-- dump date   	20140619_051524
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
196627000001	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
196627000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196627000003	Walker A motif; other site
196627000004	ATP binding site [chemical binding]; other site
196627000005	Walker B motif; other site
196627000006	arginine finger; other site
196627000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
196627000008	DnaA box-binding interface [nucleotide binding]; other site
196627000009	DNA polymerase III subunit beta; Validated; Region: PRK07761
196627000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
196627000011	putative DNA binding surface [nucleotide binding]; other site
196627000012	dimer interface [polypeptide binding]; other site
196627000013	beta-clamp/clamp loader binding surface; other site
196627000014	beta-clamp/translesion DNA polymerase binding surface; other site
196627000015	recombination protein F; Reviewed; Region: recF; PRK00064
196627000016	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
196627000017	Walker A/P-loop; other site
196627000018	ATP binding site [chemical binding]; other site
196627000019	Q-loop/lid; other site
196627000020	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196627000021	ABC transporter signature motif; other site
196627000022	Walker B; other site
196627000023	D-loop; other site
196627000024	H-loop/switch region; other site
196627000025	hypothetical protein; Provisional; Region: PRK00111
196627000026	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
196627000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196627000028	ATP binding site [chemical binding]; other site
196627000029	Mg2+ binding site [ion binding]; other site
196627000030	G-X-G motif; other site
196627000031	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
196627000032	anchoring element; other site
196627000033	dimer interface [polypeptide binding]; other site
196627000034	ATP binding site [chemical binding]; other site
196627000035	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
196627000036	active site
196627000037	putative metal-binding site [ion binding]; other site
196627000038	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
196627000039	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
196627000040	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
196627000041	Predicted membrane protein [Function unknown]; Region: COG2364
196627000042	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
196627000043	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
196627000044	DNA gyrase subunit A; Validated; Region: PRK05560
196627000045	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
196627000046	CAP-like domain; other site
196627000047	active site
196627000048	primary dimer interface [polypeptide binding]; other site
196627000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
196627000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
196627000051	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
196627000052	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
196627000053	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
196627000054	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
196627000055	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
196627000056	Predicted membrane protein [Function unknown]; Region: COG2855
196627000057	Transcriptional regulator [Transcription]; Region: LysR; COG0583
196627000058	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
196627000059	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
196627000060	dimerization interface [polypeptide binding]; other site
196627000061	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
196627000062	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
196627000063	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
196627000064	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
196627000065	Predicted transcriptional regulator [Transcription]; Region: COG3682
196627000066	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
196627000067	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
196627000068	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
196627000069	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
196627000070	active site
196627000071	metal binding site [ion binding]; metal-binding site
196627000072	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
196627000073	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
196627000074	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
196627000075	Divergent AAA domain; Region: AAA_4; pfam04326
196627000076	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
196627000077	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
196627000078	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
196627000079	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
196627000080	intersubunit interface [polypeptide binding]; other site
196627000081	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
196627000082	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
196627000083	ABC-ATPase subunit  interface; other site
196627000084	dimer interface [polypeptide binding]; other site
196627000085	putative PBP binding regions; other site
196627000086	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
196627000087	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196627000088	Walker A/P-loop; other site
196627000089	ATP binding site [chemical binding]; other site
196627000090	Q-loop/lid; other site
196627000091	ABC transporter signature motif; other site
196627000092	Walker B; other site
196627000093	D-loop; other site
196627000094	H-loop/switch region; other site
196627000095	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
196627000096	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
196627000097	putative ligand binding site [chemical binding]; other site
196627000098	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
196627000099	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
196627000100	TM-ABC transporter signature motif; other site
196627000101	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
196627000102	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
196627000103	Walker A/P-loop; other site
196627000104	ATP binding site [chemical binding]; other site
196627000105	Q-loop/lid; other site
196627000106	ABC transporter signature motif; other site
196627000107	Walker B; other site
196627000108	D-loop; other site
196627000109	H-loop/switch region; other site
196627000110	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
196627000111	active site
196627000112	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
196627000113	Helix-turn-helix domain; Region: HTH_18; pfam12833
196627000114	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
196627000115	Helix-turn-helix domain; Region: HTH_18; pfam12833
196627000116	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
196627000117	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
196627000118	dimer interface [polypeptide binding]; other site
196627000119	putative PBP binding regions; other site
196627000120	ABC-ATPase subunit  interface; other site
196627000121	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
196627000122	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
196627000123	Walker A/P-loop; other site
196627000124	ATP binding site [chemical binding]; other site
196627000125	Q-loop/lid; other site
196627000126	ABC transporter signature motif; other site
196627000127	Walker B; other site
196627000128	D-loop; other site
196627000129	H-loop/switch region; other site
196627000130	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
196627000131	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
196627000132	FAD binding pocket [chemical binding]; other site
196627000133	FAD binding motif [chemical binding]; other site
196627000134	phosphate binding motif [ion binding]; other site
196627000135	NAD binding pocket [chemical binding]; other site
196627000136	putative septation inhibitor protein; Reviewed; Region: PRK00159
196627000137	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
196627000138	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
196627000139	active site
196627000140	ATP binding site [chemical binding]; other site
196627000141	substrate binding site [chemical binding]; other site
196627000142	activation loop (A-loop); other site
196627000143	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
196627000144	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
196627000145	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
196627000146	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
196627000147	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
196627000148	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
196627000149	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
196627000150	active site
196627000151	ATP binding site [chemical binding]; other site
196627000152	substrate binding site [chemical binding]; other site
196627000153	activation loop (A-loop); other site
196627000154	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
196627000155	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
196627000156	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
196627000157	Protein phosphatase 2C; Region: PP2C; pfam00481
196627000158	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
196627000159	active site
196627000160	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
196627000161	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
196627000162	phosphopeptide binding site; other site
196627000163	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
196627000164	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
196627000165	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
196627000166	phosphopeptide binding site; other site
196627000167	succinic semialdehyde dehydrogenase; Region: PLN02278
196627000168	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
196627000169	tetramerization interface [polypeptide binding]; other site
196627000170	NAD(P) binding site [chemical binding]; other site
196627000171	catalytic residues [active]
196627000172	FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979
196627000173	dimer interface [polypeptide binding]; other site
196627000174	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
196627000175	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
196627000176	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
196627000177	active site residue [active]
196627000178	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
196627000179	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
196627000180	active site residue [active]
196627000181	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
196627000182	active site residue [active]
196627000183	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
196627000184	putative homodimer interface [polypeptide binding]; other site
196627000185	putative homotetramer interface [polypeptide binding]; other site
196627000186	putative allosteric switch controlling residues; other site
196627000187	putative metal binding site [ion binding]; other site
196627000188	putative homodimer-homodimer interface [polypeptide binding]; other site
196627000189	Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750
196627000190	putative metal binding residues [ion binding]; other site
196627000191	signature motif; other site
196627000192	dimer interface [polypeptide binding]; other site
196627000193	active site
196627000194	polyP binding site; other site
196627000195	substrate binding site [chemical binding]; other site
196627000196	acceptor-phosphate pocket; other site
196627000197	MgtC family; Region: MgtC; pfam02308
196627000198	CotH protein; Region: CotH; pfam08757
196627000199	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
196627000200	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
196627000201	oligomer interface [polypeptide binding]; other site
196627000202	metal binding site [ion binding]; metal-binding site
196627000203	metal binding site [ion binding]; metal-binding site
196627000204	putative Cl binding site [ion binding]; other site
196627000205	basic sphincter; other site
196627000206	hydrophobic gate; other site
196627000207	periplasmic entrance; other site
196627000208	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
196627000209	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
196627000210	dimer interface [polypeptide binding]; other site
196627000211	hexamer interface [polypeptide binding]; other site
196627000212	active site 2 [active]
196627000213	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
196627000214	Putative ClC chloride channel.  Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033
196627000215	putative ion selectivity filter; other site
196627000216	putative pore gating glutamate residue; other site
196627000217	Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201
196627000218	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
196627000219	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
196627000220	putative active site [active]
196627000221	PhoH-like protein; Region: PhoH; pfam02562
196627000222	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
196627000223	Citrate transporter; Region: CitMHS; pfam03600
196627000224	H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620
196627000225	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
196627000226	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196627000227	ATP binding site [chemical binding]; other site
196627000228	Mg2+ binding site [ion binding]; other site
196627000229	G-X-G motif; other site
196627000230	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
196627000231	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196627000232	active site
196627000233	phosphorylation site [posttranslational modification]
196627000234	intermolecular recognition site; other site
196627000235	dimerization interface [polypeptide binding]; other site
196627000236	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
196627000237	putative DNA binding site [nucleotide binding]; other site
196627000238	putative Zn2+ binding site [ion binding]; other site
196627000239	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
196627000240	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159
196627000241	putative ligand binding site [chemical binding]; other site
196627000242	putative NAD binding site [chemical binding]; other site
196627000243	catalytic site [active]
196627000244	biotin synthase; Validated; Region: PRK06256
196627000245	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
196627000246	FeS/SAM binding site; other site
196627000247	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
196627000248	Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357
196627000249	CHY zinc finger; Region: zf-CHY; pfam05495
196627000250	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
196627000251	cytosine deaminase; Provisional; Region: PRK09230
196627000252	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
196627000253	active site
196627000254	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
196627000255	NAD-dependent deacetylase; Provisional; Region: PRK05333
196627000256	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
196627000257	Lipase (class 2); Region: Lipase_2; pfam01674
196627000258	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
196627000259	Lipase (class 2); Region: Lipase_2; pfam01674
196627000260	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
196627000261	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
196627000262	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
196627000263	alpha-gamma subunit interface [polypeptide binding]; other site
196627000264	beta-gamma subunit interface [polypeptide binding]; other site
196627000265	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
196627000266	gamma-beta subunit interface [polypeptide binding]; other site
196627000267	alpha-beta subunit interface [polypeptide binding]; other site
196627000268	urease subunit alpha; Reviewed; Region: ureC; PRK13207
196627000269	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
196627000270	subunit interactions [polypeptide binding]; other site
196627000271	active site
196627000272	flap region; other site
196627000273	Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371
196627000274	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
196627000275	dimer interface [polypeptide binding]; other site
196627000276	catalytic residues [active]
196627000277	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
196627000278	UreF; Region: UreF; pfam01730
196627000279	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
196627000280	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
196627000281	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
196627000282	HSP90 family protein; Provisional; Region: PRK14083
196627000283	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196627000284	ATP binding site [chemical binding]; other site
196627000285	Mg2+ binding site [ion binding]; other site
196627000286	G-X-G motif; other site
196627000287	AMP nucleosidase; Region: AMP-nucleosdse; TIGR01717
196627000288	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
196627000289	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
196627000290	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
196627000291	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
196627000292	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
196627000293	PYR/PP interface [polypeptide binding]; other site
196627000294	dimer interface [polypeptide binding]; other site
196627000295	TPP binding site [chemical binding]; other site
196627000296	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
196627000297	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
196627000298	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
196627000299	NAD(P) binding site [chemical binding]; other site
196627000300	catalytic residues [active]
196627000301	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
196627000302	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
196627000303	active site
196627000304	catalytic tetrad [active]
196627000305	Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978
196627000306	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
196627000307	amidohydrolase; Region: amidohydrolases; TIGR01891
196627000308	metal binding site [ion binding]; metal-binding site
196627000309	Predicted membrane protein [Function unknown]; Region: COG2149
196627000310	Domain of unknown function (DUF202); Region: DUF202; pfam02656
196627000311	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
196627000312	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
196627000313	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
196627000314	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
196627000315	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
196627000316	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
196627000317	catalytic core [active]
196627000318	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
196627000319	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
196627000320	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
196627000321	polyol permease family; Region: 2A0118; TIGR00897
196627000322	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627000323	putative substrate translocation pore; other site
196627000324	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
196627000325	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
196627000326	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
196627000327	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
196627000328	D-xylulose kinase; Region: XylB; TIGR01312
196627000329	nucleotide binding site [chemical binding]; other site
196627000330	Pantoate-beta-alanine ligase; Region: PanC; cd00560
196627000331	pantoate--beta-alanine ligase; Region: panC; TIGR00018
196627000332	active site
196627000333	ATP-binding site [chemical binding]; other site
196627000334	pantoate-binding site; other site
196627000335	HXXH motif; other site
196627000336	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
196627000337	oligomerization interface [polypeptide binding]; other site
196627000338	active site
196627000339	metal binding site [ion binding]; metal-binding site
196627000340	Fic family protein [Function unknown]; Region: COG3177
196627000341	Fic/DOC family; Region: Fic; pfam02661
196627000342	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
196627000343	active site
196627000344	DNA binding site [nucleotide binding]
196627000345	hypothetical protein; Provisional; Region: PRK07758
196627000346	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
196627000347	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
196627000348	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
196627000349	substrate binding pocket [chemical binding]; other site
196627000350	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
196627000351	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
196627000352	motif II; other site
196627000353	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
196627000354	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
196627000355	trimer interface [polypeptide binding]; other site
196627000356	putative metal binding site [ion binding]; other site
196627000357	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196627000358	putative DNA binding site [nucleotide binding]; other site
196627000359	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
196627000360	enterobactin exporter EntS; Provisional; Region: PRK10489
196627000361	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627000362	putative substrate translocation pore; other site
196627000363	BAX inhibitor (BI)-1 like protein family. Mammalian members of this family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well characterized oncogene, or...; Region: BI-1-like; cl00473
196627000364	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
196627000365	CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427
196627000366	DXD motif; other site
196627000367	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
196627000368	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
196627000369	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
196627000370	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
196627000371	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
196627000372	Predicted permeases [General function prediction only]; Region: RarD; COG2962
196627000373	Predicted membrane protein [Function unknown]; Region: COG2860
196627000374	UPF0126 domain; Region: UPF0126; pfam03458
196627000375	UPF0126 domain; Region: UPF0126; pfam03458
196627000376	Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187
196627000377	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
196627000378	tetramerization interface [polypeptide binding]; other site
196627000379	active site
196627000380	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805
196627000381	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
196627000382	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
196627000383	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
196627000384	hypothetical protein; Provisional; Region: PRK10621
196627000385	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
196627000386	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
196627000387	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196627000388	putative Mg++ binding site [ion binding]; other site
196627000389	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196627000390	nucleotide binding region [chemical binding]; other site
196627000391	ATP-binding site [chemical binding]; other site
196627000392	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
196627000393	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
196627000394	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
196627000395	maltose O-acetyltransferase; Provisional; Region: PRK10092
196627000396	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
196627000397	active site
196627000398	substrate binding site [chemical binding]; other site
196627000399	trimer interface [polypeptide binding]; other site
196627000400	CoA binding site [chemical binding]; other site
196627000401	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
196627000402	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
196627000403	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
196627000404	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
196627000405	RNA binding surface [nucleotide binding]; other site
196627000406	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
196627000407	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
196627000408	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
196627000409	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
196627000410	DNA binding site [nucleotide binding]
196627000411	active site
196627000412	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
196627000413	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
196627000414	homotrimer interaction site [polypeptide binding]; other site
196627000415	putative active site [active]
196627000416	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
196627000417	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
196627000418	active site
196627000419	Zn binding site [ion binding]; other site
196627000420	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
196627000421	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
196627000422	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
196627000423	DNA-binding site [nucleotide binding]; DNA binding site
196627000424	UTRA domain; Region: UTRA; pfam07702
196627000425	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
196627000426	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
196627000427	substrate binding site [chemical binding]; other site
196627000428	ATP binding site [chemical binding]; other site
196627000429	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
196627000430	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
196627000431	tetrameric interface [polypeptide binding]; other site
196627000432	NAD binding site [chemical binding]; other site
196627000433	catalytic residues [active]
196627000434	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
196627000435	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
196627000436	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
196627000437	PYR/PP interface [polypeptide binding]; other site
196627000438	dimer interface [polypeptide binding]; other site
196627000439	TPP binding site [chemical binding]; other site
196627000440	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
196627000441	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
196627000442	TPP-binding site; other site
196627000443	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
196627000444	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
196627000445	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
196627000446	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
196627000447	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
196627000448	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627000449	putative transporter; Provisional; Region: PRK10504
196627000450	putative substrate translocation pore; other site
196627000451	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
196627000452	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
196627000453	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
196627000454	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
196627000455	Transcriptional regulators [Transcription]; Region: PurR; COG1609
196627000456	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
196627000457	DNA binding site [nucleotide binding]
196627000458	domain linker motif; other site
196627000459	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
196627000460	dimerization interface [polypeptide binding]; other site
196627000461	ligand binding site [chemical binding]; other site
196627000462	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
196627000463	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
196627000464	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
196627000465	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
196627000466	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
196627000467	DNA-binding site [nucleotide binding]; DNA binding site
196627000468	RNA-binding motif; other site
196627000469	Transcriptional regulators [Transcription]; Region: MarR; COG1846
196627000470	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
196627000471	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
196627000472	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196627000473	S-adenosylmethionine binding site [chemical binding]; other site
196627000474	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
196627000475	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
196627000476	Coenzyme A binding pocket [chemical binding]; other site
196627000477	Transcriptional regulators [Transcription]; Region: PurR; COG1609
196627000478	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
196627000479	DNA binding site [nucleotide binding]
196627000480	domain linker motif; other site
196627000481	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
196627000482	dimerization interface [polypeptide binding]; other site
196627000483	ligand binding site [chemical binding]; other site
196627000484	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
196627000485	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627000486	putative substrate translocation pore; other site
196627000487	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627000488	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
196627000489	Helix-turn-helix domain; Region: HTH_38; pfam13936
196627000490	Homeodomain-like domain; Region: HTH_32; pfam13565
196627000491	Integrase core domain; Region: rve; pfam00665
196627000492	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
196627000493	PAS domain; Region: PAS_9; pfam13426
196627000494	putative active site [active]
196627000495	heme pocket [chemical binding]; other site
196627000496	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
196627000497	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
196627000498	active site
196627000499	dimer interface [polypeptide binding]; other site
196627000500	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
196627000501	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
196627000502	active site
196627000503	FMN binding site [chemical binding]; other site
196627000504	substrate binding site [chemical binding]; other site
196627000505	3Fe-4S cluster binding site [ion binding]; other site
196627000506	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
196627000507	domain interface; other site
196627000508	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
196627000509	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
196627000510	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
196627000511	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
196627000512	Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250
196627000513	Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249
196627000514	short chain dehydrogenase; Provisional; Region: PRK07904
196627000515	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
196627000516	NAD(P) binding site [chemical binding]; other site
196627000517	active site
196627000518	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
196627000519	FAD binding domain; Region: FAD_binding_4; pfam01565
196627000520	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
196627000521	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
196627000522	Predicted membrane protein [Function unknown]; Region: COG2246
196627000523	GtrA-like protein; Region: GtrA; pfam04138
196627000524	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
196627000525	MOSC domain; Region: MOSC; pfam03473
196627000526	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
196627000527	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
196627000528	active site
196627000529	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
196627000530	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
196627000531	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
196627000532	Walker A/P-loop; other site
196627000533	ATP binding site [chemical binding]; other site
196627000534	Q-loop/lid; other site
196627000535	ABC transporter signature motif; other site
196627000536	Walker B; other site
196627000537	D-loop; other site
196627000538	H-loop/switch region; other site
196627000539	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
196627000540	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
196627000541	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
196627000542	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
196627000543	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
196627000544	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
196627000545	NAD(P) binding site [chemical binding]; other site
196627000546	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
196627000547	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
196627000548	catalytic loop [active]
196627000549	iron binding site [ion binding]; other site
196627000550	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
196627000551	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
196627000552	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
196627000553	molybdopterin biosynthesis protein MoeB; Validated; Region: PRK05597
196627000554	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
196627000555	ATP binding site [chemical binding]; other site
196627000556	substrate interface [chemical binding]; other site
196627000557	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
196627000558	active site residue [active]
196627000559	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
196627000560	MoaE homodimer interface [polypeptide binding]; other site
196627000561	MoaD interaction [polypeptide binding]; other site
196627000562	active site residues [active]
196627000563	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
196627000564	MPT binding site; other site
196627000565	trimer interface [polypeptide binding]; other site
196627000566	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
196627000567	trimer interface [polypeptide binding]; other site
196627000568	dimer interface [polypeptide binding]; other site
196627000569	putative active site [active]
196627000570	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
196627000571	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
196627000572	dimer interface [polypeptide binding]; other site
196627000573	putative functional site; other site
196627000574	putative MPT binding site; other site
196627000575	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
196627000576	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196627000577	dimer interface [polypeptide binding]; other site
196627000578	conserved gate region; other site
196627000579	putative PBP binding loops; other site
196627000580	ABC-ATPase subunit interface; other site
196627000581	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
196627000582	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
196627000583	Ubiquitin-like proteins; Region: UBQ; cl00155
196627000584	charged pocket; other site
196627000585	hydrophobic patch; other site
196627000586	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
196627000587	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
196627000588	Walker A/P-loop; other site
196627000589	ATP binding site [chemical binding]; other site
196627000590	Q-loop/lid; other site
196627000591	ABC transporter signature motif; other site
196627000592	Walker B; other site
196627000593	D-loop; other site
196627000594	H-loop/switch region; other site
196627000595	Predicted membrane protein [Function unknown]; Region: COG1950
196627000596	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
196627000597	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
196627000598	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196627000599	homodimer interface [polypeptide binding]; other site
196627000600	catalytic residue [active]
196627000601	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
196627000602	Transcriptional regulator [Transcription]; Region: LysR; COG0583
196627000603	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
196627000604	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
196627000605	dimerization interface [polypeptide binding]; other site
196627000606	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
196627000607	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296
196627000608	putative NAD(P) binding site [chemical binding]; other site
196627000609	putative substrate binding site [chemical binding]; other site
196627000610	catalytic Zn binding site [ion binding]; other site
196627000611	structural Zn binding site [ion binding]; other site
196627000612	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
196627000613	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
196627000614	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
196627000615	MgtE intracellular N domain; Region: MgtE_N; smart00924
196627000616	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
196627000617	Divalent cation transporter; Region: MgtE; cl00786
196627000618	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
196627000619	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
196627000620	transmembrane helices; other site
196627000621	prephenate dehydrogenase; Validated; Region: PRK06545
196627000622	prephenate dehydrogenase; Validated; Region: PRK08507
196627000623	putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941
196627000624	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
196627000625	nucleoside/Zn binding site; other site
196627000626	dimer interface [polypeptide binding]; other site
196627000627	catalytic motif [active]
196627000628	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
196627000629	MMPL family; Region: MMPL; pfam03176
196627000630	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
196627000631	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
196627000632	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
196627000633	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
196627000634	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
196627000635	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196627000636	Q-loop/lid; other site
196627000637	ABC transporter signature motif; other site
196627000638	Walker B; other site
196627000639	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
196627000640	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
196627000641	active site
196627000642	HIGH motif; other site
196627000643	nucleotide binding site [chemical binding]; other site
196627000644	active site
196627000645	KMSKS motif; other site
196627000646	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
196627000647	Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to  the...; Region: intradiol_dioxygenase_like; cd03457
196627000648	putative active site [active]
196627000649	Integrase core domain; Region: rve; pfam00665
196627000650	DDE domain; Region: DDE_Tnp_IS240; pfam13610
196627000651	Integrase core domain; Region: rve_3; pfam13683
196627000652	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
196627000653	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
196627000654	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196627000655	homodimer interface [polypeptide binding]; other site
196627000656	catalytic residue [active]
196627000657	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
196627000658	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
196627000659	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196627000660	Walker A motif; other site
196627000661	ATP binding site [chemical binding]; other site
196627000662	Walker B motif; other site
196627000663	arginine finger; other site
196627000664	hypothetical protein; Validated; Region: PRK00153
196627000665	recombination protein RecR; Reviewed; Region: recR; PRK00076
196627000666	Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278
196627000667	RecR protein; Region: RecR; pfam02132
196627000668	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
196627000669	putative active site [active]
196627000670	putative metal-binding site [ion binding]; other site
196627000671	tetramer interface [polypeptide binding]; other site
196627000672	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
196627000673	catalytic triad [active]
196627000674	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
196627000675	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
196627000676	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
196627000677	DNA polymerase III subunit epsilon; Validated; Region: PRK05601
196627000678	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
196627000679	2-isopropylmalate synthase; Validated; Region: PRK03739
196627000680	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
196627000681	active site
196627000682	catalytic residues [active]
196627000683	metal binding site [ion binding]; metal-binding site
196627000684	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
196627000685	aspartate kinase; Reviewed; Region: PRK06635
196627000686	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
196627000687	putative nucleotide binding site [chemical binding]; other site
196627000688	putative catalytic residues [active]
196627000689	putative Mg ion binding site [ion binding]; other site
196627000690	putative aspartate binding site [chemical binding]; other site
196627000691	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
196627000692	putative allosteric regulatory site; other site
196627000693	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
196627000694	putative allosteric regulatory residue; other site
196627000695	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
196627000696	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
196627000697	RNA polymerase sigma factor; Provisional; Region: PRK12535
196627000698	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
196627000699	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196627000700	DNA binding residues [nucleotide binding]
196627000701	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
196627000702	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
196627000703	heme binding pocket [chemical binding]; other site
196627000704	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
196627000705	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
196627000706	AsnC family; Region: AsnC_trans_reg; pfam01037
196627000707	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
196627000708	Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687
196627000709	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196627000710	dimerization interface [polypeptide binding]; other site
196627000711	putative DNA binding site [nucleotide binding]; other site
196627000712	putative Zn2+ binding site [ion binding]; other site
196627000713	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
196627000714	arsenical-resistance protein; Region: acr3; TIGR00832
196627000715	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
196627000716	Low molecular weight phosphatase family; Region: LMWPc; cl00105
196627000717	active site
196627000718	Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism]; Region: MnhG; COG1320
196627000719	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612
196627000720	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654
196627000721	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
196627000722	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
196627000723	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375
196627000724	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650
196627000725	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
196627000726	Domain of unknown function (DUF4040); Region: DUF4040; pfam13244
196627000727	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
196627000728	Predicted membrane protein [Function unknown]; Region: COG1511
196627000729	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
196627000730	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
196627000731	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196627000732	active site
196627000733	phosphorylation site [posttranslational modification]
196627000734	intermolecular recognition site; other site
196627000735	dimerization interface [polypeptide binding]; other site
196627000736	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
196627000737	DNA binding site [nucleotide binding]
196627000738	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
196627000739	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
196627000740	dimerization interface [polypeptide binding]; other site
196627000741	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196627000742	dimer interface [polypeptide binding]; other site
196627000743	phosphorylation site [posttranslational modification]
196627000744	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196627000745	ATP binding site [chemical binding]; other site
196627000746	Mg2+ binding site [ion binding]; other site
196627000747	G-X-G motif; other site
196627000748	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
196627000749	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
196627000750	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
196627000751	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
196627000752	putative active site [active]
196627000753	putative metal binding site [ion binding]; other site
196627000754	Yqey-like protein; Region: YqeY; pfam09424
196627000755	Transglycosylase; Region: Transgly; pfam00912
196627000756	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
196627000757	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
196627000758	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
196627000759	Transcription factor WhiB; Region: Whib; pfam02467
196627000760	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
196627000761	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
196627000762	homotrimer interaction site [polypeptide binding]; other site
196627000763	putative active site [active]
196627000764	metabolite-proton symporter; Region: 2A0106; TIGR00883
196627000765	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627000766	putative substrate translocation pore; other site
196627000767	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
196627000768	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
196627000769	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
196627000770	acyl-activating enzyme (AAE) consensus motif; other site
196627000771	acyl-activating enzyme (AAE) consensus motif; other site
196627000772	putative AMP binding site [chemical binding]; other site
196627000773	putative active site [active]
196627000774	putative CoA binding site [chemical binding]; other site
196627000775	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
196627000776	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
196627000777	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
196627000778	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196627000779	NAD(P) binding site [chemical binding]; other site
196627000780	active site
196627000781	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
196627000782	active site
196627000783	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196627000784	acyl-coenzyme A oxidase; Region: PLN02526
196627000785	active site
196627000786	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
196627000787	putative active site [active]
196627000788	putative catalytic site [active]
196627000789	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
196627000790	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
196627000791	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
196627000792	ligand binding site [chemical binding]; other site
196627000793	flexible hinge region; other site
196627000794	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
196627000795	putative switch regulator; other site
196627000796	non-specific DNA interactions [nucleotide binding]; other site
196627000797	DNA binding site [nucleotide binding]
196627000798	sequence specific DNA binding site [nucleotide binding]; other site
196627000799	putative cAMP binding site [chemical binding]; other site
196627000800	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
196627000801	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
196627000802	minor groove reading motif; other site
196627000803	helix-hairpin-helix signature motif; other site
196627000804	substrate binding pocket [chemical binding]; other site
196627000805	active site
196627000806	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
196627000807	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
196627000808	catalytic residues [active]
196627000809	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
196627000810	putative active site [active]
196627000811	putative CoA binding site [chemical binding]; other site
196627000812	nudix motif; other site
196627000813	metal binding site [ion binding]; metal-binding site
196627000814	Colicin V production protein; Region: Colicin_V; pfam02674
196627000815	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
196627000816	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
196627000817	active site
196627000818	substrate binding sites [chemical binding]; other site
196627000819	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
196627000820	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
196627000821	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
196627000822	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
196627000823	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
196627000824	motif II; other site
196627000825	helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815
196627000826	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
196627000827	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
196627000828	ATP binding site [chemical binding]; other site
196627000829	Walker A motif; other site
196627000830	hexamer interface [polypeptide binding]; other site
196627000831	Walker B motif; other site
196627000832	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
196627000833	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
196627000834	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
196627000835	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
196627000836	Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
196627000837	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
196627000838	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196627000839	ATP binding site [chemical binding]; other site
196627000840	putative Mg++ binding site [ion binding]; other site
196627000841	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
196627000842	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
196627000843	DNA-binding site [nucleotide binding]; DNA binding site
196627000844	RNA-binding motif; other site
196627000845	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
196627000846	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
196627000847	active site
196627000848	interdomain interaction site; other site
196627000849	putative metal-binding site [ion binding]; other site
196627000850	nucleotide binding site [chemical binding]; other site
196627000851	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
196627000852	domain I; other site
196627000853	DNA binding groove [nucleotide binding]
196627000854	phosphate binding site [ion binding]; other site
196627000855	domain II; other site
196627000856	domain III; other site
196627000857	nucleotide binding site [chemical binding]; other site
196627000858	catalytic site [active]
196627000859	domain IV; other site
196627000860	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
196627000861	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
196627000862	YhhN-like protein; Region: YhhN; pfam07947
196627000863	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
196627000864	dimerization interface [polypeptide binding]; other site
196627000865	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
196627000866	cyclase homology domain; Region: CHD; cd07302
196627000867	nucleotidyl binding site; other site
196627000868	metal binding site [ion binding]; metal-binding site
196627000869	dimer interface [polypeptide binding]; other site
196627000870	DNA polymerase III subunit delta'; Validated; Region: PRK07940
196627000871	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
196627000872	Walker A motif; other site
196627000873	ATP binding site [chemical binding]; other site
196627000874	Walker B motif; other site
196627000875	arginine finger; other site
196627000876	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
196627000877	Uncharacterized phage-associated protein [Function unknown]; Region: GepA; COG3600
196627000878	Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563
196627000879	AAA domain; Region: AAA_17; pfam13207
196627000880	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
196627000881	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
196627000882	RNA binding surface [nucleotide binding]; other site
196627000883	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
196627000884	active site
196627000885	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
196627000886	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
196627000887	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
196627000888	S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451
196627000889	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
196627000890	NAD binding site [chemical binding]; other site
196627000891	catalytic Zn binding site [ion binding]; other site
196627000892	substrate binding site [chemical binding]; other site
196627000893	structural Zn binding site [ion binding]; other site
196627000894	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
196627000895	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
196627000896	classical (c) SDRs; Region: SDR_c; cd05233
196627000897	NAD(P) binding site [chemical binding]; other site
196627000898	active site
196627000899	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627000900	Major Facilitator Superfamily; Region: MFS_1; pfam07690
196627000901	putative substrate translocation pore; other site
196627000902	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
196627000903	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196627000904	NAD(P) binding site [chemical binding]; other site
196627000905	active site
196627000906	Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034
196627000907	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
196627000908	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
196627000909	Ligand binding site; other site
196627000910	Putative Catalytic site; other site
196627000911	DXD motif; other site
196627000912	Ribonuclease HI [DNA replication, recombination, and repair]; Region: RnhA; COG0328
196627000913	RNA/DNA hybrid binding site [nucleotide binding]; other site
196627000914	active site
196627000915	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
196627000916	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
196627000917	Probable Catalytic site; other site
196627000918	metal-binding site
196627000919	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
196627000920	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
196627000921	putative active site [active]
196627000922	putative metal binding site [ion binding]; other site
196627000923	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
196627000924	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
196627000925	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
196627000926	putative NAD(P) binding site [chemical binding]; other site
196627000927	putative substrate binding site [chemical binding]; other site
196627000928	catalytic Zn binding site [ion binding]; other site
196627000929	structural Zn binding site [ion binding]; other site
196627000930	dimer interface [polypeptide binding]; other site
196627000931	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
196627000932	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
196627000933	substrate binding site; other site
196627000934	tetramer interface; other site
196627000935	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
196627000936	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
196627000937	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
196627000938	NADP binding site [chemical binding]; other site
196627000939	active site
196627000940	putative substrate binding site [chemical binding]; other site
196627000941	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
196627000942	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
196627000943	NAD binding site [chemical binding]; other site
196627000944	substrate binding site [chemical binding]; other site
196627000945	homodimer interface [polypeptide binding]; other site
196627000946	active site
196627000947	NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370
196627000948	dimer interface [polypeptide binding]; other site
196627000949	FMN binding site [chemical binding]; other site
196627000950	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
196627000951	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
196627000952	siderophore binding site; other site
196627000953	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
196627000954	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
196627000955	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
196627000956	Zn binding site [ion binding]; other site
196627000957	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
196627000958	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
196627000959	Excalibur calcium-binding domain; Region: Excalibur; smart00894
196627000960	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
196627000961	Predicted esterase [General function prediction only]; Region: COG0627
196627000962	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
196627000963	Chain length determinant protein; Region: Wzz; cl15801
196627000964	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
196627000965	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
196627000966	Low molecular weight phosphatase family; Region: LMWPc; cl00105
196627000967	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
196627000968	active site
196627000969	VPS10 domain; Region: VPS10; smart00602
196627000970	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
196627000971	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
196627000972	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
196627000973	NAD(P) binding site [chemical binding]; other site
196627000974	homodimer interface [polypeptide binding]; other site
196627000975	substrate binding site [chemical binding]; other site
196627000976	active site
196627000977	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
196627000978	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
196627000979	inhibitor-cofactor binding pocket; inhibition site
196627000980	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196627000981	catalytic residue [active]
196627000982	Bacterial sugar transferase; Region: Bac_transf; pfam02397
196627000983	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
196627000984	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
196627000985	putative ADP-binding pocket [chemical binding]; other site
196627000986	colanic acid exporter; Provisional; Region: PRK10459
196627000987	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
196627000988	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
196627000989	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
196627000990	hinge; other site
196627000991	active site
196627000992	UDP-N-acetylmuramate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: MurB; COG0812
196627000993	FAD binding domain; Region: FAD_binding_4; pfam01565
196627000994	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
196627000995	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
196627000996	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
196627000997	active site
196627000998	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
196627000999	Transposase; Region: DDE_Tnp_ISL3; pfam01610
196627001000	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
196627001001	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
196627001002	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
196627001003	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
196627001004	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
196627001005	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
196627001006	O-Antigen ligase; Region: Wzy_C; pfam04932
196627001007	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
196627001008	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
196627001009	active site
196627001010	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
196627001011	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
196627001012	putative trimer interface [polypeptide binding]; other site
196627001013	putative CoA binding site [chemical binding]; other site
196627001014	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818
196627001015	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
196627001016	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
196627001017	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
196627001018	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
196627001019	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
196627001020	active site
196627001021	tetramer interface; other site
196627001022	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
196627001023	putative deacylase active site [active]
196627001024	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
196627001025	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
196627001026	non-specific DNA binding site [nucleotide binding]; other site
196627001027	salt bridge; other site
196627001028	sequence-specific DNA binding site [nucleotide binding]; other site
196627001029	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
196627001030	Domain of unknown function (DUF955); Region: DUF955; pfam06114
196627001031	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
196627001032	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
196627001033	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
196627001034	putative Iron-sulfur protein interface [polypeptide binding]; other site
196627001035	proximal heme binding site [chemical binding]; other site
196627001036	distal heme binding site [chemical binding]; other site
196627001037	putative dimer interface [polypeptide binding]; other site
196627001038	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
196627001039	L-aspartate oxidase; Provisional; Region: PRK06175
196627001040	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
196627001041	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
196627001042	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
196627001043	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
196627001044	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
196627001045	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
196627001046	Predicted membrane protein [Function unknown]; Region: COG2733
196627001047	Protein of unknown function (DUF2516); Region: DUF2516; pfam10724
196627001048	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196627001049	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196627001050	Major Facilitator Superfamily; Region: MFS_1; pfam07690
196627001051	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627001052	putative substrate translocation pore; other site
196627001053	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627001054	putative substrate translocation pore; other site
196627001055	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627001056	Major Facilitator Superfamily; Region: MFS_1; pfam07690
196627001057	putative substrate translocation pore; other site
196627001058	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
196627001059	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
196627001060	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
196627001061	putative active site [active]
196627001062	putative substrate binding site [chemical binding]; other site
196627001063	putative cosubstrate binding site; other site
196627001064	catalytic site [active]
196627001065	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
196627001066	intersubunit interface [polypeptide binding]; other site
196627001067	active site
196627001068	catalytic residue [active]
196627001069	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
196627001070	putative homodimer interface [polypeptide binding]; other site
196627001071	putative homotetramer interface [polypeptide binding]; other site
196627001072	putative allosteric switch controlling residues; other site
196627001073	putative metal binding site [ion binding]; other site
