-- dump date 20140619_051827 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1121362000001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121362000002 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1121362000003 Walker A motif; other site 1121362000004 ATP binding site [chemical binding]; other site 1121362000005 Walker B motif; other site 1121362000006 arginine finger; other site 1121362000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1121362000008 DnaA box-binding interface [nucleotide binding]; other site 1121362000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1121362000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1121362000011 putative DNA binding surface [nucleotide binding]; other site 1121362000012 dimer interface [polypeptide binding]; other site 1121362000013 beta-clamp/clamp loader binding surface; other site 1121362000014 beta-clamp/translesion DNA polymerase binding surface; other site 1121362000015 recF protein; Region: recf; TIGR00611 1121362000016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362000017 Walker A/P-loop; other site 1121362000018 ATP binding site [chemical binding]; other site 1121362000019 Q-loop/lid; other site 1121362000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362000021 ABC transporter signature motif; other site 1121362000022 Walker B; other site 1121362000023 D-loop; other site 1121362000024 H-loop/switch region; other site 1121362000025 Protein of unknown function (DUF721); Region: DUF721; cl02324 1121362000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1121362000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121362000028 ATP binding site [chemical binding]; other site 1121362000029 Mg2+ binding site [ion binding]; other site 1121362000030 G-X-G motif; other site 1121362000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1121362000032 anchoring element; other site 1121362000033 dimer interface [polypeptide binding]; other site 1121362000034 ATP binding site [chemical binding]; other site 1121362000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1121362000036 active site 1121362000037 putative metal-binding site [ion binding]; other site 1121362000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1121362000039 DNA gyrase subunit A; Validated; Region: PRK05560 1121362000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1121362000041 CAP-like domain; other site 1121362000042 active site 1121362000043 primary dimer interface [polypeptide binding]; other site 1121362000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1121362000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1121362000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1121362000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1121362000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1121362000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1121362000050 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1121362000051 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782 1121362000052 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1121362000053 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1121362000054 FAD binding site [chemical binding]; other site 1121362000055 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1121362000056 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1121362000057 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1121362000058 substrate binding site [chemical binding]; other site 1121362000059 THF binding site; other site 1121362000060 zinc-binding site [ion binding]; other site 1121362000061 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1121362000062 active site 1121362000063 putative septation inhibitor protein; Reviewed; Region: PRK00159 1121362000064 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1121362000065 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1121362000066 active site 1121362000067 ATP binding site [chemical binding]; other site 1121362000068 substrate binding site [chemical binding]; other site 1121362000069 activation loop (A-loop); other site 1121362000070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1121362000071 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1121362000072 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1121362000073 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1121362000074 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1121362000075 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1121362000076 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1121362000077 active site 1121362000078 ATP binding site [chemical binding]; other site 1121362000079 substrate binding site [chemical binding]; other site 1121362000080 activation loop (A-loop); other site 1121362000081 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1121362000082 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1121362000083 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1121362000084 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1121362000085 Protein phosphatase 2C; Region: PP2C; pfam00481 1121362000086 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1121362000087 active site 1121362000088 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1121362000089 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1121362000090 phosphopeptide binding site; other site 1121362000091 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1121362000092 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1121362000093 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1121362000094 phosphopeptide binding site; other site 1121362000095 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1121362000096 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1121362000097 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1121362000098 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1121362000099 AsnC family; Region: AsnC_trans_reg; pfam01037 1121362000100 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1121362000101 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1121362000102 metal binding site [ion binding]; metal-binding site 1121362000103 putative dimer interface [polypeptide binding]; other site 1121362000104 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 1121362000105 CHY zinc finger; Region: zf-CHY; pfam05495 1121362000106 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1121362000107 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 1121362000108 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1121362000109 putative NAD(P) binding site [chemical binding]; other site 1121362000110 substrate binding site [chemical binding]; other site 1121362000111 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1121362000112 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1121362000113 putative active site [active] 1121362000114 catalytic triad [active] 1121362000115 putative dimer interface [polypeptide binding]; other site 1121362000116 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1121362000117 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1121362000118 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1121362000119 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1121362000120 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1121362000121 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1121362000122 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1121362000123 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1121362000124 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1121362000125 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1121362000126 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1121362000127 active site residue [active] 1121362000128 potential frameshift: common BLAST hit: gi|389851345|ref|YP_006353580.1| Sortase-like protein 1121362000129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362000130 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121362000131 putative substrate translocation pore; other site 1121362000132 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1121362000133 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1121362000134 active site residue [active] 1121362000135 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1121362000136 active site residue [active] 1121362000137 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1121362000138 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1121362000139 putative homodimer interface [polypeptide binding]; other site 1121362000140 putative homotetramer interface [polypeptide binding]; other site 1121362000141 putative allosteric switch controlling residues; other site 1121362000142 putative metal binding site [ion binding]; other site 1121362000143 putative homodimer-homodimer interface [polypeptide binding]; other site 1121362000144 Domain of unknown function DUF302; Region: DUF302; cl01364 1121362000145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121362000146 S-adenosylmethionine binding site [chemical binding]; other site 1121362000147 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121362000148 dimerization interface [polypeptide binding]; other site 1121362000149 putative DNA binding site [nucleotide binding]; other site 1121362000150 putative Zn2+ binding site [ion binding]; other site 1121362000151 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1121362000152 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1121362000153 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1121362000154 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1121362000155 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1121362000156 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1121362000157 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1121362000158 dimerization interface [polypeptide binding]; other site 1121362000159 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1121362000160 Predicted flavoprotein [General function prediction only]; Region: COG0431 1121362000161 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1121362000162 Cation efflux family; Region: Cation_efflux; pfam01545 1121362000163 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 1121362000164 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1121362000165 putative metal binding site [ion binding]; other site 1121362000166 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1121362000167 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1121362000168 NAD binding site [chemical binding]; other site 1121362000169 catalytic Zn binding site [ion binding]; other site 1121362000170 structural Zn binding site [ion binding]; other site 1121362000171 biotin synthase; Validated; Region: PRK06256 1121362000172 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121362000173 FeS/SAM binding site; other site 1121362000174 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1121362000175 carboxylate-amine ligase; Provisional; Region: PRK13517 1121362000176 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1121362000177 DinB superfamily; Region: DinB_2; pfam12867 1121362000178 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1121362000179 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1121362000180 hypothetical protein; Provisional; Region: PRK06062 1121362000181 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1121362000182 inhibitor-cofactor binding pocket; inhibition site 1121362000183 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121362000184 catalytic residue [active] 1121362000185 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1121362000186 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1121362000187 active site 1121362000188 metal binding site [ion binding]; metal-binding site 1121362000189 Domain of unknown function (DUF4073); Region: DUF4073; pfam13285 1121362000190 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1121362000191 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1121362000192 classical (c) SDRs; Region: SDR_c; cd05233 1121362000193 NAD(P) binding site [chemical binding]; other site 1121362000194 active site 1121362000195 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1121362000196 Beta-lactamase; Region: Beta-lactamase; pfam00144 1121362000197 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1121362000198 Cytochrome P450; Region: p450; cl12078 1121362000199 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1121362000200 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1121362000201 FMN-binding pocket [chemical binding]; other site 1121362000202 flavin binding motif; other site 1121362000203 phosphate binding motif [ion binding]; other site 1121362000204 beta-alpha-beta structure motif; other site 1121362000205 NAD binding pocket [chemical binding]; other site 1121362000206 putative transposase OrfB; Reviewed; Region: PHA02517 1121362000207 HTH-like domain; Region: HTH_21; pfam13276 1121362000208 Integrase core domain; Region: rve; pfam00665 1121362000209 Integrase core domain; Region: rve_3; pfam13683 1121362000210 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1121362000211 Transposase; Region: HTH_Tnp_1; pfam01527 1121362000212 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1121362000213 catalytic loop [active] 1121362000214 iron binding site [ion binding]; other site 1121362000215 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1121362000216 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1121362000217 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1121362000218 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1121362000219 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1121362000220 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1121362000221 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1121362000222 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1121362000223 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1121362000224 NAD(P) binding site [chemical binding]; other site 1121362000225 metabolite-proton symporter; Region: 2A0106; TIGR00883 1121362000226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362000227 putative substrate translocation pore; other site 1121362000228 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1121362000229 GAF domain; Region: GAF; pfam01590 1121362000230 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1121362000231 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1121362000232 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121362000233 NAD(P) binding site [chemical binding]; other site 1121362000234 active site 1121362000235 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1121362000236 classical (c) SDRs; Region: SDR_c; cd05233 1121362000237 NAD(P) binding site [chemical binding]; other site 1121362000238 active site 1121362000239 succinic semialdehyde dehydrogenase; Region: PLN02278 1121362000240 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1121362000241 tetramerization interface [polypeptide binding]; other site 1121362000242 NAD(P) binding site [chemical binding]; other site 1121362000243 catalytic residues [active] 1121362000244 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121362000245 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121362000246 