007418 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 196627007419 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 196627007420 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 196627007421 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 196627007422 NAD(P) binding site [chemical binding]; other site 196627007423 catalytic residues [active] 196627007424 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 196627007425 active site clefts [active] 196627007426 zinc binding site [ion binding]; other site 196627007427 dimer interface [polypeptide binding]; other site 196627007428 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 196627007429 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 196627007430 minor groove reading motif; other site 196627007431 helix-hairpin-helix signature motif; other site 196627007432 substrate binding pocket [chemical binding]; other site 196627007433 active site 196627007434 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 196627007435 Mono-functional DNA-alkylating methyl methanesulfonate N-term; Region: MMS1_N; pfam10433 196627007436 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 196627007437 acetoin reductases; Region: 23BDH; TIGR02415 196627007438 NAD binding site [chemical binding]; other site 196627007439 homotetramer interface [polypeptide binding]; other site 196627007440 homodimer interface [polypeptide binding]; other site 196627007441 active site 196627007442 substrate binding site [chemical binding]; other site 196627007443 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 196627007444 Clp protease ATP binding subunit; Region: clpC; CHL00095 196627007445 Clp amino terminal domain; Region: Clp_N; pfam02861 196627007446 Clp amino terminal domain; Region: Clp_N; pfam02861 196627007447 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196627007448 Walker A motif; other site 196627007449 ATP binding site [chemical binding]; other site 196627007450 Walker B motif; other site 196627007451 arginine finger; other site 196627007452 UvrB/uvrC motif; Region: UVR; pfam02151 196627007453 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196627007454 Walker A motif; other site 196627007455 ATP binding site [chemical binding]; other site 196627007456 Walker B motif; other site 196627007457 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 196627007458 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 196627007459 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 196627007460 active site 196627007461 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 196627007462 AraC-binding-like domain; Region: AraC_binding_2; pfam14525 196627007463 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 196627007464 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 196627007465 phenol 2-monooxygenase; Provisional; Region: PRK08294 196627007466 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 196627007467 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979 196627007468 dimer interface [polypeptide binding]; other site 196627007469 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196627007470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627007471 putative substrate translocation pore; other site 196627007472 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 196627007473 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 196627007474 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 196627007475 dimer interface [polypeptide binding]; other site 196627007476 putative anticodon binding site; other site 196627007477 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 196627007478 motif 1; other site 196627007479 dimer interface [polypeptide binding]; other site 196627007480 active site 196627007481 motif 2; other site 196627007482 motif 3; other site 196627007483 Panthothenate synthetase [Coenzyme metabolism]; Region: PanC; COG0414 196627007484 active site 196627007485 nucleotide binding site [chemical binding]; other site 196627007486 HIGH motif; other site 196627007487 KMSKS motif; other site 196627007488 Rossmann-like domain; Region: Rossmann-like; pfam10727 196627007489 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 196627007490 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 196627007491 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 196627007492 catalytic center binding site [active] 196627007493 ATP binding site [chemical binding]; other site 196627007494 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 196627007495 homooctamer interface [polypeptide binding]; other site 196627007496 active site 196627007497 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 196627007498 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 196627007499 substrate binding pocket [chemical binding]; other site 196627007500 dimer interface [polypeptide binding]; other site 196627007501 inhibitor binding site; inhibition site 196627007502 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 196627007503 active site 196627007504 FtsH Extracellular; Region: FtsH_ext; pfam06480 196627007505 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 196627007506 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196627007507 Walker A motif; other site 196627007508 ATP binding site [chemical binding]; other site 196627007509 Walker B motif; other site 196627007510 arginine finger; other site 196627007511 Peptidase family M41; Region: Peptidase_M41; pfam01434 196627007512 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 196627007513 active site 196627007514 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 196627007515 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 196627007516 Ligand Binding Site [chemical binding]; other site 196627007517 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 196627007518 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 196627007519 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 196627007520 dimer interface [polypeptide binding]; other site 196627007521 substrate binding site [chemical binding]; other site 196627007522 metal binding sites [ion binding]; metal-binding site 196627007523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627007524 putative substrate translocation pore; other site 196627007525 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 196627007526 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196627007527 S-adenosylmethionine binding site [chemical binding]; other site 196627007528 Predicted membrane protein [Function unknown]; Region: COG3766 196627007529 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 196627007530 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 196627007531 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 196627007532 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 196627007533 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 196627007534 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl19164 196627007535 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 196627007536 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 196627007537 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 196627007538 Reductase C-terminal; Region: Reductase_C; pfam14759 196627007539 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 196627007540 active site residue [active] 196627007541 Transcriptional regulators [Transcription]; Region: MarR; COG1846 196627007542 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 196627007543 The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); Region: A_NRPS_SidN3_like; cd05918 196627007544 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 196627007545 acyl-activating enzyme (AAE) consensus motif; other site 196627007546 AMP binding site [chemical binding]; other site 196627007547 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 196627007548 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 196627007549 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 196627007550 putative CoA binding site [chemical binding]; other site 196627007551 putative trimer interface [polypeptide binding]; other site 196627007552 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 196627007553 putative trimer interface [polypeptide binding]; other site 196627007554 putative CoA binding site [chemical binding]; other site 196627007555 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 196627007556 NAD(P) binding site [chemical binding]; other site 196627007557 catalytic residues [active] 196627007558 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 196627007559 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 196627007560 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 196627007561 ring oligomerisation interface [polypeptide binding]; other site 196627007562 ATP/Mg binding site [chemical