196627001074	putative homodimer-homodimer interface [polypeptide binding]; other site
196627001075	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
196627001076	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
196627001077	metal-binding site [ion binding]
196627001078	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
196627001079	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
196627001080	Htaa; Region: HtaA; pfam04213
196627001081	Htaa; Region: HtaA; pfam04213
196627001082	ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558
196627001083	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
196627001084	intersubunit interface [polypeptide binding]; other site
196627001085	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
196627001086	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
196627001087	dimer interface [polypeptide binding]; other site
196627001088	putative PBP binding regions; other site
196627001089	ABC-ATPase subunit  interface; other site
196627001090	ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559
196627001091	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
196627001092	Walker A/P-loop; other site
196627001093	ATP binding site [chemical binding]; other site
196627001094	Q-loop/lid; other site
196627001095	ABC transporter signature motif; other site
196627001096	Walker B; other site
196627001097	D-loop; other site
196627001098	H-loop/switch region; other site
196627001099	Htaa; Region: HtaA; pfam04213
196627001100	Htaa; Region: HtaA; pfam04213
196627001101	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
196627001102	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
196627001103	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
196627001104	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
196627001105	FAD binding domain; Region: FAD_binding_4; pfam01565
196627001106	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
196627001107	hypothetical protein; Provisional; Region: PRK07758
196627001108	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
196627001109	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605
196627001110	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
196627001111	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
196627001112	acyl-activating enzyme (AAE) consensus motif; other site
196627001113	AMP binding site [chemical binding]; other site
196627001114	active site
196627001115	CoA binding site [chemical binding]; other site
196627001116	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
196627001117	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
196627001118	putative ADP-binding pocket [chemical binding]; other site
196627001119	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
196627001120	catalytic core [active]
196627001121	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
196627001122	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
196627001123	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196627001124	dimer interface [polypeptide binding]; other site
196627001125	phosphorylation site [posttranslational modification]
196627001126	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196627001127	ATP binding site [chemical binding]; other site
196627001128	Mg2+ binding site [ion binding]; other site
196627001129	G-X-G motif; other site
196627001130	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
196627001131	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196627001132	active site
196627001133	phosphorylation site [posttranslational modification]
196627001134	intermolecular recognition site; other site
196627001135	dimerization interface [polypeptide binding]; other site
196627001136	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
196627001137	DNA binding site [nucleotide binding]
196627001138	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
196627001139	FtsX-like permease family; Region: FtsX; pfam02687
196627001140	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
196627001141	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
196627001142	FtsX-like permease family; Region: FtsX; pfam02687
196627001143	exopolyphosphatase; Region: exo_poly_only; TIGR03706
196627001144	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
196627001145	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
196627001146	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
196627001147	DNA binding domain, excisionase family; Region: excise; TIGR01764
196627001148	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
196627001149	HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1
196627001150	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
196627001151	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
196627001152	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
196627001153	tRNA; other site
196627001154	putative tRNA binding site [nucleotide binding]; other site
196627001155	putative NADP binding site [chemical binding]; other site
196627001156	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
196627001157	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
196627001158	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
196627001159	domain interfaces; other site
196627001160	active site
196627001161	Transcriptional regulator [Transcription]; Region: LysR; COG0583
196627001162	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
196627001163	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
196627001164	dimerization interface [polypeptide binding]; other site
196627001165	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627001166	metabolite-proton symporter; Region: 2A0106; TIGR00883
196627001167	putative substrate translocation pore; other site
196627001168	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
196627001169	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
196627001170	AP (apurinic/apyrimidinic) site pocket; other site
196627001171	DNA interaction; other site
196627001172	Metal-binding active site; metal-binding site
196627001173	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
196627001174	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
196627001175	active site
196627001176	metal binding site [ion binding]; metal-binding site
196627001177	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
196627001178	active site
196627001179	Fe binding site [ion binding]; other site
196627001180	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
196627001181	Dehydroquinase class II; Region: DHquinase_II; pfam01220
196627001182	active site
196627001183	trimer interface [polypeptide binding]; other site
196627001184	dimer interface [polypeptide binding]; other site
196627001185	quinate/shikimate dehydrogenase; Provisional; Region: PRK14027
196627001186	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
196627001187	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
196627001188	shikimate binding site; other site
196627001189	NAD(P) binding site [chemical binding]; other site
196627001190	Ribosomal protein L7/L12 [Translation, ribosomal structure and biogenesis]; Region: RplL; COG0222
196627001191	L11 interface [polypeptide binding]; other site
196627001192	putative EF-Tu interaction site [polypeptide binding]; other site
196627001193	putative EF-G interaction site [polypeptide binding]; other site
196627001194	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
196627001195	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
196627001196	Walker A/P-loop; other site
196627001197	ATP binding site [chemical binding]; other site
196627001198	Q-loop/lid; other site
196627001199	ABC transporter signature motif; other site
196627001200	Walker B; other site
196627001201	D-loop; other site
196627001202	H-loop/switch region; other site
196627001203	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
196627001204	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196627001205	dimer interface [polypeptide binding]; other site
196627001206	conserved gate region; other site
196627001207	putative PBP binding loops; other site
196627001208	ABC-ATPase subunit interface; other site
196627001209	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
196627001210	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
196627001211	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
196627001212	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815
196627001213	active site
196627001214	homodimer interface [polypeptide binding]; other site
196627001215	SAM binding site [chemical binding]; other site
196627001216	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
196627001217	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
196627001218	active site
196627001219	Domain of unknown function (DUF3806); Region: DUF3806; pfam12713
196627001220	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
196627001221	dimer interface [polypeptide binding]; other site
196627001222	active site
196627001223	Schiff base residues; other site
196627001224	Prokaryotic cytochrome b561; Region: Ni_hydr_CYTB; cl00859
196627001225	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
196627001226	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
196627001227	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
196627001228	substrate binding site [chemical binding]; other site
196627001229	active site
196627001230	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
196627001231	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
196627001232	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
196627001233	inhibitor-cofactor binding pocket; inhibition site
196627001234	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196627001235	catalytic residue [active]
196627001236	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
196627001237	catalytic core [active]
196627001238	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
196627001239	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
196627001240	catalytic residues [active]
196627001241	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
196627001242	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
196627001243	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333
196627001244	ResB-like family; Region: ResB; pfam05140
196627001245	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
196627001246	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
196627001247	active site
196627001248	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
196627001249	homotrimer interaction site [polypeptide binding]; other site
196627001250	putative active site [active]
196627001251	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196627001252	putative DNA binding site [nucleotide binding]; other site
196627001253	dimerization interface [polypeptide binding]; other site
196627001254	putative Zn2+ binding site [ion binding]; other site
196627001255	Protein of unknown function (DUF4229); Region: DUF4229; pfam14012
196627001256	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
196627001257	UbiA prenyltransferase family; Region: UbiA; pfam01040
196627001258	acetolactate synthase catalytic subunit; Validated; Region: PRK08327
196627001259	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824
196627001260	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
196627001261	acyl-activating enzyme (AAE) consensus motif; other site
196627001262	AMP binding site [chemical binding]; other site
196627001263	active site
196627001264	CoA binding site [chemical binding]; other site
196627001265	Predicted membrane protein [Function unknown]; Region: COG2259
196627001266	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
196627001267	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
196627001268	dimer interface [polypeptide binding]; other site
196627001269	NADP binding site [chemical binding]; other site
196627001270	catalytic residues [active]
196627001271	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
196627001272	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
196627001273	putative active site [active]
196627001274	catalytic residue [active]
196627001275	Transcriptional regulator [Transcription]; Region: LysR; COG0583
196627001276	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
196627001277	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447
196627001278	putative dimerization interface [polypeptide binding]; other site
196627001279	putative substrate binding pocket [chemical binding]; other site
196627001280	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
196627001281	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
196627001282	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
196627001283	active site
196627001284	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
196627001285	active site 1 [active]
196627001286	active site 2 [active]
196627001287	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
196627001288	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
196627001289	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
196627001290	substrate binding site [chemical binding]; other site
196627001291	oxyanion hole (OAH) forming residues; other site
196627001292	trimer interface [polypeptide binding]; other site
196627001293	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
196627001294	aromatic arch; other site
196627001295	DCoH dimer interaction site [polypeptide binding]; other site
196627001296	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
196627001297	DCoH tetramer interaction site [polypeptide binding]; other site
196627001298	substrate binding site [chemical binding]; other site
196627001299	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129
196627001300	catalytic triad [active]
196627001301	active site nucleophile [active]
196627001302	O-succinylbenzoate synthase; Provisional; Region: PRK02901
196627001303	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
196627001304	active site
196627001305	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165
196627001306	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
196627001307	dimer interface [polypeptide binding]; other site
196627001308	tetramer interface [polypeptide binding]; other site
196627001309	PYR/PP interface [polypeptide binding]; other site
196627001310	TPP binding site [chemical binding]; other site
196627001311	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
196627001312	TPP-binding site; other site
196627001313	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
196627001314	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
196627001315	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
196627001316	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
196627001317	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196627001318	S-adenosylmethionine binding site [chemical binding]; other site
196627001319	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
196627001320	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
196627001321	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
196627001322	substrate binding pocket [chemical binding]; other site
196627001323	chain length determination region; other site
196627001324	substrate-Mg2+ binding site; other site
196627001325	catalytic residues [active]
196627001326	aspartate-rich region 1; other site
196627001327	active site lid residues [active]
196627001328	aspartate-rich region 2; other site
196627001329	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
196627001330	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
196627001331	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
196627001332	putative homodimer interface [polypeptide binding]; other site
196627001333	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
196627001334	heterodimer interface [polypeptide binding]; other site
196627001335	homodimer interface [polypeptide binding]; other site
196627001336	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
196627001337	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
196627001338	23S rRNA interface [nucleotide binding]; other site
196627001339	L7/L12 interface [polypeptide binding]; other site
196627001340	putative thiostrepton binding site; other site
196627001341	L25 interface [polypeptide binding]; other site
196627001342	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
196627001343	mRNA/rRNA interface [nucleotide binding]; other site
196627001344	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
196627001345	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
196627001346	4-aminobutyrate aminotransferase; Provisional; Region: PRK06058
196627001347	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
196627001348	inhibitor-cofactor binding pocket; inhibition site
196627001349	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196627001350	catalytic residue [active]
196627001351	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
196627001352	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
196627001353	tetramerization interface [polypeptide binding]; other site
196627001354	NAD(P) binding site [chemical binding]; other site
196627001355	catalytic residues [active]
196627001356	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
196627001357	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
196627001358	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
196627001359	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
196627001360	Soluble P-type ATPase [General function prediction only]; Region: COG4087
196627001361	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
196627001362	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
196627001363	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
196627001364	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
196627001365	23S rRNA interface [nucleotide binding]; other site
196627001366	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
196627001367	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
196627001368	core dimer interface [polypeptide binding]; other site
196627001369	peripheral dimer interface [polypeptide binding]; other site
196627001370	L10 interface [polypeptide binding]; other site
196627001371	L11 interface [polypeptide binding]; other site
196627001372	putative EF-Tu interaction site [polypeptide binding]; other site
196627001373	putative EF-G interaction site [polypeptide binding]; other site
196627001374	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
196627001375	Tetraspanin family; Region: Tetraspannin; pfam00335
196627001376	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
196627001377	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
196627001378	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
196627001379	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
196627001380	RPB1 interaction site [polypeptide binding]; other site
196627001381	RPB10 interaction site [polypeptide binding]; other site
196627001382	RPB11 interaction site [polypeptide binding]; other site
196627001383	RPB3 interaction site [polypeptide binding]; other site
196627001384	RPB12 interaction site [polypeptide binding]; other site
196627001385	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
196627001386	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
196627001387	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
196627001388	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
196627001389	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
196627001390	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
196627001391	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
196627001392	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
196627001393	G-loop; other site
196627001394	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
196627001395	DNA binding site [nucleotide binding]
196627001396	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
196627001397	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
196627001398	salt bridge; other site
196627001399	non-specific DNA binding site [nucleotide binding]; other site
196627001400	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
196627001401	sequence-specific DNA binding site [nucleotide binding]; other site
196627001402	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
196627001403	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
196627001404	S17 interaction site [polypeptide binding]; other site
196627001405	S8 interaction site; other site
196627001406	16S rRNA interaction site [nucleotide binding]; other site
196627001407	streptomycin interaction site [chemical binding]; other site
196627001408	23S rRNA interaction site [nucleotide binding]; other site
196627001409	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
196627001410	30S ribosomal protein S7; Validated; Region: PRK05302
196627001411	elongation factor G; Reviewed; Region: PRK00007
196627001412	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
196627001413	G1 box; other site
196627001414	putative GEF interaction site [polypeptide binding]; other site
196627001415	GTP/Mg2+ binding site [chemical binding]; other site
196627001416	Switch I region; other site
196627001417	G2 box; other site
196627001418	G3 box; other site
196627001419	Switch II region; other site
196627001420	G4 box; other site
196627001421	G5 box; other site
196627001422	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
196627001423	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
196627001424	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
196627001425	elongation factor Tu; Reviewed; Region: PRK00049
196627001426	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
196627001427	G1 box; other site
196627001428	GEF interaction site [polypeptide binding]; other site
196627001429	GTP/Mg2+ binding site [chemical binding]; other site
196627001430	Switch I region; other site
196627001431	G2 box; other site
196627001432	G3 box; other site
196627001433	Switch II region; other site
196627001434	G4 box; other site
196627001435	G5 box; other site
196627001436	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
196627001437	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
196627001438	Antibiotic Binding Site [chemical binding]; other site
196627001439	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
196627001440	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
196627001441	Walker A/P-loop; other site
196627001442	ATP binding site [chemical binding]; other site
196627001443	Q-loop/lid; other site
196627001444	ABC transporter signature motif; other site
196627001445	Walker B; other site
196627001446	D-loop; other site
196627001447	H-loop/switch region; other site
196627001448	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
196627001449	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
196627001450	ABC-ATPase subunit  interface; other site
196627001451	dimer interface [polypeptide binding]; other site
196627001452	putative PBP binding regions; other site
196627001453	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
196627001454	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
196627001455	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
196627001456	ABC-ATPase subunit  interface; other site
196627001457	dimer interface [polypeptide binding]; other site
196627001458	putative PBP binding regions; other site
196627001459	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
196627001460	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
196627001461	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
196627001462	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
196627001463	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
196627001464	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
196627001465	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
196627001466	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
196627001467	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
196627001468	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
196627001469	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
196627001470	putative translocon binding site; other site
196627001471	protein-rRNA interface [nucleotide binding]; other site
196627001472	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
196627001473	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
196627001474	G-X-X-G motif; other site
196627001475	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
196627001476	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
196627001477	23S rRNA interface [nucleotide binding]; other site
196627001478	5S rRNA interface [nucleotide binding]; other site
196627001479	putative antibiotic binding site [chemical binding]; other site
196627001480	L25 interface [polypeptide binding]; other site
196627001481	L27 interface [polypeptide binding]; other site
196627001482	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
196627001483	putative translocon interaction site; other site
196627001484	23S rRNA interface [nucleotide binding]; other site
196627001485	signal recognition particle (SRP54) interaction site; other site
196627001486	L23 interface [polypeptide binding]; other site
196627001487	trigger factor interaction site; other site
196627001488	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
196627001489	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
196627001490	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
196627001491	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
196627001492	RNA binding site [nucleotide binding]; other site
196627001493	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
196627001494	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
196627001495	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
196627001496	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
196627001497	active site
196627001498	catalytic triad [active]
196627001499	oxyanion hole [active]
196627001500	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
196627001501	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
196627001502	active site
196627001503	catalytic tetrad [active]
196627001504	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
196627001505	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
196627001506	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
196627001507	putative molybdopterin cofactor binding site [chemical binding]; other site
196627001508	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
196627001509	putative molybdopterin cofactor binding site; other site
196627001510	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
196627001511	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
196627001512	Walker A/P-loop; other site
196627001513	ATP binding site [chemical binding]; other site
196627001514	Q-loop/lid; other site
196627001515	ABC transporter signature motif; other site
196627001516	Walker B; other site
196627001517	D-loop; other site
196627001518	H-loop/switch region; other site
196627001519	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
196627001520	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196627001521	Walker A/P-loop; other site
196627001522	ATP binding site [chemical binding]; other site
196627001523	Q-loop/lid; other site
196627001524	ABC transporter signature motif; other site
196627001525	Walker B; other site
196627001526	D-loop; other site
196627001527	H-loop/switch region; other site
196627001528	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
196627001529	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
196627001530	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
196627001531	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
196627001532	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
196627001533	Coenzyme A binding pocket [chemical binding]; other site
196627001534	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
196627001535	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
196627001536	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
196627001537	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
196627001538	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
196627001539	5S rRNA interface [nucleotide binding]; other site
196627001540	L27 interface [polypeptide binding]; other site
196627001541	23S rRNA interface [nucleotide binding]; other site
196627001542	L5 interface [polypeptide binding]; other site
196627001543	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
196627001544	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
196627001545	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
196627001546	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
196627001547	23S rRNA binding site [nucleotide binding]; other site
196627001548	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
196627001549	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
196627001550	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
196627001551	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
196627001552	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
196627001553	NAD binding site [chemical binding]; other site
196627001554	catalytic residues [active]
196627001555	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
196627001556	Zn2+ binding site [ion binding]; other site
196627001557	Mg2+ binding site [ion binding]; other site
196627001558	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
196627001559	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
196627001560	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
196627001561	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
196627001562	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
196627001563	catalytic loop [active]
196627001564	iron binding site [ion binding]; other site
196627001565	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
196627001566	classical (c) SDRs; Region: SDR_c; cd05233
196627001567	NAD(P) binding site [chemical binding]; other site
196627001568	active site
196627001569	hypothetical protein; Provisional; Region: PRK08296
196627001570	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
196627001571	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
196627001572	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
196627001573	Cytochrome P450; Region: p450; cl12078
196627001574	Transcriptional regulator [Transcription]; Region: IclR; COG1414
196627001575	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
196627001576	Bacterial transcriptional regulator; Region: IclR; pfam01614
196627001577	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
196627001578	SecY translocase; Region: SecY; pfam00344
196627001579	adenylate kinase; Reviewed; Region: adk; PRK00279
196627001580	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
196627001581	AMP-binding site [chemical binding]; other site
196627001582	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
196627001583	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
196627001584	active site
196627001585	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
196627001586	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
196627001587	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
196627001588	rRNA binding site [nucleotide binding]; other site
196627001589	predicted 30S ribosome binding site; other site
196627001590	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
196627001591	30S ribosomal protein S13; Region: bact_S13; TIGR03631
196627001592	30S ribosomal protein S11; Validated; Region: PRK05309
196627001593	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
196627001594	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
196627001595	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
196627001596	RNA binding surface [nucleotide binding]; other site
196627001597	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
196627001598	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
196627001599	alphaNTD - beta interaction site [polypeptide binding]; other site
196627001600	alphaNTD homodimer interface [polypeptide binding]; other site
196627001601	alphaNTD - beta' interaction site [polypeptide binding]; other site
196627001602	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
196627001603	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
196627001604	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
196627001605	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
196627001606	dimerization interface 3.5A [polypeptide binding]; other site
196627001607	active site
196627001608	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
196627001609	Coenzyme A binding pocket [chemical binding]; other site
196627001610	type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919
196627001611	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
196627001612	FAD binding domain; Region: FAD_binding_4; pfam01565
196627001613	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
196627001614	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
196627001615	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196627001616	S-adenosylmethionine binding site [chemical binding]; other site
196627001617	TIGR02611 family protein; Region: TIGR02611
196627001618	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
196627001619	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
196627001620	active site
196627001621	catalytic residues [active]
196627001622	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
196627001623	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
196627001624	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
196627001625	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
196627001626	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
196627001627	type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931
196627001628	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
196627001629	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
196627001630	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
196627001631	23S rRNA interface [nucleotide binding]; other site
196627001632	L3 interface [polypeptide binding]; other site
196627001633	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
196627001634	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
196627001635	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
196627001636	active site
196627001637	substrate binding site [chemical binding]; other site
196627001638	metal binding site [ion binding]; metal-binding site
196627001639	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
196627001640	alanine racemase; Reviewed; Region: alr; PRK00053
196627001641	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
196627001642	active site
196627001643	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
196627001644	dimer interface [polypeptide binding]; other site
196627001645	substrate binding site [chemical binding]; other site
196627001646	catalytic residues [active]
196627001647	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
196627001648	Predicted permease [General function prediction only]; Region: COG2985
196627001649	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
196627001650	TrkA-C domain; Region: TrkA_C; pfam02080
196627001651	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
196627001652	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
196627001653	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
196627001654	Glycoprotease family; Region: Peptidase_M22; pfam00814
196627001655	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
196627001656	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
196627001657	Coenzyme A binding pocket [chemical binding]; other site
196627001658	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
196627001659	UGMP family protein; Validated; Region: PRK09604
196627001660	Uncharacterized conserved protein [Function unknown]; Region: COG0062
196627001661	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
196627001662	putative substrate binding site [chemical binding]; other site
196627001663	putative ATP binding site [chemical binding]; other site
196627001664	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
196627001665	oligomerisation interface [polypeptide binding]; other site
196627001666	mobile loop; other site
196627001667	roof hairpin; other site
196627001668	chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777
196627001669	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
196627001670	Transposase; Region: DDE_Tnp_ISL3; pfam01610
196627001671	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
196627001672	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
196627001673	hinge regions; other site
196627001674	ATP/Mg binding site [chemical binding]; other site
196627001675	stacking interactions; other site
196627001676	Transcription factor WhiB; Region: Whib; pfam02467
196627001677	RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648
196627001678	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
196627001679	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196627001680	DNA binding residues [nucleotide binding]
196627001681	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
196627001682	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
196627001683	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
196627001684	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
196627001685	active site
196627001686	IMP dehydrogenase family protein; Region: IMP_DH_rel_2; TIGR01304
196627001687	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
196627001688	phosphate binding site [ion binding]; other site
196627001689	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
196627001690	EamA-like transporter family; Region: EamA; pfam00892
196627001691	Transcriptional regulator [Transcription]; Region: LysR; COG0583
196627001692	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
196627001693	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
196627001694	putative dimerization interface [polypeptide binding]; other site
196627001695	GMP synthase; Reviewed; Region: guaA; PRK00074
196627001696	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
196627001697	AMP/PPi binding site [chemical binding]; other site
196627001698	candidate oxyanion hole; other site
196627001699	catalytic triad [active]
196627001700	potential glutamine specificity residues [chemical binding]; other site
196627001701	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
196627001702	ATP Binding subdomain [chemical binding]; other site
196627001703	Ligand Binding sites [chemical binding]; other site
196627001704	Dimerization subdomain; other site
196627001705	PspC domain; Region: PspC; cl00864
196627001706	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
196627001707	PspC domain; Region: PspC; pfam04024
196627001708	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
196627001709	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196627001710	ATP binding site [chemical binding]; other site
196627001711	Mg2+ binding site [ion binding]; other site
196627001712	G-X-G motif; other site
196627001713	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
196627001714	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196627001715	active site
196627001716	phosphorylation site [posttranslational modification]
196627001717	intermolecular recognition site; other site
196627001718	dimerization interface [polypeptide binding]; other site
196627001719	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
196627001720	dimerization interface [polypeptide binding]; other site
196627001721	DNA binding residues [nucleotide binding]
196627001722	DNA Polymerase Y-family; Region: PolY_like; cd03468
196627001723	active site
196627001724	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
196627001725	DNA binding site [nucleotide binding]
196627001726	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
196627001727	putative dimer interface [polypeptide binding]; other site
196627001728	putative [2Fe-2S] cluster binding site [ion binding]; other site
196627001729	prenyltransferase; Reviewed; Region: ubiA; PRK13105
196627001730	UbiA prenyltransferase family; Region: UbiA; pfam01040
196627001731	lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462
196627001732	lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462
196627001733	phytoene desaturase; Region: crtI_fam; TIGR02734
196627001734	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
196627001735	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
196627001736	active site lid residues [active]
196627001737	substrate binding pocket [chemical binding]; other site
196627001738	catalytic residues [active]
196627001739	substrate-Mg2+ binding site; other site
196627001740	aspartate-rich region 1; other site
196627001741	aspartate-rich region 2; other site
196627001742	MMPL family; Region: MMPL; pfam03176
196627001743	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
196627001744	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
196627001745	substrate binding pocket [chemical binding]; other site
196627001746	chain length determination region; other site
196627001747	substrate-Mg2+ binding site; other site
196627001748	catalytic residues [active]
196627001749	aspartate-rich region 1; other site
196627001750	active site lid residues [active]
196627001751	aspartate-rich region 2; other site
196627001752	Transcriptional regulators [Transcription]; Region: MarR; COG1846
196627001753	MarR family; Region: MarR_2; pfam12802
196627001754	Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040
196627001755	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
196627001756	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
196627001757	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196627001758	NAD(P) binding site [chemical binding]; other site
196627001759	active site
196627001760	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
196627001761	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
196627001762	DNA photolyase; Region: DNA_photolyase; pfam00875
196627001763	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
196627001764	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
196627001765	active site
196627001766	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
196627001767	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
196627001768	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
196627001769	FtsX-like permease family; Region: FtsX; pfam02687
196627001770	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
196627001771	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
196627001772	Walker A/P-loop; other site
196627001773	ATP binding site [chemical binding]; other site
196627001774	Q-loop/lid; other site
196627001775	ABC transporter signature motif; other site
196627001776	Walker B; other site
196627001777	D-loop; other site
196627001778	H-loop/switch region; other site
196627001779	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196627001780	dimer interface [polypeptide binding]; other site
196627001781	conserved gate region; other site
196627001782	putative PBP binding loops; other site
196627001783	ABC-ATPase subunit interface; other site
196627001784	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
196627001785	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
196627001786	Walker A/P-loop; other site
196627001787	ATP binding site [chemical binding]; other site
196627001788	Q-loop/lid; other site
196627001789	ABC transporter signature motif; other site
196627001790	Walker B; other site
196627001791	D-loop; other site
196627001792	H-loop/switch region; other site
196627001793	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
196627001794	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
196627001795	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
196627001796	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
196627001797	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
196627001798	active site
196627001799	PHP Thumb interface [polypeptide binding]; other site
196627001800	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
196627001801	generic binding surface II; other site
196627001802	generic binding surface I; other site
196627001803	Uncharacterized conserved protein [Function unknown]; Region: COG3402
196627001804	Predicted membrane protein [Function unknown]; Region: COG3428
196627001805	Bacterial PH domain; Region: DUF304; pfam03703
196627001806	Bacterial PH domain; Region: DUF304; cl01348
196627001807	Bacterial PH domain; Region: DUF304; pfam03703
196627001808	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
196627001809	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
196627001810	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
196627001811	FeoA domain; Region: FeoA; pfam04023
196627001812	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
196627001813	NAD-dependent deacetylase; Provisional; Region: PRK00481
196627001814	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
196627001815	NAD+ binding site [chemical binding]; other site
196627001816	substrate binding site [chemical binding]; other site
196627001817	Zn binding site [ion binding]; other site
196627001818	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
196627001819	nucleoside/Zn binding site; other site
196627001820	dimer interface [polypeptide binding]; other site
196627001821	catalytic motif [active]
196627001822	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
196627001823	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
196627001824	siderophore binding site; other site
196627001825	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
196627001826	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
196627001827	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
196627001828	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
196627001829	homodimer interface [polypeptide binding]; other site
196627001830	NADP binding site [chemical binding]; other site
196627001831	substrate binding site [chemical binding]; other site
196627001832	Protein of unknown function (DUF3017); Region: DUF3017; pfam11222
196627001833	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
196627001834	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
196627001835	Protein of unknown function (DUF3500); Region: DUF3500; pfam12006
196627001836	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
196627001837	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
196627001838	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05613
196627001839	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
196627001840	homodimer interface [polypeptide binding]; other site
196627001841	substrate-cofactor binding pocket; other site
196627001842	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196627001843	catalytic residue [active]
196627001844	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
196627001845	Carbon starvation protein CstA; Region: CstA; pfam02554
196627001846	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
196627001847	Protein of unknown function (DUF466); Region: DUF466; pfam04328
196627001848	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
196627001849	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
196627001850	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
196627001851	tetramer interface [polypeptide binding]; other site
196627001852	active site
196627001853	Mg2+/Mn2+ binding site [ion binding]; other site
196627001854	citrate synthase; Provisional; Region: PRK14033
196627001855	Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111
196627001856	dimer interface [polypeptide binding]; other site
196627001857	active site
196627001858	citrylCoA binding site [chemical binding]; other site
196627001859	oxalacetate/citrate binding site [chemical binding]; other site
196627001860	coenzyme A binding site [chemical binding]; other site
196627001861	catalytic triad [active]
196627001862	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
196627001863	Transcriptional regulators [Transcription]; Region: GntR; COG1802
196627001864	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
196627001865	DNA-binding site [nucleotide binding]; DNA binding site
196627001866	FCD domain; Region: FCD; pfam07729
196627001867	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
196627001868	isocitrate dehydrogenase, NADP-dependent, monomeric type; Region: monomer_idh; TIGR00178
196627001869	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
196627001870	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
196627001871	FAD binding pocket [chemical binding]; other site
196627001872	FAD binding motif [chemical binding]; other site
196627001873	phosphate binding motif [ion binding]; other site
196627001874	NAD binding pocket [chemical binding]; other site
196627001875	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
196627001876	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
196627001877	Walker A/P-loop; other site
196627001878	ATP binding site [chemical binding]; other site
196627001879	Q-loop/lid; other site
196627001880	ABC transporter signature motif; other site
196627001881	Walker B; other site
196627001882	D-loop; other site
196627001883	H-loop/switch region; other site
196627001884	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
196627001885	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
196627001886	ABC-ATPase subunit  interface; other site
196627001887	dimer interface [polypeptide binding]; other site
196627001888	putative PBP binding regions; other site
196627001889	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
196627001890	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
196627001891	ABC-ATPase subunit  interface; other site
196627001892	dimer interface [polypeptide binding]; other site
196627001893	putative PBP binding regions; other site
196627001894	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
196627001895	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
196627001896	siderophore binding site; other site
196627001897	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627001898	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
196627001899	putative substrate translocation pore; other site
196627001900	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
196627001901	putative catalytic site [active]
196627001902	putative metal binding site [ion binding]; other site
196627001903	putative phosphate binding site [ion binding]; other site
196627001904	Predicted membrane protein [Function unknown]; Region: COG2860
196627001905	UPF0126 domain; Region: UPF0126; pfam03458
196627001906	UPF0126 domain; Region: UPF0126; pfam03458
196627001907	Periplasmic binding protein TroA_d.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141
196627001908	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
196627001909	putative ligand binding site [chemical binding]; other site
196627001910	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
196627001911	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
196627001912	Walker A/P-loop; other site
196627001913	ATP binding site [chemical binding]; other site
196627001914	Q-loop/lid; other site
196627001915	ABC transporter signature motif; other site
196627001916	Walker B; other site
196627001917	D-loop; other site
196627001918	H-loop/switch region; other site
196627001919	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
196627001920	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
196627001921	ABC-ATPase subunit  interface; other site
196627001922	dimer interface [polypeptide binding]; other site
196627001923	putative PBP binding regions; other site
196627001924	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
196627001925	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
196627001926	active site
196627001927	HIGH motif; other site
196627001928	dimer interface [polypeptide binding]; other site
196627001929	KMSKS motif; other site
196627001930	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
196627001931	RDD family; Region: RDD; pfam06271
196627001932	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
196627001933	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
196627001934	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
196627001935	NlpC/P60 family; Region: NLPC_P60; pfam00877
196627001936	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
196627001937	active site
196627001938	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
196627001939	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
196627001940	non-specific DNA binding site [nucleotide binding]; other site
196627001941	salt bridge; other site
196627001942	sequence-specific DNA binding site [nucleotide binding]; other site
196627001943	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
196627001944	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
196627001945	active site
196627001946	substrate binding site [chemical binding]; other site
196627001947	metal binding site [ion binding]; metal-binding site
196627001948	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
196627001949	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
196627001950	metal binding site [ion binding]; metal-binding site
196627001951	putative dimer interface [polypeptide binding]; other site
196627001952	flavoprotein disulfide reductase; Reviewed; Region: PRK07845
196627001953	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
196627001954	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
196627001955	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
196627001956	pyruvate carboxylase; Reviewed; Region: PRK12999
196627001957	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
196627001958	ATP-grasp domain; Region: ATP-grasp_4; cl17255
196627001959	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
196627001960	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
196627001961	active site
196627001962	catalytic residues [active]
196627001963	metal binding site [ion binding]; metal-binding site
196627001964	homodimer binding site [polypeptide binding]; other site
196627001965	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
196627001966	carboxyltransferase (CT) interaction site; other site
196627001967	biotinylation site [posttranslational modification]; other site
196627001968	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
196627001969	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
196627001970	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
196627001971	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
196627001972	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
196627001973	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
196627001974	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
196627001975	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
196627001976	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
196627001977	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
196627001978	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
196627001979	tetramer interface [polypeptide binding]; other site
196627001980	active site
196627001981	Mg2+/Mn2+ binding site [ion binding]; other site
196627001982	citrate synthase; Provisional; Region: PRK14033
196627001983	Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111
196627001984	dimer interface [polypeptide binding]; other site
196627001985	active site
196627001986	citrylCoA binding site [chemical binding]; other site
196627001987	oxalacetate/citrate binding site [chemical binding]; other site
196627001988	coenzyme A binding site [chemical binding]; other site
196627001989	catalytic triad [active]
196627001990	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
196627001991	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
196627001992	non-specific DNA binding site [nucleotide binding]; other site
196627001993	salt bridge; other site
196627001994	sequence-specific DNA binding site [nucleotide binding]; other site
196627001995	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
196627001996	Domain of unknown function (DUF955); Region: DUF955; pfam06114
196627001997	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
196627001998	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
196627001999	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
196627002000	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
196627002001	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
196627002002	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
196627002003	carboxyltransferase (CT) interaction site; other site
196627002004	biotinylation site [posttranslational modification]; other site
196627002005	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
196627002006	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
196627002007	active site residue [active]
196627002008	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
196627002009	active site residue [active]
196627002010	Protein of unknown function (DUF3151); Region: DUF3151; pfam11349
196627002011	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
196627002012	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
196627002013	Maf-like protein; Region: Maf; pfam02545
196627002014	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
196627002015	active site
196627002016	dimer interface [polypeptide binding]; other site
196627002017	Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822
196627002018	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
196627002019	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
196627002020	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
196627002021	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
196627002022	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
196627002023	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
196627002024	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
196627002025	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
196627002026	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
196627002027	ATP-grasp domain; Region: ATP-grasp; pfam02222
196627002028	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
196627002029	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
196627002030	Uncharacterized conserved protein [Function unknown]; Region: COG1434
196627002031	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
196627002032	putative active site [active]
196627002033	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
196627002034	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
196627002035	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
196627002036	active site
196627002037	non-prolyl cis peptide bond; other site
196627002038	Winged helix-turn helix; Region: HTH_29; pfam13551
196627002039	Helix-turn-helix domain; Region: HTH_28; pfam13518
196627002040	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
196627002041	Integrase core domain; Region: rve; pfam00665
196627002042	Integrase core domain; Region: rve_3; pfam13683
196627002043	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642
196627002044	putative beta-ketoacyl acyl carrier protein [ACP]reductase (BKR), subgroup 2, classical (c) SDR; Region: BKR_2_SDR_c; cd05349
196627002045	putative NAD(P) binding site [chemical binding]; other site
196627002046	active site
196627002047	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
196627002048	RibD C-terminal domain; Region: RibD_C; cl17279
196627002049	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353
196627002050	putative dimer interface [polypeptide binding]; other site
196627002051	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
196627002052	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
196627002053	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196627002054	dimer interface [polypeptide binding]; other site
196627002055	conserved gate region; other site
196627002056	putative PBP binding loops; other site
196627002057	ABC-ATPase subunit interface; other site
196627002058	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196627002059	dimer interface [polypeptide binding]; other site
196627002060	conserved gate region; other site
196627002061	putative PBP binding loops; other site
196627002062	ABC-ATPase subunit interface; other site
196627002063	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901
196627002064	putative hydrophobic ligand binding site [chemical binding]; other site
196627002065	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
196627002066	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
196627002067	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
196627002068	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
196627002069	Walker A/P-loop; other site
196627002070	ATP binding site [chemical binding]; other site
196627002071	Q-loop/lid; other site
196627002072	ABC transporter signature motif; other site
196627002073	Walker B; other site
196627002074	D-loop; other site
196627002075	H-loop/switch region; other site
196627002076	TOBE domain; Region: TOBE_2; pfam08402
196627002077	Predicted membrane protein (DUF2127); Region: DUF2127; cl01785
196627002078	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
196627002079	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196627002080	ATP binding site [chemical binding]; other site
196627002081	putative Mg++ binding site [ion binding]; other site
196627002082	helicase superfamily c-terminal domain; Region: HELICc; smart00490
196627002083	ATP-binding site [chemical binding]; other site
196627002084	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
196627002085	TIGR03089 family protein; Region: TIGR03089
196627002086	Protein of unknown function DUF262; Region: DUF262; pfam03235
196627002087	Uncharacterized conserved protein [Function unknown]; Region: COG1479
196627002088	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
196627002089	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
196627002090	Family description; Region: UvrD_C_2; pfam13538
196627002091	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
196627002092	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196627002093	ATP binding site [chemical binding]; other site
196627002094	putative Mg++ binding site [ion binding]; other site
196627002095	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
196627002096	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196627002097	ATP-binding site [chemical binding]; other site
196627002098	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
196627002099	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
196627002100	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
196627002101	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196627002102	ATP binding site [chemical binding]; other site
196627002103	putative Mg++ binding site [ion binding]; other site
196627002104	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196627002105	nucleotide binding region [chemical binding]; other site
196627002106	ATP-binding site [chemical binding]; other site
196627002107	Transcriptional regulator [Transcription]; Region: LytR; COG1316
196627002108	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
196627002109	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
196627002110	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
196627002111	Probable Catalytic site; other site
196627002112	metal-binding site
196627002113	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
196627002114	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
196627002115	active site
196627002116	Substrate binding site; other site
196627002117	Mg++ binding site; other site
196627002118	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
196627002119	putative trimer interface [polypeptide binding]; other site
196627002120	putative CoA binding site [chemical binding]; other site
196627002121	Transcription factor WhiB; Region: Whib; pfam02467
196627002122	Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
196627002123	Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
196627002124	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
196627002125	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
196627002126	active site
196627002127	substrate binding site [chemical binding]; other site
196627002128	metal binding site [ion binding]; metal-binding site
196627002129	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
196627002130	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
196627002131	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
196627002132	Domain of unknown function (DUF4259); Region: DUF4259; pfam14078
196627002133	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
196627002134	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
196627002135	homotetramer interface [polypeptide binding]; other site
196627002136	ligand binding site [chemical binding]; other site
196627002137	catalytic site [active]
196627002138	NAD binding site [chemical binding]; other site
196627002139	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
196627002140	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
196627002141	TMP-binding site; other site
196627002142	ATP-binding site [chemical binding]; other site
196627002143	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
196627002144	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196627002145	active site
196627002146	phosphorylation site [posttranslational modification]
196627002147	intermolecular recognition site; other site
196627002148	dimerization interface [polypeptide binding]; other site
196627002149	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
196627002150	DNA binding site [nucleotide binding]
196627002151	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
