-- dump date 20140619_051750 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1232383000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1232383000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232383000003 Walker A motif; other site 1232383000004 ATP binding site [chemical binding]; other site 1232383000005 Walker B motif; other site 1232383000006 arginine finger; other site 1232383000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1232383000008 DnaA box-binding interface [nucleotide binding]; other site 1232383000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1232383000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1232383000011 putative DNA binding surface [nucleotide binding]; other site 1232383000012 dimer interface [polypeptide binding]; other site 1232383000013 beta-clamp/clamp loader binding surface; other site 1232383000014 beta-clamp/translesion DNA polymerase binding surface; other site 1232383000015 recombination protein F; Reviewed; Region: recF; PRK00064 1232383000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1232383000017 Walker A/P-loop; other site 1232383000018 ATP binding site [chemical binding]; other site 1232383000019 Q-loop/lid; other site 1232383000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232383000021 ABC transporter signature motif; other site 1232383000022 Walker B; other site 1232383000023 D-loop; other site 1232383000024 H-loop/switch region; other site 1232383000025 hypothetical protein; Provisional; Region: PRK00111 1232383000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1232383000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232383000028 ATP binding site [chemical binding]; other site 1232383000029 Mg2+ binding site [ion binding]; other site 1232383000030 G-X-G motif; other site 1232383000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1232383000032 anchoring element; other site 1232383000033 dimer interface [polypeptide binding]; other site 1232383000034 ATP binding site [chemical binding]; other site 1232383000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1232383000036 active site 1232383000037 putative metal-binding site [ion binding]; other site 1232383000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1232383000039 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 1232383000040 Predicted membrane protein [Function unknown]; Region: COG2364 1232383000041 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1232383000042 DNA gyrase subunit A; Validated; Region: PRK05560 1232383000043 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1232383000044 CAP-like domain; other site 1232383000045 active site 1232383000046 primary dimer interface [polypeptide binding]; other site 1232383000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1232383000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1232383000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1232383000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1232383000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1232383000052 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1232383000053 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1232383000054 Amino acid permease; Region: AA_permease; pfam00324 1232383000055 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1232383000056 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1232383000057 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1232383000058 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1232383000059 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1232383000060 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1232383000061 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 1232383000062 NAD(P) binding site [chemical binding]; other site 1232383000063 catalytic residues [active] 1232383000064 Predicted membrane protein [Function unknown]; Region: COG2855 1232383000065 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1232383000066 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1232383000067 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1232383000068 dimerization interface [polypeptide binding]; other site 1232383000069 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1232383000070 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1232383000071 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1232383000072 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1232383000073 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1232383000074 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1232383000075 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1232383000076 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1232383000077 active site 1232383000078 metal binding site [ion binding]; metal-binding site 1232383000079 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1232383000080 Protein of unknown function (DUF418); Region: DUF418; cl12135 1232383000081 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1232383000082 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1232383000083 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1232383000084 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1232383000085 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1232383000086 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1232383000087 putative active site [active] 1232383000088 putative metal binding site [ion binding]; other site 1232383000089 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 1232383000090 putative ADP-binding pocket [chemical binding]; other site 1232383000091 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1232383000092 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1232383000093 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1232383000094 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1232383000095 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1232383000096 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1232383000097 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1232383000098 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1232383000099 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 1232383000100 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1232383000101 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 1232383000102 Divergent AAA domain; Region: AAA_4; pfam04326 1232383000103 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1232383000104 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1232383000105 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1232383000106 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1232383000107 intersubunit interface [polypeptide binding]; other site 1232383000108 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1232383000109 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1232383000110 ABC-ATPase subunit interface; other site 1232383000111 dimer interface [polypeptide binding]; other site 1232383000112 putative PBP binding regions; other site 1232383000113 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1232383000114 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232383000115 Walker A/P-loop; other site 1232383000116 ATP binding site [chemical binding]; other site 1232383000117 Q-loop/lid; other site 1232383000118 ABC transporter signature motif; other site 1232383000119 Walker B; other site 1232383000120 D-loop; other site 1232383000121 H-loop/switch region; other site 1232383000122 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 1232383000123 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1232383000124 putative ligand binding site [chemical binding]; other site 1232383000125 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1232383000126 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1232383000127 TM-ABC transporter signature motif; other site 1232383000128 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1232383000129 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1232383000130 Walker A/P-loop; other site 1232383000131 ATP binding site [chemical binding]; other site 1232383000132 Q-loop/lid; other site 1232383000133 ABC transporter signature motif; other site 1232383000134 Walker B; other site 1232383000135 D-loop; other site 1232383000136 H-loop/switch region; other site 1232383000137 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1232383000138 active site 1232383000139 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1232383000140 potential frameshift: common BLAST hit: gi|62388931|ref|YP_224333.1| transcription regulator protein, AraC typ 1232383000141 phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098 1232383000142 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 1232383000143 putative septation inhibitor protein; Reviewed; Region: PRK00159 1232383000144 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1232383000145 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1232383000146 active site 1232383000147 ATP binding site [chemical binding]; other site 1232383000148 substrate binding site [chemical binding]; other site 1232383000149 activation loop (A-loop); other site 1232383000150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1232383000151 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1232383000152 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1232383000153 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1232383000154 PASTA domain; Region: PASTA; pfam03793 1232383000155 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1232383000156 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1232383000157 active site 1232383000158 ATP binding site [chemical binding]; other site 1232383000159 substrate binding site [chemical binding]; other site 1232383000160 activation loop (A-loop); other site 1232383000161 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1232383000162 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1232383000163 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1232383000164 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1232383000165 Protein phosphatase 2C; Region: PP2C; pfam00481 1232383000166 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1232383000167 active site 1232383000168 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1232383000169 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1232383000170 phosphopeptide binding site; other site 1232383000171 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1232383000172 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1232383000173 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1232383000174 phosphopeptide binding site; other site 1232383000175 succinic semialdehyde dehydrogenase; Region: PLN02278 1232383000176 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1232383000177 tetramerization interface [polypeptide binding]; other site 1232383000178 NAD(P) binding site [chemical binding]; other site 1232383000179 catalytic residues [active] 1232383000180 potential frameshift: common BLAST hit: gi|62388946|ref|YP_224348.1| phenol 2-monooxygenase 1232383000181 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1232383000182 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1232383000183 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1232383000184 active site residue [active] 1232383000185 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1232383000186 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1232383000187 active site residue [active] 1232383000188 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1232383000189 active site residue [active] 1232383000190 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1232383000191 putative homodimer interface [polypeptide binding]; other site 1232383000192 putative homotetramer interface [polypeptide binding]; other site 1232383000193 putative allosteric switch controlling residues; other site 1232383000194 putative metal binding site [ion binding]; other site 1232383000195 putative homodimer-homodimer interface [polypeptide binding]; other site 1232383000196 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 1232383000197 putative metal binding residues [ion binding]; other site 1232383000198 signature motif; other site 1232383000199 dimer interface [polypeptide binding]; other site 1232383000200 active site 1232383000201 polyP binding site; other site 1232383000202 substrate binding site [chemical binding]; other site 1232383000203 acceptor-phosphate pocket; other site 1232383000204 MgtC family; Region: MgtC; pfam02308 1232383000205 Spore coat assembly protein [Cell envelope biogenesis, outer membrane]; Region: CotH; COG5337 1232383000206 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1232383000207 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1232383000208 oligomer interface [polypeptide binding]; other site 1232383000209 metal binding site [ion binding]; metal-binding site 1232383000210 metal binding site [ion binding]; metal-binding site 1232383000211 putative Cl binding site [ion binding]; other site 1232383000212 basic sphincter; other site 1232383000213 hydrophobic gate; other site 1232383000214 periplasmic entrance; other site 1232383000215 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 1232383000216 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1232383000217 dimer interface [polypeptide binding]; other site 1232383000218 hexamer interface [polypeptide binding]; other site 1232383000219 active site 2 [active] 1232383000220 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1232383000221 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 1232383000222 putative ion selectivity filter; other site 1232383000223 putative pore gating glutamate residue; other site 1232383000224 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 1232383000225 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1232383000226 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1232383000227 putative active site [active] 1232383000228 PhoH-like protein; Region: PhoH; pfam02562 1232383000229 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1232383000230 Citrate transporter; Region: CitMHS; pfam03600 1232383000231 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1232383000232 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1232383000233 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232383000234 ATP binding site [chemical binding]; other site 1232383000235 Mg2+ binding site [ion binding]; other site 1232383000236 G-X-G motif; other site 1232383000237 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1232383000238 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1232383000239 active site 1232383000240 phosphorylation site [posttranslational modification] 1232383000241 intermolecular recognition site; other site 1232383000242 dimerization interface [polypeptide binding]; other site 1232383000243 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1232383000244 putative DNA binding site [nucleotide binding]; other site 1232383000245 putative Zn2+ binding site [ion binding]; other site 1232383000246 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1232383000247 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 1232383000248 putative ligand binding site [chemical binding]; other site 1232383000249 putative NAD binding site [chemical binding]; other site 1232383000250 catalytic site [active] 1232383000251 biotin synthase; Validated; Region: PRK06256 1232383000252 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1232383000253 FeS/SAM binding site; other site 1232383000254 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1232383000255 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 1232383000256 CHY zinc finger; Region: zf-CHY; pfam05495 1232383000257 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1232383000258 cytosine deaminase; Provisional; Region: PRK09230 1232383000259 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1232383000260 active site 1232383000261 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1232383000262 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1232383000263 Lipase (class 2); Region: Lipase_2; pfam01674 1232383000264 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1232383000265 Lipase (class 2); Region: Lipase_2; pfam01674 1232383000266 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1232383000267 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1232383000268 putative DNA binding site [nucleotide binding]; other site 1232383000269 putative Zn2+ binding site [ion binding]; other site 1232383000270 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1232383000271 alpha-gamma subunit interface [polypeptide binding]; other site 1232383000272 beta-gamma subunit interface [polypeptide binding]; other site 1232383000273 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1232383000274 gamma-beta subunit interface [polypeptide binding]; other site 1232383000275 alpha-beta subunit interface [polypeptide binding]; other site 1232383000276 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1232383000277 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1232383000278 subunit interactions [polypeptide binding]; other site 1232383000279 active site 1232383000280 flap region; other site 1232383000281 Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371 1232383000282 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1232383000283 dimer interface [polypeptide binding]; other site 1232383000284 catalytic residues [active] 1232383000285 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1232383000286 UreF; Region: UreF; pfam01730 1232383000287 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1232383000288 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 1232383000289 HSP90 family protein; Provisional; Region: PRK14083 1232383000290 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232383000291 ATP binding site [chemical binding]; other site 1232383000292 Mg2+ binding site [ion binding]; other site 1232383000293 G-X-G motif; other site 1232383000294 AMP nucleosidase; Region: AMP-nucleosdse; TIGR01717 1232383000295 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1232383000296 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1232383000297 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1232383000298 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1232383000299 NAD(P) binding site [chemical binding]; other site 1232383000300 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1232383000301 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1232383000302 DNA binding site [nucleotide binding] 1232383000303 domain linker motif; other site 1232383000304 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1232383000305 dimerization interface [polypeptide binding]; other site 1232383000306 ligand binding site [chemical binding]; other site 1232383000307 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1232383000308 histidinol dehydrogenase; Region: hisD; TIGR00069 1232383000309 NAD binding site [chemical binding]; other site 1232383000310 dimerization interface [polypeptide binding]; other site 1232383000311 product binding site; other site 1232383000312 substrate binding site [chemical binding]; other site 1232383000313 zinc binding site [ion binding]; other site 1232383000314 catalytic residues [active] 1232383000315 Citrate transporter; Region: CitMHS; pfam03600 1232383000316 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1232383000317 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1232383000318 Integrase core domain; Region: rve; pfam00665 1232383000319 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1232383000320 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1232383000321 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1232383000322 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1232383000323 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1232383000324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1232383000325 active site 1232383000326 phosphorylation site [posttranslational modification] 1232383000327 intermolecular recognition site; other site 1232383000328 dimerization interface [polypeptide binding]; other site 1232383000329 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1232383000330 DNA binding site [nucleotide binding] 1232383000331 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1232383000332 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1232383000333 dimerization interface [polypeptide binding]; other site 1232383000334 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1232383000335 dimer interface [polypeptide binding]; other site 1232383000336 phosphorylation site [posttranslational modification] 1232383000337 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232383000338 ATP binding site [chemical binding]; other site 1232383000339 Mg2+ binding site [ion binding]; other site 1232383000340 G-X-G motif; other site 1232383000341 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1232383000342 metal-binding site [ion binding] 1232383000343 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1232383000344 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1232383000345 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232383000346 motif I; other site 1232383000347 motif II; other site 1232383000348 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1232383000349 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1232383000350 AsnC family; Region: AsnC_trans_reg; pfam01037 1232383000351 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1232383000352 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1232383000353 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1232383000354 NAD(P) binding site [chemical binding]; other site 1232383000355 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1232383000356 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1232383000357 catalytic residues [active] 1232383000358 catalytic nucleophile [active] 1232383000359 Presynaptic Site I dimer interface [polypeptide binding]; other site 1232383000360 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1232383000361 Synaptic Flat tetramer interface [polypeptide binding]; other site 1232383000362 Synaptic Site I dimer interface [polypeptide binding]; other site 1232383000363 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1232383000364 DNA-binding interface [nucleotide binding]; DNA binding site 1232383000365 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1232383000366 dimerization interface [polypeptide binding]; other site 1232383000367 putative DNA binding site [nucleotide binding]; other site 1232383000368 putative Zn2+ binding site [ion binding]; other site 1232383000369 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 1232383000370 Cadmium resistance transporter; Region: Cad; pfam03596 1232383000371 mercuric reductase; Region: MerA; TIGR02053 1232383000372 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232383000373 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1232383000374 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1232383000375 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1232383000376 DNA binding residues [nucleotide binding] 1232383000377 dimer interface [polypeptide binding]; other site 1232383000378 metal binding site [ion binding]; metal-binding site 1232383000379 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1232383000380 salt bridge; other site 1232383000381 non-specific DNA binding site [nucleotide binding]; other site 1232383000382 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1232383000383 sequence-specific DNA binding site [nucleotide binding]; other site 1232383000384 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1232383000385 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1232383000386 active site 1232383000387 catalytic tetrad [active] 1232383000388 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232383000389 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1232383000390 Walker A motif; other site 1232383000391 ATP binding site [chemical binding]; other site 1232383000392 Walker B motif; other site 1232383000393 arginine finger; other site 1232383000394 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 1232383000395 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1232383000396 Integrase core domain; Region: rve; pfam00665 1232383000397 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1232383000398 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1232383000399 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1232383000400 NAD(P) binding site [chemical binding]; other site 1232383000401 catalytic residues [active] 1232383000402 hypothetical protein; Validated; Region: PRK09039 1232383000403 Integrase core domain; Region: rve; pfam00665 1232383000404 Integrase core domain; Region: rve_3; pfam13683 1232383000405 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1232383000406 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1232383000407 active site 1232383000408 catalytic tetrad [active] 1232383000409 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 1232383000410 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1232383000411 amidohydrolase; Region: amidohydrolases; TIGR01891 1232383000412 metal binding site [ion binding]; metal-binding site 1232383000413 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1232383000414 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1232383000415 tetramer interface [polypeptide binding]; other site 1232383000416 active site 1232383000417 Mg2+/Mn2+ binding site [ion binding]; other site 1232383000418 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232383000419 Cytochrome P450; Region: p450; cl12078 1232383000420 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1232383000421 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232383000422 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1232383000423 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1232383000424 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1232383000425 classical (c) SDRs; Region: SDR_c; cd05233 1232383000426 NAD(P) binding site [chemical binding]; other site 1232383000427 active site 1232383000428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383000429 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1232383000430 putative substrate translocation pore; other site 1232383000431 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 1232383000432 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1232383000433 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1232383000434 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1232383000435 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1232383000436 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1232383000437 DNA-binding site [nucleotide binding]; DNA binding site 1232383000438 FCD domain; Region: FCD; pfam07729 1232383000439 Htaa; Region: HtaA; pfam04213 1232383000440 choline dehydrogenase; Validated; Region: PRK02106 1232383000441 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1232383000442 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232383000443 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232383000444 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1232383000445 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1232383000446 NAD binding site [chemical binding]; other site 1232383000447 catalytic residues [active] 1232383000448 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232383000449 Cytochrome P450; Region: p450; cl12078 1232383000450 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1232383000451 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1232383000452 DctM-like transporters; Region: DctM; pfam06808 1232383000453 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1232383000454 Htaa; Region: HtaA; pfam04213 1232383000455 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1232383000456 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1232383000457 NAD binding site [chemical binding]; other site 1232383000458 catalytic residues [active] 1232383000459 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1232383000460 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1232383000461 NAD binding site [chemical binding]; other site 1232383000462 catalytic Zn binding site [ion binding]; other site 1232383000463 substrate binding site [chemical binding]; other site 1232383000464 structural Zn binding site [ion binding]; other site 1232383000465 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1232383000466 substrate binding pocket [chemical binding]; other site 1232383000467 dimerization interface [polypeptide binding]; other site 1232383000468 Predicted membrane protein [Function unknown]; Region: COG2149 1232383000469 Domain of unknown function (DUF202); Region: DUF202; pfam02656 1232383000470 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1232383000471 non-specific DNA binding site [nucleotide binding]; other site 1232383000472 salt bridge; other site 1232383000473 sequence-specific DNA binding site [nucleotide binding]; other site 1232383000474 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1232383000475 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1232383000476 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1232383000477 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1232383000478 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1232383000479 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1232383000480 catalytic core [active] 1232383000481 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1232383000482 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1232383000483 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1232383000484 polyol permease family; Region: 2A0118; TIGR00897 1232383000485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383000486 putative substrate translocation pore; other site 1232383000487 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1232383000488 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1232383000489 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1232383000490 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1232383000491 D-xylulose kinase; Region: XylB; TIGR01312 1232383000492 nucleotide binding site [chemical binding]; other site 1232383000493 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1232383000494 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1232383000495 active site 1232383000496 ATP-binding site [chemical binding]; other site 1232383000497 pantoate-binding site; other site 1232383000498 HXXH motif; other site 1232383000499 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1232383000500 oligomerization interface [polypeptide binding]; other site 1232383000501 active site 1232383000502 metal binding site [ion binding]; metal-binding site 1232383000503 Fic family protein [Function unknown]; Region: COG3177 1232383000504 Fic/DOC family; Region: Fic; pfam02661 1232383000505 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1232383000506 active site 1232383000507 DNA binding site [nucleotide binding] 1232383000508 hypothetical protein; Provisional; Region: PRK07758 1232383000509 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1232383000510 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1232383000511 substrate binding pocket [chemical binding]; other site 1232383000512 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1232383000513 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232383000514 motif II; other site 1232383000515 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1232383000516 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1232383000517 trimer interface [polypeptide binding]; other site 1232383000518 putative metal binding site [ion binding]; other site 1232383000519 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1232383000520 putative DNA binding site [nucleotide binding]; other site 1232383000521 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1232383000522 enterobactin exporter EntS; Provisional; Region: PRK10489 1232383000523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383000524 putative substrate translocation pore; other site 1232383000525 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1232383000526 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1232383000527 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 1232383000528 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1232383000529 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1232383000530 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1232383000531 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1232383000532 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1232383000533 active site 1232383000534 intersubunit interface [polypeptide binding]; other site 1232383000535 catalytic residue [active] 1232383000536 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383000537 D-galactonate transporter; Region: 2A0114; TIGR00893 1232383000538 putative substrate translocation pore; other site 1232383000539 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 1232383000540 AAA domain; Region: AAA_17; pfam13207 1232383000541 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1232383000542 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1232383000543 Predicted membrane protein [Function unknown]; Region: COG2860 1232383000544 UPF0126 domain; Region: UPF0126; pfam03458 1232383000545 Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187 1232383000546 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1232383000547 tetramerization interface [polypeptide binding]; other site 1232383000548 active site 1232383000549 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805 1232383000550 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1232383000551 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1232383000552 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1232383000553 hypothetical protein; Provisional; Region: PRK10621 1232383000554 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1232383000555 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 1232383000556 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1232383000557 putative Mg++ binding site [ion binding]; other site 1232383000558 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1232383000559 nucleotide binding region [chemical binding]; other site 1232383000560 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 1232383000561 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1232383000562 maltose O-acetyltransferase; Provisional; Region: PRK10092 1232383000563 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1232383000564 active site 1232383000565 substrate binding site [chemical binding]; other site 1232383000566 trimer interface [polypeptide binding]; other site 1232383000567 CoA binding site [chemical binding]; other site 1232383000568 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 1232383000569 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 1232383000570 potential frameshift: common BLAST hit: gi|62389040|ref|YP_224442.1| LysE type translocator 1232383000571 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1232383000572 RNA binding surface [nucleotide binding]; other site 1232383000573 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1232383000574 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1232383000575 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1232383000576 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1232383000577 DNA binding site [nucleotide binding] 1232383000578 active site 1232383000579 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1232383000580 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1232383000581 homotrimer interaction site [polypeptide binding]; other site 1232383000582 putative active site [active] 1232383000583 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1232383000584 DHHC palmitoyltransferase; Region: zf-DHHC; pfam01529 1232383000585 Histidine kinase; Region: HisKA_3; pfam07730 1232383000586 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1232383000587 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1232383000588 active site 1232383000589 phosphorylation site [posttranslational modification] 1232383000590 intermolecular recognition site; other site 1232383000591 dimerization interface [polypeptide binding]; other site 1232383000592 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1232383000593 DNA binding residues [nucleotide binding] 1232383000594 dimerization interface [polypeptide binding]; other site 1232383000595 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1232383000596 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1232383000597 active site 1232383000598 Zn binding site [ion binding]; other site 1232383000599 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 1232383000600 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1232383000601 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1232383000602 DNA-binding site [nucleotide binding]; DNA binding site 1232383000603 UTRA domain; Region: UTRA; pfam07702 1232383000604 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1232383000605 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1232383000606 substrate binding site [chemical binding]; other site 1232383000607 ATP binding site [chemical binding]; other site 1232383000608 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1232383000609 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1232383000610 tetrameric interface [polypeptide binding]; other site 1232383000611 NAD binding site [chemical binding]; other site 1232383000612 catalytic residues [active] 1232383000613 KduI/IolB family; Region: KduI; cl01508 1232383000614 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1232383000615 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1232383000616 PYR/PP interface [polypeptide binding]; other site 1232383000617 dimer interface [polypeptide binding]; other site 1232383000618 TPP binding site [chemical binding]; other site 1232383000619 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1232383000620 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1232383000621 TPP-binding site; other site 1232383000622 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1232383000623 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1232383000624 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1232383000625 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1232383000626 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1232383000627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383000628 putative transporter; Provisional; Region: PRK10504 1232383000629 putative substrate translocation pore; other site 1232383000630 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1232383000631 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1232383000632 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1232383000633 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1232383000634 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1232383000635 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1232383000636 DNA binding site [nucleotide binding] 1232383000637 domain linker motif; other site 1232383000638 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1232383000639 dimerization interface [polypeptide binding]; other site 1232383000640 ligand binding site [chemical binding]; other site 1232383000641 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1232383000642 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1232383000643 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1232383000644 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1232383000645 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1232383000646 DNA-binding site [nucleotide binding]; DNA binding site 1232383000647 RNA-binding motif; other site 1232383000648 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1232383000649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232383000650 dimer interface [polypeptide binding]; other site 1232383000651 conserved gate region; other site 1232383000652 putative PBP binding loops; other site 1232383000653 ABC-ATPase subunit interface; other site 1232383000654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232383000655 dimer interface [polypeptide binding]; other site 1232383000656 conserved gate region; other site 1232383000657 putative PBP binding loops; other site 1232383000658 ABC-ATPase subunit interface; other site 1232383000659 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1232383000660 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232383000661 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1232383000662 Walker A/P-loop; other site 1232383000663 ATP binding site [chemical binding]; other site 1232383000664 Q-loop/lid; other site 1232383000665 ABC transporter signature motif; other site 1232383000666 Walker B; other site 1232383000667 D-loop; other site 1232383000668 H-loop/switch region; other site 1232383000669 TOBE domain; Region: TOBE_2; pfam08402 1232383000670 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1232383000671 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232383000672 motif II; other site 1232383000673 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1232383000674 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1232383000675 DNA binding site [nucleotide binding] 1232383000676 domain linker motif; other site 1232383000677 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1232383000678 dimerization interface [polypeptide binding]; other site 1232383000679 ligand binding site [chemical binding]; other site 1232383000680 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1232383000681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232383000682 S-adenosylmethionine binding site [chemical binding]; other site 1232383000683 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1232383000684 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1232383000685 Coenzyme A binding pocket [chemical binding]; other site 1232383000686 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1232383000687 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1232383000688 DNA binding site [nucleotide binding] 1232383000689 domain linker motif; other site 1232383000690 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1232383000691 dimerization interface [polypeptide binding]; other site 1232383000692 ligand binding site [chemical binding]; other site 1232383000693 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1232383000694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383000695 putative substrate translocation pore; other site 1232383000696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383000697 hypothetical protein; Validated; Region: PRK09039 1232383000698 Integrase core domain; Region: rve; pfam00665 1232383000699 Integrase core domain; Region: rve_3; pfam13683 1232383000700 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1232383000701 PAS domain; Region: PAS_9; pfam13426 1232383000702 putative active site [active] 1232383000703 heme pocket [chemical binding]; other site 1232383000704 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1232383000705 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1232383000706 active site 1232383000707 dimer interface [polypeptide binding]; other site 1232383000708 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1232383000709 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1232383000710 active site 1232383000711 FMN binding site [chemical binding]; other site 1232383000712 substrate binding site [chemical binding]; other site 1232383000713 3Fe-4S cluster binding site [ion binding]; other site 1232383000714 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1232383000715 domain interface; other site 1232383000716 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1232383000717 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1232383000718 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1232383000719 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1232383000720 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 1232383000721 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 1232383000722 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1232383000723 classical (c) SDRs; Region: SDR_c; cd05233 1232383000724 NAD(P) binding site [chemical binding]; other site 1232383000725 active site 1232383000726 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1232383000727 FAD binding domain; Region: FAD_binding_4; pfam01565 1232383000728 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1232383000729 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 1232383000730 Predicted membrane protein [Function unknown]; Region: COG2246 1232383000731 GtrA-like protein; Region: GtrA; pfam04138 1232383000732 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1232383000733 MOSC domain; Region: MOSC; pfam03473 1232383000734 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1232383000735 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1232383000736 active site 1232383000737 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1232383000738 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1232383000739 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1232383000740 Walker A/P-loop; other site 1232383000741 ATP binding site [chemical binding]; other site 1232383000742 Q-loop/lid; other site 1232383000743 ABC transporter signature motif; other site 1232383000744 Walker B; other site 1232383000745 D-loop; other site 1232383000746 H-loop/switch region; other site 1232383000747 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1232383000748 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1232383000749 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1232383000750 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1232383000751 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1232383000752 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1232383000753 NAD(P) binding site [chemical binding]; other site 1232383000754 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1232383000755 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1232383000756 catalytic loop [active] 1232383000757 iron binding site [ion binding]; other site 1232383000758 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1232383000759 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1232383000760 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1232383000761 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK05597 1232383000762 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1232383000763 ATP binding site [chemical binding]; other site 1232383000764 substrate interface [chemical binding]; other site 1232383000765 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1232383000766 active site residue [active] 1232383000767 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1232383000768 MoaE homodimer interface [polypeptide binding]; other site 1232383000769 MoaD interaction [polypeptide binding]; other site 1232383000770 active site residues [active] 1232383000771 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1232383000772 MPT binding site; other site 1232383000773 trimer interface [polypeptide binding]; other site 1232383000774 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1232383000775 trimer interface [polypeptide binding]; other site 1232383000776 dimer interface [polypeptide binding]; other site 1232383000777 putative active site [active] 1232383000778 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1232383000779 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1232383000780 dimer interface [polypeptide binding]; other site 1232383000781 putative functional site; other site 1232383000782 putative MPT binding site; other site 1232383000783 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1232383000784 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232383000785 dimer interface [polypeptide binding]; other site 1232383000786 conserved gate region; other site 1232383000787 putative PBP binding loops; other site 1232383000788 ABC-ATPase subunit interface; other site 1232383000789 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1232383000790 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1232383000791 Ubiquitin-like proteins; Region: UBQ; cl00155 1232383000792 charged pocket; other site 1232383000793 hydrophobic patch; other site 1232383000794 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1232383000795 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1232383000796 Walker A/P-loop; other site 1232383000797 ATP binding site [chemical binding]; other site 1232383000798 Q-loop/lid; other site 1232383000799 ABC transporter signature motif; other site 1232383000800 Walker B; other site 1232383000801 D-loop; other site 1232383000802 H-loop/switch region; other site 1232383000803 Predicted membrane protein [Function unknown]; Region: COG1950 1232383000804 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1232383000805 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1232383000806 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232383000807 homodimer interface [polypeptide binding]; other site 1232383000808 catalytic residue [active] 1232383000809 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1232383000810 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1232383000811 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1232383000812 Divalent cation transporter; Region: MgtE; cl00786 1232383000813 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1232383000814 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1232383000815 transmembrane helices; other site 1232383000816 prephenate dehydrogenase; Validated; Region: PRK06545 1232383000817 prephenate dehydrogenase; Validated; Region: PRK08507 1232383000818 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1232383000819 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1232383000820 nucleoside/Zn binding site; other site 1232383000821 dimer interface [polypeptide binding]; other site 1232383000822 catalytic motif [active] 1232383000823 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 1232383000824 MMPL family; Region: MMPL; pfam03176 1232383000825 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1232383000826 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1232383000827 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1232383000828 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1232383000829 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1232383000830 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232383000831 Q-loop/lid; other site 1232383000832 ABC transporter signature motif; other site 1232383000833 Walker B; other site 1232383000834 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1232383000835 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 1232383000836 active site 1232383000837 HIGH motif; other site 1232383000838 nucleotide binding site [chemical binding]; other site 1232383000839 active site 1232383000840 KMSKS motif; other site 1232383000841 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 1232383000842 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 1232383000843 putative active site [active] 1232383000844 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1232383000845 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1232383000846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232383000847 homodimer interface [polypeptide binding]; other site 1232383000848 catalytic residue [active] 1232383000849 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1232383000850 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1232383000851 hypothetical protein; Validated; Region: PRK00153 1232383000852 recombination protein RecR; Reviewed; Region: recR; PRK00076 1232383000853 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 1232383000854 RecR protein; Region: RecR; pfam02132 1232383000855 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1232383000856 putative active site [active] 1232383000857 putative metal-binding site [ion binding]; other site 1232383000858 tetramer interface [polypeptide binding]; other site 1232383000859 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232383000860 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1232383000861 acyl-activating enzyme (AAE) consensus motif; other site 1232383000862 AMP binding site [chemical binding]; other site 1232383000863 active site 1232383000864 CoA binding site [chemical binding]; other site 1232383000865 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232383000866 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 1232383000867 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1232383000868 putative trimer interface [polypeptide binding]; other site 1232383000869 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1232383000870 putative CoA binding site [chemical binding]; other site 1232383000871 putative CoA binding site [chemical binding]; other site 1232383000872 putative trimer interface [polypeptide binding]; other site 1232383000873 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1232383000874 putative trimer interface [polypeptide binding]; other site 1232383000875 putative CoA binding site [chemical binding]; other site 1232383000876 Predicted membrane protein [Function unknown]; Region: COG2311 1232383000877 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1232383000878 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1232383000879 catalytic triad [active] 1232383000880 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1232383000881 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1232383000882 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1232383000883 DNA polymerase III subunit epsilon; Validated; Region: PRK05601 1232383000884 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1232383000885 active site 1232383000886 substrate binding site [chemical binding]; other site 1232383000887 2-isopropylmalate synthase; Validated; Region: PRK03739 1232383000888 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1232383000889 active site 1232383000890 catalytic residues [active] 1232383000891 metal binding site [ion binding]; metal-binding site 1232383000892 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1232383000893 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232383000894 aspartate kinase; Reviewed; Region: PRK06635 1232383000895 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1232383000896 putative nucleotide binding site [chemical binding]; other site 1232383000897 putative catalytic residues [active] 1232383000898 putative Mg ion binding site [ion binding]; other site 1232383000899 putative aspartate binding site [chemical binding]; other site 1232383000900 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1232383000901 putative allosteric regulatory site; other site 1232383000902 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1232383000903 putative allosteric regulatory residue; other site 1232383000904 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1232383000905 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1232383000906 RNA polymerase sigma factor; Provisional; Region: PRK12535 1232383000907 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1232383000908 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1232383000909 DNA binding residues [nucleotide binding] 1232383000910 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1232383000911 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1232383000912 heme binding pocket [chemical binding]; other site 1232383000913 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1232383000914 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1232383000915 AsnC family; Region: AsnC_trans_reg; pfam01037 1232383000916 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1232383000917 Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687 1232383000918 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1232383000919 dimerization interface [polypeptide binding]; other site 1232383000920 putative DNA binding site [nucleotide binding]; other site 1232383000921 putative Zn2+ binding site [ion binding]; other site 1232383000922 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1232383000923 arsenical-resistance protein; Region: acr3; TIGR00832 1232383000924 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1232383000925 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1232383000926 active site 1232383000927 Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism]; Region: MnhG; COG1320 1232383000928 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612 1232383000929 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654 1232383000930 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 1232383000931 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1232383000932 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 1232383000933 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 1232383000934 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1232383000935 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244 1232383000936 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1232383000937 Predicted membrane protein [Function unknown]; Region: COG1511 1232383000938 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 1232383000939 Malonate transporter MadL subunit; Region: MadL; cl04273 1232383000940 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1232383000941 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1232383000942 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1232383000943 dimerization interface [polypeptide binding]; other site 1232383000944 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1232383000945 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 1232383000946 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 1232383000947 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293; cl07913 1232383000948 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 1232383000949 malonate decarboxylase acyl carrier protein; Region: malonate_delta; TIGR03130 1232383000950 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 1232383000951 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874 1232383000952 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 1232383000953 Coenzyme A transferase; Region: CoA_trans; cl17247 1232383000954 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1232383000955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1232383000956 active site 1232383000957 phosphorylation site [posttranslational modification] 1232383000958 intermolecular recognition site; other site 1232383000959 dimerization interface [polypeptide binding]; other site 1232383000960 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1232383000961 DNA binding site [nucleotide binding] 1232383000962 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1232383000963 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1232383000964 dimerization interface [polypeptide binding]; other site 1232383000965 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1232383000966 dimer interface [polypeptide binding]; other site 1232383000967 phosphorylation site [posttranslational modification] 1232383000968 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232383000969 ATP binding site [chemical binding]; other site 1232383000970 Mg2+ binding site [ion binding]; other site 1232383000971 G-X-G motif; other site 1232383000972 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1232383000973 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1232383000974 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1232383000975 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1232383000976 putative active site [active] 1232383000977 putative metal binding site [ion binding]; other site 1232383000978 Yqey-like protein; Region: YqeY; pfam09424 1232383000979 Transglycosylase; Region: Transgly; pfam00912 1232383000980 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1232383000981 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1232383000982 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1232383000983 Transcription factor WhiB; Region: Whib; pfam02467 1232383000984 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1232383000985 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1232383000986 homotrimer interaction site [polypeptide binding]; other site 1232383000987 putative active site [active] 1232383000988 metabolite-proton symporter; Region: 2A0106; TIGR00883 1232383000989 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383000990 putative substrate translocation pore; other site 1232383000991 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1232383000992 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232383000993 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1232383000994 acyl-activating enzyme (AAE) consensus motif; other site 1232383000995 acyl-activating enzyme (AAE) consensus motif; other site 1232383000996 putative AMP binding site [chemical binding]; other site 1232383000997 putative active site [active] 1232383000998 putative CoA binding site [chemical binding]; other site 1232383000999 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1232383001000 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1232383001001 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1232383001002 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232383001003 NAD(P) binding site [chemical binding]; other site 1232383001004 active site 1232383001005 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1232383001006 active site 1232383001007 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232383001008 acyl-coenzyme A oxidase; Region: PLN02526 1232383001009 active site 1232383001010 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1232383001011 putative active site [active] 1232383001012 putative catalytic site [active] 1232383001013 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1232383001014 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1232383001015 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1232383001016 ligand binding site [chemical binding]; other site 1232383001017 flexible hinge region; other site 1232383001018 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1232383001019 putative switch regulator; other site 1232383001020 non-specific DNA interactions [nucleotide binding]; other site 1232383001021 DNA binding site [nucleotide binding] 1232383001022 sequence specific DNA binding site [nucleotide binding]; other site 1232383001023 putative cAMP binding site [chemical binding]; other site 1232383001024 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1232383001025 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1232383001026 minor groove reading motif; other site 1232383001027 helix-hairpin-helix signature motif; other site 1232383001028 substrate binding pocket [chemical binding]; other site 1232383001029 active site 1232383001030 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1232383001031 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1232383001032 catalytic residues [active] 1232383001033 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1232383001034 putative active site [active] 1232383001035 putative CoA binding site [chemical binding]; other site 1232383001036 nudix motif; other site 1232383001037 metal binding site [ion binding]; metal-binding site 1232383001038 Colicin V production protein; Region: Colicin_V; pfam02674 1232383001039 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1232383001040 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1232383001041 active site 1232383001042 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1232383001043 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1232383001044 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1232383001045 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1232383001046 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232383001047 motif II; other site 1232383001048 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1232383001049 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1232383001050 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1232383001051 ATP binding site [chemical binding]; other site 1232383001052 Walker A motif; other site 1232383001053 hexamer interface [polypeptide binding]; other site 1232383001054 Walker B motif; other site 1232383001055 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1232383001056 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1232383001057 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 1232383001058 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1232383001059 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1232383001060 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1232383001061 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1232383001062 ATP binding site [chemical binding]; other site 1232383001063 putative Mg++ binding site [ion binding]; other site 1232383001064 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1232383001065 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1232383001066 DNA-binding site [nucleotide binding]; DNA binding site 1232383001067 RNA-binding motif; other site 1232383001068 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1232383001069 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1232383001070 active site 1232383001071 interdomain interaction site; other site 1232383001072 putative metal-binding site [ion binding]; other site 1232383001073 nucleotide binding site [chemical binding]; other site 1232383001074 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1232383001075 domain I; other site 1232383001076 DNA binding groove [nucleotide binding] 1232383001077 phosphate binding site [ion binding]; other site 1232383001078 domain II; other site 1232383001079 domain III; other site 1232383001080 nucleotide binding site [chemical binding]; other site 1232383001081 catalytic site [active] 1232383001082 domain IV; other site 1232383001083 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1232383001084 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1232383001085 YhhN-like protein; Region: YhhN; pfam07947 1232383001086 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1232383001087 dimerization interface [polypeptide binding]; other site 1232383001088 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1232383001089 cyclase homology domain; Region: CHD; cd07302 1232383001090 nucleotidyl binding site; other site 1232383001091 metal binding site [ion binding]; metal-binding site 1232383001092 dimer interface [polypeptide binding]; other site 1232383001093 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1232383001094 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1232383001095 Walker A motif; other site 1232383001096 ATP binding site [chemical binding]; other site 1232383001097 Walker B motif; other site 1232383001098 arginine finger; other site 1232383001099 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 1232383001100 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 1232383001101 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 1232383001102 active site 1232383001103 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1232383001104 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1232383001105 RNA binding surface [nucleotide binding]; other site 1232383001106 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1232383001107 active site 1232383001108 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1232383001109 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1232383001110 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1232383001111 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1232383001112 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1232383001113 NAD binding site [chemical binding]; other site 1232383001114 catalytic Zn binding site [ion binding]; other site 1232383001115 substrate binding site [chemical binding]; other site 1232383001116 structural Zn binding site [ion binding]; other site 1232383001117 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1232383001118 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1232383001119 classical (c) SDRs; Region: SDR_c; cd05233 1232383001120 NAD(P) binding site [chemical binding]; other site 1232383001121 active site 1232383001122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383001123 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1232383001124 putative substrate translocation pore; other site 1232383001125 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1232383001126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232383001127 