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1121362000247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362000248 putative substrate translocation pore; other site 1121362000249 POT family; Region: PTR2; cl17359 1121362000250 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 1121362000251 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 1121362000252 NAD+ binding site [chemical binding]; other site 1121362000253 substrate binding site [chemical binding]; other site 1121362000254 Zn binding site [ion binding]; other site 1121362000255 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1121362000256 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121362000257 non-specific DNA binding site [nucleotide binding]; other site 1121362000258 salt bridge; other site 1121362000259 sequence-specific DNA binding site [nucleotide binding]; other site 1121362000260 Predicted membrane protein [Function unknown]; Region: COG2323 1121362000261 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1121362000262 Lipase (class 2); Region: Lipase_2; pfam01674 1121362000263 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1121362000264 Ferritin-like domain; Region: Ferritin; pfam00210 1121362000265 ferroxidase diiron center [ion binding]; other site 1121362000266 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1121362000267 heme binding pocket [chemical binding]; other site 1121362000268 heme ligand [chemical binding]; other site 1121362000269 AMP nucleosidase; Provisional; Region: PRK08292 1121362000270 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1121362000271 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1121362000272 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1121362000273 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 1121362000274 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 1121362000275 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293; cl07913 1121362000276 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 1121362000277 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 1121362000278 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 1121362000279 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1121362000280 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 1121362000281 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 1121362000282 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 1121362000283 Malonate transporter MadL subunit; Region: MadL; cl04273 1121362000284 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1121362000285 Integrase core domain; Region: rve_3; pfam13683 1121362000286 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1121362000287 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1121362000288 active site 1121362000289 DNA binding site [nucleotide binding] 1121362000290 Int/Topo IB signature motif; other site 1121362000291 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1121362000292 active site 1121362000293 DNA binding site [nucleotide binding] 1121362000294 Int/Topo IB signature motif; other site 1121362000295 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1121362000296 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1121362000297 active site 1121362000298 DNA binding site [nucleotide binding] 1121362000299 Int/Topo IB signature motif; other site 1121362000300 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1121362000301 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1121362000302 DctM-like transporters; Region: DctM; pfam06808 1121362000303 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1121362000304 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1121362000305 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1121362000306 dimerization interface [polypeptide binding]; other site 1121362000307 substrate binding pocket [chemical binding]; other site 1121362000308 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 1121362000309 Helix-turn-helix domain; Region: HTH_18; pfam12833 1121362000310 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121362000311 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1121362000312 Zn binding site [ion binding]; other site 1121362000313 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1121362000314 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1121362000315 Zn binding site [ion binding]; other site 1121362000316 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1121362000317 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1121362000318 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1121362000319 active site 1121362000320 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1121362000321 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-2; cd12809 1121362000322 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1121362000323 catalytic site [active] 1121362000324 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1121362000325 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 1121362000326 active site 1121362000327 dimer interface [polypeptide binding]; other site 1121362000328 metal binding site [ion binding]; metal-binding site 1121362000329 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1121362000330 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 1121362000331 active site 1121362000332 FAD binding domain; Region: FAD_binding_3; pfam01494 1121362000333 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1121362000334 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1121362000335 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1121362000336 polyol permease family; Region: 2A0118; TIGR00897 1121362000337 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362000338 putative substrate translocation pore; other site 1121362000339 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1121362000340 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1121362000341 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1121362000342 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1121362000343 D-xylulose kinase; Region: XylB; TIGR01312 1121362000344 nucleotide binding site [chemical binding]; other site 1121362000345 short chain dehydrogenase; Provisional; Region: PRK12829 1121362000346 classical (c) SDRs; Region: SDR_c; cd05233 1121362000347 NAD(P) binding site [chemical binding]; other site 1121362000348 active site 1121362000349 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 1121362000350 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 1121362000351 acyl-activating enzyme (AAE) consensus motif; other site 1121362000352 putative AMP binding site [chemical binding]; other site 1121362000353 putative active site [active] 1121362000354 putative CoA binding site [chemical binding]; other site 1121362000355 benzoate transport; Region: 2A0115; TIGR00895 1121362000356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362000357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362000358 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1121362000359 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1121362000360 Bacterial transcriptional regulator; Region: IclR; pfam01614 1121362000361 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1121362000362 active site 1121362000363 benzoate transport; Region: 2A0115; TIGR00895 1121362000364 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362000365 putative substrate translocation pore; other site 1121362000366 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1121362000367 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1121362000368 FMN-binding pocket [chemical binding]; other site 1121362000369 flavin binding motif; other site 1121362000370 phosphate binding motif [ion binding]; other site 1121362000371 beta-alpha-beta structure motif; other site 1121362000372 NAD binding pocket [chemical binding]; other site 1121362000373 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1121362000374 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1121362000375 catalytic loop [active] 1121362000376 iron binding site [ion binding]; other site 1121362000377 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1121362000378 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1121362000379 iron-sulfur cluster [ion binding]; other site 1121362000380 [2Fe-2S] cluster binding site [ion binding]; other site 1121362000381 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 1121362000382 alpha subunit interface [polypeptide binding]; other site 1121362000383 active site 1121362000384 substrate binding site [chemical binding]; other site 1121362000385 Fe binding site [ion binding]; other site 1121362000386 Predicted transcriptional regulators [Transcription]; Region: COG1695 1121362000387 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1121362000388 Integrase core domain; Region: rve; pfam00665 1121362000389 Integrase core domain; Region: rve_3; pfam13683 1121362000390 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1121362000391 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1121362000392 Bacterial transcriptional regulator; Region: IclR; pfam01614 1121362000393 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1121362000394 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1121362000395 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1121362000396 dimerization interface [polypeptide binding]; other site 1121362000397 ligand binding site [chemical binding]; other site 1121362000398 NADP binding site [chemical binding]; other site 1121362000399 catalytic site [active] 1121362000400 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1121362000401 active site 1121362000402 catalytic residues [active] 1121362000403 metal binding site [ion binding]; metal-binding site 1121362000404 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1121362000405 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1121362000406 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1121362000407 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1121362000408 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1121362000409 tartrate dehydrogenase; Region: TTC; TIGR02089 1121362000410 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1121362000411 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1121362000412 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1121362000413 dimerization interface [polypeptide binding]; other site 1121362000414 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1121362000415 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121362000416 DNA-binding site [nucleotide binding]; DNA binding site 1121362000417 FCD domain; Region: FCD; pfam07729 1121362000418 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1121362000419 L-lactate permease; Region: Lactate_perm; cl00701 1121362000420 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1121362000421 Cysteine-rich domain; Region: CCG; pfam02754 1121362000422 Cysteine-rich domain; Region: CCG; pfam02754 1121362000423 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1121362000424 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1121362000425 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1121362000426 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 1121362000427 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 1121362000428 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1121362000429 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1121362000430 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1121362000431 putative NAD(P) binding site [chemical binding]; other site 1121362000432 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 1121362000433 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1121362000434 inhibitor-cofactor binding pocket; inhibition site 1121362000435 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121362000436 catalytic residue [active] 1121362000437 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1121362000438 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1121362000439 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1121362000440 active site 1121362000441 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1121362000442 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1121362000443 NAD(P) binding site [chemical binding]; other site 1121362000444 catalytic residues [active] 1121362000445 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1121362000446 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1121362000447 NAD(P) binding site [chemical binding]; other site 1121362000448 catalytic residues [active] 1121362000449 EamA-like transporter family; Region: EamA; pfam00892 1121362000450 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1121362000451 EamA-like transporter family; Region: EamA; pfam00892 1121362000452 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1121362000453 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1121362000454 putative di-iron ligands [ion binding]; other site 1121362000455 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1121362000456 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1121362000457 Protein of unknown function (DUF3024); Region: DUF3024; pfam11225 1121362000458 Uncharacterized conserved protein [Function unknown]; Region: COG4850 1121362000459 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 1121362000460 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1121362000461 Fic family protein [Function unknown]; Region: COG3177 1121362000462 Fic/DOC family; Region: Fic; pfam02661 1121362000463 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1121362000464 homotrimer interaction site [polypeptide binding]; other site 1121362000465 putative active site [active] 1121362000466 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1121362000467 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121362000468 Coenzyme A binding pocket [chemical binding]; other site 1121362000469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1121362000470 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1121362000471 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1121362000472 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1121362000473 dimerization interface [polypeptide binding]; other site 1121362000474 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1121362000475 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1121362000476 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1121362000477 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1121362000478 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1121362000479 active site 1121362000480 DNA binding site [nucleotide binding] 1121362000481 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1121362000482 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 1121362000483 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1121362000484 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1121362000485 trimer interface [polypeptide binding]; other site 1121362000486 putative metal binding site [ion binding]; other site 1121362000487 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1121362000488 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1121362000489 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1121362000490 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1121362000491 