196627002152	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
196627002153	dimerization interface [polypeptide binding]; other site
196627002154	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196627002155	dimer interface [polypeptide binding]; other site
196627002156	phosphorylation site [posttranslational modification]
196627002157	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196627002158	ATP binding site [chemical binding]; other site
196627002159	Mg2+ binding site [ion binding]; other site
196627002160	G-X-G motif; other site
196627002161	lipoprotein LpqB; Provisional; Region: PRK13616
196627002162	Sporulation and spore germination; Region: Germane; pfam10646
196627002163	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
196627002164	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
196627002165	active site
196627002166	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
196627002167	30S subunit binding site; other site
196627002168	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
196627002169	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
196627002170	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
196627002171	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
196627002172	nucleotide binding region [chemical binding]; other site
196627002173	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
196627002174	REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252
196627002175	Predicted GTPases [General function prediction only]; Region: COG1162
196627002176	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
196627002177	GTPase/Zn-binding domain interface [polypeptide binding]; other site
196627002178	GTP/Mg2+ binding site [chemical binding]; other site
196627002179	G4 box; other site
196627002180	G1 box; other site
196627002181	Switch I region; other site
196627002182	G2 box; other site
196627002183	G3 box; other site
196627002184	Switch II region; other site
196627002185	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
196627002186	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
196627002187	hinge; other site
196627002188	active site
196627002189	Uncharacterized conserved protein [Function unknown]; Region: COG2135
196627002190	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
196627002191	active site
196627002192	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
196627002193	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
196627002194	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196627002195	DNA binding residues [nucleotide binding]
196627002196	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988
196627002197	Transcription factor WhiB; Region: Whib; pfam02467
196627002198	PQQ-like domain; Region: PQQ_2; pfam13360
196627002199	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
196627002200	DEAD-like helicases superfamily; Region: DEXDc; smart00487
196627002201	ATP binding site [chemical binding]; other site
196627002202	Mg++ binding site [ion binding]; other site
196627002203	motif III; other site
196627002204	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196627002205	nucleotide binding region [chemical binding]; other site
196627002206	ATP-binding site [chemical binding]; other site
196627002207	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
196627002208	Protein of unknown function (DUF3152); Region: DUF3152; pfam11350
196627002209	TIGR02569 family protein; Region: TIGR02569_actnb
196627002210	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
196627002211	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
196627002212	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
196627002213	Family description; Region: UvrD_C_2; pfam13538
196627002214	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
196627002215	Ion channel; Region: Ion_trans_2; pfam07885
196627002216	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
196627002217	TrkA-N domain; Region: TrkA_N; pfam02254
196627002218	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
196627002219	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
196627002220	putative NADH binding site [chemical binding]; other site
196627002221	putative active site [active]
196627002222	nudix motif; other site
196627002223	putative metal binding site [ion binding]; other site
196627002224	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
196627002225	Part of AAA domain; Region: AAA_19; pfam13245
196627002226	Family description; Region: UvrD_C_2; pfam13538
196627002227	HRDC domain; Region: HRDC; pfam00570
196627002228	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
196627002229	Uncharacterized conserved protein [Function unknown]; Region: COG5282
196627002230	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
196627002231	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
196627002232	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
196627002233	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
196627002234	hypothetical protein; Validated; Region: PRK00068
196627002235	Uncharacterized conserved protein [Function unknown]; Region: COG1615
196627002236	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
196627002237	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
196627002238	DNA-binding site [nucleotide binding]; DNA binding site
196627002239	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
196627002240	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196627002241	homodimer interface [polypeptide binding]; other site
196627002242	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
196627002243	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
196627002244	active site
196627002245	multimer interface [polypeptide binding]; other site
196627002246	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
196627002247	predicted active site [active]
196627002248	catalytic triad [active]
196627002249	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
196627002250	substrate binding sites [chemical binding]; other site
196627002251	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
196627002252	LGFP repeat; Region: LGFP; pfam08310
196627002253	LGFP repeat; Region: LGFP; pfam08310
196627002254	LGFP repeat; Region: LGFP; pfam08310
196627002255	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
196627002256	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
196627002257	active site
196627002258	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
196627002259	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
196627002260	active site
196627002261	peptide chain release factor 2; Validated; Region: prfB; PRK00578
196627002262	This domain is found in peptide chain release factors; Region: PCRF; smart00937
196627002263	RF-1 domain; Region: RF-1; pfam00472
196627002264	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
196627002265	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196627002266	Walker A/P-loop; other site
196627002267	ATP binding site [chemical binding]; other site
196627002268	Q-loop/lid; other site
196627002269	ABC transporter signature motif; other site
196627002270	Walker B; other site
196627002271	D-loop; other site
196627002272	H-loop/switch region; other site
196627002273	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
196627002274	FtsX-like permease family; Region: FtsX; pfam02687
196627002275	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
196627002276	SmpB-tmRNA interface; other site
196627002277	Uncharacterized conserved protein [Function unknown]; Region: COG3189
196627002278	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
196627002279	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
196627002280	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
196627002281	FAD binding pocket [chemical binding]; other site
196627002282	FAD binding motif [chemical binding]; other site
196627002283	phosphate binding motif [ion binding]; other site
196627002284	NAD binding pocket [chemical binding]; other site
196627002285	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
196627002286	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
196627002287	siderophore binding site; other site
196627002288	Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922
196627002289	putative active site [active]
196627002290	redox center [active]
196627002291	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
196627002292	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
196627002293	intersubunit interface [polypeptide binding]; other site
196627002294	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
196627002295	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
196627002296	ABC-ATPase subunit  interface; other site
196627002297	dimer interface [polypeptide binding]; other site
196627002298	putative PBP binding regions; other site
196627002299	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
196627002300	ABC-ATPase subunit  interface; other site
196627002301	dimer interface [polypeptide binding]; other site
196627002302	putative PBP binding regions; other site
196627002303	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
196627002304	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
196627002305	Walker A/P-loop; other site
196627002306	ATP binding site [chemical binding]; other site
196627002307	Q-loop/lid; other site
196627002308	ABC transporter signature motif; other site
196627002309	Walker B; other site
196627002310	D-loop; other site
196627002311	H-loop/switch region; other site
196627002312	16S_rRNA_copy_B
196627002313	aminotransferase; Validated; Region: PRK07777
196627002314	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
196627002315	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196627002316	homodimer interface [polypeptide binding]; other site
196627002317	catalytic residue [active]
196627002318	Protein of unknown function (DUF3239); Region: DUF3239; pfam11580
196627002319	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
196627002320	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
196627002321	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196627002322	ATP binding site [chemical binding]; other site
196627002323	putative Mg++ binding site [ion binding]; other site
196627002324	helicase superfamily c-terminal domain; Region: HELICc; smart00490
196627002325	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
196627002326	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
196627002327	Protein of unknown function (DUF3235); Region: DUF3235; pfam11574
196627002328	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
196627002329	DNA-binding site [nucleotide binding]; DNA binding site
196627002330	RNA-binding motif; other site
196627002331	Protein of unknown function (DUF2771); Region: DUF2771; pfam10969
196627002332	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
196627002333	substrate-cofactor binding pocket; other site
196627002334	homodimer interface [polypeptide binding]; other site
196627002335	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
196627002336	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
196627002337	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196627002338	catalytic residue [active]
196627002339	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
196627002340	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
196627002341	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
196627002342	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
196627002343	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
196627002344	phosphoserine aminotransferase, putative; Region: serC_3; TIGR01366
196627002345	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
196627002346	catalytic residue [active]
196627002347	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
196627002348	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
196627002349	dimer interface [polypeptide binding]; other site
196627002350	active site
196627002351	citrylCoA binding site [chemical binding]; other site
196627002352	NADH binding [chemical binding]; other site
196627002353	cationic pore residues; other site
196627002354	oxalacetate/citrate binding site [chemical binding]; other site
196627002355	coenzyme A binding site [chemical binding]; other site
196627002356	catalytic triad [active]
196627002357	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
196627002358	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
196627002359	Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777
196627002360	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
196627002361	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825
196627002362	Predicted membrane protein [Function unknown]; Region: COG3162
196627002363	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
196627002364	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
196627002365	Na binding site [ion binding]; other site
196627002366	Domain of unknown function (DUF1906); Region: DUF1906; pfam08924
196627002367	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
196627002368	Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981
196627002369	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
196627002370	phosphate binding site [ion binding]; other site
196627002371	Domain of unknown function (DUF1729); Region: DUF1729; pfam08354
196627002372	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
196627002373	active site 2 [active]
196627002374	active site 1 [active]
196627002375	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
196627002376	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
196627002377	3-oxoacyl-[acyl-carrier protein]; Region: COG4982
196627002378	ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950
196627002379	putative NAD(P) binding site [chemical binding]; other site
196627002380	active site
196627002381	"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828
196627002382	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
196627002383	active site
196627002384	Septum formation; Region: Septum_form; pfam13845
196627002385	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
196627002386	hypothetical protein; Validated; Region: PRK07581
196627002387	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
196627002388	catalytic residues [active]
196627002389	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
196627002390	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
196627002391	folate binding site [chemical binding]; other site
196627002392	NADP+ binding site [chemical binding]; other site
196627002393	thymidylate synthase; Reviewed; Region: thyA; PRK01827
196627002394	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
196627002395	dimerization interface [polypeptide binding]; other site
196627002396	active site
196627002397	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
196627002398	active site
196627002399	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196627002400	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
196627002401	ATP binding site [chemical binding]; other site
196627002402	putative Mg++ binding site [ion binding]; other site
196627002403	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196627002404	nucleotide binding region [chemical binding]; other site
196627002405	ATP-binding site [chemical binding]; other site
196627002406	DEAD/H associated; Region: DEAD_assoc; pfam08494
196627002407	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
196627002408	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
196627002409	putative DNA binding site [nucleotide binding]; other site
196627002410	catalytic residue [active]
196627002411	putative H2TH interface [polypeptide binding]; other site
196627002412	putative catalytic residues [active]
196627002413	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
196627002414	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
196627002415	Predicted membrane protein [Function unknown]; Region: COG3304
196627002416	Domain of unknown function (DUF307); Region: DUF307; pfam03733
196627002417	Domain of unknown function (DUF307); Region: DUF307; pfam03733
196627002418	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
196627002419	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
196627002420	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
196627002421	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627002422	putative substrate translocation pore; other site
196627002423	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
196627002424	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
196627002425	active site
196627002426	dimer interface [polypeptide binding]; other site
196627002427	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
196627002428	dimer interface [polypeptide binding]; other site
196627002429	active site
196627002430	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
196627002431	active site
196627002432	hypothetical protein; Provisional; Region: PRK07857
196627002433	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
196627002434	Part of AAA domain; Region: AAA_19; pfam13245
196627002435	Family description; Region: UvrD_C_2; pfam13538
196627002436	FtsX-like permease family; Region: FtsX; pfam02687
196627002437	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
196627002438	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
196627002439	Walker A/P-loop; other site
196627002440	ATP binding site [chemical binding]; other site
196627002441	Q-loop/lid; other site
196627002442	ABC transporter signature motif; other site
196627002443	Walker B; other site
196627002444	D-loop; other site
196627002445	H-loop/switch region; other site
196627002446	Predicted transcriptional regulators [Transcription]; Region: COG1695
196627002447	Transcriptional regulator PadR-like family; Region: PadR; cl17335
196627002448	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
196627002449	Peptidase family M23; Region: Peptidase_M23; pfam01551
196627002450	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
196627002451	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
196627002452	active site
196627002453	substrate binding site [chemical binding]; other site
196627002454	cosubstrate binding site; other site
196627002455	catalytic site [active]
196627002456	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
196627002457	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
196627002458	purine monophosphate binding site [chemical binding]; other site
196627002459	dimer interface [polypeptide binding]; other site
196627002460	putative catalytic residues [active]
196627002461	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
196627002462	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
196627002463	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
196627002464	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196627002465	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196627002466	30S ribosomal protein S18; Provisional; Region: PRK13401
196627002467	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
196627002468	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
196627002469	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
196627002470	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
196627002471	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
196627002472	Sulfate transporter family; Region: Sulfate_transp; pfam00916
196627002473	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
196627002474	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196627002475	dimerization interface [polypeptide binding]; other site
196627002476	putative DNA binding site [nucleotide binding]; other site
196627002477	putative Zn2+ binding site [ion binding]; other site
196627002478	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
196627002479	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
196627002480	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
196627002481	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196627002482	active site
196627002483	phosphorylation site [posttranslational modification]
196627002484	intermolecular recognition site; other site
196627002485	dimerization interface [polypeptide binding]; other site
196627002486	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
196627002487	DNA binding site [nucleotide binding]
196627002488	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
196627002489	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
196627002490	dimerization interface [polypeptide binding]; other site
196627002491	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196627002492	dimer interface [polypeptide binding]; other site
196627002493	phosphorylation site [posttranslational modification]
196627002494	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196627002495	ATP binding site [chemical binding]; other site
196627002496	Mg2+ binding site [ion binding]; other site
196627002497	G-X-G motif; other site
196627002498	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
196627002499	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
196627002500	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
196627002501	protein binding site [polypeptide binding]; other site
196627002502	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
196627002503	MPT binding site; other site
196627002504	trimer interface [polypeptide binding]; other site
196627002505	ADDz for ATRX, Dnmt3 and Dnmt3l PHD-like zinc finger domain; Region: ADDz; cl17040
196627002506	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
196627002507	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
196627002508	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
196627002509	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
196627002510	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
196627002511	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
196627002512	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
196627002513	active site
196627002514	tetramer interface; other site
196627002515	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
196627002516	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
196627002517	dimer interface [polypeptide binding]; other site
196627002518	putative functional site; other site
196627002519	putative MPT binding site; other site
196627002520	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
196627002521	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
196627002522	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
196627002523	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627002524	putative substrate translocation pore; other site
196627002525	Predicted membrane protein [Function unknown]; Region: COG2259
196627002526	Predicted integral membrane protein [Function unknown]; Region: COG5660
196627002527	Putative zinc-finger; Region: zf-HC2; pfam13490
196627002528	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354
196627002529	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
196627002530	active site
196627002531	catalytic site [active]
196627002532	Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928
196627002533	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
196627002534	Predicted methyltransferases [General function prediction only]; Region: COG0313
196627002535	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
196627002536	putative SAM binding site [chemical binding]; other site
196627002537	putative homodimer interface [polypeptide binding]; other site
196627002538	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
196627002539	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
196627002540	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
196627002541	active site
196627002542	HIGH motif; other site
196627002543	KMSKS motif; other site
196627002544	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
196627002545	tRNA binding surface [nucleotide binding]; other site
196627002546	anticodon binding site; other site
196627002547	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
196627002548	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196627002549	ATP binding site [chemical binding]; other site
196627002550	putative Mg++ binding site [ion binding]; other site
196627002551	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196627002552	nucleotide binding region [chemical binding]; other site
196627002553	ATP-binding site [chemical binding]; other site
196627002554	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
196627002555	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
196627002556	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
196627002557	putative transposase OrfB; Reviewed; Region: PHA02517
196627002558	Integrase core domain; Region: rve; pfam00665
196627002559	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
196627002560	Transposase; Region: DDE_Tnp_ISL3; pfam01610
196627002561	D-lactate dehydrogenase; Provisional; Region: PRK11183
196627002562	FAD binding domain; Region: FAD_binding_4; pfam01565
196627002563	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
196627002564	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
196627002565	DNA methylase; Region: N6_N4_Mtase; pfam01555
196627002566	putative transposase OrfB; Reviewed; Region: PHA02517
196627002567	Integrase core domain; Region: rve; pfam00665
196627002568	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196627002569	dimerization interface [polypeptide binding]; other site
196627002570	putative DNA binding site [nucleotide binding]; other site
196627002571	putative Zn2+ binding site [ion binding]; other site
196627002572	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
196627002573	Cadmium resistance transporter; Region: Cad; pfam03596
196627002574	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
196627002575	active site
196627002576	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
196627002577	Domain of unknown function (DUF348); Region: DUF348; pfam03990
196627002578	Domain of unknown function (DUF348); Region: DUF348; pfam03990
196627002579	G5 domain; Region: G5; pfam07501
196627002580	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
196627002581	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
196627002582	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196627002583	S-adenosylmethionine binding site [chemical binding]; other site
196627002584	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
196627002585	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
196627002586	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
196627002587	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
196627002588	ABC transporter; Region: ABC_tran_2; pfam12848
196627002589	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
196627002590	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
196627002591	dimer interface [polypeptide binding]; other site
196627002592	pyridoxal binding site [chemical binding]; other site
196627002593	ATP binding site [chemical binding]; other site
196627002594	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
196627002595	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
196627002596	catalytic residues [active]
196627002597	Uncharacterized conserved protein [Function unknown]; Region: COG1359
196627002598	Uncharacterized conserved protein [Function unknown]; Region: COG1359
196627002599	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
196627002600	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
196627002601	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
196627002602	active site
196627002603	motif I; other site
196627002604	motif II; other site
196627002605	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
196627002606	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
196627002607	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
196627002608	substrate binding site [chemical binding]; other site
196627002609	oxyanion hole (OAH) forming residues; other site
196627002610	trimer interface [polypeptide binding]; other site
196627002611	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
196627002612	Predicted membrane protein [General function prediction only]; Region: COG4194
196627002613	Predicted esterase [General function prediction only]; Region: COG0627
196627002614	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196627002615	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
196627002616	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
196627002617	Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048
196627002618	Domain of unknown function (DUF222); Region: DUF222; pfam02720
196627002619	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
196627002620	active site
196627002621	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
196627002622	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
196627002623	G1 box; other site
196627002624	putative GEF interaction site [polypeptide binding]; other site
196627002625	GTP/Mg2+ binding site [chemical binding]; other site
196627002626	Switch I region; other site
196627002627	G2 box; other site
196627002628	G3 box; other site
196627002629	Switch II region; other site
196627002630	G4 box; other site
196627002631	G5 box; other site
196627002632	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
196627002633	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
196627002634	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
196627002635	putative ligand binding site [chemical binding]; other site
196627002636	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
196627002637	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
196627002638	TM-ABC transporter signature motif; other site
196627002639	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
196627002640	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
196627002641	TM-ABC transporter signature motif; other site
196627002642	Uncharacterized ABC-type transport system, ATPase component [General function prediction only]; Region: COG4674
196627002643	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
196627002644	Walker A/P-loop; other site
196627002645	ATP binding site [chemical binding]; other site
196627002646	Q-loop/lid; other site
196627002647	ABC transporter signature motif; other site
196627002648	Walker B; other site
196627002649	D-loop; other site
196627002650	H-loop/switch region; other site
196627002651	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
196627002652	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
196627002653	Walker A/P-loop; other site
196627002654	ATP binding site [chemical binding]; other site
196627002655	Q-loop/lid; other site
196627002656	ABC transporter signature motif; other site
196627002657	Walker B; other site
196627002658	D-loop; other site
196627002659	H-loop/switch region; other site
196627002660	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
196627002661	putative active site [active]
196627002662	catalytic residue [active]
196627002663	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
196627002664	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
196627002665	FMN binding site [chemical binding]; other site
196627002666	substrate binding site [chemical binding]; other site
196627002667	putative catalytic residue [active]
196627002668	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
196627002669	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
196627002670	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
196627002671	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
196627002672	putative active site [active]
196627002673	catalytic residue [active]
196627002674	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
196627002675	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
196627002676	5S rRNA interface [nucleotide binding]; other site
196627002677	CTC domain interface [polypeptide binding]; other site
196627002678	L16 interface [polypeptide binding]; other site
196627002679	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
196627002680	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
196627002681	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
196627002682	A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
196627002683	active site
196627002684	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
196627002685	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
196627002686	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
196627002687	active site
196627002688	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
196627002689	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
196627002690	Substrate binding site; other site
196627002691	Mg++ binding site; other site
196627002692	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
196627002693	active site
196627002694	substrate binding site [chemical binding]; other site
196627002695	CoA binding site [chemical binding]; other site
196627002696	Major Facilitator Superfamily; Region: MFS_1; pfam07690
196627002697	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
196627002698	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
196627002699	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
196627002700	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
196627002701	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
196627002702	Walker A/P-loop; other site
196627002703	ATP binding site [chemical binding]; other site
196627002704	Q-loop/lid; other site
196627002705	ABC transporter signature motif; other site
196627002706	Walker B; other site
196627002707	D-loop; other site
196627002708	H-loop/switch region; other site
196627002709	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
196627002710	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
196627002711	Histidine kinase; Region: HisKA_3; pfam07730
196627002712	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
196627002713	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196627002714	active site
196627002715	phosphorylation site [posttranslational modification]
196627002716	intermolecular recognition site; other site
196627002717	dimerization interface [polypeptide binding]; other site
196627002718	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
196627002719	DNA binding residues [nucleotide binding]
196627002720	dimerization interface [polypeptide binding]; other site
196627002721	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
196627002722	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
196627002723	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
196627002724	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196627002725	ABC transporter signature motif; other site
196627002726	Walker B; other site
196627002727	D-loop; other site
196627002728	H-loop/switch region; other site
196627002729	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
196627002730	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
196627002731	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196627002732	Walker A/P-loop; other site
196627002733	ATP binding site [chemical binding]; other site
196627002734	Q-loop/lid; other site
196627002735	ABC transporter signature motif; other site
196627002736	Walker B; other site
196627002737	D-loop; other site
196627002738	H-loop/switch region; other site
196627002739	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
196627002740	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
196627002741	Excalibur calcium-binding domain; Region: Excalibur; pfam05901
196627002742	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
196627002743	Integrase core domain; Region: rve; pfam00665
196627002744	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196627002745	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196627002746	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
196627002747	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
196627002748	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196627002749	ATP binding site [chemical binding]; other site
196627002750	putative Mg++ binding site [ion binding]; other site
196627002751	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196627002752	nucleotide binding region [chemical binding]; other site
196627002753	ATP-binding site [chemical binding]; other site
196627002754	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
196627002755	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
196627002756	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
196627002757	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
196627002758	Walker A/P-loop; other site
196627002759	ATP binding site [chemical binding]; other site
196627002760	Q-loop/lid; other site
196627002761	ABC transporter signature motif; other site
196627002762	Walker B; other site
196627002763	D-loop; other site
196627002764	H-loop/switch region; other site
196627002765	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
196627002766	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
196627002767	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196627002768	Walker A/P-loop; other site
196627002769	ATP binding site [chemical binding]; other site
196627002770	Q-loop/lid; other site
196627002771	ABC transporter signature motif; other site
196627002772	Walker B; other site
196627002773	D-loop; other site
196627002774	H-loop/switch region; other site
196627002775	Uncharacterized conserved protein [Function unknown]; Region: COG2898
196627002776	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
196627002777	Predicted esterase [General function prediction only]; Region: COG0627
196627002778	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
196627002779	MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013
196627002780	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
196627002781	homodimer interface [polypeptide binding]; other site
196627002782	metal binding site [ion binding]; metal-binding site
196627002783	Alpha helical Porin B; Region: PorB; pfam11565
196627002784	Alpha helical Porin B; Region: PorB; pfam11565
196627002785	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
196627002786	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
196627002787	N-acetyl-D-glucosamine binding site [chemical binding]; other site
196627002788	enolase; Provisional; Region: eno; PRK00077
196627002789	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
196627002790	dimer interface [polypeptide binding]; other site
196627002791	metal binding site [ion binding]; metal-binding site
196627002792	substrate binding pocket [chemical binding]; other site
196627002793	Septum formation initiator; Region: DivIC; pfam04977
196627002794	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
196627002795	Uncharacterized conserved protein [Function unknown]; Region: COG1507
196627002796	exopolyphosphatase; Region: exo_poly_only; TIGR03706
196627002797	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
196627002798	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
196627002799	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
196627002800	tetramer interface [polypeptide binding]; other site
196627002801	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196627002802	catalytic residue [active]
196627002803	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
196627002804	RibD C-terminal domain; Region: RibD_C; cl17279
196627002805	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
196627002806	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
196627002807	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
196627002808	Predicted membrane protein [Function unknown]; Region: COG4760
196627002809	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
196627002810	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
196627002811	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
196627002812	Domain of unknown function (DUF4307); Region: DUF4307; pfam14155
196627002813	mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446
196627002814	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
196627002815	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
196627002816	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14828
196627002817	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
196627002818	catalytic residue [active]
196627002819	putative FPP diphosphate  binding site; other site
196627002820	putative FPP binding hydrophobic cleft; other site
196627002821	dimer interface [polypeptide binding]; other site
196627002822	putative IPP diphosphate binding site; other site
196627002823	Flavodoxin domain; Region: Flavodoxin_5; pfam12724
196627002824	pantothenate kinase; Provisional; Region: PRK05439
196627002825	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
196627002826	ATP-binding site [chemical binding]; other site
196627002827	CoA-binding site [chemical binding]; other site
196627002828	Mg2+-binding site [ion binding]; other site
196627002829	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
196627002830	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
196627002831	dimer interface [polypeptide binding]; other site
196627002832	active site
196627002833	glycine-pyridoxal phosphate binding site [chemical binding]; other site
196627002834	folate binding site [chemical binding]; other site
196627002835	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
196627002836	Glutamine amidotransferase class-I; Region: GATase; pfam00117
196627002837	glutamine binding [chemical binding]; other site
196627002838	catalytic triad [active]
196627002839	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
196627002840	aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824
196627002841	chorismate binding enzyme; Region: Chorismate_bind; cl10555
196627002842	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
196627002843	substrate-cofactor binding pocket; other site
196627002844	homodimer interface [polypeptide binding]; other site
196627002845	Aminotransferase class IV; Region: Aminotran_4; pfam01063
196627002846	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196627002847	catalytic residue [active]
196627002848	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
196627002849	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
196627002850	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
196627002851	Coenzyme A binding pocket [chemical binding]; other site
196627002852	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
196627002853	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
196627002854	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
196627002855	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
196627002856	putative active site [active]
196627002857	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
196627002858	Transcriptional regulators [Transcription]; Region: FadR; COG2186
196627002859	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
196627002860	DNA-binding site [nucleotide binding]; DNA binding site
196627002861	FCD domain; Region: FCD; pfam07729
196627002862	fumarate hydratase; Reviewed; Region: fumC; PRK00485
196627002863	Class II fumarases; Region: Fumarase_classII; cd01362
196627002864	active site
196627002865	tetramer interface [polypeptide binding]; other site
196627002866	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
196627002867	Predicted flavoprotein [General function prediction only]; Region: COG0431
196627002868	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
196627002869	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
196627002870	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
196627002871	active site
196627002872	non-prolyl cis peptide bond; other site
196627002873	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196627002874	active site
196627002875	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
196627002876	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
196627002877	Flavin binding site [chemical binding]; other site
196627002878	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
196627002879	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
196627002880	active site
196627002881	dimer interface [polypeptide binding]; other site
196627002882	non-prolyl cis peptide bond; other site
196627002883	insertion regions; other site
196627002884	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
196627002885	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
196627002886	putative active site [active]
196627002887	Protein of unknown function (DUF4245); Region: DUF4245; pfam14030
196627002888	VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456
196627002889	metal ion-dependent adhesion site (MIDAS); other site
196627002890	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
196627002891	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
196627002892	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
196627002893	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
196627002894	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
196627002895	generic binding surface II; other site
196627002896	generic binding surface I; other site
196627002897	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
196627002898	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
196627002899	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
196627002900	Membrane protein of unknown function; Region: DUF360; pfam04020
196627002901	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
196627002902	Domain of unknown function DUF20; Region: UPF0118; pfam01594
196627002903	uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334
196627002904	Na2 binding site [ion binding]; other site
196627002905	putative substrate binding site 1 [chemical binding]; other site
196627002906	Na binding site 1 [ion binding]; other site
196627002907	putative substrate binding site 2 [chemical binding]; other site
196627002908	Putative esterase; Region: Esterase; pfam00756
196627002909	GTP-binding protein YchF; Reviewed; Region: PRK09601
196627002910	YchF GTPase; Region: YchF; cd01900
196627002911	G1 box; other site
196627002912	GTP/Mg2+ binding site [chemical binding]; other site
196627002913	Switch I region; other site
196627002914	G2 box; other site
196627002915	Switch II region; other site
196627002916	G3 box; other site
196627002917	G4 box; other site
196627002918	G5 box; other site
196627002919	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
196627002920	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
196627002921	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
196627002922	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
196627002923	non-specific DNA binding site [nucleotide binding]; other site
196627002924	salt bridge; other site
196627002925	sequence-specific DNA binding site [nucleotide binding]; other site
196627002926	Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Region: ArgF; COG0078
196627002927	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
196627002928	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
196627002929	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
196627002930	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
196627002931	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196627002932	active site
196627002933	Transposase; Region: DEDD_Tnp_IS110; pfam01548
196627002934	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
196627002935	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
196627002936	MASE1; Region: MASE1; pfam05231
196627002937	PAS domain S-box; Region: sensory_box; TIGR00229
196627002938	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
196627002939	putative active site [active]
196627002940	heme pocket [chemical binding]; other site
196627002941	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
196627002942	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
196627002943	metal binding site [ion binding]; metal-binding site
196627002944	active site
196627002945	I-site; other site
196627002946	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
196627002947	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
196627002948	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
196627002949	DXD motif; other site
196627002950	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
196627002951	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
196627002952	NNMT/PNMT/TEMT family; Region: NNMT_PNMT_TEMT; pfam01234
196627002953	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
196627002954	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
196627002955	Transposase; Region: DDE_Tnp_ISL3; pfam01610
196627002956	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
196627002957	Transposase; Region: DDE_Tnp_ISL3; pfam01610
196627002958	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
196627002959	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
196627002960	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
196627002961	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
196627002962	active site
196627002963	catalytic tetrad [active]
196627002964	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
196627002965	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
196627002966	NADH(P)-binding; Region: NAD_binding_10; pfam13460
196627002967	NAD(P) binding site [chemical binding]; other site
196627002968	putative active site [active]
196627002969	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
196627002970	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
196627002971	Sulfate transporter family; Region: Sulfate_transp; pfam00916
196627002972	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
196627002973	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196627002974	Walker A/P-loop; other site
196627002975	ATP binding site [chemical binding]; other site
196627002976	Q-loop/lid; other site
196627002977	AMP-binding domain protein; Validated; Region: PRK08315
196627002978	Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867
196627002979	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
196627002980	metal ion-dependent adhesion site (MIDAS); other site
196627002981	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
196627002982	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
196627002983	catalytic core [active]
196627002984	conserved hypothetical protein; Region: TIGR03843
196627002985	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
196627002986	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
196627002987	tetramer interface [polypeptide binding]; other site
196627002988	active site
196627002989	Mg2+/Mn2+ binding site [ion binding]; other site
196627002990	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
196627002991	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196627002992	Walker A/P-loop; other site
196627002993	ATP binding site [chemical binding]; other site
196627002994	Q-loop/lid; other site
196627002995	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
196627002996	ABC transporter; Region: ABC_tran_2; pfam12848
196627002997	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
196627002998	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
196627002999	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
196627003000	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
196627003001	PhnA protein; Region: PhnA; pfam03831
196627003002	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196627003003	putative DNA binding site [nucleotide binding]; other site
196627003004	Transcriptional regulators [Transcription]; Region: MarR; COG1846
196627003005	putative Zn2+ binding site [ion binding]; other site
196627003006	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627003007	Major Facilitator Superfamily; Region: MFS_1; pfam07690
196627003008	putative substrate translocation pore; other site
196627003009	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
196627003010	Transposase; Region: DDE_Tnp_ISL3; pfam01610
196627003011	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
196627003012	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
196627003013	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
196627003014	catalytic residue [active]
196627003015	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543
196627003016	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
196627003017	dimerization interface [polypeptide binding]; other site
196627003018	active site
196627003019	quinolinate synthetase; Provisional; Region: PRK09375
196627003020	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
196627003021	nudix motif; other site
196627003022	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
196627003023	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
196627003024	Protein of unknown function, DUF606; Region: DUF606; pfam04657
196627003025	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
196627003026	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
196627003027	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
196627003028	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
196627003029	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
196627003030	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
196627003031	dimer interface [polypeptide binding]; other site
196627003032	benzoate transport; Region: 2A0115; TIGR00895
196627003033	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627003034	putative substrate translocation pore; other site
196627003035	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627003036	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
196627003037	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
196627003038	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
196627003039	ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721
196627003040	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
196627003041	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
196627003042	Walker A/P-loop; other site
196627003043	ATP binding site [chemical binding]; other site
196627003044	Q-loop/lid; other site
196627003045	ABC transporter signature motif; other site
196627003046	Walker B; other site
196627003047	D-loop; other site
196627003048	H-loop/switch region; other site
196627003049	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
196627003050	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
196627003051	Walker A/P-loop; other site
196627003052	ATP binding site [chemical binding]; other site
196627003053	Q-loop/lid; other site
196627003054	ABC transporter signature motif; other site
196627003055	Walker B; other site
196627003056	D-loop; other site
196627003057	H-loop/switch region; other site
196627003058	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
196627003059	hypothetical protein; Provisional; Region: PRK06547
196627003060	Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563
196627003061	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
196627003062	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
196627003063	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
196627003064	Predicted integral membrane protein [Function unknown]; Region: COG5522
196627003065	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196627003066	Walker A/P-loop; other site
196627003067	ATP binding site [chemical binding]; other site
196627003068	Q-loop/lid; other site
196627003069	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
196627003070	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196627003071	ABC transporter signature motif; other site
196627003072	Walker B; other site
196627003073	D-loop; other site
196627003074	H-loop/switch region; other site
196627003075	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196627003076	Walker A/P-loop; other site
196627003077	ATP binding site [chemical binding]; other site
196627003078	Q-loop/lid; other site
196627003079	ABC transporter signature motif; other site
196627003080	Walker B; other site
196627003081	D-loop; other site
196627003082	H-loop/switch region; other site
196627003083	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
196627003084	dimer interface [polypeptide binding]; other site
196627003085	catalytic triad [active]
196627003086	peroxidatic and resolving cysteines [active]
196627003087	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354
196627003088	2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745
196627003089	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
196627003090	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
196627003091	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424
196627003092	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
196627003093	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
196627003094	nudix motif; other site
196627003095	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
196627003096	Trypsin; Region: Trypsin; pfam00089
196627003097	active site
196627003098	substrate binding sites [chemical binding]; other site
196627003099	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
196627003100	ArsC family; Region: ArsC; pfam03960
196627003101	catalytic residues [active]
196627003102	Uncharacterized membrane protein [Function unknown]; Region: COG3949
196627003103	Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306
196627003104	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
196627003105	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
196627003106	G1 box; other site
196627003107	GTP/Mg2+ binding site [chemical binding]; other site
196627003108	G2 box; other site
196627003109	Switch I region; other site
196627003110	G3 box; other site
196627003111	Switch II region; other site
196627003112	G4 box; other site
196627003113	G5 box; other site
196627003114	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
196627003115	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
196627003116	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
196627003117	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
196627003118	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
196627003119	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
196627003120	Ferredoxin [Energy production and conversion]; Region: COG1146
196627003121	4Fe-4S binding domain; Region: Fer4; pfam00037
196627003122	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
196627003123	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
196627003124	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196627003125	homodimer interface [polypeptide binding]; other site
196627003126	catalytic residue [active]
196627003127	Predicted membrane protein [Function unknown]; Region: COG2246
196627003128	GtrA-like protein; Region: GtrA; pfam04138
196627003129	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
196627003130	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
196627003131	active site
196627003132	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
196627003133	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
196627003134	putative trimer interface [polypeptide binding]; other site
196627003135	putative CoA binding site [chemical binding]; other site
196627003136	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
196627003137	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
196627003138	Tetrahydrodipicolinate N-succinyltransferase [Amino acid transport and metabolism]; Region: DapD; COG2171
196627003139	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
196627003140	putative trimer interface [polypeptide binding]; other site
196627003141	putative CoA binding site [chemical binding]; other site
196627003142	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
196627003143	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
196627003144	metal binding site [ion binding]; metal-binding site
196627003145	putative dimer interface [polypeptide binding]; other site
196627003146	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
196627003147	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
196627003148	dihydropteroate synthase; Region: DHPS; TIGR01496
196627003149	substrate binding pocket [chemical binding]; other site
196627003150	dimer interface [polypeptide binding]; other site
196627003151	inhibitor binding site; inhibition site
196627003152	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
196627003153	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
196627003154	Protein of unknown function (DUF3117); Region: DUF3117; pfam11314
196627003155	Methyltransferase domain; Region: Methyltransf_23; pfam13489
196627003156	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196627003157	S-adenosylmethionine binding site [chemical binding]; other site
196627003158	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
196627003159	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
196627003160	active site
196627003161	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
196627003162	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
196627003163	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
196627003164	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
196627003165	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
196627003166	ligand binding site; other site
196627003167	oligomer interface; other site
196627003168	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
196627003169	sulfate 1 binding site; other site
196627003170	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
196627003171	Methyltransferase domain; Region: Methyltransf_24; pfam13578
196627003172	RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647
196627003173	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
196627003174	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196627003175	DNA binding residues [nucleotide binding]
196627003176	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806
196627003177	sec-independent translocase; Provisional; Region: tatB; PRK00182
196627003178	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
196627003179	Domain of unknown function DUF59; Region: DUF59; pfam01883
196627003180	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
196627003181	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
196627003182	Predicted membrane protein [Function unknown]; Region: COG4420
196627003183	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
196627003184	MgtE intracellular N domain; Region: MgtE_N; smart00924
196627003185	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
196627003186	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
196627003187	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
196627003188	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
196627003189	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
196627003190	TPP-binding site [chemical binding]; other site
196627003191	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
196627003192	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
196627003193	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
196627003194	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196627003195	Walker A/P-loop; other site
196627003196	ATP binding site [chemical binding]; other site
196627003197	Q-loop/lid; other site
196627003198	ABC transporter signature motif; other site
196627003199	Walker B; other site
196627003200	D-loop; other site
196627003201	H-loop/switch region; other site
196627003202	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
196627003203	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
196627003204	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196627003205	Walker A/P-loop; other site
196627003206	ATP binding site [chemical binding]; other site
196627003207	Q-loop/lid; other site
196627003208	ABC transporter signature motif; other site
196627003209	Walker B; other site
196627003210	D-loop; other site
196627003211	H-loop/switch region; other site
196627003212	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
196627003213	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
196627003214	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
196627003215	shikimate binding site; other site
196627003216	NAD(P) binding site [chemical binding]; other site
196627003217	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
196627003218	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
196627003219	substrate binding pocket [chemical binding]; other site
196627003220	catalytic triad [active]
196627003221	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
196627003222	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627003223	putative substrate translocation pore; other site
196627003224	Major Facilitator Superfamily; Region: MFS_1; pfam07690
196627003225	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627003226	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627003227	Major Facilitator Superfamily; Region: MFS_1; pfam07690
196627003228	putative substrate translocation pore; other site
196627003229	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
196627003230	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
196627003231	THF binding site; other site
196627003232	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
196627003233	substrate binding site [chemical binding]; other site
196627003234	THF binding site; other site
196627003235	zinc-binding site [ion binding]; other site
196627003236	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
196627003237	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
196627003238	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
196627003239	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
196627003240	active site
196627003241	nucleophile elbow; other site
196627003242	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
196627003243	Condensation domain; Region: Condensation; pfam00668