NAD(P) binding site [chemical binding]; other site 1232383001128 active site 1232383001129 hypothetical protein; Validated; Region: PRK09039 1232383001130 Integrase core domain; Region: rve; pfam00665 1232383001131 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 1232383001132 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1232383001133 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1232383001134 Ligand binding site; other site 1232383001135 Putative Catalytic site; other site 1232383001136 DXD motif; other site 1232383001137 Ribonuclease HI [DNA replication, recombination, and repair]; Region: RnhA; COG0328 1232383001138 RNA/DNA hybrid binding site [nucleotide binding]; other site 1232383001139 active site 1232383001140 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1232383001141 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1232383001142 Probable Catalytic site; other site 1232383001143 metal-binding site 1232383001144 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1232383001145 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1232383001146 putative active site [active] 1232383001147 putative metal binding site [ion binding]; other site 1232383001148 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1232383001149 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1232383001150 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1232383001151 putative NAD(P) binding site [chemical binding]; other site 1232383001152 putative substrate binding site [chemical binding]; other site 1232383001153 catalytic Zn binding site [ion binding]; other site 1232383001154 structural Zn binding site [ion binding]; other site 1232383001155 dimer interface [polypeptide binding]; other site 1232383001156 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1232383001157 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1232383001158 substrate binding site; other site 1232383001159 tetramer interface; other site 1232383001160 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1232383001161 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 1232383001162 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1232383001163 NADP binding site [chemical binding]; other site 1232383001164 active site 1232383001165 putative substrate binding site [chemical binding]; other site 1232383001166 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1232383001167 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1232383001168 NAD binding site [chemical binding]; other site 1232383001169 substrate binding site [chemical binding]; other site 1232383001170 homodimer interface [polypeptide binding]; other site 1232383001171 active site 1232383001172 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370 1232383001173 dimer interface [polypeptide binding]; other site 1232383001174 FMN binding site [chemical binding]; other site 1232383001175 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1232383001176 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1232383001177 siderophore binding site; other site 1232383001178 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 1232383001179 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 1232383001180 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1232383001181 Zn binding site [ion binding]; other site 1232383001182 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1232383001183 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1232383001184 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1232383001185 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1232383001186 Putative esterase; Region: Esterase; pfam00756 1232383001187 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1232383001188 Chain length determinant protein; Region: Wzz; cl15801 1232383001189 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1232383001190 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1232383001191 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1232383001192 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1232383001193 active site 1232383001194 VPS10 domain; Region: VPS10; smart00602 1232383001195 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1232383001196 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1232383001197 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1232383001198 NAD(P) binding site [chemical binding]; other site 1232383001199 homodimer interface [polypeptide binding]; other site 1232383001200 substrate binding site [chemical binding]; other site 1232383001201 active site 1232383001202 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1232383001203 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1232383001204 inhibitor-cofactor binding pocket; inhibition site 1232383001205 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232383001206 catalytic residue [active] 1232383001207 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1232383001208 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1232383001209 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1232383001210 putative trimer interface [polypeptide binding]; other site 1232383001211 putative CoA binding site [chemical binding]; other site 1232383001212 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1232383001213 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1232383001214 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1232383001215 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1232383001216 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1232383001217 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1232383001218 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1232383001219 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1232383001220 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1232383001221 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232383001222 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1232383001223 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1232383001224 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1232383001225 active site 1232383001226 tetramer interface; other site 1232383001227 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1232383001228 putative deacylase active site [active] 1232383001229 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1232383001230 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1232383001231 non-specific DNA binding site [nucleotide binding]; other site 1232383001232 salt bridge; other site 1232383001233 sequence-specific DNA binding site [nucleotide binding]; other site 1232383001234 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1232383001235 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1232383001236 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1232383001237 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 1232383001238 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1232383001239 putative Iron-sulfur protein interface [polypeptide binding]; other site 1232383001240 proximal heme binding site [chemical binding]; other site 1232383001241 distal heme binding site [chemical binding]; other site 1232383001242 putative dimer interface [polypeptide binding]; other site 1232383001243 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 1232383001244 L-aspartate oxidase; Provisional; Region: PRK06175 1232383001245 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1232383001246 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 1232383001247 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1232383001248 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1232383001249 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1232383001250 Predicted membrane protein [Function unknown]; Region: COG2733 1232383001251 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1232383001252 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232383001253 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1232383001254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383001255 putative substrate translocation pore; other site 1232383001256 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383001257 putative substrate translocation pore; other site 1232383001258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383001259 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1232383001260 putative substrate translocation pore; other site 1232383001261 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1232383001262 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1232383001263 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1232383001264 putative active site [active] 1232383001265 putative substrate binding site [chemical binding]; other site 1232383001266 putative cosubstrate binding site; other site 1232383001267 catalytic site [active] 1232383001268 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1232383001269 intersubunit interface [polypeptide binding]; other site 1232383001270 active site 1232383001271 catalytic residue [active] 1232383001272 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1232383001273 putative homodimer interface [polypeptide binding]; other site 1232383001274 putative homotetramer interface [polypeptide binding]; other site 1232383001275 putative allosteric switch controlling residues; other site 1232383001276 putative metal binding site [ion binding]; other site 1232383001277 putative homodimer-homodimer interface [polypeptide binding]; other site 1232383001278 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1232383001279 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1232383001280 metal-binding site [ion binding] 1232383001281 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1232383001282 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1232383001283 Intracellular septation protein A; Region: IspA; cl01098 1232383001284 Htaa; Region: HtaA; pfam04213 1232383001285 Htaa; Region: HtaA; pfam04213 1232383001286 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 1232383001287 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1232383001288 intersubunit interface [polypeptide binding]; other site 1232383001289 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1232383001290 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1232383001291 dimer interface [polypeptide binding]; other site 1232383001292 putative PBP binding regions; other site 1232383001293 ABC-ATPase subunit interface; other site 1232383001294 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 1232383001295 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1232383001296 Walker A/P-loop; other site 1232383001297 ATP binding site [chemical binding]; other site 1232383001298 Q-loop/lid; other site 1232383001299 ABC transporter signature motif; other site 1232383001300 Walker B; other site 1232383001301 D-loop; other site 1232383001302 H-loop/switch region; other site 1232383001303 Htaa; Region: HtaA; pfam04213 1232383001304 Htaa; Region: HtaA; pfam04213 1232383001305 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1232383001306 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1232383001307 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1232383001308 FAD binding domain; Region: FAD_binding_4; pfam01565 1232383001309 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1232383001310 hypothetical protein; Provisional; Region: PRK07758 1232383001311 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1232383001312 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 1232383001313 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232383001314 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232383001315 acyl-activating enzyme (AAE) consensus motif; other site 1232383001316 AMP binding site [chemical binding]; other site 1232383001317 active site 1232383001318 CoA binding site [chemical binding]; other site 1232383001319 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1232383001320 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1232383001321 putative ADP-binding pocket [chemical binding]; other site 1232383001322 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1232383001323 catalytic core [active] 1232383001324 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1232383001325 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1232383001326 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1232383001327 dimer interface [polypeptide binding]; other site 1232383001328 phosphorylation site [posttranslational modification] 1232383001329 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232383001330 ATP binding site [chemical binding]; other site 1232383001331 Mg2+ binding site [ion binding]; other site 1232383001332 G-X-G motif; other site 1232383001333 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1232383001334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1232383001335 active site 1232383001336 phosphorylation site [posttranslational modification] 1232383001337 intermolecular recognition site; other site 1232383001338 dimerization interface [polypeptide binding]; other site 1232383001339 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1232383001340 DNA binding site [nucleotide binding] 1232383001341 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1232383001342 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1232383001343 FtsX-like permease family; Region: FtsX; pfam02687 1232383001344 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1232383001345 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1232383001346 FtsX-like permease family; Region: FtsX; pfam02687 1232383001347 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1232383001348 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1232383001349 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1232383001350 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1232383001351 DNA binding domain, excisionase family; Region: excise; TIGR01764 1232383001352 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1232383001353 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 1232383001354 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1232383001355 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1232383001356 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1232383001357 tRNA; other site 1232383001358 putative tRNA binding site [nucleotide binding]; other site 1232383001359 putative NADP binding site [chemical binding]; other site 1232383001360 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1232383001361 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1232383001362 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1232383001363 domain interfaces; other site 1232383001364 active site 1232383001365 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1232383001366 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1232383001367 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1232383001368 dimerization interface [polypeptide binding]; other site 1232383001369 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383001370 metabolite-proton symporter; Region: 2A0106; TIGR00883 1232383001371 putative substrate translocation pore; other site 1232383001372 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1232383001373 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1232383001374 AP (apurinic/apyrimidinic) site pocket; other site 1232383001375 DNA interaction; other site 1232383001376 Metal-binding active site; metal-binding site 1232383001377 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 1232383001378 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1232383001379 active site 1232383001380 metal binding site [ion binding]; metal-binding site 1232383001381 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1232383001382 active site 1232383001383 Fe binding site [ion binding]; other site 1232383001384 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1232383001385 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1232383001386 active site 1232383001387 trimer interface [polypeptide binding]; other site 1232383001388 dimer interface [polypeptide binding]; other site 1232383001389 quinate/shikimate dehydrogenase; Provisional; Region: PRK14027 1232383001390 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1232383001391 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1232383001392 shikimate binding site; other site 1232383001393 NAD(P) binding site [chemical binding]; other site 1232383001394 Ribosomal protein L7/L12 [Translation, ribosomal structure and biogenesis]; Region: RplL; COG0222 1232383001395 L11 interface [polypeptide binding]; other site 1232383001396 putative EF-Tu interaction site [polypeptide binding]; other site 1232383001397 putative EF-G interaction site [polypeptide binding]; other site 1232383001398 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1232383001399 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1232383001400 Walker A/P-loop; other site 1232383001401 ATP binding site [chemical binding]; other site 1232383001402 Q-loop/lid; other site 1232383001403 ABC transporter signature motif; other site 1232383001404 Walker B; other site 1232383001405 D-loop; other site 1232383001406 H-loop/switch region; other site 1232383001407 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1232383001408 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232383001409 dimer interface [polypeptide binding]; other site 1232383001410 conserved gate region; other site 1232383001411 putative PBP binding loops; other site 1232383001412 ABC-ATPase subunit interface; other site 1232383001413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1232383001414 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1232383001415 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1232383001416 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1232383001417 active site 1232383001418 homodimer interface [polypeptide binding]; other site 1232383001419 SAM binding site [chemical binding]; other site 1232383001420 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1232383001421 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1232383001422 active site 1232383001423 Domain of unknown function (DUF3806); Region: DUF3806; pfam12713 1232383001424 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1232383001425 dimer interface [polypeptide binding]; other site 1232383001426 active site 1232383001427 Schiff base residues; other site 1232383001428 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1232383001429 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1232383001430 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1232383001431 substrate binding site [chemical binding]; other site 1232383001432 active site 1232383001433 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1232383001434 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1232383001435 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1232383001436 inhibitor-cofactor binding pocket; inhibition site 1232383001437 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232383001438 catalytic residue [active] 1232383001439 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1232383001440 catalytic core [active] 1232383001441 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1232383001442 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1232383001443 catalytic residues [active] 1232383001444 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1232383001445 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1232383001446 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1232383001447 ResB-like family; Region: ResB; pfam05140 1232383001448 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1232383001449 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1232383001450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232383001451 dimer interface [polypeptide binding]; other site 1232383001452 conserved gate region; other site 1232383001453 putative PBP binding loops; other site 1232383001454 ABC-ATPase subunit interface; other site 1232383001455 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1232383001456 NMT1/THI5 like; Region: NMT1; pfam09084 1232383001457 ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005 1232383001458 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1232383001459 Walker A/P-loop; other site 1232383001460 ATP binding site [chemical binding]; other site 1232383001461 Q-loop/lid; other site 1232383001462 ABC transporter signature motif; other site 1232383001463 Walker B; other site 1232383001464 D-loop; other site 1232383001465 H-loop/switch region; other site 1232383001466 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1232383001467 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1232383001468 active site 1232383001469 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1232383001470 homotrimer interaction site [polypeptide binding]; other site 1232383001471 putative active site [active] 1232383001472 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1232383001473 putative DNA binding site [nucleotide binding]; other site 1232383001474 dimerization interface [polypeptide binding]; other site 1232383001475 putative Zn2+ binding site [ion binding]; other site 1232383001476 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 1232383001477 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1232383001478 UbiA prenyltransferase family; Region: UbiA; pfam01040 1232383001479 acetolactate synthase catalytic subunit; Validated; Region: PRK08327 1232383001480 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1232383001481 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232383001482 acyl-activating enzyme (AAE) consensus motif; other site 1232383001483 AMP binding site [chemical binding]; other site 1232383001484 active site 1232383001485 CoA binding site [chemical binding]; other site 1232383001486 Predicted membrane protein [Function unknown]; Region: COG2259 1232383001487 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1232383001488 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1232383001489 dimer interface [polypeptide binding]; other site 1232383001490 NADP binding site [chemical binding]; other site 1232383001491 catalytic residues [active] 1232383001492 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 1232383001493 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1232383001494 putative active site [active] 1232383001495 catalytic residue [active] 1232383001496 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1232383001497 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1232383001498 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447 1232383001499 putative dimerization interface [polypeptide binding]; other site 1232383001500 putative substrate binding pocket [chemical binding]; other site 1232383001501 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1232383001502 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1232383001503 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1232383001504 active site 1232383001505 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1232383001506 active site 1 [active] 1232383001507 active site 2 [active] 1232383001508 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232383001509 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232383001510 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1232383001511 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1232383001512 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1232383001513 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 1232383001514 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1232383001515 Protein of unknown function DUF262; Region: DUF262; pfam03235 1232383001516 Protein of unknown function DUF262; Region: DUF262; pfam03235 1232383001517 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1232383001518 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1232383001519 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232383001520 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232383001521 Protein of unknown function (DUF2872); Region: DUF2872; pfam11071 1232383001522 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1232383001523 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1232383001524 dimerization interface [polypeptide binding]; other site 1232383001525 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1232383001526 dimer interface [polypeptide binding]; other site 1232383001527 phosphorylation site [posttranslational modification] 1232383001528 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232383001529 ATP binding site [chemical binding]; other site 1232383001530 Mg2+ binding site [ion binding]; other site 1232383001531 G-X-G motif; other site 1232383001532 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1232383001533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1232383001534 active site 1232383001535 phosphorylation site [posttranslational modification] 1232383001536 intermolecular recognition site; other site 1232383001537 dimerization interface [polypeptide binding]; other site 1232383001538 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1232383001539 DNA binding site [nucleotide binding] 1232383001540 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 1232383001541 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1232383001542 active site 1232383001543 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1232383001544 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1232383001545 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1232383001546 AAA domain; Region: AAA_23; pfam13476 1232383001547 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232383001548 Walker A/P-loop; other site 1232383001549 ATP binding site [chemical binding]; other site 1232383001550 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1232383001551 putative active site [active] 1232383001552 putative metal-binding site [ion binding]; other site 1232383001553 AAA domain; Region: AAA_30; pfam13604 1232383001554 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1232383001555 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1232383001556 Integrase core domain; Region: rve; pfam00665 1232383001557 Replicase family; Region: Replicase; pfam03090 1232383001558 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1232383001559 Integrase core domain; Region: rve; pfam00665 1232383001560 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1232383001561 LGFP repeat; Region: LGFP; pfam08310 1232383001562 LGFP repeat; Region: LGFP; pfam08310 1232383001563 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1232383001564 Integrase core domain; Region: rve; pfam00665 1232383001565 Resolvase, N terminal domain; Region: Resolvase; pfam00239 1232383001566 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1232383001567 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1232383001568 DNA-binding interface [nucleotide binding]; DNA binding site 1232383001569 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1232383001570 Predicted membrane protein [Function unknown]; Region: COG4325 1232383001571 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 1232383001572 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232383001573 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1232383001574 substrate binding site [chemical binding]; other site 1232383001575 oxyanion hole (OAH) forming residues; other site 1232383001576 trimer interface [polypeptide binding]; other site 1232383001577 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1232383001578 aromatic arch; other site 1232383001579 DCoH dimer interaction site [polypeptide binding]; other site 1232383001580 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1232383001581 DCoH tetramer interaction site [polypeptide binding]; other site 1232383001582 substrate binding site [chemical binding]; other site 1232383001583 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 1232383001584 catalytic triad [active] 1232383001585 active site nucleophile [active] 1232383001586 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1232383001587 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1232383001588 active site 1232383001589 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 1232383001590 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1232383001591 dimer interface [polypeptide binding]; other site 1232383001592 tetramer interface [polypeptide binding]; other site 1232383001593 PYR/PP interface [polypeptide binding]; other site 1232383001594 TPP binding site [chemical binding]; other site 1232383001595 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1232383001596 TPP-binding site; other site 1232383001597 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1232383001598 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1232383001599 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1232383001600 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1232383001601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232383001602 S-adenosylmethionine binding site [chemical binding]; other site 1232383001603 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1232383001604 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1232383001605 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1232383001606 substrate binding pocket [chemical binding]; other site 1232383001607 chain length determination region; other site 1232383001608 substrate-Mg2+ binding site; other site 1232383001609 catalytic residues [active] 1232383001610 aspartate-rich region 1; other site 1232383001611 active site lid residues [active] 1232383001612 aspartate-rich region 2; other site 1232383001613 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1232383001614 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1232383001615 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1232383001616 putative homodimer interface [polypeptide binding]; other site 1232383001617 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1232383001618 heterodimer interface [polypeptide binding]; other site 1232383001619 homodimer interface [polypeptide binding]; other site 1232383001620 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1232383001621 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1232383001622 23S rRNA interface [nucleotide binding]; other site 1232383001623 L7/L12 interface [polypeptide binding]; other site 1232383001624 putative thiostrepton binding site; other site 1232383001625 L25 interface [polypeptide binding]; other site 1232383001626 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1232383001627 mRNA/rRNA interface [nucleotide binding]; other site 1232383001628 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1232383001629 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1232383001630 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 1232383001631 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1232383001632 inhibitor-cofactor binding pocket; inhibition site 1232383001633 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232383001634 catalytic residue [active] 1232383001635 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1232383001636 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1232383001637 tetramerization interface [polypeptide binding]; other site 1232383001638 NAD(P) binding site [chemical binding]; other site 1232383001639 catalytic residues [active] 1232383001640 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1232383001641 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1232383001642 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1232383001643 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1232383001644 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1232383001645 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1232383001646 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1232383001647 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1232383001648 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1232383001649 23S rRNA interface [nucleotide binding]; other site 1232383001650 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1232383001651 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1232383001652 core dimer interface [polypeptide binding]; other site 1232383001653 peripheral dimer interface [polypeptide binding]; other site 1232383001654 L10 interface [polypeptide binding]; other site 1232383001655 L11 interface [polypeptide binding]; other site 1232383001656 putative EF-Tu interaction site [polypeptide binding]; other site 1232383001657 putative EF-G interaction site [polypeptide binding]; other site 1232383001658 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1232383001659 Tetraspanin family; Region: Tetraspannin; pfam00335 1232383001660 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1232383001661 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1232383001662 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1232383001663 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1232383001664 RPB1 interaction site [polypeptide binding]; other site 1232383001665 RPB10 interaction site [polypeptide binding]; other site 1232383001666 RPB11 interaction site [polypeptide binding]; other site 1232383001667 RPB3 interaction site [polypeptide binding]; other site 1232383001668 RPB12 interaction site [polypeptide binding]; other site 1232383001669 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1232383001670 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1232383001671 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1232383001672 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1232383001673 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1232383001674 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1232383001675 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1232383001676 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1232383001677 G-loop; other site 1232383001678 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1232383001679 DNA binding site [nucleotide binding] 1232383001680 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1232383001681 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1232383001682 salt bridge; other site 1232383001683 non-specific DNA binding site [nucleotide binding]; other site 1232383001684 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1232383001685 sequence-specific DNA binding site [nucleotide binding]; other site 1232383001686 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1232383001687 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1232383001688 S17 interaction site [polypeptide binding]; other site 1232383001689 S8 interaction site; other site 1232383001690 16S rRNA interaction site [nucleotide binding]; other site 1232383001691 streptomycin interaction site [chemical binding]; other site 1232383001692 23S rRNA interaction site [nucleotide binding]; other site 1232383001693 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1232383001694 30S ribosomal protein S7; Validated; Region: PRK05302 1232383001695 elongation factor G; Reviewed; Region: PRK00007 1232383001696 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1232383001697 G1 box; other site 1232383001698 putative GEF interaction site [polypeptide binding]; other site 1232383001699 GTP/Mg2+ binding site [chemical binding]; other site 1232383001700 Switch I region; other site 1232383001701 G2 box; other site 1232383001702 G3 box; other site 1232383001703 Switch II region; other site 1232383001704 G4 box; other site 1232383001705 G5 box; other site 1232383001706 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1232383001707 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1232383001708 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1232383001709 elongation factor Tu; Reviewed; Region: PRK00049 1232383001710 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1232383001711 G1 box; other site 1232383001712 GEF interaction site [polypeptide binding]; other site 1232383001713 GTP/Mg2+ binding site [chemical binding]; other site 1232383001714 Switch I region; other site 1232383001715 G2 box; other site 1232383001716 G3 box; other site 1232383001717 Switch II region; other site 1232383001718 G4 box; other site 1232383001719 G5 box; other site 1232383001720 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1232383001721 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1232383001722 Antibiotic Binding Site [chemical binding]; other site 1232383001723 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1232383001724 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1232383001725 Walker A/P-loop; other site 1232383001726 ATP binding site [chemical binding]; other site 1232383001727 Q-loop/lid; other site 1232383001728 ABC transporter signature motif; other site 1232383001729 Walker B; other site 1232383001730 D-loop; other site 1232383001731 H-loop/switch region; other site 1232383001732 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1232383001733 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1232383001734 ABC-ATPase subunit interface; other site 1232383001735 dimer interface [polypeptide binding]; other site 1232383001736 putative PBP binding regions; other site 1232383001737 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1232383001738 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1232383001739 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1232383001740 ABC-ATPase subunit interface; other site 1232383001741 dimer interface [polypeptide binding]; other site 1232383001742 putative PBP binding regions; other site 1232383001743 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1232383001744 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1232383001745 conserved cys residue [active] 1232383001746 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1232383001747 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1232383001748 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1232383001749 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1232383001750 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1232383001751 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1232383001752 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1232383001753 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1232383001754 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1232383001755 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1232383001756 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1232383001757 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1232383001758 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1232383001759 putative translocon binding site; other site 1232383001760 protein-rRNA interface [nucleotide binding]; other site 1232383001761 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1232383001762 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1232383001763 G-X-X-G motif; other site 1232383001764 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1232383001765 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1232383001766 23S rRNA interface [nucleotide binding]; other site 1232383001767 5S rRNA interface [nucleotide binding]; other site 1232383001768 putative antibiotic binding site [chemical binding]; other site 1232383001769 L25 interface [polypeptide binding]; other site 1232383001770 L27 interface [polypeptide binding]; other site 1232383001771 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1232383001772 putative translocon interaction site; other site 1232383001773 23S rRNA interface [nucleotide binding]; other site 1232383001774 signal recognition particle (SRP54) interaction site; other site 1232383001775 L23 interface [polypeptide binding]; other site 1232383001776 trigger factor interaction site; other site 1232383001777 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1232383001778 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1232383001779 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1232383001780 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1232383001781 RNA binding site [nucleotide binding]; other site 1232383001782 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1232383001783 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1232383001784 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1232383001785 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1232383001786 active site 1232383001787 catalytic triad [active] 1232383001788 oxyanion hole [active] 1232383001789 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1232383001790 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1232383001791 active site 1232383001792 catalytic tetrad [active] 1232383001793 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1232383001794 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1232383001795 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1232383001796 putative molybdopterin cofactor binding site [chemical binding]; other site 1232383001797 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1232383001798 putative molybdopterin cofactor binding site; other site 1232383001799 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1232383001800 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1232383001801 Walker A/P-loop; other site 1232383001802 ATP binding site [chemical binding]; other site 1232383001803 Q-loop/lid; other site 1232383001804 ABC transporter signature motif; other site 1232383001805 Walker B; other site 1232383001806 D-loop; other site 1232383001807 H-loop/switch region; other site 1232383001808 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1232383001809 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232383001810 Walker A/P-loop; other site 1232383001811 ATP binding site [chemical binding]; other site 1232383001812 Q-loop/lid; other site 1232383001813 ABC transporter signature motif; other site 1232383001814 Walker B; other site 1232383001815 D-loop; other site 1232383001816 H-loop/switch region; other site 1232383001817 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1232383001818 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1232383001819 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1232383001820 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1232383001821 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1232383001822 Coenzyme A binding pocket [chemical binding]; other site 1232383001823 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1232383001824 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1232383001825 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1232383001826 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1232383001827 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1232383001828 5S rRNA interface [nucleotide binding]; other site 1232383001829 L27 interface [polypeptide binding]; other site 1232383001830 23S rRNA interface [nucleotide binding]; other site 1232383001831 L5 interface [polypeptide binding]; other site 1232383001832 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1232383001833 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1232383001834 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1232383001835 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1232383001836 23S rRNA binding site [nucleotide binding]; other site 1232383001837 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1232383001838 metabolite-proton symporter; Region: 2A0106; TIGR00883 1232383001839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383001840 putative substrate translocation pore; other site 1232383001841 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232383001842 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1232383001843 acyl-activating enzyme (AAE) consensus motif; other site 1232383001844 AMP binding site [chemical binding]; other site 1232383001845 active site 1232383001846 CoA binding site [chemical binding]; other site 1232383001847 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232383001848 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232383001849 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1232383001850 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1232383001851 CoenzymeA binding site [chemical binding]; other site 1232383001852 subunit interaction site [polypeptide binding]; other site 1232383001853 PHB binding site; other site 1232383001854 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 1232383001855 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 1232383001856 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 1232383001857 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 1232383001858 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1232383001859 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 1232383001860 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1232383001861 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1232383001862 FAD binding pocket [chemical binding]; other site 1232383001863 FAD binding motif [chemical binding]; other site 1232383001864 phosphate binding motif [ion binding]; other site 1232383001865 beta-alpha-beta structure motif; other site 1232383001866 NAD(p) ribose binding residues [chemical binding]; other site 1232383001867 NAD binding pocket [chemical binding]; other site 1232383001868 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1232383001869 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1232383001870 catalytic loop [active] 1232383001871 iron binding site [ion binding]; other site 1232383001872 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1232383001873 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232383001874 substrate binding site [chemical binding]; other site 1232383001875 oxyanion hole (OAH) forming residues; other site 1232383001876 trimer interface [polypeptide binding]; other site 1232383001877 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1232383001878 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1232383001879 dimer interface [polypeptide binding]; other site 1232383001880 active site 1232383001881 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232383001882 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1232383001883 substrate binding site [chemical binding]; other site 1232383001884 oxyanion hole (OAH) forming residues; other site 1232383001885 trimer interface [polypeptide binding]; other site 1232383001886 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1232383001887 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1232383001888 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1232383001889 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1232383001890 CoenzymeA binding site [chemical binding]; other site 1232383001891 subunit interaction site [polypeptide binding]; other site 1232383001892 PHB binding site; other site 1232383001893 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 1232383001894 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 1232383001895 substrate binding site [chemical binding]; other site 1232383001896 dimer interface [polypeptide binding]; other site 1232383001897 NADP binding site [chemical binding]; other site 1232383001898 catalytic residues [active] 1232383001899 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1232383001900 active site 2 [active] 1232383001901 active site 1 [active] 1232383001902 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1232383001903 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1232383001904 NAD binding site [chemical binding]; other site 1232383001905 catalytic residues [active] 1232383001906 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1232383001907 Zn2+ binding site [ion binding]; other site 1232383001908 Mg2+ binding site [ion binding]; other site 1232383001909 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1232383001910 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1232383001911 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232383001912 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1232383001913 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1232383001914 catalytic loop [active] 1232383001915 iron binding site [ion binding]; other site 1232383001916 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1232383001917 classical (c) SDRs; Region: SDR_c; cd05233 1232383001918 NAD(P) binding site [chemical binding]; other site 1232383001919 active site 1232383001920 hypothetical protein; Provisional; Region: PRK08296 1232383001921 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1232383001922 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1232383001923 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232383001924 Cytochrome P450; Region: p450; cl12078 1232383001925 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1232383001926 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1232383001927 Bacterial transcriptional regulator; Region: IclR; pfam01614 1232383001928 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1232383001929 SecY translocase; Region: SecY; pfam00344 1232383001930 adenylate kinase; Reviewed; Region: adk; PRK00279 1232383001931 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1232383001932 AMP-binding site [chemical binding]; other site 1232383001933 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1232383001934 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1232383001935 active site 1232383001936 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1232383001937 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1232383001938 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1232383001939 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1232383001940 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1232383001941 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1232383001942 Right handed beta helix region; Region: Beta_helix; pfam13229 1232383001943 Right handed beta helix region; Region: Beta_helix; pfam13229 1232383001944 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1232383001945 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1232383001946 NAD binding site [chemical binding]; other site 1232383001947 homodimer interface [polypeptide binding]; other site 1232383001948 active site 1232383001949 substrate binding site [chemical binding]; other site 1232383001950 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1232383001951 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1232383001952 DXD motif; other site 1232383001953 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1232383001954 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232383001955 NAD(P) binding site [chemical binding]; other site 1232383001956 active site 1232383001957 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1232383001958 rRNA binding site [nucleotide binding]; other site 1232383001959 predicted 30S ribosome binding site; other site 1232383001960 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 1232383001961 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1232383001962 30S ribosomal protein S11; Validated; Region: PRK05309 1232383001963 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1232383001964 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1232383001965 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1232383001966 RNA binding surface [nucleotide binding]; other site 1232383001967 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1232383001968 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1232383001969 alphaNTD - beta interaction site [polypeptide binding]; other site 1232383001970 alphaNTD homodimer interface [polypeptide binding]; other site 1232383001971 alphaNTD - beta' interaction site [polypeptide binding]; other site 1232383001972 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1232383001973 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1232383001974 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1232383001975 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1232383001976 dimerization interface 3.5A [polypeptide binding]; other site 1232383001977 active site 1232383001978 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1232383001979 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 1232383001980 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1232383001981 FAD binding domain; Region: FAD_binding_4; pfam01565 1232383001982 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1232383001983 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1232383001984 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232383001985 S-adenosylmethionine binding site [chemical binding]; other site 1232383001986 TIGR02611 family protein; Region: TIGR02611 1232383001987 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1232383001988 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1232383001989 active site 1232383001990 catalytic residues [active] 1232383001991 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1232383001992 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1232383001993 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1232383001994 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1232383001995 catalytic residues [active] 1232383001996 catalytic nucleophile [active] 1232383001997 Recombinase; Region: Recombinase; pfam07508 1232383001998 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1232383001999 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 1232383002000 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1232383002001 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1232383002002 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1232383002003 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1232383002004 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1232383002005 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1232383002006 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1232383002007 ATP binding site [chemical binding]; other site 1232383002008 putative Mg++ binding site [ion binding]; other site 1232383002009 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 1232383002010 Domain of unknown function (DUF955); Region: DUF955; cl01076 1232383002011 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1232383002012 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1232383002013 catalytic residues [active] 1232383002014 catalytic nucleophile [active] 1232383002015 Presynaptic Site I dimer interface [polypeptide binding]; other site 1232383002016 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1232383002017 Synaptic Flat tetramer interface [polypeptide binding]; other site 1232383002018 Synaptic Site I dimer interface [polypeptide binding]; other site 1232383002019 DNA binding site [nucleotide binding] 1232383002020 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1232383002021 DNA-binding interface [nucleotide binding]; DNA binding site 1232383002022 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1232383002023 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1232383002024 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1232383002025 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1232383002026 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1232383002027 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1232383002028 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1232383002029 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1232383002030 DDE superfamily endonuclease; Region: DDE_5; pfam13546 1232383002031 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232383002032 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722 1232383002033 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232383002034 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232383002035 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1232383002036 Integrase core domain; Region: rve; pfam00665 1232383002037 Copper resistance protein D; Region: CopD; pfam05425 1232383002038 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1232383002039 DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749 1232383002040 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1232383002041 active site 1232383002042 substrate binding site [chemical binding]; other site 1232383002043 catalytic site [active] 1232383002044 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 1232383002045 active site 1232383002046 DNA binding site [nucleotide binding] 1232383002047 catalytic site [active] 1232383002048 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1232383002049 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1232383002050 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1232383002051 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1232383002052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1232383002053 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1232383002054 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1232383002055 23S rRNA interface [nucleotide binding]; other site 1232383002056 L3 interface [polypeptide binding]; other site 1232383002057 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1232383002058 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1232383002059 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1232383002060 active site 1232383002061 substrate binding site [chemical binding]; other site 1232383002062 metal binding site [ion binding]; metal-binding site 1232383002063 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1232383002064 alanine racemase; Reviewed; Region: alr; PRK00053 1232383002065 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1232383002066 active site 1232383002067 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1232383002068 dimer interface [polypeptide binding]; other site 1232383002069 substrate binding site [chemical binding]; other site 1232383002070 catalytic residues [active] 1232383002071 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1232383002072 Predicted permease [General function prediction only]; Region: COG2985 1232383002073 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1232383002074 TrkA-C domain; Region: TrkA_C; pfam02080 1232383002075 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1232383002076 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1232383002077 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 1232383002078 Glycoprotease family; Region: Peptidase_M22; pfam00814 1232383002079 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1232383002080 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1232383002081 Coenzyme A binding pocket [chemical binding]; other site 1232383002082 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1232383002083 UGMP family protein; Validated; Region: PRK09604 1232383002084 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1232383002085 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1232383002086 putative substrate binding site [chemical binding]; other site 1232383002087 putative ATP binding site [chemical binding]; other site 1232383002088 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1232383002089 oligomerisation interface [polypeptide binding]; other site 1232383002090 mobile loop; other site 1232383002091 roof hairpin; other site 1232383002092 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1232383002093 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1232383002094 ring oligomerisation interface [polypeptide binding]; other site 1232383002095 ATP/Mg binding site [chemical binding]; other site 1232383002096 stacking interactions; other site 1232383002097 hinge regions; other site 1232383002098 Transcription factor WhiB; Region: Whib; pfam02467 1232383002099 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1232383002100 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1232383002101 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1232383002102 DNA binding residues [nucleotide binding] 1232383002103 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1232383002104 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1232383002105 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1232383002106 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1232383002107 active site 1232383002108 IMP dehydrogenase family protein; Region: IMP_DH_rel_2; TIGR01304 1232383002109 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1232383002110 phosphate binding site [ion binding]; other site 1232383002111 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 1232383002112 EamA-like transporter family; Region: EamA; pfam00892 1232383002113 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1232383002114 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1232383002115 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1232383002116 putative dimerization interface [polypeptide binding]; other site 1232383002117 GMP synthase; Reviewed; Region: guaA; PRK00074 1232383002118 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1232383002119 AMP/PPi binding site [chemical binding]; other site 1232383002120 candidate oxyanion hole; other site 1232383002121 catalytic triad [active] 1232383002122 potential glutamine specificity residues [chemical binding]; other site 1232383002123 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1232383002124 ATP Binding subdomain [chemical binding]; other site 1232383002125 Ligand Binding sites [chemical binding]; other site 1232383002126 Dimerization subdomain; other site 1232383002127 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 1232383002128 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1232383002129 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1232383002130 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232383002131 ATP binding site [chemical binding]; other site 1232383002132 Mg2+ binding site [ion binding]; other site 1232383002133 G-X-G motif; other site 1232383002134 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1232383002135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1232383002136 active site 1232383002137 phosphorylation site [posttranslational modification] 1232383002138 intermolecular recognition site; other site 1232383002139 dimerization interface [polypeptide binding]; other site 1232383002140 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1232383002141 dimerization interface [polypeptide binding]; other site 1232383002142 DNA binding residues [nucleotide binding] 1232383002143 DNA Polymerase Y-family; Region: PolY_like; cd03468 1232383002144 active site 1232383002145 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1232383002146 DNA binding site [nucleotide binding] 1232383002147 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 1232383002148 putative dimer interface [polypeptide binding]; other site 1232383002149 putative [2Fe-2S] cluster binding site [ion binding]; other site 1232383002150 prenyltransferase; Reviewed; Region: ubiA; PRK13105 1232383002151 UbiA prenyltransferase family; Region: UbiA; pfam01040 1232383002152 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1232383002153 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1232383002154 phytoene desaturase; Region: crtI_fam; TIGR02734 1232383002155 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1232383002156 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1232383002157 active site lid residues [active] 1232383002158 substrate binding pocket [chemical binding]; other site 1232383002159 catalytic residues [active] 1232383002160 substrate-Mg2+ binding site; other site 1232383002161 aspartate-rich region 1; other site 1232383002162 aspartate-rich region 2; other site 1232383002163 MMPL family; Region: MMPL; pfam03176 1232383002164 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1232383002165 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1232383002166 substrate binding pocket [chemical binding]; other site 1232383002167 chain length determination region; other site 1232383002168 substrate-Mg2+ binding site; other site 1232383002169 catalytic residues [active] 1232383002170 aspartate-rich region 1; other site 1232383002171 active site lid residues [active] 1232383002172 aspartate-rich region 2; other site 1232383002173 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1232383002174 MarR family; Region: MarR_2; pfam12802 1232383002175 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 1232383002176 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1232383002177 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1232383002178 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232383002179 NAD(P) binding site [chemical binding]; other site 1232383002180 active site 1232383002181 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1232383002182 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1232383002183 DNA photolyase; Region: DNA_photolyase; pfam00875 1232383002184 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1232383002185 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1232383002186 active site 1232383002187 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1232383002188 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1232383002189 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1232383002190 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1232383002191 Walker A/P-loop; other site 1232383002192 ATP binding site [chemical binding]; other site 1232383002193 Q-loop/lid; other site 1232383002194 ABC transporter signature motif; other site 1232383002195 Walker B; other site 1232383002196 D-loop; other site 1232383002197 H-loop/switch region; other site 1232383002198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232383002199 dimer interface [polypeptide binding]; other site 1232383002200 conserved gate region; other site 1232383002201 putative PBP binding loops; other site 1232383002202 ABC-ATPase subunit interface; other site 1232383002203 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1232383002204 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1232383002205 Walker A/P-loop; other site 1232383002206 ATP binding site [chemical binding]; other site 1232383002207 Q-loop/lid; other site 1232383002208 ABC transporter signature motif; other site 1232383002209 Walker B; other site 1232383002210 D-loop; other site 1232383002211 H-loop/switch region; other site 1232383002212 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1232383002213 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1232383002214 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1232383002215 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1232383002216 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 1232383002217 active site 1232383002218 PHP Thumb interface [polypeptide binding]; other site 1232383002219 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1232383002220 generic binding surface II; other site 1232383002221 generic binding surface I; other site 1232383002222 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1232383002223 Predicted membrane protein [Function unknown]; Region: COG3428 1232383002224 Bacterial PH domain; Region: DUF304; pfam03703 1232383002225 Bacterial PH domain; Region: DUF304; cl01348 1232383002226 Bacterial PH domain; Region: DUF304; pfam03703 1232383002227 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1232383002228 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1232383002229 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1232383002230 FeoA domain; Region: FeoA; pfam04023 1232383002231 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1232383002232 NAD-dependent deacetylase; Provisional; Region: PRK00481 1232383002233 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1232383002234 NAD+ binding site [chemical binding]; other site 1232383002235 substrate binding site [chemical binding]; other site 1232383002236 Zn binding site [ion binding]; other site 1232383002237 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1232383002238 nucleoside/Zn binding site; other site 1232383002239 dimer interface [polypeptide binding]; other site 1232383002240 catalytic motif [active] 1232383002241 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1232383002242 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1232383002243 siderophore binding site; other site 1232383002244 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1232383002245 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1232383002246 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1232383002247 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1232383002248 homodimer interface [polypeptide binding]; other site 1232383002249 NADP binding site [chemical binding]; other site 1232383002250 substrate binding site [chemical binding]; other site 1232383002251 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1232383002252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1232383002253 