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1121362000492 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 1121362000493 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121362000494 putative DNA binding site [nucleotide binding]; other site 1121362000495 putative Zn2+ binding site [ion binding]; other site 1121362000496 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1121362000497 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1121362000498 nucleotide binding site [chemical binding]; other site 1121362000499 enterobactin exporter EntS; Provisional; Region: PRK10489 1121362000500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362000501 putative substrate translocation pore; other site 1121362000502 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1121362000503 Predicted membrane protein [Function unknown]; Region: COG2323 1121362000504 Predicted transcriptional regulators [Transcription]; Region: COG1695 1121362000505 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1121362000506 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1121362000507 conserved cys residue [active] 1121362000508 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121362000509 Zn2+ binding site [ion binding]; other site 1121362000510 Mg2+ binding site [ion binding]; other site 1121362000511 NAD-dependent deacetylase; Provisional; Region: PRK00481 1121362000512 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1121362000513 NAD+ binding site [chemical binding]; other site 1121362000514 substrate binding site [chemical binding]; other site 1121362000515 Zn binding site [ion binding]; other site 1121362000516 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121362000517 Coenzyme A binding pocket [chemical binding]; other site 1121362000518 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1121362000519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805 1121362000520 potential frameshift: common BLAST hit: gi|62391723|ref|YP_227125.1| membrane-associated PA-phosphatase related phosphoesterase 1121362000521 YCII-related domain; Region: YCII; cl00999 1121362000522 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1121362000523 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1121362000524 hypothetical protein; Provisional; Region: PRK10621 1121362000525 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1121362000526 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 1121362000527 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121362000528 ATP binding site [chemical binding]; other site 1121362000529 putative Mg++ binding site [ion binding]; other site 1121362000530 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121362000531 nucleotide binding region [chemical binding]; other site 1121362000532 Helicase associated domain (HA2); Region: HA2; pfam04408 1121362000533 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1121362000534 Maltose acetyltransferase; Region: Mac; pfam12464 1121362000535 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 1121362000536 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1121362000537 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1121362000538 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121362000539 NAD(P) binding site [chemical binding]; other site 1121362000540 active site 1121362000541 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1121362000542 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1121362000543 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1121362000544 RNA binding surface [nucleotide binding]; other site 1121362000545 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1121362000546 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1121362000547 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1121362000548 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cl01497 1121362000549 DNA binding site [nucleotide binding] 1121362000550 active site 1121362000551 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 1121362000552 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1121362000553 Ornithine cyclodeaminase/mu-crystallin family; Region: OCD_Mu_crystall; pfam02423 1121362000554 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1121362000555 DivIVA protein; Region: DivIVA; pfam05103 1121362000556 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1121362000557 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1121362000558 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121362000559 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121362000560 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1121362000561 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1121362000562 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1121362000563 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1121362000564 putative NAD(P) binding site [chemical binding]; other site 1121362000565 putative substrate binding site [chemical binding]; other site 1121362000566 catalytic Zn binding site [ion binding]; other site 1121362000567 structural Zn binding site [ion binding]; other site 1121362000568 dimer interface [polypeptide binding]; other site 1121362000569 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1121362000570 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1121362000571 catalytic residue [active] 1121362000572 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845 1121362000573 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1121362000574 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1121362000575 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1121362000576 short chain dehydrogenase; Provisional; Region: PRK06181 1121362000577 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121362000578 NAD(P) binding site [chemical binding]; other site 1121362000579 active site 1121362000580 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1121362000581 glycogen branching enzyme; Provisional; Region: PRK14705 1121362000582 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1121362000583 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1121362000584 tetrameric interface [polypeptide binding]; other site 1121362000585 NAD binding site [chemical binding]; other site 1121362000586 catalytic residues [active] 1121362000587 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1121362000588 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1121362000589 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1121362000590 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1121362000591 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1121362000592 dimerization interface [polypeptide binding]; other site 1121362000593 metabolite-proton symporter; Region: 2A0106; TIGR00883 1121362000594 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362000595 putative substrate translocation pore; other site 1121362000596 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1121362000597 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1121362000598 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1121362000599 active site 1121362000600 Zn binding site [ion binding]; other site 1121362000601 Protease prsW family; Region: PrsW-protease; pfam13367 1121362000602 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1121362000603 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1121362000604 active site 1121362000605 dimer interface [polypeptide binding]; other site 1121362000606 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1121362000607 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1121362000608 active site 1121362000609 FMN binding site [chemical binding]; other site 1121362000610 substrate binding site [chemical binding]; other site 1121362000611 3Fe-4S cluster binding site [ion binding]; other site 1121362000612 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1121362000613 domain interface; other site 1121362000614 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1121362000615 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121362000616 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1121362000617 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1121362000618 active site 1121362000619 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1121362000620 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 1121362000621 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 1121362000622 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1121362000623 classical (c) SDRs; Region: SDR_c; cd05233 1121362000624 NAD(P) binding site [chemical binding]; other site 1121362000625 active site 1121362000626 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1121362000627 FAD binding domain; Region: FAD_binding_4; pfam01565 1121362000628 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1121362000629 NAD synthetase; Provisional; Region: PRK13981 1121362000630 Predicted membrane protein [Function unknown]; Region: COG2246 1121362000631 GtrA-like protein; Region: GtrA; pfam04138 1121362000632 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1121362000633 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121362000634 active site 1121362000635 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1121362000636 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1121362000637 putative active site [active] 1121362000638 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1121362000639 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1121362000640 Walker A/P-loop; other site 1121362000641 ATP binding site [chemical binding]; other site 1121362000642 Q-loop/lid; other site 1121362000643 ABC transporter signature motif; other site 1121362000644 Walker B; other site 1121362000645 D-loop; other site 1121362000646 H-loop/switch region; other site 1121362000647 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1121362000648 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1121362000649 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1121362000650 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1121362000651 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121362000652 catalytic residue [active] 1121362000653 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1121362000654 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1121362000655 NAD(P) binding site [chemical binding]; other site 1121362000656 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 1121362000657 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK05597 1121362000658 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1121362000659 ATP binding site [chemical binding]; other site 1121362000660 substrate interface [chemical binding]; other site 1121362000661 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1121362000662 active site residue [active] 1121362000663 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1121362000664 MoaE homodimer interface [polypeptide binding]; other site 1121362000665 MoaD interaction [polypeptide binding]; other site 1121362000666 active site residues [active] 1121362000667 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1121362000668 MPT binding site; other site 1121362000669 trimer interface [polypeptide binding]; other site 1121362000670 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1121362000671 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1121362000672 dimer interface [polypeptide binding]; other site 1121362000673 putative functional site; other site 1121362000674 putative MPT binding site; other site 1121362000675 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1121362000676 MoaE interaction surface [polypeptide binding]; other site 1121362000677 MoeB interaction surface [polypeptide binding]; other site 1121362000678 thiocarboxylated glycine; other site 1121362000679 Predicted membrane protein [Function unknown]; Region: COG1950 1121362000680 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1121362000681 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121362000682 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121362000683 homodimer interface [polypeptide binding]; other site 1121362000684 catalytic residue [active] 1121362000685 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1121362000686 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1121362000687 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1121362000688 Divalent cation transporter; Region: MgtE; cl00786 1121362000689 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1121362000690 transmembrane helices; other site 1121362000691 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1121362000692 prephenate dehydrogenase; Validated; Region: PRK06545 1121362000693 prephenate dehydrogenase; Validated; Region: PRK08507 1121362000694 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1121362000695 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1121362000696 nucleoside/Zn binding site; other site 1121362000697 dimer interface [polypeptide binding]; other site 1121362000698 catalytic motif [active] 1121362000699 CsbD-like; Region: CsbD; pfam05532 1121362000700 MMPL family; Region: MMPL; pfam03176 1121362000701 MMPL family; Region: MMPL; pfam03176 1121362000702 Ion channel; Region: Ion_trans_2; pfam07885 1121362000703 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1121362000704 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1121362000705 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1121362000706 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121362000707 NAD(P) binding site [chemical binding]; other site 1121362000708 active site 1121362000709 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1121362000710 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1121362000711 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1121362000712 active site 1121362000713 HIGH motif; other site 1121362000714 nucleotide binding site [chemical binding]; other site 1121362000715 active site 1121362000716 KMSKS motif; other site 1121362000717 hydroperoxidase II; Provisional; Region: katE; PRK11249 1121362000718 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1121362000719 heme binding pocket [chemical binding]; other site 1121362000720 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1121362000721 domain interactions; other site 1121362000722 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1121362000723 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1121362000724 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121362000725 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121362000726 homodimer interface [polypeptide binding]; other site 1121362000727 catalytic residue [active] 1121362000728 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1121362000729 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121362000730 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1121362000731 Walker A motif; other site 1121362000732 ATP binding site [chemical binding]; other site 1121362000733 Walker B motif; other site 1121362000734 arginine finger; other site 1121362000735 hypothetical protein; Validated; Region: PRK00153 1121362000736 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1121362000737 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1121362000738 dimerization interface [polypeptide binding]; other