binding]; other site 196627007563 stacking interactions; other site 196627007564 hinge regions; other site 196627007565 Procyclic acidic repetitive protein (PARP); Region: Trypan_PARP; pfam05887 196627007566 Tubulin like; Region: Tubulin_2; pfam13809 196627007567 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 196627007568 metal ion-dependent adhesion site (MIDAS); other site 196627007569 hypothetical protein; Provisional; Region: PRK08201 196627007570 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 196627007571 active site 196627007572 metal binding site [ion binding]; metal-binding site 196627007573 dimer interface [polypeptide binding]; other site 196627007574 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 196627007575 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 196627007576 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 196627007577 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 196627007578 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 196627007579 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 196627007580 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 196627007581 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 196627007582 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 196627007583 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 196627007584 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948 196627007585 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12592 196627007586 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 196627007587 Putative lysophospholipase; Region: Hydrolase_4; cl19140 196627007588 carboxylate-amine ligase; Provisional; Region: PRK13517 196627007589 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 196627007590 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 196627007591 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 196627007592 active site 196627007593 catalytic residues [active] 196627007594 metal binding site [ion binding]; metal-binding site 196627007595 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196627007596 Coenzyme A binding pocket [chemical binding]; other site 196627007597 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 196627007598 putative catalytic site [active] 196627007599 putative phosphate binding site [ion binding]; other site 196627007600 active site 196627007601 metal binding site A [ion binding]; metal-binding site 196627007602 DNA binding site [nucleotide binding] 196627007603 putative AP binding site [nucleotide binding]; other site 196627007604 putative metal binding site B [ion binding]; other site 196627007605 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 196627007606 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 196627007607 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 196627007608 putative active site [active] 196627007609 catalytic site [active] 196627007610 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 196627007611 putative active site [active] 196627007612 catalytic site [active] 196627007613 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 196627007614 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627007615 putative substrate translocation pore; other site 196627007616 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 196627007617 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 196627007618 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 196627007619 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 196627007620 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 196627007621 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 196627007622 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 196627007623 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 196627007624 Walker A/P-loop; other site 196627007625 ATP binding site [chemical binding]; other site 196627007626 Q-loop/lid; other site 196627007627 ABC transporter signature motif; other site 196627007628 Walker B; other site 196627007629 D-loop; other site 196627007630 H-loop/switch region; other site 196627007631 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 196627007632 nudix motif; other site 196627007633 CHASE3 domain; Region: CHASE3; cl05000 196627007634 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 196627007635 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 196627007636 substrate binding pocket [chemical binding]; other site 196627007637 membrane-bound complex binding site; other site 196627007638 hinge residues; other site 196627007639 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 196627007640 Catalytic domain of Protein Kinases; Region: PKc; cd00180 196627007641 active site 196627007642 ATP binding site [chemical binding]; other site 196627007643 substrate binding site [chemical binding]; other site 196627007644 activation loop (A-loop); other site 196627007645 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 196627007646 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 196627007647 ferredoxin-NADP+ reductase; Region: PLN02852 196627007648 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 196627007649 Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153 196627007650 DNA translocase FtsK; Provisional; Region: PRK10263 196627007651 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 196627007652 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196627007653 ATP-grasp domain; Region: ATP-grasp_4; cl17255 196627007654 putative transposase OrfB; Reviewed; Region: PHA02517 196627007655 HTH-like domain; Region: HTH_21; pfam13276 196627007656 Integrase core domain; Region: rve; pfam00665 196627007657 Integrase core domain; Region: rve_3; pfam13683 196627007658 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 196627007659 Transposase; Region: HTH_Tnp_1; pfam01527 196627007660 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 196627007661 Histidine kinase; Region: HisKA_3; pfam07730 196627007662 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 196627007663 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 196627007664 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196627007665 active site 196627007666 phosphorylation site [posttranslational modification] 196627007667 intermolecular recognition site; other site 196627007668 dimerization interface [polypeptide binding]; other site 196627007669 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 196627007670 DNA binding residues [nucleotide binding] 196627007671 dimerization interface [polypeptide binding]; other site 196627007672 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 196627007673 GDP-binding site [chemical binding]; other site 196627007674 ACT binding site; other site 196627007675 IMP binding site; other site 196627007676 cardiolipin synthetase; Reviewed; Region: PRK12452 196627007677 Predicted membrane protein [Function unknown]; Region: COG4129 196627007678 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 196627007679 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 196627007680 active site 196627007681 intersubunit interface [polypeptide binding]; other site 196627007682 zinc binding site [ion binding]; other site 196627007683 Na+ binding site [ion binding]; other site 196627007684 Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833 196627007685 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 196627007686 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 196627007687 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 196627007688 active site 196627007689 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 196627007690 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 196627007691 active site residue [active] 196627007692 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 196627007693 active site residue [active] 196627007694 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196627007695 sequence-specific DNA binding site [nucleotide binding]; other site 196627007696 salt bridge; other site 196627007697 H+ Antiporter protein; Region: 2A0121; TIGR00900 196627007698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627007699 putative substrate translocation pore; other site 196627007700 Domain of unknown function (DUF4265); Region: DUF4265; pfam14085 196627007701 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 196627007702 Clp amino terminal domain; Region: Clp_N; pfam02861 196627007703 Clp amino terminal domain; Region: Clp_N; pfam02861 196627007704 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196627007705 Walker A motif; other site 196627007706 ATP binding site [chemical binding]; other site 196627007707 Walker B motif; other site 196627007708 arginine finger; other site 196627007709 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 196627007710 Protein of unknown function (DUF2730); Region: DUF2730; pfam10805 196627007711 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196627007712 Walker A motif; other site 196627007713 ATP binding site [chemical binding]; other site 196627007714 Walker B motif; other site 196627007715 arginine finger; other site 196627007716 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 196627007717 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 196627007718 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 196627007719 putative DNA binding site [nucleotide binding]; other site 196627007720 dimerization interface [polypeptide binding]; other site 196627007721 putative Zn2+ binding site [ion binding]; other site 196627007722 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 196627007723 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 196627007724 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 196627007725 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 196627007726 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 196627007727 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 196627007728 homodimer interface [polypeptide binding]; other site 196627007729 substrate-cofactor binding pocket; other site 196627007730 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196627007731 catalytic residue [active] 196627007732 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 196627007733 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196627007734 non-specific DNA binding site [nucleotide binding]; other site 196627007735 salt bridge; other site 196627007736 sequence-specific DNA binding site [nucleotide binding]; other site 196627007737 Cupin domain; Region: Cupin_2; pfam07883 196627007738 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861 196627007739 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 196627007740 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 196627007741 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 196627007742 FAD binding pocket [chemical binding]; other site 196627007743 FAD binding motif [chemical binding]; other site 196627007744 phosphate binding motif [ion binding]; other site 196627007745 beta-alpha-beta structure motif; other site 196627007746 NAD binding pocket [chemical binding]; other site 196627007747 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 196627007748 putative active site [active] 196627007749 catalytic triad [active] 196627007750 putative dimer interface [polypeptide binding]; other site 196627007751 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 196627007752 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Region: ALDH_ACDHII_AcoD-like; cd07559 196627007753 NAD(P) binding site [chemical binding]; other site 196627007754 catalytic residues [active] 196627007755 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 196627007756 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 196627007757 DNA binding residues [nucleotide binding] 196627007758 putative dimer interface [polypeptide binding]; other site 196627007759 chaperone protein DnaJ; Provisional; Region: PRK14279 196627007760 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 196627007761 HSP70 interaction site [polypeptide binding]; other site 196627007762 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 196627007763 substrate binding site [polypeptide binding]; other site 196627007764 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 196627007765 Zn binding sites [ion binding]; other site 196627007766 dimer interface [polypeptide binding]; other site 196627007767 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 196627007768 dimer interface [polypeptide binding]; other site 196627007769 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 196627007770 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 196627007771 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 196627007772 nucleotide binding site [chemical binding]; other site 196627007773 NEF interaction site [polypeptide binding]; other site 196627007774 SBD interface [polypeptide binding]; other site 196627007775 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 196627007776 nucleosidase; Provisional; Region: PRK05634 196627007777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 196627007778 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 196627007779 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 196627007780 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 196627007781 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196627007782 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 196627007783 Walker A/P-loop; other site 196627007784 Walker A/P-loop; other site 196627007785 ATP binding site [chemical binding]; other site 196627007786 ATP binding site [chemical binding]; other site 196627007787 Q-loop/lid; other site 196627007788 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 196627007789 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 196627007790 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 196627007791 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 196627007792 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 196627007793 NAD binding site [chemical binding]; other site 196627007794 substrate binding site [chemical binding]; other site 196627007795 catalytic Zn binding site [ion binding]; other site 196627007796 tetramer interface [polypeptide binding]; other site 196627007797 structural Zn binding site [ion binding]; other site 196627007798 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 196627007799 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 196627007800 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 196627007801 putative active site [active] 196627007802 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 196627007803 active site 196627007804 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 196627007805 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 196627007806 CysD dimerization site [polypeptide binding]; other site 196627007807 G1 box; other site 196627007808 putative GEF interaction site [polypeptide binding]; other site 196627007809 GTP/Mg2+ binding site [chemical binding]; other site 196627007810 Switch I region; other site 196627007811 G2 box; other site 196627007812 G3 box; other site 196627007813 Switch II region; other site 196627007814 G4 box; other site 196627007815 G5 box; other site 196627007816 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 196627007817 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 196627007818 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 196627007819 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 196627007820 Active Sites [active] 196627007821 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 196627007822 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 196627007823 Active Sites [active] 196627007824 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 196627007825 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 196627007826 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 196627007827 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 196627007828 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 196627007829 ferredoxin-NADP+ reductase; Region: PLN02852 196627007830 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 196627007831 Fic family protein [Function unknown]; Region: COG3177 196627007832 Fic/DOC family; Region: Fic; pfam02661 196627007833 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 196627007834 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 196627007835 dimer interface [polypeptide binding]; other site 196627007836 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 196627007837 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 196627007838 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 196627007839 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 196627007840 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 196627007841 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 196627007842 Walker A/P-loop; other site 196627007843 ATP binding site [chemical binding]; other site 196627007844 Q-loop/lid; other site 196627007845 ABC transporter signature motif; other site 196627007846 Walker B; other site 196627007847 D-loop; other site 196627007848 H-loop/switch region; other site 196627007849 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 196627007850 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 196627007851 Walker A/P-loop; other site 196627007852 ATP binding site [chemical binding]; other site 196627007853 Q-loop/lid; other site 196627007854 ABC transporter signature motif; other site 196627007855 Walker B; other site 196627007856 D-loop; other site 196627007857 H-loop/switch region; other site 