196627003244	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
196627003245	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
196627003246	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196627003247	Q-loop/lid; other site
196627003248	ABC transporter signature motif; other site
196627003249	Walker B; other site
196627003250	D-loop; other site
196627003251	H-loop/switch region; other site
196627003252	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
196627003253	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
196627003254	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
196627003255	Walker A/P-loop; other site
196627003256	ATP binding site [chemical binding]; other site
196627003257	Q-loop/lid; other site
196627003258	ABC transporter signature motif; other site
196627003259	Walker B; other site
196627003260	D-loop; other site
196627003261	H-loop/switch region; other site
196627003262	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
196627003263	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
196627003264	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
196627003265	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204
196627003266	PLD-like domain; Region: PLDc_2; pfam13091
196627003267	putative homodimer interface [polypeptide binding]; other site
196627003268	putative active site [active]
196627003269	catalytic site [active]
196627003270	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
196627003271	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196627003272	ATP binding site [chemical binding]; other site
196627003273	putative Mg++ binding site [ion binding]; other site
196627003274	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196627003275	nucleotide binding region [chemical binding]; other site
196627003276	ATP-binding site [chemical binding]; other site
196627003277	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
196627003278	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
196627003279	active site
196627003280	8-oxo-dGMP binding site [chemical binding]; other site
196627003281	nudix motif; other site
196627003282	metal binding site [ion binding]; metal-binding site
196627003283	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
196627003284	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
196627003285	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
196627003286	ATP binding site [chemical binding]; other site
196627003287	Mg++ binding site [ion binding]; other site
196627003288	motif III; other site
196627003289	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196627003290	nucleotide binding region [chemical binding]; other site
196627003291	ATP-binding site [chemical binding]; other site
196627003292	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
196627003293	putative RNA binding site [nucleotide binding]; other site
196627003294	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196627003295	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196627003296	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
196627003297	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
196627003298	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
196627003299	Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177
196627003300	active site
196627003301	dimer interface [polypeptide binding]; other site
196627003302	metal binding site [ion binding]; metal-binding site
196627003303	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
196627003304	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
196627003305	active site
196627003306	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
196627003307	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
196627003308	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
196627003309	Na binding site [ion binding]; other site
196627003310	SNF2 Helicase protein; Region: DUF3670; pfam12419
196627003311	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
196627003312	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196627003313	putative Mg++ binding site [ion binding]; other site
196627003314	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196627003315	nucleotide binding region [chemical binding]; other site
196627003316	ATP-binding site [chemical binding]; other site
196627003317	Uncharacterized conserved protein [Function unknown]; Region: COG4279
196627003318	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
196627003319	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
196627003320	active site
196627003321	metal binding site [ion binding]; metal-binding site
196627003322	DNA binding site [nucleotide binding]
196627003323	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
196627003324	Uncharacterized conserved protein [Function unknown]; Region: COG4717
196627003325	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
196627003326	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
196627003327	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
196627003328	Uncharacterized conserved protein [Function unknown]; Region: COG2353
196627003329	Transcriptional regulators [Transcription]; Region: MarR; COG1846
196627003330	MarR family; Region: MarR_2; pfam12802
196627003331	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
196627003332	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
196627003333	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
196627003334	ligand binding site [chemical binding]; other site
196627003335	flexible hinge region; other site
196627003336	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
196627003337	non-specific DNA interactions [nucleotide binding]; other site
196627003338	DNA binding site [nucleotide binding]
196627003339	sequence specific DNA binding site [nucleotide binding]; other site
196627003340	putative cAMP binding site [chemical binding]; other site
196627003341	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
196627003342	metal-binding site [ion binding]
196627003343	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
196627003344	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
196627003345	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
196627003346	motif II; other site
196627003347	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
196627003348	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
196627003349	synthetase active site [active]
196627003350	NTP binding site [chemical binding]; other site
196627003351	metal binding site [ion binding]; metal-binding site
196627003352	TAP-like protein; Region: Abhydrolase_4; pfam08386
196627003353	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
196627003354	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
196627003355	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
196627003356	active site
196627003357	HIGH motif; other site
196627003358	KMSK motif region; other site
196627003359	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
196627003360	tRNA binding surface [nucleotide binding]; other site
196627003361	anticodon binding site; other site
196627003362	diaminopimelate decarboxylase; Region: lysA; TIGR01048
196627003363	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
196627003364	active site
196627003365	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
196627003366	substrate binding site [chemical binding]; other site
196627003367	catalytic residues [active]
196627003368	dimer interface [polypeptide binding]; other site
196627003369	homoserine dehydrogenase; Provisional; Region: PRK06349
196627003370	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
196627003371	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
196627003372	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
196627003373	homoserine kinase; Provisional; Region: PRK01212
196627003374	Predicted transcriptional regulator [Transcription]; Region: COG2345
196627003375	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
196627003376	Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
196627003377	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
196627003378	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
196627003379	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
196627003380	[4Fe-4S] binding site [ion binding]; other site
196627003381	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
196627003382	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
196627003383	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
196627003384	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
196627003385	molybdopterin cofactor binding site; other site
196627003386	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
196627003387	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
196627003388	MPT binding site; other site
196627003389	trimer interface [polypeptide binding]; other site
196627003390	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
196627003391	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
196627003392	active site
196627003393	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
196627003394	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
196627003395	Domain of unknown function DUF21; Region: DUF21; pfam01595
196627003396	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
196627003397	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
196627003398	Domain of unknown function DUF21; Region: DUF21; pfam01595
196627003399	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
196627003400	Transporter associated domain; Region: CorC_HlyC; pfam03471
196627003401	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
196627003402	GTP binding site; other site
196627003403	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
196627003404	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
196627003405	dimer interface [polypeptide binding]; other site
196627003406	putative functional site; other site
196627003407	putative MPT binding site; other site
196627003408	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
196627003409	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
196627003410	FeS/SAM binding site; other site
196627003411	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
196627003412	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620
196627003413	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
196627003414	dimer interface [polypeptide binding]; other site
196627003415	acyl-activating enzyme (AAE) consensus motif; other site
196627003416	putative active site [active]
196627003417	AMP binding site [chemical binding]; other site
196627003418	putative CoA binding site [chemical binding]; other site
196627003419	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
196627003420	transcription termination factor Rho; Provisional; Region: PRK12608
196627003421	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
196627003422	RNA binding site [nucleotide binding]; other site
196627003423	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
196627003424	multimer interface [polypeptide binding]; other site
196627003425	Walker A motif; other site
196627003426	ATP binding site [chemical binding]; other site
196627003427	Walker B motif; other site
196627003428	peptide chain release factor 1; Validated; Region: prfA; PRK00591
196627003429	This domain is found in peptide chain release factors; Region: PCRF; smart00937
196627003430	RF-1 domain; Region: RF-1; pfam00472
196627003431	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
196627003432	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196627003433	S-adenosylmethionine binding site [chemical binding]; other site
196627003434	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
196627003435	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
196627003436	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
196627003437	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
196627003438	Mg++ binding site [ion binding]; other site
196627003439	putative catalytic motif [active]
196627003440	substrate binding site [chemical binding]; other site
196627003441	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
196627003442	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
196627003443	F0F1 ATP synthase subunit C; Validated; Region: PRK07874
196627003444	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
196627003445	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
196627003446	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430
196627003447	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
196627003448	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
196627003449	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
196627003450	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
196627003451	beta subunit interaction interface [polypeptide binding]; other site
196627003452	Walker A motif; other site
196627003453	ATP binding site [chemical binding]; other site
196627003454	Walker B motif; other site
196627003455	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
196627003456	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
196627003457	core domain interface [polypeptide binding]; other site
196627003458	delta subunit interface [polypeptide binding]; other site
196627003459	epsilon subunit interface [polypeptide binding]; other site
196627003460	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
196627003461	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
196627003462	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
196627003463	alpha subunit interaction interface [polypeptide binding]; other site
196627003464	Walker A motif; other site
196627003465	ATP binding site [chemical binding]; other site
196627003466	Walker B motif; other site
196627003467	inhibitor binding site; inhibition site
196627003468	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
196627003469	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
196627003470	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
196627003471	gamma subunit interface [polypeptide binding]; other site
196627003472	epsilon subunit interface [polypeptide binding]; other site
196627003473	LBP interface [polypeptide binding]; other site
196627003474	Protein of unknown function (DUF2550); Region: DUF2550; pfam10739
196627003475	Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637
196627003476	hypothetical protein; Provisional; Region: PRK03298
196627003477	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
196627003478	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
196627003479	dimer interface [polypeptide binding]; other site
196627003480	substrate binding site [chemical binding]; other site
196627003481	metal binding site [ion binding]; metal-binding site
196627003482	Uncharacterized conserved protein [Function unknown]; Region: COG0011
196627003483	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
196627003484	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
196627003485	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
196627003486	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
196627003487	dimer interface [polypeptide binding]; other site
196627003488	active site
196627003489	non-prolyl cis peptide bond; other site
196627003490	insertion regions; other site
196627003491	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
196627003492	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196627003493	dimer interface [polypeptide binding]; other site
196627003494	conserved gate region; other site
196627003495	putative PBP binding loops; other site
196627003496	ABC-ATPase subunit interface; other site
196627003497	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
196627003498	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
196627003499	Walker A/P-loop; other site
196627003500	ATP binding site [chemical binding]; other site
196627003501	Q-loop/lid; other site
196627003502	ABC transporter signature motif; other site
196627003503	Walker B; other site
196627003504	D-loop; other site
196627003505	H-loop/switch region; other site
196627003506	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
196627003507	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
196627003508	substrate binding pocket [chemical binding]; other site
196627003509	membrane-bound complex binding site; other site
196627003510	hinge residues; other site
196627003511	Domain of unknown function (DUF4303); Region: DUF4303; pfam14136
196627003512	glycogen branching enzyme; Provisional; Region: PRK05402
196627003513	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
196627003514	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
196627003515	active site
196627003516	catalytic site [active]
196627003517	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
196627003518	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
196627003519	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
196627003520	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
196627003521	active site
196627003522	catalytic site [active]
196627003523	ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119
196627003524	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196627003525	Walker A/P-loop; other site
196627003526	ATP binding site [chemical binding]; other site
196627003527	Q-loop/lid; other site
196627003528	ABC transporter signature motif; other site
196627003529	Walker B; other site
196627003530	D-loop; other site
196627003531	H-loop/switch region; other site
196627003532	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
196627003533	Ligand binding site [chemical binding]; other site
196627003534	Electron transfer flavoprotein domain; Region: ETF; pfam01012
196627003535	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
196627003536	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
196627003537	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
196627003538	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
196627003539	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
196627003540	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
196627003541	catalytic residue [active]
196627003542	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
196627003543	HipA N-terminal domain; Region: couple_hipA; TIGR03071
196627003544	HipA-like N-terminal domain; Region: HipA_N; pfam07805
196627003545	HipA-like C-terminal domain; Region: HipA_C; pfam07804
196627003546	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
196627003547	salt bridge; other site
196627003548	non-specific DNA binding site [nucleotide binding]; other site
196627003549	sequence-specific DNA binding site [nucleotide binding]; other site
196627003550	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
196627003551	Coenzyme A binding pocket [chemical binding]; other site
196627003552	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196627003553	S-adenosylmethionine binding site [chemical binding]; other site
196627003554	AAA ATPase domain; Region: AAA_16; pfam13191
196627003555	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
196627003556	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
196627003557	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
196627003558	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
196627003559	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627003560	Major Facilitator Superfamily; Region: MFS_1; pfam07690
196627003561	putative substrate translocation pore; other site
196627003562	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627003563	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
196627003564	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
196627003565	active site
196627003566	catalytic site [active]
196627003567	substrate binding site [chemical binding]; other site
196627003568	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
196627003569	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
196627003570	nucleotide binding pocket [chemical binding]; other site
196627003571	K-X-D-G motif; other site
196627003572	catalytic site [active]
196627003573	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
196627003574	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
196627003575	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
196627003576	Dimer interface [polypeptide binding]; other site
196627003577	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
196627003578	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
196627003579	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
196627003580	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
196627003581	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
196627003582	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
196627003583	FAD binding pocket [chemical binding]; other site
196627003584	FAD binding motif [chemical binding]; other site
196627003585	phosphate binding motif [ion binding]; other site
196627003586	NAD binding pocket [chemical binding]; other site
196627003587	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
196627003588	phosphofructokinase; Region: PFK_mixed; TIGR02483
196627003589	active site
196627003590	ADP/pyrophosphate binding site [chemical binding]; other site
196627003591	dimerization interface [polypeptide binding]; other site
196627003592	allosteric effector site; other site
196627003593	fructose-1,6-bisphosphate binding site; other site
196627003594	Transcriptional regulators [Transcription]; Region: PurR; COG1609
196627003595	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
196627003596	DNA binding site [nucleotide binding]
196627003597	domain linker motif; other site
196627003598	Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299
196627003599	dimerization interface [polypeptide binding]; other site
196627003600	putative ligand binding site [chemical binding]; other site
196627003601	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
196627003602	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
196627003603	Walker A/P-loop; other site
196627003604	ATP binding site [chemical binding]; other site
196627003605	Q-loop/lid; other site
196627003606	ABC transporter signature motif; other site
196627003607	Walker B; other site
196627003608	D-loop; other site
196627003609	H-loop/switch region; other site
196627003610	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
196627003611	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
196627003612	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
196627003613	TM-ABC transporter signature motif; other site
196627003614	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
196627003615	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
196627003616	ligand binding site [chemical binding]; other site
196627003617	dimerization interface [polypeptide binding]; other site
196627003618	D-ribose pyranase; Provisional; Region: PRK11797
196627003619	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
196627003620	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
196627003621	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
196627003622	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
196627003623	siderophore binding site; other site
196627003624	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
196627003625	Sodium Bile acid symporter family; Region: SBF; pfam01758
196627003626	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
196627003627	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
196627003628	GatB domain; Region: GatB_Yqey; pfam02637
196627003629	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
196627003630	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
196627003631	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
196627003632	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
196627003633	active site
196627003634	catalytic tetrad [active]
196627003635	L-lysine exporter; Region: 2a75; TIGR00948
196627003636	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
196627003637	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
196627003638	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
196627003639	dimerization interface [polypeptide binding]; other site
196627003640	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
196627003641	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
196627003642	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
196627003643	putative dimer interface [polypeptide binding]; other site
196627003644	N-terminal domain interface [polypeptide binding]; other site
196627003645	putative substrate binding pocket (H-site) [chemical binding]; other site
196627003646	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
196627003647	Predicted membrane protein [Function unknown]; Region: COG2259
196627003648	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
196627003649	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
196627003650	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
196627003651	Mechanosensitive ion channel; Region: MS_channel; pfam00924
196627003652	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
196627003653	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
196627003654	PYR/PP interface [polypeptide binding]; other site
196627003655	dimer interface [polypeptide binding]; other site
196627003656	TPP binding site [chemical binding]; other site
196627003657	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
196627003658	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
196627003659	TPP-binding site [chemical binding]; other site
196627003660	dimer interface [polypeptide binding]; other site
196627003661	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
196627003662	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
196627003663	putative valine binding site [chemical binding]; other site
196627003664	dimer interface [polypeptide binding]; other site
196627003665	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
196627003666	ketol-acid reductoisomerase; Provisional; Region: PRK05479
196627003667	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
196627003668	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
196627003669	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
196627003670	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196627003671	ABC transporter signature motif; other site
196627003672	Walker B; other site
196627003673	D-loop; other site
196627003674	H-loop/switch region; other site
196627003675	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
196627003676	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196627003677	Walker A/P-loop; other site
196627003678	ATP binding site [chemical binding]; other site
196627003679	Q-loop/lid; other site
196627003680	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
196627003681	NMT1-like family; Region: NMT1_2; pfam13379
196627003682	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
196627003683	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
196627003684	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
196627003685	Uncharacterized conserved protein [Function unknown]; Region: COG1479
196627003686	Protein of unknown function DUF262; Region: DUF262; pfam03235
196627003687	Uncharacterized conserved protein [Function unknown]; Region: COG3472
196627003688	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
196627003689	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
196627003690	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
196627003691	ligand binding site [chemical binding]; other site
196627003692	NAD binding site [chemical binding]; other site
196627003693	dimerization interface [polypeptide binding]; other site
196627003694	catalytic site [active]
196627003695	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
196627003696	putative L-serine binding site [chemical binding]; other site
196627003697	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
196627003698	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
196627003699	tartrate dehydrogenase; Region: TTC; TIGR02089
196627003700	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
196627003701	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
196627003702	membrane-bound complex binding site; other site
196627003703	hinge residues; other site
196627003704	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
196627003705	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
196627003706	ligand binding site [chemical binding]; other site
196627003707	flexible hinge region; other site
196627003708	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
196627003709	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
196627003710	metal binding triad; other site
196627003711	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
196627003712	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
196627003713	active site
196627003714	catalytic site [active]
196627003715	substrate binding site [chemical binding]; other site
196627003716	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
196627003717	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
196627003718	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
196627003719	Methyltransferase domain; Region: Methyltransf_23; pfam13489
196627003720	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196627003721	S-adenosylmethionine binding site [chemical binding]; other site
196627003722	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
196627003723	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
196627003724	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
196627003725	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
196627003726	active site
196627003727	HIGH motif; other site
196627003728	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
196627003729	active site
196627003730	KMSKS motif; other site
196627003731	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
196627003732	salt bridge; other site
196627003733	non-specific DNA binding site [nucleotide binding]; other site
196627003734	sequence-specific DNA binding site [nucleotide binding]; other site
196627003735	Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
196627003736	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822
196627003737	putative hydrophobic ligand binding site [chemical binding]; other site
196627003738	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196627003739	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196627003740	WHG domain; Region: WHG; pfam13305
196627003741	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822
196627003742	putative hydrophobic ligand binding site [chemical binding]; other site
196627003743	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
196627003744	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
196627003745	ThiC-associated domain; Region: ThiC-associated; pfam13667
196627003746	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
196627003747	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
196627003748	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
196627003749	homodimer interface [polypeptide binding]; other site
196627003750	active site pocket [active]
196627003751	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
196627003752	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
196627003753	active site residue [active]
196627003754	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
196627003755	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
196627003756	HD domain; Region: HD_4; pfam13328
196627003757	Transcriptional regulator [Transcription]; Region: IclR; COG1414
196627003758	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
196627003759	Bacterial transcriptional regulator; Region: IclR; pfam01614
196627003760	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
196627003761	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
196627003762	substrate binding site [chemical binding]; other site
196627003763	ligand binding site [chemical binding]; other site
196627003764	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
196627003765	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
196627003766	substrate binding site [chemical binding]; other site
196627003767	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
196627003768	active site
196627003769	Ap6A binding site [chemical binding]; other site
196627003770	nudix motif; other site
196627003771	metal binding site [ion binding]; metal-binding site
196627003772	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
196627003773	catalytic core [active]
196627003774	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
196627003775	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
196627003776	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
196627003777	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
196627003778	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
196627003779	ATP-grasp domain; Region: ATP-grasp_4; cl17255
196627003780	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
196627003781	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
196627003782	thiamine monophosphate kinase; Provisional; Region: PRK05731
196627003783	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
196627003784	ATP binding site [chemical binding]; other site
196627003785	dimerization interface [polypeptide binding]; other site
196627003786	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
196627003787	ligand binding site [chemical binding]; other site
196627003788	active site
196627003789	UGI interface [polypeptide binding]; other site
196627003790	catalytic site [active]
196627003791	Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461
196627003792	DAK2 domain; Region: Dak2; pfam02734
196627003793	RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200
196627003794	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
196627003795	generic binding surface II; other site
196627003796	ssDNA binding site; other site
196627003797	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196627003798	ATP binding site [chemical binding]; other site
196627003799	putative Mg++ binding site [ion binding]; other site
196627003800	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196627003801	nucleotide binding region [chemical binding]; other site
196627003802	ATP-binding site [chemical binding]; other site
196627003803	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
196627003804	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
196627003805	carboxyltransferase (CT) interaction site; other site
196627003806	biotinylation site [posttranslational modification]; other site
196627003807	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
196627003808	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196627003809	S-adenosylmethionine binding site [chemical binding]; other site
196627003810	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
196627003811	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
196627003812	active site
196627003813	(T/H)XGH motif; other site
196627003814	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
196627003815	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
196627003816	Walker A/P-loop; other site
196627003817	ATP binding site [chemical binding]; other site
196627003818	Q-loop/lid; other site
196627003819	ABC transporter signature motif; other site
196627003820	Walker B; other site
196627003821	D-loop; other site
196627003822	H-loop/switch region; other site
196627003823	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196627003824	dimer interface [polypeptide binding]; other site
196627003825	conserved gate region; other site
196627003826	putative PBP binding loops; other site
196627003827	ABC-ATPase subunit interface; other site
196627003828	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
196627003829	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
196627003830	substrate binding pocket [chemical binding]; other site
196627003831	membrane-bound complex binding site; other site
196627003832	hinge residues; other site
196627003833	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
196627003834	Domain of unknown function (DUF368); Region: DUF368; pfam04018
196627003835	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
196627003836	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
196627003837	active site
196627003838	DNA binding site [nucleotide binding]
196627003839	Int/Topo IB signature motif; other site
196627003840	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
196627003841	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4815
196627003842	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
196627003843	Uncharacterized conserved small protein [Function unknown]; Region: COG5428
196627003844	Integrase core domain; Region: rve_3; cl15866
196627003845	Integrase core domain; Region: rve_3; cl15866
196627003846	putative assembly protein; Provisional; Region: PRK10833
196627003847	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
196627003848	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
196627003849	DNA polymerase I; Provisional; Region: PRK05755
196627003850	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
196627003851	active site
196627003852	metal binding site 1 [ion binding]; metal-binding site
196627003853	putative 5' ssDNA interaction site; other site
196627003854	metal binding site 3; metal-binding site
196627003855	metal binding site 2 [ion binding]; metal-binding site
196627003856	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
196627003857	putative DNA binding site [nucleotide binding]; other site
196627003858	putative metal binding site [ion binding]; other site
196627003859	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
196627003860	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
196627003861	active site
196627003862	DNA binding site [nucleotide binding]
196627003863	catalytic site [active]
196627003864	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627003865	Major Facilitator Superfamily; Region: MFS_1; pfam07690
196627003866	putative substrate translocation pore; other site
196627003867	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627003868	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
196627003869	salt bridge; other site
196627003870	non-specific DNA binding site [nucleotide binding]; other site
196627003871	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
196627003872	sequence-specific DNA binding site [nucleotide binding]; other site
196627003873	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
196627003874	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
196627003875	active site
196627003876	catalytic tetrad [active]
196627003877	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
196627003878	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196627003879	S-adenosylmethionine binding site [chemical binding]; other site
196627003880	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
196627003881	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
196627003882	RNA binding site [nucleotide binding]; other site
196627003883	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
196627003884	RNA binding site [nucleotide binding]; other site
196627003885	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
196627003886	RNA binding site [nucleotide binding]; other site
196627003887	S1 RNA binding domain; Region: S1; pfam00575
196627003888	RNA binding site [nucleotide binding]; other site
196627003889	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
196627003890	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
196627003891	active site turn [active]
196627003892	phosphorylation site [posttranslational modification]
196627003893	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
196627003894	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
196627003895	HPr interaction site; other site
196627003896	glycerol kinase (GK) interaction site [polypeptide binding]; other site
196627003897	active site
196627003898	phosphorylation site [posttranslational modification]
196627003899	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
196627003900	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
196627003901	CoA-binding site [chemical binding]; other site
196627003902	ATP-binding [chemical binding]; other site
196627003903	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
196627003904	active site
196627003905	tetramer interface [polypeptide binding]; other site
196627003906	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
196627003907	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627003908	putative substrate translocation pore; other site
196627003909	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
196627003910	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
196627003911	substrate binding site [chemical binding]; other site
196627003912	dimer interface [polypeptide binding]; other site
196627003913	ATP binding site [chemical binding]; other site
196627003914	Transcriptional regulators [Transcription]; Region: PurR; COG1609
196627003915	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
196627003916	DNA binding site [nucleotide binding]
196627003917	domain linker motif; other site
196627003918	Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299
196627003919	dimerization interface [polypeptide binding]; other site
196627003920	putative ligand binding site [chemical binding]; other site
196627003921	excinuclease ABC subunit B; Provisional; Region: PRK05298
196627003922	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196627003923	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196627003924	nucleotide binding region [chemical binding]; other site
196627003925	ATP-binding site [chemical binding]; other site
196627003926	Ultra-violet resistance protein B; Region: UvrB; pfam12344
196627003927	UvrB/uvrC motif; Region: UVR; pfam02151
196627003928	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
196627003929	Ligand Binding Site [chemical binding]; other site
196627003930	Predicted transcriptional regulators [Transcription]; Region: COG1733
196627003931	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
196627003932	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
196627003933	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
196627003934	NADP binding site [chemical binding]; other site
196627003935	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
196627003936	Part of AAA domain; Region: AAA_19; pfam13245
196627003937	Family description; Region: UvrD_C_2; pfam13538
196627003938	Predicted membrane protein [Function unknown]; Region: COG2259
196627003939	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
196627003940	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
196627003941	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
196627003942	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
196627003943	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
196627003944	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
196627003945	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
196627003946	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
196627003947	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
196627003948	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
196627003949	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
196627003950	23S rRNA binding site [nucleotide binding]; other site
196627003951	L21 binding site [polypeptide binding]; other site
196627003952	L13 binding site [polypeptide binding]; other site
196627003953	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446
196627003954	GIY-YIG motif/motif A; other site
196627003955	putative active site [active]
196627003956	putative metal binding site [ion binding]; other site
196627003957	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196627003958	dimer interface [polypeptide binding]; other site
196627003959	conserved gate region; other site
196627003960	putative PBP binding loops; other site
196627003961	ABC-ATPase subunit interface; other site
196627003962	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
196627003963	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196627003964	dimer interface [polypeptide binding]; other site
196627003965	conserved gate region; other site
196627003966	putative PBP binding loops; other site
196627003967	ABC-ATPase subunit interface; other site
196627003968	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
196627003969	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
196627003970	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
196627003971	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
196627003972	Walker A/P-loop; other site
196627003973	ATP binding site [chemical binding]; other site
196627003974	Q-loop/lid; other site
196627003975	ABC transporter signature motif; other site
196627003976	Walker B; other site
196627003977	D-loop; other site
196627003978	H-loop/switch region; other site
196627003979	TOBE domain; Region: TOBE_2; pfam08402
196627003980	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
196627003981	Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
196627003982	active site
196627003983	catalytic site [active]
196627003984	metal binding site [ion binding]; metal-binding site
196627003985	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
196627003986	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
196627003987	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
196627003988	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
196627003989	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
196627003990	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
196627003991	dimer interface [polypeptide binding]; other site
196627003992	motif 1; other site
196627003993	active site
196627003994	motif 2; other site
196627003995	motif 3; other site
196627003996	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
196627003997	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
196627003998	putative tRNA-binding site [nucleotide binding]; other site
196627003999	B3/4 domain; Region: B3_4; pfam03483
196627004000	tRNA synthetase B5 domain; Region: B5; smart00874
196627004001	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
196627004002	dimer interface [polypeptide binding]; other site
196627004003	motif 1; other site
196627004004	motif 3; other site
196627004005	motif 2; other site
196627004006	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
196627004007	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
196627004008	active site
196627004009	catalytic triad [active]
196627004010	oxyanion hole [active]
196627004011	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
196627004012	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
196627004013	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
196627004014	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
196627004015	heterotetramer interface [polypeptide binding]; other site
196627004016	active site pocket [active]
196627004017	cleavage site
196627004018	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
196627004019	feedback inhibition sensing region; other site
196627004020	homohexameric interface [polypeptide binding]; other site
196627004021	nucleotide binding site [chemical binding]; other site
196627004022	N-acetyl-L-glutamate binding site [chemical binding]; other site
196627004023	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
196627004024	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
196627004025	inhibitor-cofactor binding pocket; inhibition site
196627004026	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196627004027	catalytic residue [active]
196627004028	ornithine carbamoyltransferase; Provisional; Region: PRK00779
196627004029	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
196627004030	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
196627004031	arginine repressor; Provisional; Region: PRK03341
196627004032	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
196627004033	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
196627004034	argininosuccinate synthase; Provisional; Region: PRK13820
196627004035	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
196627004036	ANP binding site [chemical binding]; other site
196627004037	Substrate Binding Site II [chemical binding]; other site
196627004038	Substrate Binding Site I [chemical binding]; other site
196627004039	argininosuccinate lyase; Provisional; Region: PRK00855
196627004040	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
196627004041	active sites [active]
196627004042	tetramer interface [polypeptide binding]; other site
196627004043	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
196627004044	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
196627004045	metal ion-dependent adhesion site (MIDAS); other site
196627004046	Uncharacterized conserved protein [Function unknown]; Region: COG2835
196627004047	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
196627004048	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
196627004049	active site
196627004050	HIGH motif; other site
196627004051	dimer interface [polypeptide binding]; other site
196627004052	KMSKS motif; other site
196627004053	S4 RNA-binding domain; Region: S4; smart00363
196627004054	RNA binding surface [nucleotide binding]; other site
196627004055	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
196627004056	Ligand Binding Site [chemical binding]; other site
196627004057	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
196627004058	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
196627004059	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
196627004060	active site
196627004061	motif I; other site
196627004062	motif II; other site
196627004063	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
196627004064	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
196627004065	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
196627004066	RNA binding surface [nucleotide binding]; other site
196627004067	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196627004068	S-adenosylmethionine binding site [chemical binding]; other site
196627004069	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372
196627004070	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
196627004071	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
196627004072	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
196627004073	Walker A/P-loop; other site
196627004074	ATP binding site [chemical binding]; other site
196627004075	Q-loop/lid; other site
196627004076	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
196627004077	ABC transporter signature motif; other site
196627004078	Walker B; other site
196627004079	D-loop; other site
196627004080	H-loop/switch region; other site
196627004081	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
196627004082	Thiamine pyrophosphokinase; Region: TPK; cl08415
196627004083	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
196627004084	CTP synthetase; Validated; Region: pyrG; PRK05380
196627004085	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
196627004086	Catalytic site [active]
196627004087	active site
196627004088	UTP binding site [chemical binding]; other site
196627004089	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
196627004090	active site
196627004091	putative oxyanion hole; other site
196627004092	catalytic triad [active]
196627004093	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
196627004094	dimer interface [polypeptide binding]; other site
196627004095	ADP-ribose binding site [chemical binding]; other site
196627004096	active site
196627004097	nudix motif; other site
196627004098	metal binding site [ion binding]; metal-binding site
196627004099	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
196627004100	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
196627004101	active site
196627004102	Int/Topo IB signature motif; other site
196627004103	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
196627004104	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196627004105	Walker A/P-loop; other site
196627004106	ATP binding site [chemical binding]; other site
196627004107	Q-loop/lid; other site
196627004108	ABC transporter signature motif; other site
196627004109	Walker B; other site
196627004110	D-loop; other site
196627004111	H-loop/switch region; other site
196627004112	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
196627004113	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
196627004114	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
196627004115	P-loop; other site
196627004116	Magnesium ion binding site [ion binding]; other site
196627004117	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
196627004118	Magnesium ion binding site [ion binding]; other site
196627004119	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
196627004120	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
196627004121	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
196627004122	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
196627004123	active site residue [active]
196627004124	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
196627004125	active site residue [active]
196627004126	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
196627004127	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
196627004128	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
196627004129	RNA binding surface [nucleotide binding]; other site
196627004130	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
196627004131	active site
196627004132	cytidylate kinase; Provisional; Region: cmk; PRK00023
196627004133	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
196627004134	CMP-binding site; other site
196627004135	The sites determining sugar specificity; other site
196627004136	GTP-binding protein Der; Reviewed; Region: PRK03003
196627004137	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
196627004138	G1 box; other site
196627004139	GTP/Mg2+ binding site [chemical binding]; other site
196627004140	Switch I region; other site
196627004141	G2 box; other site
196627004142	Switch II region; other site
196627004143	G3 box; other site
196627004144	G4 box; other site
196627004145	G5 box; other site
196627004146	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
196627004147	G1 box; other site
196627004148	GTP/Mg2+ binding site [chemical binding]; other site
196627004149	Switch I region; other site
196627004150	G2 box; other site
196627004151	G3 box; other site
196627004152	Switch II region; other site
196627004153	G4 box; other site
196627004154	G5 box; other site
196627004155	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
196627004156	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
196627004157	Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978
196627004158	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196627004159	S-adenosylmethionine binding site [chemical binding]; other site
196627004160	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
196627004161	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
196627004162	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196627004163	Walker B; other site
196627004164	D-loop; other site
196627004165	H-loop/switch region; other site
196627004166	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
196627004167	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
196627004168	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196627004169	Walker A/P-loop; other site
196627004170	ATP binding site [chemical binding]; other site
196627004171	Q-loop/lid; other site
196627004172	ABC transporter signature motif; other site
196627004173	Walker B; other site
196627004174	D-loop; other site
196627004175	H-loop/switch region; other site
196627004176	zinc transporter ZupT; Provisional; Region: PRK04201
196627004177	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
196627004178	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012
196627004179	SEC-C motif; Region: SEC-C; pfam02810
196627004180	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
196627004181	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
196627004182	preprotein translocase subunit SecA; Reviewed; Region: PRK12326
196627004183	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
196627004184	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
196627004185	nucleotide binding region [chemical binding]; other site
196627004186	ATP-binding site [chemical binding]; other site
196627004187	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
196627004188	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
196627004189	phosphopeptide binding site; other site
196627004190	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
196627004191	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
196627004192	DNA binding residues [nucleotide binding]
196627004193	Uncharacterized conserved protein [Function unknown]; Region: COG1259
196627004194	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
196627004195	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
196627004196	DNA binding residues [nucleotide binding]
196627004197	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
196627004198	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
196627004199	Domain of unknown function DUF21; Region: DUF21; pfam01595
196627004200	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
196627004201	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
196627004202	Domain of unknown function DUF21; Region: DUF21; pfam01595
196627004203	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
196627004204	Transporter associated domain; Region: CorC_HlyC; smart01091
196627004205	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
196627004206	DEAD-like helicases superfamily; Region: DEXDc; smart00487
196627004207	ATP binding site [chemical binding]; other site
196627004208	putative Mg++ binding site [ion binding]; other site
196627004209	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196627004210	nucleotide binding region [chemical binding]; other site
196627004211	ATP-binding site [chemical binding]; other site
196627004212	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
196627004213	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
196627004214	FAD binding pocket [chemical binding]; other site
196627004215	FAD binding motif [chemical binding]; other site
196627004216	phosphate binding motif [ion binding]; other site
196627004217	NAD binding pocket [chemical binding]; other site
196627004218	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
196627004219	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
196627004220	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
196627004221	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
196627004222	CoenzymeA binding site [chemical binding]; other site
196627004223	subunit interaction site [polypeptide binding]; other site
196627004224	PHB binding site; other site
196627004225	Methyltransferase domain; Region: Methyltransf_31; pfam13847
196627004226	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196627004227	S-adenosylmethionine binding site [chemical binding]; other site
196627004228	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
196627004229	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
196627004230	Walker A/P-loop; other site
196627004231	ATP binding site [chemical binding]; other site
196627004232	Q-loop/lid; other site
196627004233	ABC transporter signature motif; other site
196627004234	Walker B; other site
196627004235	D-loop; other site
196627004236	H-loop/switch region; other site
196627004237	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
196627004238	ABC-2 type transporter; Region: ABC2_membrane; cl17235
196627004239	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
196627004240	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
196627004241	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
196627004242	putative active site [active]
196627004243	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
196627004244	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196627004245	dimer interface [polypeptide binding]; other site
196627004246	conserved gate region; other site
196627004247	ABC-ATPase subunit interface; other site
196627004248	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
196627004249	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196627004250	dimer interface [polypeptide binding]; other site
196627004251	conserved gate region; other site
196627004252	ABC-ATPase subunit interface; other site
196627004253	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
196627004254	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
196627004255	Walker A/P-loop; other site
196627004256	ATP binding site [chemical binding]; other site
196627004257	Q-loop/lid; other site
196627004258	ABC transporter signature motif; other site
196627004259	Walker B; other site
196627004260	D-loop; other site
196627004261	H-loop/switch region; other site
196627004262	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
196627004263	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
196627004264	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
196627004265	motif I; other site
196627004266	active site
196627004267	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
196627004268	motif II; other site
196627004269	multifunctional thiamine-phosphate pyrophosphorylase/synthase/phosphomethylpyrimidine kinase; Provisional; Region: PRK09517
196627004270	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
196627004271	thiamine phosphate binding site [chemical binding]; other site
196627004272	active site
196627004273	pyrophosphate binding site [ion binding]; other site
196627004274	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
196627004275	dimer interface [polypeptide binding]; other site
196627004276	substrate binding site [chemical binding]; other site
196627004277	ATP binding site [chemical binding]; other site
196627004278	Putative transcription activator [Transcription]; Region: TenA; COG0819
196627004279	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
196627004280	substrate binding site [chemical binding]; other site
196627004281	multimerization interface [polypeptide binding]; other site
196627004282	ATP binding site [chemical binding]; other site
196627004283	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
196627004284	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
196627004285	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
196627004286	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
196627004287	metabolite-proton symporter; Region: 2A0106; TIGR00883
196627004288	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627004289	putative substrate translocation pore; other site
196627004290	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
196627004291	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
196627004292	active site
196627004293	Predicted membrane protein [Function unknown]; Region: COG1971
196627004294	Domain of unknown function DUF; Region: DUF204; pfam02659
196627004295	Domain of unknown function DUF; Region: DUF204; pfam02659
196627004296	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
196627004297	Sodium Bile acid symporter family; Region: SBF; cl17470
196627004298	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
196627004299	A new structural DNA glycosylase; Region: AlkD_like; cd06561
196627004300	active site
196627004301	high affinity sulphate transporter 1; Region: sulP; TIGR00815
196627004302	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
196627004303	Sulfate transporter family; Region: Sulfate_transp; pfam00916
196627004304	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
196627004305	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
196627004306	YceI-like domain; Region: YceI; cl01001
196627004307	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
196627004308	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
196627004309	Ligand binding site; other site
196627004310	Putative Catalytic site; other site
196627004311	DXD motif; other site
196627004312	Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
196627004313	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
196627004314	putative active site [active]
196627004315	catalytic triad [active]
196627004316	putative dimer interface [polypeptide binding]; other site
196627004317	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
196627004318	Secretory lipase; Region: LIP; pfam03583
196627004319	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
196627004320	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
196627004321	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
196627004322	active site
196627004323	putative homodimer interface [polypeptide binding]; other site
196627004324	SAM binding site [chemical binding]; other site
196627004325	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
196627004326	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
196627004327	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
196627004328	classical (c) SDRs; Region: SDR_c; cd05233
196627004329	NAD(P) binding site [chemical binding]; other site
196627004330	active site
196627004331	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
196627004332	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
196627004333	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
196627004334	active site
196627004335	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
196627004336	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
196627004337	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