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1232383002254 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 1232383002255 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 1232383002256 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1232383002257 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1232383002258 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1232383002259 dimerization interface [polypeptide binding]; other site 1232383002260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383002261 metabolite-proton symporter; Region: 2A0106; TIGR00883 1232383002262 putative substrate translocation pore; other site 1232383002263 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1232383002264 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1232383002265 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 1232383002266 putative substrate binding pocket [chemical binding]; other site 1232383002267 dimerization interface [polypeptide binding]; other site 1232383002268 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 1232383002269 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1232383002270 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1232383002271 homotrimer interaction site [polypeptide binding]; other site 1232383002272 putative active site [active] 1232383002273 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 1232383002274 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1232383002275 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1232383002276 metal binding site [ion binding]; metal-binding site 1232383002277 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1232383002278 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1232383002279 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05613 1232383002280 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1232383002281 homodimer interface [polypeptide binding]; other site 1232383002282 substrate-cofactor binding pocket; other site 1232383002283 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232383002284 catalytic residue [active] 1232383002285 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1232383002286 Carbon starvation protein CstA; Region: CstA; pfam02554 1232383002287 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1232383002288 Protein of unknown function (DUF466); Region: DUF466; pfam04328 1232383002289 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1232383002290 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1232383002291 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1232383002292 tetramer interface [polypeptide binding]; other site 1232383002293 active site 1232383002294 Mg2+/Mn2+ binding site [ion binding]; other site 1232383002295 citrate synthase; Provisional; Region: PRK14033 1232383002296 Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111 1232383002297 dimer interface [polypeptide binding]; other site 1232383002298 active site 1232383002299 citrylCoA binding site [chemical binding]; other site 1232383002300 oxalacetate/citrate binding site [chemical binding]; other site 1232383002301 coenzyme A binding site [chemical binding]; other site 1232383002302 catalytic triad [active] 1232383002303 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1232383002304 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 1232383002305 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1232383002306 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1232383002307 DNA-binding site [nucleotide binding]; DNA binding site 1232383002308 FCD domain; Region: FCD; pfam07729 1232383002309 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1232383002310 Citrate transporter; Region: CitMHS; pfam03600 1232383002311 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1232383002312 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1232383002313 NAD(P) binding site [chemical binding]; other site 1232383002314 catalytic residues [active] 1232383002315 Cupin domain; Region: Cupin_2; pfam07883 1232383002316 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1232383002317 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1232383002318 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1232383002319 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1232383002320 FAD binding pocket [chemical binding]; other site 1232383002321 FAD binding motif [chemical binding]; other site 1232383002322 phosphate binding motif [ion binding]; other site 1232383002323 NAD binding pocket [chemical binding]; other site 1232383002324 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1232383002325 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1232383002326 Walker A/P-loop; other site 1232383002327 ATP binding site [chemical binding]; other site 1232383002328 Q-loop/lid; other site 1232383002329 ABC transporter signature motif; other site 1232383002330 Walker B; other site 1232383002331 D-loop; other site 1232383002332 H-loop/switch region; other site 1232383002333 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1232383002334 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1232383002335 ABC-ATPase subunit interface; other site 1232383002336 dimer interface [polypeptide binding]; other site 1232383002337 putative PBP binding regions; other site 1232383002338 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1232383002339 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1232383002340 ABC-ATPase subunit interface; other site 1232383002341 dimer interface [polypeptide binding]; other site 1232383002342 putative PBP binding regions; other site 1232383002343 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1232383002344 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1232383002345 siderophore binding site; other site 1232383002346 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1232383002347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383002348 putative substrate translocation pore; other site 1232383002349 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1232383002350 putative catalytic site [active] 1232383002351 putative metal binding site [ion binding]; other site 1232383002352 putative phosphate binding site [ion binding]; other site 1232383002353 Predicted membrane protein [Function unknown]; Region: COG2860 1232383002354 UPF0126 domain; Region: UPF0126; pfam03458 1232383002355 UPF0126 domain; Region: UPF0126; pfam03458 1232383002356 Integrase core domain; Region: rve; pfam00665 1232383002357 Integrase core domain; Region: rve_3; pfam13683 1232383002358 hypothetical protein; Validated; Region: PRK09039 1232383002359 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1232383002360 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1232383002361 intersubunit interface [polypeptide binding]; other site 1232383002362 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1232383002363 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1232383002364 Walker A/P-loop; other site 1232383002365 ATP binding site [chemical binding]; other site 1232383002366 Q-loop/lid; other site 1232383002367 ABC transporter signature motif; other site 1232383002368 Walker B; other site 1232383002369 D-loop; other site 1232383002370 H-loop/switch region; other site 1232383002371 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1232383002372 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1232383002373 ABC-ATPase subunit interface; other site 1232383002374 dimer interface [polypeptide binding]; other site 1232383002375 putative PBP binding regions; other site 1232383002376 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1232383002377 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1232383002378 active site 1232383002379 HIGH motif; other site 1232383002380 dimer interface [polypeptide binding]; other site 1232383002381 KMSKS motif; other site 1232383002382 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1232383002383 RDD family; Region: RDD; pfam06271 1232383002384 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1232383002385 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1232383002386 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1232383002387 NlpC/P60 family; Region: NLPC_P60; pfam00877 1232383002388 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1232383002389 active site 1232383002390 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1232383002391 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1232383002392 non-specific DNA binding site [nucleotide binding]; other site 1232383002393 salt bridge; other site 1232383002394 sequence-specific DNA binding site [nucleotide binding]; other site 1232383002395 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1232383002396 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1232383002397 active site 1232383002398 substrate binding site [chemical binding]; other site 1232383002399 metal binding site [ion binding]; metal-binding site 1232383002400 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1232383002401 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1232383002402 metal binding site [ion binding]; metal-binding site 1232383002403 putative dimer interface [polypeptide binding]; other site 1232383002404 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1232383002405 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232383002406 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232383002407 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1232383002408 pyruvate carboxylase; Reviewed; Region: PRK12999 1232383002409 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1232383002410 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1232383002411 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1232383002412 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1232383002413 active site 1232383002414 catalytic residues [active] 1232383002415 metal binding site [ion binding]; metal-binding site 1232383002416 homodimer binding site [polypeptide binding]; other site 1232383002417 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1232383002418 carboxyltransferase (CT) interaction site; other site 1232383002419 biotinylation site [posttranslational modification]; other site 1232383002420 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1232383002421 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1232383002422 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1232383002423 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1232383002424 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1232383002425 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1232383002426 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1232383002427 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1232383002428 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1232383002429 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1232383002430 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1232383002431 tetramer interface [polypeptide binding]; other site 1232383002432 active site 1232383002433 Mg2+/Mn2+ binding site [ion binding]; other site 1232383002434 citrate synthase; Provisional; Region: PRK14033 1232383002435 Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111 1232383002436 dimer interface [polypeptide binding]; other site 1232383002437 active site 1232383002438 citrylCoA binding site [chemical binding]; other site 1232383002439 oxalacetate/citrate binding site [chemical binding]; other site 1232383002440 coenzyme A binding site [chemical binding]; other site 1232383002441 catalytic triad [active] 1232383002442 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1232383002443 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1232383002444 non-specific DNA binding site [nucleotide binding]; other site 1232383002445 salt bridge; other site 1232383002446 sequence-specific DNA binding site [nucleotide binding]; other site 1232383002447 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1232383002448 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1232383002449 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1232383002450 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1232383002451 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1232383002452 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1232383002453 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1232383002454 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1232383002455 carboxyltransferase (CT) interaction site; other site 1232383002456 biotinylation site [posttranslational modification]; other site 1232383002457 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1232383002458 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1232383002459 active site residue [active] 1232383002460 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1232383002461 active site residue [active] 1232383002462 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1232383002463 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1232383002464 Maf-like protein; Region: Maf; pfam02545 1232383002465 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1232383002466 active site 1232383002467 dimer interface [polypeptide binding]; other site 1232383002468 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1232383002469 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1232383002470 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1232383002471 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1232383002472 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1232383002473 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1232383002474 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1232383002475 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1232383002476 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1232383002477 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1232383002478 ATP-grasp domain; Region: ATP-grasp; pfam02222 1232383002479 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 1232383002480 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1232383002481 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1232383002482 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1232383002483 putative active site [active] 1232383002484 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1232383002485 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1232383002486 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1232383002487 active site 1232383002488 non-prolyl cis peptide bond; other site 1232383002489 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 1232383002490 putative beta-ketoacyl acyl carrier protein [ACP]reductase (BKR), subgroup 2, classical (c) SDR; Region: BKR_2_SDR_c; cd05349 1232383002491 putative NAD(P) binding site [chemical binding]; other site 1232383002492 active site 1232383002493 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1232383002494 RibD C-terminal domain; Region: RibD_C; cl17279 1232383002495 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 1232383002496 putative dimer interface [polypeptide binding]; other site 1232383002497 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1232383002498 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1232383002499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232383002500 dimer interface [polypeptide binding]; other site 1232383002501 conserved gate region; other site 1232383002502 putative PBP binding loops; other site 1232383002503 ABC-ATPase subunit interface; other site 1232383002504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232383002505 dimer interface [polypeptide binding]; other site 1232383002506 conserved gate region; other site 1232383002507 putative PBP binding loops; other site 1232383002508 ABC-ATPase subunit interface; other site 1232383002509 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901 1232383002510 putative hydrophobic ligand binding site [chemical binding]; other site 1232383002511 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1232383002512 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1232383002513 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1232383002514 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1232383002515 Walker A/P-loop; other site 1232383002516 ATP binding site [chemical binding]; other site 1232383002517 Q-loop/lid; other site 1232383002518 ABC transporter signature motif; other site 1232383002519 Walker B; other site 1232383002520 D-loop; other site 1232383002521 H-loop/switch region; other site 1232383002522 TOBE domain; Region: TOBE_2; pfam08402 1232383002523 TIGR03089 family protein; Region: TIGR03089 1232383002524 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1232383002525 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1232383002526 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1232383002527 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1232383002528 Probable Catalytic site; other site 1232383002529 metal-binding site 1232383002530 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1232383002531 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1232383002532 active site 1232383002533 Substrate binding site; other site 1232383002534 Mg++ binding site; other site 1232383002535 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1232383002536 putative trimer interface [polypeptide binding]; other site 1232383002537 putative CoA binding site [chemical binding]; other site 1232383002538 Transcription factor WhiB; Region: Whib; pfam02467 1232383002539 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1232383002540 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1232383002541 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1232383002542 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1232383002543 active site 1232383002544 substrate binding site [chemical binding]; other site 1232383002545 metal binding site [ion binding]; metal-binding site 1232383002546 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1232383002547 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1232383002548 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1232383002549 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 1232383002550 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1232383002551 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1232383002552 homotetramer interface [polypeptide binding]; other site 1232383002553 ligand binding site [chemical binding]; other site 1232383002554 catalytic site [active] 1232383002555 NAD binding site [chemical binding]; other site 1232383002556 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1232383002557 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1232383002558 TMP-binding site; other site 1232383002559 ATP-binding site [chemical binding]; other site 1232383002560 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1232383002561 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1232383002562 active site 1232383002563 phosphorylation site [posttranslational modification] 1232383002564 intermolecular recognition site; other site 1232383002565 dimerization interface [polypeptide binding]; other site 1232383002566 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1232383002567 DNA binding site [nucleotide binding] 1232383002568 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1232383002569 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1232383002570 dimerization interface [polypeptide binding]; other site 1232383002571 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1232383002572 dimer interface [polypeptide binding]; other site 1232383002573 phosphorylation site [posttranslational modification] 1232383002574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232383002575 ATP binding site [chemical binding]; other site 1232383002576 Mg2+ binding site [ion binding]; other site 1232383002577 G-X-G motif; other site 1232383002578 lipoprotein LpqB; Provisional; Region: PRK13616 1232383002579 Sporulation and spore germination; Region: Germane; pfam10646 1232383002580 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1232383002581 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1232383002582 active site 1232383002583 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1232383002584 30S subunit binding site; other site 1232383002585 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1232383002586 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1232383002587 ATP binding site [chemical binding]; other site 1232383002588 putative Mg++ binding site [ion binding]; other site 1232383002589 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1232383002590 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1232383002591 nucleotide binding region [chemical binding]; other site 1232383002592 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1232383002593 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 1232383002594 Predicted GTPases [General function prediction only]; Region: COG1162 1232383002595 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1232383002596 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1232383002597 GTP/Mg2+ binding site [chemical binding]; other site 1232383002598 G4 box; other site 1232383002599 G1 box; other site 1232383002600 Switch I region; other site 1232383002601 G2 box; other site 1232383002602 G3 box; other site 1232383002603 Switch II region; other site 1232383002604 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1232383002605 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1232383002606 active site 1232383002607 hinge; other site 1232383002608 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1232383002609 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1232383002610 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1232383002611 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1232383002612 DNA binding residues [nucleotide binding] 1232383002613 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 1232383002614 Transcription factor WhiB; Region: Whib; pfam02467 1232383002615 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1232383002616 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1232383002617 ATP binding site [chemical binding]; other site 1232383002618 Mg++ binding site [ion binding]; other site 1232383002619 motif III; other site 1232383002620 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1232383002621 nucleotide binding region [chemical binding]; other site 1232383002622 ATP-binding site [chemical binding]; other site 1232383002623 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1232383002624 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1232383002625 TIGR02569 family protein; Region: TIGR02569_actnb 1232383002626 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1232383002627 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1232383002628 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1232383002629 Family description; Region: UvrD_C_2; pfam13538 1232383002630 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1232383002631 Ion channel; Region: Ion_trans_2; pfam07885 1232383002632 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1232383002633 TrkA-N domain; Region: TrkA_N; pfam02254 1232383002634 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 1232383002635 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1232383002636 putative NADH binding site [chemical binding]; other site 1232383002637 putative active site [active] 1232383002638 nudix motif; other site 1232383002639 putative metal binding site [ion binding]; other site 1232383002640 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1232383002641 Part of AAA domain; Region: AAA_19; pfam13245 1232383002642 Family description; Region: UvrD_C_2; pfam13538 1232383002643 HRDC domain; Region: HRDC; pfam00570 1232383002644 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1232383002645 Uncharacterized conserved protein [Function unknown]; Region: COG5282 1232383002646 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1232383002647 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1232383002648 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1232383002649 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1232383002650 hypothetical protein; Validated; Region: PRK00068 1232383002651 Uncharacterized conserved protein [Function unknown]; Region: COG1615 1232383002652 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1232383002653 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1232383002654 DNA-binding site [nucleotide binding]; DNA binding site 1232383002655 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1232383002656 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232383002657 homodimer interface [polypeptide binding]; other site 1232383002658 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1232383002659 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1232383002660 active site 1232383002661 multimer interface [polypeptide binding]; other site 1232383002662 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1232383002663 predicted active site [active] 1232383002664 catalytic triad [active] 1232383002665 SdpI/YhfL protein family; Region: SdpI; pfam13630 1232383002666 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1232383002667 substrate binding sites [chemical binding]; other site 1232383002668 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1232383002669 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1232383002670 active site 1232383002671 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1232383002672 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1232383002673 active site 1232383002674 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1232383002675 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1232383002676 RF-1 domain; Region: RF-1; pfam00472 1232383002677 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1232383002678 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232383002679 Walker A/P-loop; other site 1232383002680 ATP binding site [chemical binding]; other site 1232383002681 Q-loop/lid; other site 1232383002682 ABC transporter signature motif; other site 1232383002683 Walker B; other site 1232383002684 D-loop; other site 1232383002685 H-loop/switch region; other site 1232383002686 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1232383002687 FtsX-like permease family; Region: FtsX; pfam02687 1232383002688 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1232383002689 SmpB-tmRNA interface; other site 1232383002690 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1232383002691 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1232383002692 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1232383002693 active site 1232383002694 catalytic residues [active] 1232383002695 DNA binding site [nucleotide binding] 1232383002696 Int/Topo IB signature motif; other site 1232383002697 Helix-turn-helix domain; Region: HTH_17; cl17695 1232383002698 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 1232383002699 polymerase nucleotide-binding site; other site 1232383002700 DNA-binding residues [nucleotide binding]; DNA binding site 1232383002701 nucleotide binding site [chemical binding]; other site 1232383002702 primase nucleotide-binding site [nucleotide binding]; other site 1232383002703 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 1232383002704 Virulence-associated protein E; Region: VirE; pfam05272 1232383002705 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1232383002706 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1232383002707 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1232383002708 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1232383002709 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1232383002710 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1232383002711 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1232383002712 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 1232383002713 GIY-YIG motif/motif A; other site 1232383002714 putative active site [active] 1232383002715 putative metal binding site [ion binding]; other site 1232383002716 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 1232383002717 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 1232383002718 cytidine deaminase; Validated; Region: PRK08298 1232383002719 active site 1232383002720 Zn binding site [ion binding]; other site 1232383002721 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1232383002722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232383002723 dimer interface [polypeptide binding]; other site 1232383002724 conserved gate region; other site 1232383002725 putative PBP binding loops; other site 1232383002726 ABC-ATPase subunit interface; other site 1232383002727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232383002728 dimer interface [polypeptide binding]; other site 1232383002729 conserved gate region; other site 1232383002730 putative PBP binding loops; other site 1232383002731 ABC-ATPase subunit interface; other site 1232383002732 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 1232383002733 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1232383002734 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1232383002735 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1232383002736 Walker A/P-loop; other site 1232383002737 ATP binding site [chemical binding]; other site 1232383002738 Q-loop/lid; other site 1232383002739 ABC transporter signature motif; other site 1232383002740 Walker B; other site 1232383002741 D-loop; other site 1232383002742 H-loop/switch region; other site 1232383002743 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1232383002744 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1232383002745 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1232383002746 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1232383002747 cofactor binding site; other site 1232383002748 DNA binding site [nucleotide binding] 1232383002749 substrate interaction site [chemical binding]; other site 1232383002750 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1232383002751 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1232383002752 FAD binding pocket [chemical binding]; other site 1232383002753 FAD binding motif [chemical binding]; other site 1232383002754 phosphate binding motif [ion binding]; other site 1232383002755 NAD binding pocket [chemical binding]; other site 1232383002756 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1232383002757 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1232383002758 siderophore binding site; other site 1232383002759 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1232383002760 putative active site [active] 1232383002761 redox center [active] 1232383002762 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1232383002763 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1232383002764 intersubunit interface [polypeptide binding]; other site 1232383002765 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1232383002766 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1232383002767 ABC-ATPase subunit interface; other site 1232383002768 dimer interface [polypeptide binding]; other site 1232383002769 putative PBP binding regions; other site 1232383002770 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1232383002771 ABC-ATPase subunit interface; other site 1232383002772 dimer interface [polypeptide binding]; other site 1232383002773 putative PBP binding regions; other site 1232383002774 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1232383002775 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1232383002776 Walker A/P-loop; other site 1232383002777 ATP binding site [chemical binding]; other site 1232383002778 Q-loop/lid; other site 1232383002779 ABC transporter signature motif; other site 1232383002780 Walker B; other site 1232383002781 D-loop; other site 1232383002782 H-loop/switch region; other site 1232383002783 aminotransferase; Validated; Region: PRK07777 1232383002784 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1232383002785 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232383002786 homodimer interface [polypeptide binding]; other site 1232383002787 catalytic residue [active] 1232383002788 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 1232383002789 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1232383002790 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1232383002791 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1232383002792 ATP binding site [chemical binding]; other site 1232383002793 putative Mg++ binding site [ion binding]; other site 1232383002794 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1232383002795 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1232383002796 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1232383002797 Protein of unknown function (DUF3235); Region: DUF3235; pfam11574 1232383002798 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1232383002799 DNA-binding site [nucleotide binding]; DNA binding site 1232383002800 RNA-binding motif; other site 1232383002801 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 1232383002802 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 1232383002803 substrate-cofactor binding pocket; other site 1232383002804 homodimer interface [polypeptide binding]; other site 1232383002805 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1232383002806 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1232383002807 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232383002808 catalytic residue [active] 1232383002809 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1232383002810 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1232383002811 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 1232383002812 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1232383002813 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1232383002814 phosphoserine aminotransferase, putative; Region: serC_3; TIGR01366 1232383002815 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1232383002816 catalytic residue [active] 1232383002817 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1232383002818 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1232383002819 dimer interface [polypeptide binding]; other site 1232383002820 active site 1232383002821 citrylCoA binding site [chemical binding]; other site 1232383002822 NADH binding [chemical binding]; other site 1232383002823 cationic pore residues; other site 1232383002824 oxalacetate/citrate binding site [chemical binding]; other site 1232383002825 coenzyme A binding site [chemical binding]; other site 1232383002826 catalytic triad [active] 1232383002827 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1232383002828 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1232383002829 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 1232383002830 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1232383002831 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1232383002832 Predicted membrane protein [Function unknown]; Region: COG3162 1232383002833 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1232383002834 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1232383002835 Na binding site [ion binding]; other site 1232383002836 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1232383002837 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1232383002838 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1232383002839 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1232383002840 phosphate binding site [ion binding]; other site 1232383002841 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1232383002842 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1232383002843 active site 2 [active] 1232383002844 active site 1 [active] 1232383002845 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1232383002846 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1232383002847 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1232383002848 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1232383002849 putative NAD(P) binding site [chemical binding]; other site 1232383002850 active site 1232383002851 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1232383002852 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1232383002853 active site 1232383002854 Septum formation; Region: Septum_form; pfam13845 1232383002855 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1232383002856 hypothetical protein; Validated; Region: PRK07581 1232383002857 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1232383002858 catalytic residues [active] 1232383002859 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1232383002860 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1232383002861 folate binding site [chemical binding]; other site 1232383002862 NADP+ binding site [chemical binding]; other site 1232383002863 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1232383002864 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1232383002865 dimerization interface [polypeptide binding]; other site 1232383002866 active site 1232383002867 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1232383002868 active site 1232383002869 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1232383002870 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1232383002871 ATP binding site [chemical binding]; other site 1232383002872 putative Mg++ binding site [ion binding]; other site 1232383002873 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1232383002874 nucleotide binding region [chemical binding]; other site 1232383002875 ATP-binding site [chemical binding]; other site 1232383002876 DEAD/H associated; Region: DEAD_assoc; pfam08494 1232383002877 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1232383002878 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1232383002879 putative DNA binding site [nucleotide binding]; other site 1232383002880 catalytic residue [active] 1232383002881 putative H2TH interface [polypeptide binding]; other site 1232383002882 putative catalytic residues [active] 1232383002883 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1232383002884 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1232383002885 Predicted membrane protein [Function unknown]; Region: COG3304 1232383002886 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1232383002887 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1232383002888 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1232383002889 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1232383002890 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1232383002891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383002892 putative substrate translocation pore; other site 1232383002893 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1232383002894 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1232383002895 active site 1232383002896 dimer interface [polypeptide binding]; other site 1232383002897 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1232383002898 dimer interface [polypeptide binding]; other site 1232383002899 active site 1232383002900 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1232383002901 active site 1232383002902 hypothetical protein; Provisional; Region: PRK07857 1232383002903 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1232383002904 Part of AAA domain; Region: AAA_19; pfam13245 1232383002905 Family description; Region: UvrD_C_2; pfam13538 1232383002906 FtsX-like permease family; Region: FtsX; pfam02687 1232383002907 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1232383002908 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1232383002909 Walker A/P-loop; other site 1232383002910 ATP binding site [chemical binding]; other site 1232383002911 Q-loop/lid; other site 1232383002912 ABC transporter signature motif; other site 1232383002913 Walker B; other site 1232383002914 D-loop; other site 1232383002915 H-loop/switch region; other site 1232383002916 Predicted transcriptional regulators [Transcription]; Region: COG1695 1232383002917 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1232383002918 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1232383002919 Peptidase family M23; Region: Peptidase_M23; pfam01551 1232383002920 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1232383002921 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1232383002922 active site 1232383002923 substrate binding site [chemical binding]; other site 1232383002924 cosubstrate binding site; other site 1232383002925 catalytic site [active] 1232383002926 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1232383002927 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1232383002928 purine monophosphate binding site [chemical binding]; other site 1232383002929 dimer interface [polypeptide binding]; other site 1232383002930 putative catalytic residues [active] 1232383002931 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1232383002932 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1232383002933 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1232383002934 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232383002935 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232383002936 30S ribosomal protein S18; Provisional; Region: PRK13401 1232383002937 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1232383002938 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1232383002939 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1232383002940 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1232383002941 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1232383002942 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1232383002943 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1232383002944 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1232383002945 dimerization interface [polypeptide binding]; other site 1232383002946 putative DNA binding site [nucleotide binding]; other site 1232383002947 putative Zn2+ binding site [ion binding]; other site 1232383002948 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1232383002949 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 1232383002950 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1232383002951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1232383002952 active site 1232383002953 phosphorylation site [posttranslational modification] 1232383002954 intermolecular recognition site; other site 1232383002955 dimerization interface [polypeptide binding]; other site 1232383002956 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1232383002957 DNA binding site [nucleotide binding] 1232383002958 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1232383002959 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1232383002960 dimerization interface [polypeptide binding]; other site 1232383002961 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1232383002962 dimer interface [polypeptide binding]; other site 1232383002963 phosphorylation site [posttranslational modification] 1232383002964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232383002965 ATP binding site [chemical binding]; other site 1232383002966 Mg2+ binding site [ion binding]; other site 1232383002967 G-X-G motif; other site 1232383002968 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1232383002969 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1232383002970 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1232383002971 protein binding site [polypeptide binding]; other site 1232383002972 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1232383002973 MPT binding site; other site 1232383002974 trimer interface [polypeptide binding]; other site 1232383002975 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1232383002976 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1232383002977 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1232383002978 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1232383002979 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1232383002980 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1232383002981 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1232383002982 active site 1232383002983 tetramer interface; other site 1232383002984 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1232383002985 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1232383002986 dimer interface [polypeptide binding]; other site 1232383002987 putative functional site; other site 1232383002988 putative MPT binding site; other site 1232383002989 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1232383002990 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1232383002991 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1232383002992 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383002993 putative substrate translocation pore; other site 1232383002994 Predicted membrane protein [Function unknown]; Region: COG2259 1232383002995 Predicted integral membrane protein [Function unknown]; Region: COG5660 1232383002996 Putative zinc-finger; Region: zf-HC2; pfam13490 1232383002997 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 1232383002998 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1232383002999 active site 1232383003000 catalytic site [active] 1232383003001 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1232383003002 Predicted methyltransferases [General function prediction only]; Region: COG0313 1232383003003 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1232383003004 putative SAM binding site [chemical binding]; other site 1232383003005 putative homodimer interface [polypeptide binding]; other site 1232383003006 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1232383003007 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1232383003008 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1232383003009 active site 1232383003010 HIGH motif; other site 1232383003011 KMSKS motif; other site 1232383003012 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1232383003013 tRNA binding surface [nucleotide binding]; other site 1232383003014 anticodon binding site; other site 1232383003015 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1232383003016 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1232383003017 ATP binding site [chemical binding]; other site 1232383003018 putative Mg++ binding site [ion binding]; other site 1232383003019 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1232383003020 nucleotide binding region [chemical binding]; other site 1232383003021 ATP-binding site [chemical binding]; other site 1232383003022 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1232383003023 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1232383003024 active site 1232383003025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1232383003026 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1232383003027 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1232383003028 G5 domain; Region: G5; pfam07501 1232383003029 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1232383003030 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1232383003031 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232383003032 S-adenosylmethionine binding site [chemical binding]; other site 1232383003033 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1232383003034 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1232383003035 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1232383003036 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1232383003037 ABC transporter; Region: ABC_tran_2; pfam12848 1232383003038 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1232383003039 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1232383003040 dimer interface [polypeptide binding]; other site 1232383003041 pyridoxal binding site [chemical binding]; other site 1232383003042 ATP binding site [chemical binding]; other site 1232383003043 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1232383003044 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1232383003045 catalytic residues [active] 1232383003046 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1232383003047 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1232383003048 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1232383003049 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1232383003050 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232383003051 active site 1232383003052 motif I; other site 1232383003053 motif II; other site 1232383003054 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232383003055 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1232383003056 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232383003057 substrate binding site [chemical binding]; other site 1232383003058 oxyanion hole (OAH) forming residues; other site 1232383003059 trimer interface [polypeptide binding]; other site 1232383003060 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1232383003061 Predicted membrane protein [General function prediction only]; Region: COG4194 1232383003062 Predicted esterase [General function prediction only]; Region: COG0627 1232383003063 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232383003064 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1232383003065 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1232383003066 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 1232383003067 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1232383003068 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1232383003069 active site 1232383003070 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 1232383003071 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1232383003072 G1 box; other site 1232383003073 putative GEF interaction site [polypeptide binding]; other site 1232383003074 GTP/Mg2+ binding site [chemical binding]; other site 1232383003075 Switch I region; other site 1232383003076 G2 box; other site 1232383003077 G3 box; other site 1232383003078 Switch II region; other site 1232383003079 G4 box; other site 1232383003080 G5 box; other site 1232383003081 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1232383003082 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1232383003083 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1232383003084 putative ligand binding site [chemical binding]; other site 1232383003085 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1232383003086 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1232383003087 TM-ABC transporter signature motif; other site 1232383003088 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1232383003089 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1232383003090 TM-ABC transporter signature motif; other site 1232383003091 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1232383003092 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1232383003093 Walker A/P-loop; other site 1232383003094 ATP binding site [chemical binding]; other site 1232383003095 Q-loop/lid; other site 1232383003096 ABC transporter signature motif; other site 1232383003097 Walker B; other site 1232383003098 D-loop; other site 1232383003099 H-loop/switch region; other site 1232383003100 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1232383003101 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1232383003102 Walker A/P-loop; other site 1232383003103 ATP binding site [chemical binding]; other site 1232383003104 Q-loop/lid; other site 1232383003105 ABC transporter signature motif; other site 1232383003106 Walker B; other site 1232383003107 D-loop; other site 1232383003108 H-loop/switch region; other site 1232383003109 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1232383003110 putative active site [active] 1232383003111 catalytic residue [active] 1232383003112 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1232383003113 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1232383003114 FMN binding site [chemical binding]; other site 1232383003115 substrate binding site [chemical binding]; other site 1232383003116 putative catalytic residue [active] 1232383003117 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 1232383003118 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1232383003119 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1232383003120 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1232383003121 putative active site [active] 1232383003122 catalytic residue [active] 1232383003123 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1232383003124 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1232383003125 5S rRNA interface [nucleotide binding]; other site 1232383003126 CTC domain interface [polypeptide binding]; other site 1232383003127 L16 interface [polypeptide binding]; other site 1232383003128 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1232383003129 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1232383003130 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1232383003131 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 1232383003132 active site 1232383003133 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1232383003134 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1232383003135 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1232383003136 active site 1232383003137 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1232383003138 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1232383003139 Substrate binding site; other site 1232383003140 Mg++ binding site; other site 1232383003141 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1232383003142 active site 1232383003143 substrate binding site [chemical binding]; other site 1232383003144 CoA binding site [chemical binding]; other site 1232383003145 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1232383003146 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1232383003147 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1232383003148 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1232383003149 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1232383003150 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1232383003151 Walker A/P-loop; other site 1232383003152 ATP binding site [chemical binding]; other site 1232383003153 Q-loop/lid; other site 1232383003154 ABC transporter signature motif; other site 1232383003155 Walker B; other site 1232383003156 D-loop; other site 1232383003157 H-loop/switch region; other site 1232383003158 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1232383003159 Histidine kinase; Region: HisKA_3; pfam07730 1232383003160 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1232383003161 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1232383003162 active site 1232383003163 phosphorylation site [posttranslational modification] 1232383003164 intermolecular recognition site; other site 1232383003165 dimerization interface [polypeptide binding]; other site 1232383003166 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1232383003167 DNA binding residues [nucleotide binding] 1232383003168 dimerization interface [polypeptide binding]; other site 1232383003169 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1232383003170 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1232383003171 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1232383003172 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232383003173 ABC transporter signature motif; other site 1232383003174 Walker B; other site 1232383003175 D-loop; other site 1232383003176 H-loop/switch region; other site 1232383003177 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1232383003178 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1232383003179 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232383003180 Walker A/P-loop; other site 1232383003181 ATP binding site [chemical binding]; other site 1232383003182 Q-loop/lid; other site 1232383003183 ABC transporter signature motif; other site 1232383003184 Walker B; other site 1232383003185 D-loop; other site 1232383003186 H-loop/switch region; other site 1232383003187 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1232383003188 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1232383003189 UTP:GlnB (protein PII) uridylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: GlnD; COG2844 1232383003190 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 1232383003191 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232383003192 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232383003193 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1232383003194 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1232383003195 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1232383003196 ATP binding site [chemical binding]; other site 1232383003197 putative Mg++ binding site [ion binding]; other site 1232383003198 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1232383003199 nucleotide binding region [chemical binding]; other site 1232383003200 ATP-binding site [chemical binding]; other site 1232383003201 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1232383003202 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1232383003203 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1232383003204 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1232383003205 Walker A/P-loop; other site 1232383003206 ATP binding site [chemical binding]; other site 1232383003207 Q-loop/lid; other site 1232383003208 ABC transporter signature motif; other site 1232383003209 Walker B; other site 1232383003210 D-loop; other site 1232383003211 H-loop/switch region; other site 1232383003212 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1232383003213 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1232383003214 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232383003215 Walker A/P-loop; other site 1232383003216 ATP binding site [chemical binding]; other site 1232383003217 Q-loop/lid; other site 1232383003218 ABC transporter signature motif; other site 1232383003219 Walker B; other site 1232383003220 D-loop; other site 1232383003221 H-loop/switch region; other site 1232383003222 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1232383003223 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1232383003224 Predicted esterase [General function prediction only]; Region: COG0627 1232383003225 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1232383003226 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 1232383003227 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1232383003228 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1232383003229 homodimer interface [polypeptide binding]; other site 1232383003230 metal binding site [ion binding]; metal-binding site 1232383003231 Alpha helical Porin B; Region: PorB; pfam11565 1232383003232 Alpha helical Porin B; Region: PorB; pfam11565 1232383003233 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1232383003234 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1232383003235 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1232383003236 enolase; Provisional; Region: eno; PRK00077 1232383003237 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1232383003238 dimer interface [polypeptide binding]; other site 1232383003239 metal binding site [ion binding]; metal-binding site 1232383003240 substrate binding pocket [chemical binding]; other site 1232383003241 Septum formation initiator; Region: DivIC; pfam04977 1232383003242 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1232383003243 Uncharacterized conserved protein [Function unknown]; Region: COG1507 1232383003244 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1232383003245 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1232383003246 potential frameshift: common BLAST hit: gi|62389871|ref|YP_225273.1| pyrimidine reductase, riboflavin biosynthesis 1232383003247 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1232383003248 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1232383003249 Predicted membrane protein [Function unknown]; Region: COG4760 1232383003250 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1232383003251 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1232383003252 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1232383003253 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1232383003254 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 1232383003255 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1232383003256 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1232383003257 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14828 1232383003258 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1232383003259 catalytic residue [active] 1232383003260 putative FPP diphosphate binding site; other site 1232383003261 putative FPP binding hydrophobic cleft; other site 1232383003262 dimer interface [polypeptide binding]; other site 1232383003263 putative IPP diphosphate binding site; other site 1232383003264 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 1232383003265 pantothenate kinase; Provisional; Region: PRK05439 1232383003266 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1232383003267 ATP-binding site [chemical binding]; other site 1232383003268 CoA-binding site [chemical binding]; other site 1232383003269 Mg2+-binding site [ion binding]; other site 1232383003270 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1232383003271 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1232383003272 dimer interface [polypeptide binding]; other site 1232383003273 active site 1232383003274 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1232383003275 folate binding site [chemical binding]; other site 1232383003276 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1232383003277 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1232383003278 glutamine binding [chemical binding]; other site 1232383003279 catalytic triad [active] 1232383003280 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1232383003281 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 1232383003282 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1232383003283 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1232383003284 substrate-cofactor binding pocket; other site 1232383003285 homodimer interface [polypeptide binding]; other site 1232383003286 Aminotransferase class IV; Region: Aminotran_4; pfam01063 1232383003287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232383003288 catalytic residue [active] 1232383003289 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1232383003290 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1232383003291 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1232383003292 Coenzyme A binding pocket [chemical binding]; other site 1232383003293 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1232383003294 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1232383003295 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1232383003296 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1232383003297 putative active site [active] 1232383003298 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1232383003299 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1232383003300 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1232383003301 DNA-binding site [nucleotide binding]; DNA binding site 1232383003302 FCD domain; Region: FCD; pfam07729 1232383003303 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1232383003304 Class II fumarases; Region: Fumarase_classII; cd01362 1232383003305 active site 1232383003306 tetramer interface [polypeptide binding]; other site 1232383003307 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1232383003308 Predicted flavoprotein [General function prediction only]; Region: COG0431 1232383003309 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1232383003310 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1232383003311 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1232383003312 putative active site [active] 1232383003313 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1232383003314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383003315 MFS transport protein AraJ; Provisional; Region: PRK10091 1232383003316 putative substrate translocation pore; other site 1232383003317 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1232383003318 MarR family; Region: MarR_2; pfam12802 1232383003319 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1232383003320 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1232383003321 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1232383003322 generic binding surface II; other site 1232383003323 generic binding surface I; other site 1232383003324 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1232383003325 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1232383003326 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1232383003327 Membrane protein of unknown function; Region: DUF360; pfam04020 1232383003328 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1232383003329 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1232383003330 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 1232383003331 Na2 binding site [ion binding]; other site 1232383003332 putative substrate binding site 1 [chemical binding]; other site 1232383003333 Na binding site 1 [ion binding]; other site 1232383003334 putative substrate binding site 2 [chemical binding]; other site 1232383003335 Putative esterase; Region: Esterase; pfam00756 1232383003336 GTP-binding protein YchF; Reviewed; Region: PRK09601 1232383003337 YchF GTPase; Region: YchF; cd01900 1232383003338 G1 box; other site 1232383003339 GTP/Mg2+ binding site [chemical binding]; other site 1232383003340 Switch I region; other site 1232383003341 G2 box; other site 1232383003342 Switch II region; other site 1232383003343 G3 box; other site 1232383003344 G4 box; other site 1232383003345 G5 box; other site 1232383003346 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1232383003347 short chain dehydrogenase; Validated; Region: PRK06182 1232383003348 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1232383003349 NADP binding site [chemical binding]; other site 1232383003350 active site 1232383003351 steroid binding site; other site 1232383003352 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232383003353 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232383003354 potential frameshift: common BLAST hit: gi|62389921|ref|YP_225323.1| ornithine carbamoyltransferase 1232383003355 MASE1; Region: MASE1; pfam05231 1232383003356 PAS domain S-box; Region: sensory_box; TIGR00229 1232383003357 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1232383003358 putative active site [active] 1232383003359 heme pocket [chemical binding]; other site 1232383003360 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1232383003361 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1232383003362 metal binding site [ion binding]; metal-binding site 1232383003363 active site 1232383003364 I-site; other site 1232383003365 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1232383003366 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1232383003367 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1232383003368 DXD motif; other site 1232383003369 NNMT/PNMT/TEMT family; Region: NNMT_PNMT_TEMT; pfam01234 1232383003370 potential frameshift: common BLAST hit: gi|227832538|ref|YP_002834245.1| L-aspartate dehydrogenase 1232383003371 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1232383003372 Domain of unknown function DUF108; Region: DUF108; pfam01958 1232383003373 Protein of unknown function (DUF2872); Region: DUF2872; pfam11071 1232383003374 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1232383003375 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 1232383003376 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1232383003377 nudix motif; other site 1232383003378 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1232383003379 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1232383003380 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1232383003381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383003382 putative substrate translocation pore; other site 1232383003383 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1232383003384 MarR family; Region: MarR_2; pfam12802 1232383003385 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 1232383003386 Protein of unknown function, DUF488; Region: DUF488; pfam04343 1232383003387 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1232383003388 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1232383003389 NAD(P) binding site [chemical binding]; other site 1232383003390 putative active site [active] 1232383003391 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1232383003392 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1232383003393 