196627007858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627007859 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196627007860 putative substrate translocation pore; other site 196627007861 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 196627007862 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 196627007863 putative metal binding site [ion binding]; other site 196627007864 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 196627007865 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 196627007866 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 196627007867 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196627007868 ABC transporter signature motif; other site 196627007869 Walker B; other site 196627007870 D-loop; other site 196627007871 H-loop/switch region; other site 196627007872 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 196627007873 Walker A/P-loop; other site 196627007874 ATP binding site [chemical binding]; other site 196627007875 ABC transporter signature motif; other site 196627007876 Walker B; other site 196627007877 D-loop; other site 196627007878 H-loop/switch region; other site 196627007879 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 196627007880 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 196627007881 dimer interface [polypeptide binding]; other site 196627007882 FMN binding site [chemical binding]; other site 196627007883 NADPH bind site [chemical binding]; other site 196627007884 Inosine-uridine nucleoside N-ribohydrolase [Nucleotide transport and metabolism]; Region: URH1; COG1957 196627007885 active site 196627007886 Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like_u2; cd03402 196627007887 prohibitin homologues; Region: PHB; smart00244 196627007888 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 196627007889 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 196627007890 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 196627007891 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 196627007892 heme-binding site [chemical binding]; other site 196627007893 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 196627007894 FAD binding pocket [chemical binding]; other site 196627007895 conserved FAD binding motif [chemical binding]; other site 196627007896 phosphate binding motif [ion binding]; other site 196627007897 beta-alpha-beta structure motif; other site 196627007898 NAD binding pocket [chemical binding]; other site 196627007899 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 196627007900 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 196627007901 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 196627007902 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 196627007903 PRD domain; Region: PRD; pfam00874 196627007904 PRD domain; Region: PRD; pfam00874 196627007905 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 196627007906 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 196627007907 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 196627007908 H-loop/switch region; other site 196627007909 aminotransferase AlaT; Validated; Region: PRK09265 196627007910 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 196627007911 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196627007912 homodimer interface [polypeptide binding]; other site 196627007913 catalytic residue [active] 196627007914 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 196627007915 Helix-turn-helix domain; Region: HTH_38; pfam13936 196627007916 Homeodomain-like domain; Region: HTH_32; pfam13565 196627007917 Integrase core domain; Region: rve; pfam00665 196627007918 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 196627007919 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 196627007920 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 196627007921 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 196627007922 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 196627007923 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 196627007924 trimer interface [polypeptide binding]; other site 196627007925 active site 196627007926 Htaa; Region: HtaA; pfam04213 196627007927 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 196627007928 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 196627007929 VanW like protein; Region: VanW; pfam04294 196627007930 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 196627007931 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 196627007932 Ligand Binding Site [chemical binding]; other site 196627007933 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 196627007934 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 196627007935 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 196627007936 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 196627007937 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 196627007938 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 196627007939 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196627007940 S-adenosylmethionine binding site [chemical binding]; other site 196627007941 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 196627007942 active site 196627007943 substrate-binding site [chemical binding]; other site 196627007944 metal-binding site [ion binding] 196627007945 GTP binding site [chemical binding]; other site 196627007946 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 196627007947 gating phenylalanine in ion channel; other site 196627007948 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196627007949 S-adenosylmethionine binding site [chemical binding]; other site 196627007950 LabA_like proteins; Region: LabA_like; cd06167 196627007951 putative metal binding site [ion binding]; other site 196627007952 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 196627007953 MMPL family; Region: MMPL; cl14618 196627007954 MMPL family; Region: MMPL; cl14618 196627007955 Predicted integral membrane protein [Function unknown]; Region: COG0392 196627007956 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 196627007957 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 196627007958 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 196627007959 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 196627007960 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 196627007961 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 196627007962 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 196627007963 active site 196627007964 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 196627007965 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 196627007966 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 196627007967 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 196627007968 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 196627007969 acyl-activating enzyme (AAE) consensus motif; other site 196627007970 active site 196627007971 Cutinase; Region: Cutinase; pfam01083 196627007972 Putative esterase; Region: Esterase; pfam00756 196627007973 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 196627007974 S-formylglutathione hydrolase; Region: PLN02442 196627007975 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 196627007976 LGFP repeat; Region: LGFP; pfam08310 196627007977 LGFP repeat; Region: LGFP; pfam08310 196627007978 LGFP repeat; Region: LGFP; pfam08310 196627007979 Domain of unknown function (DUF222); Region: DUF222; pfam02720 196627007980 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 196627007981 active site 196627007982 Putative esterase; Region: Esterase; pfam00756 196627007983 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 196627007984 UbiA family of prenyltransferases (PTases), Unknown subgroup; Region: PT_UbiA_2; cd13963 196627007985 putative active site [active] 196627007986 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 196627007987 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 196627007988 active site 196627007989 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 196627007990 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 196627007991 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 196627007992 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 196627007993 active site 196627007994 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 196627007995 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 196627007996 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 196627007997 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 196627007998 UDP-galactopyranose mutase; Region: GLF; pfam03275 196627007999 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 196627008000 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 196627008001 amidase catalytic site [active] 196627008002 Zn binding residues [ion binding]; other site 196627008003 substrate