196627004338	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196627004339	ATP binding site [chemical binding]; other site
196627004340	putative Mg++ binding site [ion binding]; other site
196627004341	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196627004342	nucleotide binding region [chemical binding]; other site
196627004343	ATP-binding site [chemical binding]; other site
196627004344	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
196627004345	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
196627004346	twin arginine translocase protein A; Provisional; Region: tatA; PRK00191
196627004347	mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416
196627004348	Predicted transcriptional regulator [Transcription]; Region: COG2378
196627004349	WYL domain; Region: WYL; pfam13280
196627004350	Predicted transcriptional regulator [Transcription]; Region: COG2378
196627004351	WYL domain; Region: WYL; pfam13280
196627004352	proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686
196627004353	Pup-like protein; Region: Pup; pfam05639
196627004354	proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688
196627004355	proteasome ATPase; Region: pup_AAA; TIGR03689
196627004356	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196627004357	Walker A motif; other site
196627004358	ATP binding site [chemical binding]; other site
196627004359	Walker B motif; other site
196627004360	arginine finger; other site
196627004361	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
196627004362	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196627004363	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
196627004364	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
196627004365	active site
196627004366	metal binding site [ion binding]; metal-binding site
196627004367	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
196627004368	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
196627004369	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
196627004370	non-specific DNA binding site [nucleotide binding]; other site
196627004371	salt bridge; other site
196627004372	sequence-specific DNA binding site [nucleotide binding]; other site
196627004373	Major Facilitator Superfamily; Region: MFS_1; pfam07690
196627004374	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627004375	putative substrate translocation pore; other site
196627004376	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
196627004377	Aspartase; Region: Aspartase; cd01357
196627004378	active sites [active]
196627004379	tetramer interface [polypeptide binding]; other site
196627004380	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
196627004381	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
196627004382	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
196627004383	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
196627004384	homodimer interface [polypeptide binding]; other site
196627004385	putative metal binding site [ion binding]; other site
196627004386	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
196627004387	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
196627004388	motif II; other site
196627004389	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
196627004390	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
196627004391	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
196627004392	substrate binding pocket [chemical binding]; other site
196627004393	dimer interface [polypeptide binding]; other site
196627004394	inhibitor binding site; inhibition site
196627004395	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
196627004396	B12 binding site [chemical binding]; other site
196627004397	cobalt ligand [ion binding]; other site
196627004398	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
196627004399	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
196627004400	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
196627004401	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196627004402	dimerization interface [polypeptide binding]; other site
196627004403	putative DNA binding site [nucleotide binding]; other site
196627004404	putative Zn2+ binding site [ion binding]; other site
196627004405	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
196627004406	arsenical-resistance protein; Region: acr3; TIGR00832
196627004407	Low molecular weight phosphatase family; Region: LMWPc; cl00105
196627004408	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
196627004409	active site
196627004410	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
196627004411	Low molecular weight phosphatase family; Region: LMWPc; cl00105
196627004412	active site
196627004413	cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447
196627004414	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
196627004415	active site
196627004416	HIGH motif; other site
196627004417	nucleotide binding site [chemical binding]; other site
196627004418	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
196627004419	active site
196627004420	KMSKS motif; other site
196627004421	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
196627004422	tRNA binding surface [nucleotide binding]; other site
196627004423	anticodon binding site; other site
196627004424	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
196627004425	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
196627004426	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
196627004427	active site
196627004428	catalytic tetrad [active]
196627004429	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
196627004430	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
196627004431	quinone interaction residues [chemical binding]; other site
196627004432	active site
196627004433	catalytic residues [active]
196627004434	FMN binding site [chemical binding]; other site
196627004435	substrate binding site [chemical binding]; other site
196627004436	Integrase core domain; Region: rve; pfam00665
196627004437	DDE domain; Region: DDE_Tnp_IS240; pfam13610
196627004438	Integrase core domain; Region: rve_3; pfam13683
196627004439	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
196627004440	substrate binding site [chemical binding]; other site
196627004441	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
196627004442	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196627004443	Walker A/P-loop; other site
196627004444	ATP binding site [chemical binding]; other site
196627004445	Q-loop/lid; other site
196627004446	ABC transporter signature motif; other site
196627004447	Walker B; other site
196627004448	D-loop; other site
196627004449	H-loop/switch region; other site
196627004450	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
196627004451	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
196627004452	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196627004453	Q-loop/lid; other site
196627004454	ABC transporter signature motif; other site
196627004455	Walker B; other site
196627004456	D-loop; other site
196627004457	H-loop/switch region; other site
196627004458	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
196627004459	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
196627004460	Coenzyme A binding pocket [chemical binding]; other site
196627004461	membrane ATPase/protein kinase; Provisional; Region: PRK09435
196627004462	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
196627004463	Walker A; other site
196627004464	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
196627004465	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
196627004466	active site
196627004467	substrate binding site [chemical binding]; other site
196627004468	coenzyme B12 binding site [chemical binding]; other site
196627004469	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
196627004470	B12 binding site [chemical binding]; other site
196627004471	cobalt ligand [ion binding]; other site
196627004472	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
196627004473	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
196627004474	heterodimer interface [polypeptide binding]; other site
196627004475	substrate interaction site [chemical binding]; other site
196627004476	Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Region: Sbm; COG2185
196627004477	Uncharacterized conserved protein [Function unknown]; Region: COG0398
196627004478	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
196627004479	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
196627004480	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
196627004481	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
196627004482	Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
196627004483	ferrochelatase; Reviewed; Region: hemH; PRK00035
196627004484	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
196627004485	C-terminal domain interface [polypeptide binding]; other site
196627004486	active site
196627004487	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
196627004488	active site
196627004489	N-terminal domain interface [polypeptide binding]; other site
196627004490	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
196627004491	NlpC/P60 family; Region: NLPC_P60; pfam00877
196627004492	aconitate hydratase; Validated; Region: PRK09277
196627004493	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
196627004494	substrate binding site [chemical binding]; other site
196627004495	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
196627004496	ligand binding site [chemical binding]; other site
196627004497	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
196627004498	substrate binding site [chemical binding]; other site
196627004499	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196627004500	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196627004501	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
196627004502	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
196627004503	catalytic triad [active]
196627004504	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196627004505	NADH(P)-binding; Region: NAD_binding_10; pfam13460
196627004506	NAD(P) binding site [chemical binding]; other site
196627004507	active site
196627004508	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
196627004509	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
196627004510	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
196627004511	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
196627004512	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
196627004513	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
196627004514	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
196627004515	motif II; other site
196627004516	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
196627004517	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4762
196627004518	The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910
196627004519	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
196627004520	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
196627004521	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
196627004522	DNA binding site [nucleotide binding]
196627004523	Int/Topo IB signature motif; other site
196627004524	active site
196627004525	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
196627004526	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
196627004527	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196627004528	Walker A/P-loop; other site
196627004529	ATP binding site [chemical binding]; other site
196627004530	Q-loop/lid; other site
196627004531	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
196627004532	ABC transporter signature motif; other site
196627004533	Walker B; other site
196627004534	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
196627004535	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
196627004536	Arrestin (or S-antigen), C-terminal domain; Region: Arrestin_C; cl02844
196627004537	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
196627004538	catalytic site [active]
196627004539	BNR repeat-like domain; Region: BNR_2; pfam13088
196627004540	Asp-box motif; other site
196627004541	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
196627004542	Integrase core domain; Region: rve; pfam00665
196627004543	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
196627004544	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
196627004545	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
196627004546	trimerization site [polypeptide binding]; other site
196627004547	active site
196627004548	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
196627004549	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
196627004550	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
196627004551	catalytic residue [active]
196627004552	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
196627004553	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
196627004554	Walker A/P-loop; other site
196627004555	ATP binding site [chemical binding]; other site
196627004556	Q-loop/lid; other site
196627004557	ABC transporter signature motif; other site
196627004558	Walker B; other site
196627004559	D-loop; other site
196627004560	H-loop/switch region; other site
196627004561	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
196627004562	FeS assembly protein SufD; Region: sufD; TIGR01981
196627004563	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
196627004564	FeS assembly protein SufB; Region: sufB; TIGR01980
196627004565	Predicted transcriptional regulator [Transcription]; Region: COG2345
196627004566	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196627004567	putative DNA binding site [nucleotide binding]; other site
196627004568	putative Zn2+ binding site [ion binding]; other site
196627004569	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
196627004570	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
196627004571	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
196627004572	Walker A/P-loop; other site
196627004573	ATP binding site [chemical binding]; other site
196627004574	Q-loop/lid; other site
196627004575	ABC transporter signature motif; other site
196627004576	Walker B; other site
196627004577	D-loop; other site
196627004578	H-loop/switch region; other site
196627004579	ABC-2 type transporter; Region: ABC2_membrane; cl17235
196627004580	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
196627004581	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
196627004582	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
196627004583	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4951
196627004584	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
196627004585	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196627004586	ATP binding site [chemical binding]; other site
196627004587	putative Mg++ binding site [ion binding]; other site
196627004588	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196627004589	nucleotide binding region [chemical binding]; other site
196627004590	ATP-binding site [chemical binding]; other site
196627004591	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
196627004592	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
196627004593	NADP binding site [chemical binding]; other site
196627004594	dimer interface [polypeptide binding]; other site
196627004595	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
196627004596	UbiA prenyltransferase family; Region: UbiA; pfam01040
196627004597	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
196627004598	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
196627004599	TPP-binding site [chemical binding]; other site
196627004600	dimer interface [polypeptide binding]; other site
196627004601	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
196627004602	PYR/PP interface [polypeptide binding]; other site
196627004603	dimer interface [polypeptide binding]; other site
196627004604	TPP binding site [chemical binding]; other site
196627004605	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
196627004606	putative active site [active]
196627004607	transaldolase; Provisional; Region: PRK03903
196627004608	catalytic residue [active]
196627004609	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
196627004610	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
196627004611	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
196627004612	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
196627004613	Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429
196627004614	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
196627004615	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
196627004616	putative active site [active]
196627004617	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
196627004618	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
196627004619	FAD dependent oxidoreductase; Region: DAO; pfam01266
196627004620	hydroxyglutarate oxidase; Provisional; Region: PRK11728
196627004621	ornithine cyclodeaminase; Validated; Region: PRK06199
196627004622	Ornithine cyclodeaminase/mu-crystallin family; Region: OCD_Mu_crystall; pfam02423
196627004623	ammonium transporter; Region: amt; TIGR00836
196627004624	Preprotein translocase SecG subunit; Region: SecG; cl09123
196627004625	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
196627004626	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
196627004627	triosephosphate isomerase; Provisional; Region: PRK14567
196627004628	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
196627004629	substrate binding site [chemical binding]; other site
196627004630	dimer interface [polypeptide binding]; other site
196627004631	catalytic triad [active]
196627004632	Phosphoglycerate kinase; Region: PGK; pfam00162
196627004633	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
196627004634	substrate binding site [chemical binding]; other site
196627004635	hinge regions; other site
196627004636	ADP binding site [chemical binding]; other site
196627004637	catalytic site [active]
196627004638	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
196627004639	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
196627004640	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
196627004641	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
196627004642	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
196627004643	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
196627004644	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
196627004645	phosphate binding site [ion binding]; other site
196627004646	putative substrate binding pocket [chemical binding]; other site
196627004647	dimer interface [polypeptide binding]; other site
196627004648	Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660
196627004649	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
196627004650	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
196627004651	GIY-YIG motif/motif A; other site
196627004652	active site
196627004653	catalytic site [active]
196627004654	putative DNA binding site [nucleotide binding]; other site
196627004655	metal binding site [ion binding]; metal-binding site
196627004656	UvrB/uvrC motif; Region: UVR; pfam02151
196627004657	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
196627004658	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
196627004659	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
196627004660	homopentamer interface [polypeptide binding]; other site
196627004661	active site
196627004662	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
196627004663	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
196627004664	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
196627004665	dimerization interface [polypeptide binding]; other site
196627004666	active site
196627004667	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
196627004668	Lumazine binding domain; Region: Lum_binding; pfam00677
196627004669	Lumazine binding domain; Region: Lum_binding; pfam00677
196627004670	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
196627004671	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
196627004672	catalytic motif [active]
196627004673	Zn binding site [ion binding]; other site
196627004674	RibD C-terminal domain; Region: RibD_C; pfam01872
196627004675	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
196627004676	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
196627004677	substrate binding site [chemical binding]; other site
196627004678	hexamer interface [polypeptide binding]; other site
196627004679	metal binding site [ion binding]; metal-binding site
196627004680	16S rRNA methyltransferase B; Provisional; Region: PRK14902
196627004681	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
196627004682	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196627004683	S-adenosylmethionine binding site [chemical binding]; other site
196627004684	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
196627004685	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
196627004686	putative active site [active]
196627004687	substrate binding site [chemical binding]; other site
196627004688	putative cosubstrate binding site; other site
196627004689	catalytic site [active]
196627004690	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
196627004691	substrate binding site [chemical binding]; other site
196627004692	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
196627004693	active site
196627004694	catalytic residues [active]
196627004695	metal binding site [ion binding]; metal-binding site
196627004696	primosome assembly protein PriA; Provisional; Region: PRK14873
196627004697	S-adenosylmethionine synthetase; Validated; Region: PRK05250
196627004698	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
196627004699	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
196627004700	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
196627004701	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
196627004702	Flavoprotein; Region: Flavoprotein; pfam02441
196627004703	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
196627004704	DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758
196627004705	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
196627004706	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
196627004707	catalytic site [active]
196627004708	G-X2-G-X-G-K; other site
196627004709	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
196627004710	active site
196627004711	dimer interface [polypeptide binding]; other site
196627004712	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
196627004713	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
196627004714	ATP-grasp domain; Region: ATP-grasp_4; cl17255
196627004715	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
196627004716	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
196627004717	ATP-grasp domain; Region: ATP-grasp_4; cl17255
196627004718	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
196627004719	IMP binding site; other site
196627004720	dimer interface [polypeptide binding]; other site
196627004721	interdomain contacts; other site
196627004722	partial ornithine binding site; other site
196627004723	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
196627004724	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
196627004725	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
196627004726	catalytic site [active]
196627004727	subunit interface [polypeptide binding]; other site
196627004728	dihydroorotase; Validated; Region: pyrC; PRK09357
196627004729	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
196627004730	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
196627004731	active site
196627004732	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
196627004733	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
196627004734	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
196627004735	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
196627004736	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
196627004737	active site
196627004738	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
196627004739	putative hydrophobic ligand binding site [chemical binding]; other site
196627004740	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
196627004741	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
196627004742	putative NAD(P) binding site [chemical binding]; other site
196627004743	putative active site [active]
196627004744	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
196627004745	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
196627004746	Transcription termination factor [Transcription]; Region: NusB; COG0781
196627004747	putative RNA binding site [nucleotide binding]; other site
196627004748	elongation factor P; Validated; Region: PRK00529
196627004749	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
196627004750	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
196627004751	RNA binding site [nucleotide binding]; other site
196627004752	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
196627004753	RNA binding site [nucleotide binding]; other site
196627004754	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
196627004755	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
196627004756	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
196627004757	active site
196627004758	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
196627004759	active site
196627004760	dimer interface [polypeptide binding]; other site
196627004761	metal binding site [ion binding]; metal-binding site
196627004762	shikimate kinase; Reviewed; Region: aroK; PRK00131
196627004763	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
196627004764	ADP binding site [chemical binding]; other site
196627004765	magnesium binding site [ion binding]; other site
196627004766	putative shikimate binding site; other site
196627004767	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
196627004768	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
196627004769	Tetramer interface [polypeptide binding]; other site
196627004770	active site
196627004771	FMN-binding site [chemical binding]; other site
196627004772	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
196627004773	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
196627004774	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196627004775	dimerization interface [polypeptide binding]; other site
196627004776	putative DNA binding site [nucleotide binding]; other site
196627004777	putative Zn2+ binding site [ion binding]; other site
196627004778	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
196627004779	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
196627004780	ABC-ATPase subunit  interface; other site
196627004781	dimer interface [polypeptide binding]; other site
196627004782	putative PBP binding regions; other site
196627004783	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
196627004784	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
196627004785	putative ligand binding residues [chemical binding]; other site
196627004786	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
196627004787	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
196627004788	Walker A/P-loop; other site
196627004789	ATP binding site [chemical binding]; other site
196627004790	Q-loop/lid; other site
196627004791	ABC transporter signature motif; other site
196627004792	Walker B; other site
196627004793	D-loop; other site
196627004794	H-loop/switch region; other site
196627004795	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
196627004796	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
196627004797	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
196627004798	shikimate binding site; other site
196627004799	NAD(P) binding site [chemical binding]; other site
196627004800	YceG-like family; Region: YceG; pfam02618
196627004801	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
196627004802	dimerization interface [polypeptide binding]; other site
196627004803	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
196627004804	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
196627004805	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
196627004806	motif 1; other site
196627004807	active site
196627004808	motif 2; other site
196627004809	motif 3; other site
196627004810	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
196627004811	recombination factor protein RarA; Reviewed; Region: PRK13342
196627004812	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196627004813	Walker A motif; other site
196627004814	ATP binding site [chemical binding]; other site
196627004815	Walker B motif; other site
196627004816	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
196627004817	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
196627004818	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
196627004819	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
196627004820	dimer interface [polypeptide binding]; other site
196627004821	anticodon binding site; other site
196627004822	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
196627004823	homodimer interface [polypeptide binding]; other site
196627004824	motif 1; other site
196627004825	active site
196627004826	motif 2; other site
196627004827	GAD domain; Region: GAD; pfam02938
196627004828	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
196627004829	active site
196627004830	motif 3; other site
196627004831	Predicted metalloprotease [General function prediction only]; Region: COG2321
196627004832	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
196627004833	DEAD-like helicases superfamily; Region: DEXDc; smart00487
196627004834	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196627004835	ATP binding site [chemical binding]; other site
196627004836	putative Mg++ binding site [ion binding]; other site
196627004837	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196627004838	nucleotide binding region [chemical binding]; other site
196627004839	ATP-binding site [chemical binding]; other site
196627004840	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
196627004841	Predicted membrane protein [Function unknown]; Region: COG1511
196627004842	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
196627004843	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
196627004844	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
196627004845	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196627004846	Q-loop/lid; other site
196627004847	ABC transporter signature motif; other site
196627004848	Walker B; other site
196627004849	D-loop; other site
196627004850	H-loop/switch region; other site
196627004851	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196627004852	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196627004853	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
196627004854	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
196627004855	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
196627004856	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
196627004857	LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037
196627004858	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
196627004859	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
196627004860	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
196627004861	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
196627004862	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
196627004863	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
196627004864	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
196627004865	dimer interface [polypeptide binding]; other site
196627004866	motif 1; other site
196627004867	active site
196627004868	motif 2; other site
196627004869	motif 3; other site
196627004870	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
196627004871	anticodon binding site; other site
196627004872	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
196627004873	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
196627004874	active site
196627004875	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
196627004876	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
196627004877	Zn2+ binding site [ion binding]; other site
196627004878	Mg2+ binding site [ion binding]; other site
196627004879	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
196627004880	synthetase active site [active]
196627004881	NTP binding site [chemical binding]; other site
196627004882	metal binding site [ion binding]; metal-binding site
196627004883	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
196627004884	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
196627004885	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
196627004886	active site
196627004887	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
196627004888	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
196627004889	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
196627004890	Protein export membrane protein; Region: SecD_SecF; cl14618
196627004891	Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342
196627004892	Protein export membrane protein; Region: SecD_SecF; cl14618
196627004893	Preprotein translocase subunit; Region: YajC; pfam02699
196627004894	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
196627004895	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196627004896	Walker A motif; other site
196627004897	ATP binding site [chemical binding]; other site
196627004898	Walker B motif; other site
196627004899	arginine finger; other site
196627004900	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
196627004901	Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632
196627004902	RuvA N terminal domain; Region: RuvA_N; pfam01330
196627004903	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
196627004904	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
196627004905	active site
196627004906	putative DNA-binding cleft [nucleotide binding]; other site
196627004907	dimer interface [polypeptide binding]; other site
196627004908	hypothetical protein; Validated; Region: PRK00110
196627004909	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
196627004910	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
196627004911	active site
196627004912	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
196627004913	catalytic triad [active]
196627004914	dimer interface [polypeptide binding]; other site
196627004915	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
196627004916	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
196627004917	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
196627004918	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
196627004919	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
196627004920	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
196627004921	putative acyl-acceptor binding pocket; other site
196627004922	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
196627004923	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
196627004924	nucleotide binding site/active site [active]
196627004925	HIT family signature motif; other site
196627004926	catalytic residue [active]
196627004927	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
196627004928	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
196627004929	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
196627004930	active site
196627004931	dimer interface [polypeptide binding]; other site
196627004932	motif 1; other site
196627004933	motif 2; other site
196627004934	motif 3; other site
196627004935	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
196627004936	anticodon binding site; other site
196627004937	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
196627004938	Copper(I)-binding protein [Inorganic ion transport and    metabolism]; Region: COG2847
196627004939	Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372
196627004940	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
196627004941	nucleotide binding site [chemical binding]; other site
196627004942	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
196627004943	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
196627004944	Coenzyme A binding pocket [chemical binding]; other site
196627004945	flagellin; Validated; Region: PRK08026
196627004946	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
196627004947	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196627004948	Walker A/P-loop; other site
196627004949	ATP binding site [chemical binding]; other site
196627004950	ABC transporter signature motif; other site
196627004951	Walker B; other site
196627004952	D-loop; other site
196627004953	H-loop/switch region; other site
196627004954	Phosphotransferase enzyme family; Region: APH; pfam01636
196627004955	Flavoprotein; Region: Flavoprotein; cl08021
196627004956	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236
196627004957	Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]; Region: SUA7; COG1405
196627004958	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
196627004959	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
196627004960	multiple promoter invertase; Provisional; Region: mpi; PRK13413
196627004961	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
196627004962	catalytic residues [active]
196627004963	catalytic nucleophile [active]
196627004964	Presynaptic Site I dimer interface [polypeptide binding]; other site
196627004965	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
196627004966	Synaptic Flat tetramer interface [polypeptide binding]; other site
196627004967	Synaptic Site I dimer interface [polypeptide binding]; other site
196627004968	DNA binding site [nucleotide binding]
196627004969	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
196627004970	DNA-binding interface [nucleotide binding]; DNA binding site
196627004971	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
196627004972	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
196627004973	Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453
196627004974	active site
196627004975	catalytic residues [active]
196627004976	Transcriptional regulators [Transcription]; Region: FadR; COG2186
196627004977	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
196627004978	DNA-binding site [nucleotide binding]; DNA binding site
196627004979	FCD domain; Region: FCD; pfam07729
196627004980	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
196627004981	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
196627004982	putative transposase OrfB; Reviewed; Region: PHA02517
196627004983	HTH-like domain; Region: HTH_21; pfam13276
196627004984	Integrase core domain; Region: rve; pfam00665
196627004985	Integrase core domain; Region: rve_3; pfam13683
196627004986	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
196627004987	Transposase; Region: HTH_Tnp_1; pfam01527
196627004988	Single-stranded DNA-specific exonuclease [DNA replication, recombination, and repair]; Region: RecJ; COG0608
196627004989	DHH family; Region: DHH; pfam01368
196627004990	Phage associated DNA primase [General function prediction only]; Region: COG3378
196627004991	D5 N terminal like; Region: D5_N; smart00885
196627004992	Poxvirus D5 protein-like; Region: Pox_D5; pfam03288
196627004993	VRR-NUC domain; Region: VRR_NUC; pfam08774
196627004994	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
196627004995	putative Mg++ binding site [ion binding]; other site
196627004996	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
196627004997	Domain of unknown function (DUF4406); Region: DUF4406; pfam14359
196627004998	Lsr2; Region: Lsr2; pfam11774
196627004999	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
196627005000	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
196627005001	MoxR-like ATPases [General function prediction only]; Region: COG0714
196627005002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196627005003	Walker A motif; other site
196627005004	ATP binding site [chemical binding]; other site
196627005005	Walker B motif; other site
196627005006	arginine finger; other site
196627005007	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
196627005008	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196627005009	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
196627005010	Walker A motif; other site
196627005011	ATP binding site [chemical binding]; other site
196627005012	Walker B motif; other site
196627005013	arginine finger; other site
196627005014	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196627005015	Walker A motif; other site
196627005016	ATP binding site [chemical binding]; other site
196627005017	Walker B motif; other site
196627005018	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
196627005019	Part of AAA domain; Region: AAA_19; pfam13245
196627005020	Family description; Region: UvrD_C_2; pfam13538
196627005021	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
196627005022	NUDIX domain; Region: NUDIX; pfam00293
196627005023	nudix motif; other site
196627005024	deoxynucleoside monophosphate kinase; Provisional; Region: 1; PHA02575
196627005025	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208
196627005026	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; cl17043
196627005027	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
196627005028	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
196627005029	cofactor binding site; other site
196627005030	DNA binding site [nucleotide binding]
196627005031	substrate interaction site [chemical binding]; other site
196627005032	Putative catalytic domain of type II restriction enzyme NgoFVII and similar proteins; Region: PLDc_RE_NgoFVII; cd09177
196627005033	PLD-like domain; Region: PLDc_2; pfam13091
196627005034	putative homodimer interface [polypeptide binding]; other site
196627005035	putative active site [active]
196627005036	catalytic site [active]
196627005037	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196627005038	DEAD-like helicases superfamily; Region: DEXDc; smart00487
196627005039	ATP binding site [chemical binding]; other site
196627005040	putative Mg++ binding site [ion binding]; other site
196627005041	Z1 domain; Region: Z1; pfam10593
196627005042	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
196627005043	Domain of unknown function (DUF4379); Region: DUF4379; pfam14311
196627005044	Domain of unknown function (DUF4379); Region: DUF4379; pfam14311
196627005045	Domain of unknown function (DUF4379); Region: DUF4379; pfam14311
196627005046	Domain of unknown function (DUF4379); Region: DUF4379; pfam14311
196627005047	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196627005048	Walker A motif; other site
196627005049	ATP binding site [chemical binding]; other site
196627005050	Walker B motif; other site
196627005051	arginine finger; other site
196627005052	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196627005053	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
196627005054	Walker A motif; other site
196627005055	ATP binding site [chemical binding]; other site
196627005056	Walker B motif; other site
196627005057	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
196627005058	Protein of unknown function (DUF456); Region: DUF456; pfam04306
196627005059	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
196627005060	Hantavirus nucleocapsid protein; Region: Hanta_nucleocap; pfam00846
196627005061	GIY-YIG catalytic domain; Region: GIY-YIG; pfam01541
196627005062	GIY-YIG motif/motif A; other site
196627005063	active site
196627005064	catalytic site [active]
196627005065	metal binding site [ion binding]; metal-binding site
196627005066	Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954
196627005067	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
196627005068	Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651
196627005069	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
196627005070	non-specific DNA binding site [nucleotide binding]; other site
196627005071	salt bridge; other site
196627005072	sequence-specific DNA binding site [nucleotide binding]; other site
196627005073	chromosomal replication initiation protein; Provisional; Region: PRK12422
196627005074	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
196627005075	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
196627005076	active site
196627005077	cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776
196627005078	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
196627005079	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
196627005080	LGFP repeat; Region: LGFP; pfam08310
196627005081	LGFP repeat; Region: LGFP; pfam08310
196627005082	LGFP repeat; Region: LGFP; pfam08310
196627005083	AAA-like domain; Region: AAA_10; pfam12846
196627005084	Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550
196627005085	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
196627005086	active site
196627005087	putative interdomain interaction site [polypeptide binding]; other site
196627005088	putative metal-binding site [ion binding]; other site
196627005089	putative nucleotide binding site [chemical binding]; other site
196627005090	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
196627005091	domain I; other site
196627005092	DNA binding groove [nucleotide binding]
196627005093	phosphate binding site [ion binding]; other site
196627005094	domain II; other site
196627005095	domain III; other site
196627005096	nucleotide binding site [chemical binding]; other site
196627005097	catalytic site [active]
196627005098	domain IV; other site
196627005099	DEAD-like helicases superfamily; Region: DEXDc; smart00487
196627005100	DEAD/DEAH box helicase; Region: DEAD; pfam00270
196627005101	ATP binding site [chemical binding]; other site
196627005102	putative Mg++ binding site [ion binding]; other site
196627005103	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
196627005104	Family description; Region: UvrD_C_2; pfam13538
196627005105	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
196627005106	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
196627005107	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4815
196627005108	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
196627005109	LGFP repeat; Region: LGFP; pfam08310
196627005110	LGFP repeat; Region: LGFP; pfam08310
196627005111	LGFP repeat; Region: LGFP; pfam08310
196627005112	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
196627005113	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
196627005114	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
196627005115	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
196627005116	hypothetical protein; Provisional; Region: PRK14059
196627005117	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
196627005118	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
196627005119	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
196627005120	SelR domain; Region: SelR; pfam01641
196627005121	Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253
196627005122	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
196627005123	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
196627005124	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
196627005125	catalytic site [active]
196627005126	putative active site [active]
196627005127	putative substrate binding site [chemical binding]; other site
196627005128	HRDC domain; Region: HRDC; pfam00570
196627005129	Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154
196627005130	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
196627005131	TPP-binding site; other site
196627005132	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
196627005133	PYR/PP interface [polypeptide binding]; other site
196627005134	dimer interface [polypeptide binding]; other site
196627005135	TPP binding site [chemical binding]; other site
196627005136	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
196627005137	TRAM domain; Region: TRAM; pfam01938
196627005138	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
196627005139	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
196627005140	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
196627005141	trimer interface [polypeptide binding]; other site
196627005142	active site
196627005143	Protein of unknown function (DUF3093); Region: DUF3093; pfam11292
196627005144	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
196627005145	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
196627005146	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
196627005147	active site
196627005148	dimerization interface [polypeptide binding]; other site
196627005149	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
196627005150	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
196627005151	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
196627005152	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
196627005153	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
196627005154	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
196627005155	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196627005156	DNA binding residues [nucleotide binding]
196627005157	Predicted membrane protein [Function unknown]; Region: COG2311
196627005158	Protein of unknown function (DUF418); Region: DUF418; cl12135
196627005159	Protein of unknown function (DUF418); Region: DUF418; pfam04235
196627005160	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
196627005161	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196627005162	ATP binding site [chemical binding]; other site
196627005163	putative Mg++ binding site [ion binding]; other site
196627005164	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
196627005165	Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
196627005166	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
196627005167	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196627005168	S-adenosylmethionine binding site [chemical binding]; other site
196627005169	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
196627005170	putative active site [active]
196627005171	dimerization interface [polypeptide binding]; other site
196627005172	putative tRNAtyr binding site [nucleotide binding]; other site
196627005173	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
196627005174	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
196627005175	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
196627005176	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
196627005177	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196627005178	DNA binding residues [nucleotide binding]
196627005179	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
196627005180	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
196627005181	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
196627005182	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
196627005183	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
196627005184	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
196627005185	NAD binding site [chemical binding]; other site
196627005186	homodimer interface [polypeptide binding]; other site
196627005187	active site
196627005188	substrate binding site [chemical binding]; other site
196627005189	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
196627005190	PAC2 family; Region: PAC2; pfam09754
196627005191	DEAD-like helicases superfamily; Region: DEXDc; smart00487
196627005192	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196627005193	ATP binding site [chemical binding]; other site
196627005194	putative Mg++ binding site [ion binding]; other site
196627005195	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196627005196	nucleotide binding region [chemical binding]; other site
196627005197	ATP-binding site [chemical binding]; other site
196627005198	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
196627005199	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
196627005200	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
196627005201	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
196627005202	dimerization interface [polypeptide binding]; other site
196627005203	Predicted integral membrane protein [Function unknown]; Region: COG5473
196627005204	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
196627005205	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196627005206	ATP binding site [chemical binding]; other site
196627005207	putative Mg++ binding site [ion binding]; other site
196627005208	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196627005209	nucleotide binding region [chemical binding]; other site
196627005210	ATP-binding site [chemical binding]; other site
196627005211	Helicase associated domain (HA2); Region: HA2; pfam04408
196627005212	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
196627005213	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
196627005214	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
196627005215	ATP cone domain; Region: ATP-cone; pfam03477
196627005216	LexA repressor; Validated; Region: PRK00215
196627005217	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
196627005218	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
196627005219	Catalytic site [active]
196627005220	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
196627005221	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
196627005222	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
196627005223	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
196627005224	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
196627005225	substrate binding site [chemical binding]; other site
196627005226	ATP binding site [chemical binding]; other site
196627005227	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
196627005228	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
196627005229	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
196627005230	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
196627005231	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
196627005232	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
196627005233	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
196627005234	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
196627005235	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
196627005236	putative substrate binding site [chemical binding]; other site
196627005237	putative ATP binding site [chemical binding]; other site
196627005238	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
196627005239	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
196627005240	active site
196627005241	phosphorylation site [posttranslational modification]
196627005242	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
196627005243	active site
196627005244	P-loop; other site
196627005245	phosphorylation site [posttranslational modification]
196627005246	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
196627005247	Phosphotransferase System HPr (HPr) Family; Region: PTS_HPr_family; TIGR01003
196627005248	dimerization domain swap beta strand [polypeptide binding]; other site
196627005249	regulatory protein interface [polypeptide binding]; other site
196627005250	active site
196627005251	regulatory phosphorylation site [posttranslational modification]; other site
196627005252	Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978
196627005253	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
196627005254	GTPases [General function prediction only]; Region: HflX; COG2262
196627005255	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
196627005256	HflX GTPase family; Region: HflX; cd01878
196627005257	G1 box; other site
196627005258	GTP/Mg2+ binding site [chemical binding]; other site
196627005259	Switch I region; other site
196627005260	G2 box; other site
196627005261	G3 box; other site
196627005262	Switch II region; other site
196627005263	G4 box; other site
196627005264	G5 box; other site
196627005265	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
196627005266	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
196627005267	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
196627005268	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
196627005269	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
196627005270	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
196627005271	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
196627005272	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
196627005273	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
196627005274	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
196627005275	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
196627005276	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
196627005277	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
196627005278	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
196627005279	FeS/SAM binding site; other site
196627005280	TRAM domain; Region: TRAM; cl01282
196627005281	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
196627005282	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
196627005283	Walker A/P-loop; other site
196627005284	ATP binding site [chemical binding]; other site
196627005285	Q-loop/lid; other site
196627005286	ABC transporter signature motif; other site
196627005287	Walker B; other site
196627005288	D-loop; other site
196627005289	H-loop/switch region; other site
196627005290	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
196627005291	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
196627005292	substrate binding pocket [chemical binding]; other site
196627005293	membrane-bound complex binding site; other site
196627005294	hinge residues; other site
196627005295	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
196627005296	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196627005297	dimer interface [polypeptide binding]; other site
196627005298	conserved gate region; other site
196627005299	putative PBP binding loops; other site
196627005300	ABC-ATPase subunit interface; other site
196627005301	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
196627005302	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196627005303	dimer interface [polypeptide binding]; other site
196627005304	conserved gate region; other site
196627005305	putative PBP binding loops; other site
196627005306	ABC-ATPase subunit interface; other site
196627005307	Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137
196627005308	recombinase A; Provisional; Region: recA; PRK09354
196627005309	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
196627005310	hexamer interface [polypeptide binding]; other site
196627005311	Walker A motif; other site
196627005312	ATP binding site [chemical binding]; other site
196627005313	Walker B motif; other site
196627005314	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
196627005315	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
196627005316	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
196627005317	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
196627005318	Walker A/P-loop; other site
196627005319	ATP binding site [chemical binding]; other site
196627005320	Q-loop/lid; other site
196627005321	ABC transporter signature motif; other site
196627005322	Walker B; other site
196627005323	D-loop; other site
196627005324	H-loop/switch region; other site
196627005325	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
196627005326	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
196627005327	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
196627005328	non-specific DNA binding site [nucleotide binding]; other site
196627005329	salt bridge; other site
196627005330	sequence-specific DNA binding site [nucleotide binding]; other site
196627005331	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
196627005332	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
196627005333	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350
196627005334	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
196627005335	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
196627005336	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
196627005337	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
196627005338	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
196627005339	TIGR03085 family protein; Region: TIGR03085
196627005340	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
196627005341	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
196627005342	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
196627005343	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
196627005344	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
196627005345	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
196627005346	dimer interface [polypeptide binding]; other site
196627005347	active site
196627005348	catalytic residue [active]
196627005349	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
196627005350	dihydrodipicolinate reductase; Provisional; Region: PRK00048
196627005351	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
196627005352	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
196627005353	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
196627005354	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
196627005355	oligomer interface [polypeptide binding]; other site
196627005356	RNA binding site [nucleotide binding]; other site
196627005357	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
196627005358	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
196627005359	RNase E interface [polypeptide binding]; other site
196627005360	trimer interface [polypeptide binding]; other site
196627005361	active site
196627005362	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
196627005363	putative nucleic acid binding region [nucleotide binding]; other site
196627005364	G-X-X-G motif; other site
196627005365	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
196627005366	RNA binding site [nucleotide binding]; other site
196627005367	domain interface; other site
196627005368	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
196627005369	16S/18S rRNA binding site [nucleotide binding]; other site
196627005370	S13e-L30e interaction site [polypeptide binding]; other site
196627005371	25S rRNA binding site [nucleotide binding]; other site
196627005372	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
196627005373	active site
196627005374	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
196627005375	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
196627005376	active site
196627005377	Riboflavin kinase; Region: Flavokinase; smart00904
196627005378	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
196627005379	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
196627005380	RNA binding site [nucleotide binding]; other site
196627005381	active site
196627005382	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
196627005383	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
196627005384	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
196627005385	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
196627005386	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
196627005387	active site
196627005388	metal binding site [ion binding]; metal-binding site
196627005389	putative phosphoesterase; Region: acc_ester; TIGR03729
196627005390	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
196627005391	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
196627005392	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
196627005393	DHH family; Region: DHH; pfam01368
196627005394	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
196627005395	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
196627005396	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
196627005397	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
196627005398	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
196627005399	G1 box; other site
196627005400	putative GEF interaction site [polypeptide binding]; other site
196627005401	GTP/Mg2+ binding site [chemical binding]; other site
196627005402	Switch I region; other site
196627005403	G2 box; other site
196627005404	G3 box; other site
196627005405	Switch II region; other site
196627005406	G4 box; other site
196627005407	G5 box; other site
196627005408	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
196627005409	Translation-initiation factor 2; Region: IF-2; pfam11987
196627005410	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
196627005411	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
196627005412	putative RNA binding cleft [nucleotide binding]; other site
196627005413	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
196627005414	NusA N-terminal domain; Region: NusA_N; pfam08529
196627005415	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
196627005416	RNA binding site [nucleotide binding]; other site
196627005417	homodimer interface [polypeptide binding]; other site
196627005418	NusA-like KH domain; Region: KH_5; pfam13184
196627005419	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
196627005420	G-X-X-G motif; other site
196627005421	ribosome maturation protein RimP; Reviewed; Region: PRK00092
196627005422	Sm and related proteins; Region: Sm_like; cl00259
196627005423	Sm and related proteins; Region: Sm_like; cl00259
196627005424	heptamer interface [polypeptide binding]; other site
196627005425	Sm1 motif; other site
196627005426	hexamer interface [polypeptide binding]; other site
196627005427	RNA binding site [nucleotide binding]; other site
196627005428	Sm2 motif; other site
196627005429	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
196627005430	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