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1232383003394 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1232383003395 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 1232383003396 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1232383003397 metal ion-dependent adhesion site (MIDAS); other site 1232383003398 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 1232383003399 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1232383003400 catalytic core [active] 1232383003401 conserved hypothetical protein; Region: TIGR03843 1232383003402 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1232383003403 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1232383003404 tetramer interface [polypeptide binding]; other site 1232383003405 active site 1232383003406 Mg2+/Mn2+ binding site [ion binding]; other site 1232383003407 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1232383003408 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232383003409 Walker A/P-loop; other site 1232383003410 ATP binding site [chemical binding]; other site 1232383003411 Q-loop/lid; other site 1232383003412 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1232383003413 ABC transporter signature motif; other site 1232383003414 Walker B; other site 1232383003415 D-loop; other site 1232383003416 ABC transporter; Region: ABC_tran_2; pfam12848 1232383003417 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1232383003418 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1232383003419 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1232383003420 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1232383003421 PhnA protein; Region: PhnA; pfam03831 1232383003422 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1232383003423 putative DNA binding site [nucleotide binding]; other site 1232383003424 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1232383003425 putative Zn2+ binding site [ion binding]; other site 1232383003426 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383003427 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1232383003428 putative substrate translocation pore; other site 1232383003429 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1232383003430 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1232383003431 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1232383003432 catalytic residue [active] 1232383003433 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543 1232383003434 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1232383003435 dimerization interface [polypeptide binding]; other site 1232383003436 active site 1232383003437 quinolinate synthetase; Provisional; Region: PRK09375 1232383003438 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1232383003439 nudix motif; other site 1232383003440 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1232383003441 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1232383003442 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1232383003443 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1232383003444 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1232383003445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1232383003446 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1232383003447 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1232383003448 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232383003449 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1232383003450 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1232383003451 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1232383003452 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1232383003453 dimerization interface [polypeptide binding]; other site 1232383003454 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232383003455 Cytochrome P450; Region: p450; cl12078 1232383003456 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1232383003457 dimer interface [polypeptide binding]; other site 1232383003458 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1232383003459 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1232383003460 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 1232383003461 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1232383003462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383003463 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 1232383003464 putative substrate translocation pore; other site 1232383003465 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1232383003466 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1232383003467 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1232383003468 hypothetical protein; Provisional; Region: PRK06847 1232383003469 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1232383003470 active site 1232383003471 Phosphotriesterase family; Region: PTE; cl17343 1232383003472 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1232383003473 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1232383003474 DNA-binding site [nucleotide binding]; DNA binding site 1232383003475 UTRA domain; Region: UTRA; pfam07702 1232383003476 benzoate transport; Region: 2A0115; TIGR00895 1232383003477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383003478 putative substrate translocation pore; other site 1232383003479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383003480 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1232383003481 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1232383003482 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 1232383003483 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1232383003484 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1232383003485 Walker A/P-loop; other site 1232383003486 ATP binding site [chemical binding]; other site 1232383003487 Q-loop/lid; other site 1232383003488 ABC transporter signature motif; other site 1232383003489 Walker B; other site 1232383003490 D-loop; other site 1232383003491 H-loop/switch region; other site 1232383003492 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1232383003493 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1232383003494 Walker A/P-loop; other site 1232383003495 ATP binding site [chemical binding]; other site 1232383003496 Q-loop/lid; other site 1232383003497 ABC transporter signature motif; other site 1232383003498 Walker B; other site 1232383003499 D-loop; other site 1232383003500 H-loop/switch region; other site 1232383003501 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1232383003502 hypothetical protein; Provisional; Region: PRK06547 1232383003503 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 1232383003504 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1232383003505 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1232383003506 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1232383003507 Predicted integral membrane protein [Function unknown]; Region: COG5522 1232383003508 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232383003509 Walker A/P-loop; other site 1232383003510 ATP binding site [chemical binding]; other site 1232383003511 Q-loop/lid; other site 1232383003512 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1232383003513 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232383003514 ABC transporter signature motif; other site 1232383003515 Walker B; other site 1232383003516 D-loop; other site 1232383003517 H-loop/switch region; other site 1232383003518 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232383003519 Walker A/P-loop; other site 1232383003520 ATP binding site [chemical binding]; other site 1232383003521 Q-loop/lid; other site 1232383003522 ABC transporter signature motif; other site 1232383003523 Walker B; other site 1232383003524 D-loop; other site 1232383003525 H-loop/switch region; other site 1232383003526 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1232383003527 dimer interface [polypeptide binding]; other site 1232383003528 catalytic triad [active] 1232383003529 peroxidatic and resolving cysteines [active] 1232383003530 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 1232383003531 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 1232383003532 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1232383003533 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1232383003534 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424 1232383003535 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1232383003536 nudix motif; other site 1232383003537 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1232383003538 Trypsin; Region: Trypsin; pfam00089 1232383003539 active site 1232383003540 substrate binding sites [chemical binding]; other site 1232383003541 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1232383003542 ArsC family; Region: ArsC; pfam03960 1232383003543 catalytic residues [active] 1232383003544 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1232383003545 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 1232383003546 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1232383003547 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1232383003548 G1 box; other site 1232383003549 GTP/Mg2+ binding site [chemical binding]; other site 1232383003550 G2 box; other site 1232383003551 Switch I region; other site 1232383003552 G3 box; other site 1232383003553 Switch II region; other site 1232383003554 G4 box; other site 1232383003555 G5 box; other site 1232383003556 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1232383003557 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1232383003558 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1232383003559 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1232383003560 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1232383003561 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1232383003562 Ferredoxin [Energy production and conversion]; Region: COG1146 1232383003563 4Fe-4S binding domain; Region: Fer4; pfam00037 1232383003564 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1232383003565 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1232383003566 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232383003567 homodimer interface [polypeptide binding]; other site 1232383003568 catalytic residue [active] 1232383003569 Predicted membrane protein [Function unknown]; Region: COG2246 1232383003570 GtrA-like protein; Region: GtrA; pfam04138 1232383003571 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1232383003572 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1232383003573 active site 1232383003574 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1232383003575 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1232383003576 putative trimer interface [polypeptide binding]; other site 1232383003577 putative CoA binding site [chemical binding]; other site 1232383003578 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1232383003579 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1232383003580 Tetrahydrodipicolinate N-succinyltransferase [Amino acid transport and metabolism]; Region: DapD; COG2171 1232383003581 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1232383003582 putative trimer interface [polypeptide binding]; other site 1232383003583 putative CoA binding site [chemical binding]; other site 1232383003584 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1232383003585 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1232383003586 metal binding site [ion binding]; metal-binding site 1232383003587 putative dimer interface [polypeptide binding]; other site 1232383003588 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1232383003589 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1232383003590 dihydropteroate synthase; Region: DHPS; TIGR01496 1232383003591 substrate binding pocket [chemical binding]; other site 1232383003592 dimer interface [polypeptide binding]; other site 1232383003593 inhibitor binding site; inhibition site 1232383003594 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 1232383003595 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1232383003596 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1232383003597 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1232383003598 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232383003599 S-adenosylmethionine binding site [chemical binding]; other site 1232383003600 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1232383003601 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1232383003602 active site 1232383003603 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1232383003604 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1232383003605 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1232383003606 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1232383003607 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1232383003608 ligand binding site; other site 1232383003609 oligomer interface; other site 1232383003610 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1232383003611 sulfate 1 binding site; other site 1232383003612 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1232383003613 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1232383003614 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 1232383003615 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1232383003616 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1232383003617 DNA binding residues [nucleotide binding] 1232383003618 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 1232383003619 sec-independent translocase; Provisional; Region: tatB; PRK00182 1232383003620 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1232383003621 Domain of unknown function DUF59; Region: DUF59; pfam01883 1232383003622 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1232383003623 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1232383003624 Predicted membrane protein [Function unknown]; Region: COG4420 1232383003625 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1232383003626 MgtE intracellular N domain; Region: MgtE_N; smart00924 1232383003627 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1232383003628 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1232383003629 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1232383003630 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1232383003631 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1232383003632 TPP-binding site [chemical binding]; other site 1232383003633 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1232383003634 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1232383003635 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1232383003636 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232383003637 Walker A/P-loop; other site 1232383003638 ATP binding site [chemical binding]; other site 1232383003639 Q-loop/lid; other site 1232383003640 ABC transporter signature motif; other site 1232383003641 Walker B; other site 1232383003642 D-loop; other site 1232383003643 H-loop/switch region; other site 1232383003644 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1232383003645 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1232383003646 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232383003647 Walker A/P-loop; other site 1232383003648 ATP binding site [chemical binding]; other site 1232383003649 Q-loop/lid; other site 1232383003650 ABC transporter signature motif; other site 1232383003651 Walker B; other site 1232383003652 D-loop; other site 1232383003653 H-loop/switch region; other site 1232383003654 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 1232383003655 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1232383003656 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1232383003657 shikimate binding site; other site 1232383003658 NAD(P) binding site [chemical binding]; other site 1232383003659 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1232383003660 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1232383003661 substrate binding pocket [chemical binding]; other site 1232383003662 catalytic triad [active] 1232383003663 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1232383003664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383003665 putative substrate translocation pore; other site 1232383003666 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1232383003667 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383003668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383003669 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1232383003670 putative substrate translocation pore; other site 1232383003671 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1232383003672 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1232383003673 THF binding site; other site 1232383003674 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1232383003675 substrate binding site [chemical binding]; other site 1232383003676 THF binding site; other site 1232383003677 zinc-binding site [ion binding]; other site 1232383003678 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1232383003679 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1232383003680 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1232383003681 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1232383003682 active site 1232383003683 nucleophile elbow; other site 1232383003684 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1232383003685 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1232383003686 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1232383003687 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232383003688 Q-loop/lid; other site 1232383003689 ABC transporter signature motif; other site 1232383003690 Walker B; other site 1232383003691 D-loop; other site 1232383003692 H-loop/switch region; other site 1232383003693 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1232383003694 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1232383003695 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1232383003696 Walker A/P-loop; other site 1232383003697 ATP binding site [chemical binding]; other site 1232383003698 Q-loop/lid; other site 1232383003699 ABC transporter signature motif; other site 1232383003700 Walker B; other site 1232383003701 D-loop; other site 1232383003702 H-loop/switch region; other site 1232383003703 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1232383003704 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1232383003705 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1232383003706 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 1232383003707 PLD-like domain; Region: PLDc_2; pfam13091 1232383003708 putative homodimer interface [polypeptide binding]; other site 1232383003709 putative active site [active] 1232383003710 catalytic site [active] 1232383003711 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1232383003712 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1232383003713 ATP binding site [chemical binding]; other site 1232383003714 putative Mg++ binding site [ion binding]; other site 1232383003715 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1232383003716 nucleotide binding region [chemical binding]; other site 1232383003717 ATP-binding site [chemical binding]; other site 1232383003718 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1232383003719 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1232383003720 active site 1232383003721 8-oxo-dGMP binding site [chemical binding]; other site 1232383003722 nudix motif; other site 1232383003723 metal binding site [ion binding]; metal-binding site 1232383003724 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1232383003725 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1232383003726 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1232383003727 ATP binding site [chemical binding]; other site 1232383003728 Mg++ binding site [ion binding]; other site 1232383003729 motif III; other site 1232383003730 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1232383003731 nucleotide binding region [chemical binding]; other site 1232383003732 ATP-binding site [chemical binding]; other site 1232383003733 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1232383003734 putative RNA binding site [nucleotide binding]; other site 1232383003735 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232383003736 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232383003737 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 1232383003738 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1232383003739 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1232383003740 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 1232383003741 active site 1232383003742 dimer interface [polypeptide binding]; other site 1232383003743 metal binding site [ion binding]; metal-binding site 1232383003744 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1232383003745 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 1232383003746 active site 1232383003747 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1232383003748 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1232383003749 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1232383003750 Na binding site [ion binding]; other site 1232383003751 SNF2 Helicase protein; Region: DUF3670; pfam12419 1232383003752 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1232383003753 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1232383003754 putative Mg++ binding site [ion binding]; other site 1232383003755 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1232383003756 nucleotide binding region [chemical binding]; other site 1232383003757 ATP-binding site [chemical binding]; other site 1232383003758 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1232383003759 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1232383003760 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1232383003761 active site 1232383003762 metal binding site [ion binding]; metal-binding site 1232383003763 DNA binding site [nucleotide binding] 1232383003764 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1232383003765 AAA domain; Region: AAA_27; pfam13514 1232383003766 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1232383003767 Short chain fatty acid transporter; Region: SCFA_trans; cl17380 1232383003768 Short chain fatty acid transporter; Region: SCFA_trans; cl17380 1232383003769 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1232383003770 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1232383003771 MarR family; Region: MarR_2; pfam12802 1232383003772 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 1232383003773 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1232383003774 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1232383003775 ligand binding site [chemical binding]; other site 1232383003776 flexible hinge region; other site 1232383003777 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1232383003778 non-specific DNA interactions [nucleotide binding]; other site 1232383003779 DNA binding site [nucleotide binding] 1232383003780 sequence specific DNA binding site [nucleotide binding]; other site 1232383003781 putative cAMP binding site [chemical binding]; other site 1232383003782 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1232383003783 metal-binding site [ion binding] 1232383003784 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1232383003785 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1232383003786 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232383003787 motif II; other site 1232383003788 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1232383003789 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1232383003790 synthetase active site [active] 1232383003791 NTP binding site [chemical binding]; other site 1232383003792 metal binding site [ion binding]; metal-binding site 1232383003793 TAP-like protein; Region: Abhydrolase_4; pfam08386 1232383003794 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1232383003795 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1232383003796 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1232383003797 active site 1232383003798 HIGH motif; other site 1232383003799 KMSK motif region; other site 1232383003800 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1232383003801 tRNA binding surface [nucleotide binding]; other site 1232383003802 anticodon binding site; other site 1232383003803 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1232383003804 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1232383003805 active site 1232383003806 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1232383003807 substrate binding site [chemical binding]; other site 1232383003808 catalytic residues [active] 1232383003809 dimer interface [polypeptide binding]; other site 1232383003810 homoserine dehydrogenase; Provisional; Region: PRK06349 1232383003811 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1232383003812 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1232383003813 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1232383003814 homoserine kinase; Provisional; Region: PRK01212 1232383003815 Predicted transcriptional regulator [Transcription]; Region: COG2345 1232383003816 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1232383003817 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1232383003818 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1232383003819 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1232383003820 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1232383003821 [4Fe-4S] binding site [ion binding]; other site 1232383003822 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1232383003823 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1232383003824 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1232383003825 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1232383003826 molybdopterin cofactor binding site; other site 1232383003827 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1232383003828 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1232383003829 MPT binding site; other site 1232383003830 trimer interface [polypeptide binding]; other site 1232383003831 potential frameshift: common BLAST hit: gi|19552416|ref|NP_600418.1| serine protease 1232383003832 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1232383003833 Domain of unknown function DUF21; Region: DUF21; pfam01595 1232383003834 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1232383003835 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1232383003836 Domain of unknown function DUF21; Region: DUF21; pfam01595 1232383003837 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1232383003838 Transporter associated domain; Region: CorC_HlyC; pfam03471 1232383003839 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1232383003840 GTP binding site; other site 1232383003841 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1232383003842 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1232383003843 dimer interface [polypeptide binding]; other site 1232383003844 putative functional site; other site 1232383003845 putative MPT binding site; other site 1232383003846 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1232383003847 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1232383003848 FeS/SAM binding site; other site 1232383003849 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1232383003850 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620 1232383003851 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1232383003852 dimer interface [polypeptide binding]; other site 1232383003853 acyl-activating enzyme (AAE) consensus motif; other site 1232383003854 putative active site [active] 1232383003855 AMP binding site [chemical binding]; other site 1232383003856 putative CoA binding site [chemical binding]; other site 1232383003857 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1232383003858 transcription termination factor Rho; Provisional; Region: PRK12608 1232383003859 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1232383003860 RNA binding site [nucleotide binding]; other site 1232383003861 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1232383003862 multimer interface [polypeptide binding]; other site 1232383003863 Walker A motif; other site 1232383003864 ATP binding site [chemical binding]; other site 1232383003865 Walker B motif; other site 1232383003866 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1232383003867 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1232383003868 RF-1 domain; Region: RF-1; pfam00472 1232383003869 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1232383003870 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232383003871 S-adenosylmethionine binding site [chemical binding]; other site 1232383003872 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1232383003873 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1232383003874 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1232383003875 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1232383003876 Mg++ binding site [ion binding]; other site 1232383003877 putative catalytic motif [active] 1232383003878 substrate binding site [chemical binding]; other site 1232383003879 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1232383003880 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1232383003881 F0F1 ATP synthase subunit C; Validated; Region: PRK07874 1232383003882 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1232383003883 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1232383003884 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1232383003885 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1232383003886 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1232383003887 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1232383003888 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1232383003889 beta subunit interaction interface [polypeptide binding]; other site 1232383003890 Walker A motif; other site 1232383003891 ATP binding site [chemical binding]; other site 1232383003892 Walker B motif; other site 1232383003893 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1232383003894 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1232383003895 core domain interface [polypeptide binding]; other site 1232383003896 delta subunit interface [polypeptide binding]; other site 1232383003897 epsilon subunit interface [polypeptide binding]; other site 1232383003898 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1232383003899 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1232383003900 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1232383003901 alpha subunit interaction interface [polypeptide binding]; other site 1232383003902 Walker A motif; other site 1232383003903 ATP binding site [chemical binding]; other site 1232383003904 Walker B motif; other site 1232383003905 inhibitor binding site; inhibition site 1232383003906 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1232383003907 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1232383003908 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1232383003909 gamma subunit interface [polypeptide binding]; other site 1232383003910 epsilon subunit interface [polypeptide binding]; other site 1232383003911 LBP interface [polypeptide binding]; other site 1232383003912 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1232383003913 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1232383003914 hypothetical protein; Provisional; Region: PRK03298 1232383003915 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1232383003916 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1232383003917 dimer interface [polypeptide binding]; other site 1232383003918 substrate binding site [chemical binding]; other site 1232383003919 metal binding site [ion binding]; metal-binding site 1232383003920 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1232383003921 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1232383003922 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1232383003923 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1232383003924 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1232383003925 dimer interface [polypeptide binding]; other site 1232383003926 active site 1232383003927 non-prolyl cis peptide bond; other site 1232383003928 insertion regions; other site 1232383003929 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1232383003930 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232383003931 dimer interface [polypeptide binding]; other site 1232383003932 conserved gate region; other site 1232383003933 putative PBP binding loops; other site 1232383003934 ABC-ATPase subunit interface; other site 1232383003935 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1232383003936 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1232383003937 Walker A/P-loop; other site 1232383003938 ATP binding site [chemical binding]; other site 1232383003939 Q-loop/lid; other site 1232383003940 ABC transporter signature motif; other site 1232383003941 Walker B; other site 1232383003942 D-loop; other site 1232383003943 H-loop/switch region; other site 1232383003944 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1232383003945 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1232383003946 substrate binding pocket [chemical binding]; other site 1232383003947 membrane-bound complex binding site; other site 1232383003948 hinge residues; other site 1232383003949 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 1232383003950 glycogen branching enzyme; Provisional; Region: PRK05402 1232383003951 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1232383003952 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1232383003953 active site 1232383003954 catalytic site [active] 1232383003955 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1232383003956 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1232383003957 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1232383003958 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1232383003959 active site 1232383003960 catalytic site [active] 1232383003961 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 1232383003962 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232383003963 Walker A/P-loop; other site 1232383003964 ATP binding site [chemical binding]; other site 1232383003965 Q-loop/lid; other site 1232383003966 ABC transporter signature motif; other site 1232383003967 Walker B; other site 1232383003968 D-loop; other site 1232383003969 H-loop/switch region; other site 1232383003970 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1232383003971 Ligand binding site [chemical binding]; other site 1232383003972 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1232383003973 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1232383003974 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1232383003975 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1232383003976 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1232383003977 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1232383003978 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1232383003979 catalytic residue [active] 1232383003980 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 1232383003981 HipA N-terminal domain; Region: couple_hipA; TIGR03071 1232383003982 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1232383003983 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1232383003984 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1232383003985 salt bridge; other site 1232383003986 non-specific DNA binding site [nucleotide binding]; other site 1232383003987 sequence-specific DNA binding site [nucleotide binding]; other site 1232383003988 Predicted acetyltransferase [General function prediction only]; Region: COG3153 1232383003989 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232383003990 S-adenosylmethionine binding site [chemical binding]; other site 1232383003991 AAA ATPase domain; Region: AAA_16; pfam13191 1232383003992 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1232383003993 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1232383003994 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1232383003995 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1232383003996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383003997 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1232383003998 putative substrate translocation pore; other site 1232383003999 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383004000 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1232383004001 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1232383004002 active site 1232383004003 catalytic site [active] 1232383004004 substrate binding site [chemical binding]; other site 1232383004005 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1232383004006 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1232383004007 nucleotide binding pocket [chemical binding]; other site 1232383004008 K-X-D-G motif; other site 1232383004009 catalytic site [active] 1232383004010 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1232383004011 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1232383004012 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1232383004013 Dimer interface [polypeptide binding]; other site 1232383004014 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1232383004015 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1232383004016 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1232383004017 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1232383004018 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1232383004019 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1232383004020 FAD binding pocket [chemical binding]; other site 1232383004021 FAD binding motif [chemical binding]; other site 1232383004022 phosphate binding motif [ion binding]; other site 1232383004023 NAD binding pocket [chemical binding]; other site 1232383004024 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1232383004025 phosphofructokinase; Region: PFK_mixed; TIGR02483 1232383004026 active site 1232383004027 ADP/pyrophosphate binding site [chemical binding]; other site 1232383004028 dimerization interface [polypeptide binding]; other site 1232383004029 allosteric effector site; other site 1232383004030 fructose-1,6-bisphosphate binding site; other site 1232383004031 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1232383004032 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1232383004033 DNA binding site [nucleotide binding] 1232383004034 domain linker motif; other site 1232383004035 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 1232383004036 dimerization interface [polypeptide binding]; other site 1232383004037 putative ligand binding site [chemical binding]; other site 1232383004038 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1232383004039 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1232383004040 Walker A/P-loop; other site 1232383004041 ATP binding site [chemical binding]; other site 1232383004042 Q-loop/lid; other site 1232383004043 ABC transporter signature motif; other site 1232383004044 Walker B; other site 1232383004045 D-loop; other site 1232383004046 H-loop/switch region; other site 1232383004047 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1232383004048 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1232383004049 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1232383004050 TM-ABC transporter signature motif; other site 1232383004051 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1232383004052 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1232383004053 ligand binding site [chemical binding]; other site 1232383004054 dimerization interface [polypeptide binding]; other site 1232383004055 D-ribose pyranase; Provisional; Region: PRK11797 1232383004056 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1232383004057 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1232383004058 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1232383004059 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1232383004060 siderophore binding site; other site 1232383004061 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1232383004062 Sodium Bile acid symporter family; Region: SBF; pfam01758 1232383004063 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1232383004064 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1232383004065 GatB domain; Region: GatB_Yqey; pfam02637 1232383004066 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1232383004067 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1232383004068 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1232383004069 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1232383004070 active site 1232383004071 catalytic tetrad [active] 1232383004072 L-lysine exporter; Region: 2a75; TIGR00948 1232383004073 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1232383004074 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1232383004075 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1232383004076 dimerization interface [polypeptide binding]; other site 1232383004077 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1232383004078 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1232383004079 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1232383004080 putative dimer interface [polypeptide binding]; other site 1232383004081 N-terminal domain interface [polypeptide binding]; other site 1232383004082 putative substrate binding pocket (H-site) [chemical binding]; other site 1232383004083 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1232383004084 Predicted membrane protein [Function unknown]; Region: COG2259 1232383004085 hypothetical protein; Validated; Region: PRK09039 1232383004086 Integrase core domain; Region: rve; pfam00665 1232383004087 Integrase core domain; Region: rve_3; pfam13683 1232383004088 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1232383004089 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1232383004090 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1232383004091 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1232383004092 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1232383004093 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1232383004094 PYR/PP interface [polypeptide binding]; other site 1232383004095 dimer interface [polypeptide binding]; other site 1232383004096 TPP binding site [chemical binding]; other site 1232383004097 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1232383004098 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1232383004099 TPP-binding site [chemical binding]; other site 1232383004100 dimer interface [polypeptide binding]; other site 1232383004101 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1232383004102 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1232383004103 putative valine binding site [chemical binding]; other site 1232383004104 dimer interface [polypeptide binding]; other site 1232383004105 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1232383004106 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1232383004107 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1232383004108 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1232383004109 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232383004110 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1232383004111 ABC transporter signature motif; other site 1232383004112 Walker B; other site 1232383004113 D-loop; other site 1232383004114 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1232383004115 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232383004116 Walker A/P-loop; other site 1232383004117 ATP binding site [chemical binding]; other site 1232383004118 Q-loop/lid; other site 1232383004119 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1232383004120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232383004121 dimer interface [polypeptide binding]; other site 1232383004122 conserved gate region; other site 1232383004123 putative PBP binding loops; other site 1232383004124 ABC-ATPase subunit interface; other site 1232383004125 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1232383004126 NMT1-like family; Region: NMT1_2; pfam13379 1232383004127 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232383004128 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1232383004129 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1232383004130 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1232383004131 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1232383004132 Protein of unknown function DUF262; Region: DUF262; pfam03235 1232383004133 Uncharacterized conserved protein [Function unknown]; Region: COG3472 1232383004134 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1232383004135 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1232383004136 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1232383004137 ligand binding site [chemical binding]; other site 1232383004138 NAD binding site [chemical binding]; other site 1232383004139 dimerization interface [polypeptide binding]; other site 1232383004140 catalytic site [active] 1232383004141 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1232383004142 putative L-serine binding site [chemical binding]; other site 1232383004143 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1232383004144 tartrate dehydrogenase; Region: TTC; TIGR02089 1232383004145 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1232383004146 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1232383004147 substrate binding pocket [chemical binding]; other site 1232383004148 membrane-bound complex binding site; other site 1232383004149 hinge residues; other site 1232383004150 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 1232383004151 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1232383004152 ligand binding site [chemical binding]; other site 1232383004153 flexible hinge region; other site 1232383004154 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 1232383004155 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1232383004156 metal binding triad; other site 1232383004157 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1232383004158 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1232383004159 active site 1232383004160 catalytic site [active] 1232383004161 substrate binding site [chemical binding]; other site 1232383004162 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1232383004163 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1232383004164 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1232383004165 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1232383004166 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232383004167 S-adenosylmethionine binding site [chemical binding]; other site 1232383004168 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1232383004169 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1232383004170 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1232383004171 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1232383004172 active site 1232383004173 HIGH motif; other site 1232383004174 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1232383004175 active site 1232383004176 KMSKS motif; other site 1232383004177 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1232383004178 salt bridge; other site 1232383004179 non-specific DNA binding site [nucleotide binding]; other site 1232383004180 sequence-specific DNA binding site [nucleotide binding]; other site 1232383004181 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 1232383004182 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 1232383004183 putative hydrophobic ligand binding site [chemical binding]; other site 1232383004184 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232383004185 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232383004186 WHG domain; Region: WHG; pfam13305 1232383004187 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 1232383004188 putative hydrophobic ligand binding site [chemical binding]; other site 1232383004189 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1232383004190 ThiC-associated domain; Region: ThiC-associated; pfam13667 1232383004191 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1232383004192 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1232383004193 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1232383004194 homodimer interface [polypeptide binding]; other site 1232383004195 active site pocket [active] 1232383004196 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1232383004197 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1232383004198 active site residue [active] 1232383004199 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1232383004200 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1232383004201 HD domain; Region: HD_4; pfam13328 1232383004202 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1232383004203 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1232383004204 Bacterial transcriptional regulator; Region: IclR; pfam01614 1232383004205 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1232383004206 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1232383004207 substrate binding site [chemical binding]; other site 1232383004208 ligand binding site [chemical binding]; other site 1232383004209 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1232383004210 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1232383004211 substrate binding site [chemical binding]; other site 1232383004212 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1232383004213 active site 1232383004214 Ap6A binding site [chemical binding]; other site 1232383004215 nudix motif; other site 1232383004216 metal binding site [ion binding]; metal-binding site 1232383004217 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1232383004218 catalytic core [active] 1232383004219 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1232383004220 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1232383004221 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1232383004222 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1232383004223 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1232383004224 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1232383004225 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1232383004226 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1232383004227 thiamine monophosphate kinase; Provisional; Region: PRK05731 1232383004228 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1232383004229 ATP binding site [chemical binding]; other site 1232383004230 dimerization interface [polypeptide binding]; other site 1232383004231 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1232383004232 ligand binding site [chemical binding]; other site 1232383004233 active site 1232383004234 UGI interface [polypeptide binding]; other site 1232383004235 catalytic site [active] 1232383004236 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 1232383004237 DAK2 domain; Region: Dak2; pfam02734 1232383004238 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 1232383004239 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1232383004240 generic binding surface II; other site 1232383004241 ssDNA binding site; other site 1232383004242 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1232383004243 ATP binding site [chemical binding]; other site 1232383004244 putative Mg++ binding site [ion binding]; other site 1232383004245 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1232383004246 nucleotide binding region [chemical binding]; other site 1232383004247 ATP-binding site [chemical binding]; other site 1232383004248 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 1232383004249 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1232383004250 carboxyltransferase (CT) interaction site; other site 1232383004251 biotinylation site [posttranslational modification]; other site 1232383004252 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1232383004253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232383004254 S-adenosylmethionine binding site [chemical binding]; other site 1232383004255 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1232383004256 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1232383004257 active site 1232383004258 (T/H)XGH motif; other site 1232383004259 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1232383004260 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1232383004261 Walker A/P-loop; other site 1232383004262 ATP binding site [chemical binding]; other site 1232383004263 Q-loop/lid; other site 1232383004264 ABC transporter signature motif; other site 1232383004265 Walker B; other site 1232383004266 D-loop; other site 1232383004267 H-loop/switch region; other site 1232383004268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232383004269 dimer interface [polypeptide binding]; other site 1232383004270 conserved gate region; other site 1232383004271 putative PBP binding loops; other site 1232383004272 ABC-ATPase subunit interface; other site 1232383004273 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1232383004274 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1232383004275 substrate binding pocket [chemical binding]; other site 1232383004276 membrane-bound complex binding site; other site 1232383004277 hinge residues; other site 1232383004278 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 1232383004279 Domain of unknown function (DUF368); Region: DUF368; pfam04018 1232383004280 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1232383004281 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1232383004282 active site 1232383004283 DNA binding site [nucleotide binding] 1232383004284 Int/Topo IB signature motif; other site 1232383004285 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1232383004286 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4815 1232383004287 putative transposase OrfB; Reviewed; Region: PHA02517 1232383004288 HTH-like domain; Region: HTH_21; pfam13276 1232383004289 Integrase core domain; Region: rve; pfam00665 1232383004290 Integrase core domain; Region: rve_3; pfam13683 1232383004291 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1232383004292 Transposase; Region: HTH_Tnp_1; pfam01527 1232383004293 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 1232383004294 Uncharacterized conserved small protein [Function unknown]; Region: COG5428 1232383004295 Integrase core domain; Region: rve_3; cl15866 1232383004296 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1232383004297 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 1232383004298 DNA polymerase I; Provisional; Region: PRK05755 1232383004299 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1232383004300 active site 1232383004301 metal binding site 1 [ion binding]; metal-binding site 1232383004302 putative 5' ssDNA interaction site; other site 1232383004303 metal binding site 3; metal-binding site 1232383004304 metal binding site 2 [ion binding]; metal-binding site 1232383004305 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1232383004306 putative DNA binding site [nucleotide binding]; other site 1232383004307 putative metal binding site [ion binding]; other site 1232383004308 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1232383004309 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1232383004310 active site 1232383004311 DNA binding site [nucleotide binding] 1232383004312 catalytic site [active] 1232383004313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383004314 Helix-turn-helix domain; Region: HTH_31; pfam13560 1232383004315 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1232383004316 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1232383004317 active site 1232383004318 catalytic tetrad [active] 1232383004319 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 1232383004320 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232383004321 S-adenosylmethionine binding site [chemical binding]; other site 1232383004322 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1232383004323 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1232383004324 RNA binding site [nucleotide binding]; other site 1232383004325 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1232383004326 RNA binding site [nucleotide binding]; other site 1232383004327 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1232383004328 RNA binding site [nucleotide binding]; other site 1232383004329 S1 RNA binding domain; Region: S1; pfam00575 1232383004330 RNA binding site [nucleotide binding]; other site 1232383004331 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1232383004332 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1232383004333 active site turn [active] 1232383004334 phosphorylation site [posttranslational modification] 1232383004335 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1232383004336 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1232383004337 HPr interaction site; other site 1232383004338 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1232383004339 active site 1232383004340 phosphorylation site [posttranslational modification] 1232383004341 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1232383004342 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1232383004343 CoA-binding site [chemical binding]; other site 1232383004344 ATP-binding [chemical binding]; other site 1232383004345 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 1232383004346 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1232383004347 active site 1232383004348 catalytic site [active] 1232383004349 substrate binding site [chemical binding]; other site 1232383004350 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 1232383004351 Dimer interface [polypeptide binding]; other site 1232383004352 BRCT sequence motif; other site 1232383004353 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 1232383004354 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1232383004355 heme-binding site [chemical binding]; other site 1232383004356 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1232383004357 active site 1232383004358 tetramer interface [polypeptide binding]; other site 1232383004359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383004360 putative substrate translocation pore; other site 1232383004361 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1232383004362 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1232383004363 substrate binding site [chemical binding]; other site 1232383004364 dimer interface [polypeptide binding]; other site 1232383004365 ATP binding site [chemical binding]; other site 1232383004366 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1232383004367 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1232383004368 DNA binding site [nucleotide binding] 1232383004369 domain linker motif; other site 1232383004370 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 1232383004371 dimerization interface [polypeptide binding]; other site 1232383004372 putative ligand binding site [chemical binding]; other site 1232383004373 excinuclease ABC subunit B; Provisional; Region: PRK05298 1232383004374 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1232383004375 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1232383004376 nucleotide binding region [chemical binding]; other site 1232383004377 ATP-binding site [chemical binding]; other site 1232383004378 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1232383004379 UvrB/uvrC motif; Region: UVR; pfam02151 1232383004380 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1232383004381 Ligand Binding Site [chemical binding]; other site 1232383004382 Predicted transcriptional regulators [Transcription]; Region: COG1733 1232383004383 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1232383004384 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1232383004385 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1232383004386 NADP binding site [chemical binding]; other site 1232383004387 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1232383004388 Part of AAA domain; Region: AAA_19; pfam13245 1232383004389 Family description; Region: UvrD_C_2; pfam13538 1232383004390 Predicted membrane protein [Function unknown]; Region: COG2259 1232383004391 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1232383004392 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1232383004393 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1232383004394 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1232383004395 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1232383004396 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 1232383004397 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1232383004398 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1232383004399 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1232383004400 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1232383004401 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1232383004402 23S rRNA binding site [nucleotide binding]; other site 1232383004403 L21 binding site [polypeptide binding]; other site 1232383004404 L13 binding site [polypeptide binding]; other site 1232383004405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232383004406 dimer interface [polypeptide binding]; other site 1232383004407 conserved gate region; other site 1232383004408 putative PBP binding loops; other site 1232383004409 ABC-ATPase subunit interface; other site 1232383004410 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1232383004411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232383004412 dimer interface [polypeptide binding]; other site 1232383004413 conserved gate region; other site 1232383004414 putative PBP binding loops; other site 1232383004415 ABC-ATPase subunit interface; other site 1232383004416 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1232383004417 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1232383004418 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1232383004419 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1232383004420 Walker A/P-loop; other site 1232383004421 ATP binding site [chemical binding]; other site 1232383004422 Q-loop/lid; other site 1232383004423 ABC transporter signature motif; other site 1232383004424 Walker B; other site 1232383004425 D-loop; other site 1232383004426 H-loop/switch region; other site 1232383004427 TOBE domain; Region: TOBE_2; pfam08402 1232383004428 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1232383004429 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 1232383004430 active site 1232383004431 catalytic site [active] 1232383004432 metal binding site [ion binding]; metal-binding site 1232383004433 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1232383004434 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1232383004435 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1232383004436 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1232383004437 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1232383004438 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1232383004439 dimer interface [polypeptide binding]; other site 1232383004440 motif 1; other site 1232383004441 active site 1232383004442 motif 2; other site 1232383004443 motif 3; other site 1232383004444 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1232383004445 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1232383004446 putative tRNA-binding site [nucleotide binding]; other site 1232383004447 B3/4 domain; Region: B3_4; pfam03483 1232383004448 tRNA synthetase B5 domain; Region: B5; smart00874 1232383004449 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1232383004450 dimer interface [polypeptide binding]; other site 1232383004451 motif 1; other site 1232383004452 motif 3; other site 1232383004453 motif 2; other site 1232383004454 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1232383004455 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1232383004456 active site 1232383004457 catalytic triad [active] 1232383004458 oxyanion hole [active] 1232383004459 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1232383004460 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1232383004461 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1232383004462 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1232383004463 heterotetramer interface [polypeptide binding]; other site 1232383004464 active site pocket [active] 1232383004465 cleavage site 1232383004466 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1232383004467 feedback inhibition sensing region; other site 1232383004468 homohexameric interface [polypeptide binding]; other site 1232383004469 nucleotide binding site [chemical binding]; other site 1232383004470 N-acetyl-L-glutamate binding site [chemical binding]; other site 1232383004471 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1232383004472 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1232383004473 inhibitor-cofactor binding pocket; inhibition site 1232383004474 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232383004475 catalytic residue [active] 1232383004476 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1232383004477 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1232383004478 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1232383004479 arginine repressor; Provisional; Region: PRK03341 1232383004480 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1232383004481 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1232383004482 argininosuccinate synthase; Provisional; Region: PRK13820 1232383004483 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1232383004484 ANP binding site [chemical binding]; other site 1232383004485 Substrate Binding Site II [chemical binding]; other site 1232383004486 Substrate Binding Site I [chemical binding]; other site 1232383004487 argininosuccinate lyase; Provisional; Region: PRK00855 1232383004488 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1232383004489 active sites [active] 1232383004490 tetramer interface [polypeptide binding]; other site 1232383004491 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1232383004492 metal ion-dependent adhesion site (MIDAS); other site 1232383004493 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1232383004494 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1232383004495 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1232383004496 active site 1232383004497 HIGH motif; other site 1232383004498 dimer interface [polypeptide binding]; other site 1232383004499 KMSKS motif; other site 1232383004500 S4 RNA-binding domain; Region: S4; smart00363 1232383004501 RNA binding surface [nucleotide binding]; other site 1232383004502 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1232383004503 Ligand Binding Site [chemical binding]; other site 1232383004504 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1232383004505 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1232383004506 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232383004507 active site 1232383004508 motif I; other site 1232383004509 motif II; other site 1232383004510 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232383004511 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1232383004512 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1232383004513 RNA binding surface [nucleotide binding]; other site 1232383004514 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232383004515 S-adenosylmethionine binding site [chemical binding]; other site 1232383004516 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1232383004517 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1232383004518 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1232383004519 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1232383004520 Walker A/P-loop; other site 1232383004521 ATP binding site [chemical binding]; other site 1232383004522 Q-loop/lid; other site 1232383004523 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1232383004524 ABC transporter signature motif; other site 1232383004525 Walker B; other site 1232383004526 D-loop; other site 1232383004527 H-loop/switch region; other site 1232383004528 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1232383004529 Thiamine pyrophosphokinase; Region: TPK; cl08415 1232383004530 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1232383004531 CTP synthetase; Validated; Region: pyrG; PRK05380 1232383004532 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1232383004533 Catalytic site [active] 1232383004534 active site 1232383004535 UTP binding