binding site [chemical binding]; other site 196627008004 LGFP repeat; Region: LGFP; pfam08310 196627008005 glycerol kinase; Provisional; Region: glpK; PRK00047 196627008006 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 196627008007 nucleotide binding site [chemical binding]; other site 196627008008 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196627008009 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 196627008010 active site 196627008011 motif I; other site 196627008012 motif II; other site 196627008013 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196627008014 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 196627008015 putative acyl-acceptor binding pocket; other site 196627008016 seryl-tRNA synthetase; Provisional; Region: PRK05431 196627008017 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 196627008018 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 196627008019 dimer interface [polypeptide binding]; other site 196627008020 active site 196627008021 motif 1; other site 196627008022 motif 2; other site 196627008023 motif 3; other site 196627008024 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 196627008025 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 196627008026 DNA-binding site [nucleotide binding]; DNA binding site 196627008027 UTRA domain; Region: UTRA; pfam07702 196627008028 Septum formation; Region: Septum_form; pfam13845 196627008029 Septum formation; Region: Septum_form; pfam13845 196627008030 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 196627008031 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 196627008032 catalytic core [active] 196627008033 prephenate dehydratase; Provisional; Region: PRK11898 196627008034 Prephenate dehydratase; Region: PDT; pfam00800 196627008035 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 196627008036 putative L-Phe binding site [chemical binding]; other site 196627008037 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 196627008038 CAAX protease self-immunity; Region: Abi; pfam02517 196627008039 Transcriptional regulator [Transcription]; Region: LytR; COG1316 196627008040 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 196627008041 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 196627008042 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 196627008043 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 196627008044 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 196627008045 putative active site [active] 196627008046 catalytic site [active] 196627008047 putative metal binding site [ion binding]; other site 196627008048 fructuronate transporter; Provisional; Region: PRK10034; cl15264 196627008049 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 196627008050 pyruvate kinase; Provisional; Region: PRK14725 196627008051 pyruvate kinase; Validated; Region: PRK08187 196627008052 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 196627008053 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 196627008054 tetramer (dimer of dimers) interface [polypeptide binding]; other site 196627008055 NAD binding site [chemical binding]; other site 196627008056 dimer interface [polypeptide binding]; other site 196627008057 substrate binding site [chemical binding]; other site 196627008058 Predicted membrane protein [Function unknown]; Region: COG4425 196627008059 Alpha/beta-hydrolase family N-terminus; Region: Abhydrolase_9_N; pfam15420 196627008060 Alpha/beta-hydrolase family; Region: Abhydrolase_9; pfam10081 196627008061 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 196627008062 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196627008063 motif II; other site 196627008064 Predicted flavoprotein [General function prediction only]; Region: COG0431 196627008065 Transcriptional regulators [Transcription]; Region: FadR; COG2186 196627008066 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 196627008067 DNA-binding site [nucleotide binding]; DNA binding site 196627008068 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 196627008069 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 196627008070 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 196627008071 active site 196627008072 metal binding site [ion binding]; metal-binding site 196627008073 metabolite-proton symporter; Region: 2A0106; TIGR00883 196627008074 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627008075 putative substrate translocation pore; other site 196627008076 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 196627008077 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 196627008078 active site 196627008079 substrate binding site [chemical binding]; other site 196627008080 FMN binding site [chemical binding]; other site 196627008081 putative catalytic residues [active] 196627008082 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196627008083 non-specific DNA binding site [nucleotide binding]; other site 196627008084 salt bridge; other site 196627008085 sequence-specific DNA binding site [nucleotide binding]; other site 196627008086 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 196627008087 active site 196627008088 metal binding site [ion binding]; metal-binding site 196627008089 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 196627008090 Uncharacterized conserved protein [Function unknown]; Region: COG4894 196627008091 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 196627008092 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 196627008093 metal binding site [ion binding]; metal-binding site 196627008094 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 196627008095 methionine sulfoxide reductase A; Provisional; Region: PRK00058 196627008096 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 196627008097 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 196627008098 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 196627008099 Transcriptional regulator [Transcription]; Region: LysR; COG0583 196627008100 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 196627008101 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 196627008102 putative dimerization interface [polypeptide binding]; other site 196627008103 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627008104 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196627008105 putative substrate translocation pore; other site 196627008106 Cupredoxin superfamily; Region: Cupredoxin; cd00920 196627008107 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 196627008108 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 196627008109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627008110 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196627008111 putative substrate translocation pore; other site 196627008112 Transcriptional regulators [Transcription]; Region: MarR; COG1846 196627008113 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 196627008114 putative DNA binding site [nucleotide binding]; other site 196627008115 putative Zn2+ binding site [ion binding]; other site 196627008116 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 196627008117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196627008118 active site 196627008119 phosphorylation site [posttranslational modification] 196627008120 intermolecular recognition site; other site 196627008121 dimerization interface [polypeptide binding]; other site 196627008122 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 196627008123 DNA binding residues [nucleotide binding] 196627008124 dimerization interface [polypeptide binding]; other site 196627008125 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 196627008126 Histidine kinase; Region: HisKA_3; pfam07730 196627008127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196627008128 ATP binding site [chemical binding]; other site 196627008129 Mg2+ binding site [ion binding]; other site 196627008130 G-X-G motif; other site 196627008131 Domain of unknown function (DUF2020); Region: DUF2020; pfam09449 196627008132 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 196627008133 active site 196627008134 catalytic site [active] 196627008135 putative inner membrane protein translocase component YidC; Validated; Region: PRK00247 196627008136 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 196627008137 Protein of unknown function (DUF1168); Region: DUF1168; pfam06658 196627008138 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 196627008139 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 196627008140 Predicted membrane protein [Function unknown]; Region: COG2261 196627008141 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 196627008142 Ligand Binding Site [chemical binding]; other site 196627008143 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 196627008144 Ligand Binding