site 1121362000739 DPS ferroxidase diiron center [ion binding]; other site 1121362000740 ion pore; other site 1121362000741 recombination protein RecR; Reviewed; Region: recR; PRK00076 1121362000742 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 1121362000743 RecR protein; Region: RecR; pfam02132 1121362000744 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1121362000745 putative active site [active] 1121362000746 putative metal-binding site [ion binding]; other site 1121362000747 tetramer interface [polypeptide binding]; other site 1121362000748 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 1121362000749 Hemerythrin-like domain; Region: Hr-like; cd12108 1121362000750 Fe binding site [ion binding]; other site 1121362000751 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1121362000752 Cation efflux family; Region: Cation_efflux; pfam01545 1121362000753 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 1121362000754 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121362000755 substrate binding pocket [chemical binding]; other site 1121362000756 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1121362000757 catalytic triad [active] 1121362000758 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1121362000759 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1121362000760 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1121362000761 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1121362000762 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1121362000763 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1121362000764 active site 1121362000765 catalytic tetrad [active] 1121362000766 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 1121362000767 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1121362000768 active site 1121362000769 catalytic site [active] 1121362000770 substrate binding site [chemical binding]; other site 1121362000771 Domain of unknown function (DUF3806); Region: DUF3806; pfam12713 1121362000772 YrhK-like protein; Region: YrhK; pfam14145 1121362000773 2-isopropylmalate synthase; Validated; Region: PRK03739 1121362000774 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1121362000775 active site 1121362000776 catalytic residues [active] 1121362000777 metal binding site [ion binding]; metal-binding site 1121362000778 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1121362000779 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188 1121362000780 aspartate kinase; Reviewed; Region: PRK06635 1121362000781 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1121362000782 putative nucleotide binding site [chemical binding]; other site 1121362000783 putative catalytic residues [active] 1121362000784 putative Mg ion binding site [ion binding]; other site 1121362000785 putative aspartate binding site [chemical binding]; other site 1121362000786 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1121362000787 putative allosteric regulatory site; other site 1121362000788 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1121362000789 putative allosteric regulatory residue; other site 1121362000790 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1121362000791 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1121362000792 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1121362000793 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1121362000794 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1121362000795 RNA polymerase sigma factor; Provisional; Region: PRK12535 1121362000796 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121362000797 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121362000798 DNA binding residues [nucleotide binding] 1121362000799 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1121362000800 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1121362000801 tetramer interface [polypeptide binding]; other site 1121362000802 heme binding pocket [chemical binding]; other site 1121362000803 NADPH binding site [chemical binding]; other site 1121362000804 Predicted membrane protein [Function unknown]; Region: COG1511 1121362000805 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 1121362000806 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1121362000807 active site 1121362000808 metal binding site [ion binding]; metal-binding site 1121362000809 Yqey-like protein; Region: YqeY; pfam09424 1121362000810 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1121362000811 Transglycosylase; Region: Transgly; pfam00912 1121362000812 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1121362000813 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1121362000814 Transcription factor WhiB; Region: Whib; pfam02467 1121362000815 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1121362000816 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1121362000817 homotrimer interaction site [polypeptide binding]; other site 1121362000818 putative active site [active] 1121362000819 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1121362000820 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1121362000821 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1121362000822 ligand binding site [chemical binding]; other site 1121362000823 flexible hinge region; other site 1121362000824 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1121362000825 putative switch regulator; other site 1121362000826 non-specific DNA interactions [nucleotide binding]; other site 1121362000827 DNA binding site [nucleotide binding] 1121362000828 sequence specific DNA binding site [nucleotide binding]; other site 1121362000829 putative cAMP binding site [chemical binding]; other site 1121362000830 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1121362000831 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1121362000832 minor groove reading motif; other site 1121362000833 helix-hairpin-helix signature motif; other site 1121362000834 substrate binding pocket [chemical binding]; other site 1121362000835 active site 1121362000836 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1121362000837 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1121362000838 catalytic residues [active] 1121362000839 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1121362000840 putative active site [active] 1121362000841 putative CoA binding site [chemical binding]; other site 1121362000842 nudix motif; other site 1121362000843 metal binding site [ion binding]; metal-binding site 1121362000844 Colicin V production protein; Region: Colicin_V; pfam02674 1121362000845 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1121362000846 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1121362000847 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1121362000848 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1121362000849 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1121362000850 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1121362000851 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1121362000852 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1121362000853 Type II/IV secretion system protein; Region: T2SE; pfam00437 1121362000854 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1121362000855 ATP binding site [chemical binding]; other site 1121362000856 Walker A motif; other site 1121362000857 hexamer interface [polypeptide binding]; other site 1121362000858 Walker B motif; other site 1121362000859 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1121362000860 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1121362000861 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1121362000862 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121362000863 ATP binding site [chemical binding]; other site 1121362000864 putative Mg++ binding site [ion binding]; other site 1121362000865 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1121362000866 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1121362000867 DNA-binding site [nucleotide binding]; DNA binding site 1121362000868 RNA-binding motif; other site 1121362000869 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 1121362000870 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 1121362000871 active site 1121362000872 DNA binding site [nucleotide binding] 1121362000873 Int/Topo IB signature motif; other site 1121362000874 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1121362000875 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1121362000876 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1121362000877 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1121362000878 putative active site [active] 1121362000879 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1121362000880 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1121362000881 active site 1121362000882 interdomain interaction site; other site 1121362000883 putative metal-binding site [ion binding]; other site 1121362000884 nucleotide binding site [chemical binding]; other site 1121362000885 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1121362000886 domain I; other site 1121362000887 phosphate binding site [ion binding]; other site 1121362000888 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1121362000889 domain II; other site 1121362000890 domain III; other site 1121362000891 nucleotide binding site [chemical binding]; other site 1121362000892 DNA binding groove [nucleotide binding] 1121362000893 catalytic site [active] 1121362000894 domain IV; other site 1121362000895 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1121362000896 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1121362000897 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1121362000898 putative monooxygenase; Provisional; Region: PRK11118 1121362000899 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1121362000900 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1121362000901 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1121362000902 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1121362000903 Predicted membrane protein [Function unknown]; Region: COG2364 1121362000904 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1121362000905 Predicted membrane protein [Function unknown]; Region: COG2364 1121362000906 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121362000907 dimerization interface [polypeptide binding]; other site 1121362000908 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1121362000909 cyclase homology domain; Region: CHD; cd07302 1121362000910 nucleotidyl binding site; other site 1121362000911 metal binding site [ion binding]; metal-binding site 1121362000912 dimer interface [polypeptide binding]; other site 1121362000913 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1121362000914 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1121362000915 acyl-CoA synthetase; Validated; Region: PRK07788 1121362000916 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121362000917 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121362000918 AMP binding site [chemical binding]; other site 1121362000919 active site 1121362000920 acyl-activating enzyme (AAE) consensus motif; other site 1121362000921 CoA binding site [chemical binding]; other site 1121362000922 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1121362000923 active site 1121362000924 catalytic triad [active] 1121362000925 oxyanion hole [active] 1121362000926 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1121362000927 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1121362000928 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1121362000929 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1121362000930 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1121362000931 NAD binding site [chemical binding]; other site 1121362000932 catalytic Zn binding site [ion binding]; other site 1121362000933 substrate binding site [chemical binding]; other site 1121362000934 structural Zn binding site [ion binding]; other site 1121362000935 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1121362000936 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1121362000937 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121362000938 NAD(P) binding site [chemical binding]; other site 1121362000939 active site 1121362000940 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 1121362000941 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1121362000942 Ligand binding site; other site 1121362000943 Putative Catalytic site; other site 1121362000944 DXD motif; other site 1121362000945 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121362000946 active site 1121362000947 Peptidase family M1; Region: Peptidase_M1; pfam01433 1121362000948 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1121362000949 Zn binding site [ion binding]; other site 1121362000950 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1121362000951 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1121362000952 Putative esterase; Region: Esterase; pfam00756 1121362000953 Putative esterase; Region: Esterase; pfam00756 1121362000954 Predicted esterase [General function prediction only]; Region: COG0627 1121362000955 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1121362000956 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1121362000957 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121362000958 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1121362000959 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1121362000960 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121362000961 non-specific DNA binding site [nucleotide binding]; other site 1121362000962 salt bridge; other site 1121362000963 sequence-specific DNA binding site [nucleotide binding]; other site 1121362000964 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1121362000965 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1121362000966 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1121362000967 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1121362000968 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 1121362000969 putative Iron-sulfur protein interface [polypeptide binding]; other site 1121362000970 proximal heme binding site [chemical binding]; other site 1121362000971 distal heme binding site [chemical binding]; other site 1121362000972 putative dimer interface [polypeptide binding]; other site 1121362000973 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 1121362000974 L-aspartate oxidase; Provisional; Region: PRK06175 1121362000975 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1121362000976 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 1121362000977 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1121362000978 Predicted membrane protein [Function unknown]; Region: COG2733 1121362000979 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1121362000980 Class I aldolases; Region: Aldolase_Class_I; cl17187 1121362000981 catalytic residue [active] 1121362000982 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1121362000983 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1121362000984 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1121362000985 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1121362000986 RDD family; Region: RDD; pfam06271 1121362000987 