site [chemical binding]; other site 1232383004536 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1232383004537 active site 1232383004538 putative oxyanion hole; other site 1232383004539 catalytic triad [active] 1232383004540 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1232383004541 dimer interface [polypeptide binding]; other site 1232383004542 ADP-ribose binding site [chemical binding]; other site 1232383004543 active site 1232383004544 nudix motif; other site 1232383004545 metal binding site [ion binding]; metal-binding site 1232383004546 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1232383004547 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1232383004548 active site 1232383004549 Int/Topo IB signature motif; other site 1232383004550 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1232383004551 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232383004552 Walker A/P-loop; other site 1232383004553 ATP binding site [chemical binding]; other site 1232383004554 Q-loop/lid; other site 1232383004555 ABC transporter signature motif; other site 1232383004556 Walker B; other site 1232383004557 D-loop; other site 1232383004558 H-loop/switch region; other site 1232383004559 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1232383004560 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1232383004561 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1232383004562 P-loop; other site 1232383004563 Magnesium ion binding site [ion binding]; other site 1232383004564 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1232383004565 Magnesium ion binding site [ion binding]; other site 1232383004566 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1232383004567 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1232383004568 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1232383004569 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1232383004570 active site residue [active] 1232383004571 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1232383004572 active site residue [active] 1232383004573 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1232383004574 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1232383004575 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1232383004576 RNA binding surface [nucleotide binding]; other site 1232383004577 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1232383004578 active site 1232383004579 cytidylate kinase; Provisional; Region: cmk; PRK00023 1232383004580 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1232383004581 CMP-binding site; other site 1232383004582 The sites determining sugar specificity; other site 1232383004583 GTP-binding protein Der; Reviewed; Region: PRK03003 1232383004584 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1232383004585 G1 box; other site 1232383004586 GTP/Mg2+ binding site [chemical binding]; other site 1232383004587 Switch I region; other site 1232383004588 G2 box; other site 1232383004589 Switch II region; other site 1232383004590 G3 box; other site 1232383004591 G4 box; other site 1232383004592 G5 box; other site 1232383004593 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1232383004594 G1 box; other site 1232383004595 GTP/Mg2+ binding site [chemical binding]; other site 1232383004596 Switch I region; other site 1232383004597 G2 box; other site 1232383004598 G3 box; other site 1232383004599 Switch II region; other site 1232383004600 G4 box; other site 1232383004601 G5 box; other site 1232383004602 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1232383004603 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1232383004604 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1232383004605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232383004606 S-adenosylmethionine binding site [chemical binding]; other site 1232383004607 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1232383004608 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1232383004609 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232383004610 Walker B; other site 1232383004611 D-loop; other site 1232383004612 H-loop/switch region; other site 1232383004613 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1232383004614 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1232383004615 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232383004616 Walker A/P-loop; other site 1232383004617 ATP binding site [chemical binding]; other site 1232383004618 Q-loop/lid; other site 1232383004619 ABC transporter signature motif; other site 1232383004620 Walker B; other site 1232383004621 D-loop; other site 1232383004622 H-loop/switch region; other site 1232383004623 zinc transporter ZupT; Provisional; Region: PRK04201 1232383004624 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1232383004625 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 1232383004626 SEC-C motif; Region: SEC-C; pfam02810 1232383004627 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1232383004628 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1232383004629 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 1232383004630 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1232383004631 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1232383004632 nucleotide binding region [chemical binding]; other site 1232383004633 ATP-binding site [chemical binding]; other site 1232383004634 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1232383004635 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1232383004636 phosphopeptide binding site; other site 1232383004637 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1232383004638 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1232383004639 DNA binding residues [nucleotide binding] 1232383004640 Uncharacterized conserved protein [Function unknown]; Region: COG1259 1232383004641 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1232383004642 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1232383004643 DNA binding residues [nucleotide binding] 1232383004644 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1232383004645 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1232383004646 Domain of unknown function DUF21; Region: DUF21; pfam01595 1232383004647 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1232383004648 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1232383004649 Domain of unknown function DUF21; Region: DUF21; pfam01595 1232383004650 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1232383004651 Transporter associated domain; Region: CorC_HlyC; smart01091 1232383004652 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1232383004653 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1232383004654 ATP binding site [chemical binding]; other site 1232383004655 putative Mg++ binding site [ion binding]; other site 1232383004656 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1232383004657 nucleotide binding region [chemical binding]; other site 1232383004658 ATP-binding site [chemical binding]; other site 1232383004659 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1232383004660 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1232383004661 FAD binding pocket [chemical binding]; other site 1232383004662 FAD binding motif [chemical binding]; other site 1232383004663 phosphate binding motif [ion binding]; other site 1232383004664 NAD binding pocket [chemical binding]; other site 1232383004665 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1232383004666 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1232383004667 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1232383004668 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1232383004669 CoenzymeA binding site [chemical binding]; other site 1232383004670 subunit interaction site [polypeptide binding]; other site 1232383004671 PHB binding site; other site 1232383004672 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1232383004673 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232383004674 S-adenosylmethionine binding site [chemical binding]; other site 1232383004675 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1232383004676 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1232383004677 Walker A/P-loop; other site 1232383004678 ATP binding site [chemical binding]; other site 1232383004679 Q-loop/lid; other site 1232383004680 ABC transporter signature motif; other site 1232383004681 Walker B; other site 1232383004682 D-loop; other site 1232383004683 H-loop/switch region; other site 1232383004684 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1232383004685 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1232383004686 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1232383004687 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1232383004688 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1232383004689 putative active site [active] 1232383004690 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1232383004691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232383004692 dimer interface [polypeptide binding]; other site 1232383004693 conserved gate region; other site 1232383004694 ABC-ATPase subunit interface; other site 1232383004695 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1232383004696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232383004697 dimer interface [polypeptide binding]; other site 1232383004698 conserved gate region; other site 1232383004699 ABC-ATPase subunit interface; other site 1232383004700 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1232383004701 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1232383004702 Walker A/P-loop; other site 1232383004703 ATP binding site [chemical binding]; other site 1232383004704 Q-loop/lid; other site 1232383004705 ABC transporter signature motif; other site 1232383004706 Walker B; other site 1232383004707 D-loop; other site 1232383004708 H-loop/switch region; other site 1232383004709 potential frameshift: common BLAST hit: gi|62390344|ref|YP_225746.1| alkylphosphonate ABC transporter phosphate-binding protein 1232383004710 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1232383004711 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1232383004712 motif I; other site 1232383004713 active site 1232383004714 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1232383004715 motif II; other site 1232383004716 multifunctional thiamine-phosphate pyrophosphorylase/synthase/phosphomethylpyrimidine kinase; Provisional; Region: PRK09517 1232383004717 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1232383004718 thiamine phosphate binding site [chemical binding]; other site 1232383004719 active site 1232383004720 pyrophosphate binding site [ion binding]; other site 1232383004721 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1232383004722 dimer interface [polypeptide binding]; other site 1232383004723 substrate binding site [chemical binding]; other site 1232383004724 ATP binding site [chemical binding]; other site 1232383004725 Putative transcription activator [Transcription]; Region: TenA; COG0819 1232383004726 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1232383004727 substrate binding site [chemical binding]; other site 1232383004728 multimerization interface [polypeptide binding]; other site 1232383004729 ATP binding site [chemical binding]; other site 1232383004730 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1232383004731 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1232383004732 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232383004733 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1232383004734 metabolite-proton symporter; Region: 2A0106; TIGR00883 1232383004735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383004736 putative substrate translocation pore; other site 1232383004737 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 1232383004738 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1232383004739 active site 1232383004740 Predicted membrane protein [Function unknown]; Region: COG1971 1232383004741 Domain of unknown function DUF; Region: DUF204; pfam02659 1232383004742 Domain of unknown function DUF; Region: DUF204; pfam02659 1232383004743 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1232383004744 Sodium Bile acid symporter family; Region: SBF; cl17470 1232383004745 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1232383004746 A new structural DNA glycosylase; Region: AlkD_like; cd06561 1232383004747 active site 1232383004748 high affinity sulphate transporter 1; Region: sulP; TIGR00815 1232383004749 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1232383004750 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1232383004751 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1232383004752 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1232383004753 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1232383004754 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1232383004755 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1232383004756 Ligand binding site; other site 1232383004757 Putative Catalytic site; other site 1232383004758 DXD motif; other site 1232383004759 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1232383004760 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1232383004761 putative active site [active] 1232383004762 catalytic triad [active] 1232383004763 putative dimer interface [polypeptide binding]; other site 1232383004764 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1232383004765 Secretory lipase; Region: LIP; pfam03583 1232383004766 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1232383004767 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1232383004768 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1232383004769 active site 1232383004770 putative homodimer interface [polypeptide binding]; other site 1232383004771 SAM binding site [chemical binding]; other site 1232383004772 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1232383004773 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1232383004774 AAA domain; Region: AAA_13; pfam13166 1232383004775 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232383004776 ABC transporter signature motif; other site 1232383004777 Walker B; other site 1232383004778 D-loop; other site 1232383004779 H-loop/switch region; other site 1232383004780 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1232383004781 classical (c) SDRs; Region: SDR_c; cd05233 1232383004782 NAD(P) binding site [chemical binding]; other site 1232383004783 active site 1232383004784 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1232383004785 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1232383004786 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1232383004787 active site 1232383004788 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1232383004789 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1232383004790 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1232383004791 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1232383004792 ATP binding site [chemical binding]; other site 1232383004793 putative Mg++ binding site [ion binding]; other site 1232383004794 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1232383004795 nucleotide binding region [chemical binding]; other site 1232383004796 ATP-binding site [chemical binding]; other site 1232383004797 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1232383004798 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1232383004799 twin arginine translocase protein A; Provisional; Region: tatA; PRK00191 1232383004800 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1232383004801 Predicted transcriptional regulator [Transcription]; Region: COG2378 1232383004802 WYL domain; Region: WYL; pfam13280 1232383004803 Predicted transcriptional regulator [Transcription]; Region: COG2378 1232383004804 WYL domain; Region: WYL; pfam13280 1232383004805 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 1232383004806 Pup-like protein; Region: Pup; pfam05639 1232383004807 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 1232383004808 proteasome ATPase; Region: pup_AAA; TIGR03689 1232383004809 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232383004810 Walker A motif; other site 1232383004811 ATP binding site [chemical binding]; other site 1232383004812 Walker B motif; other site 1232383004813 arginine finger; other site 1232383004814 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1232383004815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232383004816 S-adenosylmethionine binding site [chemical binding]; other site 1232383004817 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1232383004818 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1232383004819 active site 1232383004820 metal binding site [ion binding]; metal-binding site 1232383004821 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1232383004822 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1232383004823 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1232383004824 non-specific DNA binding site [nucleotide binding]; other site 1232383004825 salt bridge; other site 1232383004826 sequence-specific DNA binding site [nucleotide binding]; other site 1232383004827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383004828 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1232383004829 putative substrate translocation pore; other site 1232383004830 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1232383004831 Aspartase; Region: Aspartase; cd01357 1232383004832 active sites [active] 1232383004833 tetramer interface [polypeptide binding]; other site 1232383004834 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1232383004835 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1232383004836 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1232383004837 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1232383004838 homodimer interface [polypeptide binding]; other site 1232383004839 putative metal binding site [ion binding]; other site 1232383004840 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1232383004841 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232383004842 motif II; other site 1232383004843 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1232383004844 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 1232383004845 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1232383004846 substrate binding pocket [chemical binding]; other site 1232383004847 dimer interface [polypeptide binding]; other site 1232383004848 inhibitor binding site; inhibition site 1232383004849 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1232383004850 B12 binding site [chemical binding]; other site 1232383004851 cobalt ligand [ion binding]; other site 1232383004852 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1232383004853 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1232383004854 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1232383004855 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1232383004856 dimerization interface [polypeptide binding]; other site 1232383004857 putative DNA binding site [nucleotide binding]; other site 1232383004858 putative Zn2+ binding site [ion binding]; other site 1232383004859 arsenical-resistance protein; Region: acr3; TIGR00832 1232383004860 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1232383004861 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1232383004862 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1232383004863 active site 1232383004864 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1232383004865 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1232383004866 active site 1232383004867 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 1232383004868 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1232383004869 active site 1232383004870 HIGH motif; other site 1232383004871 nucleotide binding site [chemical binding]; other site 1232383004872 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1232383004873 active site 1232383004874 KMSKS motif; other site 1232383004875 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1232383004876 tRNA binding surface [nucleotide binding]; other site 1232383004877 anticodon binding site; other site 1232383004878 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 1232383004879 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1232383004880 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1232383004881 active site 1232383004882 catalytic tetrad [active] 1232383004883 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1232383004884 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1232383004885 quinone interaction residues [chemical binding]; other site 1232383004886 active site 1232383004887 catalytic residues [active] 1232383004888 FMN binding site [chemical binding]; other site 1232383004889 substrate binding site [chemical binding]; other site 1232383004890 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1232383004891 substrate binding site [chemical binding]; other site 1232383004892 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1232383004893 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232383004894 Walker A/P-loop; other site 1232383004895 ATP binding site [chemical binding]; other site 1232383004896 Q-loop/lid; other site 1232383004897 ABC transporter signature motif; other site 1232383004898 Walker B; other site 1232383004899 D-loop; other site 1232383004900 H-loop/switch region; other site 1232383004901 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 1232383004902 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1232383004903 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232383004904 Q-loop/lid; other site 1232383004905 ABC transporter signature motif; other site 1232383004906 Walker B; other site 1232383004907 D-loop; other site 1232383004908 H-loop/switch region; other site 1232383004909 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1232383004910 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1232383004911 Coenzyme A binding pocket [chemical binding]; other site 1232383004912 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1232383004913 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1232383004914 Walker A; other site 1232383004915 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1232383004916 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1232383004917 active site 1232383004918 substrate binding site [chemical binding]; other site 1232383004919 coenzyme B12 binding site [chemical binding]; other site 1232383004920 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1232383004921 B12 binding site [chemical binding]; other site 1232383004922 cobalt ligand [ion binding]; other site 1232383004923 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1232383004924 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1232383004925 heterodimer interface [polypeptide binding]; other site 1232383004926 substrate interaction site [chemical binding]; other site 1232383004927 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Region: Sbm; COG2185 1232383004928 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1232383004929 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1232383004930 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1232383004931 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1232383004932 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1232383004933 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1232383004934 ferrochelatase; Reviewed; Region: hemH; PRK00035 1232383004935 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1232383004936 C-terminal domain interface [polypeptide binding]; other site 1232383004937 active site 1232383004938 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1232383004939 active site 1232383004940 N-terminal domain interface [polypeptide binding]; other site 1232383004941 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1232383004942 NlpC/P60 family; Region: NLPC_P60; pfam00877 1232383004943 aconitate hydratase; Validated; Region: PRK09277 1232383004944 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1232383004945 substrate binding site [chemical binding]; other site 1232383004946 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1232383004947 ligand binding site [chemical binding]; other site 1232383004948 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1232383004949 substrate binding site [chemical binding]; other site 1232383004950 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232383004951 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232383004952 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1232383004953 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1232383004954 catalytic triad [active] 1232383004955 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232383004956 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1232383004957 NAD(P) binding site [chemical binding]; other site 1232383004958 active site 1232383004959 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 1232383004960 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 1232383004961 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1232383004962 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1232383004963 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1232383004964 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1232383004965 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232383004966 motif II; other site 1232383004967 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1232383004968 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4762 1232383004969 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1232383004970 metal binding triad [ion binding]; metal-binding site 1232383004971 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1232383004972 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1232383004973 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232383004974 Walker A/P-loop; other site 1232383004975 ATP binding site [chemical binding]; other site 1232383004976 Q-loop/lid; other site 1232383004977 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1232383004978 ABC transporter signature motif; other site 1232383004979 Walker B; other site 1232383004980 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1232383004981 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 1232383004982 catalytic site [active] 1232383004983 BNR repeat-like domain; Region: BNR_2; pfam13088 1232383004984 Asp-box motif; other site 1232383004985 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 1232383004986 Arrestin (or S-antigen), C-terminal domain; Region: Arrestin_C; cl02844 1232383004987 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1232383004988 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1232383004989 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1232383004990 trimerization site [polypeptide binding]; other site 1232383004991 active site 1232383004992 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1232383004993 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1232383004994 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1232383004995 catalytic residue [active] 1232383004996 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1232383004997 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1232383004998 Walker A/P-loop; other site 1232383004999 ATP binding site [chemical binding]; other site 1232383005000 Q-loop/lid; other site 1232383005001 ABC transporter signature motif; other site 1232383005002 Walker B; other site 1232383005003 D-loop; other site 1232383005004 H-loop/switch region; other site 1232383005005 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1232383005006 FeS assembly protein SufD; Region: sufD; TIGR01981 1232383005007 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1232383005008 FeS assembly protein SufB; Region: sufB; TIGR01980 1232383005009 Predicted transcriptional regulator [Transcription]; Region: COG2345 1232383005010 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1232383005011 putative DNA binding site [nucleotide binding]; other site 1232383005012 putative Zn2+ binding site [ion binding]; other site 1232383005013 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1232383005014 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1232383005015 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1232383005016 Walker A/P-loop; other site 1232383005017 ATP binding site [chemical binding]; other site 1232383005018 Q-loop/lid; other site 1232383005019 ABC transporter signature motif; other site 1232383005020 Walker B; other site 1232383005021 D-loop; other site 1232383005022 H-loop/switch region; other site 1232383005023 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1232383005024 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1232383005025 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1232383005026 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1232383005027 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4951 1232383005028 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1232383005029 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1232383005030 ATP binding site [chemical binding]; other site 1232383005031 putative Mg++ binding site [ion binding]; other site 1232383005032 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1232383005033 nucleotide binding region [chemical binding]; other site 1232383005034 ATP-binding site [chemical binding]; other site 1232383005035 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1232383005036 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1232383005037 NADP binding site [chemical binding]; other site 1232383005038 dimer interface [polypeptide binding]; other site 1232383005039 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1232383005040 UbiA prenyltransferase family; Region: UbiA; pfam01040 1232383005041 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1232383005042 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1232383005043 TPP-binding site [chemical binding]; other site 1232383005044 dimer interface [polypeptide binding]; other site 1232383005045 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1232383005046 PYR/PP interface [polypeptide binding]; other site 1232383005047 dimer interface [polypeptide binding]; other site 1232383005048 TPP binding site [chemical binding]; other site 1232383005049 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1232383005050 putative active site [active] 1232383005051 transaldolase; Provisional; Region: PRK03903 1232383005052 catalytic residue [active] 1232383005053 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1232383005054 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1232383005055 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1232383005056 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1232383005057 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 1232383005058 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1232383005059 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1232383005060 putative active site [active] 1232383005061 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1232383005062 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1232383005063 ornithine cyclodeaminase; Validated; Region: PRK06199 1232383005064 Ornithine cyclodeaminase/mu-crystallin family; Region: OCD_Mu_crystall; pfam02423 1232383005065 ammonium transporter; Region: amt; TIGR00836 1232383005066 Preprotein translocase SecG subunit; Region: SecG; cl09123 1232383005067 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1232383005068 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1232383005069 triosephosphate isomerase; Provisional; Region: PRK14567 1232383005070 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1232383005071 substrate binding site [chemical binding]; other site 1232383005072 dimer interface [polypeptide binding]; other site 1232383005073 catalytic triad [active] 1232383005074 Phosphoglycerate kinase; Region: PGK; pfam00162 1232383005075 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1232383005076 substrate binding site [chemical binding]; other site 1232383005077 hinge regions; other site 1232383005078 ADP binding site [chemical binding]; other site 1232383005079 catalytic site [active] 1232383005080 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1232383005081 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1232383005082 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1232383005083 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1232383005084 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1232383005085 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1232383005086 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1232383005087 phosphate binding site [ion binding]; other site 1232383005088 putative substrate binding pocket [chemical binding]; other site 1232383005089 dimer interface [polypeptide binding]; other site 1232383005090 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 1232383005091 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1232383005092 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1232383005093 GIY-YIG motif/motif A; other site 1232383005094 active site 1232383005095 catalytic site [active] 1232383005096 putative DNA binding site [nucleotide binding]; other site 1232383005097 metal binding site [ion binding]; metal-binding site 1232383005098 UvrB/uvrC motif; Region: UVR; pfam02151 1232383005099 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1232383005100 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1232383005101 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1232383005102 homopentamer interface [polypeptide binding]; other site 1232383005103 active site 1232383005104 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1232383005105 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1232383005106 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1232383005107 dimerization interface [polypeptide binding]; other site 1232383005108 active site 1232383005109 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1232383005110 Lumazine binding domain; Region: Lum_binding; pfam00677 1232383005111 Lumazine binding domain; Region: Lum_binding; pfam00677 1232383005112 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1232383005113 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1232383005114 catalytic motif [active] 1232383005115 Zn binding site [ion binding]; other site 1232383005116 RibD C-terminal domain; Region: RibD_C; pfam01872 1232383005117 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1232383005118 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1232383005119 substrate binding site [chemical binding]; other site 1232383005120 hexamer interface [polypeptide binding]; other site 1232383005121 metal binding site [ion binding]; metal-binding site 1232383005122 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1232383005123 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1232383005124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232383005125 S-adenosylmethionine binding site [chemical binding]; other site 1232383005126 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1232383005127 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1232383005128 putative active site [active] 1232383005129 substrate binding site [chemical binding]; other site 1232383005130 putative cosubstrate binding site; other site 1232383005131 catalytic site [active] 1232383005132 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1232383005133 substrate binding site [chemical binding]; other site 1232383005134 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1232383005135 active site 1232383005136 catalytic residues [active] 1232383005137 metal binding site [ion binding]; metal-binding site 1232383005138 primosome assembly protein PriA; Provisional; Region: PRK14873 1232383005139 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1232383005140 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1232383005141 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1232383005142 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1232383005143 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1232383005144 Flavoprotein; Region: Flavoprotein; pfam02441 1232383005145 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1232383005146 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1232383005147 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1232383005148 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1232383005149 catalytic site [active] 1232383005150 G-X2-G-X-G-K; other site 1232383005151 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1232383005152 active site 1232383005153 dimer interface [polypeptide binding]; other site 1232383005154 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1232383005155 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1232383005156 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1232383005157 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1232383005158 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1232383005159 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1232383005160 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1232383005161 IMP binding site; other site 1232383005162 dimer interface [polypeptide binding]; other site 1232383005163 interdomain contacts; other site 1232383005164 partial ornithine binding site; other site 1232383005165 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1232383005166 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1232383005167 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1232383005168 catalytic site [active] 1232383005169 subunit interface [polypeptide binding]; other site 1232383005170 dihydroorotase; Validated; Region: pyrC; PRK09357 1232383005171 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1232383005172 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1232383005173 active site 1232383005174 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1232383005175 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1232383005176 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1232383005177 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1232383005178 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1232383005179 active site 1232383005180 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 1232383005181 putative hydrophobic ligand binding site [chemical binding]; other site 1232383005182 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1232383005183 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1232383005184 putative NAD(P) binding site [chemical binding]; other site 1232383005185 putative active site [active] 1232383005186 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1232383005187 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1232383005188 Transcription termination factor [Transcription]; Region: NusB; COG0781 1232383005189 putative RNA binding site [nucleotide binding]; other site 1232383005190 elongation factor P; Validated; Region: PRK00529 1232383005191 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1232383005192 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1232383005193 RNA binding site [nucleotide binding]; other site 1232383005194 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1232383005195 RNA binding site [nucleotide binding]; other site 1232383005196 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1232383005197 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1232383005198 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1232383005199 active site 1232383005200 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1232383005201 active site 1232383005202 dimer interface [polypeptide binding]; other site 1232383005203 metal binding site [ion binding]; metal-binding site 1232383005204 shikimate kinase; Reviewed; Region: aroK; PRK00131 1232383005205 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1232383005206 ADP binding site [chemical binding]; other site 1232383005207 magnesium binding site [ion binding]; other site 1232383005208 putative shikimate binding site; other site 1232383005209 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1232383005210 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1232383005211 Tetramer interface [polypeptide binding]; other site 1232383005212 active site 1232383005213 FMN-binding site [chemical binding]; other site 1232383005214 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1232383005215 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1232383005216 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1232383005217 dimerization interface [polypeptide binding]; other site 1232383005218 putative DNA binding site [nucleotide binding]; other site 1232383005219 putative Zn2+ binding site [ion binding]; other site 1232383005220 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1232383005221 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1232383005222 ABC-ATPase subunit interface; other site 1232383005223 dimer interface [polypeptide binding]; other site 1232383005224 putative PBP binding regions; other site 1232383005225 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1232383005226 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 1232383005227 putative ligand binding residues [chemical binding]; other site 1232383005228 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1232383005229 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1232383005230 Walker A/P-loop; other site 1232383005231 ATP binding site [chemical binding]; other site 1232383005232 Q-loop/lid; other site 1232383005233 ABC transporter signature motif; other site 1232383005234 Walker B; other site 1232383005235 D-loop; other site 1232383005236 H-loop/switch region; other site 1232383005237 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1232383005238 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1232383005239 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1232383005240 shikimate binding site; other site 1232383005241 NAD(P) binding site [chemical binding]; other site 1232383005242 YceG-like family; Region: YceG; pfam02618 1232383005243 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1232383005244 dimerization interface [polypeptide binding]; other site 1232383005245 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1232383005246 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1232383005247 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1232383005248 motif 1; other site 1232383005249 active site 1232383005250 motif 2; other site 1232383005251 motif 3; other site 1232383005252 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1232383005253 recombination factor protein RarA; Reviewed; Region: PRK13342 1232383005254 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232383005255 Walker A motif; other site 1232383005256 ATP binding site [chemical binding]; other site 1232383005257 Walker B motif; other site 1232383005258 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1232383005259 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1232383005260 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1232383005261 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1232383005262 dimer interface [polypeptide binding]; other site 1232383005263 anticodon binding site; other site 1232383005264 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1232383005265 homodimer interface [polypeptide binding]; other site 1232383005266 motif 1; other site 1232383005267 active site 1232383005268 motif 2; other site 1232383005269 GAD domain; Region: GAD; pfam02938 1232383005270 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1232383005271 active site 1232383005272 motif 3; other site 1232383005273 Predicted metalloprotease [General function prediction only]; Region: COG2321 1232383005274 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1232383005275 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1232383005276 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1232383005277 ATP binding site [chemical binding]; other site 1232383005278 putative Mg++ binding site [ion binding]; other site 1232383005279 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1232383005280 nucleotide binding region [chemical binding]; other site 1232383005281 ATP-binding site [chemical binding]; other site 1232383005282 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1232383005283 Predicted membrane protein [Function unknown]; Region: COG1511 1232383005284 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1232383005285 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1232383005286 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1232383005287 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232383005288 Q-loop/lid; other site 1232383005289 ABC transporter signature motif; other site 1232383005290 Walker B; other site 1232383005291 D-loop; other site 1232383005292 H-loop/switch region; other site 1232383005293 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232383005294 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232383005295 Predicted transcriptional regulator with C-terminal CBS domains [Transcription]; Region: COG3620 1232383005296 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1232383005297 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232383005298 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1232383005299 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1232383005300 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 1232383005301 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1232383005302 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1232383005303 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1232383005304 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1232383005305 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1232383005306 dimer interface [polypeptide binding]; other site 1232383005307 motif 1; other site 1232383005308 active site 1232383005309 motif 2; other site 1232383005310 motif 3; other site 1232383005311 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1232383005312 anticodon binding site; other site 1232383005313 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1232383005314 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1232383005315 active site 1232383005316 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1232383005317 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1232383005318 Zn2+ binding site [ion binding]; other site 1232383005319 Mg2+ binding site [ion binding]; other site 1232383005320 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1232383005321 synthetase active site [active] 1232383005322 NTP binding site [chemical binding]; other site 1232383005323 metal binding site [ion binding]; metal-binding site 1232383005324 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1232383005325 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1232383005326 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1232383005327 active site 1232383005328 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1232383005329 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1232383005330 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1232383005331 Protein export membrane protein; Region: SecD_SecF; cl14618 1232383005332 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 1232383005333 Protein export membrane protein; Region: SecD_SecF; cl14618 1232383005334 Preprotein translocase subunit; Region: YajC; pfam02699 1232383005335 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1232383005336 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232383005337 Walker A motif; other site 1232383005338 ATP binding site [chemical binding]; other site 1232383005339 Walker B motif; other site 1232383005340 arginine finger; other site 1232383005341 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1232383005342 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632 1232383005343 RuvA N terminal domain; Region: RuvA_N; pfam01330 1232383005344 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1232383005345 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1232383005346 active site 1232383005347 putative DNA-binding cleft [nucleotide binding]; other site 1232383005348 dimer interface [polypeptide binding]; other site 1232383005349 hypothetical protein; Validated; Region: PRK00110 1232383005350 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1232383005351 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1232383005352 active site 1232383005353 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1232383005354 catalytic triad [active] 1232383005355 dimer interface [polypeptide binding]; other site 1232383005356 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1232383005357 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1232383005358 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1232383005359 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1232383005360 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1232383005361 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1232383005362 putative acyl-acceptor binding pocket; other site 1232383005363 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1232383005364 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1232383005365 nucleotide binding site/active site [active] 1232383005366 HIT family signature motif; other site 1232383005367 catalytic residue [active] 1232383005368 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1232383005369 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1232383005370 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1232383005371 active site 1232383005372 dimer interface [polypeptide binding]; other site 1232383005373 motif 1; other site 1232383005374 motif 2; other site 1232383005375 motif 3; other site 1232383005376 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1232383005377 anticodon binding site; other site 1232383005378 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1232383005379 Copper(I)-binding protein [Inorganic ion transport and metabolism]; Region: COG2847 1232383005380 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 1232383005381 Integrase core domain; Region: rve; pfam00665 1232383005382 Integrase core domain; Region: rve_3; pfam13683 1232383005383 hypothetical protein; Validated; Region: PRK09039 1232383005384 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1232383005385 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1232383005386 transmembrane helices; other site 1232383005387 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1232383005388 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1232383005389 tartrate dehydrogenase; Region: TTC; TIGR02089 1232383005390 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1232383005391 hypothetical protein; Provisional; Region: PRK14059 1232383005392 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1232383005393 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1232383005394 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1232383005395 SelR domain; Region: SelR; pfam01641 1232383005396 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1232383005397 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1232383005398 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1232383005399 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1232383005400 catalytic site [active] 1232383005401 putative active site [active] 1232383005402 putative substrate binding site [chemical binding]; other site 1232383005403 HRDC domain; Region: HRDC; pfam00570 1232383005404 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 1232383005405 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1232383005406 TPP-binding site; other site 1232383005407 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1232383005408 PYR/PP interface [polypeptide binding]; other site 1232383005409 dimer interface [polypeptide binding]; other site 1232383005410 TPP binding site [chemical binding]; other site 1232383005411 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1232383005412 TRAM domain; Region: TRAM; pfam01938 1232383005413 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1232383005414 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1232383005415 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1232383005416 trimer interface [polypeptide binding]; other site 1232383005417 active site 1232383005418 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1232383005419 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1232383005420 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1232383005421 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1232383005422 active site 1232383005423 dimerization interface [polypeptide binding]; other site 1232383005424 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1232383005425 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1232383005426 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1232383005427 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1232383005428 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1232383005429 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1232383005430 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1232383005431 DNA binding residues [nucleotide binding] 1232383005432 Predicted membrane protein [Function unknown]; Region: COG2311 1232383005433 Protein of unknown function (DUF418); Region: DUF418; cl12135 1232383005434 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1232383005435 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1232383005436 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1232383005437 ATP binding site [chemical binding]; other site 1232383005438 putative Mg++ binding site [ion binding]; other site 1232383005439 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1232383005440 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1232383005441 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1232383005442 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232383005443 S-adenosylmethionine binding site [chemical binding]; other site 1232383005444 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1232383005445 putative active site [active] 1232383005446 dimerization interface [polypeptide binding]; other site 1232383005447 putative tRNAtyr binding site [nucleotide binding]; other site 1232383005448 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1232383005449 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1232383005450 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1232383005451 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1232383005452 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1232383005453 DNA binding residues [nucleotide binding] 1232383005454 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1232383005455 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1232383005456 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1232383005457 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1232383005458 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1232383005459 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1232383005460 NAD binding site [chemical binding]; other site 1232383005461 homodimer interface [polypeptide binding]; other site 1232383005462 active site 1232383005463 substrate binding site [chemical binding]; other site 1232383005464 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1232383005465 PAC2 family; Region: PAC2; pfam09754 1232383005466 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1232383005467 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1232383005468 ATP binding site [chemical binding]; other site 1232383005469 putative Mg++ binding site [ion binding]; other site 1232383005470 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1232383005471 nucleotide binding region [chemical binding]; other site 1232383005472 ATP-binding site [chemical binding]; other site 1232383005473 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 1232383005474 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1232383005475 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1232383005476 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1232383005477 dimerization interface [polypeptide binding]; other site 1232383005478 Predicted integral membrane protein [Function unknown]; Region: COG5473 1232383005479 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1232383005480 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1232383005481 ATP binding site [chemical binding]; other site 1232383005482 putative Mg++ binding site [ion binding]; other site 1232383005483 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1232383005484 nucleotide binding region [chemical binding]; other site 1232383005485 ATP-binding site [chemical binding]; other site 1232383005486 Helicase associated domain (HA2); Region: HA2; pfam04408 1232383005487 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1232383005488 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1232383005489 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1232383005490 ATP cone domain; Region: ATP-cone; pfam03477 1232383005491 LexA repressor; Validated; Region: PRK00215 1232383005492 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1232383005493 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1232383005494 Catalytic site [active] 1232383005495 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1232383005496 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1232383005497 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1232383005498 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1232383005499 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1232383005500 substrate binding site [chemical binding]; other site 1232383005501 ATP binding site [chemical binding]; other site 1232383005502 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1232383005503 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1232383005504 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1232383005505 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1232383005506 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1232383005507 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1232383005508 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1232383005509 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1232383005510 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1232383005511 putative substrate binding site [chemical binding]; other site 1232383005512 putative ATP binding site [chemical binding]; other site 1232383005513 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1232383005514 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1232383005515 active site 1232383005516 phosphorylation site [posttranslational modification] 1232383005517 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1232383005518 active site 1232383005519 P-loop; other site 1232383005520 phosphorylation site [posttranslational modification] 1232383005521 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1232383005522 Phosphotransferase System HPr (HPr) Family; Region: PTS_HPr_family; TIGR01003 1232383005523 dimerization domain swap beta strand [polypeptide binding]; other site 1232383005524 regulatory protein interface [polypeptide binding]; other site 1232383005525 active site 1232383005526 regulatory phosphorylation site [posttranslational modification]; other site 1232383005527 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1232383005528 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1232383005529 GTPases [General function prediction only]; Region: HflX; COG2262 1232383005530 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1232383005531 HflX GTPase family; Region: HflX; cd01878 1232383005532 G1 box; other site 1232383005533 GTP/Mg2+ binding site [chemical binding]; other site 1232383005534 Switch I region; other site 1232383005535 G2 box; other site 1232383005536 G3 box; other site 1232383005537 Switch II region; other site 1232383005538 G4 box; other site 1232383005539 G5 box; other site 1232383005540 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1232383005541 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1232383005542 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1232383005543 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1232383005544 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1232383005545 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1232383005546 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1232383005547 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1232383005548 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1232383005549 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1232383005550 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1232383005551 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1232383005552 FeS/SAM binding site; other site 1232383005553 TRAM domain; Region: TRAM; cl01282 1232383005554 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1232383005555 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1232383005556 Walker A/P-loop; other site 1232383005557 ATP binding site [chemical binding]; other site 1232383005558 Q-loop/lid; other site 1232383005559 ABC transporter signature motif; other site 1232383005560 Walker B; other site 1232383005561 D-loop; other site 1232383005562 H-loop/switch region; other site 1232383005563 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1232383005564 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1232383005565 substrate binding pocket [chemical binding]; other site 1232383005566 membrane-bound complex binding site; other site 1232383005567 hinge residues; other site 1232383005568 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1232383005569 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232383005570 dimer interface [polypeptide binding]; other site 1232383005571 conserved gate region; other site 1232383005572 putative PBP binding loops; other site 1232383005573 ABC-ATPase subunit interface; other site 1232383005574 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1232383005575 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232383005576 dimer interface [polypeptide binding]; other site 1232383005577 conserved gate region; other site 1232383005578 putative PBP binding loops; other site 1232383005579 ABC-ATPase subunit interface; other site 1232383005580 Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137 1232383005581 recombinase A; Provisional; Region: recA; PRK09354 1232383005582 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1232383005583 hexamer interface [polypeptide binding]; other site 1232383005584 Walker A motif; other site 1232383005585 ATP binding site [chemical binding]; other site 1232383005586 Walker B motif; other site 1232383005587 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1232383005588 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 1232383005589 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1232383005590 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1232383005591 Walker A/P-loop; other site 1232383005592 ATP binding site [chemical binding]; other site 1232383005593 Q-loop/lid; other site 1232383005594 ABC transporter signature motif; other site 1232383005595 Walker B; other site 1232383005596 D-loop; other site 1232383005597 H-loop/switch region; other site 1232383005598 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1232383005599 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1232383005600 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1232383005601 non-specific DNA binding site [nucleotide binding]; other site 1232383005602 salt bridge; other site 1232383005603 sequence-specific DNA binding site [nucleotide binding]; other site 1232383005604 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1232383005605 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1232383005606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 1232383005607 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1232383005608 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1232383005609 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1232383005610 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1232383005611 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1232383005612 TIGR03085 family protein; Region: TIGR03085 1232383005613 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1232383005614 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1232383005615 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1232383005616 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1232383005617 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1232383005618 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1232383005619 dimer interface [polypeptide binding]; other site 1232383005620 active site 1232383005621 catalytic residue [active] 1232383005622 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1232383005623 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1232383005624 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1232383005625 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1232383005626 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1232383005627 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1232383005628 oligomer interface [polypeptide binding]; other site 1232383005629 RNA binding site [nucleotide binding]; other site 1232383005630 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1232383005631 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1232383005632 RNase E interface [polypeptide binding]; other site 1232383005633 trimer interface [polypeptide binding]; other site 1232383005634 active site 1232383005635 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1232383005636 putative nucleic acid binding region [nucleotide binding]; other site 1232383005637 G-X-X-G motif; other site 1232383005638 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1232383005639 RNA binding site [nucleotide binding]; other site 1232383005640 domain interface; other site 1232383005641 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1232383005642 16S/18S rRNA binding site [nucleotide binding]; other site 1232383005643 S13e-L30e interaction site [polypeptide binding]; other site 1232383005644 25S rRNA binding site [nucleotide binding]; other site 1232383005645 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 1232383005646 active site 1232383005647 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1232383005648 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1232383005649 Riboflavin kinase; Region: Flavokinase; smart00904 1232383005650 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1232383005651 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1232383005652 RNA binding site [nucleotide binding]; other site 1232383005653 active site 1232383005654 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1232383005655 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1232383005656 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1232383005657 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1232383005658 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1232383005659 active site 1232383005660 metal binding site [ion binding]; metal-binding site 1232383005661 putative phosphoesterase; Region: acc_ester; TIGR03729 1232383005662 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1232383005663 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1232383005664 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1232383005665 DHH family; Region: DHH; pfam01368 1232383005666 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1232383005667 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1232383005668 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1232383005669 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1232383005670 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1232383005671 G1 box; other site 1232383005672 putative GEF interaction site [polypeptide binding]; other site 1232383005673 GTP/Mg2+ binding site [chemical binding]; other site 1232383005674 Switch I region; other site 1232383005675 G2 box; other site 1232383005676 G3 box; other site 1232383005677 Switch II region; other site 1232383005678 G4 box; other site 1232383005679 G5 box; other site 1232383005680 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1232383005681 Translation-initiation factor 2; Region: IF-2; pfam11987 1232383005682 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1232383005683 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 1232383005684 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1232383005685 NusA