Site [chemical binding]; other site 196627008145 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 196627008146 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 196627008147 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 196627008148 probable active site [active] 196627008149 Predicted transcriptional regulators [Transcription]; Region: COG1725 196627008150 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 196627008151 DNA-binding site [nucleotide binding]; DNA binding site 196627008152 LabA_like proteins; Region: LabA_like; cd06167 196627008153 putative metal binding site [ion binding]; other site 196627008154 Uncharacterized conserved protein [Function unknown]; Region: COG1432 196627008155 Ribosome receptor lysine/proline rich region; Region: Rib_recp_KP_reg; pfam05104 196627008156 Phosphoprotein; Region: PP_M1; pfam03012 196627008157 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 196627008158 Golgi-localized syntaxin-1-binding clamp; Region: Syntaphilin; pfam15290 196627008159 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 196627008160 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196627008161 S-adenosylmethionine binding site [chemical binding]; other site 196627008162 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 196627008163 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 196627008164 Ferredoxin [Energy production and conversion]; Region: COG1146 196627008165 4Fe-4S binding domain; Region: Fer4; pfam00037 196627008166 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 196627008167 Hexameric tyrosine-coordinated heme protein (HTHP); Region: HTHP; pfam11534 196627008168 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 196627008169 BAF1 / ABF1 chromatin reorganizing factor; Region: BAF1_ABF1; pfam04684 196627008170 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 196627008171 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 196627008172 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196627008173 motif I; other site 196627008174 motif II; other site 196627008175 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 196627008176 metal-binding site [ion binding] 196627008177 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 196627008178 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 196627008179 dimerization interface [polypeptide binding]; other site 196627008180 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 196627008181 dimer interface [polypeptide binding]; other site 196627008182 phosphorylation site [posttranslational modification] 196627008183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196627008184 ATP binding site [chemical binding]; other site 196627008185 Mg2+ binding site [ion binding]; other site 196627008186 G-X-G motif; other site 196627008187 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 196627008188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196627008189 active site 196627008190 phosphorylation site [posttranslational modification] 196627008191 intermolecular recognition site; other site 196627008192 dimerization interface [polypeptide binding]; other site 196627008193 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 196627008194 DNA binding site [nucleotide binding] 196627008195 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 196627008196 The first cupredoxin domain of CumA like multicopper oxidase; Region: CuRO_1_CumA_like; cd13861 196627008197 putative Domain 2 interface [polypeptide binding]; other site 196627008198 putative Domain 3 interface [polypeptide binding]; other site 196627008199 trinuclear Cu binding site [ion binding]; other site 196627008200 The second cupredoxin domain of CopA copper resistance protein like family; Region: CuRO_2_CopA_like_1; cd13870 196627008201 putative Domain 1 interface [polypeptide binding]; other site 196627008202 putative Domain 3 interface [polypeptide binding]; other site 196627008203 The third cupredoxin domain of CopA copper resistance protein family; Region: CuRO_3_CopA; cd13896 196627008204 putative Domain 2 interface [polypeptide binding]; other site 196627008205 Type 1 (T1) Cu binding site [ion binding]; other site 196627008206 putative Domain 1 interface [polypeptide binding]; other site 196627008207 trinuclear Cu binding site [ion binding]; other site 196627008208 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 196627008209 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 196627008210 putative NAD(P) binding site [chemical binding]; other site 196627008211 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 196627008212 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 196627008213 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 196627008214 metal-binding site [ion binding] 196627008215 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 196627008216 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 196627008217 Soluble P-type ATPase [General function prediction only]; Region: COG4087 196627008218 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 196627008219 catalytic residues [active] 196627008220 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 196627008221 metal-binding site [ion binding] 196627008222 benzoate transport; Region: 2A0115; TIGR00895 196627008223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627008224 putative substrate translocation pore; other site 196627008225 Predicted transcriptional regulators [Transcription]; Region: COG1695 196627008226 replicative DNA helicase; Provisional; Region: PRK05636 196627008227 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 196627008228 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 196627008229 Walker A motif; other site 196627008230 ATP binding site [chemical binding]; other site 196627008231 Walker B motif; other site 196627008232 DNA binding loops [nucleotide binding] 196627008233 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 196627008234 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 196627008235 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 196627008236 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 196627008237 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 196627008238 dimer interface [polypeptide binding]; other site 196627008239 ssDNA binding site [nucleotide binding]; other site 196627008240 tetramer (dimer of dimers) interface [polypeptide binding]; other site 196627008241 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 196627008242 Predicted integral membrane protein [Function unknown]; Region: COG5650 196627008243 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 196627008244 Transglycosylase; Region: Transgly; pfam00912 196627008245 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 196627008246 Transcriptional regulators [Transcription]; Region: MarR; COG1846 196627008247 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 196627008248 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 196627008249 Ligand Binding Site [chemical binding]; other site 196627008250 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 196627008251 Ligand Binding Site [chemical binding]; other site 196627008252 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 196627008253 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 196627008254 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 196627008255 active site residue [active] 196627008256 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 196627008257 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 196627008258 FtsX-like permease family; Region: FtsX; pfam02687 196627008259 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 196627008260 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 196627008261 Walker A/P-loop; other site 196627008262 ATP binding site [chemical binding]; other site 196627008263 Q-loop/lid; other site 196627008264 ABC transporter signature motif; other site 196627008265 Walker B; other site 196627008266 D-loop; other site 196627008267 H-loop/switch region; other site 196627008268 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 196627008269 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 196627008270 HlyD family secretion protein; Region: HlyD_3; pfam13437 196627008271 inositol 1-phosphate synthase, Actinobacterial type; Region: mycothiol_INO1; TIGR03450 196627008272 hypothetical protein; Provisional; Region: PRK13663 196627008273 Ferritin-like domain; Region: Ferritin; pfam00210 196627008274 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 196627008275 dimerization interface [polypeptide binding]; other site 196627008276 DPS ferroxidase diiron center [ion binding]; other site 196627008277 ion pore; other site 196627008278 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 196627008279 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 