196627005431	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
196627005432	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196627005433	dimer interface [polypeptide binding]; other site
196627005434	conserved gate region; other site
196627005435	ABC-ATPase subunit interface; other site
196627005436	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
196627005437	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196627005438	dimer interface [polypeptide binding]; other site
196627005439	conserved gate region; other site
196627005440	putative PBP binding loops; other site
196627005441	ABC-ATPase subunit interface; other site
196627005442	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
196627005443	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
196627005444	Walker A/P-loop; other site
196627005445	ATP binding site [chemical binding]; other site
196627005446	Q-loop/lid; other site
196627005447	ABC transporter signature motif; other site
196627005448	Walker B; other site
196627005449	D-loop; other site
196627005450	H-loop/switch region; other site
196627005451	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
196627005452	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
196627005453	Walker A/P-loop; other site
196627005454	ATP binding site [chemical binding]; other site
196627005455	Q-loop/lid; other site
196627005456	ABC transporter signature motif; other site
196627005457	Walker B; other site
196627005458	D-loop; other site
196627005459	H-loop/switch region; other site
196627005460	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
196627005461	prolyl-tRNA synthetase; Provisional; Region: PRK09194
196627005462	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
196627005463	dimer interface [polypeptide binding]; other site
196627005464	motif 1; other site
196627005465	active site
196627005466	motif 2; other site
196627005467	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
196627005468	putative deacylase active site [active]
196627005469	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
196627005470	active site
196627005471	motif 3; other site
196627005472	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
196627005473	anticodon binding site; other site
196627005474	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3022
196627005475	Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240
196627005476	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
196627005477	metal ion-dependent adhesion site (MIDAS); other site
196627005478	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
196627005479	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196627005480	Walker A motif; other site
196627005481	ATP binding site [chemical binding]; other site
196627005482	Walker B motif; other site
196627005483	arginine finger; other site
196627005484	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
196627005485	diphthine synthase; Region: dph5; TIGR00522
196627005486	active site
196627005487	SAM binding site [chemical binding]; other site
196627005488	homodimer interface [polypeptide binding]; other site
196627005489	Uncharacterized conserved protein [Function unknown]; Region: COG0397
196627005490	hypothetical protein; Validated; Region: PRK00029
196627005491	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
196627005492	dimer interface [polypeptide binding]; other site
196627005493	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
196627005494	dimer interface [polypeptide binding]; other site
196627005495	malate:quinone oxidoreductase; Validated; Region: PRK05257
196627005496	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
196627005497	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
196627005498	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
196627005499	mycothione reductase; Region: mycothione_red; TIGR03452
196627005500	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
196627005501	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
196627005502	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
196627005503	active site
196627005504	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
196627005505	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
196627005506	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
196627005507	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
196627005508	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196627005509	active site
196627005510	phosphorylation site [posttranslational modification]
196627005511	intermolecular recognition site; other site
196627005512	dimerization interface [polypeptide binding]; other site
196627005513	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
196627005514	DNA binding residues [nucleotide binding]
196627005515	dimerization interface [polypeptide binding]; other site
196627005516	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
196627005517	Histidine kinase; Region: HisKA_3; pfam07730
196627005518	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
196627005519	Mg2+ binding site [ion binding]; other site
196627005520	G-X-G motif; other site
196627005521	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
196627005522	FtsX-like permease family; Region: FtsX; pfam02687
196627005523	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
196627005524	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
196627005525	Walker A/P-loop; other site
196627005526	ATP binding site [chemical binding]; other site
196627005527	Q-loop/lid; other site
196627005528	ABC transporter signature motif; other site
196627005529	Walker B; other site
196627005530	D-loop; other site
196627005531	H-loop/switch region; other site
196627005532	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
196627005533	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
196627005534	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
196627005535	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
196627005536	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
196627005537	active site
196627005538	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
196627005539	protein binding site [polypeptide binding]; other site
196627005540	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
196627005541	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
196627005542	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
196627005543	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
196627005544	Protein of unknown function (DUF2631); Region: DUF2631; pfam10939
196627005545	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
196627005546	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
196627005547	Walker A/P-loop; other site
196627005548	ATP binding site [chemical binding]; other site
196627005549	Q-loop/lid; other site
196627005550	ABC transporter signature motif; other site
196627005551	Walker B; other site
196627005552	D-loop; other site
196627005553	H-loop/switch region; other site
196627005554	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459
196627005555	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
196627005556	FeS/SAM binding site; other site
196627005557	Uncharacterized integral membrane protein [Function unknown]; Region: COG5416
196627005558	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
196627005559	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
196627005560	ribosome recycling factor; Reviewed; Region: frr; PRK00083
196627005561	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
196627005562	hinge region; other site
196627005563	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
196627005564	putative nucleotide binding site [chemical binding]; other site
196627005565	uridine monophosphate binding site [chemical binding]; other site
196627005566	homohexameric interface [polypeptide binding]; other site
196627005567	elongation factor Ts; Provisional; Region: tsf; PRK09377
196627005568	UBA/TS-N domain; Region: UBA; pfam00627
196627005569	Elongation factor TS; Region: EF_TS; pfam00889
196627005570	Elongation factor TS; Region: EF_TS; pfam00889
196627005571	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
196627005572	rRNA interaction site [nucleotide binding]; other site
196627005573	S8 interaction site; other site
196627005574	putative laminin-1 binding site; other site
196627005575	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
196627005576	Peptidase family M23; Region: Peptidase_M23; pfam01551
196627005577	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
196627005578	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
196627005579	active site
196627005580	DNA binding site [nucleotide binding]
196627005581	Int/Topo IB signature motif; other site
196627005582	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
196627005583	DNA protecting protein DprA; Region: dprA; TIGR00732
196627005584	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
196627005585	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
196627005586	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
196627005587	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
196627005588	hypothetical protein; Reviewed; Region: PRK12497
196627005589	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
196627005590	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
196627005591	RNA/DNA hybrid binding site [nucleotide binding]; other site
196627005592	active site
196627005593	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
196627005594	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
196627005595	Catalytic site [active]
196627005596	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
196627005597	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
196627005598	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
196627005599	siderophore binding site; other site
196627005600	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
196627005601	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
196627005602	active site
196627005603	pyrophosphate binding site [ion binding]; other site
196627005604	thiamine phosphate binding site [chemical binding]; other site
196627005605	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
196627005606	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
196627005607	thiS-thiF/thiG interaction site; other site
196627005608	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
196627005609	ThiS interaction site; other site
196627005610	putative active site [active]
196627005611	tetramer interface [polypeptide binding]; other site
196627005612	thiamine biosynthesis protein ThiF; Validated; Region: PRK05600
196627005613	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
196627005614	ATP binding site [chemical binding]; other site
196627005615	substrate interface [chemical binding]; other site
196627005616	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: PspE; COG0607
196627005617	active site residue [active]
196627005618	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
196627005619	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
196627005620	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
196627005621	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
196627005622	RNA binding site [nucleotide binding]; other site
196627005623	Transcriptional regulators [Transcription]; Region: PurR; COG1609
196627005624	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
196627005625	DNA binding site [nucleotide binding]
196627005626	domain linker motif; other site
196627005627	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
196627005628	dimerization interface [polypeptide binding]; other site
196627005629	ligand binding site [chemical binding]; other site
196627005630	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
196627005631	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
196627005632	transmembrane helices; other site
196627005633	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
196627005634	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
196627005635	tetramer interface [polypeptide binding]; other site
196627005636	active site
196627005637	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
196627005638	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
196627005639	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
196627005640	Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
196627005641	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
196627005642	RimM N-terminal domain; Region: RimM; pfam01782
196627005643	PRC-barrel domain; Region: PRC; pfam05239
196627005644	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
196627005645	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
196627005646	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
196627005647	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
196627005648	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
196627005649	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
196627005650	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196627005651	Walker A/P-loop; other site
196627005652	ATP binding site [chemical binding]; other site
196627005653	Q-loop/lid; other site
196627005654	ABC transporter signature motif; other site
196627005655	Walker B; other site
196627005656	D-loop; other site
196627005657	H-loop/switch region; other site
196627005658	signal recognition particle protein; Provisional; Region: PRK10867
196627005659	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
196627005660	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
196627005661	P loop; other site
196627005662	GTP binding site [chemical binding]; other site
196627005663	Signal peptide binding domain; Region: SRP_SPB; pfam02978
196627005664	PII uridylyl-transferase; Provisional; Region: glnD; PRK00227
196627005665	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
196627005666	metal binding triad; other site
196627005667	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
196627005668	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
196627005669	Zn2+ binding site [ion binding]; other site
196627005670	Mg2+ binding site [ion binding]; other site
196627005671	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
196627005672	Nitrogen regulatory protein P-II; Region: P-II; smart00938
196627005673	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
196627005674	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
196627005675	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
196627005676	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
196627005677	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
196627005678	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
196627005679	Walker A/P-loop; other site
196627005680	ATP binding site [chemical binding]; other site
196627005681	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470
196627005682	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
196627005683	ABC transporter signature motif; other site
196627005684	Walker B; other site
196627005685	D-loop; other site
196627005686	H-loop/switch region; other site
196627005687	acylphosphatase; Provisional; Region: PRK14422
196627005688	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
196627005689	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
196627005690	Transcriptional regulator [Transcription]; Region: LysR; COG0583
196627005691	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
196627005692	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
196627005693	dimerization interface [polypeptide binding]; other site
196627005694	hypothetical protein; Provisional; Region: PRK10621
196627005695	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
196627005696	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4815
196627005697	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
196627005698	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
196627005699	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
196627005700	DNA binding site [nucleotide binding]
196627005701	catalytic residue [active]
196627005702	H2TH interface [polypeptide binding]; other site
196627005703	putative catalytic residues [active]
196627005704	turnover-facilitating residue; other site
196627005705	intercalation triad [nucleotide binding]; other site
196627005706	8OG recognition residue [nucleotide binding]; other site
196627005707	putative reading head residues; other site
196627005708	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
196627005709	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
196627005710	ribonuclease III; Reviewed; Region: rnc; PRK00102
196627005711	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
196627005712	dimerization interface [polypeptide binding]; other site
196627005713	active site
196627005714	metal binding site [ion binding]; metal-binding site
196627005715	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
196627005716	dsRNA binding site [nucleotide binding]; other site
196627005717	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
196627005718	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
196627005719	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
196627005720	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
196627005721	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
196627005722	Walker A/P-loop; other site
196627005723	ATP binding site [chemical binding]; other site
196627005724	Q-loop/lid; other site
196627005725	ABC transporter signature motif; other site
196627005726	Walker B; other site
196627005727	D-loop; other site
196627005728	H-loop/switch region; other site
196627005729	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
196627005730	Walker A/P-loop; other site
196627005731	ATP binding site [chemical binding]; other site
196627005732	ABC transporter; Region: ABC_tran; pfam00005
196627005733	Q-loop/lid; other site
196627005734	ABC transporter signature motif; other site
196627005735	Walker B; other site
196627005736	D-loop; other site
196627005737	H-loop/switch region; other site
196627005738	glutamate dehydrogenase; Provisional; Region: PRK09414
196627005739	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
196627005740	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
196627005741	NAD(P) binding site [chemical binding]; other site
196627005742	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
196627005743	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
196627005744	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
196627005745	nucleotide binding site/active site [active]
196627005746	HIT family signature motif; other site
196627005747	catalytic residue [active]
196627005748	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
196627005749	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
196627005750	metal binding site [ion binding]; metal-binding site
196627005751	putative dimer interface [polypeptide binding]; other site
196627005752	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
196627005753	putative homodimer interface [polypeptide binding]; other site
196627005754	putative active site pocket [active]
196627005755	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
196627005756	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
196627005757	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
196627005758	putative metal binding site [ion binding]; other site
196627005759	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
196627005760	active site
196627005761	pyruvate kinase; Provisional; Region: PRK06247
196627005762	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
196627005763	domain interfaces; other site
196627005764	active site
196627005765	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
196627005766	Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Region: TrpC; COG0134
196627005767	phosphate binding site [ion binding]; other site
196627005768	Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534
196627005769	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
196627005770	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
196627005771	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
196627005772	substrate binding site [chemical binding]; other site
196627005773	glutamase interaction surface [polypeptide binding]; other site
196627005774	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
196627005775	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
196627005776	active site
196627005777	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
196627005778	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
196627005779	catalytic residues [active]
196627005780	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
196627005781	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
196627005782	putative active site [active]
196627005783	oxyanion strand; other site
196627005784	catalytic triad [active]
196627005785	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627005786	Major Facilitator Superfamily; Region: MFS_1; pfam07690
196627005787	putative substrate translocation pore; other site
196627005788	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
196627005789	putative active site pocket [active]
196627005790	4-fold oligomerization interface [polypeptide binding]; other site
196627005791	metal binding residues [ion binding]; metal-binding site
196627005792	3-fold/trimer interface [polypeptide binding]; other site
196627005793	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
196627005794	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
196627005795	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196627005796	homodimer interface [polypeptide binding]; other site
196627005797	catalytic residue [active]
196627005798	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
196627005799	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
196627005800	NAD binding site [chemical binding]; other site
196627005801	dimerization interface [polypeptide binding]; other site
196627005802	product binding site; other site
196627005803	substrate binding site [chemical binding]; other site
196627005804	zinc binding site [ion binding]; other site
196627005805	catalytic residues [active]
196627005806	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
196627005807	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
196627005808	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196627005809	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196627005810	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
196627005811	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
196627005812	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
196627005813	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
196627005814	active site
196627005815	catalytic site [active]
196627005816	Methyltransferase domain; Region: Methyltransf_23; pfam13489
196627005817	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196627005818	S-adenosylmethionine binding site [chemical binding]; other site
196627005819	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
196627005820	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
196627005821	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
196627005822	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
196627005823	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
196627005824	Transcriptional regulators [Transcription]; Region: PurR; COG1609
196627005825	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
196627005826	DNA binding site [nucleotide binding]
196627005827	domain linker motif; other site
196627005828	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
196627005829	dimerization interface [polypeptide binding]; other site
196627005830	ligand binding site [chemical binding]; other site
196627005831	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
196627005832	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
196627005833	Walker A/P-loop; other site
196627005834	ATP binding site [chemical binding]; other site
196627005835	Q-loop/lid; other site
196627005836	ABC transporter signature motif; other site
196627005837	Walker B; other site
196627005838	D-loop; other site
196627005839	H-loop/switch region; other site
196627005840	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
196627005841	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
196627005842	ABC-ATPase subunit  interface; other site
196627005843	dimer interface [polypeptide binding]; other site
196627005844	putative PBP binding regions; other site
196627005845	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
196627005846	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
196627005847	putative binding site residues; other site
196627005848	Predicted transcriptional regulators [Transcription]; Region: COG1733
196627005849	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196627005850	dimerization interface [polypeptide binding]; other site
196627005851	putative DNA binding site [nucleotide binding]; other site
196627005852	putative Zn2+ binding site [ion binding]; other site
196627005853	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
196627005854	active site
196627005855	catalytic site [active]
196627005856	substrate binding site [chemical binding]; other site
196627005857	Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280
196627005858	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
196627005859	active site
196627005860	catalytic site [active]
196627005861	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
196627005862	synthetase active site [active]
196627005863	NTP binding site [chemical binding]; other site
196627005864	metal binding site [ion binding]; metal-binding site
196627005865	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
196627005866	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
196627005867	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
196627005868	RNA binding surface [nucleotide binding]; other site
196627005869	Uncharacterized conserved protein [Function unknown]; Region: COG1739
196627005870	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
196627005871	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
196627005872	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
196627005873	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
196627005874	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
196627005875	catalytic site [active]
196627005876	active site
196627005877	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
196627005878	threonine dehydratase; Validated; Region: PRK08639
196627005879	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
196627005880	tetramer interface [polypeptide binding]; other site
196627005881	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196627005882	catalytic residue [active]
196627005883	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
196627005884	putative Ile/Val binding site [chemical binding]; other site
196627005885	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
196627005886	substrate binding site [chemical binding]; other site
196627005887	THF binding site; other site
196627005888	zinc-binding site [ion binding]; other site
196627005889	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
196627005890	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
196627005891	active site
196627005892	PHP Thumb interface [polypeptide binding]; other site
196627005893	metal binding site [ion binding]; metal-binding site
196627005894	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
196627005895	generic binding surface II; other site
196627005896	generic binding surface I; other site
196627005897	Predicted permeases [General function prediction only]; Region: RarD; COG2962
196627005898	EamA-like transporter family; Region: EamA; cl17759
196627005899	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
196627005900	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
196627005901	Cation efflux family; Region: Cation_efflux; pfam01545
196627005902	oxidoreductase; Provisional; Region: PRK06128
196627005903	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196627005904	NAD(P) binding site [chemical binding]; other site
196627005905	active site
196627005906	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
196627005907	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
196627005908	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
196627005909	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842
196627005910	dimer interface [polypeptide binding]; other site
196627005911	active site
196627005912	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
196627005913	catalytic residues [active]
196627005914	substrate binding site [chemical binding]; other site
196627005915	2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945
196627005916	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
196627005917	dimer interface [polypeptide binding]; other site
196627005918	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196627005919	catalytic residue [active]
196627005920	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
196627005921	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
196627005922	active site
196627005923	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
196627005924	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
196627005925	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196627005926	Walker A/P-loop; other site
196627005927	ATP binding site [chemical binding]; other site
196627005928	Q-loop/lid; other site
196627005929	ABC transporter signature motif; other site
196627005930	Walker B; other site
196627005931	D-loop; other site
196627005932	H-loop/switch region; other site
196627005933	ABC transporter; Region: ABC_tran_2; pfam12848
196627005934	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
196627005935	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
196627005936	active site
196627005937	homotetramer interface [polypeptide binding]; other site
196627005938	homodimer interface [polypeptide binding]; other site
196627005939	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
196627005940	Helix-turn-helix domain; Region: HTH_38; pfam13936
196627005941	Homeodomain-like domain; Region: HTH_32; pfam13565
196627005942	Integrase core domain; Region: rve; pfam00665
196627005943	DNA polymerase IV; Provisional; Region: PRK03348
196627005944	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
196627005945	active site
196627005946	DNA binding site [nucleotide binding]
196627005947	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
196627005948	Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788
196627005949	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
196627005950	DNA binding residues [nucleotide binding]
196627005951	putative dimer interface [polypeptide binding]; other site
196627005952	HEAT repeats; Region: HEAT_2; pfam13646
196627005953	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
196627005954	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
196627005955	HIGH motif; other site
196627005956	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
196627005957	active site
196627005958	KMSKS motif; other site
196627005959	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
196627005960	tRNA binding surface [nucleotide binding]; other site
196627005961	anticodon binding site; other site
196627005962	DivIVA protein; Region: DivIVA; pfam05103
196627005963	DivIVA domain; Region: DivI1A_domain; TIGR03544
196627005964	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
196627005965	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
196627005966	Predicted integral membrane protein [Function unknown]; Region: COG0762
196627005967	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
196627005968	Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325
196627005969	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
196627005970	catalytic residue [active]
196627005971	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
196627005972	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
196627005973	Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206
196627005974	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
196627005975	nucleotide binding site [chemical binding]; other site
196627005976	SulA interaction site; other site
196627005977	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
196627005978	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
196627005979	Cell division protein FtsQ; Region: FtsQ; pfam03799
196627005980	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
196627005981	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
196627005982	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
196627005983	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
196627005984	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
196627005985	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
196627005986	active site
196627005987	homodimer interface [polypeptide binding]; other site
196627005988	cell division protein FtsW; Region: ftsW; TIGR02614
196627005989	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141
196627005990	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
196627005991	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
196627005992	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
196627005993	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
196627005994	Mg++ binding site [ion binding]; other site
196627005995	putative catalytic motif [active]
196627005996	putative substrate binding site [chemical binding]; other site
196627005997	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
196627005998	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
196627005999	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
196627006000	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
196627006001	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
196627006002	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
196627006003	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
196627006004	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
196627006005	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
196627006006	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
196627006007	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
196627006008	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
196627006009	MraW methylase family; Region: Methyltransf_5; cl17771
196627006010	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
196627006011	MraZ protein; Region: MraZ; pfam02381
196627006012	MraZ protein; Region: MraZ; pfam02381
196627006013	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
196627006014	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
196627006015	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
196627006016	Coenzyme A binding pocket [chemical binding]; other site
196627006017	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
196627006018	FAD binding site [chemical binding]; other site
196627006019	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
196627006020	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
196627006021	substrate binding pocket [chemical binding]; other site
196627006022	chain length determination region; other site
196627006023	substrate-Mg2+ binding site; other site
196627006024	catalytic residues [active]
196627006025	aspartate-rich region 1; other site
196627006026	active site lid residues [active]
196627006027	aspartate-rich region 2; other site
196627006028	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
196627006029	Helix-turn-helix domain; Region: HTH_17; pfam12728
196627006030	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
196627006031	Catalytic domain of Protein Kinases; Region: PKc; cd00180
196627006032	active site
196627006033	ATP binding site [chemical binding]; other site
196627006034	substrate binding site [chemical binding]; other site
196627006035	activation loop (A-loop); other site
196627006036	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
196627006037	PASTA domain; Region: PASTA; pfam03793
196627006038	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
196627006039	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
196627006040	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
196627006041	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
196627006042	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
196627006043	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
196627006044	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
196627006045	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
196627006046	Predicted esterase [General function prediction only]; Region: COG0627
196627006047	Predicted membrane protein [Function unknown]; Region: COG4763
196627006048	Acyltransferase family; Region: Acyl_transf_3; pfam01757
196627006049	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
196627006050	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
196627006051	putative acyl-acceptor binding pocket; other site
196627006052	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
196627006053	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
196627006054	nucleotide binding site [chemical binding]; other site
196627006055	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
196627006056	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
196627006057	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
196627006058	Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488
196627006059	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
196627006060	NlpC/P60 family; Region: NLPC_P60; pfam00877
196627006061	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
196627006062	NlpC/P60 family; Region: NLPC_P60; pfam00877
196627006063	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
196627006064	heme bH binding site [chemical binding]; other site
196627006065	intrachain domain interface; other site
196627006066	heme bL binding site [chemical binding]; other site
196627006067	interchain domain interface [polypeptide binding]; other site
196627006068	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
196627006069	Qo binding site; other site
196627006070	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
196627006071	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
196627006072	iron-sulfur cluster [ion binding]; other site
196627006073	[2Fe-2S] cluster binding site [ion binding]; other site
196627006074	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
196627006075	Cytochrome c; Region: Cytochrom_C; pfam00034
196627006076	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
196627006077	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
196627006078	Subunit I/III interface [polypeptide binding]; other site
196627006079	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
196627006080	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
196627006081	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
196627006082	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
196627006083	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
196627006084	active site
196627006085	dimer interface [polypeptide binding]; other site
196627006086	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
196627006087	Ligand Binding Site [chemical binding]; other site
196627006088	Molecular Tunnel; other site
196627006089	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
196627006090	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
196627006091	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
196627006092	homotrimer interface [polypeptide binding]; other site
196627006093	Walker A motif; other site
196627006094	GTP binding site [chemical binding]; other site
196627006095	Walker B motif; other site
196627006096	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
196627006097	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
196627006098	putative dimer interface [polypeptide binding]; other site
196627006099	active site pocket [active]
196627006100	putative cataytic base [active]
196627006101	cobalamin synthase; Reviewed; Region: cobS; PRK00235
196627006102	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
196627006103	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196627006104	NAD(P) binding site [chemical binding]; other site
196627006105	active site
196627006106	Branched-chain amino acid aminotransferase; Region: DUF3665; pfam12427
196627006107	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
196627006108	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
196627006109	homodimer interface [polypeptide binding]; other site
196627006110	substrate-cofactor binding pocket; other site
196627006111	catalytic residue [active]
196627006112	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
196627006113	multifunctional aminopeptidase A; Provisional; Region: PRK00913
196627006114	interface (dimer of trimers) [polypeptide binding]; other site
196627006115	Substrate-binding/catalytic site; other site
196627006116	Zn-binding sites [ion binding]; other site
196627006117	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
196627006118	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
196627006119	E3 interaction surface; other site
196627006120	lipoyl attachment site [posttranslational modification]; other site
196627006121	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
196627006122	E3 interaction surface; other site
196627006123	lipoyl attachment site [posttranslational modification]; other site
196627006124	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
196627006125	E3 interaction surface; other site
196627006126	lipoyl attachment site [posttranslational modification]; other site
196627006127	e3 binding domain; Region: E3_binding; pfam02817
196627006128	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
196627006129	lipoate-protein ligase B; Provisional; Region: PRK14345
196627006130	lipoyl synthase; Provisional; Region: PRK05481
196627006131	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
196627006132	FeS/SAM binding site; other site
196627006133	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
196627006134	Predicted permease [General function prediction only]; Region: COG2985
196627006135	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
196627006136	TrkA-C domain; Region: TrkA_C; pfam02080
196627006137	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
196627006138	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
196627006139	Helix-turn-helix domain; Region: HTH_38; pfam13936
196627006140	Homeodomain-like domain; Region: HTH_32; pfam13565
196627006141	Integrase core domain; Region: rve; pfam00665
196627006142	RDD family; Region: RDD; pfam06271
196627006143	glutamine synthetase, type I; Region: GlnA; TIGR00653
196627006144	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
196627006145	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
196627006146	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
196627006147	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676
196627006148	nudix motif; other site
196627006149	luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571
196627006150	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
196627006151	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
196627006152	homotrimer interaction site [polypeptide binding]; other site
196627006153	putative active site [active]
196627006154	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
196627006155	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
196627006156	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196627006157	catalytic residue [active]
196627006158	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627006159	Major Facilitator Superfamily; Region: MFS_1; pfam07690
196627006160	putative substrate translocation pore; other site
196627006161	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627006162	putative substrate translocation pore; other site
196627006163	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
196627006164	heme binding pocket [chemical binding]; other site
196627006165	heme ligand [chemical binding]; other site
196627006166	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
196627006167	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
196627006168	metal binding triad; other site
196627006169	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
196627006170	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
196627006171	metal binding triad; other site
196627006172	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
196627006173	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
196627006174	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
196627006175	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
196627006176	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374
196627006177	putative active site; other site
196627006178	putative metal binding residues [ion binding]; other site
196627006179	signature motif; other site
196627006180	putative triphosphate binding site [ion binding]; other site
196627006181	CHAD domain; Region: CHAD; pfam05235
196627006182	CHAD domain; Region: CHAD; pfam05235
196627006183	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
196627006184	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
196627006185	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
196627006186	RNB domain; Region: RNB; pfam00773
196627006187	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
196627006188	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
196627006189	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
196627006190	RNA/DNA hybrid binding site [nucleotide binding]; other site
196627006191	active site
196627006192	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
196627006193	catalytic core [active]
196627006194	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
196627006195	Putative zinc ribbon domain; Region: DUF164; pfam02591
196627006196	Uncharacterized conserved protein [Function unknown]; Region: COG0327
196627006197	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
196627006198	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
196627006199	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
196627006200	Uncharacterized conserved protein [Function unknown]; Region: COG0327
196627006201	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
196627006202	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
196627006203	motif II; other site
196627006204	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
196627006205	Low molecular weight phosphatase family; Region: LMWPc; cd00115
196627006206	active site
196627006207	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
196627006208	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
196627006209	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
196627006210	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196627006211	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196627006212	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
196627006213	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
196627006214	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
196627006215	dimer interface [polypeptide binding]; other site
196627006216	TPP-binding site [chemical binding]; other site
196627006217	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
196627006218	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196627006219	Walker A/P-loop; other site
196627006220	ATP binding site [chemical binding]; other site
196627006221	Q-loop/lid; other site
196627006222	ABC transporter signature motif; other site
196627006223	Walker B; other site
196627006224	D-loop; other site
196627006225	H-loop/switch region; other site
196627006226	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
196627006227	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
196627006228	TM-ABC transporter signature motif; other site
196627006229	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
196627006230	zinc binding site [ion binding]; other site
196627006231	putative ligand binding site [chemical binding]; other site
196627006232	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
196627006233	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
196627006234	Serine hydrolase; Region: Ser_hydrolase; cl17834
196627006235	acyl carrier protein; Provisional; Region: acpP; PRK00982
196627006236	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
196627006237	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
196627006238	active site
196627006239	motif I; other site
196627006240	motif II; other site
196627006241	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
196627006242	Uncharacterized conserved protein [Function unknown]; Region: COG4850
196627006243	Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949
196627006244	Beta-lactamase; Region: Beta-lactamase; pfam00144
196627006245	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
196627006246	Domain of unknown function (DUF4274); Region: DUF4274; pfam14096
196627006247	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
196627006248	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
196627006249	putative active site [active]
196627006250	putative metal binding site [ion binding]; other site
196627006251	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
196627006252	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
196627006253	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
196627006254	DNA primase; Validated; Region: dnaG; PRK05667
196627006255	CHC2 zinc finger; Region: zf-CHC2; pfam01807
196627006256	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
196627006257	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
196627006258	active site
196627006259	metal binding site [ion binding]; metal-binding site
196627006260	interdomain interaction site; other site
196627006261	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
196627006262	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
196627006263	RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607
196627006264	active site
196627006265	barstar interaction site; other site
196627006266	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
196627006267	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
196627006268	glutaminase active site [active]
196627006269	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
196627006270	dimer interface [polypeptide binding]; other site
196627006271	active site
196627006272	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
196627006273	dimer interface [polypeptide binding]; other site
196627006274	active site
196627006275	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
196627006276	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
196627006277	Zn2+ binding site [ion binding]; other site
196627006278	Mg2+ binding site [ion binding]; other site
196627006279	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
196627006280	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
196627006281	putative active site [active]
196627006282	Repair protein; Region: Repair_PSII; pfam04536
196627006283	glycyl-tRNA synthetase; Provisional; Region: PRK04173
196627006284	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
196627006285	motif 1; other site
196627006286	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
196627006287	active site
196627006288	motif 2; other site
196627006289	motif 3; other site
196627006290	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
196627006291	anticodon binding site; other site
196627006292	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196627006293	dimerization interface [polypeptide binding]; other site
196627006294	putative DNA binding site [nucleotide binding]; other site
196627006295	putative Zn2+ binding site [ion binding]; other site
196627006296	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
196627006297	metal binding site 2 [ion binding]; metal-binding site
196627006298	putative DNA binding helix; other site
196627006299	metal binding site 1 [ion binding]; metal-binding site
196627006300	dimer interface [polypeptide binding]; other site
196627006301	structural Zn2+ binding site [ion binding]; other site
196627006302	Domain of unknown function (DUF222); Region: DUF222; pfam02720
196627006303	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
196627006304	active site
196627006305	Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044
196627006306	diiron binding motif [ion binding]; other site
196627006307	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433
196627006308	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
196627006309	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
196627006310	catalytic residue [active]
196627006311	putative FPP diphosphate  binding site; other site
196627006312	putative FPP binding hydrophobic cleft; other site
196627006313	dimer interface [polypeptide binding]; other site
196627006314	putative IPP diphosphate binding site; other site
196627006315	Recombination protein O N terminal; Region: RecO_N; pfam11967
196627006316	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
196627006317	Recombination protein O C terminal; Region: RecO_C; pfam02565
196627006318	GTPase Era; Reviewed; Region: era; PRK00089
196627006319	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
196627006320	G1 box; other site
196627006321	GTP/Mg2+ binding site [chemical binding]; other site
196627006322	Switch I region; other site
196627006323	G2 box; other site
196627006324	Switch II region; other site
196627006325	G3 box; other site
196627006326	G4 box; other site
196627006327	G5 box; other site
196627006328	KH domain; Region: KH_2; pfam07650
196627006329	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
196627006330	Domain of unknown function DUF21; Region: DUF21; pfam01595
196627006331	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
196627006332	Transporter associated domain; Region: CorC_HlyC; smart01091
196627006333	metal-binding heat shock protein; Provisional; Region: PRK00016
196627006334	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
196627006335	PhoH-like protein; Region: PhoH; pfam02562
196627006336	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
196627006337	RNA methyltransferase, RsmE family; Region: TIGR00046
196627006338	chaperone protein DnaJ; Provisional; Region: PRK14278
196627006339	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
196627006340	HSP70 interaction site [polypeptide binding]; other site
196627006341	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
196627006342	Zn binding sites [ion binding]; other site
196627006343	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
196627006344	dimer interface [polypeptide binding]; other site
196627006345	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
196627006346	coproporphyrinogen III oxidase; Validated; Region: PRK05628
196627006347	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
196627006348	FeS/SAM binding site; other site
196627006349	HemN C-terminal domain; Region: HemN_C; pfam06969
196627006350	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
196627006351	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
196627006352	acyl-activating enzyme (AAE) consensus motif; other site
196627006353	putative AMP binding site [chemical binding]; other site
196627006354	putative active site [active]
196627006355	putative CoA binding site [chemical binding]; other site
196627006356	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
196627006357	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
196627006358	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
196627006359	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
196627006360	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
196627006361	Walker A/P-loop; other site
196627006362	ATP binding site [chemical binding]; other site
196627006363	Q-loop/lid; other site
196627006364	ABC transporter signature motif; other site
196627006365	Walker B; other site
196627006366	D-loop; other site
196627006367	H-loop/switch region; other site
196627006368	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
196627006369	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
196627006370	active site
196627006371	Zn binding site [ion binding]; other site
196627006372	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
196627006373	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
196627006374	substrate binding pocket [chemical binding]; other site
196627006375	catalytic triad [active]
196627006376	trehalose synthase; Region: treS_nterm; TIGR02456
196627006377	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
196627006378	active site
196627006379	catalytic site [active]
196627006380	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
196627006381	Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
196627006382	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
196627006383	active site
196627006384	metal binding site [ion binding]; metal-binding site
196627006385	nudix motif; other site
196627006386	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
196627006387	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
196627006388	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
196627006389	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196627006390	homodimer interface [polypeptide binding]; other site
196627006391	catalytic residue [active]
196627006392	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
196627006393	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
196627006394	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
196627006395	choline/carnitine/betaine transport; Region: bcct; TIGR00842
196627006396	Predicted permeases [General function prediction only]; Region: COG0679
196627006397	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
196627006398	FAD binding domain; Region: FAD_binding_4; pfam01565
196627006399	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
196627006400	Transcriptional regulators [Transcription]; Region: GntR; COG1802
196627006401	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
196627006402	DNA-binding site [nucleotide binding]; DNA binding site
196627006403	FCD domain; Region: FCD; pfam07729
196627006404	DctM-like transporters; Region: DctM; pfam06808
196627006405	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
196627006406	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
196627006407	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
196627006408	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
196627006409	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
196627006410	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
196627006411	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196627006412	dimer interface [polypeptide binding]; other site
196627006413	conserved gate region; other site
196627006414	putative PBP binding loops; other site
196627006415	ABC-ATPase subunit interface; other site
196627006416	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
196627006417	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
196627006418	Walker A/P-loop; other site
196627006419	ATP binding site [chemical binding]; other site
196627006420	Q-loop/lid; other site
196627006421	ABC transporter signature motif; other site
196627006422	Walker B; other site
196627006423	D-loop; other site
196627006424	H-loop/switch region; other site
196627006425	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
196627006426	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
196627006427	Walker A/P-loop; other site
196627006428	ATP binding site [chemical binding]; other site
196627006429	Q-loop/lid; other site
196627006430	ABC transporter signature motif; other site
196627006431	Walker B; other site
196627006432	D-loop; other site
196627006433	H-loop/switch region; other site
196627006434	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
196627006435	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
196627006436	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
196627006437	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
196627006438	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
196627006439	substrate binding site [chemical binding]; other site
196627006440	dimer interface [polypeptide binding]; other site
196627006441	ATP binding site [chemical binding]; other site
196627006442	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
196627006443	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
196627006444	bile acid transporter; Region: bass; TIGR00841
196627006445	Sodium Bile acid symporter family; Region: SBF; pfam01758
196627006446	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
196627006447	active site
196627006448	phosphate binding residues; other site
196627006449	catalytic residues [active]
196627006450	malate synthase G; Provisional; Region: PRK02999
196627006451	active site
196627006452	isocitrate lyase; Provisional; Region: PRK15063
196627006453	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
196627006454	tetramer interface [polypeptide binding]; other site
196627006455	active site
196627006456	Mg2+/Mn2+ binding site [ion binding]; other site
196627006457	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
196627006458	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
196627006459	putative active site [active]
196627006460	putative metal binding site [ion binding]; other site
196627006461	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
196627006462	Lamin Tail Domain; Region: LTD; pfam00932
196627006463	DctM-like transporters; Region: DctM; pfam06808
196627006464	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
196627006465	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
196627006466	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
196627006467	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
196627006468	GTP-binding protein LepA; Provisional; Region: PRK05433
196627006469	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
196627006470	G1 box; other site
196627006471	putative GEF interaction site [polypeptide binding]; other site
196627006472	GTP/Mg2+ binding site [chemical binding]; other site
196627006473	Switch I region; other site
196627006474	G2 box; other site
196627006475	G3 box; other site
196627006476	Switch II region; other site
196627006477	G4 box; other site
196627006478	G5 box; other site
196627006479	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
196627006480	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
196627006481	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
196627006482	PemK-like protein; Region: PemK; pfam02452
196627006483	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
196627006484	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
196627006485	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
196627006486	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
196627006487	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
196627006488	hypothetical protein; Validated; Region: PRK05629
196627006489	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
196627006490	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
196627006491	Competence protein; Region: Competence; pfam03772
196627006492	SLBB domain; Region: SLBB; pfam10531
196627006493	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
196627006494	Helix-hairpin-helix motif; Region: HHH; pfam00633
196627006495	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307
196627006496	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
196627006497	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
196627006498	catalytic core [active]
196627006499	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
196627006500	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
196627006501	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
196627006502	active site
196627006503	(T/H)XGH motif; other site
196627006504	Cutinase; Region: Cutinase; pfam01083
196627006505	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
196627006506	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
196627006507	putative catalytic cysteine [active]
196627006508	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159
196627006509	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
196627006510	putative ligand binding site [chemical binding]; other site
196627006511	putative NAD binding site [chemical binding]; other site
196627006512	catalytic site [active]
196627006513	glutamate 5-kinase; Region: proB; TIGR01027
196627006514	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
196627006515	nucleotide binding site [chemical binding]; other site
196627006516	homotetrameric interface [polypeptide binding]; other site
196627006517	putative phosphate binding site [ion binding]; other site
196627006518	putative allosteric binding site; other site
196627006519	PUA domain; Region: PUA; pfam01472
196627006520	GTPase CgtA; Reviewed; Region: obgE; PRK12296
196627006521	GTP1/OBG; Region: GTP1_OBG; pfam01018
196627006522	Obg GTPase; Region: Obg; cd01898
196627006523	G1 box; other site
196627006524	GTP/Mg2+ binding site [chemical binding]; other site
196627006525	Switch I region; other site
196627006526	G2 box; other site
196627006527	G3 box; other site
196627006528	Switch II region; other site
196627006529	G4 box; other site
196627006530	G5 box; other site
196627006531	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
196627006532	xanthine permease; Region: pbuX; TIGR03173
196627006533	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195
196627006534	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
196627006535	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
196627006536	active site