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 1121362000988 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1121362000989 acyl-activating enzyme (AAE) consensus motif; other site 1121362000990 putative AMP binding site [chemical binding]; other site 1121362000991 putative active site [active] 1121362000992 putative CoA binding site [chemical binding]; other site 1121362000993 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1121362000994 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1121362000995 putative ADP-binding pocket [chemical binding]; other site 1121362000996 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1121362000997 catalytic core [active] 1121362000998 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1121362000999 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1121362001000 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121362001001 dimer interface [polypeptide binding]; other site 1121362001002 phosphorylation site [posttranslational modification] 1121362001003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121362001004 ATP binding site [chemical binding]; other site 1121362001005 Mg2+ binding site [ion binding]; other site 1121362001006 G-X-G motif; other site 1121362001007 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121362001008 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121362001009 active site 1121362001010 phosphorylation site [posttranslational modification] 1121362001011 intermolecular recognition site; other site 1121362001012 dimerization interface [polypeptide binding]; other site 1121362001013 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121362001014 DNA binding site [nucleotide binding] 1121362001015 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1121362001016 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1121362001017 FtsX-like permease family; Region: FtsX; pfam02687 1121362001018 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1121362001019 FtsX-like permease family; Region: FtsX; pfam02687 1121362001020 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1121362001021 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1121362001022 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1121362001023 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1121362001024 DNA binding domain, excisionase family; Region: excise; TIGR01764 1121362001025 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1121362001026 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121362001027 motif II; other site 1121362001028 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1121362001029 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1121362001030 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1121362001031 tRNA; other site 1121362001032 putative tRNA binding site [nucleotide binding]; other site 1121362001033 putative NADP binding site [chemical binding]; other site 1121362001034 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1121362001035 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1121362001036 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1121362001037 domain interfaces; other site 1121362001038 active site 1121362001039 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1121362001040 active site 1121362001041 homodimer interface [polypeptide binding]; other site 1121362001042 SAM binding site [chemical binding]; other site 1121362001043 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1121362001044 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1121362001045 active site 1121362001046 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1121362001047 dimer interface [polypeptide binding]; other site 1121362001048 active site 1121362001049 Schiff base residues; other site 1121362001050 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1121362001051 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1121362001052 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1121362001053 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1121362001054 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1121362001055 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1121362001056 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1121362001057 Walker A/P-loop; other site 1121362001058 ATP binding site [chemical binding]; other site 1121362001059 Q-loop/lid; other site 1121362001060 ABC transporter signature motif; other site 1121362001061 Walker B; other site 1121362001062 D-loop; other site 1121362001063 H-loop/switch region; other site 1121362001064 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1121362001065 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1121362001066 substrate binding site [chemical binding]; other site 1121362001067 active site 1121362001068 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1121362001069 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121362001070 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1121362001071 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1121362001072 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1121362001073 inhibitor-cofactor binding pocket; inhibition site 1121362001074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121362001075 catalytic residue [active] 1121362001076 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1121362001077 catalytic core [active] 1121362001078 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1121362001079 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1121362001080 catalytic residues [active] 1121362001081 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1121362001082 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1121362001083 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1121362001084 ResB-like family; Region: ResB; pfam05140 1121362001085 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1121362001086 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1121362001087 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121362001088 motif II; other site 1121362001089 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1121362001090 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1121362001091 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1121362001092 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1121362001093 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121362001094 sequence-specific DNA binding site [nucleotide binding]; other site 1121362001095 salt bridge; other site 1121362001096 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1121362001097 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1121362001098 FMN binding site [chemical binding]; other site 1121362001099 active site 1121362001100 substrate binding site [chemical binding]; other site 1121362001101 catalytic residue [active] 1121362001102 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1121362001103 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1121362001104 NAD binding site [chemical binding]; other site 1121362001105 substrate binding site [chemical binding]; other site 1121362001106 homodimer interface [polypeptide binding]; other site 1121362001107 active site 1121362001108 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1121362001109 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1121362001110 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1121362001111 substrate binding site; other site 1121362001112 tetramer interface; other site 1121362001113 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 1121362001114 Predicted permeases [General function prediction only]; Region: COG0679 1121362001115 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1121362001116 UbiA prenyltransferase family; Region: UbiA; pfam01040 1121362001117 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1121362001118 active site 1121362001119 homotetramer interface [polypeptide binding]; other site 1121362001120 homodimer interface [polypeptide binding]; other site 1121362001121 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 1121362001122 active site 1121362001123 catalytic site [active] 1121362001124 Zn binding site [ion binding]; other site 1121362001125 tetramer interface [polypeptide binding]; other site 1121362001126 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1121362001127 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1121362001128 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1121362001129 active site 1121362001130 catalytic tetrad [active] 1121362001131 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1121362001132 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121362001133 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1121362001134 acyl-activating enzyme (AAE) consensus motif; other site 1121362001135 AMP binding site [chemical binding]; other site 1121362001136 active site 1121362001137 CoA binding site [chemical binding]; other site 1121362001138 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1121362001139 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1121362001140 substrate binding site [chemical binding]; other site 1121362001141 oxyanion hole (OAH) forming residues; other site 1121362001142 trimer interface [polypeptide binding]; other site 1121362001143 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1121362001144 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1121362001145 aromatic arch; other site 1121362001146 DCoH dimer interaction site [polypeptide binding]; other site 1121362001147 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1121362001148 DCoH tetramer interaction site [polypeptide binding]; other site 1121362001149 substrate binding site [chemical binding]; other site 1121362001150 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 1121362001151 catalytic triad [active] 1121362001152 active site nucleophile [active] 1121362001153 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1121362001154 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1121362001155 active site 1121362001156 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 1121362001157 putative FMN binding site [chemical binding]; other site 1121362001158 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1121362001159 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1121362001160 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1121362001161 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362001162 ABC transporter signature motif; other site 1121362001163 Walker B; other site 1121362001164 D-loop; other site 1121362001165 H-loop/switch region; other site 1121362001166 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362001167 Walker A/P-loop; other site 1121362001168 ATP binding site [chemical binding]; other site 1121362001169 Q-loop/lid; other site 1121362001170 ABC transporter signature motif; other site 1121362001171 Walker B; other site 1121362001172 D-loop; other site 1121362001173 H-loop/switch region; other site 1121362001174 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1121362001175 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1121362001176 dimer interface [polypeptide binding]; other site 1121362001177 tetramer interface [polypeptide binding]; other site 1121362001178 PYR/PP interface [polypeptide binding]; other site 1121362001179 TPP binding site [chemical binding]; other site 1121362001180 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1121362001181 TPP-binding site; other site 1121362001182 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1121362001183 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121362001184 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1121362001185 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121362001186 S-adenosylmethionine binding site [chemical binding]; other site 1121362001187 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1121362001188 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1121362001189 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1121362001190 substrate binding pocket [chemical binding]; other site 1121362001191 chain length determination region; other site 1121362001192 substrate-Mg2+ binding site; other site 1121362001193 catalytic residues [active] 1121362001194 aspartate-rich region 1; other site 1121362001195 active site lid residues [active] 1121362001196 aspartate-rich region 2; other site 1121362001197 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1121362001198 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1121362001199 substrate binding site [chemical binding]; other site 1121362001200 ATP binding site [chemical binding]; other site 1121362001201 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1121362001202 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1121362001203 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1121362001204 putative homodimer interface [polypeptide binding]; other site 1121362001205 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1121362001206 heterodimer interface [polypeptide binding]; other site 1121362001207 homodimer interface [polypeptide binding]; other site 1121362001208 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1121362001209 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1121362001210 23S rRNA interface [nucleotide binding]; other site 1121362001211 L7/L12 interface [polypeptide binding]; other site 1121362001212 putative thiostrepton binding site; other site 1121362001213 L25 interface [polypeptide binding]; other site 1121362001214 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1121362001215 mRNA/rRNA interface [nucleotide binding]; other site 1121362001216 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1121362001217 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121362001218 Protein of unknown function (DUF541); Region: SIMPL; cl01077 1121362001219 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1121362001220 23S rRNA interface [nucleotide binding]; other site 1121362001221 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1121362001222 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1121362001223 core dimer interface [polypeptide binding]; other site 1121362001224 peripheral dimer interface [polypeptide binding]; other site 1121362001225 L10 interface [polypeptide binding]; other site 1121362001226 L11 interface [polypeptide binding]; other site 1121362001227 putative EF-Tu interaction site [polypeptide binding]; other site 1121362001228 putative EF-G interaction site [polypeptide binding]; other site 1121362001229 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1121362001230 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1121362001231 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1121362001232 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1121362001233 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1121362001234 RPB1 interaction site [polypeptide binding]; other site 1121362001235 RPB10 interaction site [polypeptide binding]; other site 1121362001236 RPB11 interaction site [polypeptide binding]; other site 1121362001237 RPB3 interaction site [polypeptide binding]; other site 1121362001238 RPB12 interaction site [polypeptide binding]; other site 1121362001239 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1121362001240 