N-terminal domain; Region: NusA_N; pfam08529 1232383005686 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1232383005687 RNA binding site [nucleotide binding]; other site 1232383005688 homodimer interface [polypeptide binding]; other site 1232383005689 NusA-like KH domain; Region: KH_5; pfam13184 1232383005690 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1232383005691 G-X-X-G motif; other site 1232383005692 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1232383005693 Sm and related proteins; Region: Sm_like; cl00259 1232383005694 Sm and related proteins; Region: Sm_like; cl00259 1232383005695 heptamer interface [polypeptide binding]; other site 1232383005696 Sm1 motif; other site 1232383005697 hexamer interface [polypeptide binding]; other site 1232383005698 RNA binding site [nucleotide binding]; other site 1232383005699 Sm2 motif; other site 1232383005700 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1232383005701 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1232383005702 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1232383005703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232383005704 dimer interface [polypeptide binding]; other site 1232383005705 conserved gate region; other site 1232383005706 ABC-ATPase subunit interface; other site 1232383005707 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1232383005708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232383005709 dimer interface [polypeptide binding]; other site 1232383005710 conserved gate region; other site 1232383005711 putative PBP binding loops; other site 1232383005712 ABC-ATPase subunit interface; other site 1232383005713 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1232383005714 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1232383005715 Walker A/P-loop; other site 1232383005716 ATP binding site [chemical binding]; other site 1232383005717 Q-loop/lid; other site 1232383005718 ABC transporter signature motif; other site 1232383005719 Walker B; other site 1232383005720 D-loop; other site 1232383005721 H-loop/switch region; other site 1232383005722 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1232383005723 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1232383005724 Walker A/P-loop; other site 1232383005725 ATP binding site [chemical binding]; other site 1232383005726 Q-loop/lid; other site 1232383005727 ABC transporter signature motif; other site 1232383005728 Walker B; other site 1232383005729 D-loop; other site 1232383005730 H-loop/switch region; other site 1232383005731 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1232383005732 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1232383005733 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1232383005734 dimer interface [polypeptide binding]; other site 1232383005735 motif 1; other site 1232383005736 active site 1232383005737 motif 2; other site 1232383005738 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1232383005739 putative deacylase active site [active] 1232383005740 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1232383005741 active site 1232383005742 motif 3; other site 1232383005743 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1232383005744 anticodon binding site; other site 1232383005745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3022 1232383005746 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 1232383005747 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1232383005748 metal ion-dependent adhesion site (MIDAS); other site 1232383005749 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 1232383005750 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232383005751 Walker A motif; other site 1232383005752 ATP binding site [chemical binding]; other site 1232383005753 Walker B motif; other site 1232383005754 arginine finger; other site 1232383005755 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1232383005756 diphthine synthase; Region: dph5; TIGR00522 1232383005757 active site 1232383005758 SAM binding site [chemical binding]; other site 1232383005759 homodimer interface [polypeptide binding]; other site 1232383005760 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1232383005761 hypothetical protein; Validated; Region: PRK00029 1232383005762 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1232383005763 dimer interface [polypeptide binding]; other site 1232383005764 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1232383005765 dimer interface [polypeptide binding]; other site 1232383005766 malate:quinone oxidoreductase; Validated; Region: PRK05257 1232383005767 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1232383005768 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1232383005769 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1232383005770 mycothione reductase; Region: mycothione_red; TIGR03452 1232383005771 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232383005772 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1232383005773 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1232383005774 active site 1232383005775 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1232383005776 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1232383005777 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1232383005778 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1232383005779 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1232383005780 active site 1232383005781 phosphorylation site [posttranslational modification] 1232383005782 intermolecular recognition site; other site 1232383005783 dimerization interface [polypeptide binding]; other site 1232383005784 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1232383005785 DNA binding residues [nucleotide binding] 1232383005786 dimerization interface [polypeptide binding]; other site 1232383005787 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1232383005788 Histidine kinase; Region: HisKA_3; pfam07730 1232383005789 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1232383005790 Mg2+ binding site [ion binding]; other site 1232383005791 G-X-G motif; other site 1232383005792 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1232383005793 FtsX-like permease family; Region: FtsX; pfam02687 1232383005794 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1232383005795 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1232383005796 Walker A/P-loop; other site 1232383005797 ATP binding site [chemical binding]; other site 1232383005798 Q-loop/lid; other site 1232383005799 ABC transporter signature motif; other site 1232383005800 Walker B; other site 1232383005801 D-loop; other site 1232383005802 H-loop/switch region; other site 1232383005803 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1232383005804 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1232383005805 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1232383005806 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1232383005807 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1232383005808 active site 1232383005809 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1232383005810 protein binding site [polypeptide binding]; other site 1232383005811 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1232383005812 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1232383005813 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1232383005814 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1232383005815 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 1232383005816 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1232383005817 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1232383005818 Walker A/P-loop; other site 1232383005819 ATP binding site [chemical binding]; other site 1232383005820 Q-loop/lid; other site 1232383005821 ABC transporter signature motif; other site 1232383005822 Walker B; other site 1232383005823 D-loop; other site 1232383005824 H-loop/switch region; other site 1232383005825 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1232383005826 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1232383005827 FeS/SAM binding site; other site 1232383005828 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1232383005829 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1232383005830 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1232383005831 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1232383005832 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1232383005833 hinge region; other site 1232383005834 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1232383005835 putative nucleotide binding site [chemical binding]; other site 1232383005836 uridine monophosphate binding site [chemical binding]; other site 1232383005837 homohexameric interface [polypeptide binding]; other site 1232383005838 elongation factor Ts; Provisional; Region: tsf; PRK09377 1232383005839 UBA/TS-N domain; Region: UBA; pfam00627 1232383005840 Elongation factor TS; Region: EF_TS; pfam00889 1232383005841 Elongation factor TS; Region: EF_TS; pfam00889 1232383005842 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1232383005843 rRNA interaction site [nucleotide binding]; other site 1232383005844 S8 interaction site; other site 1232383005845 putative laminin-1 binding site; other site 1232383005846 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1232383005847 Peptidase family M23; Region: Peptidase_M23; pfam01551 1232383005848 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1232383005849 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1232383005850 active site 1232383005851 DNA binding site [nucleotide binding] 1232383005852 Int/Topo IB signature motif; other site 1232383005853 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1232383005854 DNA protecting protein DprA; Region: dprA; TIGR00732 1232383005855 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1232383005856 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1232383005857 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1232383005858 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1232383005859 hypothetical protein; Reviewed; Region: PRK12497 1232383005860 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1232383005861 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1232383005862 RNA/DNA hybrid binding site [nucleotide binding]; other site 1232383005863 active site 1232383005864 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1232383005865 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1232383005866 Catalytic site [active] 1232383005867 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1232383005868 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1232383005869 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1232383005870 siderophore binding site; other site 1232383005871 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1232383005872 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1232383005873 active site 1232383005874 pyrophosphate binding site [ion binding]; other site 1232383005875 thiamine phosphate binding site [chemical binding]; other site 1232383005876 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1232383005877 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1232383005878 thiS-thiF/thiG interaction site; other site 1232383005879 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1232383005880 ThiS interaction site; other site 1232383005881 putative active site [active] 1232383005882 tetramer interface [polypeptide binding]; other site 1232383005883 thiamine biosynthesis protein ThiF; Validated; Region: PRK05600 1232383005884 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1232383005885 ATP binding site [chemical binding]; other site 1232383005886 substrate interface [chemical binding]; other site 1232383005887 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1232383005888 active site residue [active] 1232383005889 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1232383005890 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1232383005891 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1232383005892 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1232383005893 RNA binding site [nucleotide binding]; other site 1232383005894 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1232383005895 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1232383005896 DNA binding site [nucleotide binding] 1232383005897 domain linker motif; other site 1232383005898 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1232383005899 dimerization interface [polypeptide binding]; other site 1232383005900 ligand binding site [chemical binding]; other site 1232383005901 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1232383005902 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1232383005903 transmembrane helices; other site 1232383005904 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1232383005905 potential frameshift: common BLAST hit: gi|62390884|ref|YP_226286.1| 3-carboxy-cis,cis-muconate cycloisomerase 1232383005906 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1232383005907 Helix-turn-helix domain; Region: HTH_38; pfam13936 1232383005908 Homeodomain-like domain; Region: HTH_32; pfam13565 1232383005909 Integrase core domain; Region: rve; pfam00665 1232383005910 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1232383005911 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1232383005912 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1232383005913 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 1232383005914 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1232383005915 RimM N-terminal domain; Region: RimM; pfam01782 1232383005916 PRC-barrel domain; Region: PRC; pfam05239 1232383005917 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1232383005918 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1232383005919 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1232383005920 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1232383005921 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1232383005922 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1232383005923 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232383005924 Walker A/P-loop; other site 1232383005925 ATP binding site [chemical binding]; other site 1232383005926 Q-loop/lid; other site 1232383005927 ABC transporter signature motif; other site 1232383005928 Walker B; other site 1232383005929 D-loop; other site 1232383005930 H-loop/switch region; other site 1232383005931 signal recognition particle protein; Provisional; Region: PRK10867 1232383005932 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1232383005933 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1232383005934 P loop; other site 1232383005935 GTP binding site [chemical binding]; other site 1232383005936 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1232383005937 PII uridylyl-transferase; Provisional; Region: glnD; PRK00227 1232383005938 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1232383005939 metal binding triad; other site 1232383005940 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1232383005941 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1232383005942 Zn2+ binding site [ion binding]; other site 1232383005943 Mg2+ binding site [ion binding]; other site 1232383005944 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1232383005945 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1232383005946 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1232383005947 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1232383005948 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1232383005949 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1232383005950 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1232383005951 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1232383005952 Walker A/P-loop; other site 1232383005953 ATP binding site [chemical binding]; other site 1232383005954 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 1232383005955 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1232383005956 ABC transporter signature motif; other site 1232383005957 Walker B; other site 1232383005958 D-loop; other site 1232383005959 H-loop/switch region; other site 1232383005960 acylphosphatase; Provisional; Region: PRK14422 1232383005961 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1232383005962 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1232383005963 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1232383005964 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1232383005965 DNA binding site [nucleotide binding] 1232383005966 catalytic residue [active] 1232383005967 H2TH interface [polypeptide binding]; other site 1232383005968 putative catalytic residues [active] 1232383005969 turnover-facilitating residue; other site 1232383005970 intercalation triad [nucleotide binding]; other site 1232383005971 8OG recognition residue [nucleotide binding]; other site 1232383005972 putative reading head residues; other site 1232383005973 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1232383005974 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1232383005975 ribonuclease III; Reviewed; Region: rnc; PRK00102 1232383005976 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1232383005977 dimerization interface [polypeptide binding]; other site 1232383005978 active site 1232383005979 metal binding site [ion binding]; metal-binding site 1232383005980 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1232383005981 dsRNA binding site [nucleotide binding]; other site 1232383005982 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1232383005983 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1232383005984 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1232383005985 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1232383005986 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1232383005987 Walker A/P-loop; other site 1232383005988 ATP binding site [chemical binding]; other site 1232383005989 Q-loop/lid; other site 1232383005990 ABC transporter signature motif; other site 1232383005991 Walker B; other site 1232383005992 D-loop; other site 1232383005993 H-loop/switch region; other site 1232383005994 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1232383005995 Walker A/P-loop; other site 1232383005996 ATP binding site [chemical binding]; other site 1232383005997 ABC transporter; Region: ABC_tran; pfam00005 1232383005998 Q-loop/lid; other site 1232383005999 ABC transporter signature motif; other site 1232383006000 Walker B; other site 1232383006001 D-loop; other site 1232383006002 H-loop/switch region; other site 1232383006003 glutamate dehydrogenase; Provisional; Region: PRK09414 1232383006004 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1232383006005 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1232383006006 NAD(P) binding site [chemical binding]; other site 1232383006007 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1232383006008 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1232383006009 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1232383006010 nucleotide binding site/active site [active] 1232383006011 HIT family signature motif; other site 1232383006012 catalytic residue [active] 1232383006013 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1232383006014 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1232383006015 metal binding site [ion binding]; metal-binding site 1232383006016 putative dimer interface [polypeptide binding]; other site 1232383006017 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1232383006018 putative homodimer interface [polypeptide binding]; other site 1232383006019 putative active site pocket [active] 1232383006020 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1232383006021 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1232383006022 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1232383006023 putative metal binding site [ion binding]; other site 1232383006024 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1232383006025 active site 1232383006026 pyruvate kinase; Provisional; Region: PRK06247 1232383006027 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1232383006028 domain interfaces; other site 1232383006029 active site 1232383006030 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1232383006031 Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Region: TrpC; COG0134 1232383006032 phosphate binding site [ion binding]; other site 1232383006033 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 1232383006034 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1232383006035 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1232383006036 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1232383006037 substrate binding site [chemical binding]; other site 1232383006038 glutamase interaction surface [polypeptide binding]; other site 1232383006039 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1232383006040 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1232383006041 active site 1232383006042 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1232383006043 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1232383006044 catalytic residues [active] 1232383006045 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1232383006046 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1232383006047 putative active site [active] 1232383006048 oxyanion strand; other site 1232383006049 catalytic triad [active] 1232383006050 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383006051 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1232383006052 putative substrate translocation pore; other site 1232383006053 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1232383006054 putative active site pocket [active] 1232383006055 4-fold oligomerization interface [polypeptide binding]; other site 1232383006056 metal binding residues [ion binding]; metal-binding site 1232383006057 3-fold/trimer interface [polypeptide binding]; other site 1232383006058 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1232383006059 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1232383006060 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232383006061 homodimer interface [polypeptide binding]; other site 1232383006062 catalytic residue [active] 1232383006063 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1232383006064 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1232383006065 NAD binding site [chemical binding]; other site 1232383006066 dimerization interface [polypeptide binding]; other site 1232383006067 product binding site; other site 1232383006068 substrate binding site [chemical binding]; other site 1232383006069 zinc binding site [ion binding]; other site 1232383006070 catalytic residues [active] 1232383006071 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1232383006072 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1232383006073 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1232383006074 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232383006075 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1232383006076 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1232383006077 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1232383006078 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1232383006079 active site 1232383006080 catalytic site [active] 1232383006081 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1232383006082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232383006083 S-adenosylmethionine binding site [chemical binding]; other site 1232383006084 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1232383006085 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 1232383006086 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1232383006087 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1232383006088 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1232383006089 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1232383006090 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1232383006091 DNA binding site [nucleotide binding] 1232383006092 domain linker motif; other site 1232383006093 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1232383006094 dimerization interface [polypeptide binding]; other site 1232383006095 ligand binding site [chemical binding]; other site 1232383006096 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1232383006097 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1232383006098 Walker A/P-loop; other site 1232383006099 ATP binding site [chemical binding]; other site 1232383006100 Q-loop/lid; other site 1232383006101 ABC transporter signature motif; other site 1232383006102 Walker B; other site 1232383006103 D-loop; other site 1232383006104 H-loop/switch region; other site 1232383006105 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1232383006106 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1232383006107 ABC-ATPase subunit interface; other site 1232383006108 dimer interface [polypeptide binding]; other site 1232383006109 putative PBP binding regions; other site 1232383006110 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1232383006111 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1232383006112 putative binding site residues; other site 1232383006113 Predicted transcriptional regulators [Transcription]; Region: COG1733 1232383006114 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1232383006115 dimerization interface [polypeptide binding]; other site 1232383006116 putative DNA binding site [nucleotide binding]; other site 1232383006117 putative Zn2+ binding site [ion binding]; other site 1232383006118 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1232383006119 active site 1232383006120 catalytic site [active] 1232383006121 substrate binding site [chemical binding]; other site 1232383006122 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 1232383006123 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1232383006124 active site 1232383006125 catalytic site [active] 1232383006126 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1232383006127 synthetase active site [active] 1232383006128 NTP binding site [chemical binding]; other site 1232383006129 metal binding site [ion binding]; metal-binding site 1232383006130 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1232383006131 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1232383006132 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1232383006133 RNA binding surface [nucleotide binding]; other site 1232383006134 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1232383006135 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1232383006136 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1232383006137 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1232383006138 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1232383006139 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1232383006140 catalytic site [active] 1232383006141 active site 1232383006142 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1232383006143 threonine dehydratase; Validated; Region: PRK08639 1232383006144 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1232383006145 tetramer interface [polypeptide binding]; other site 1232383006146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232383006147 catalytic residue [active] 1232383006148 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1232383006149 putative Ile/Val binding site [chemical binding]; other site 1232383006150 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1232383006151 substrate binding site [chemical binding]; other site 1232383006152 THF binding site; other site 1232383006153 zinc-binding site [ion binding]; other site 1232383006154 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1232383006155 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1232383006156 active site 1232383006157 PHP Thumb interface [polypeptide binding]; other site 1232383006158 metal binding site [ion binding]; metal-binding site 1232383006159 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1232383006160 generic binding surface II; other site 1232383006161 generic binding surface I; other site 1232383006162 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1232383006163 EamA-like transporter family; Region: EamA; cl17759 1232383006164 EamA-like transporter family; Region: EamA; cl17759 1232383006165 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1232383006166 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1232383006167 Cation efflux family; Region: Cation_efflux; pfam01545 1232383006168 oxidoreductase; Provisional; Region: PRK06128 1232383006169 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232383006170 NAD(P) binding site [chemical binding]; other site 1232383006171 active site 1232383006172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1232383006173 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1232383006174 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1232383006175 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842 1232383006176 dimer interface [polypeptide binding]; other site 1232383006177 active site 1232383006178 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1232383006179 catalytic residues [active] 1232383006180 substrate binding site [chemical binding]; other site 1232383006181 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 1232383006182 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1232383006183 dimer interface [polypeptide binding]; other site 1232383006184 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232383006185 catalytic residue [active] 1232383006186 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1232383006187 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1232383006188 active site 1232383006189 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1232383006190 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1232383006191 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232383006192 Walker A/P-loop; other site 1232383006193 ATP binding site [chemical binding]; other site 1232383006194 Q-loop/lid; other site 1232383006195 ABC transporter signature motif; other site 1232383006196 Walker B; other site 1232383006197 D-loop; other site 1232383006198 H-loop/switch region; other site 1232383006199 ABC transporter; Region: ABC_tran_2; pfam12848 1232383006200 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1232383006201 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1232383006202 active site 1232383006203 homotetramer interface [polypeptide binding]; other site 1232383006204 homodimer interface [polypeptide binding]; other site 1232383006205 DNA polymerase IV; Provisional; Region: PRK03348 1232383006206 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1232383006207 active site 1232383006208 DNA binding site [nucleotide binding] 1232383006209 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 1232383006210 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 1232383006211 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1232383006212 DNA binding residues [nucleotide binding] 1232383006213 putative dimer interface [polypeptide binding]; other site 1232383006214 HEAT repeats; Region: HEAT_2; pfam13646 1232383006215 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1232383006216 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1232383006217 HIGH motif; other site 1232383006218 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1232383006219 active site 1232383006220 KMSKS motif; other site 1232383006221 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1232383006222 tRNA binding surface [nucleotide binding]; other site 1232383006223 anticodon binding site; other site 1232383006224 DivIVA protein; Region: DivIVA; pfam05103 1232383006225 DivIVA domain; Region: DivI1A_domain; TIGR03544 1232383006226 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1232383006227 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1232383006228 Predicted integral membrane protein [Function unknown]; Region: COG0762 1232383006229 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1232383006230 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1232383006231 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1232383006232 catalytic residue [active] 1232383006233 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1232383006234 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1232383006235 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 1232383006236 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1232383006237 nucleotide binding site [chemical binding]; other site 1232383006238 SulA interaction site; other site 1232383006239 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1232383006240 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1232383006241 Cell division protein FtsQ; Region: FtsQ; pfam03799 1232383006242 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1232383006243 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1232383006244 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1232383006245 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1232383006246 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1232383006247 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1232383006248 active site 1232383006249 homodimer interface [polypeptide binding]; other site 1232383006250 cell division protein FtsW; Region: ftsW; TIGR02614 1232383006251 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141 1232383006252 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1232383006253 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1232383006254 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1232383006255 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1232383006256 Mg++ binding site [ion binding]; other site 1232383006257 putative catalytic motif [active] 1232383006258 putative substrate binding site [chemical binding]; other site 1232383006259 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1232383006260 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1232383006261 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1232383006262 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1232383006263 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1232383006264 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1232383006265 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1232383006266 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1232383006267 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1232383006268 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1232383006269 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1232383006270 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1232383006271 MraW methylase family; Region: Methyltransf_5; cl17771 1232383006272 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1232383006273 MraZ protein; Region: MraZ; pfam02381 1232383006274 MraZ protein; Region: MraZ; pfam02381 1232383006275 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1232383006276 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1232383006277 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1232383006278 Coenzyme A binding pocket [chemical binding]; other site 1232383006279 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1232383006280 FAD binding site [chemical binding]; other site 1232383006281 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1232383006282 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1232383006283 substrate binding pocket [chemical binding]; other site 1232383006284 chain length determination region; other site 1232383006285 substrate-Mg2+ binding site; other site 1232383006286 catalytic residues [active] 1232383006287 aspartate-rich region 1; other site 1232383006288 active site lid residues [active] 1232383006289 aspartate-rich region 2; other site 1232383006290 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1232383006291 Helix-turn-helix domain; Region: HTH_17; pfam12728 1232383006292 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1232383006293 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1232383006294 active site 1232383006295 ATP binding site [chemical binding]; other site 1232383006296 substrate binding site [chemical binding]; other site 1232383006297 activation loop (A-loop); other site 1232383006298 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1232383006299 PASTA domain; Region: PASTA; pfam03793 1232383006300 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1232383006301 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1232383006302 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1232383006303 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1232383006304 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1232383006305 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1232383006306 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1232383006307 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1232383006308 Putative esterase; Region: Esterase; pfam00756 1232383006309 Predicted membrane protein [Function unknown]; Region: COG4763 1232383006310 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1232383006311 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1232383006312 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1232383006313 putative acyl-acceptor binding pocket; other site 1232383006314 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1232383006315 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1232383006316 nucleotide binding site [chemical binding]; other site 1232383006317 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1232383006318 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1232383006319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1232383006320 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 1232383006321 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1232383006322 NlpC/P60 family; Region: NLPC_P60; pfam00877 1232383006323 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1232383006324 NlpC/P60 family; Region: NLPC_P60; pfam00877 1232383006325 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1232383006326 heme bH binding site [chemical binding]; other site 1232383006327 intrachain domain interface; other site 1232383006328 heme bL binding site [chemical binding]; other site 1232383006329 interchain domain interface [polypeptide binding]; other site 1232383006330 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1232383006331 Qo binding site; other site 1232383006332 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1232383006333 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1232383006334 iron-sulfur cluster [ion binding]; other site 1232383006335 [2Fe-2S] cluster binding site [ion binding]; other site 1232383006336 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1232383006337 Cytochrome c; Region: Cytochrom_C; pfam00034 1232383006338 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1232383006339 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1232383006340 Subunit I/III interface [polypeptide binding]; other site 1232383006341 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1232383006342 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1232383006343 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1232383006344 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1232383006345 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1232383006346 active site 1232383006347 dimer interface [polypeptide binding]; other site 1232383006348 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1232383006349 Ligand Binding Site [chemical binding]; other site 1232383006350 Molecular Tunnel; other site 1232383006351 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1232383006352 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1232383006353 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1232383006354 homotrimer interface [polypeptide binding]; other site 1232383006355 Walker A motif; other site 1232383006356 GTP binding site [chemical binding]; other site 1232383006357 Walker B motif; other site 1232383006358 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1232383006359 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1232383006360 putative dimer interface [polypeptide binding]; other site 1232383006361 active site pocket [active] 1232383006362 putative cataytic base [active] 1232383006363 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1232383006364 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1232383006365 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232383006366 NAD(P) binding site [chemical binding]; other site 1232383006367 active site 1232383006368 Branched-chain amino acid aminotransferase; Region: DUF3665; pfam12427 1232383006369 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1232383006370 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1232383006371 homodimer interface [polypeptide binding]; other site 1232383006372 substrate-cofactor binding pocket; other site 1232383006373 catalytic residue [active] 1232383006374 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1232383006375 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1232383006376 interface (dimer of trimers) [polypeptide binding]; other site 1232383006377 Substrate-binding/catalytic site; other site 1232383006378 Zn-binding sites [ion binding]; other site 1232383006379 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1232383006380 E3 interaction surface; other site 1232383006381 lipoyl attachment site [posttranslational modification]; other site 1232383006382 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1232383006383 E3 interaction surface; other site 1232383006384 lipoyl attachment site [posttranslational modification]; other site 1232383006385 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1232383006386 E3 interaction surface; other site 1232383006387 lipoyl attachment site [posttranslational modification]; other site 1232383006388 e3 binding domain; Region: E3_binding; pfam02817 1232383006389 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 1232383006390 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1232383006391 lipoate-protein ligase B; Provisional; Region: PRK14345 1232383006392 lipoyl synthase; Provisional; Region: PRK05481 1232383006393 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1232383006394 FeS/SAM binding site; other site 1232383006395 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1232383006396 Predicted permease [General function prediction only]; Region: COG2985 1232383006397 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1232383006398 TrkA-C domain; Region: TrkA_C; pfam02080 1232383006399 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1232383006400 hypothetical protein; Validated; Region: PRK09039 1232383006401 Integrase core domain; Region: rve; pfam00665 1232383006402 Integrase core domain; Region: rve_3; pfam13683 1232383006403 RDD family; Region: RDD; pfam06271 1232383006404 glutamine synthetase, type I; Region: GlnA; TIGR00653 1232383006405 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1232383006406 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1232383006407 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1232383006408 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 1232383006409 nudix motif; other site 1232383006410 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 1232383006411 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232383006412 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1232383006413 homotrimer interaction site [polypeptide binding]; other site 1232383006414 putative active site [active] 1232383006415 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1232383006416 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1232383006417 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232383006418 catalytic residue [active] 1232383006419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383006420 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1232383006421 putative substrate translocation pore; other site 1232383006422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383006423 D-galactonate transporter; Region: 2A0114; TIGR00893 1232383006424 putative substrate translocation pore; other site 1232383006425 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1232383006426 heme binding pocket [chemical binding]; other site 1232383006427 heme ligand [chemical binding]; other site 1232383006428 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1232383006429 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1232383006430 metal binding triad; other site 1232383006431 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1232383006432 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1232383006433 metal binding triad; other site 1232383006434 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1232383006435 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1232383006436 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1232383006437 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1232383006438 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 1232383006439 putative active site; other site 1232383006440 putative metal binding residues [ion binding]; other site 1232383006441 signature motif; other site 1232383006442 putative triphosphate binding site [ion binding]; other site 1232383006443 CHAD domain; Region: CHAD; pfam05235 1232383006444 CHAD domain; Region: CHAD; pfam05235 1232383006445 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1232383006446 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1232383006447 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1232383006448 RNB domain; Region: RNB; pfam00773 1232383006449 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 1232383006450 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1232383006451 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1232383006452 RNA/DNA hybrid binding site [nucleotide binding]; other site 1232383006453 active site 1232383006454 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1232383006455 catalytic core [active] 1232383006456 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1232383006457 Putative zinc ribbon domain; Region: DUF164; pfam02591 1232383006458 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1232383006459 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1232383006460 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1232383006461 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1232383006462 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1232383006463 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232383006464 motif II; other site 1232383006465 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1232383006466 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1232383006467 active site 1232383006468 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1232383006469 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1232383006470 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1232383006471 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1232383006472 dimer interface [polypeptide binding]; other site 1232383006473 TPP-binding site [chemical binding]; other site 1232383006474 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 1232383006475 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232383006476 Walker A/P-loop; other site 1232383006477 ATP binding site [chemical binding]; other site 1232383006478 Q-loop/lid; other site 1232383006479 ABC transporter signature motif; other site 1232383006480 Walker B; other site 1232383006481 D-loop; other site 1232383006482 H-loop/switch region; other site 1232383006483 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 1232383006484 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1232383006485 TM-ABC transporter signature motif; other site 1232383006486 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1232383006487 zinc binding site [ion binding]; other site 1232383006488 putative ligand binding site [chemical binding]; other site 1232383006489 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1232383006490 Serine hydrolase; Region: Ser_hydrolase; cl17834 1232383006491 acyl carrier protein; Provisional; Region: acpP; PRK00982 1232383006492 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1232383006493 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232383006494 active site 1232383006495 motif I; other site 1232383006496 motif II; other site 1232383006497 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232383006498 Uncharacterized conserved protein [Function unknown]; Region: COG4850 1232383006499 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 1232383006500 Beta-lactamase; Region: Beta-lactamase; pfam00144 1232383006501 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1232383006502 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1232383006503 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1232383006504 putative active site [active] 1232383006505 putative metal binding site [ion binding]; other site 1232383006506 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1232383006507 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1232383006508 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1232383006509 DNA primase; Validated; Region: dnaG; PRK05667 1232383006510 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1232383006511 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1232383006512 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1232383006513 active site 1232383006514 metal binding site [ion binding]; metal-binding site 1232383006515 interdomain interaction site; other site 1232383006516 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1232383006517 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1232383006518 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 1232383006519 active site 1232383006520 barstar interaction site; other site 1232383006521 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1232383006522 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1232383006523 glutaminase active site [active] 1232383006524 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1232383006525 dimer interface [polypeptide binding]; other site 1232383006526 active site 1232383006527 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1232383006528 dimer interface [polypeptide binding]; other site 1232383006529 active site 1232383006530 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1232383006531 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1232383006532 Zn2+ binding site [ion binding]; other site 1232383006533 Mg2+ binding site [ion binding]; other site 1232383006534 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1232383006535 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1232383006536 putative active site [active] 1232383006537 Repair protein; Region: Repair_PSII; pfam04536 1232383006538 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1232383006539 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1232383006540 motif 1; other site 1232383006541 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1232383006542 active site 1232383006543 motif 2; other site 1232383006544 motif 3; other site 1232383006545 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1232383006546 anticodon binding site; other site 1232383006547 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1232383006548 dimerization interface [polypeptide binding]; other site 1232383006549 putative DNA binding site [nucleotide binding]; other site 1232383006550 putative Zn2+ binding site [ion binding]; other site 1232383006551 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1232383006552 metal binding site 2 [ion binding]; metal-binding site 1232383006553 putative DNA binding helix; other site 1232383006554 metal binding site 1 [ion binding]; metal-binding site 1232383006555 dimer interface [polypeptide binding]; other site 1232383006556 structural Zn2+ binding site [ion binding]; other site 1232383006557 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1232383006558 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1232383006559 active site 1232383006560 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 1232383006561 diiron binding motif [ion binding]; other site 1232383006562 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 1232383006563 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829 1232383006564 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1232383006565 catalytic residue [active] 1232383006566 putative FPP diphosphate binding site; other site 1232383006567 putative FPP binding hydrophobic cleft; other site 1232383006568 dimer interface [polypeptide binding]; other site 1232383006569 putative IPP diphosphate binding site; other site 1232383006570 Recombination protein O N terminal; Region: RecO_N; pfam11967 1232383006571 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1232383006572 Recombination protein O C terminal; Region: RecO_C; pfam02565 1232383006573 GTPase Era; Reviewed; Region: era; PRK00089 1232383006574 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1232383006575 G1 box; other site 1232383006576 GTP/Mg2+ binding site [chemical binding]; other site 1232383006577 Switch I region; other site 1232383006578 G2 box; other site 1232383006579 Switch II region; other site 1232383006580 G3 box; other site 1232383006581 G4 box; other site 1232383006582 G5 box; other site 1232383006583 KH domain; Region: KH_2; pfam07650 1232383006584 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1232383006585 Domain of unknown function DUF21; Region: DUF21; pfam01595 1232383006586 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1232383006587 Transporter associated domain; Region: CorC_HlyC; smart01091 1232383006588 metal-binding heat shock protein; Provisional; Region: PRK00016 1232383006589 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1232383006590 PhoH-like protein; Region: PhoH; pfam02562 1232383006591 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1232383006592 RNA methyltransferase, RsmE family; Region: TIGR00046 1232383006593 chaperone protein DnaJ; Provisional; Region: PRK14278 1232383006594 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1232383006595 HSP70 interaction site [polypeptide binding]; other site 1232383006596 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1232383006597 Zn binding sites [ion binding]; other site 1232383006598 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1232383006599 dimer interface [polypeptide binding]; other site 1232383006600 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1232383006601 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1232383006602 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1232383006603 FeS/SAM binding site; other site 1232383006604 HemN C-terminal domain; Region: HemN_C; pfam06969 1232383006605 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1232383006606 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1232383006607 acyl-activating enzyme (AAE) consensus motif; other site 1232383006608 putative AMP binding site [chemical binding]; other site 1232383006609 putative active site [active] 1232383006610 putative CoA binding site [chemical binding]; other site 1232383006611 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1232383006612 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1232383006613 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1232383006614 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 1232383006615 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1232383006616 Walker A/P-loop; other site 1232383006617 ATP binding site [chemical binding]; other site 1232383006618 Q-loop/lid; other site 1232383006619 ABC transporter signature motif; other site 1232383006620 Walker B; other site 1232383006621 D-loop; other site 1232383006622 H-loop/switch region; other site 1232383006623 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1232383006624 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1232383006625 active site 1232383006626 Zn binding site [ion binding]; other site 1232383006627 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1232383006628 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1232383006629 substrate binding pocket [chemical binding]; other site 1232383006630 catalytic triad [active] 1232383006631 trehalose synthase; Region: treS_nterm; TIGR02456 1232383006632 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1232383006633 active site 1232383006634 catalytic site [active] 1232383006635 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1232383006636 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1232383006637 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1232383006638 active site 1232383006639 metal binding site [ion binding]; metal-binding site 1232383006640 nudix motif; other site 1232383006641 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1232383006642 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1232383006643 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1232383006644 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232383006645 homodimer interface [polypeptide binding]; other site 1232383006646 catalytic residue [active] 1232383006647 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1232383006648 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1232383006649 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232383006650 choline/carnitine/betaine transport; Region: bcct; TIGR00842 1232383006651 potential frameshift: common BLAST hit: gi|25026970|ref|NP_737024.1| TnpC protein 1232383006652 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 1232383006653 catalytic Zn binding site [ion binding]; other site 1232383006654 putative phosphonate catabolism associated alcohol dehydrogenase; Region: HpnZ_proposed; TIGR03366 1232383006655 structural Zn binding site [ion binding]; other site 1232383006656 tetramer interface [polypeptide binding]; other site 1232383006657 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 1232383006658 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232383006659 motif II; other site 1232383006660 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1232383006661 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1232383006662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232383006663 dimer interface [polypeptide binding]; other site 1232383006664 conserved gate region; other site 1232383006665 ABC-ATPase subunit interface; other site 1232383006666 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 1232383006667 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1232383006668 Q-loop/lid; other site 1232383006669 ABC transporter signature motif; other site 1232383006670 Walker B; other site 1232383006671 D-loop; other site 1232383006672 H-loop/switch region; other site 1232383006673 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1232383006674 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1232383006675 substrate binding pocket [chemical binding]; other site 1232383006676 membrane-bound complex binding site; other site 1232383006677 hinge residues; other site 1232383006678 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1232383006679 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 1232383006680 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1232383006681 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1232383006682 DNA-binding site [nucleotide binding]; DNA binding site 1232383006683 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1232383006684 Predicted permeases [General function prediction only]; Region: COG0679 1232383006685 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1232383006686 FAD binding domain; Region: FAD_binding_4; pfam01565 1232383006687 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1232383006688 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1232383006689 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1232383006690 DNA-binding site [nucleotide binding]; DNA binding site 1232383006691 FCD domain; Region: FCD; pfam07729 1232383006692 DctM-like transporters; Region: DctM; pfam06808 1232383006693 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1232383006694 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1232383006695 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 1232383006696 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1232383006697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232383006698 dimer interface [polypeptide binding]; other site 1232383006699 conserved gate region; other site 1232383006700 putative PBP binding loops; other site 1232383006701 ABC-ATPase subunit interface; other site 1232383006702 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1232383006703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232383006704 dimer interface [polypeptide binding]; other site 1232383006705 conserved gate region; other site 1232383006706 putative PBP binding loops; other site 1232383006707 ABC-ATPase subunit interface; other site 1232383006708 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1232383006709 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1232383006710 Walker A/P-loop; other site 1232383006711 ATP binding site [chemical binding]; other site 1232383006712 Q-loop/lid; other site 1232383006713 ABC transporter signature motif; other site 1232383006714 Walker B; other site 1232383006715 D-loop; other site 1232383006716 H-loop/switch region; other site 1232383006717 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1232383006718 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1232383006719 Walker A/P-loop; other site 1232383006720 ATP binding site [chemical binding]; other site 1232383006721 Q-loop/lid; other site 1232383006722 ABC transporter signature motif; other site 1232383006723 Walker B; other site 1232383006724 D-loop; other site 1232383006725 H-loop/switch region; other site 1232383006726 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1232383006727 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 1232383006728 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1232383006729 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1232383006730 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1232383006731 substrate binding site [chemical binding]; other site 1232383006732 dimer interface [polypeptide binding]; other site 1232383006733 ATP binding site [chemical binding]; other site 1232383006734 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1232383006735 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1232383006736 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1232383006737 bile acid transporter; Region: bass; TIGR00841 1232383006738 Sodium Bile acid symporter family; Region: SBF; pfam01758 1232383006739 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1232383006740 active site 1232383006741 phosphate binding residues; other site 1232383006742 catalytic residues [active] 1232383006743 malate synthase G; Provisional; Region: PRK02999 1232383006744 active site 1232383006745 isocitrate lyase; Provisional; Region: PRK15063 1232383006746 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1232383006747 tetramer interface [polypeptide binding]; other site 1232383006748 active site 1232383006749 Mg2+/Mn2+ binding site [ion binding]; other site 1232383006750 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 1232383006751 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1232383006752 putative active site [active] 1232383006753 putative metal binding site [ion binding]; other site 1232383006754 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1232383006755 Lamin Tail Domain; Region: LTD; pfam00932 1232383006756 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1232383006757 DctM-like transporters; Region: DctM; pfam06808 1232383006758 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1232383006759 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1232383006760 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1232383006761 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1232383006762 GTP-binding protein LepA; Provisional; Region: PRK05433 1232383006763 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1232383006764 G1 box; other site 1232383006765 putative GEF interaction site [polypeptide binding]; other site 1232383006766 GTP/Mg2+ binding site [chemical binding]; other site 1232383006767 Switch I region; other site 1232383006768 G2 box; other site 1232383006769 G3 box; other site 1232383006770 Switch II region; other site 1232383006771 G4 box; other site 1232383006772 G5 box; other site 1232383006773 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1232383006774 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1232383006775 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1232383006776 PemK-like protein; Region: PemK; pfam02452 1232383006777 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1232383006778 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1232383006779 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1232383006780 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1232383006781 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1232383006782 hypothetical protein; Validated; Region: PRK05629 1232383006783 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1232383006784 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1232383006785 Competence protein; Region: Competence; pfam03772 1232383006786 SLBB domain; Region: SLBB; pfam10531 1232383006787 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1232383006788 Helix-hairpin-helix motif; Region: HHH; pfam00633 1232383006789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 1232383006790 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1232383006791 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1232383006792 catalytic core [active] 1232383006793 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1232383006794 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1232383006795 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1232383006796 active site 1232383006797 (T/H)XGH motif; other site 1232383006798 Cutinase; Region: Cutinase; pfam01083 1232383006799 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1232383006800 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1232383006801 putative catalytic cysteine [active] 1232383006802 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 1232383006803 glycerate dehydrogenase; Provisional; Region: PRK06436 1232383006804 putative ligand binding site [chemical binding]; other site 1232383006805 putative NAD binding site [chemical binding]; other site 1232383006806 catalytic site [active] 1232383006807 glutamate 5-kinase; Region: proB; TIGR01027 1232383006808 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1232383006809 nucleotide binding site [chemical binding]; other site 1232383006810 homotetrameric interface [polypeptide binding]; other site 1232383006811 putative phosphate binding site [ion binding]; other site 1232383006812 putative allosteric binding site; other site 1232383006813 PUA domain; Region: PUA; pfam01472 1232383006814 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1232383006815 GTP1/OBG; Region: GTP1_OBG; pfam01018 1232383006816 Obg GTPase; Region: Obg; cd01898 1232383006817 G1 box; other site 1232383006818 GTP/Mg2+ binding site [chemical binding]; other site 1232383006819 Switch I region; other site 1232383006820 G2 box; other site 1232383006821 G3 box; other site 1232383006822 Switch II region; other site 1232383006823 G4 box; other site 1232383006824 G5 box; other site 1232383006825 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1232383006826 xanthine permease; Region: pbuX; TIGR03173 1232383006827 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 1232383006828 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1232383006829 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1232383006830 active site 1232383006831 catalytic tetrad [active] 1232383006832 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 1232383006833 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1232383006834 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1232383006835 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1232383006836 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1232383006837 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1232383006838 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1232383006839 homodimer interface [polypeptide binding]; other site 1232383006840 oligonucleotide binding site [chemical binding]; other site 1232383006841 Pirin-related protein [General function prediction only]; Region: COG1741 