196627008280 putative DNA binding site [nucleotide binding]; other site 196627008281 catalytic residue [active] 196627008282 putative H2TH interface [polypeptide binding]; other site 196627008283 putative catalytic residues [active] 196627008284 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 196627008285 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 196627008286 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 196627008287 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 196627008288 putative active site [active] 196627008289 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 196627008290 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 196627008291 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 196627008292 DNA binding site [nucleotide binding] 196627008293 active site 196627008294 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 196627008295 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 196627008296 putative NAD(P) binding site [chemical binding]; other site 196627008297 dimer interface [polypeptide binding]; other site 196627008298 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 196627008299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627008300 putative substrate translocation pore; other site 196627008301 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 196627008302 Malic enzyme, N-terminal domain; Region: malic; pfam00390 196627008303 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 196627008304 putative NAD(P) binding site [chemical binding]; other site 196627008305 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 196627008306 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 196627008307 N- and C-terminal domain interface [polypeptide binding]; other site 196627008308 active site 196627008309 catalytic site [active] 196627008310 metal binding site [ion binding]; metal-binding site 196627008311 carbohydrate binding site [chemical binding]; other site 196627008312 ATP binding site [chemical binding]; other site 196627008313 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 196627008314 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 196627008315 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 196627008316 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 196627008317 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 196627008318 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 196627008319 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 196627008320 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 196627008321 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 196627008322 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 196627008323 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 196627008324 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 196627008325 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 196627008326 putative FMN binding site [chemical binding]; other site 196627008327 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 196627008328 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 196627008329 active site 196627008330 HIGH motif; other site 196627008331 nucleotide binding site [chemical binding]; other site 196627008332 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 196627008333 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 196627008334 active site 196627008335 KMSKS motif; other site 196627008336 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 196627008337 tRNA binding surface [nucleotide binding]; other site 196627008338 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 196627008339 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 196627008340 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196627008341 non-specific DNA binding site [nucleotide binding]; other site 196627008342 salt bridge; other site 196627008343 sequence-specific DNA binding site [nucleotide binding]; other site 196627008344 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 196627008345 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 196627008346 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 196627008347 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 196627008348 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 196627008349 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 196627008350 Cupin domain; Region: Cupin_2; pfam07883 196627008351 Transcriptional regulator [Transcription]; Region: IclR; COG1414 196627008352 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 196627008353 Bacterial transcriptional regulator; Region: IclR; pfam01614 196627008354 Baculoviral E56 protein, specific to ODV envelope; Region: Baculo_E56; pfam04639 196627008355 benzoate transport; Region: 2A0115; TIGR00895 196627008356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627008357 putative substrate translocation pore; other site 196627008358 salicylate hydroxylase; Provisional; Region: PRK08163 196627008359 Squalene epoxidase; Region: SE; cl17314 196627008360 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 196627008361 Predicted integral membrane protein [Function unknown]; Region: COG5658 196627008362 SdpI/YhfL protein family; Region: SdpI; pfam13630 196627008363 anthranilate synthase component I; Provisional; Region: PRK13564 196627008364 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 196627008365 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 196627008366 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 196627008367 Glutamine amidotransferase class-I; Region: GATase; pfam00117 196627008368 glutamine binding [chemical binding]; other site 196627008369 catalytic triad [active] 196627008370 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 196627008371 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 196627008372 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 196627008373 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 196627008374 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 196627008375 active site 196627008376 ribulose/triose binding site [chemical binding]; other site 196627008377 phosphate binding site [ion binding]; other site 196627008378 substrate (anthranilate) binding pocket [chemical binding]; other site 196627008379 product (indole) binding pocket [chemical binding]; other site 196627008380 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 196627008381 active site 196627008382 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 196627008383 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 196627008384 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196627008385 catalytic residue [active] 196627008386 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 196627008387 substrate binding site [chemical binding]; other site 196627008388 active site 196627008389 catalytic residues [active] 196627008390 heterodimer interface [polypeptide binding]; other site 196627008391 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 196627008392 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 196627008393 active site 196627008394 phosphorylation site [posttranslational modification] 196627008395 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 196627008396 active site 196627008397 P-loop; other site 196627008398 phosphorylation site [posttranslational modification] 196627008399 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 196627008400 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 196627008401 Walker A/P-loop; other site 196627008402 ATP binding site [chemical binding]; other site 196627008403 Q-loop/lid; other site 196627008404 ABC transporter signature motif; other site 196627008405 Walker B; other site 196627008406 D-loop; other site 196627008407 H-loop/switch region; other site 196627008408 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 196627008409 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 196627008410 iron-sulfur cluster [ion binding]; other site 196627008411 [2Fe-2S] cluster binding site [ion binding]; other site 196627008412 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 196627008413 active site 196627008414 FMN binding site [chemical binding]; other site 196627008415 substrate binding site [chemical binding]; other site 196627008416 homotetramer interface [polypeptide binding]; other site 196627008417 catalytic residue [active] 196627008418 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 196627008419 Uncharacterized conserved protein [Function unknown]; Region: COG3358 196627008420 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 196627008421 putative DNA binding site [nucleotide binding]; other site 196627008422 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 196627008423 active site 196627008424 FMN binding site [chemical binding]; other site 