196627006537	catalytic tetrad [active]
196627006538	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
196627006539	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
196627006540	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
196627006541	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
196627006542	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
196627006543	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
196627006544	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
196627006545	homodimer interface [polypeptide binding]; other site
196627006546	oligonucleotide binding site [chemical binding]; other site
196627006547	Pirin-related protein [General function prediction only]; Region: COG1741
196627006548	Pirin; Region: Pirin; pfam02678
196627006549	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
196627006550	Transposase; Region: DDE_Tnp_ISL3; pfam01610
196627006551	Pirin-related protein [General function prediction only]; Region: COG1741
196627006552	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
196627006553	Uncharacterized conserved protein [Function unknown]; Region: COG2128
196627006554	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
196627006555	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
196627006556	active site
196627006557	multimer interface [polypeptide binding]; other site
196627006558	Transposase; Region: Transposase_7; pfam01526
196627006559	Predicted acetyltransferase [General function prediction only]; Region: COG2388
196627006560	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
196627006561	hydrophobic ligand binding site; other site
196627006562	Protein of unknown function (DUF4233); Region: DUF4233; pfam14017
196627006563	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
196627006564	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
196627006565	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
196627006566	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
196627006567	active site
196627006568	HIGH motif; other site
196627006569	nucleotide binding site [chemical binding]; other site
196627006570	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
196627006571	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
196627006572	active site
196627006573	KMSKS motif; other site
196627006574	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
196627006575	tRNA binding surface [nucleotide binding]; other site
196627006576	anticodon binding site; other site
196627006577	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
196627006578	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
196627006579	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
196627006580	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
196627006581	Actin-like ATPase involved in cell morphogenesis [Cell division and chromosome partitioning]; Region: MreB; COG1077
196627006582	nucleotide binding site [chemical binding]; other site
196627006583	putative NEF/HSP70 interaction site [polypeptide binding]; other site
196627006584	SBD interface [polypeptide binding]; other site
196627006585	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
196627006586	malate dehydrogenase; Provisional; Region: PRK05442
196627006587	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
196627006588	NAD(P) binding site [chemical binding]; other site
196627006589	dimer interface [polypeptide binding]; other site
196627006590	malate binding site [chemical binding]; other site
196627006591	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196627006592	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196627006593	Predicted transcriptional regulators [Transcription]; Region: COG1695
196627006594	Transcriptional regulator PadR-like family; Region: PadR; cl17335
196627006595	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
196627006596	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
196627006597	iron-sulfur cluster [ion binding]; other site
196627006598	[2Fe-2S] cluster binding site [ion binding]; other site
196627006599	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
196627006600	alpha subunit interface [polypeptide binding]; other site
196627006601	active site
196627006602	substrate binding site [chemical binding]; other site
196627006603	Fe binding site [ion binding]; other site
196627006604	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
196627006605	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
196627006606	FMN-binding pocket [chemical binding]; other site
196627006607	flavin binding motif; other site
196627006608	phosphate binding motif [ion binding]; other site
196627006609	beta-alpha-beta structure motif; other site
196627006610	NAD binding pocket [chemical binding]; other site
196627006611	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
196627006612	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
196627006613	catalytic loop [active]
196627006614	iron binding site [ion binding]; other site
196627006615	benzoate transport; Region: 2A0115; TIGR00895
196627006616	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627006617	putative substrate translocation pore; other site
196627006618	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627006619	Predicted permeases [General function prediction only]; Region: COG0679
196627006620	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
196627006621	ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994
196627006622	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
196627006623	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196627006624	Walker A motif; other site
196627006625	ATP binding site [chemical binding]; other site
196627006626	Walker B motif; other site
196627006627	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
196627006628	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844
196627006629	active site
196627006630	catalytic triad [active]
196627006631	oxyanion hole [active]
196627006632	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
196627006633	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
196627006634	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
196627006635	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
196627006636	Bacterial transcriptional regulator; Region: IclR; pfam01614
196627006637	acetyl-CoA acetyltransferase; Provisional; Region: PRK06205
196627006638	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
196627006639	dimer interface [polypeptide binding]; other site
196627006640	active site
196627006641	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
196627006642	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
196627006643	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
196627006644	DNA binding residues [nucleotide binding]
196627006645	dimerization interface [polypeptide binding]; other site
196627006646	4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425
196627006647	3-carboxy-cis,cis-muconate cycloisomerase; Region: protocat_pcaB; TIGR02426
196627006648	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
196627006649	tetramer interface [polypeptide binding]; other site
196627006650	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
196627006651	protocatechuate 3,4-dioxygenase, alpha subunit; Region: protocat_alph; TIGR02423
196627006652	active site
196627006653	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
196627006654	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
196627006655	active site
196627006656	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
196627006657	active site
196627006658	Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829
196627006659	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
196627006660	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
196627006661	metal binding site [ion binding]; metal-binding site
196627006662	substrate binding pocket [chemical binding]; other site
196627006663	catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438
196627006664	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
196627006665	active site
196627006666	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
196627006667	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
196627006668	iron-sulfur cluster [ion binding]; other site
196627006669	[2Fe-2S] cluster binding site [ion binding]; other site
196627006670	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
196627006671	putative alpha subunit interface [polypeptide binding]; other site
196627006672	putative active site [active]
196627006673	putative substrate binding site [chemical binding]; other site
196627006674	Fe binding site [ion binding]; other site
196627006675	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
196627006676	inter-subunit interface; other site
196627006677	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
196627006678	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
196627006679	catalytic loop [active]
196627006680	iron binding site [ion binding]; other site
196627006681	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
196627006682	FAD binding pocket [chemical binding]; other site
196627006683	FAD binding motif [chemical binding]; other site
196627006684	phosphate binding motif [ion binding]; other site
196627006685	beta-alpha-beta structure motif; other site
196627006686	NAD binding pocket [chemical binding]; other site
196627006687	Transcriptional regulators [Transcription]; Region: FadR; COG2186
196627006688	FCD domain; Region: FCD; pfam07729
196627006689	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823
196627006690	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196627006691	NAD(P) binding site [chemical binding]; other site
196627006692	active site
196627006693	AAA ATPase domain; Region: AAA_16; pfam13191
196627006694	AAA domain; Region: AAA_22; pfam13401
196627006695	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
196627006696	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
196627006697	DNA binding residues [nucleotide binding]
196627006698	dimerization interface [polypeptide binding]; other site
196627006699	benzoate transport; Region: 2A0115; TIGR00895
196627006700	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627006701	putative substrate translocation pore; other site
196627006702	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627006703	Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135
196627006704	benzoate transporter; Region: benE; TIGR00843
196627006705	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
196627006706	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
196627006707	oligomer interface [polypeptide binding]; other site
196627006708	active site residues [active]
196627006709	Clp protease; Region: CLP_protease; pfam00574
196627006710	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
196627006711	oligomer interface [polypeptide binding]; other site
196627006712	active site residues [active]
196627006713	trigger factor; Provisional; Region: tig; PRK01490
196627006714	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
196627006715	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
196627006716	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196627006717	dimerization interface [polypeptide binding]; other site
196627006718	putative DNA binding site [nucleotide binding]; other site
196627006719	putative Zn2+ binding site [ion binding]; other site
196627006720	Beta-lactamase; Region: Beta-lactamase; pfam00144
196627006721	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
196627006722	RDD family; Region: RDD; pfam06271
196627006723	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
196627006724	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
196627006725	Predicted membrane protein [Function unknown]; Region: COG2311
196627006726	Protein of unknown function (DUF418); Region: DUF418; pfam04235
196627006727	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
196627006728	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
196627006729	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
196627006730	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
196627006731	Zn binding site [ion binding]; other site
196627006732	Uncharacterized conserved protein [Function unknown]; Region: COG4748
196627006733	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
196627006734	phytoene desaturase; Region: crtI_fam; TIGR02734
196627006735	phytoene desaturase; Region: crtI_fam; TIGR02734
196627006736	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
196627006737	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
196627006738	active site lid residues [active]
196627006739	substrate binding pocket [chemical binding]; other site
196627006740	catalytic residues [active]
196627006741	substrate-Mg2+ binding site; other site
196627006742	aspartate-rich region 1; other site
196627006743	aspartate-rich region 2; other site
196627006744	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627006745	putative substrate translocation pore; other site
196627006746	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
196627006747	CMD domain protein, Avi_7170 family; Region: CMD_Avi_7170; TIGR04029
196627006748	alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030
196627006749	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
196627006750	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
196627006751	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
196627006752	Walker A/P-loop; other site
196627006753	ATP binding site [chemical binding]; other site
196627006754	Q-loop/lid; other site
196627006755	ABC transporter signature motif; other site
196627006756	Walker B; other site
196627006757	D-loop; other site
196627006758	H-loop/switch region; other site
196627006759	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
196627006760	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
196627006761	Walker A/P-loop; other site
196627006762	ATP binding site [chemical binding]; other site
196627006763	Q-loop/lid; other site
196627006764	ABC transporter signature motif; other site
196627006765	Walker B; other site
196627006766	D-loop; other site
196627006767	H-loop/switch region; other site
196627006768	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
196627006769	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
196627006770	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196627006771	putative PBP binding loops; other site
196627006772	dimer interface [polypeptide binding]; other site
196627006773	ABC-ATPase subunit interface; other site
196627006774	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
196627006775	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196627006776	dimer interface [polypeptide binding]; other site
196627006777	conserved gate region; other site
196627006778	putative PBP binding loops; other site
196627006779	ABC-ATPase subunit interface; other site
196627006780	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
196627006781	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492
196627006782	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
196627006783	hypothetical protein; Provisional; Region: PRK06062
196627006784	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
196627006785	inhibitor-cofactor binding pocket; inhibition site
196627006786	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196627006787	catalytic residue [active]
196627006788	Domain of unknown function (DUF222); Region: DUF222; pfam02720
196627006789	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
196627006790	active site
196627006791	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
196627006792	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
196627006793	short chain dehydrogenase; Provisional; Region: PRK08219
196627006794	HetN oxidoreductase-like, classical (c) SDR; Region: HetN_like_SDR_c; cd08932
196627006795	putative NAD(P) binding site [chemical binding]; other site
196627006796	active site
196627006797	tetracycline repressor protein TetR; Provisional; Region: PRK13756
196627006798	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196627006799	cystathionine gamma-synthase; Provisional; Region: PRK07811
196627006800	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
196627006801	homodimer interface [polypeptide binding]; other site
196627006802	substrate-cofactor binding pocket; other site
196627006803	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196627006804	catalytic residue [active]
196627006805	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196627006806	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
196627006807	Walker A/P-loop; other site
196627006808	ATP binding site [chemical binding]; other site
196627006809	Q-loop/lid; other site
196627006810	ABC transporter signature motif; other site
196627006811	Walker B; other site
196627006812	D-loop; other site
196627006813	H-loop/switch region; other site
196627006814	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
196627006815	apolar tunnel; other site
196627006816	heme binding site [chemical binding]; other site
196627006817	dimerization interface [polypeptide binding]; other site
196627006818	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
196627006819	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
196627006820	Chromate transporter; Region: Chromate_transp; pfam02417
196627006821	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
196627006822	active site
196627006823	Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524
196627006824	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
196627006825	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
196627006826	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196627006827	Walker A/P-loop; other site
196627006828	ATP binding site [chemical binding]; other site
196627006829	Q-loop/lid; other site
196627006830	ABC transporter signature motif; other site
196627006831	Walker B; other site
196627006832	D-loop; other site
196627006833	H-loop/switch region; other site
196627006834	ABC transporter; Region: ABC_tran_2; pfam12848
196627006835	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
196627006836	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
196627006837	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
196627006838	dimer interface [polypeptide binding]; other site
196627006839	ssDNA binding site [nucleotide binding]; other site
196627006840	tetramer (dimer of dimers) interface [polypeptide binding]; other site
196627006841	Copper resistance protein D; Region: CopD; cl00563
196627006842	Predicted membrane protein [Function unknown]; Region: COG3336
196627006843	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
196627006844	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
196627006845	active site
196627006846	dimer interface [polypeptide binding]; other site
196627006847	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
196627006848	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196627006849	dimer interface [polypeptide binding]; other site
196627006850	conserved gate region; other site
196627006851	putative PBP binding loops; other site
196627006852	ABC-ATPase subunit interface; other site
196627006853	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196627006854	dimer interface [polypeptide binding]; other site
196627006855	conserved gate region; other site
196627006856	putative PBP binding loops; other site
196627006857	ABC-ATPase subunit interface; other site
196627006858	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
196627006859	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
196627006860	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
196627006861	Domain of unknown function (DUF4032); Region: DUF4032; pfam13224
196627006862	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
196627006863	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
196627006864	Walker A/P-loop; other site
196627006865	ATP binding site [chemical binding]; other site
196627006866	Q-loop/lid; other site
196627006867	ABC transporter signature motif; other site
196627006868	Walker B; other site
196627006869	D-loop; other site
196627006870	H-loop/switch region; other site
196627006871	polyprenol phosphate mannosyl transferase (N-terminal truncation)
196627006872	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
196627006873	active site
196627006874	catalytic residues [active]
196627006875	DNA binding site [nucleotide binding]
196627006876	Int/Topo IB signature motif; other site
196627006877	C2 domain; Region: C2; cl14603
196627006878	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
196627006879	catalytic residues [active]
196627006880	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
196627006881	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
196627006882	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
196627006883	AIR carboxylase; Region: AIRC; smart01001
196627006884	Uncharacterized conserved protein [Function unknown]; Region: COG1641
196627006885	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
196627006886	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
196627006887	classical (c) SDRs; Region: SDR_c; cd05233
196627006888	NAD(P) binding site [chemical binding]; other site
196627006889	active site
196627006890	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
196627006891	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
196627006892	catalytic site [active]
196627006893	putative active site [active]
196627006894	putative substrate binding site [chemical binding]; other site
196627006895	dimer interface [polypeptide binding]; other site
196627006896	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
196627006897	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
196627006898	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506
196627006899	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
196627006900	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
196627006901	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
196627006902	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
196627006903	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
196627006904	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
196627006905	Transposase; Region: DDE_Tnp_ISL3; pfam01610
196627006906	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
196627006907	glutaminase; Provisional; Region: PRK00971
196627006908	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
196627006909	Transcriptional regulators [Transcription]; Region: PurR; COG1609
196627006910	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
196627006911	dimerization interface [polypeptide binding]; other site
196627006912	ligand binding site [chemical binding]; other site
196627006913	Transcriptional regulators [Transcription]; Region: PurR; COG1609
196627006914	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
196627006915	glucuronate isomerase; Reviewed; Region: PRK02925
196627006916	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
196627006917	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
196627006918	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
196627006919	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
196627006920	active site
196627006921	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
196627006922	Isochorismatase family; Region: Isochorismatase; pfam00857
196627006923	catalytic triad [active]
196627006924	metal binding site [ion binding]; metal-binding site
196627006925	conserved cis-peptide bond; other site
196627006926	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
196627006927	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
196627006928	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
196627006929	catalytic triad [active]
196627006930	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196627006931	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196627006932	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
196627006933	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
196627006934	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627006935	putative substrate translocation pore; other site
196627006936	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
196627006937	Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981
196627006938	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
196627006939	phosphate binding site [ion binding]; other site
196627006940	Domain of unknown function (DUF1729); Region: DUF1729; pfam08354
196627006941	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
196627006942	active site 2 [active]
196627006943	active site 1 [active]
196627006944	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
196627006945	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
196627006946	3-oxoacyl-[acyl-carrier protein]; Region: COG4982
196627006947	ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950
196627006948	putative NAD(P) binding site [chemical binding]; other site
196627006949	active site
196627006950	"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828
196627006951	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
196627006952	active site
196627006953	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
196627006954	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
196627006955	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
196627006956	Peptidase family M23; Region: Peptidase_M23; pfam01551
196627006957	Glucitol operon activator [Transcription]; Region: GutM; COG4578
196627006958	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
196627006959	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
196627006960	active site
196627006961	dimerization interface [polypeptide binding]; other site
196627006962	ribonuclease PH; Reviewed; Region: rph; PRK00173
196627006963	Ribonuclease PH; Region: RNase_PH_bact; cd11362
196627006964	hexamer interface [polypeptide binding]; other site
196627006965	active site
196627006966	DDE domain; Region: DDE_Tnp_IS240; pfam13610
196627006967	Integrase core domain; Region: rve; pfam00665
196627006968	Predicted membrane protein [Function unknown]; Region: COG4325
196627006969	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
196627006970	DDE domain; Region: DDE_Tnp_IS240; pfam13610
196627006971	Integrase core domain; Region: rve; pfam00665
196627006972	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
196627006973	glutamate racemase; Provisional; Region: PRK00865
196627006974	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
196627006975	MarR family; Region: MarR; pfam01047
196627006976	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
196627006977	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
196627006978	putative active site pocket [active]
196627006979	cleavage site
196627006980	Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
196627006981	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
196627006982	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
196627006983	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
196627006984	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
196627006985	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
196627006986	active site
196627006987	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
196627006988	DEAD/DEAH box helicase; Region: DEAD; pfam00270
196627006989	DEAD_2; Region: DEAD_2; pfam06733
196627006990	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
196627006991	Prion/Doppel alpha-helical domain; Region: Prion; cl02493
196627006992	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
196627006993	Peptidyl-tRNA hydrolase [Translation, ribosomal structure and biogenesis]; Region: pth2; COG1990
196627006994	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
196627006995	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
196627006996	phosphoserine phosphatase SerB; Region: serB; TIGR00338
196627006997	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
196627006998	motif II; other site
196627006999	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
196627007000	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
196627007001	D-pathway; other site
196627007002	Putative ubiquinol binding site [chemical binding]; other site
196627007003	Low-spin heme (heme b) binding site [chemical binding]; other site
196627007004	Putative water exit pathway; other site
196627007005	Binuclear center (heme o3/CuB) [ion binding]; other site
196627007006	K-pathway; other site
196627007007	Putative proton exit pathway; other site
196627007008	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
196627007009	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
196627007010	dimer interface [polypeptide binding]; other site
196627007011	putative radical transfer pathway; other site
196627007012	diiron center [ion binding]; other site
196627007013	tyrosyl radical; other site
196627007014	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
196627007015	Ferritin-like domain; Region: Ferritin; pfam00210
196627007016	ferroxidase diiron center [ion binding]; other site
196627007017	Transcriptional regulators [Transcription]; Region: FadR; COG2186
196627007018	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
196627007019	DNA-binding site [nucleotide binding]; DNA binding site
196627007020	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
196627007021	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
196627007022	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
196627007023	non-specific DNA interactions [nucleotide binding]; other site
196627007024	DNA binding site [nucleotide binding]
196627007025	sequence specific DNA binding site [nucleotide binding]; other site
196627007026	putative cAMP binding site [chemical binding]; other site
196627007027	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
196627007028	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
196627007029	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
196627007030	Class I ribonucleotide reductase; Region: RNR_I; cd01679
196627007031	active site
196627007032	dimer interface [polypeptide binding]; other site
196627007033	catalytic residues [active]
196627007034	effector binding site; other site
196627007035	R2 peptide binding site; other site
196627007036	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
196627007037	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
196627007038	catalytic residues [active]
196627007039	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
196627007040	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
196627007041	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
196627007042	homodimer interface [polypeptide binding]; other site
196627007043	NAD binding pocket [chemical binding]; other site
196627007044	ATP binding pocket [chemical binding]; other site
196627007045	Mg binding site [ion binding]; other site
196627007046	active-site loop [active]
196627007047	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3001
196627007048	Phosphotransferase enzyme family; Region: APH; pfam01636
196627007049	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
196627007050	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
196627007051	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
196627007052	NADP binding site [chemical binding]; other site
196627007053	dimer interface [polypeptide binding]; other site
196627007054	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
196627007055	(2R)-phospho-3-sulfolactate synthase (PSL synthase, CoM    biosynthesis) [Coenzyme transport and metabolism]; Region: COG1809
196627007056	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
196627007057	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
196627007058	phosphoglucomutase; Validated; Region: PRK07564
196627007059	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
196627007060	active site
196627007061	substrate binding site [chemical binding]; other site
196627007062	metal binding site [ion binding]; metal-binding site
196627007063	camphor resistance protein CrcB; Provisional; Region: ccrB; PRK00134
196627007064	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
196627007065	hypothetical protein; Provisional; Region: PRK05463
196627007066	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
196627007067	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
196627007068	LGFP repeat; Region: LGFP; pfam08310
196627007069	LGFP repeat; Region: LGFP; pfam08310
196627007070	LGFP repeat; Region: LGFP; pfam08310
196627007071	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
196627007072	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
196627007073	DDE superfamily endonuclease; Region: DDE_3; pfam13358
196627007074	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
196627007075	Predicted membrane protein [General function prediction only]; Region: COG4194
196627007076	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
196627007077	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
196627007078	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
196627007079	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
196627007080	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
196627007081	FtsX-like permease family; Region: FtsX; pfam02687
196627007082	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
196627007083	FtsX-like permease family; Region: FtsX; pfam02687
196627007084	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
196627007085	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
196627007086	Walker A/P-loop; other site
196627007087	ATP binding site [chemical binding]; other site
196627007088	Q-loop/lid; other site
196627007089	ABC transporter signature motif; other site
196627007090	Walker B; other site
196627007091	D-loop; other site
196627007092	H-loop/switch region; other site
196627007093	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
196627007094	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
196627007095	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
196627007096	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
196627007097	Methyltransferase domain; Region: Methyltransf_23; pfam13489
196627007098	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196627007099	S-adenosylmethionine binding site [chemical binding]; other site
196627007100	5S_rRNA_copy_E
196627007101	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
196627007102	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
196627007103	hinge; other site
196627007104	active site
196627007105	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
196627007106	GAF domain; Region: GAF_2; pfam13185
196627007107	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
196627007108	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
196627007109	DNA binding residues [nucleotide binding]
196627007110	dimerization interface [polypeptide binding]; other site
196627007111	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
196627007112	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
196627007113	dimer interface [polypeptide binding]; other site
196627007114	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196627007115	catalytic residue [active]
196627007116	serine O-acetyltransferase; Region: cysE; TIGR01172
196627007117	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
196627007118	trimer interface [polypeptide binding]; other site
196627007119	active site
196627007120	substrate binding site [chemical binding]; other site
196627007121	CoA binding site [chemical binding]; other site
196627007122	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
196627007123	Coenzyme A binding pocket [chemical binding]; other site
196627007124	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
196627007125	CoA binding domain; Region: CoA_binding; smart00881
196627007126	CoA-ligase; Region: Ligase_CoA; pfam00549
196627007127	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
196627007128	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
196627007129	CoA-ligase; Region: Ligase_CoA; pfam00549
196627007130	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
196627007131	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
196627007132	catalytic residues [active]
196627007133	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
196627007134	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
196627007135	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
196627007136	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
196627007137	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
196627007138	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
196627007139	FMN binding site [chemical binding]; other site
196627007140	active site
196627007141	catalytic residues [active]
196627007142	substrate binding site [chemical binding]; other site
196627007143	Phosphate uptake regulator [Inorganic ion transport and metabolism]; Region: PhoU; COG0704
196627007144	PhoU domain; Region: PhoU; pfam01895
196627007145	PhoU domain; Region: PhoU; pfam01895
196627007146	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
196627007147	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
196627007148	Walker A/P-loop; other site
196627007149	ATP binding site [chemical binding]; other site
196627007150	Q-loop/lid; other site
196627007151	ABC transporter signature motif; other site
196627007152	Walker B; other site
196627007153	D-loop; other site
196627007154	H-loop/switch region; other site
196627007155	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
196627007156	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196627007157	dimer interface [polypeptide binding]; other site
196627007158	conserved gate region; other site
196627007159	putative PBP binding loops; other site
196627007160	ABC-ATPase subunit interface; other site
196627007161	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
196627007162	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196627007163	dimer interface [polypeptide binding]; other site
196627007164	conserved gate region; other site
196627007165	putative PBP binding loops; other site
196627007166	ABC-ATPase subunit interface; other site
196627007167	PBP superfamily domain; Region: PBP_like_2; cl17296
196627007168	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
196627007169	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
196627007170	Coenzyme A binding pocket [chemical binding]; other site
196627007171	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
196627007172	Coenzyme A binding pocket [chemical binding]; other site
196627007173	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
196627007174	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
196627007175	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
196627007176	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
196627007177	heme-binding site [chemical binding]; other site
196627007178	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
196627007179	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
196627007180	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196627007181	catalytic residue [active]
196627007182	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
196627007183	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
196627007184	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
196627007185	Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
196627007186	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
196627007187	Helix-turn-helix domain; Region: HTH_38; pfam13936
196627007188	Homeodomain-like domain; Region: HTH_32; pfam13565
196627007189	Integrase core domain; Region: rve; pfam00665
196627007190	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
196627007191	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
196627007192	dimerization interface [polypeptide binding]; other site
196627007193	putative ATP binding site [chemical binding]; other site
196627007194	amidophosphoribosyltransferase; Provisional; Region: PRK07847
196627007195	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
196627007196	active site
196627007197	tetramer interface [polypeptide binding]; other site
196627007198	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
196627007199	active site
196627007200	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
196627007201	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
196627007202	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
196627007203	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
196627007204	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
196627007205	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
196627007206	dimerization interface [polypeptide binding]; other site
196627007207	ATP binding site [chemical binding]; other site
196627007208	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
196627007209	dimerization interface [polypeptide binding]; other site
196627007210	ATP binding site [chemical binding]; other site
196627007211	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
196627007212	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
196627007213	putative active site [active]
196627007214	catalytic triad [active]
196627007215	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
196627007216	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
196627007217	catalytic residues [active]
196627007218	dimer interface [polypeptide binding]; other site
196627007219	Predicted extracellular nuclease [General function prediction only]; Region: COG2374
196627007220	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
196627007221	generic binding surface II; other site
196627007222	generic binding surface I; other site
196627007223	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
196627007224	putative active site [active]
196627007225	putative catalytic site [active]
196627007226	putative Mg binding site IVb [ion binding]; other site
196627007227	putative phosphate binding site [ion binding]; other site
196627007228	putative DNA binding site [nucleotide binding]; other site
196627007229	putative Mg binding site IVa [ion binding]; other site
196627007230	Predicted deacetylase [General function prediction only]; Region: COG3233
196627007231	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374
196627007232	putative active site [active]
196627007233	putative Zn binding site [ion binding]; other site
196627007234	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
196627007235	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
196627007236	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
196627007237	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
196627007238	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
196627007239	ATP binding site [chemical binding]; other site
196627007240	active site
196627007241	substrate binding site [chemical binding]; other site
196627007242	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
196627007243	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
196627007244	tetramer interface [polypeptide binding]; other site
196627007245	aspartate aminotransferase; Provisional; Region: PRK05764
196627007246	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
196627007247	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196627007248	homodimer interface [polypeptide binding]; other site
196627007249	catalytic residue [active]
196627007250	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
196627007251	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
196627007252	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
196627007253	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
196627007254	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
196627007255	nucleotide binding site/active site [active]
196627007256	HIT family signature motif; other site
196627007257	catalytic residue [active]
196627007258	Methyltransferase domain; Region: Methyltransf_31; pfam13847
196627007259	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196627007260	S-adenosylmethionine binding site [chemical binding]; other site
196627007261	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
196627007262	POT family; Region: PTR2; cl17359
196627007263	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05630
196627007264	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
196627007265	inhibitor-cofactor binding pocket; inhibition site
196627007266	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196627007267	catalytic residue [active]
196627007268	AAA domain; Region: AAA_26; pfam13500
196627007269	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
196627007270	Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109
196627007271	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
196627007272	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
196627007273	dimerization interface [polypeptide binding]; other site
196627007274	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196627007275	dimer interface [polypeptide binding]; other site
196627007276	phosphorylation site [posttranslational modification]
196627007277	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196627007278	ATP binding site [chemical binding]; other site
196627007279	Mg2+ binding site [ion binding]; other site
196627007280	G-X-G motif; other site
196627007281	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
196627007282	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196627007283	active site
196627007284	phosphorylation site [posttranslational modification]
196627007285	intermolecular recognition site; other site
196627007286	dimerization interface [polypeptide binding]; other site
196627007287	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
196627007288	DNA binding site [nucleotide binding]
196627007289	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
196627007290	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
196627007291	DNA binding residues [nucleotide binding]
196627007292	dimer interface [polypeptide binding]; other site
196627007293	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
196627007294	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
196627007295	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820
196627007296	dimer interface [polypeptide binding]; other site
196627007297	active site
196627007298	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
196627007299	substrate binding site [chemical binding]; other site
196627007300	catalytic residue [active]
196627007301	pyruvate dehydrogenase; Provisional; Region: PRK06546
196627007302	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
196627007303	PYR/PP interface [polypeptide binding]; other site
196627007304	dimer interface [polypeptide binding]; other site
196627007305	tetramer interface [polypeptide binding]; other site
196627007306	TPP binding site [chemical binding]; other site
196627007307	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
196627007308	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
196627007309	TPP-binding site [chemical binding]; other site
196627007310	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627007311	Major Facilitator Superfamily; Region: MFS_1; pfam07690
196627007312	putative substrate translocation pore; other site
196627007313	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627007314	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196627007315	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
196627007316	Ion channel regulatory protein UNC-93; Region: UNC-93; pfam05978
196627007317	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627007318	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
196627007319	active site
196627007320	catalytic residues [active]
196627007321	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
196627007322	active site
196627007323	catalytic residues [active]
196627007324	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843
196627007325	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
196627007326	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
196627007327	dimerization interface [polypeptide binding]; other site
196627007328	substrate binding pocket [chemical binding]; other site
196627007329	diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921
196627007330	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl17742
196627007331	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
196627007332	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
196627007333	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
196627007334	active site
196627007335	motif I; other site
196627007336	motif II; other site
196627007337	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
196627007338	Uncharacterized conserved protein [Function unknown]; Region: COG5646
196627007339	Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530
196627007340	non-specific DNA binding site [nucleotide binding]; other site
196627007341	salt bridge; other site
196627007342	sequence-specific DNA binding site [nucleotide binding]; other site
196627007343	Uncharacterized conserved protein [Function unknown]; Region: COG2966
196627007344	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
196627007345	Uncharacterized conserved protein [Function unknown]; Region: COG3610
196627007346	Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380
196627007347	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
196627007348	active site
196627007349	homotetramer interface [polypeptide binding]; other site
196627007350	META domain; Region: META; cl01245
196627007351	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
196627007352	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
196627007353	Transcriptional regulators [Transcription]; Region: PurR; COG1609
196627007354	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
196627007355	DNA binding site [nucleotide binding]
196627007356	domain linker motif; other site
196627007357	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279
196627007358	putative dimerization interface [polypeptide binding]; other site
196627007359	putative ligand binding site [chemical binding]; other site
196627007360	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
196627007361	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
196627007362	intersubunit interface [polypeptide binding]; other site
196627007363	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
196627007364	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196627007365	Walker A/P-loop; other site
196627007366	ATP binding site [chemical binding]; other site
196627007367	Q-loop/lid; other site
196627007368	ABC transporter signature motif; other site
196627007369	Walker B; other site
196627007370	D-loop; other site
196627007371	H-loop/switch region; other site
196627007372	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
196627007373	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
196627007374	dimer interface [polypeptide binding]; other site
196627007375	putative PBP binding regions; other site
196627007376	ABC-ATPase subunit  interface; other site
196627007377	Winged helix-turn helix; Region: HTH_29; pfam13551
196627007378	Helix-turn-helix domain; Region: HTH_28; pfam13518
196627007379	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
196627007380	Integrase core domain; Region: rve; pfam00665
196627007381	Integrase core domain; Region: rve_3; pfam13683
196627007382	hypothetical protein; Provisional; Region: PRK12839
196627007383	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
196627007384	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
196627007385	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
196627007386	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
196627007387	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
196627007388	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627007389	putative substrate translocation pore; other site
196627007390	metabolite-proton symporter; Region: 2A0106; TIGR00883
196627007391	Transcriptional regulator [Transcription]; Region: IclR; COG1414
196627007392	Bacterial transcriptional regulator; Region: IclR; pfam01614
196627007393	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
196627007394	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
196627007395	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
196627007396	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
196627007397	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
196627007398	active site
196627007399	HIGH motif; other site
196627007400	nucleotide binding site [chemical binding]; other site
196627007401	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
196627007402	KMSKS motif; other site
196627007403	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
196627007404	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
196627007405	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
196627007406	active site turn [active]
196627007407	phosphorylation site [posttranslational modification]
196627007408	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
196627007409	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
196627007410	HPr interaction site; other site
196627007411	glycerol kinase (GK) interaction site [polypeptide binding]; other site
196627007412	active site
196627007413	phosphorylation site [posttranslational modification]
196627007414	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
196627007415	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
196627007416	substrate binding [chemical binding]; other site
196627007417	active site
196627007418	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
196627007419	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
196627007420	active site
196627007421	trimer interface [polypeptide binding]; other site
196627007422	allosteric site; other site
196627007423	active site lid [active]
196627007424	hexamer (dimer of trimers) interface [polypeptide binding]; other site
196627007425	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
196627007426	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
196627007427	active site
196627007428	dimer interface [polypeptide binding]; other site
196627007429	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
196627007430	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
196627007431	inhibitor site; inhibition site
196627007432	active site
196627007433	dimer interface [polypeptide binding]; other site
196627007434	catalytic residue [active]
196627007435	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
196627007436	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
196627007437	nucleotide binding site [chemical binding]; other site
196627007438	Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
196627007439	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
196627007440	putative active site cavity [active]
196627007441	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
196627007442	catalytic site [active]
196627007443	Asp-box motif; other site
196627007444	Transcriptional regulators [Transcription]; Region: FadR; COG2186
196627007445	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
196627007446	DNA-binding site [nucleotide binding]; DNA binding site
196627007447	FCD domain; Region: FCD; pfam07729
196627007448	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
196627007449	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
196627007450	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
196627007451	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196627007452	dimer interface [polypeptide binding]; other site
196627007453	conserved gate region; other site
196627007454	putative PBP binding loops; other site
196627007455	ABC-ATPase subunit interface; other site
196627007456	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
196627007457	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196627007458	dimer interface [polypeptide binding]; other site
196627007459	conserved gate region; other site
196627007460	putative PBP binding loops; other site
196627007461	ABC-ATPase subunit interface; other site
196627007462	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
196627007463	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
196627007464	Walker A/P-loop; other site
196627007465	ATP binding site [chemical binding]; other site
196627007466	Q-loop/lid; other site
196627007467	ABC transporter signature motif; other site
196627007468	Walker B; other site
196627007469	D-loop; other site
196627007470	H-loop/switch region; other site
196627007471	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
196627007472	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
196627007473	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
196627007474	Walker A/P-loop; other site
196627007475	ATP binding site [chemical binding]; other site
196627007476	Q-loop/lid; other site
196627007477	ABC transporter signature motif; other site
196627007478	Walker B; other site
196627007479	D-loop; other site
196627007480	H-loop/switch region; other site
196627007481	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
196627007482	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
196627007483	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
196627007484	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196627007485	putative DNA binding site [nucleotide binding]; other site
196627007486	putative Zn2+ binding site [ion binding]; other site
196627007487	AsnC family; Region: AsnC_trans_reg; pfam01037
196627007488	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
196627007489	homotrimer interaction site [polypeptide binding]; other site
196627007490	zinc binding site [ion binding]; other site
196627007491	CDP-binding sites; other site
196627007492	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
196627007493	substrate binding site; other site
196627007494	dimer interface; other site
196627007495	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
196627007496	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
196627007497	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196627007498	active site
196627007499	phosphorylation site [posttranslational modification]
196627007500	intermolecular recognition site; other site
196627007501	dimerization interface [polypeptide binding]; other site
196627007502	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
196627007503	DNA binding site [nucleotide binding]
196627007504	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
196627007505	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
196627007506	dimerization interface [polypeptide binding]; other site
196627007507	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196627007508	dimer interface [polypeptide binding]; other site
196627007509	phosphorylation site [posttranslational modification]
196627007510	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196627007511	ATP binding site [chemical binding]; other site
196627007512	Mg2+ binding site [ion binding]; other site
196627007513	G-X-G motif; other site
196627007514	DNA repair protein RadA; Provisional; Region: PRK11823
196627007515	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
196627007516	Walker A motif; other site
196627007517	ATP binding site [chemical binding]; other site
196627007518	Walker B motif; other site
196627007519	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
196627007520	Predicted nucleic-acid-binding protein (contains the HHH domain) [General function prediction only]; Region: COG1623
196627007521	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
196627007522	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
196627007523	NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151
196627007524	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
196627007525	NAD(P) binding site [chemical binding]; other site
196627007526	catalytic residues [active]
196627007527	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
196627007528	active site clefts [active]
196627007529	zinc binding site [ion binding]; other site
196627007530	dimer interface [polypeptide binding]; other site
196627007531	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
196627007532	endonuclease III; Region: ENDO3c; smart00478
196627007533	minor groove reading motif; other site
196627007534	helix-hairpin-helix signature motif; other site
196627007535	substrate binding pocket [chemical binding]; other site
196627007536	active site
196627007537	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
196627007538	Mono-functional DNA-alkylating methyl methanesulfonate N-term; Region: MMS1_N; pfam10433
196627007539	Protein of unknown function (DUF4236); Region: DUF4236; pfam14020
196627007540	meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
196627007541	acetoin reductases; Region: 23BDH; TIGR02415
196627007542	NAD binding site [chemical binding]; other site
196627007543	homotetramer interface [polypeptide binding]; other site
196627007544	homodimer interface [polypeptide binding]; other site
196627007545	active site
196627007546	substrate binding site [chemical binding]; other site
196627007547	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
196627007548	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
196627007549	Clp amino terminal domain; Region: Clp_N; pfam02861
196627007550	Clp amino terminal domain; Region: Clp_N; pfam02861
196627007551	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196627007552	Walker A motif; other site
196627007553	ATP binding site [chemical binding]; other site
196627007554	Walker B motif; other site
196627007555	arginine finger; other site
196627007556	UvrB/uvrC motif; Region: UVR; pfam02151
196627007557	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196627007558	Walker A motif; other site
196627007559	ATP binding site [chemical binding]; other site
196627007560	Walker B motif; other site
196627007561	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
196627007562	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807
196627007563	IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516
196627007564	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
196627007565	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
196627007566	active site
196627007567	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
196627007568	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
196627007569	phenol 2-monooxygenase; Provisional; Region: PRK08294
196627007570	FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979
196627007571	dimer interface [polypeptide binding]; other site
196627007572	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627007573	putative substrate translocation pore; other site
196627007574	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
196627007575	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
196627007576	dimer interface [polypeptide binding]; other site
196627007577	putative anticodon binding site; other site
196627007578	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
196627007579	motif 1; other site
196627007580	dimer interface [polypeptide binding]; other site
196627007581	active site
196627007582	motif 2; other site
196627007583	motif 3; other site
196627007584	Panthothenate synthetase [Coenzyme metabolism]; Region: PanC; COG0414
196627007585	pantoate--beta-alanine ligase; Region: panC; TIGR00018
196627007586	active site
196627007587	nucleotide binding site [chemical binding]; other site
196627007588	HIGH motif; other site
196627007589	KMSKS motif; other site
196627007590	Rossmann-like domain; Region: Rossmann-like; pfam10727
196627007591	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
196627007592	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
196627007593	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
196627007594	catalytic center binding site [active]
196627007595	ATP binding site [chemical binding]; other site
196627007596	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
196627007597	homooctamer interface [polypeptide binding]; other site
196627007598	active site
196627007599	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
196627007600	dihydropteroate synthase; Region: DHPS; TIGR01496
196627007601	substrate binding pocket [chemical binding]; other site
196627007602	dimer interface [polypeptide binding]; other site
196627007603	inhibitor binding site; inhibition site
196627007604	GTP cyclohydrolase I; Provisional; Region: PLN03044
196627007605	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
196627007606	homodecamer interface [polypeptide binding]; other site
196627007607	active site
196627007608	putative catalytic site residues [active]
196627007609	zinc binding site [ion binding]; other site
196627007610	GTP-CH-I/GFRP interaction surface; other site
196627007611	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
196627007612	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196627007613	Walker A motif; other site
196627007614	ATP binding site [chemical binding]; other site
196627007615	Walker B motif; other site
196627007616	arginine finger; other site
196627007617	Peptidase family M41; Region: Peptidase_M41; pfam01434
196627007618	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
196627007619	active site
196627007620	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
196627007621	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
196627007622	Ligand Binding Site [chemical binding]; other site
196627007623	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
196627007624	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
196627007625	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
196627007626	dimer interface [polypeptide binding]; other site
196627007627	substrate binding site [chemical binding]; other site