1232383006842 Pirin; Region: Pirin; pfam02678 1232383006843 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1232383006844 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1232383006845 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1232383006846 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1232383006847 active site 1232383006848 multimer interface [polypeptide binding]; other site 1232383006849 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1232383006850 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1232383006851 hydrophobic ligand binding site; other site 1232383006852 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1232383006853 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1232383006854 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1232383006855 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1232383006856 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1232383006857 active site 1232383006858 HIGH motif; other site 1232383006859 nucleotide binding site [chemical binding]; other site 1232383006860 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1232383006861 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1232383006862 active site 1232383006863 KMSKS motif; other site 1232383006864 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1232383006865 tRNA binding surface [nucleotide binding]; other site 1232383006866 anticodon binding site; other site 1232383006867 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1232383006868 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1232383006869 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1232383006870 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1232383006871 Actin-like ATPase involved in cell morphogenesis [Cell division and chromosome partitioning]; Region: MreB; COG1077 1232383006872 nucleotide binding site [chemical binding]; other site 1232383006873 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1232383006874 SBD interface [polypeptide binding]; other site 1232383006875 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1232383006876 malate dehydrogenase; Provisional; Region: PRK05442 1232383006877 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1232383006878 NAD(P) binding site [chemical binding]; other site 1232383006879 dimer interface [polypeptide binding]; other site 1232383006880 malate binding site [chemical binding]; other site 1232383006881 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232383006882 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232383006883 Predicted transcriptional regulators [Transcription]; Region: COG1695 1232383006884 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1232383006885 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1232383006886 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1232383006887 iron-sulfur cluster [ion binding]; other site 1232383006888 [2Fe-2S] cluster binding site [ion binding]; other site 1232383006889 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 1232383006890 alpha subunit interface [polypeptide binding]; other site 1232383006891 active site 1232383006892 substrate binding site [chemical binding]; other site 1232383006893 Fe binding site [ion binding]; other site 1232383006894 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1232383006895 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1232383006896 FMN-binding pocket [chemical binding]; other site 1232383006897 flavin binding motif; other site 1232383006898 phosphate binding motif [ion binding]; other site 1232383006899 beta-alpha-beta structure motif; other site 1232383006900 NAD binding pocket [chemical binding]; other site 1232383006901 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1232383006902 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1232383006903 catalytic loop [active] 1232383006904 iron binding site [ion binding]; other site 1232383006905 benzoate transport; Region: 2A0115; TIGR00895 1232383006906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383006907 putative substrate translocation pore; other site 1232383006908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383006909 Predicted permeases [General function prediction only]; Region: COG0679 1232383006910 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1232383006911 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 1232383006912 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1232383006913 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232383006914 Walker A motif; other site 1232383006915 ATP binding site [chemical binding]; other site 1232383006916 Walker B motif; other site 1232383006917 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1232383006918 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844 1232383006919 active site 1232383006920 catalytic triad [active] 1232383006921 oxyanion hole [active] 1232383006922 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1232383006923 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1232383006924 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1232383006925 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1232383006926 Bacterial transcriptional regulator; Region: IclR; pfam01614 1232383006927 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 1232383006928 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1232383006929 dimer interface [polypeptide binding]; other site 1232383006930 active site 1232383006931 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1232383006932 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1232383006933 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1232383006934 DNA binding residues [nucleotide binding] 1232383006935 dimerization interface [polypeptide binding]; other site 1232383006936 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 1232383006937 3-carboxy-cis,cis-muconate cycloisomerase; Region: protocat_pcaB; TIGR02426 1232383006938 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1232383006939 tetramer interface [polypeptide binding]; other site 1232383006940 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 1232383006941 protocatechuate 3,4-dioxygenase, alpha subunit; Region: protocat_alph; TIGR02423 1232383006942 active site 1232383006943 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1232383006944 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1232383006945 active site 1232383006946 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1232383006947 active site 1232383006948 Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829 1232383006949 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1232383006950 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 1232383006951 metal binding site [ion binding]; metal-binding site 1232383006952 substrate binding pocket [chemical binding]; other site 1232383006953 catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438 1232383006954 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1232383006955 active site 1232383006956 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 1232383006957 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1232383006958 iron-sulfur cluster [ion binding]; other site 1232383006959 [2Fe-2S] cluster binding site [ion binding]; other site 1232383006960 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1232383006961 putative alpha subunit interface [polypeptide binding]; other site 1232383006962 putative active site [active] 1232383006963 putative substrate binding site [chemical binding]; other site 1232383006964 Fe binding site [ion binding]; other site 1232383006965 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1232383006966 inter-subunit interface; other site 1232383006967 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 1232383006968 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1232383006969 catalytic loop [active] 1232383006970 iron binding site [ion binding]; other site 1232383006971 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 1232383006972 FAD binding pocket [chemical binding]; other site 1232383006973 FAD binding motif [chemical binding]; other site 1232383006974 phosphate binding motif [ion binding]; other site 1232383006975 beta-alpha-beta structure motif; other site 1232383006976 NAD binding pocket [chemical binding]; other site 1232383006977 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1232383006978 FCD domain; Region: FCD; pfam07729 1232383006979 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 1232383006980 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232383006981 NAD(P) binding site [chemical binding]; other site 1232383006982 active site 1232383006983 AAA ATPase domain; Region: AAA_16; pfam13191 1232383006984 AAA domain; Region: AAA_22; pfam13401 1232383006985 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1232383006986 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1232383006987 DNA binding residues [nucleotide binding] 1232383006988 dimerization interface [polypeptide binding]; other site 1232383006989 benzoate transport; Region: 2A0115; TIGR00895 1232383006990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383006991 putative substrate translocation pore; other site 1232383006992 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383006993 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 1232383006994 benzoate transporter; Region: benE; TIGR00843 1232383006995 PAS domain; Region: PAS; smart00091 1232383006996 PAS domain; Region: PAS_9; pfam13426 1232383006997 putative active site [active] 1232383006998 heme pocket [chemical binding]; other site 1232383006999 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1232383007000 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1232383007001 dimer interface [polypeptide binding]; other site 1232383007002 phosphorylation site [posttranslational modification] 1232383007003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232383007004 ATP binding site [chemical binding]; other site 1232383007005 Mg2+ binding site [ion binding]; other site 1232383007006 G-X-G motif; other site 1232383007007 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1232383007008 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232383007009 active site 1232383007010 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1232383007011 [2Fe-2S] cluster binding site [ion binding]; other site 1232383007012 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1232383007013 putative alpha subunit interface [polypeptide binding]; other site 1232383007014 putative active site [active] 1232383007015 putative substrate binding site [chemical binding]; other site 1232383007016 Fe binding site [ion binding]; other site 1232383007017 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1232383007018 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1232383007019 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232383007020 NAD(P) binding site [chemical binding]; other site 1232383007021 active site 1232383007022 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1232383007023 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1232383007024 FMN-binding pocket [chemical binding]; other site 1232383007025 flavin binding motif; other site 1232383007026 phosphate binding motif [ion binding]; other site 1232383007027 beta-alpha-beta structure motif; other site 1232383007028 NAD binding pocket [chemical binding]; other site 1232383007029 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1232383007030 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1232383007031 catalytic loop [active] 1232383007032 iron binding site [ion binding]; other site 1232383007033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1232383007034 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1232383007035 active site 1232383007036 phosphorylation site [posttranslational modification] 1232383007037 intermolecular recognition site; other site 1232383007038 dimerization interface [polypeptide binding]; other site 1232383007039 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1232383007040 DNA binding residues [nucleotide binding] 1232383007041 dimerization interface [polypeptide binding]; other site 1232383007042 Amidase; Region: Amidase; cl11426 1232383007043 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383007044 putative substrate translocation pore; other site 1232383007045 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1232383007046 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1232383007047 SnoaL-like domain; Region: SnoaL_4; pfam13577 1232383007048 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1232383007049 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1232383007050 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1232383007051 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1232383007052 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1232383007053 oligomer interface [polypeptide binding]; other site 1232383007054 active site residues [active] 1232383007055 Clp protease; Region: CLP_protease; pfam00574 1232383007056 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1232383007057 oligomer interface [polypeptide binding]; other site 1232383007058 active site residues [active] 1232383007059 trigger factor; Provisional; Region: tig; PRK01490 1232383007060 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1232383007061 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1232383007062 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1232383007063 dimerization interface [polypeptide binding]; other site 1232383007064 putative DNA binding site [nucleotide binding]; other site 1232383007065 putative Zn2+ binding site [ion binding]; other site 1232383007066 Beta-lactamase; Region: Beta-lactamase; pfam00144 1232383007067 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1232383007068 RDD family; Region: RDD; pfam06271 1232383007069 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1232383007070 potential frameshift: common BLAST hit: gi|227833069|ref|YP_002834776.1| transposase 1232383007071 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1232383007072 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1232383007073 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1232383007074 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1232383007075 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1232383007076 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1232383007077 Zn binding site [ion binding]; other site 1232383007078 HTH-like domain; Region: HTH_21; pfam13276 1232383007079 Integrase core domain; Region: rve; pfam00665 1232383007080 Integrase core domain; Region: rve_3; pfam13683 1232383007081 Transposase; Region: HTH_Tnp_1; cl17663 1232383007082 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1232383007083 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1232383007084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383007085 metabolite-proton symporter; Region: 2A0106; TIGR00883 1232383007086 putative substrate translocation pore; other site 1232383007087 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1232383007088 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1232383007089 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1232383007090 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1232383007091 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 1232383007092 catalytic Zn binding site [ion binding]; other site 1232383007093 NAD binding site [chemical binding]; other site 1232383007094 structural Zn binding site [ion binding]; other site 1232383007095 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1232383007096 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1232383007097 NAD(P) binding site [chemical binding]; other site 1232383007098 catalytic residues [active] 1232383007099 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232383007100 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 1232383007101 NAD(P) binding site [chemical binding]; other site 1232383007102 active site 1232383007103 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1232383007104 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232383007105 NAD(P) binding site [chemical binding]; other site 1232383007106 active site 1232383007107 Putative cyclase; Region: Cyclase; pfam04199 1232383007108 phytoene desaturase; Region: crtI_fam; TIGR02734 1232383007109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383007110 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1232383007111 putative substrate translocation pore; other site 1232383007112 CMD domain protein, Avi_7170 family; Region: CMD_Avi_7170; TIGR04029 1232383007113 alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030 1232383007114 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1232383007115 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1232383007116 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1232383007117 Walker A/P-loop; other site 1232383007118 ATP binding site [chemical binding]; other site 1232383007119 Q-loop/lid; other site 1232383007120 ABC transporter signature motif; other site 1232383007121 Walker B; other site 1232383007122 D-loop; other site 1232383007123 H-loop/switch region; other site 1232383007124 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1232383007125 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1232383007126 Walker A/P-loop; other site 1232383007127 ATP binding site [chemical binding]; other site 1232383007128 Q-loop/lid; other site 1232383007129 ABC transporter signature motif; other site 1232383007130 Walker B; other site 1232383007131 D-loop; other site 1232383007132 H-loop/switch region; other site 1232383007133 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1232383007134 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1232383007135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232383007136 putative PBP binding loops; other site 1232383007137 dimer interface [polypeptide binding]; other site 1232383007138 ABC-ATPase subunit interface; other site 1232383007139 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1232383007140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232383007141 dimer interface [polypeptide binding]; other site 1232383007142 conserved gate region; other site 1232383007143 putative PBP binding loops; other site 1232383007144 ABC-ATPase subunit interface; other site 1232383007145 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1232383007146 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 1232383007147 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1232383007148 hypothetical protein; Provisional; Region: PRK06062 1232383007149 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1232383007150 inhibitor-cofactor binding pocket; inhibition site 1232383007151 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232383007152 catalytic residue [active] 1232383007153 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1232383007154 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1232383007155 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1232383007156 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1232383007157 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232383007158 motif II; other site 1232383007159 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1232383007160 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1232383007161 short chain dehydrogenase; Provisional; Region: PRK08219 1232383007162 HetN oxidoreductase-like, classical (c) SDR; Region: HetN_like_SDR_c; cd08932 1232383007163 putative NAD(P) binding site [chemical binding]; other site 1232383007164 active site 1232383007165 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1232383007166 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232383007167 cystathionine gamma-synthase; Provisional; Region: PRK07811 1232383007168 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1232383007169 homodimer interface [polypeptide binding]; other site 1232383007170 substrate-cofactor binding pocket; other site 1232383007171 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232383007172 catalytic residue [active] 1232383007173 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1232383007174 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232383007175 Walker A/P-loop; other site 1232383007176 ATP binding site [chemical binding]; other site 1232383007177 Q-loop/lid; other site 1232383007178 ABC transporter signature motif; other site 1232383007179 Walker B; other site 1232383007180 D-loop; other site 1232383007181 H-loop/switch region; other site 1232383007182 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1232383007183 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1232383007184 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1232383007185 apolar tunnel; other site 1232383007186 heme binding site [chemical binding]; other site 1232383007187 dimerization interface [polypeptide binding]; other site 1232383007188 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1232383007189 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 1232383007190 Chromate transporter; Region: Chromate_transp; pfam02417 1232383007191 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1232383007192 active site 1232383007193 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 1232383007194 Sulfatase; Region: Sulfatase; cl17466 1232383007195 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1232383007196 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1232383007197 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232383007198 Walker A/P-loop; other site 1232383007199 ATP binding site [chemical binding]; other site 1232383007200 Q-loop/lid; other site 1232383007201 ABC transporter signature motif; other site 1232383007202 Walker B; other site 1232383007203 D-loop; other site 1232383007204 H-loop/switch region; other site 1232383007205 ABC transporter; Region: ABC_tran_2; pfam12848 1232383007206 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1232383007207 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1232383007208 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1232383007209 dimer interface [polypeptide binding]; other site 1232383007210 ssDNA binding site [nucleotide binding]; other site 1232383007211 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1232383007212 Copper resistance protein D; Region: CopD; pfam05425 1232383007213 Predicted membrane protein [Function unknown]; Region: COG3336 1232383007214 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1232383007215 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1232383007216 active site 1232383007217 dimer interface [polypeptide binding]; other site 1232383007218 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1232383007219 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1232383007220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232383007221 dimer interface [polypeptide binding]; other site 1232383007222 conserved gate region; other site 1232383007223 putative PBP binding loops; other site 1232383007224 ABC-ATPase subunit interface; other site 1232383007225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232383007226 dimer interface [polypeptide binding]; other site 1232383007227 conserved gate region; other site 1232383007228 putative PBP binding loops; other site 1232383007229 ABC-ATPase subunit interface; other site 1232383007230 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1232383007231 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1232383007232 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 1232383007233 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 1232383007234 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1232383007235 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1232383007236 Walker A/P-loop; other site 1232383007237 ATP binding site [chemical binding]; other site 1232383007238 Q-loop/lid; other site 1232383007239 ABC transporter signature motif; other site 1232383007240 Walker B; other site 1232383007241 D-loop; other site 1232383007242 H-loop/switch region; other site 1232383007243 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 1232383007244 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1232383007245 catalytic residues [active] 1232383007246 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1232383007247 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 1232383007248 catalytic Zn binding site [ion binding]; other site 1232383007249 NAD binding site [chemical binding]; other site 1232383007250 structural Zn binding site [ion binding]; other site 1232383007251 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1232383007252 Isochorismatase family; Region: Isochorismatase; pfam00857 1232383007253 catalytic triad [active] 1232383007254 conserved cis-peptide bond; other site 1232383007255 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1232383007256 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232383007257 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1232383007258 CGNR zinc finger; Region: zf-CGNR; pfam11706 1232383007259 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 1232383007260 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 1232383007261 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 1232383007262 Ligand Binding Site [chemical binding]; other site 1232383007263 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 1232383007264 AIR carboxylase; Region: AIRC; smart01001 1232383007265 Uncharacterized conserved protein [Function unknown]; Region: COG1641 1232383007266 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 1232383007267 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1232383007268 classical (c) SDRs; Region: SDR_c; cd05233 1232383007269 NAD(P) binding site [chemical binding]; other site 1232383007270 active site 1232383007271 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1232383007272 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1232383007273 catalytic site [active] 1232383007274 putative active site [active] 1232383007275 putative substrate binding site [chemical binding]; other site 1232383007276 dimer interface [polypeptide binding]; other site 1232383007277 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1232383007278 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 1232383007279 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 1232383007280 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1232383007281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1232383007282 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1232383007283 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1232383007284 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1232383007285 BCCT family transporter; Region: BCCT; cl00569 1232383007286 SdpI/YhfL protein family; Region: SdpI; pfam13630 1232383007287 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1232383007288 glutaminase; Provisional; Region: PRK00971 1232383007289 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 1232383007290 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1232383007291 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1232383007292 dimerization interface [polypeptide binding]; other site 1232383007293 ligand binding site [chemical binding]; other site 1232383007294 glucuronate isomerase; Reviewed; Region: PRK02925 1232383007295 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1232383007296 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1232383007297 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1232383007298 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1232383007299 glucuronide transporter; Provisional; Region: PRK09848 1232383007300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383007301 putative substrate translocation pore; other site 1232383007302 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 1232383007303 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1232383007304 ATP-binding site [chemical binding]; other site 1232383007305 Gluconate-6-phosphate binding site [chemical binding]; other site 1232383007306 Shikimate kinase; Region: SKI; pfam01202 1232383007307 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1232383007308 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1232383007309 active site 1232383007310 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1232383007311 Isochorismatase family; Region: Isochorismatase; pfam00857 1232383007312 catalytic triad [active] 1232383007313 metal binding site [ion binding]; metal-binding site 1232383007314 conserved cis-peptide bond; other site 1232383007315 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1232383007316 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1232383007317 catalytic triad [active] 1232383007318 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232383007319 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232383007320 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1232383007321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383007322 putative substrate translocation pore; other site 1232383007323 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1232383007324 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1232383007325 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1232383007326 phosphate binding site [ion binding]; other site 1232383007327 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1232383007328 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1232383007329 active site 2 [active] 1232383007330 active site 1 [active] 1232383007331 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1232383007332 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1232383007333 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1232383007334 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1232383007335 putative NAD(P) binding site [chemical binding]; other site 1232383007336 active site 1232383007337 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1232383007338 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1232383007339 active site 1232383007340 potential frameshift: common BLAST hit: gi|62391336|ref|YP_226738.1| sugar diacid utilization regulator 1232383007341 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1232383007342 Peptidase family M23; Region: Peptidase_M23; pfam01551 1232383007343 hypothetical protein; Validated; Region: PRK09039 1232383007344 Integrase core domain; Region: rve; pfam00665 1232383007345 Integrase core domain; Region: rve_3; pfam13683 1232383007346 Protein of unknown function, DUF258; Region: DUF258; pfam03193 1232383007347 Glucitol operon activator [Transcription]; Region: GutM; COG4578 1232383007348 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1232383007349 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1232383007350 active site 1232383007351 dimerization interface [polypeptide binding]; other site 1232383007352 ribonuclease PH; Reviewed; Region: rph; PRK00173 1232383007353 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1232383007354 hexamer interface [polypeptide binding]; other site 1232383007355 active site 1232383007356 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1232383007357 glutamate racemase; Provisional; Region: PRK00865 1232383007358 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1232383007359 MarR family; Region: MarR; pfam01047 1232383007360 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1232383007361 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1232383007362 putative active site pocket [active] 1232383007363 cleavage site 1232383007364 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1232383007365 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1232383007366 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1232383007367 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1232383007368 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1232383007369 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1232383007370 active site 1232383007371 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1232383007372 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1232383007373 DEAD_2; Region: DEAD_2; pfam06733 1232383007374 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1232383007375 Peptidyl-tRNA hydrolase [Translation, ribosomal structure and biogenesis]; Region: pth2; COG1990 1232383007376 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1232383007377 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1232383007378 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1232383007379 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232383007380 motif II; other site 1232383007381 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1232383007382 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1232383007383 D-pathway; other site 1232383007384 Putative ubiquinol binding site [chemical binding]; other site 1232383007385 Low-spin heme (heme b) binding site [chemical binding]; other site 1232383007386 Putative water exit pathway; other site 1232383007387 Binuclear center (heme o3/CuB) [ion binding]; other site 1232383007388 K-pathway; other site 1232383007389 Putative proton exit pathway; other site 1232383007390 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1232383007391 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1232383007392 dimer interface [polypeptide binding]; other site 1232383007393 putative radical transfer pathway; other site 1232383007394 diiron center [ion binding]; other site 1232383007395 tyrosyl radical; other site 1232383007396 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1232383007397 Ferritin-like domain; Region: Ferritin; pfam00210 1232383007398 ferroxidase diiron center [ion binding]; other site 1232383007399 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1232383007400 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1232383007401 DNA-binding site [nucleotide binding]; DNA binding site 1232383007402 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1232383007403 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1232383007404 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1232383007405 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1232383007406 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 1232383007407 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1232383007408 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1232383007409 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1232383007410 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1232383007411 active site 1232383007412 dimer interface [polypeptide binding]; other site 1232383007413 catalytic residues [active] 1232383007414 effector binding site; other site 1232383007415 R2 peptide binding site; other site 1232383007416 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1232383007417 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1232383007418 catalytic residues [active] 1232383007419 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1232383007420 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1232383007421 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1232383007422 homodimer interface [polypeptide binding]; other site 1232383007423 NAD binding pocket [chemical binding]; other site 1232383007424 ATP binding pocket [chemical binding]; other site 1232383007425 Mg binding site [ion binding]; other site 1232383007426 active-site loop [active] 1232383007427 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1232383007428 Phosphotransferase enzyme family; Region: APH; pfam01636 1232383007429 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1232383007430 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1232383007431 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1232383007432 NADP binding site [chemical binding]; other site 1232383007433 dimer interface [polypeptide binding]; other site 1232383007434 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1232383007435 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1232383007436 catalytic residues [active] 1232383007437 phosphoglucomutase; Validated; Region: PRK07564 1232383007438 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1232383007439 active site 1232383007440 substrate binding site [chemical binding]; other site 1232383007441 metal binding site [ion binding]; metal-binding site 1232383007442 camphor resistance protein CrcB; Provisional; Region: ccrB; PRK00134 1232383007443 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1232383007444 hypothetical protein; Provisional; Region: PRK05463 1232383007445 Predicted membrane protein [General function prediction only]; Region: COG4194 1232383007446 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1232383007447 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1232383007448 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1232383007449 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1232383007450 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1232383007451 FtsX-like permease family; Region: FtsX; pfam02687 1232383007452 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1232383007453 FtsX-like permease family; Region: FtsX; pfam02687 1232383007454 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1232383007455 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1232383007456 Walker A/P-loop; other site 1232383007457 ATP binding site [chemical binding]; other site 1232383007458 Q-loop/lid; other site 1232383007459 ABC transporter signature motif; other site 1232383007460 Walker B; other site 1232383007461 D-loop; other site 1232383007462 H-loop/switch region; other site 1232383007463 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1232383007464 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1232383007465 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1232383007466 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1232383007467 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1232383007468 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1232383007469 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1232383007470 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1232383007471 MFS/sugar transport protein; Region: MFS_2; pfam13347 1232383007472 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1232383007473 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1232383007474 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232383007475 S-adenosylmethionine binding site [chemical binding]; other site 1232383007476 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1232383007477 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1232383007478 hinge; other site 1232383007479 active site 1232383007480 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1232383007481 GAF domain; Region: GAF_2; pfam13185 1232383007482 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1232383007483 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1232383007484 DNA binding residues [nucleotide binding] 1232383007485 dimerization interface [polypeptide binding]; other site 1232383007486 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1232383007487 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1232383007488 dimer interface [polypeptide binding]; other site 1232383007489 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232383007490 catalytic residue [active] 1232383007491 serine O-acetyltransferase; Region: cysE; TIGR01172 1232383007492 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1232383007493 trimer interface [polypeptide binding]; other site 1232383007494 active site 1232383007495 substrate binding site [chemical binding]; other site 1232383007496 CoA binding site [chemical binding]; other site 1232383007497 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1232383007498 Coenzyme A binding pocket [chemical binding]; other site 1232383007499 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1232383007500 CoA binding domain; Region: CoA_binding; smart00881 1232383007501 CoA-ligase; Region: Ligase_CoA; pfam00549 1232383007502 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1232383007503 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1232383007504 CoA-ligase; Region: Ligase_CoA; pfam00549 1232383007505 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1232383007506 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1232383007507 catalytic residues [active] 1232383007508 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1232383007509 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1232383007510 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1232383007511 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1232383007512 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1232383007513 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1232383007514 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1232383007515 FMN binding site [chemical binding]; other site 1232383007516 active site 1232383007517 catalytic residues [active] 1232383007518 substrate binding site [chemical binding]; other site 1232383007519 Phosphate uptake regulator [Inorganic ion transport and metabolism]; Region: PhoU; COG0704 1232383007520 PhoU domain; Region: PhoU; pfam01895 1232383007521 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1232383007522 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1232383007523 Walker A/P-loop; other site 1232383007524 ATP binding site [chemical binding]; other site 1232383007525 Q-loop/lid; other site 1232383007526 ABC transporter signature motif; other site 1232383007527 Walker B; other site 1232383007528 D-loop; other site 1232383007529 H-loop/switch region; other site 1232383007530 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1232383007531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232383007532 dimer interface [polypeptide binding]; other site 1232383007533 conserved gate region; other site 1232383007534 putative PBP binding loops; other site 1232383007535 ABC-ATPase subunit interface; other site 1232383007536 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1232383007537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232383007538 dimer interface [polypeptide binding]; other site 1232383007539 conserved gate region; other site 1232383007540 putative PBP binding loops; other site 1232383007541 ABC-ATPase subunit interface; other site 1232383007542 PBP superfamily domain; Region: PBP_like_2; cl17296 1232383007543 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1232383007544 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1232383007545 Coenzyme A binding pocket [chemical binding]; other site 1232383007546 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1232383007547 Coenzyme A binding pocket [chemical binding]; other site 1232383007548 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1232383007549 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1232383007550 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1232383007551 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1232383007552 heme-binding site [chemical binding]; other site 1232383007553 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1232383007554 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1232383007555 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232383007556 catalytic residue [active] 1232383007557 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1232383007558 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1232383007559 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1232383007560 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1232383007561 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1232383007562 Helix-turn-helix domain; Region: HTH_38; pfam13936 1232383007563 Homeodomain-like domain; Region: HTH_32; pfam13565 1232383007564 Integrase core domain; Region: rve; pfam00665 1232383007565 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1232383007566 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1232383007567 dimerization interface [polypeptide binding]; other site 1232383007568 putative ATP binding site [chemical binding]; other site 1232383007569 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1232383007570 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1232383007571 active site 1232383007572 tetramer interface [polypeptide binding]; other site 1232383007573 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1232383007574 active site 1232383007575 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1232383007576 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1232383007577 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1232383007578 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1232383007579 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1232383007580 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1232383007581 dimerization interface [polypeptide binding]; other site 1232383007582 ATP binding site [chemical binding]; other site 1232383007583 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1232383007584 dimerization interface [polypeptide binding]; other site 1232383007585 ATP binding site [chemical binding]; other site 1232383007586 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1232383007587 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1232383007588 putative active site [active] 1232383007589 catalytic triad [active] 1232383007590 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1232383007591 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1232383007592 catalytic residues [active] 1232383007593 dimer interface [polypeptide binding]; other site 1232383007594 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 1232383007595 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1232383007596 generic binding surface II; other site 1232383007597 generic binding surface I; other site 1232383007598 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 1232383007599 putative active site [active] 1232383007600 putative catalytic site [active] 1232383007601 putative Mg binding site IVb [ion binding]; other site 1232383007602 putative phosphate binding site [ion binding]; other site 1232383007603 putative DNA binding site [nucleotide binding]; other site 1232383007604 putative Mg binding site IVa [ion binding]; other site 1232383007605 Predicted deacetylase [General function prediction only]; Region: COG3233 1232383007606 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 1232383007607 putative active site [active] 1232383007608 putative Zn binding site [ion binding]; other site 1232383007609 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1232383007610 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1232383007611 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1232383007612 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1232383007613 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1232383007614 ATP binding site [chemical binding]; other site 1232383007615 active site 1232383007616 substrate binding site [chemical binding]; other site 1232383007617 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1232383007618 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1232383007619 tetramer interface [polypeptide binding]; other site 1232383007620 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1232383007621 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1232383007622 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232383007623 homodimer interface [polypeptide binding]; other site 1232383007624 catalytic residue [active] 1232383007625 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1232383007626 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1232383007627 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1232383007628 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1232383007629 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1232383007630 nucleotide binding site/active site [active] 1232383007631 HIT family signature motif; other site 1232383007632 catalytic residue [active] 1232383007633 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1232383007634 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232383007635 S-adenosylmethionine binding site [chemical binding]; other site 1232383007636 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1232383007637 POT family; Region: PTR2; cl17359 1232383007638 POT family; Region: PTR2; cl17359 1232383007639 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05630 1232383007640 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1232383007641 inhibitor-cofactor binding pocket; inhibition site 1232383007642 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232383007643 catalytic residue [active] 1232383007644 AAA domain; Region: AAA_26; pfam13500 1232383007645 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1232383007646 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 1232383007647 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1232383007648 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1232383007649 dimerization interface [polypeptide binding]; other site 1232383007650 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1232383007651 dimer interface [polypeptide binding]; other site 1232383007652 phosphorylation site [posttranslational modification] 1232383007653 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232383007654 ATP binding site [chemical binding]; other site 1232383007655 Mg2+ binding site [ion binding]; other site 1232383007656 G-X-G motif; other site 1232383007657 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1232383007658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1232383007659 active site 1232383007660 phosphorylation site [posttranslational modification] 1232383007661 intermolecular recognition site; other site 1232383007662 dimerization interface [polypeptide binding]; other site 1232383007663 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1232383007664 DNA binding site [nucleotide binding] 1232383007665 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1232383007666 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1232383007667 DNA binding residues [nucleotide binding] 1232383007668 dimer interface [polypeptide binding]; other site 1232383007669 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1232383007670 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1232383007671 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 1232383007672 dimer interface [polypeptide binding]; other site 1232383007673 active site 1232383007674 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1232383007675 substrate binding site [chemical binding]; other site 1232383007676 catalytic residue [active] 1232383007677 pyruvate dehydrogenase; Provisional; Region: PRK06546 1232383007678 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1232383007679 PYR/PP interface [polypeptide binding]; other site 1232383007680 dimer interface [polypeptide binding]; other site 1232383007681 tetramer interface [polypeptide binding]; other site 1232383007682 TPP binding site [chemical binding]; other site 1232383007683 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1232383007684 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1232383007685 TPP-binding site [chemical binding]; other site 1232383007686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383007687 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1232383007688 putative substrate translocation pore; other site 1232383007689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383007690 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232383007691 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232383007692 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1232383007693 Ion channel regulatory protein UNC-93; Region: UNC-93; pfam05978 1232383007694 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 1232383007695 active site 1232383007696 catalytic residues [active] 1232383007697 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 1232383007698 active site 1232383007699 catalytic residues [active] 1232383007700 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843 1232383007701 putative succinate dehydrogenase; Reviewed; Region: PRK12842 1232383007702 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1232383007703 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1232383007704 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1232383007705 NAD(P) binding site [chemical binding]; other site 1232383007706 YCII-related domain; Region: YCII; cl00999 1232383007707 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383007708 metabolite-proton symporter; Region: 2A0106; TIGR00883 1232383007709 putative substrate translocation pore; other site 1232383007710 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1232383007711 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1232383007712 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1232383007713 dimerization interface [polypeptide binding]; other site 1232383007714 substrate binding pocket [chemical binding]; other site 1232383007715 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 1232383007716 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl17742 1232383007717 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1232383007718 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1232383007719 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232383007720 active site 1232383007721 motif I; other site 1232383007722 motif II; other site 1232383007723 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1232383007724 Uncharacterized conserved protein [Function unknown]; Region: COG5646 1232383007725 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 1232383007726 non-specific DNA binding site [nucleotide binding]; other site 1232383007727 salt bridge; other site 1232383007728 sequence-specific DNA binding site [nucleotide binding]; other site 1232383007729 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1232383007730 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1232383007731 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1232383007732 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1232383007733 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1232383007734 active site 1232383007735 homotetramer interface [polypeptide binding]; other site 1232383007736 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1232383007737 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1232383007738 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1232383007739 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1232383007740 DNA binding site [nucleotide binding] 1232383007741 domain linker motif; other site 1232383007742 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 1232383007743 putative dimerization interface [polypeptide binding]; other site 1232383007744 putative ligand binding site [chemical binding]; other site 1232383007745 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1232383007746 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1232383007747 intersubunit interface [polypeptide binding]; other site 1232383007748 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1232383007749 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232383007750 Walker A/P-loop; other site 1232383007751 ATP binding site [chemical binding]; other site 1232383007752 Q-loop/lid; other site 1232383007753 ABC transporter signature motif; other site 1232383007754 Walker B; other site 1232383007755 D-loop; other site 1232383007756 H-loop/switch region; other site 1232383007757 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1232383007758 dimer interface [polypeptide binding]; other site 1232383007759 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1232383007760 putative PBP binding regions; other site 1232383007761 ABC-ATPase subunit interface; other site 1232383007762 hypothetical protein; Provisional; Region: PRK12839 1232383007763 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1232383007764 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1232383007765 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1232383007766 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1232383007767 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1232383007768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383007769 metabolite-proton symporter; Region: 2A0106; TIGR00883 1232383007770 putative substrate translocation pore; other site 1232383007771 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1232383007772 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1232383007773 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1232383007774 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1232383007775 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1232383007776 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1232383007777 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1232383007778 active site 1232383007779 HIGH motif; other site 1232383007780 nucleotide binding site [chemical binding]; other site 1232383007781 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1232383007782 KMSKS motif; other site 1232383007783 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1232383007784 tRNA binding surface [nucleotide binding]; other site 1232383007785 anticodon binding site; other site 1232383007786 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1232383007787 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1232383007788 active site turn [active] 1232383007789 phosphorylation site [posttranslational modification] 1232383007790 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1232383007791 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1232383007792 HPr interaction site; other site 1232383007793 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1232383007794 active site 1232383007795 phosphorylation site [posttranslational modification] 1232383007796 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1232383007797 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1232383007798 substrate binding [chemical binding]; other site 1232383007799 active site 1232383007800 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1232383007801 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1232383007802 active site 1232383007803 trimer interface [polypeptide binding]; other site 1232383007804 allosteric site; other site 1232383007805 active site lid [active] 1232383007806 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1232383007807 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1232383007808 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1232383007809 active site 1232383007810 dimer interface [polypeptide binding]; other site 1232383007811 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1232383007812 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1232383007813 inhibitor site; inhibition site 1232383007814 active site 1232383007815 dimer interface [polypeptide binding]; other site 1232383007816 catalytic residue [active] 1232383007817 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1232383007818 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1232383007819 nucleotide binding site [chemical binding]; other site 1232383007820 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 1232383007821 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1232383007822 putative active site cavity [active] 1232383007823 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 1232383007824 catalytic site [active] 1232383007825 Asp-box motif; other site 1232383007826 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1232383007827 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1232383007828 DNA-binding site [nucleotide binding]; DNA binding site 1232383007829 FCD domain; Region: FCD; pfam07729 1232383007830 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1232383007831 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1232383007832 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1232383007833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232383007834 dimer interface [polypeptide binding]; other site 1232383007835 conserved gate region; other site 1232383007836 putative PBP binding loops; other site 1232383007837 ABC-ATPase subunit interface; other site 1232383007838 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1232383007839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232383007840 dimer interface [polypeptide binding]; other site 1232383007841 conserved gate region; other site 1232383007842 putative PBP binding loops; other site 1232383007843 ABC-ATPase subunit interface; other site 1232383007844 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1232383007845 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1232383007846 Walker A/P-loop; other site 1232383007847 ATP binding site [chemical binding]; other site 1232383007848 Q-loop/lid; other site 1232383007849 ABC transporter signature motif; other site 1232383007850 Walker B; other site 1232383007851 D-loop; other site 1232383007852 H-loop/switch region; other site 1232383007853 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1232383007854 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1232383007855 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1232383007856 Walker A/P-loop; other site 1232383007857 ATP binding site [chemical binding]; other site 1232383007858 Q-loop/lid; other site 1232383007859 ABC transporter signature motif; other site 1232383007860 Walker B; other site 1232383007861 D-loop; other site 1232383007862 H-loop/switch region; other site 1232383007863 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1232383007864 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1232383007865 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1232383007866 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1232383007867 putative DNA binding site [nucleotide binding]; other site 1232383007868 putative Zn2+ binding site [ion binding]; other site 1232383007869 AsnC family; Region: AsnC_trans_reg; pfam01037 1232383007870 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1232383007871 homotrimer interaction site [polypeptide binding]; other site 1232383007872 zinc binding site [ion binding]; other site 1232383007873 CDP-binding sites; other site 1232383007874 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1232383007875 substrate binding site; other site 1232383007876 dimer interface; other site 1232383007877 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1232383007878 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1232383007879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1232383007880 active site 1232383007881 phosphorylation site [posttranslational modification] 1232383007882 intermolecular recognition site; other site 1232383007883 dimerization interface [polypeptide binding]; other site 1232383007884 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1232383007885 DNA binding site [nucleotide binding] 1232383007886 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1232383007887 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1232383007888 dimerization interface [polypeptide binding]; other site 1232383007889 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1232383007890 dimer interface [polypeptide binding]; other site 1232383007891 phosphorylation site [posttranslational modification] 1232383007892 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232383007893 ATP binding site [chemical binding]; other site 1232383007894 Mg2+ binding site [ion binding]; other site 1232383007895 G-X-G motif; other site 1232383007896 DNA repair protein RadA; Provisional; Region: PRK11823 1232383007897 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1232383007898 Walker A motif; other site 1232383007899 ATP binding site [chemical binding]; other site 1232383007900 Walker B motif; other site 1232383007901 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1232383007902 Predicted nucleic-acid-binding protein (contains the HHH domain) [General function prediction only]; Region: COG1623 1232383007903 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1232383007904 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1232383007905 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1232383007906 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1232383007907 NAD(P) binding site [chemical binding]; other site 1232383007908 catalytic residues [active] 1232383007909 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1232383007910 active site clefts [active] 1232383007911 zinc binding site [ion binding]; other site 1232383007912 dimer interface [polypeptide binding]; other site 1232383007913 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1232383007914 endonuclease III; Region: ENDO3c; smart00478 1232383007915 minor groove reading motif; other site 1232383007916 helix-hairpin-helix signature motif; other site 1232383007917 substrate binding pocket [chemical binding]; other site 1232383007918 active site 1232383007919 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1232383007920 Mono-functional DNA-alkylating methyl methanesulfonate N-term; Region: MMS1_N; pfam10433 1232383007921 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 1232383007922 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1232383007923 acetoin reductases; Region: 23BDH; TIGR02415 1232383007924 NAD binding site [chemical binding]; other site 1232383007925 homotetramer interface [polypeptide binding]; other site 1232383007926 homodimer interface [polypeptide binding]; other site 1232383007927 active site 1232383007928 substrate binding site [chemical binding]; other site 1232383007929 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1232383007930 Clp amino terminal domain; Region: Clp_N; pfam02861 1232383007931 Clp amino terminal domain; Region: Clp_N; pfam02861 1232383007932 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232383007933 Walker A motif; other site 1232383007934 ATP binding site [chemical binding]; other site 1232383007935 Walker B motif; other site 1232383007936 arginine finger; other site 1232383007937 UvrB/uvrC motif; Region: UVR; pfam02151 1232383007938 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232383007939 Walker A motif; other site 1232383007940 ATP binding site [chemical binding]; other site 1232383007941 Walker B motif; other site 1232383007942 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1232383007943 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1232383007944 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 1232383007945 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1232383007946 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1232383007947 active site 1232383007948 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1232383007949 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1232383007950 phenol 2-monooxygenase; Provisional; Region: PRK08294 1232383007951 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1232383007952 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979 1232383007953 dimer interface [polypeptide binding]; other site 1232383007954 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1232383007955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383007956 putative substrate translocation pore; other site 1232383007957 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1232383007958 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1232383007959 dimer interface [polypeptide binding]; other site 1232383007960 putative anticodon binding site; other site 1232383007961 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1232383007962 motif 1; other site 1232383007963 dimer interface [polypeptide binding]; other site 1232383007964 active site 1232383007965 motif 2; other site 1232383007966 motif 3; other site 1232383007967 Panthothenate synthetase [Coenzyme metabolism]; Region: PanC; COG0414 1232383007968 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1232383007969 active site 1232383007970 nucleotide binding site [chemical binding]; other site 1232383007971 HIGH motif; other site 1232383007972 KMSKS motif; other site 1232383007973 Rossmann-like domain; Region: Rossmann-like; pfam10727 1232383007974 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1232383007975 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1232383007976 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1232383007977 catalytic center binding site [active] 1232383007978 ATP binding site [chemical binding]; other site 1232383007979 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1232383007980 homooctamer interface [polypeptide binding]; other site 1232383007981 active site 1232383007982 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1232383007983 dihydropteroate synthase; Region: DHPS; TIGR01496 1232383007984 substrate binding