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1121362001241 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1121362001242 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1121362001243 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1121362001244 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1121362001245 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1121362001246 G-loop; other site 1121362001247 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1121362001248 DNA binding site [nucleotide binding] 1121362001249 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1121362001250 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1121362001251 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1121362001252 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1121362001253 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1121362001254 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1121362001255 S17 interaction site [polypeptide binding]; other site 1121362001256 S8 interaction site; other site 1121362001257 16S rRNA interaction site [nucleotide binding]; other site 1121362001258 streptomycin interaction site [chemical binding]; other site 1121362001259 23S rRNA interaction site [nucleotide binding]; other site 1121362001260 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1121362001261 30S ribosomal protein S7; Validated; Region: PRK05302 1121362001262 elongation factor G; Reviewed; Region: PRK00007 1121362001263 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1121362001264 G1 box; other site 1121362001265 putative GEF interaction site [polypeptide binding]; other site 1121362001266 GTP/Mg2+ binding site [chemical binding]; other site 1121362001267 Switch I region; other site 1121362001268 G2 box; other site 1121362001269 G3 box; other site 1121362001270 Switch II region; other site 1121362001271 G4 box; other site 1121362001272 G5 box; other site 1121362001273 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1121362001274 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1121362001275 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1121362001276 elongation factor Tu; Reviewed; Region: PRK00049 1121362001277 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1121362001278 G1 box; other site 1121362001279 GEF interaction site [polypeptide binding]; other site 1121362001280 GTP/Mg2+ binding site [chemical binding]; other site 1121362001281 Switch I region; other site 1121362001282 G2 box; other site 1121362001283 G3 box; other site 1121362001284 Switch II region; other site 1121362001285 G4 box; other site 1121362001286 G5 box; other site 1121362001287 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1121362001288 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1121362001289 Antibiotic Binding Site [chemical binding]; other site 1121362001290 Asp23 family; Region: Asp23; pfam03780 1121362001291 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1121362001292 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1121362001293 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1121362001294 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1121362001295 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1121362001296 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1121362001297 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1121362001298 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1121362001299 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1121362001300 putative translocon binding site; other site 1121362001301 protein-rRNA interface [nucleotide binding]; other site 1121362001302 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1121362001303 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1121362001304 G-X-X-G motif; other site 1121362001305 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1121362001306 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1121362001307 23S rRNA interface [nucleotide binding]; other site 1121362001308 5S rRNA interface [nucleotide binding]; other site 1121362001309 putative antibiotic binding site [chemical binding]; other site 1121362001310 L25 interface [polypeptide binding]; other site 1121362001311 L27 interface [polypeptide binding]; other site 1121362001312 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1121362001313 putative translocon interaction site; other site 1121362001314 23S rRNA interface [nucleotide binding]; other site 1121362001315 signal recognition particle (SRP54) interaction site; other site 1121362001316 L23 interface [polypeptide binding]; other site 1121362001317 trigger factor interaction site; other site 1121362001318 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1121362001319 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1121362001320 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1121362001321 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1121362001322 IucA / IucC family; Region: IucA_IucC; pfam04183 1121362001323 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1121362001324 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 1121362001325 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1121362001326 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121362001327 catalytic residue [active] 1121362001328 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1121362001329 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1121362001330 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1121362001331 RNA binding site [nucleotide binding]; other site 1121362001332 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1121362001333 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1121362001334 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1121362001335 BCCT family transporter; Region: BCCT; cl00569 1121362001336 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1121362001337 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1121362001338 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1121362001339 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1121362001340 active site 1121362001341 catalytic tetrad [active] 1121362001342 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 1121362001343 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1121362001344 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1121362001345 metal binding site [ion binding]; metal-binding site 1121362001346 putative dimer interface [polypeptide binding]; other site 1121362001347 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1121362001348 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1121362001349 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1121362001350 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1121362001351 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1121362001352 23S rRNA interface [nucleotide binding]; other site 1121362001353 L21e interface [polypeptide binding]; other site 1121362001354 5S rRNA interface [nucleotide binding]; other site 1121362001355 L27 interface [polypeptide binding]; other site 1121362001356 L5 interface [polypeptide binding]; other site 1121362001357 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1121362001358 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1121362001359 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1121362001360 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1121362001361 23S rRNA binding site [nucleotide binding]; other site 1121362001362 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1121362001363 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1121362001364 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1121362001365 NAD(P) binding site [chemical binding]; other site 1121362001366 catalytic residues [active] 1121362001367 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121362001368 Zn2+ binding site [ion binding]; other site 1121362001369 Mg2+ binding site [ion binding]; other site 1121362001370 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1121362001371 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121362001372 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1121362001373 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1121362001374 catalytic loop [active] 1121362001375 iron binding site [ion binding]; other site 1121362001376 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1121362001377 classical (c) SDRs; Region: SDR_c; cd05233 1121362001378 NAD(P) binding site [chemical binding]; other site 1121362001379 active site 1121362001380 hypothetical protein; Provisional; Region: PRK08296 1121362001381 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1121362001382 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1121362001383 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1121362001384 Cytochrome P450; Region: p450; cl12078 1121362001385 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1121362001386 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1121362001387 Bacterial transcriptional regulator; Region: IclR; pfam01614 1121362001388 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1121362001389 SecY translocase; Region: SecY; pfam00344 1121362001390 adenylate kinase; Reviewed; Region: adk; PRK00279 1121362001391 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1121362001392 AMP-binding site [chemical binding]; other site 1121362001393 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1121362001394 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1121362001395 active site 1121362001396 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1121362001397 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1121362001398 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1121362001399 rRNA binding site [nucleotide binding]; other site 1121362001400 predicted 30S ribosome binding site; other site 1121362001401 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 1121362001402 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1121362001403 30S ribosomal protein S11; Validated; Region: PRK05309 1121362001404 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1121362001405 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1121362001406 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1121362001407 RNA binding surface [nucleotide binding]; other site 1121362001408 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1121362001409 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1121362001410 alphaNTD - beta interaction site [polypeptide binding]; other site 1121362001411 alphaNTD homodimer interface [polypeptide binding]; other site 1121362001412 alphaNTD - beta' interaction site [polypeptide binding]; other site 1121362001413 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1121362001414 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1121362001415 PRC-barrel domain; Region: PRC; pfam05239 1121362001416 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 1121362001417 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1121362001418 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1121362001419 dimerization interface 3.5A [polypeptide binding]; other site 1121362001420 active site 1121362001421 Protein of unknown function (DUF690); Region: DUF690; cl04939 1121362001422 Protein of unknown function (DUF690); Region: DUF690; cl04939 1121362001423 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1121362001424 FAD binding domain; Region: FAD_binding_4; pfam01565 1121362001425 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1121362001426 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121362001427 S-adenosylmethionine binding site [chemical binding]; other site 1121362001428 TIGR02611 family protein; Region: TIGR02611 1121362001429 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1121362001430 active site 1121362001431 catalytic residues [active] 1121362001432 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1121362001433 Prophage antirepressor [Transcription]; Region: COG3617 1121362001434 BRO family, N-terminal domain; Region: Bro-N; smart01040 1121362001435 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 1121362001436 polymerase nucleotide-binding site; other site 1121362001437 DNA-binding residues [nucleotide binding]; DNA binding site 1121362001438 nucleotide binding site [chemical binding]; other site 1121362001439 primase nucleotide-binding site [nucleotide binding]; other site 1121362001440 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1121362001441 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1121362001442 catalytic residues [active] 1121362001443 catalytic nucleophile [active] 1121362001444 Recombinase; Region: Recombinase; pfam07508 1121362001445 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1121362001446 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1121362001447 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1121362001448 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1121362001449 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1121362001450 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1121362001451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1121362001452 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1121362001453 23S rRNA interface [nucleotide binding]; other site 1121362001454 L3 interface [polypeptide binding]; other site 1121362001455 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1121362001456 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1121362001457 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1121362001458 active site 1121362001459 substrate binding site [chemical binding]; other site 1121362001460 metal binding site [ion binding]; metal-binding site 1121362001461 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1121362001462 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1121362001463 glutaminase active site [active] 1121362001464 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1121362001465 dimer interface [polypeptide binding]; other site 1121362001466 active site 1121362001467 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1121362001468 dimer interface [polypeptide binding]; other site 1121362001469 active site 1121362001470 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1121362001471 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121362001472 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121362001473 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1121362001474 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1121362001475 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1121362001476 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1121362001477 substrate binding pocket [chemical binding]; other site 1121362001478 dimerization interface [polypeptide binding]; other site 1121362001479 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1121362001480 Cytochrome P450; Region: p450; cl12078 1121362001481 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1121362001482 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 1121362001483 active site 1121362001484 dimer interface [polypeptide binding]; other site 1121362001485 metal binding site [ion binding]; metal-binding site 1121362001486 alanine racemase; Reviewed; Region: alr; PRK00053 1121362001487 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1121362001488 