196627007628	metal binding sites [ion binding]; metal-binding site
196627007629	Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262
196627007630	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196627007631	S-adenosylmethionine binding site [chemical binding]; other site
196627007632	Predicted membrane protein [Function unknown]; Region: COG3766
196627007633	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
196627007634	Domain of unknown function (DUF4247); Region: DUF4247; pfam14042
196627007635	Protein of unknown function DUF2617; Region: DUF2617; pfam10936
196627007636	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
196627007637	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
196627007638	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl17885
196627007639	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
196627007640	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
196627007641	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
196627007642	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
196627007643	active site residue [active]
196627007644	Transcriptional regulators [Transcription]; Region: MarR; COG1846
196627007645	MarR family; Region: MarR_2; pfam12802
196627007646	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
196627007647	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
196627007648	acyl-activating enzyme (AAE) consensus motif; other site
196627007649	AMP binding site [chemical binding]; other site
196627007650	active site
196627007651	CoA binding site [chemical binding]; other site
196627007652	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
196627007653	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
196627007654	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
196627007655	putative CoA binding site [chemical binding]; other site
196627007656	putative trimer interface [polypeptide binding]; other site
196627007657	Protein of unknown function (DUF3754); Region: DUF3754; pfam12576
196627007658	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
196627007659	putative trimer interface [polypeptide binding]; other site
196627007660	putative CoA binding site [chemical binding]; other site
196627007661	succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407
196627007662	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101
196627007663	NAD(P) binding site [chemical binding]; other site
196627007664	catalytic residues [active]
196627007665	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
196627007666	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
196627007667	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
196627007668	ring oligomerisation interface [polypeptide binding]; other site
196627007669	ATP/Mg binding site [chemical binding]; other site
196627007670	stacking interactions; other site
196627007671	hinge regions; other site
196627007672	Tubulin like; Region: Tubulin_2; pfam13809
196627007673	von Willebrand factor (vWF) type A domain; Region: VWA; smart00327
196627007674	metal ion-dependent adhesion site (MIDAS); other site
196627007675	hypothetical protein; Provisional; Region: PRK07907
196627007676	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
196627007677	active site
196627007678	metal binding site [ion binding]; metal-binding site
196627007679	dimer interface [polypeptide binding]; other site
196627007680	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
196627007681	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644
196627007682	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
196627007683	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
196627007684	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
196627007685	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946
196627007686	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665
196627007687	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
196627007688	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
196627007689	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948
196627007690	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12592
196627007691	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
196627007692	carboxylate-amine ligase; Provisional; Region: PRK13517
196627007693	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
196627007694	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
196627007695	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
196627007696	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
196627007697	active site
196627007698	catalytic residues [active]
196627007699	metal binding site [ion binding]; metal-binding site
196627007700	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
196627007701	Coenzyme A binding pocket [chemical binding]; other site
196627007702	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
196627007703	putative catalytic site [active]
196627007704	putative phosphate binding site [ion binding]; other site
196627007705	active site
196627007706	metal binding site A [ion binding]; metal-binding site
196627007707	DNA binding site [nucleotide binding]
196627007708	putative AP binding site [nucleotide binding]; other site
196627007709	putative metal binding site B [ion binding]; other site
196627007710	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
196627007711	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
196627007712	putative active site [active]
196627007713	catalytic site [active]
196627007714	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
196627007715	putative active site [active]
196627007716	catalytic site [active]
196627007717	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
196627007718	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627007719	putative substrate translocation pore; other site
196627007720	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
196627007721	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
196627007722	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
196627007723	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
196627007724	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
196627007725	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
196627007726	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
196627007727	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196627007728	Walker A/P-loop; other site
196627007729	ATP binding site [chemical binding]; other site
196627007730	Q-loop/lid; other site
196627007731	ABC transporter signature motif; other site
196627007732	Walker B; other site
196627007733	D-loop; other site
196627007734	H-loop/switch region; other site
196627007735	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
196627007736	nudix motif; other site
196627007737	CHASE3 domain; Region: CHASE3; cl05000
196627007738	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
196627007739	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
196627007740	substrate binding pocket [chemical binding]; other site
196627007741	membrane-bound complex binding site; other site
196627007742	hinge residues; other site
196627007743	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
196627007744	Catalytic domain of Protein Kinases; Region: PKc; cd00180
196627007745	active site
196627007746	ATP binding site [chemical binding]; other site
196627007747	substrate binding site [chemical binding]; other site
196627007748	activation loop (A-loop); other site
196627007749	propionate/acetate kinase; Provisional; Region: PRK12379
196627007750	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
196627007751	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
196627007752	ferredoxin-NADP+ reductase; Region: PLN02852
196627007753	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
196627007754	Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153
196627007755	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
196627007756	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196627007757	ATP-grasp domain; Region: ATP-grasp; pfam02222
196627007758	putative transposase OrfB; Reviewed; Region: PHA02517
196627007759	HTH-like domain; Region: HTH_21; pfam13276
196627007760	Integrase core domain; Region: rve; pfam00665
196627007761	Integrase core domain; Region: rve_3; pfam13683
196627007762	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
196627007763	Transposase; Region: HTH_Tnp_1; pfam01527
196627007764	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
196627007765	Histidine kinase; Region: HisKA_3; pfam07730
196627007766	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
196627007767	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
196627007768	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196627007769	active site
196627007770	phosphorylation site [posttranslational modification]
196627007771	intermolecular recognition site; other site
196627007772	dimerization interface [polypeptide binding]; other site
196627007773	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
196627007774	DNA binding residues [nucleotide binding]
196627007775	dimerization interface [polypeptide binding]; other site
196627007776	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
196627007777	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
196627007778	GDP-binding site [chemical binding]; other site
196627007779	ACT binding site; other site
196627007780	IMP binding site; other site
196627007781	cardiolipin synthetase; Reviewed; Region: PRK12452
196627007782	Predicted membrane protein [Function unknown]; Region: COG4129
196627007783	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
196627007784	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
196627007785	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
196627007786	active site
196627007787	intersubunit interface [polypeptide binding]; other site
196627007788	zinc binding site [ion binding]; other site
196627007789	Na+ binding site [ion binding]; other site
196627007790	Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833
196627007791	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
196627007792	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
196627007793	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
196627007794	active site
196627007795	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
196627007796	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
196627007797	active site residue [active]
196627007798	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
196627007799	active site residue [active]
196627007800	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
196627007801	sequence-specific DNA binding site [nucleotide binding]; other site
196627007802	salt bridge; other site
196627007803	H+ Antiporter protein; Region: 2A0121; TIGR00900
196627007804	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627007805	putative substrate translocation pore; other site
196627007806	Domain of unknown function (DUF4265); Region: DUF4265; pfam14085
196627007807	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
196627007808	Clp amino terminal domain; Region: Clp_N; pfam02861
196627007809	Clp amino terminal domain; Region: Clp_N; pfam02861
196627007810	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196627007811	Walker A motif; other site
196627007812	ATP binding site [chemical binding]; other site
196627007813	Walker B motif; other site
196627007814	arginine finger; other site
196627007815	Protein of unknown function (DUF2730); Region: DUF2730; pfam10805
196627007816	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196627007817	Walker A motif; other site
196627007818	ATP binding site [chemical binding]; other site
196627007819	Walker B motif; other site
196627007820	arginine finger; other site
196627007821	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
196627007822	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
196627007823	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196627007824	putative DNA binding site [nucleotide binding]; other site
196627007825	dimerization interface [polypeptide binding]; other site
196627007826	putative Zn2+ binding site [ion binding]; other site
196627007827	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
196627007828	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
196627007829	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
196627007830	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
196627007831	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
196627007832	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
196627007833	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
196627007834	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
196627007835	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
196627007836	homodimer interface [polypeptide binding]; other site
196627007837	substrate-cofactor binding pocket; other site
196627007838	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196627007839	catalytic residue [active]
196627007840	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
196627007841	non-specific DNA binding site [nucleotide binding]; other site
196627007842	salt bridge; other site
196627007843	sequence-specific DNA binding site [nucleotide binding]; other site
196627007844	Cupin domain; Region: Cupin_2; pfam07883
196627007845	Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120
196627007846	Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120
196627007847	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861
196627007848	Firmicute plasmid replication protein (RepL); Region: RepL; pfam05732
196627007849	Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952
196627007850	Predicted nucleotidyltransferase [General function prediction    only]; Region: COG4849
196627007851	2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543
196627007852	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
196627007853	FAD binding pocket [chemical binding]; other site
196627007854	conserved FAD binding motif [chemical binding]; other site
196627007855	phosphate binding motif [ion binding]; other site
196627007856	beta-alpha-beta structure motif; other site
196627007857	NAD binding pocket [chemical binding]; other site
196627007858	Predicted amidohydrolase [General function prediction only]; Region: COG0388
196627007859	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
196627007860	putative active site [active]
196627007861	catalytic triad [active]
196627007862	putative dimer interface [polypeptide binding]; other site
196627007863	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
196627007864	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
196627007865	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
196627007866	NAD(P) binding site [chemical binding]; other site
196627007867	catalytic residues [active]
196627007868	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
196627007869	DNA binding residues [nucleotide binding]
196627007870	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
196627007871	putative dimer interface [polypeptide binding]; other site
196627007872	chaperone protein DnaJ; Provisional; Region: PRK14279
196627007873	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
196627007874	HSP70 interaction site [polypeptide binding]; other site
196627007875	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
196627007876	Zn binding sites [ion binding]; other site
196627007877	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
196627007878	dimer interface [polypeptide binding]; other site
196627007879	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
196627007880	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
196627007881	dimer interface [polypeptide binding]; other site
196627007882	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
196627007883	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
196627007884	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
196627007885	nucleotide binding site [chemical binding]; other site
196627007886	NEF interaction site [polypeptide binding]; other site
196627007887	SBD interface [polypeptide binding]; other site
196627007888	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
196627007889	Domain of unknown function DUF20; Region: UPF0118; pfam01594
196627007890	nucleosidase; Provisional; Region: PRK05634
196627007891	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
196627007892	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924
196627007893	Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795
196627007894	Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983
196627007895	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
196627007896	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
196627007897	Walker A/P-loop; other site
196627007898	ATP binding site [chemical binding]; other site
196627007899	Q-loop/lid; other site
196627007900	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
196627007901	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
196627007902	Protein of unknown function (DUF3375); Region: DUF3375; pfam11855
196627007903	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
196627007904	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
196627007905	NAD binding site [chemical binding]; other site
196627007906	substrate binding site [chemical binding]; other site
196627007907	catalytic Zn binding site [ion binding]; other site
196627007908	tetramer interface [polypeptide binding]; other site
196627007909	structural Zn binding site [ion binding]; other site
196627007910	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
196627007911	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
196627007912	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
196627007913	putative active site [active]
196627007914	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
196627007915	active site
196627007916	sulfate adenylyltransferase, large subunit; Region: CysN; TIGR02034
196627007917	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
196627007918	CysD dimerization site [polypeptide binding]; other site
196627007919	G1 box; other site
196627007920	putative GEF interaction site [polypeptide binding]; other site
196627007921	GTP/Mg2+ binding site [chemical binding]; other site
196627007922	Switch I region; other site
196627007923	G2 box; other site
196627007924	G3 box; other site
196627007925	Switch II region; other site
196627007926	G4 box; other site
196627007927	G5 box; other site
196627007928	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
196627007929	Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G.  Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786
196627007930	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
196627007931	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
196627007932	Active Sites [active]
196627007933	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
196627007934	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
196627007935	Active Sites [active]
196627007936	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
196627007937	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
196627007938	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
196627007939	ferredoxin-NADP+ reductase; Region: PLN02852
196627007940	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
196627007941	Fic family protein [Function unknown]; Region: COG3177
196627007942	Fic/DOC family; Region: Fic; pfam02661
196627007943	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
196627007944	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
196627007945	dimer interface [polypeptide binding]; other site
196627007946	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
196627007947	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
196627007948	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
196627007949	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
196627007950	Predicted ATPase [General function prediction only]; Region: COG3910
196627007951	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
196627007952	Walker A/P-loop; other site
196627007953	ATP binding site [chemical binding]; other site
196627007954	Q-loop/lid; other site
196627007955	ABC transporter signature motif; other site
196627007956	Walker B; other site
196627007957	D-loop; other site
196627007958	H-loop/switch region; other site
196627007959	Predicted ATPase [General function prediction only]; Region: COG3910
196627007960	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
196627007961	Walker A/P-loop; other site
196627007962	ATP binding site [chemical binding]; other site
196627007963	Q-loop/lid; other site
196627007964	ABC transporter signature motif; other site
196627007965	Walker B; other site
196627007966	D-loop; other site
196627007967	H-loop/switch region; other site
196627007968	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627007969	Major Facilitator Superfamily; Region: MFS_1; pfam07690
196627007970	putative substrate translocation pore; other site
196627007971	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
196627007972	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
196627007973	putative metal binding site [ion binding]; other site
196627007974	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
196627007975	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196627007976	Walker A/P-loop; other site
196627007977	ATP binding site [chemical binding]; other site
196627007978	Q-loop/lid; other site
196627007979	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
196627007980	ABC transporter signature motif; other site
196627007981	Walker B; other site
196627007982	D-loop; other site
196627007983	H-loop/switch region; other site
196627007984	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
196627007985	Walker A/P-loop; other site
196627007986	ATP binding site [chemical binding]; other site
196627007987	ABC transporter signature motif; other site
196627007988	Walker B; other site
196627007989	D-loop; other site
196627007990	H-loop/switch region; other site
196627007991	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
196627007992	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
196627007993	dimer interface [polypeptide binding]; other site
196627007994	FMN binding site [chemical binding]; other site
196627007995	NADPH bind site [chemical binding]; other site
196627007996	Inosine-uridine nucleoside N-ribohydrolase [Nucleotide transport and metabolism]; Region: URH1; COG1957
196627007997	active site
196627007998	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
196627007999	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
196627008000	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
196627008001	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
196627008002	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
196627008003	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
196627008004	heme-binding site [chemical binding]; other site
196627008005	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
196627008006	FAD binding pocket [chemical binding]; other site
196627008007	FAD binding motif [chemical binding]; other site
196627008008	phosphate binding motif [ion binding]; other site
196627008009	beta-alpha-beta structure motif; other site
196627008010	NAD binding pocket [chemical binding]; other site
196627008011	Heme binding  pocket [chemical binding]; other site
196627008012	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
196627008013	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
196627008014	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
196627008015	PRD domain; Region: PRD; pfam00874
196627008016	PRD domain; Region: PRD; pfam00874
196627008017	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
196627008018	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
196627008019	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
196627008020	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196627008021	H-loop/switch region; other site
196627008022	aminotransferase AlaT; Validated; Region: PRK09265
196627008023	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
196627008024	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196627008025	homodimer interface [polypeptide binding]; other site
196627008026	catalytic residue [active]
196627008027	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
196627008028	Helix-turn-helix domain; Region: HTH_38; pfam13936
196627008029	Homeodomain-like domain; Region: HTH_32; pfam13565
196627008030	Integrase core domain; Region: rve; pfam00665
196627008031	Predicted multitransmembrane protein [Function unknown]; Region: COG5438
196627008032	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
196627008033	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
196627008034	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
196627008035	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
196627008036	trimer interface [polypeptide binding]; other site
196627008037	active site
196627008038	Htaa; Region: HtaA; pfam04213
196627008039	Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720
196627008040	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
196627008041	VanW like protein; Region: VanW; pfam04294
196627008042	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
196627008043	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
196627008044	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
196627008045	Ligand Binding Site [chemical binding]; other site
196627008046	Protein of unknown function (DUF2613); Region: DUF2613; pfam11021
196627008047	Domain of unknown function (DUF3367); Region: DUF3367; pfam11847
196627008048	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
196627008049	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
196627008050	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
196627008051	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
196627008052	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196627008053	S-adenosylmethionine binding site [chemical binding]; other site
196627008054	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
196627008055	active site
196627008056	substrate-binding site [chemical binding]; other site
196627008057	metal-binding site [ion binding]
196627008058	GTP binding site [chemical binding]; other site
196627008059	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
196627008060	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320
196627008061	gating phenylalanine in ion channel; other site
196627008062	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196627008063	S-adenosylmethionine binding site [chemical binding]; other site
196627008064	LabA_like proteins; Region: LabA_like; cd06167
196627008065	putative metal binding site [ion binding]; other site
196627008066	MMPL family; Region: MMPL; pfam03176
196627008067	MMPL family; Region: MMPL; pfam03176
196627008068	Predicted integral membrane protein [Function unknown]; Region: COG0392
196627008069	Protein of unknown function (DUF3054); Region: DUF3054; pfam11255
196627008070	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
196627008071	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
196627008072	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
196627008073	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
196627008074	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
196627008075	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
196627008076	active site
196627008077	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
196627008078	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
196627008079	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
196627008080	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769
196627008081	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
196627008082	acyl-activating enzyme (AAE) consensus motif; other site
196627008083	active site
196627008084	Cutinase; Region: Cutinase; pfam01083
196627008085	Putative esterase; Region: Esterase; pfam00756
196627008086	S-formylglutathione hydrolase; Region: PLN02442
196627008087	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
196627008088	LGFP repeat; Region: LGFP; pfam08310
196627008089	LGFP repeat; Region: LGFP; pfam08310
196627008090	LGFP repeat; Region: LGFP; pfam08310
196627008091	Domain of unknown function (DUF222); Region: DUF222; pfam02720
196627008092	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
196627008093	active site
196627008094	Putative esterase; Region: Esterase; pfam00756
196627008095	S-formylglutathione hydrolase; Region: PLN02442
196627008096	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
196627008097	UbiA prenyltransferase family; Region: UbiA; pfam01040
196627008098	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
196627008099	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
196627008100	active site
196627008101	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
196627008102	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
196627008103	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
196627008104	active site
196627008105	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
196627008106	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
196627008107	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
196627008108	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
196627008109	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
196627008110	UDP-galactopyranose mutase; Region: GLF; pfam03275
196627008111	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
196627008112	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
196627008113	amidase catalytic site [active]
196627008114	Zn binding residues [ion binding]; other site
196627008115	substrate binding site [chemical binding]; other site
196627008116	LGFP repeat; Region: LGFP; pfam08310
196627008117	glycerol kinase; Provisional; Region: glpK; PRK00047
196627008118	Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789
196627008119	N- and C-terminal domain interface [polypeptide binding]; other site
196627008120	active site
196627008121	MgATP binding site [chemical binding]; other site
196627008122	catalytic site [active]
196627008123	metal binding site [ion binding]; metal-binding site
196627008124	putative homotetramer interface [polypeptide binding]; other site
196627008125	glycerol binding site [chemical binding]; other site
196627008126	homodimer interface [polypeptide binding]; other site
196627008127	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
196627008128	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
196627008129	active site
196627008130	motif I; other site
196627008131	motif II; other site
196627008132	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
196627008133	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
196627008134	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
196627008135	putative acyl-acceptor binding pocket; other site
196627008136	seryl-tRNA synthetase; Provisional; Region: PRK05431
196627008137	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
196627008138	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
196627008139	dimer interface [polypeptide binding]; other site
196627008140	active site
196627008141	motif 1; other site
196627008142	motif 2; other site
196627008143	motif 3; other site
196627008144	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
196627008145	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
196627008146	DNA-binding site [nucleotide binding]; DNA binding site
196627008147	UTRA domain; Region: UTRA; pfam07702
196627008148	Septum formation; Region: Septum_form; pfam13845
196627008149	Septum formation; Region: Septum_form; pfam13845
196627008150	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
196627008151	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
196627008152	catalytic core [active]
196627008153	prephenate dehydratase; Provisional; Region: PRK11898
196627008154	Prephenate dehydratase; Region: PDT; pfam00800
196627008155	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
196627008156	putative L-Phe binding site [chemical binding]; other site
196627008157	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
196627008158	Amidase; Region: Amidase; cl11426
196627008159	CAAX protease self-immunity; Region: Abi; pfam02517
196627008160	Transcriptional regulator [Transcription]; Region: LytR; COG1316
196627008161	Protein of unknown function (DUF3500); Region: DUF3500; pfam12006
196627008162	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
196627008163	Protein of unknown function (DUF3500); Region: DUF3500; pfam12006
196627008164	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
196627008165	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582
196627008166	putative active site [active]
196627008167	catalytic site [active]
196627008168	putative metal binding site [ion binding]; other site
196627008169	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
196627008170	fructuronate transporter; Provisional; Region: PRK10034; cl15264
196627008171	pyruvate kinase; Provisional; Region: PRK14725
196627008172	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
196627008173	active site
196627008174	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
196627008175	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
196627008176	tetramer (dimer of dimers) interface [polypeptide binding]; other site
196627008177	NAD binding site [chemical binding]; other site
196627008178	dimer interface [polypeptide binding]; other site
196627008179	substrate binding site [chemical binding]; other site
196627008180	Predicted membrane protein [Function unknown]; Region: COG4425
196627008181	Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081
196627008182	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
196627008183	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
196627008184	motif II; other site
196627008185	Predicted flavoprotein [General function prediction only]; Region: COG0431
196627008186	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
196627008187	Transcriptional regulators [Transcription]; Region: FadR; COG2186
196627008188	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
196627008189	DNA-binding site [nucleotide binding]; DNA binding site
196627008190	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
196627008191	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
196627008192	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
196627008193	active site
196627008194	metal binding site [ion binding]; metal-binding site
196627008195	metabolite-proton symporter; Region: 2A0106; TIGR00883
196627008196	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627008197	putative substrate translocation pore; other site
196627008198	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
196627008199	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
196627008200	active site
196627008201	substrate binding site [chemical binding]; other site
196627008202	FMN binding site [chemical binding]; other site
196627008203	putative catalytic residues [active]
196627008204	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
196627008205	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
196627008206	non-specific DNA binding site [nucleotide binding]; other site
196627008207	salt bridge; other site
196627008208	sequence-specific DNA binding site [nucleotide binding]; other site
196627008209	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
196627008210	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
196627008211	Uncharacterized conserved protein [Function unknown]; Region: COG4894
196627008212	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
196627008213	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
196627008214	metal binding site [ion binding]; metal-binding site
196627008215	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
196627008216	methionine sulfoxide reductase A; Provisional; Region: PRK00058
196627008217	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
196627008218	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
196627008219	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
196627008220	Transcriptional regulator [Transcription]; Region: LysR; COG0583
196627008221	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
196627008222	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
196627008223	putative dimerization interface [polypeptide binding]; other site
196627008224	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627008225	putative substrate translocation pore; other site
196627008226	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
196627008227	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
196627008228	Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251
196627008229	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
196627008230	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627008231	Major Facilitator Superfamily; Region: MFS_1; pfam07690
196627008232	putative substrate translocation pore; other site
196627008233	Transcriptional regulators [Transcription]; Region: MarR; COG1846
196627008234	MarR family; Region: MarR_2; pfam12802
196627008235	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
196627008236	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196627008237	active site
196627008238	phosphorylation site [posttranslational modification]
196627008239	intermolecular recognition site; other site
196627008240	dimerization interface [polypeptide binding]; other site
196627008241	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
196627008242	DNA binding residues [nucleotide binding]
196627008243	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
196627008244	Histidine kinase; Region: HisKA_3; pfam07730
196627008245	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196627008246	ATP binding site [chemical binding]; other site
196627008247	Mg2+ binding site [ion binding]; other site
196627008248	G-X-G motif; other site
196627008249	Domain of unknown function (DUF2020); Region: DUF2020; pfam09449
196627008250	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830
196627008251	active site
196627008252	catalytic site [active]
196627008253	putative inner membrane protein translocase component YidC; Validated; Region: PRK00247
196627008254	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
196627008255	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196627008256	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196627008257	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
196627008258	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
196627008259	Ligand Binding Site [chemical binding]; other site
196627008260	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
196627008261	Ligand Binding Site [chemical binding]; other site
196627008262	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
196627008263	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
196627008264	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
196627008265	Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558
196627008266	probable active site [active]
196627008267	Predicted transcriptional regulators [Transcription]; Region: COG1725
196627008268	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
196627008269	DNA-binding site [nucleotide binding]; DNA binding site
196627008270	LabA_like proteins; Region: LabA_like; cd06167
196627008271	putative metal binding site [ion binding]; other site
196627008272	Uncharacterized conserved protein [Function unknown]; Region: COG1432
196627008273	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
196627008274	Integrase core domain; Region: rve; pfam00665
196627008275	Integrase core domain; Region: rve_3; pfam13683
196627008276	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
196627008277	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
196627008278	metal coordination site [ion binding]; other site
196627008279	Homeodomain-like domain; Region: HTH_23; cl17451
196627008280	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
196627008281	Methyltransferase domain; Region: Methyltransf_23; pfam13489
196627008282	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196627008283	S-adenosylmethionine binding site [chemical binding]; other site
196627008284	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
196627008285	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
196627008286	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
196627008287	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
196627008288	Ferredoxin [Energy production and conversion]; Region: COG1146
196627008289	4Fe-4S binding domain; Region: Fer4; pfam00037
196627008290	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
196627008291	primosome assembly protein PriA; Validated; Region: PRK05580
196627008292	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
196627008293	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544
196627008294	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
196627008295	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
196627008296	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
196627008297	motif I; other site
196627008298	motif II; other site
196627008299	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
196627008300	metal-binding site [ion binding]
196627008301	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
196627008302	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
196627008303	dimerization interface [polypeptide binding]; other site
196627008304	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196627008305	dimer interface [polypeptide binding]; other site
196627008306	phosphorylation site [posttranslational modification]
196627008307	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196627008308	ATP binding site [chemical binding]; other site
196627008309	Mg2+ binding site [ion binding]; other site
196627008310	G-X-G motif; other site
196627008311	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
196627008312	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196627008313	active site
196627008314	phosphorylation site [posttranslational modification]
196627008315	intermolecular recognition site; other site
196627008316	dimerization interface [polypeptide binding]; other site
196627008317	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
196627008318	DNA binding site [nucleotide binding]
196627008319	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
196627008320	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
196627008321	Multicopper oxidase; Region: Cu-oxidase; pfam00394
196627008322	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
196627008323	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
196627008324	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
196627008325	catalytic residues [active]
196627008326	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
196627008327	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
196627008328	putative NAD(P) binding site [chemical binding]; other site
196627008329	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
196627008330	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
196627008331	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
196627008332	metal-binding site [ion binding]
196627008333	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
196627008334	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
196627008335	Soluble P-type ATPase [General function prediction only]; Region: COG4087
196627008336	DDE domain; Region: DDE_Tnp_IS240; pfam13610
196627008337	DDE domain; Region: DDE_Tnp_IS240; pfam13610
196627008338	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
196627008339	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
196627008340	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
196627008341	catalytic residues [active]
196627008342	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
196627008343	metal-binding site [ion binding]
196627008344	benzoate transport; Region: 2A0115; TIGR00895
196627008345	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627008346	putative substrate translocation pore; other site
196627008347	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627008348	Predicted transcriptional regulators [Transcription]; Region: COG1695
196627008349	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
196627008350	replicative DNA helicase; Provisional; Region: PRK05636
196627008351	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
196627008352	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
196627008353	Walker A motif; other site
196627008354	ATP binding site [chemical binding]; other site
196627008355	Walker B motif; other site
196627008356	DNA binding loops [nucleotide binding]
196627008357	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
196627008358	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
196627008359	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
196627008360	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
196627008361	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
196627008362	dimer interface [polypeptide binding]; other site
196627008363	ssDNA binding site [nucleotide binding]; other site
196627008364	tetramer (dimer of dimers) interface [polypeptide binding]; other site
196627008365	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
196627008366	Predicted integral membrane protein [Function unknown]; Region: COG5650
196627008367	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
196627008368	Transglycosylase; Region: Transgly; pfam00912
196627008369	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
196627008370	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
196627008371	MarR family; Region: MarR; pfam01047
196627008372	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
196627008373	Ligand Binding Site [chemical binding]; other site
196627008374	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
196627008375	Ligand Binding Site [chemical binding]; other site
196627008376	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
196627008377	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
196627008378	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
196627008379	active site residue [active]
196627008380	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
196627008381	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
196627008382	FtsX-like permease family; Region: FtsX; pfam02687
196627008383	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
196627008384	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
196627008385	Walker A/P-loop; other site
196627008386	ATP binding site [chemical binding]; other site
196627008387	Q-loop/lid; other site
196627008388	ABC transporter signature motif; other site
196627008389	Walker B; other site
196627008390	D-loop; other site
196627008391	H-loop/switch region; other site
196627008392	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
196627008393	HlyD family secretion protein; Region: HlyD_3; pfam13437
196627008394	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
196627008395	inositol 1-phosphate synthase, Actinobacterial type; Region: mycothiol_INO1; TIGR03450
196627008396	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
196627008397	hypothetical protein; Provisional; Region: PRK13663
196627008398	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
196627008399	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
196627008400	dimerization interface [polypeptide binding]; other site
196627008401	DPS ferroxidase diiron center [ion binding]; other site
196627008402	ion pore; other site
196627008403	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
196627008404	N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970
196627008405	putative DNA binding site [nucleotide binding]; other site
196627008406	catalytic residue [active]
196627008407	putative H2TH interface [polypeptide binding]; other site
196627008408	putative catalytic residues [active]
196627008409	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
196627008410	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
196627008411	hypothetical protein; Reviewed; Region: PRK09588
196627008412	Uncharacterized conserved protein [Function unknown]; Region: COG1434
196627008413	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
196627008414	putative active site [active]
196627008415	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
196627008416	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
196627008417	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
196627008418	DNA binding site [nucleotide binding]
196627008419	active site
196627008420	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
196627008421	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
196627008422	putative NAD(P) binding site [chemical binding]; other site
196627008423	dimer interface [polypeptide binding]; other site
196627008424	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
196627008425	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627008426	putative substrate translocation pore; other site
196627008427	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
196627008428	Malic enzyme, N-terminal domain; Region: malic; pfam00390
196627008429	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
196627008430	putative NAD(P) binding site [chemical binding]; other site
196627008431	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
196627008432	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
196627008433	N- and C-terminal domain interface [polypeptide binding]; other site
196627008434	active site
196627008435	catalytic site [active]
196627008436	metal binding site [ion binding]; metal-binding site
196627008437	carbohydrate binding site [chemical binding]; other site
196627008438	ATP binding site [chemical binding]; other site
196627008439	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
196627008440	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
196627008441	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
196627008442	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
196627008443	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
196627008444	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
196627008445	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
196627008446	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
196627008447	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
196627008448	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
196627008449	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
196627008450	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
196627008451	putative FMN binding site [chemical binding]; other site
196627008452	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
196627008453	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
196627008454	HIGH motif; other site
196627008455	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
196627008456	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
196627008457	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
196627008458	active site
196627008459	KMSKS motif; other site
196627008460	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
196627008461	tRNA binding surface [nucleotide binding]; other site
196627008462	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
196627008463	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
196627008464	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
196627008465	non-specific DNA binding site [nucleotide binding]; other site
196627008466	salt bridge; other site
196627008467	sequence-specific DNA binding site [nucleotide binding]; other site
196627008468	mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583
196627008469	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
196627008470	MDMPI C-terminal domain; Region: MDMPI_C; pfam07398
196627008471	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
196627008472	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
196627008473	Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435
196627008474	Cupin domain; Region: Cupin_2; pfam07883
196627008475	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
196627008476	Transcriptional regulator [Transcription]; Region: IclR; COG1414
196627008477	Bacterial transcriptional regulator; Region: IclR; pfam01614
196627008478	benzoate transport; Region: 2A0115; TIGR00895
196627008479	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627008480	putative substrate translocation pore; other site
196627008481	salicylate hydroxylase; Provisional; Region: PRK08163
196627008482	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
196627008483	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
196627008484	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
196627008485	SdpI/YhfL protein family; Region: SdpI; pfam13630
196627008486	Predicted integral membrane protein [Function unknown]; Region: COG5658
196627008487	anthranilate synthase component I; Provisional; Region: PRK13564
196627008488	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
196627008489	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
196627008490	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
196627008491	Glutamine amidotransferase class-I; Region: GATase; pfam00117
196627008492	glutamine binding [chemical binding]; other site
196627008493	catalytic triad [active]
196627008494	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
196627008495	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
196627008496	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
196627008497	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
196627008498	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
196627008499	active site
196627008500	ribulose/triose binding site [chemical binding]; other site
196627008501	phosphate binding site [ion binding]; other site
196627008502	substrate (anthranilate) binding pocket [chemical binding]; other site
196627008503	product (indole) binding pocket [chemical binding]; other site
196627008504	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
196627008505	active site
196627008506	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
196627008507	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
196627008508	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196627008509	catalytic residue [active]
196627008510	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
196627008511	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
196627008512	substrate binding site [chemical binding]; other site
196627008513	active site
196627008514	catalytic residues [active]
196627008515	heterodimer interface [polypeptide binding]; other site
196627008516	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
196627008517	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
196627008518	active site
196627008519	phosphorylation site [posttranslational modification]
196627008520	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
196627008521	active site
196627008522	P-loop; other site
196627008523	phosphorylation site [posttranslational modification]
196627008524	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
196627008525	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
196627008526	Walker A/P-loop; other site
196627008527	ATP binding site [chemical binding]; other site
196627008528	Q-loop/lid; other site
196627008529	ABC transporter signature motif; other site
196627008530	Walker B; other site
196627008531	D-loop; other site
196627008532	H-loop/switch region; other site
196627008533	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
196627008534	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
196627008535	iron-sulfur cluster [ion binding]; other site
196627008536	[2Fe-2S] cluster binding site [ion binding]; other site
196627008537	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
196627008538	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
196627008539	active site
196627008540	FMN binding site [chemical binding]; other site
196627008541	substrate binding site [chemical binding]; other site
196627008542	homotetramer interface [polypeptide binding]; other site
196627008543	catalytic residue [active]
196627008544	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
196627008545	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
196627008546	Uncharacterized conserved protein [Function unknown]; Region: COG3358
196627008547	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196627008548	putative DNA binding site [nucleotide binding]; other site
196627008549	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
196627008550	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
196627008551	active site
196627008552	FMN binding site [chemical binding]; other site
196627008553	substrate binding site [chemical binding]; other site
196627008554	homotetramer interface [polypeptide binding]; other site
196627008555	catalytic residue [active]
196627008556	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
196627008557	NADH(P)-binding; Region: NAD_binding_10; pfam13460
196627008558	NAD(P) binding site [chemical binding]; other site
196627008559	putative active site [active]
196627008560	short chain dehydrogenase; Provisional; Region: PRK08267
196627008561	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196627008562	NAD(P) binding site [chemical binding]; other site
196627008563	active site
196627008564	mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416
196627008565	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
196627008566	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
196627008567	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627008568	putative substrate translocation pore; other site
196627008569	POT family; Region: PTR2; cl17359
196627008570	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196627008571	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
196627008572	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
196627008573	active site
196627008574	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
196627008575	Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177
196627008576	active site
196627008577	dimer interface [polypeptide binding]; other site
196627008578	metal binding site [ion binding]; metal-binding site
196627008579	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
196627008580	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627008581	putative substrate translocation pore; other site
196627008582	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627008583	Transcriptional regulator [Transcription]; Region: IclR; COG1414
196627008584	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
196627008585	Transcriptional regulator [Transcription]; Region: IclR; COG1414
196627008586	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
196627008587	Bacterial transcriptional regulator; Region: IclR; pfam01614
196627008588	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
196627008589	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
196627008590	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
196627008591	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
196627008592	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
196627008593	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
196627008594	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
196627008595	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
196627008596	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
196627008597	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
196627008598	Lamin Tail Domain; Region: LTD; pfam00932
196627008599	Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750
196627008600	Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399
196627008601	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
196627008602	putative active site [active]
196627008603	putative metal binding site [ion binding]; other site
196627008604	proline/glycine betaine transporter; Provisional; Region: PRK10642
196627008605	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627008606	putative substrate translocation pore; other site
196627008607	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
196627008608	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
196627008609	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719
196627008610	GIY-YIG motif/motif A; other site
196627008611	active site
196627008612	catalytic site [active]
196627008613	metal binding site [ion binding]; metal-binding site
196627008614	Predicted helicase [General function prediction only]; Region: COG4889
196627008615	Restriction endonuclease; Region: Mrr_cat_2; pfam13156
196627008616	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196627008617	ATP binding site [chemical binding]; other site
196627008618	putative Mg++ binding site [ion binding]; other site
196627008619	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196627008620	ATP-binding site [chemical binding]; other site
196627008621	Domain of unknown function (DUF4395); Region: DUF4395; pfam14340
196627008622	Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [Coenzyme metabolism]; Region: ThiD; COG0351
196627008623	ATP binding site [chemical binding]; other site
196627008624	substrate binding site [chemical binding]; other site
196627008625	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cl01497
196627008626	DNA binding site [nucleotide binding]
196627008627	active site
196627008628	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
196627008629	metal-binding site [ion binding]
196627008630	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196627008631	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
196627008632	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
196627008633	siderophore binding site; other site
196627008634	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
196627008635	2-enoyl thioester reductase (ETR) like proteins, child 2; Region: ETR_like_2; cd08292
196627008636	putative NAD(P) binding site [chemical binding]; other site
196627008637	putative dimer interface [polypeptide binding]; other site
196627008638	Predicted membrane protein [Function unknown]; Region: COG3759
196627008639	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
196627008640	substrate binding site [chemical binding]; other site
196627008641	dimer interface [polypeptide binding]; other site
196627008642	ATP binding site [chemical binding]; other site
196627008643	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
196627008644	metal-binding site [ion binding]
196627008645	Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687
196627008646	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
196627008647	hypothetical protein; Validated; Region: PRK00228
196627008648	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
196627008649	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
196627008650	active site
196627008651	NTP binding site [chemical binding]; other site
196627008652	metal binding triad [ion binding]; metal-binding site
196627008653	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
196627008654	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
196627008655	Zn2+ binding site [ion binding]; other site
196627008656	Mg2+ binding site [ion binding]; other site
196627008657	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
196627008658	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
196627008659	active site
196627008660	Ap6A binding site [chemical binding]; other site
196627008661	nudix motif; other site
196627008662	metal binding site [ion binding]; metal-binding site
196627008663	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
196627008664	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
196627008665	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
196627008666	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
196627008667	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196627008668	DNA binding residues [nucleotide binding]
196627008669	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
196627008670	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
196627008671	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
196627008672	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
196627008673	catalytic residues [active]
196627008674	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
196627008675	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
196627008676	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
196627008677	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
196627008678	active site
196627008679	metal binding site [ion binding]; metal-binding site
196627008680	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
196627008681	ParB-like nuclease domain; Region: ParB; smart00470
196627008682	KorB domain; Region: KorB; pfam08535
196627008683	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
196627008684	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
196627008685	P-loop; other site
196627008686	Magnesium ion binding site [ion binding]; other site
196627008687	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
196627008688	Magnesium ion binding site [ion binding]; other site
196627008689	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
196627008690	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
196627008691	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
196627008692	putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449
196627008693	Haemolytic domain; Region: Haemolytic; pfam01809
196627008694	ribonuclease P; Reviewed; Region: rnpA; PRK03459