196627008425 substrate binding site [chemical binding]; other site 196627008426 homotetramer interface [polypeptide binding]; other site 196627008427 catalytic residue [active] 196627008428 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 196627008429 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196627008430 NAD(P) binding site [chemical binding]; other site 196627008431 active site 196627008432 short chain dehydrogenase; Provisional; Region: PRK08267 196627008433 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196627008434 NAD(P) binding site [chemical binding]; other site 196627008435 active site 196627008436 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 196627008437 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 196627008438 POT family; Region: PTR2; cl17359 196627008439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627008440 putative substrate translocation pore; other site 196627008441 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 196627008442 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 196627008443 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 196627008444 active site 196627008445 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 196627008446 active site 196627008447 dimer interface [polypeptide binding]; other site 196627008448 metal binding site [ion binding]; metal-binding site 196627008449 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 196627008450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627008451 putative substrate translocation pore; other site 196627008452 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 196627008453 Transcriptional regulator [Transcription]; Region: IclR; COG1414 196627008454 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 196627008455 Bacterial transcriptional regulator; Region: IclR; pfam01614 196627008456 Transcriptional regulator [Transcription]; Region: IclR; COG1414 196627008457 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 196627008458 Bacterial transcriptional regulator; Region: IclR; pfam01614 196627008459 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 196627008460 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 196627008461 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 196627008462 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 196627008463 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 196627008464 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 196627008465 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 196627008466 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 196627008467 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 196627008468 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 196627008469 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 196627008470 Lamin Tail Domain; Region: LTD; pfam00932 196627008471 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 196627008472 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 196627008473 putative active site [active] 196627008474 putative metal binding site [ion binding]; other site 196627008475 proline/glycine betaine transporter; Provisional; Region: PRK10642 196627008476 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627008477 putative substrate translocation pore; other site 196627008478 Uncharacterized prokaryotic subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_eoslipins_u2; cd13438 196627008479 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 196627008480 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 196627008481 GIY-YIG motif/motif A; other site 196627008482 active site 196627008483 catalytic site [active] 196627008484 metal binding site [ion binding]; metal-binding site 196627008485 Predicted helicase [General function prediction only]; Region: COG4889 196627008486 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 196627008487 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196627008488 ATP binding site [chemical binding]; other site 196627008489 putative Mg++ binding site [ion binding]; other site 196627008490 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196627008491 ATP-binding site [chemical binding]; other site 196627008492 Methyltransferase domain; Region: Methyltransf_26; pfam13659 196627008493 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 196627008494 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [Coenzyme metabolism]; Region: ThiD; COG0351 196627008495 ATP binding site [chemical binding]; other site 196627008496 substrate binding site [chemical binding]; other site 196627008497 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 196627008498 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 196627008499 DNA binding site [nucleotide binding] 196627008500 active site 196627008501 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 196627008502 metal-binding site [ion binding] 196627008503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196627008504 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 196627008505 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 196627008506 siderophore binding site; other site 196627008507 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 196627008508 2-enoyl thioester reductase (ETR) like proteins, child 2; Region: ETR_like_2; cd08292 196627008509 putative NAD(P) binding site [chemical binding]; other site 196627008510 putative dimer interface [polypeptide binding]; other site 196627008511 Predicted membrane protein [Function unknown]; Region: COG3759 196627008512 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 196627008513 substrate binding site [chemical binding]; other site 196627008514 dimer interface [polypeptide binding]; other site 196627008515 ATP binding site [chemical binding]; other site 196627008516 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 196627008517 metal-binding site [ion binding] 196627008518 Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687 196627008519 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 196627008520 hypothetical protein; Validated; Region: PRK00228 196627008521 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 196627008522 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 196627008523 active site 196627008524 NTP binding site [chemical binding]; other site 196627008525 metal binding triad [ion binding]; metal-binding site 196627008526 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 196627008527 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 196627008528 Zn2+ binding site [ion binding]; other site 196627008529 Mg2+ binding site [ion binding]; other site 196627008530 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 196627008531 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 196627008532 active site 196627008533 Ap6A binding site [chemical binding]; other site 196627008534 nudix motif; other site 196627008535 metal binding site [ion binding]; metal-binding site 196627008536 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 196627008537 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 196627008538 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 196627008539 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 196627008540 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 196627008541 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 196627008542 DNA binding residues [nucleotide binding] 196627008543 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 196627008544 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 196627008545 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 196627008546 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 196627008547 catalytic residues [active] 196627008548 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 196627008549 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 196627008550 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 196627008551 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 196627008552 active site 196627008553 metal binding site [ion binding]; metal-binding site 196627008554 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 196627008555 ParB-like nuclease domain; Region: ParB; smart00470 196627008556 KorB domain; Region: KorB; pfam08535 196627008557 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 196627008558 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 196627008559 P-loop; other site 196627008560 Magnesium ion binding site [ion binding]; other site 196627008561 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 196627008562 Methyltransferase domain; Region: Methyltransf_31; pfam13847 196627008563 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 196627008564 ribonuclease P; Reviewed; Region: rnpA; PRK03459 196627008565 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399