active site 1121362001489 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1121362001490 dimer interface [polypeptide binding]; other site 1121362001491 substrate binding site [chemical binding]; other site 1121362001492 catalytic residues [active] 1121362001493 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1121362001494 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1121362001495 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1121362001496 L-aspartate oxidase; Provisional; Region: PRK06175 1121362001497 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 1121362001498 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1121362001499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121362001500 S-adenosylmethionine binding site [chemical binding]; other site 1121362001501 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1121362001502 Glycoprotease family; Region: Peptidase_M22; pfam00814 1121362001503 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1121362001504 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121362001505 Coenzyme A binding pocket [chemical binding]; other site 1121362001506 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1121362001507 UGMP family protein; Validated; Region: PRK09604 1121362001508 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1121362001509 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1121362001510 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1121362001511 oligomerisation interface [polypeptide binding]; other site 1121362001512 mobile loop; other site 1121362001513 roof hairpin; other site 1121362001514 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1121362001515 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1121362001516 ring oligomerisation interface [polypeptide binding]; other site 1121362001517 ATP/Mg binding site [chemical binding]; other site 1121362001518 stacking interactions; other site 1121362001519 hinge regions; other site 1121362001520 Transcription factor WhiB; Region: Whib; pfam02467 1121362001521 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1121362001522 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121362001523 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121362001524 DNA binding residues [nucleotide binding] 1121362001525 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1121362001526 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1121362001527 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1121362001528 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1121362001529 active site 1121362001530 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1121362001531 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1121362001532 phosphate binding site [ion binding]; other site 1121362001533 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121362001534 PAS domain; Region: PAS_9; pfam13426 1121362001535 putative active site [active] 1121362001536 heme pocket [chemical binding]; other site 1121362001537 GMP synthase; Reviewed; Region: guaA; PRK00074 1121362001538 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1121362001539 AMP/PPi binding site [chemical binding]; other site 1121362001540 candidate oxyanion hole; other site 1121362001541 catalytic triad [active] 1121362001542 potential glutamine specificity residues [chemical binding]; other site 1121362001543 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1121362001544 ATP Binding subdomain [chemical binding]; other site 1121362001545 Ligand Binding sites [chemical binding]; other site 1121362001546 Dimerization subdomain; other site 1121362001547 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 1121362001548 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1121362001549 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 1121362001550 Mg2+ binding site [ion binding]; other site 1121362001551 G-X-G motif; other site 1121362001552 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1121362001553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121362001554 active site 1121362001555 phosphorylation site [posttranslational modification] 1121362001556 intermolecular recognition site; other site 1121362001557 dimerization interface [polypeptide binding]; other site 1121362001558 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1121362001559 dimerization interface [polypeptide binding]; other site 1121362001560 DNA binding residues [nucleotide binding] 1121362001561 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1121362001562 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121362001563 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1121362001564 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 1121362001565 putative dimer interface [polypeptide binding]; other site 1121362001566 putative [2Fe-2S] cluster binding site [ion binding]; other site 1121362001567 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1121362001568 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1121362001569 DNA binding residues [nucleotide binding] 1121362001570 dimer interface [polypeptide binding]; other site 1121362001571 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1121362001572 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1121362001573 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1121362001574 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1121362001575 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1121362001576 active site 1121362001577 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1121362001578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121362001579 dimer interface [polypeptide binding]; other site 1121362001580 conserved gate region; other site 1121362001581 ABC-ATPase subunit interface; other site 1121362001582 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1121362001583 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1121362001584 Walker A/P-loop; other site 1121362001585 ATP binding site [chemical binding]; other site 1121362001586 Q-loop/lid; other site 1121362001587 ABC transporter signature motif; other site 1121362001588 Walker B; other site 1121362001589 D-loop; other site 1121362001590 H-loop/switch region; other site 1121362001591 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1121362001592 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1121362001593 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1121362001594 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1121362001595 Predicted membrane protein [Function unknown]; Region: COG3428 1121362001596 Bacterial PH domain; Region: DUF304; pfam03703 1121362001597 Bacterial PH domain; Region: DUF304; cl01348 1121362001598 Bacterial PH domain; Region: DUF304; pfam03703 1121362001599 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1121362001600 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1121362001601 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1121362001602 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1121362001603 homodimer interface [polypeptide binding]; other site 1121362001604 NADP binding site [chemical binding]; other site 1121362001605 substrate binding site [chemical binding]; other site 1121362001606 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1121362001607 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1121362001608 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1121362001609 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1121362001610 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1121362001611 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05613 1121362001612 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1121362001613 homodimer interface [polypeptide binding]; other site 1121362001614 substrate-cofactor binding pocket; other site 1121362001615 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121362001616 catalytic residue [active] 1121362001617 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1121362001618 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1121362001619 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1121362001620 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1121362001621 FAD binding pocket [chemical binding]; other site 1121362001622 FAD binding motif [chemical binding]; other site 1121362001623 phosphate binding motif [ion binding]; other site 1121362001624 NAD binding pocket [chemical binding]; other site 1121362001625 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1121362001626 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1121362001627 Walker A/P-loop; other site 1121362001628 ATP binding site [chemical binding]; other site 1121362001629 Q-loop/lid; other site 1121362001630 ABC transporter signature motif; other site 1121362001631 Walker B; other site 1121362001632 D-loop; other site 1121362001633 H-loop/switch region; other site 1121362001634 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1121362001635 ABC-ATPase subunit interface; other site 1121362001636 dimer interface [polypeptide binding]; other site 1121362001637 putative PBP binding regions; other site 1121362001638 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1121362001639 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1121362001640 ABC-ATPase subunit interface; other site 1121362001641 dimer interface [polypeptide binding]; other site 1121362001642 putative PBP binding regions; other site 1121362001643 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1121362001644 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1121362001645 siderophore binding site; other site 1121362001646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362001647 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121362001648 putative substrate translocation pore; other site 1121362001649 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1121362001650 putative catalytic site [active] 1121362001651 putative metal binding site [ion binding]; other site 1121362001652 putative phosphate binding site [ion binding]; other site 1121362001653 Predicted membrane protein [Function unknown]; Region: COG2860 1121362001654 UPF0126 domain; Region: UPF0126; pfam03458 1121362001655 UPF0126 domain; Region: UPF0126; pfam03458 1121362001656 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1121362001657 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1121362001658 active site 1121362001659 HIGH motif; other site 1121362001660 dimer interface [polypeptide binding]; other site 1121362001661 KMSKS motif; other site 1121362001662 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1121362001663 RDD family; Region: RDD; pfam06271 1121362001664 adenosine deaminase; Provisional; Region: PRK09358 1121362001665 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1121362001666 active site 1121362001667 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1121362001668 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1121362001669 NlpC/P60 family; Region: NLPC_P60; pfam00877 1121362001670 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121362001671 active site 1121362001672 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1121362001673 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121362001674 non-specific DNA binding site [nucleotide binding]; other site 1121362001675 salt bridge; other site 1121362001676 sequence-specific DNA binding site [nucleotide binding]; other site 1121362001677 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1121362001678 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1121362001679 metal binding site [ion binding]; metal-binding site 1121362001680 putative dimer interface [polypeptide binding]; other site 1121362001681 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1121362001682 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1121362001683 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121362001684 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1121362001685 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1121362001686 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121362001687 sequence-specific DNA binding site [nucleotide binding]; other site 1121362001688 salt bridge; other site 1121362001689 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1121362001690 Domain of unknown function (DUF955); Region: DUF955; cl01076 1121362001691 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1121362001692 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1121362001693 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1121362001694 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1121362001695 tetramer interface [polypeptide binding]; other site 1121362001696 active site 1121362001697 Mg2+/Mn2+ binding site [ion binding]; other site 1121362001698 citrate synthase; Provisional; Region: PRK14033 1121362001699 Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111 1121362001700 dimer interface [polypeptide binding]; other site 1121362001701 active site 1121362001702 citrylCoA binding site [chemical binding]; other site 1121362001703 oxalacetate/citrate binding site [chemical binding]; other site 1121362001704 coenzyme A binding site [chemical binding]; other site 1121362001705 catalytic triad [active] 1121362001706 pyruvate carboxylase; Reviewed; Region: PRK12999 1121362001707 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1121362001708 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1121362001709 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1121362001710 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1121362001711 active site 1121362001712 catalytic residues [active] 1121362001713 metal binding site [ion binding]; metal-binding site 1121362001714 homodimer binding site [polypeptide binding]; other site 1121362001715 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1121362001716 carboxyltransferase (CT) interaction site; other site 1121362001717 biotinylation site [posttranslational modification]; other site 1121362001718 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 1121362001719 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1121362001720 active site 1121362001721 catalytic residues [active] 1121362001722 metal binding site [ion binding]; metal-binding site 1121362001723 potential frameshift: common BLAST hit: gi|226364548|ref|YP_002782330.1| CaiB/BaiF family protein 1121362001724 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1121362001725 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1121362001726 Bacterial transcriptional regulator; Region: IclR; pfam01614 1121362001727 succinic semialdehyde dehydrogenase; Region: PLN02278 1121362001728 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1121362001729 tetramerization interface [polypeptide binding]; other site 1121362001730 NAD(P) binding site [chemical binding]; other site 1121362001731 catalytic residues [active] 1121362001732 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1121362001733 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1121362001734 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 1121362001735 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 1121362001736 tetramer interface [polypeptide binding]; other site 1121362001737 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 