pocket [chemical binding]; other site 1232383007985 dimer interface [polypeptide binding]; other site 1232383007986 inhibitor binding site; inhibition site 1232383007987 GTP cyclohydrolase I; Provisional; Region: PLN03044 1232383007988 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1232383007989 homodecamer interface [polypeptide binding]; other site 1232383007990 active site 1232383007991 putative catalytic site residues [active] 1232383007992 zinc binding site [ion binding]; other site 1232383007993 GTP-CH-I/GFRP interaction surface; other site 1232383007994 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1232383007995 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232383007996 Walker A motif; other site 1232383007997 ATP binding site [chemical binding]; other site 1232383007998 Walker B motif; other site 1232383007999 arginine finger; other site 1232383008000 Peptidase family M41; Region: Peptidase_M41; pfam01434 1232383008001 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1232383008002 active site 1232383008003 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1232383008004 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1232383008005 Ligand Binding Site [chemical binding]; other site 1232383008006 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 1232383008007 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1232383008008 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1232383008009 dimer interface [polypeptide binding]; other site 1232383008010 substrate binding site [chemical binding]; other site 1232383008011 metal binding sites [ion binding]; metal-binding site 1232383008012 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 1232383008013 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232383008014 S-adenosylmethionine binding site [chemical binding]; other site 1232383008015 Predicted membrane protein [Function unknown]; Region: COG3766 1232383008016 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1232383008017 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 1232383008018 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 1232383008019 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1232383008020 CAT RNA binding domain; Region: CAT_RBD; smart01061 1232383008021 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1232383008022 PRD domain; Region: PRD; pfam00874 1232383008023 PRD domain; Region: PRD; pfam00874 1232383008024 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1232383008025 beta-galactosidase; Region: BGL; TIGR03356 1232383008026 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1232383008027 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1232383008028 active site turn [active] 1232383008029 phosphorylation site [posttranslational modification] 1232383008030 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1232383008031 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1232383008032 HPr interaction site; other site 1232383008033 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1232383008034 active site 1232383008035 phosphorylation site [posttranslational modification] 1232383008036 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1232383008037 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1232383008038 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232383008039 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1232383008040 active site residue [active] 1232383008041 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1232383008042 MarR family; Region: MarR; pfam01047 1232383008043 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232383008044 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1232383008045 acyl-activating enzyme (AAE) consensus motif; other site 1232383008046 AMP binding site [chemical binding]; other site 1232383008047 active site 1232383008048 CoA binding site [chemical binding]; other site 1232383008049 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232383008050 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 1232383008051 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1232383008052 putative CoA binding site [chemical binding]; other site 1232383008053 putative trimer interface [polypeptide binding]; other site 1232383008054 Protein of unknown function (DUF3754); Region: DUF3754; pfam12576 1232383008055 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1232383008056 putative trimer interface [polypeptide binding]; other site 1232383008057 putative CoA binding site [chemical binding]; other site 1232383008058 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 1232383008059 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 1232383008060 NAD(P) binding site [chemical binding]; other site 1232383008061 catalytic residues [active] 1232383008062 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1232383008063 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1232383008064 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1232383008065 ring oligomerisation interface [polypeptide binding]; other site 1232383008066 ATP/Mg binding site [chemical binding]; other site 1232383008067 stacking interactions; other site 1232383008068 hinge regions; other site 1232383008069 Tubulin like; Region: Tubulin_2; pfam13809 1232383008070 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1232383008071 metal ion-dependent adhesion site (MIDAS); other site 1232383008072 hypothetical protein; Provisional; Region: PRK07907 1232383008073 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1232383008074 active site 1232383008075 metal binding site [ion binding]; metal-binding site 1232383008076 dimer interface [polypeptide binding]; other site 1232383008077 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1232383008078 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 1232383008079 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1232383008080 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1232383008081 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1232383008082 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 1232383008083 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 1232383008084 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1232383008085 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1232383008086 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948 1232383008087 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12592 1232383008088 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1232383008089 carboxylate-amine ligase; Provisional; Region: PRK13517 1232383008090 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1232383008091 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1232383008092 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1232383008093 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1232383008094 active site 1232383008095 catalytic residues [active] 1232383008096 metal binding site [ion binding]; metal-binding site 1232383008097 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1232383008098 Coenzyme A binding pocket [chemical binding]; other site 1232383008099 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1232383008100 putative catalytic site [active] 1232383008101 putative phosphate binding site [ion binding]; other site 1232383008102 active site 1232383008103 metal binding site A [ion binding]; metal-binding site 1232383008104 DNA binding site [nucleotide binding] 1232383008105 putative AP binding site [nucleotide binding]; other site 1232383008106 putative metal binding site B [ion binding]; other site 1232383008107 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1232383008108 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1232383008109 putative active site [active] 1232383008110 catalytic site [active] 1232383008111 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1232383008112 putative active site [active] 1232383008113 catalytic site [active] 1232383008114 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1232383008115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383008116 putative substrate translocation pore; other site 1232383008117 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1232383008118 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1232383008119 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1232383008120 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1232383008121 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1232383008122 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1232383008123 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1232383008124 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232383008125 Walker A/P-loop; other site 1232383008126 ATP binding site [chemical binding]; other site 1232383008127 Q-loop/lid; other site 1232383008128 ABC transporter signature motif; other site 1232383008129 Walker B; other site 1232383008130 D-loop; other site 1232383008131 H-loop/switch region; other site 1232383008132 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1232383008133 nudix motif; other site 1232383008134 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1232383008135 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1232383008136 substrate binding pocket [chemical binding]; other site 1232383008137 membrane-bound complex binding site; other site 1232383008138 hinge residues; other site 1232383008139 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 1232383008140 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1232383008141 active site 1232383008142 ATP binding site [chemical binding]; other site 1232383008143 substrate binding site [chemical binding]; other site 1232383008144 activation loop (A-loop); other site 1232383008145 propionate/acetate kinase; Provisional; Region: PRK12379 1232383008146 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1232383008147 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1232383008148 ferredoxin-NADP+ reductase; Region: PLN02852 1232383008149 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1232383008150 Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153 1232383008151 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1232383008152 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232383008153 ATP-grasp domain; Region: ATP-grasp; pfam02222 1232383008154 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1232383008155 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1232383008156 GDP-binding site [chemical binding]; other site 1232383008157 ACT binding site; other site 1232383008158 IMP binding site; other site 1232383008159 cardiolipin synthetase; Reviewed; Region: PRK12452 1232383008160 Predicted membrane protein [Function unknown]; Region: COG4129 1232383008161 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1232383008162 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1232383008163 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1232383008164 active site 1232383008165 intersubunit interface [polypeptide binding]; other site 1232383008166 zinc binding site [ion binding]; other site 1232383008167 Na+ binding site [ion binding]; other site 1232383008168 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 1232383008169 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1232383008170 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1232383008171 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1232383008172 active site 1232383008173 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1232383008174 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1232383008175 active site residue [active] 1232383008176 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1232383008177 active site residue [active] 1232383008178 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1232383008179 sequence-specific DNA binding site [nucleotide binding]; other site 1232383008180 salt bridge; other site 1232383008181 H+ Antiporter protein; Region: 2A0121; TIGR00900 1232383008182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383008183 putative substrate translocation pore; other site 1232383008184 Domain of unknown function (DUF4265); Region: DUF4265; pfam14085 1232383008185 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1232383008186 Clp amino terminal domain; Region: Clp_N; pfam02861 1232383008187 Clp amino terminal domain; Region: Clp_N; pfam02861 1232383008188 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232383008189 Walker A motif; other site 1232383008190 ATP binding site [chemical binding]; other site 1232383008191 Walker B motif; other site 1232383008192 arginine finger; other site 1232383008193 Protein of unknown function (DUF2730); Region: DUF2730; pfam10805 1232383008194 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232383008195 Walker A motif; other site 1232383008196 ATP binding site [chemical binding]; other site 1232383008197 Walker B motif; other site 1232383008198 arginine finger; other site 1232383008199 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1232383008200 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 1232383008201 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1232383008202 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1232383008203 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232383008204 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1232383008205 Uncharacterized conserved protein [Function unknown]; Region: COG4127 1232383008206 Restriction endonuclease; Region: Mrr_cat; pfam04471 1232383008207 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232383008208 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1232383008209 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1232383008210 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1232383008211 Coenzyme A binding pocket [chemical binding]; other site 1232383008212 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 1232383008213 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 1232383008214 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1232383008215 FAD binding pocket [chemical binding]; other site 1232383008216 conserved FAD binding motif [chemical binding]; other site 1232383008217 phosphate binding motif [ion binding]; other site 1232383008218 beta-alpha-beta structure motif; other site 1232383008219 NAD binding pocket [chemical binding]; other site 1232383008220 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1232383008221 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1232383008222 putative active site [active] 1232383008223 catalytic triad [active] 1232383008224 putative dimer interface [polypeptide binding]; other site 1232383008225 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1232383008226 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1232383008227 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1232383008228 NAD(P) binding site [chemical binding]; other site 1232383008229 catalytic residues [active] 1232383008230 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1232383008231 DNA binding residues [nucleotide binding] 1232383008232 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1232383008233 putative dimer interface [polypeptide binding]; other site 1232383008234 chaperone protein DnaJ; Provisional; Region: PRK14279 1232383008235 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1232383008236 HSP70 interaction site [polypeptide binding]; other site 1232383008237 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1232383008238 Zn binding sites [ion binding]; other site 1232383008239 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1232383008240 dimer interface [polypeptide binding]; other site 1232383008241 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1232383008242 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1232383008243 dimer interface [polypeptide binding]; other site 1232383008244 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1232383008245 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1232383008246 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1232383008247 nucleotide binding site [chemical binding]; other site 1232383008248 NEF interaction site [polypeptide binding]; other site 1232383008249 SBD interface [polypeptide binding]; other site 1232383008250 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1232383008251 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1232383008252 nucleosidase; Provisional; Region: PRK05634 1232383008253 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1232383008254 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 1232383008255 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 1232383008256 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1232383008257 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1232383008258 NAD binding site [chemical binding]; other site 1232383008259 substrate binding site [chemical binding]; other site 1232383008260 catalytic Zn binding site [ion binding]; other site 1232383008261 tetramer interface [polypeptide binding]; other site 1232383008262 structural Zn binding site [ion binding]; other site 1232383008263 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 1232383008264 Mrr N-terminal domain; Region: Mrr_N; pfam14338 1232383008265 Restriction endonuclease; Region: Mrr_cat; pfam04471 1232383008266 Abi-like protein; Region: Abi_2; pfam07751 1232383008267 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 1232383008268 putative monooxygenase; Provisional; Region: PRK11118 1232383008269 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1232383008270 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1232383008271 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1232383008272 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1232383008273 putative active site [active] 1232383008274 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1232383008275 active site 1232383008276 sulfate adenylyltransferase, large subunit; Region: CysN; TIGR02034 1232383008277 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1232383008278 CysD dimerization site [polypeptide binding]; other site 1232383008279 G1 box; other site 1232383008280 putative GEF interaction site [polypeptide binding]; other site 1232383008281 GTP/Mg2+ binding site [chemical binding]; other site 1232383008282 Switch I region; other site 1232383008283 G2 box; other site 1232383008284 G3 box; other site 1232383008285 Switch II region; other site 1232383008286 G4 box; other site 1232383008287 G5 box; other site 1232383008288 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1232383008289 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 1232383008290 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1232383008291 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1232383008292 Active Sites [active] 1232383008293 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1232383008294 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1232383008295 Active Sites [active] 1232383008296 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1232383008297 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1232383008298 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1232383008299 ferredoxin-NADP+ reductase; Region: PLN02852 1232383008300 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1232383008301 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1232383008302 dimer interface [polypeptide binding]; other site 1232383008303 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1232383008304 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1232383008305 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1232383008306 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1232383008307 Predicted ATPase [General function prediction only]; Region: COG3910 1232383008308 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1232383008309 Walker A/P-loop; other site 1232383008310 ATP binding site [chemical binding]; other site 1232383008311 Q-loop/lid; other site 1232383008312 ABC transporter signature motif; other site 1232383008313 Walker B; other site 1232383008314 D-loop; other site 1232383008315 H-loop/switch region; other site 1232383008316 Predicted ATPase [General function prediction only]; Region: COG3910 1232383008317 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1232383008318 Walker A/P-loop; other site 1232383008319 ATP binding site [chemical binding]; other site 1232383008320 Q-loop/lid; other site 1232383008321 ABC transporter signature motif; other site 1232383008322 Walker B; other site 1232383008323 D-loop; other site 1232383008324 H-loop/switch region; other site 1232383008325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383008326 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1232383008327 putative substrate translocation pore; other site 1232383008328 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 1232383008329 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1232383008330 putative metal binding site [ion binding]; other site 1232383008331 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 1232383008332 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232383008333 Walker A/P-loop; other site 1232383008334 ATP binding site [chemical binding]; other site 1232383008335 Q-loop/lid; other site 1232383008336 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1232383008337 ABC transporter signature motif; other site 1232383008338 Walker B; other site 1232383008339 D-loop; other site 1232383008340 H-loop/switch region; other site 1232383008341 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1232383008342 Walker A/P-loop; other site 1232383008343 ATP binding site [chemical binding]; other site 1232383008344 Q-loop/lid; other site 1232383008345 ABC transporter signature motif; other site 1232383008346 Walker B; other site 1232383008347 D-loop; other site 1232383008348 H-loop/switch region; other site 1232383008349 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1232383008350 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1232383008351 dimer interface [polypeptide binding]; other site 1232383008352 FMN binding site [chemical binding]; other site 1232383008353 NADPH bind site [chemical binding]; other site 1232383008354 Inosine-uridine nucleoside N-ribohydrolase [Nucleotide transport and metabolism]; Region: URH1; COG1957 1232383008355 active site 1232383008356 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1232383008357 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 1232383008358 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 1232383008359 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1232383008360 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1232383008361 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1232383008362 heme-binding site [chemical binding]; other site 1232383008363 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1232383008364 FAD binding pocket [chemical binding]; other site 1232383008365 FAD binding motif [chemical binding]; other site 1232383008366 phosphate binding motif [ion binding]; other site 1232383008367 beta-alpha-beta structure motif; other site 1232383008368 NAD binding pocket [chemical binding]; other site 1232383008369 Heme binding pocket [chemical binding]; other site 1232383008370 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1232383008371 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1232383008372 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1232383008373 CAT RNA binding domain; Region: CAT_RBD; smart01061 1232383008374 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1232383008375 PRD domain; Region: PRD; pfam00874 1232383008376 PRD domain; Region: PRD; pfam00874 1232383008377 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1232383008378 beta-galactosidase; Region: BGL; TIGR03356 1232383008379 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1232383008380 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1232383008381 active site turn [active] 1232383008382 phosphorylation site [posttranslational modification] 1232383008383 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1232383008384 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1232383008385 HPr interaction site; other site 1232383008386 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1232383008387 active site 1232383008388 phosphorylation site [posttranslational modification] 1232383008389 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 1232383008390 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1232383008391 intersubunit interface [polypeptide binding]; other site 1232383008392 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1232383008393 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1232383008394 ABC-ATPase subunit interface; other site 1232383008395 dimer interface [polypeptide binding]; other site 1232383008396 putative PBP binding regions; other site 1232383008397 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1232383008398 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1232383008399 ABC-ATPase subunit interface; other site 1232383008400 dimer interface [polypeptide binding]; other site 1232383008401 putative PBP binding regions; other site 1232383008402 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1232383008403 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1232383008404 Walker A/P-loop; other site 1232383008405 ATP binding site [chemical binding]; other site 1232383008406 Q-loop/lid; other site 1232383008407 ABC transporter signature motif; other site 1232383008408 Walker B; other site 1232383008409 D-loop; other site 1232383008410 H-loop/switch region; other site 1232383008411 aminotransferase AlaT; Validated; Region: PRK09265 1232383008412 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1232383008413 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232383008414 homodimer interface [polypeptide binding]; other site 1232383008415 catalytic residue [active] 1232383008416 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 1232383008417 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1232383008418 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1232383008419 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1232383008420 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1232383008421 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1232383008422 trimer interface [polypeptide binding]; other site 1232383008423 active site 1232383008424 Htaa; Region: HtaA; pfam04213 1232383008425 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 1232383008426 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1232383008427 VanW like protein; Region: VanW; pfam04294 1232383008428 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1232383008429 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1232383008430 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1232383008431 Ligand Binding Site [chemical binding]; other site 1232383008432 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 1232383008433 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1232383008434 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1232383008435 Helix-turn-helix domain; Region: HTH_38; pfam13936 1232383008436 Integrase core domain; Region: rve; pfam00665 1232383008437 hypothetical protein; Validated; Region: PRK09039 1232383008438 Integrase core domain; Region: rve; pfam00665 1232383008439 Integrase core domain; Region: rve_3; pfam13683 1232383008440 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1232383008441 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1232383008442 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1232383008443 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1232383008444 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232383008445 S-adenosylmethionine binding site [chemical binding]; other site 1232383008446 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1232383008447 active site 1232383008448 substrate-binding site [chemical binding]; other site 1232383008449 metal-binding site [ion binding] 1232383008450 GTP binding site [chemical binding]; other site 1232383008451 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1232383008452 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 1232383008453 gating phenylalanine in ion channel; other site 1232383008454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232383008455 S-adenosylmethionine binding site [chemical binding]; other site 1232383008456 LabA_like proteins; Region: LabA_like; cd06167 1232383008457 putative metal binding site [ion binding]; other site 1232383008458 MMPL family; Region: MMPL; pfam03176 1232383008459 MMPL family; Region: MMPL; pfam03176 1232383008460 Predicted integral membrane protein [Function unknown]; Region: COG0392 1232383008461 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1232383008462 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1232383008463 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1232383008464 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1232383008465 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1232383008466 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1232383008467 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1232383008468 active site 1232383008469 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1232383008470 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1232383008471 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1232383008472 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1232383008473 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1232383008474 acyl-activating enzyme (AAE) consensus motif; other site 1232383008475 active site 1232383008476 Cutinase; Region: Cutinase; pfam01083 1232383008477 Putative esterase; Region: Esterase; pfam00756 1232383008478 S-formylglutathione hydrolase; Region: PLN02442 1232383008479 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1232383008480 LGFP repeat; Region: LGFP; pfam08310 1232383008481 LGFP repeat; Region: LGFP; pfam08310 1232383008482 LGFP repeat; Region: LGFP; pfam08310 1232383008483 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1232383008484 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1232383008485 active site 1232383008486 Putative esterase; Region: Esterase; pfam00756 1232383008487 S-formylglutathione hydrolase; Region: PLN02442 1232383008488 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1232383008489 UbiA prenyltransferase family; Region: UbiA; pfam01040 1232383008490 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1232383008491 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1232383008492 active site 1232383008493 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1232383008494 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1232383008495 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1232383008496 active site 1232383008497 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1232383008498 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1232383008499 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1232383008500 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1232383008501 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1232383008502 UDP-galactopyranose mutase; Region: GLF; pfam03275 1232383008503 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1232383008504 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1232383008505 amidase catalytic site [active] 1232383008506 Zn binding residues [ion binding]; other site 1232383008507 substrate binding site [chemical binding]; other site 1232383008508 LGFP repeat; Region: LGFP; pfam08310 1232383008509 glycerol kinase; Provisional; Region: glpK; PRK00047 1232383008510 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 1232383008511 N- and C-terminal domain interface [polypeptide binding]; other site 1232383008512 active site 1232383008513 MgATP binding site [chemical binding]; other site 1232383008514 catalytic site [active] 1232383008515 metal binding site [ion binding]; metal-binding site 1232383008516 putative homotetramer interface [polypeptide binding]; other site 1232383008517 glycerol binding site [chemical binding]; other site 1232383008518 homodimer interface [polypeptide binding]; other site 1232383008519 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232383008520 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1232383008521 active site 1232383008522 motif I; other site 1232383008523 motif II; other site 1232383008524 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232383008525 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1232383008526 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1232383008527 putative acyl-acceptor binding pocket; other site 1232383008528 seryl-tRNA synthetase; Provisional; Region: PRK05431 1232383008529 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1232383008530 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1232383008531 dimer interface [polypeptide binding]; other site 1232383008532 active site 1232383008533 motif 1; other site 1232383008534 motif 2; other site 1232383008535 motif 3; other site 1232383008536 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1232383008537 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1232383008538 DNA-binding site [nucleotide binding]; DNA binding site 1232383008539 UTRA domain; Region: UTRA; pfam07702 1232383008540 Septum formation; Region: Septum_form; pfam13845 1232383008541 Septum formation; Region: Septum_form; pfam13845 1232383008542 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1232383008543 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1232383008544 catalytic core [active] 1232383008545 prephenate dehydratase; Provisional; Region: PRK11898 1232383008546 Prephenate dehydratase; Region: PDT; pfam00800 1232383008547 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1232383008548 putative L-Phe binding site [chemical binding]; other site 1232383008549 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1232383008550 Amidase; Region: Amidase; cl11426 1232383008551 CAAX protease self-immunity; Region: Abi; pfam02517 1232383008552 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1232383008553 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1232383008554 active site 1232383008555 catalytic site [active] 1232383008556 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1232383008557 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1232383008558 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1232383008559 active site 1232383008560 catalytic site [active] 1232383008561 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1232383008562 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 1232383008563 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1232383008564 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 1232383008565 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1232383008566 Integrase core domain; Region: rve; pfam00665 1232383008567 Integrase core domain; Region: rve_3; pfam13683 1232383008568 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1232383008569 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 1232383008570 putative active site [active] 1232383008571 catalytic site [active] 1232383008572 putative metal binding site [ion binding]; other site 1232383008573 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1232383008574 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1232383008575 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1232383008576 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1232383008577 DNA-binding site [nucleotide binding]; DNA binding site 1232383008578 FCD domain; Region: FCD; pfam07729 1232383008579 L-asparaginase II; Region: Asparaginase_II; pfam06089 1232383008580 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1232383008581 Aspartase; Region: Aspartase; cd01357 1232383008582 active sites [active] 1232383008583 tetramer interface [polypeptide binding]; other site 1232383008584 L-asparagine permease; Provisional; Region: PRK15049 1232383008585 pyruvate kinase; Provisional; Region: PRK14725 1232383008586 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 1232383008587 active site 1232383008588 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1232383008589 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1232383008590 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1232383008591 NAD binding site [chemical binding]; other site 1232383008592 dimer interface [polypeptide binding]; other site 1232383008593 substrate binding site [chemical binding]; other site 1232383008594 Predicted membrane protein [Function unknown]; Region: COG4425 1232383008595 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1232383008596 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1232383008597 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232383008598 motif II; other site 1232383008599 Predicted flavoprotein [General function prediction only]; Region: COG0431 1232383008600 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1232383008601 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1232383008602 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1232383008603 DNA-binding site [nucleotide binding]; DNA binding site 1232383008604 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1232383008605 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1232383008606 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1232383008607 active site 1232383008608 metal binding site [ion binding]; metal-binding site 1232383008609 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 1232383008610 metabolite-proton symporter; Region: 2A0106; TIGR00883 1232383008611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383008612 putative substrate translocation pore; other site 1232383008613 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1232383008614 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1232383008615 active site 1232383008616 substrate binding site [chemical binding]; other site 1232383008617 FMN binding site [chemical binding]; other site 1232383008618 putative catalytic residues [active] 1232383008619 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1232383008620 pentamer interface [polypeptide binding]; other site 1232383008621 dodecaamer interface [polypeptide binding]; other site 1232383008622 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1232383008623 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1232383008624 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1232383008625 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1232383008626 DNA-binding site [nucleotide binding]; DNA binding site 1232383008627 FCD domain; Region: FCD; pfam07729 1232383008628 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1232383008629 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1232383008630 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1232383008631 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1232383008632 aldehyde dehydrogenase family 7 member; Region: PLN02315 1232383008633 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1232383008634 tetrameric interface [polypeptide binding]; other site 1232383008635 NAD binding site [chemical binding]; other site 1232383008636 catalytic residues [active] 1232383008637 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1232383008638 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1232383008639 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1232383008640 NAD(P) binding site [chemical binding]; other site 1232383008641 Tubby C 2; Region: Tub_2; cl02043 1232383008642 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1232383008643 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1232383008644 metal binding site [ion binding]; metal-binding site 1232383008645 putative dimer interface [polypeptide binding]; other site 1232383008646 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1232383008647 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1232383008648 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1232383008649 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1232383008650 Integrase core domain; Region: rve; pfam00665 1232383008651 Integrase core domain; Region: rve_3; pfam13683 1232383008652 hypothetical protein; Validated; Region: PRK09039 1232383008653 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1232383008654 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1232383008655 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1232383008656 putative dimerization interface [polypeptide binding]; other site 1232383008657 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383008658 putative substrate translocation pore; other site 1232383008659 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1232383008660 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1232383008661 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 1232383008662 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1232383008663 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1232383008664 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232383008665 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232383008666 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1232383008667 classical (c) SDRs; Region: SDR_c; cd05233 1232383008668 NAD(P) binding site [chemical binding]; other site 1232383008669 active site 1232383008670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383008671 putative substrate translocation pore; other site 1232383008672 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1232383008673 MarR family; Region: MarR_2; pfam12802 1232383008674 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1232383008675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1232383008676 active site 1232383008677 phosphorylation site [posttranslational modification] 1232383008678 intermolecular recognition site; other site 1232383008679 dimerization interface [polypeptide binding]; other site 1232383008680 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1232383008681 DNA binding residues [nucleotide binding] 1232383008682 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1232383008683 Histidine kinase; Region: HisKA_3; pfam07730 1232383008684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232383008685 ATP binding site [chemical binding]; other site 1232383008686 Mg2+ binding site [ion binding]; other site 1232383008687 G-X-G motif; other site 1232383008688 Domain of unknown function (DUF2020); Region: DUF2020; pfam09449 1232383008689 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 1232383008690 active site 1232383008691 catalytic site [active] 1232383008692 putative inner membrane protein translocase component YidC; Validated; Region: PRK00247 1232383008693 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1232383008694 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1232383008695 Ligand Binding Site [chemical binding]; other site 1232383008696 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1232383008697 Ligand Binding Site [chemical binding]; other site 1232383008698 potential frameshift: common BLAST hit: gi|62391782|ref|YP_227184.1| alkanal monooxygenase subunit alpha 1232383008699 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1232383008700 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 1232383008701 probable active site [active] 1232383008702 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1232383008703 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1232383008704 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1232383008705 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 1232383008706 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1232383008707 putative ligand binding site [chemical binding]; other site 1232383008708 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1232383008709 MarR family; Region: MarR_2; pfam12802 1232383008710 Predicted transcriptional regulators [Transcription]; Region: COG1725 1232383008711 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1232383008712 DNA-binding site [nucleotide binding]; DNA binding site 1232383008713 LabA_like proteins; Region: LabA_like; cd06167 1232383008714 putative metal binding site [ion binding]; other site 1232383008715 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1232383008716 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1232383008717 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1232383008718 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1232383008719 catalytic residues [active] 1232383008720 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1232383008721 metal-binding site [ion binding] 1232383008722 benzoate transport; Region: 2A0115; TIGR00895 1232383008723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383008724 putative substrate translocation pore; other site 1232383008725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383008726 Predicted transcriptional regulators [Transcription]; Region: COG1695 1232383008727 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1232383008728 replicative DNA helicase; Provisional; Region: PRK05636 1232383008729 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1232383008730 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1232383008731 Walker A motif; other site 1232383008732 ATP binding site [chemical binding]; other site 1232383008733 Walker B motif; other site 1232383008734 DNA binding loops [nucleotide binding] 1232383008735 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1232383008736 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1232383008737 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1232383008738 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1232383008739 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1232383008740 dimer interface [polypeptide binding]; other site 1232383008741 ssDNA binding site [nucleotide binding]; other site 1232383008742 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1232383008743 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1232383008744 Predicted integral membrane protein [Function unknown]; Region: COG5650 1232383008745 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1232383008746 Transglycosylase; Region: Transgly; pfam00912 1232383008747 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1232383008748 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1232383008749 MarR family; Region: MarR; pfam01047 1232383008750 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1232383008751 Ligand Binding Site [chemical binding]; other site 1232383008752 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1232383008753 Ligand Binding Site [chemical binding]; other site 1232383008754 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1232383008755 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1232383008756 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1232383008757 active site residue [active] 1232383008758 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1232383008759 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1232383008760 FtsX-like permease family; Region: FtsX; pfam02687 1232383008761 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1232383008762 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1232383008763 Walker A/P-loop; other site 1232383008764 ATP binding site [chemical binding]; other site 1232383008765 Q-loop/lid; other site 1232383008766 ABC transporter signature motif; other site 1232383008767 Walker B; other site 1232383008768 D-loop; other site 1232383008769 H-loop/switch region; other site 1232383008770 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 1232383008771 HlyD family secretion protein; Region: HlyD_3; pfam13437 1232383008772 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1232383008773 inositol 1-phosphate synthase, Actinobacterial type; Region: mycothiol_INO1; TIGR03450 1232383008774 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 1232383008775 hypothetical protein; Provisional; Region: PRK13663 1232383008776 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1232383008777 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1232383008778 dimerization interface [polypeptide binding]; other site 1232383008779 DPS ferroxidase diiron center [ion binding]; other site 1232383008780 ion pore; other site 1232383008781 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1232383008782 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1232383008783 putative DNA binding site [nucleotide binding]; other site 1232383008784 catalytic residue [active] 1232383008785 putative H2TH interface [polypeptide binding]; other site 1232383008786 putative catalytic residues [active] 1232383008787 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1232383008788 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1232383008789 hypothetical protein; Reviewed; Region: PRK09588 1232383008790 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1232383008791 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1232383008792 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1232383008793 DNA binding site [nucleotide binding] 1232383008794 active site 1232383008795 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1232383008796 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1232383008797 putative NAD(P) binding site [chemical binding]; other site 1232383008798 dimer interface [polypeptide binding]; other site 1232383008799 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1232383008800 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1232383008801 intersubunit interface [polypeptide binding]; other site 1232383008802 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1232383008803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383008804 putative substrate translocation pore; other site 1232383008805 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1232383008806 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1232383008807 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1232383008808 putative NAD(P) binding site [chemical binding]; other site 1232383008809 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1232383008810 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1232383008811 N- and C-terminal domain interface [polypeptide binding]; other site 1232383008812 active site 1232383008813 catalytic site [active] 1232383008814 metal binding site [ion binding]; metal-binding site 1232383008815 carbohydrate binding site [chemical binding]; other site 1232383008816 ATP binding site [chemical binding]; other site 1232383008817 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 1232383008818 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 1232383008819 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1232383008820 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 1232383008821 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232383008822 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1232383008823 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1232383008824 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1232383008825 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 1232383008826 putative FMN binding site [chemical binding]; other site 1232383008827 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1232383008828 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1232383008829 HIGH motif; other site 1232383008830 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1232383008831 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1232383008832 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1232383008833 active site 1232383008834 KMSKS motif; other site 1232383008835 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1232383008836 tRNA binding surface [nucleotide binding]; other site 1232383008837 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1232383008838 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1232383008839 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1232383008840 non-specific DNA binding site [nucleotide binding]; other site 1232383008841 salt bridge; other site 1232383008842 sequence-specific DNA binding site [nucleotide binding]; other site 1232383008843 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 1232383008844 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1232383008845 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 1232383008846 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1232383008847 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1232383008848 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 1232383008849 Cupin domain; Region: Cupin_2; pfam07883 1232383008850 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1232383008851 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1232383008852 Bacterial transcriptional regulator; Region: IclR; pfam01614 1232383008853 benzoate transport; Region: 2A0115; TIGR00895 1232383008854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383008855 putative substrate translocation pore; other site 1232383008856 salicylate hydroxylase; Provisional; Region: PRK08163 1232383008857 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1232383008858 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1232383008859 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1232383008860 SdpI/YhfL protein family; Region: SdpI; pfam13630 1232383008861 Predicted integral membrane protein [Function unknown]; Region: COG5658 1232383008862 anthranilate synthase component I; Provisional; Region: PRK13564 1232383008863 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1232383008864 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1232383008865 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1232383008866 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1232383008867 glutamine binding [chemical binding]; other site 1232383008868 catalytic triad [active] 1232383008869 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1232383008870 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1232383008871 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1232383008872 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1232383008873 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1232383008874 active site 1232383008875 ribulose/triose binding site [chemical binding]; other site 1232383008876 phosphate binding site [ion binding]; other site 1232383008877 substrate (anthranilate) binding pocket [chemical binding]; other site 1232383008878 product (indole) binding pocket [chemical binding]; other site 1232383008879 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1232383008880 active site 1232383008881 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1232383008882 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1232383008883 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232383008884 catalytic residue [active] 1232383008885 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1232383008886 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1232383008887 substrate binding site [chemical binding]; other site 1232383008888 active site 1232383008889 catalytic residues [active] 1232383008890 heterodimer interface [polypeptide binding]; other site 1232383008891 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1232383008892 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1232383008893 active site 1232383008894 phosphorylation site [posttranslational modification] 1232383008895 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1232383008896 active site 1232383008897 P-loop; other site 1232383008898 phosphorylation site [posttranslational modification] 1232383008899 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1232383008900 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1232383008901 Walker A/P-loop; other site 1232383008902 ATP binding site [chemical binding]; other site 1232383008903 Q-loop/lid; other site 1232383008904 ABC transporter signature motif; other site 1232383008905 Walker B; other site 1232383008906 D-loop; other site 1232383008907 H-loop/switch region; other site 1232383008908 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1232383008909 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1232383008910 iron-sulfur cluster [ion binding]; other site 1232383008911 [2Fe-2S] cluster binding site [ion binding]; other site 1232383008912 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1232383008913 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1232383008914 active site 1232383008915 FMN binding site [chemical binding]; other site 1232383008916 substrate binding site [chemical binding]; other site 1232383008917 homotetramer interface [polypeptide binding]; other site 1232383008918 catalytic residue [active] 1232383008919 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1232383008920 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1232383008921 Uncharacterized conserved protein [Function unknown]; Region: COG3358 1232383008922 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1232383008923 putative DNA binding site [nucleotide binding]; other site 1232383008924 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1232383008925 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1232383008926 active site 1232383008927 FMN binding site [chemical binding]; other site 1232383008928 substrate binding site [chemical binding]; other site 1232383008929 homotetramer interface [polypeptide binding]; other site 1232383008930 catalytic residue [active] 1232383008931 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1232383008932 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1232383008933 NAD(P) binding site [chemical binding]; other site 1232383008934 putative active site [active] 1232383008935 short chain dehydrogenase; Provisional; Region: PRK08267 1232383008936 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232383008937 NAD(P) binding site [chemical binding]; other site 1232383008938 active site 1232383008939 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1232383008940 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1232383008941 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1232383008942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383008943 putative substrate translocation pore; other site 1232383008944 POT family; Region: PTR2; cl17359 1232383008945 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232383008946 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1232383008947 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 1232383008948 active site 1232383008949 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1232383008950 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 1232383008951 active site 1232383008952 dimer interface [polypeptide binding]; other site 1232383008953 metal binding site [ion binding]; metal-binding site 1232383008954 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1232383008955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383008956 putative substrate translocation pore; other site 1232383008957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383008958 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1232383008959 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1232383008960 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1232383008961 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1232383008962 Bacterial transcriptional regulator; Region: IclR; pfam01614 1232383008963 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1232383008964 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1232383008965 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1232383008966 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1232383008967 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1232383008968 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1232383008969 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1232383008970 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1232383008971 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1232383008972 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1232383008973 Lamin Tail Domain; Region: LTD; pfam00932 1232383008974 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 1232383008975 putative active site [active] 1232383008976 putative metal binding site [ion binding]; other site 1232383008977 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1232383008978 classical (c) SDRs; Region: SDR_c; cd05233 1232383008979 NAD(P) binding site [chemical binding]; other site 1232383008980 active site 1232383008981 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 1232383008982 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 1232383008983 acyl-activating enzyme (AAE) consensus motif; other site 1232383008984 putative AMP binding site [chemical binding]; other site 1232383008985 putative active site [active] 1232383008986 putative CoA binding site [chemical binding]; other site 1232383008987 benzoate transport; Region: 2A0115; TIGR00895 1232383008988 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383008989 putative substrate translocation pore; other site 1232383008990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383008991 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1232383008992 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1232383008993 Bacterial transcriptional regulator; Region: IclR; pfam01614 1232383008994 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1232383008995 active site 1232383008996 proline/glycine betaine transporter; Provisional; Region: PRK10642 1232383008997 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383008998 putative substrate translocation pore; other site 1232383008999 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1232383009000 active site 1232383009001 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1232383009002 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1232383009003 DNA-binding site [nucleotide binding]; DNA binding site 1232383009004 FCD domain; Region: FCD; pfam07729 1232383009005 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1232383009006 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1232383009007 NAD(P) binding site [chemical binding]; other site 1232383009008 homotetramer interface [polypeptide binding]; other site 1232383009009 homodimer interface [polypeptide binding]; other site 1232383009010 active site 1232383009011 acyl-CoA synthetase; Validated; Region: PRK06178 1232383009012 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232383009013 acyl-activating enzyme (AAE) consensus motif; other site 1232383009014 AMP binding site [chemical binding]; other site 1232383009015 active site 1232383009016 CoA binding site [chemical binding]; other site 1232383009017 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1232383009018 active site 1232383009019 catalytic site [active] 1232383009020 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1232383009021 putative active site [active] 1232383009022 putative catalytic site [active] 1232383009023 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 1232383009024 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1232383009025 dimer interface [polypeptide binding]; other site 1232383009026 active site 1232383009027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232383009028 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1232383009029 putative substrate translocation pore; other site 1232383009030 short chain dehydrogenase; Provisional; Region: PRK07577 1232383009031 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232383009032 NAD(P) binding site [chemical binding]; other site 1232383009033 active site 1232383009034 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129 1232383009035 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1232383009036 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1232383009037 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1232383009038 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1232383009039 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 1232383009040 homodimer interface [polypeptide binding]; other site 1232383009041 chemical substrate binding site [chemical binding]; other site 1232383009042 oligomer interface [polypeptide binding]; other site 1232383009043 metal binding site [ion binding]; metal-binding site 1232383009044 GIY-YIG domain of uncharacterized bacterial protein structurally related to COG3410; Region: GIY-YIG_COG3410; cd10439 1232383009045 GIY-YIG motif/motif A; other site 1232383009046 putative active site [active] 1232383009047 putative metal binding site [ion binding]; other site 1232383009048 AAA ATPase domain; Region: AAA_16; pfam13191 1232383009049 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 1232383009050 Uncharacterized conserved protein [Function unknown]; Region: COG3410 1232383009051 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1232383009052 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1232383009053 siderophore binding site; other site 1232383009054 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1232383009055 2-enoyl thioester reductase (ETR) like proteins, child 2; Region: ETR_like_2; cd08292 1232383009056 putative NAD(P) binding site [chemical binding]; other site 1232383009057 putative dimer interface [polypeptide binding]; other site 1232383009058 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 1232383009059 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1232383009060 substrate binding site [chemical binding]; other site 1232383009061 dimer interface [polypeptide binding]; other site 1232383009062 ATP binding site [chemical binding]; other site 1232383009063 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 1232383009064 metal-binding site [ion binding] 1232383009065 Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687 1232383009066 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1232383009067 hypothetical protein; Validated; Region: PRK00228 1232383009068 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1232383009069 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1232383009070 active site 1232383009071 NTP binding site [chemical binding]; other site 1232383009072 metal binding triad [ion binding]; metal-binding site 1232383009073 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1232383009074 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1232383009075 Zn2+ binding site [ion binding]; other site 1232383009076 Mg2+ binding site [ion binding]; other site 1232383009077 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1232383009078 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1232383009079 active site 1232383009080 Ap6A binding site [chemical binding]; other site 1232383009081 nudix motif; other site 1232383009082 metal binding site [ion binding]; metal-binding site 1232383009083 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1232383009084 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1232383009085 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1232383009086 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1232383009087 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1232383009088 DNA binding residues [nucleotide binding] 1232383009089 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1232383009090 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1232383009091 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232383009092 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1232383009093 catalytic residues [active] 1232383009094 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1232383009095 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1232383009096 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1232383009097 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1232383009098 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1232383009099 active site 1232383009100 metal binding site [ion binding]; metal-binding site 1232383009101 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1232383009102 ParB-like nuclease domain; Region: ParB; smart00470 1232383009103 KorB domain; Region: KorB; pfam08535 1232383009104 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1232383009105 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1232383009106 P-loop; other site 1232383009107 Magnesium ion binding site [ion binding]; other site 1232383009108 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1232383009109 Magnesium ion binding site [ion binding]; other site 1232383009110 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1232383009111 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1232383009112 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1232383009113 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 1232383009114 Haemolytic domain; Region: Haemolytic; pfam01809 1232383009115 ribonuclease P; Reviewed; Region: rnpA; PRK03459