1121362001738 tetramer interface [polypeptide binding]; other site 1121362001739 active site 1121362001740 metal binding site [ion binding]; metal-binding site 1121362001741 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 1121362001742 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1121362001743 NAD binding site [chemical binding]; other site 1121362001744 catalytic residues [active] 1121362001745 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1121362001746 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121362001747 DNA-binding site [nucleotide binding]; DNA binding site 1121362001748 FCD domain; Region: FCD; pfam07729 1121362001749 hypothetical protein; Provisional; Region: PRK12764 1121362001750 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1121362001751 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 1121362001752 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362001753 metabolite-proton symporter; Region: 2A0106; TIGR00883 1121362001754 putative substrate translocation pore; other site 1121362001755 phenol 2-monooxygenase; Provisional; Region: PRK08294 1121362001756 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121362001757 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1121362001758 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979 1121362001759 dimer interface [polypeptide binding]; other site 1121362001760 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1121362001761 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1121362001762 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1121362001763 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121362001764 non-specific DNA binding site [nucleotide binding]; other site 1121362001765 salt bridge; other site 1121362001766 sequence-specific DNA binding site [nucleotide binding]; other site 1121362001767 Cupin domain; Region: Cupin_2; pfam07883 1121362001768 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1121362001769 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1121362001770 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1121362001771 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1121362001772 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1121362001773 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1121362001774 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1121362001775 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1121362001776 carboxyltransferase (CT) interaction site; other site 1121362001777 biotinylation site [posttranslational modification]; other site 1121362001778 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1121362001779 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1121362001780 active site residue [active] 1121362001781 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1121362001782 active site residue [active] 1121362001783 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1121362001784 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1121362001785 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1121362001786 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1121362001787 Maf-like protein; Region: Maf; pfam02545 1121362001788 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1121362001789 active site 1121362001790 dimer interface [polypeptide binding]; other site 1121362001791 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1121362001792 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1121362001793 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1121362001794 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1121362001795 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1121362001796 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1121362001797 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1121362001798 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 1121362001799 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1121362001800 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1121362001801 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1121362001802 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1121362001803 ATP-grasp domain; Region: ATP-grasp; pfam02222 1121362001804 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121362001805 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1121362001806 NAD(P) binding site [chemical binding]; other site 1121362001807 active site 1121362001808 AIR carboxylase; Region: AIRC; pfam00731 1121362001809 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1121362001810 putative active site [active] 1121362001811 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1121362001812 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1121362001813 RibD C-terminal domain; Region: RibD_C; cl17279 1121362001814 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1121362001815 MarR family; Region: MarR; pfam01047 1121362001816 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121362001817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121362001818 dimer interface [polypeptide binding]; other site 1121362001819 conserved gate region; other site 1121362001820 putative PBP binding loops; other site 1121362001821 ABC-ATPase subunit interface; other site 1121362001822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121362001823 dimer interface [polypeptide binding]; other site 1121362001824 conserved gate region; other site 1121362001825 putative PBP binding loops; other site 1121362001826 ABC-ATPase subunit interface; other site 1121362001827 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121362001828 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121362001829 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1121362001830 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1121362001831 Walker A/P-loop; other site 1121362001832 ATP binding site [chemical binding]; other site 1121362001833 Q-loop/lid; other site 1121362001834 ABC transporter signature motif; other site 1121362001835 Walker B; other site 1121362001836 D-loop; other site 1121362001837 H-loop/switch region; other site 1121362001838 TOBE domain; Region: TOBE_2; pfam08402 1121362001839 TIGR03089 family protein; Region: TIGR03089 1121362001840 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1121362001841 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1121362001842 active site 1121362001843 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1121362001844 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1121362001845 substrate binding pocket [chemical binding]; other site 1121362001846 substrate-Mg2+ binding site; other site 1121362001847 aspartate-rich region 1; other site 1121362001848 aspartate-rich region 2; other site 1121362001849 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1121362001850 active site lid residues [active] 1121362001851 substrate binding pocket [chemical binding]; other site 1121362001852 catalytic residues [active] 1121362001853 substrate-Mg2+ binding site; other site 1121362001854 aspartate-rich region 1; other site 1121362001855 aspartate-rich region 2; other site 1121362001856 phytoene desaturase; Region: crtI_fam; TIGR02734 1121362001857 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1121362001858 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1121362001859 prenyltransferase; Reviewed; Region: ubiA; PRK13105 1121362001860 UbiA prenyltransferase family; Region: UbiA; pfam01040 1121362001861 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121362001862 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121362001863 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1121362001864 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1121362001865 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1121362001866 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1121362001867 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1121362001868 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1121362001869 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1121362001870 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1121362001871 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1121362001872 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121362001873 ATP binding site [chemical binding]; other site 1121362001874 putative Mg++ binding site [ion binding]; other site 1121362001875 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1121362001876 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1121362001877 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1121362001878 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1121362001879 active site 1121362001880 substrate binding site [chemical binding]; other site 1121362001881 catalytic site [active] 1121362001882 Transposase; Region: HTH_Tnp_1; cl17663 1121362001883 putative transposase OrfB; Reviewed; Region: PHA02517 1121362001884 HTH-like domain; Region: HTH_21; pfam13276 1121362001885 Integrase core domain; Region: rve; pfam00665 1121362001886 Integrase core domain; Region: rve_3; pfam13683 1121362001887 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1121362001888 Amidase; Region: Amidase; cl11426 1121362001889 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: COG2248 1121362001890 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1121362001891 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1121362001892 transmembrane helices; other site 1121362001893 TspO/MBR family; Region: TspO_MBR; pfam03073 1121362001894 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1121362001895 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1121362001896 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1121362001897 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1121362001898 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1121362001899 NADP binding site [chemical binding]; other site 1121362001900 active site 1121362001901 putative substrate binding site [chemical binding]; other site 1121362001902 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1121362001903 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1121362001904 Probable Catalytic site; other site 1121362001905 metal-binding site 1121362001906 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1121362001907 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1121362001908 active site 1121362001909 Substrate binding site; other site 1121362001910 Mg++ binding site; other site 1121362001911 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1121362001912 putative trimer interface [polypeptide binding]; other site 1121362001913 putative CoA binding site [chemical binding]; other site 1121362001914 Transcription factor WhiB; Region: Whib; pfam02467 1121362001915 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1121362001916 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1121362001917 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1121362001918 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1121362001919 active site 1121362001920 substrate binding site [chemical binding]; other site 1121362001921 metal binding site [ion binding]; metal-binding site 1121362001922 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1121362001923 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1121362001924 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1121362001925 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1121362001926 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 1121362001927 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1121362001928 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1121362001929 homotetramer interface [polypeptide binding]; other site 1121362001930 ligand binding site [chemical binding]; other site 1121362001931 catalytic site [active] 1121362001932 NAD binding site [chemical binding]; other site 1121362001933 thymidylate kinase; Validated; Region: PRK07933 1121362001934 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121362001935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121362001936 active site 1121362001937 phosphorylation site [posttranslational modification] 1121362001938 intermolecular recognition site; other site 1121362001939 dimerization interface [polypeptide binding]; other site 1121362001940 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121362001941 DNA binding site [nucleotide binding] 1121362001942 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121362001943 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121362001944 dimerization interface [polypeptide binding]; other site 1121362001945 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121362001946 dimer interface [polypeptide binding]; other site 1121362001947 phosphorylation site [posttranslational modification] 1121362001948 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121362001949 ATP binding site [chemical binding]; other site 1121362001950 Mg2+ binding site [ion binding]; other site 1121362001951 G-X-G motif; other site 1121362001952 lipoprotein LpqB; Provisional; Region: PRK13616 1121362001953 Sporulation and spore germination; Region: Germane; pfam10646 1121362001954 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1121362001955 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121362001956 active site 1121362001957 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1121362001958 30S subunit binding site; other site 1121362001959 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1121362001960 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1121362001961 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121362001962 nucleotide binding region [chemical binding]; other site 1121362001963 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 1121362001964 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1121362001965 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1121362001966 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1121362001967 FAD binding pocket [chemical binding]; other site 1121362001968 FAD binding motif [chemical binding]; other site 1121362001969 phosphate binding motif [ion binding]; other site 1121362001970 beta-alpha-beta structure motif; other site 1121362001971 NAD binding pocket [chemical binding]; other site 1121362001972 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1121362001973 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1121362001974 catalytic loop [active] 1121362001975 iron binding site [ion binding]; other site 1121362001976 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1121362001977 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1121362001978 putative di-iron ligands [ion binding]; other site 1121362001979 Lipase maturation factor; Region: LMF1; pfam06762 1121362001980 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1121362001981 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 1121362001982 putative ion selectivity filter; other site 1121362001983 putative pore gating glutamate residue; other site 1121362001984 Predicted GTPases [General function prediction only]; Region: COG1162 1121362001985 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1121362001986 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1121362001987 GTP/Mg2+ binding site [chemical binding]; other site 1121362001988 G4 box; other site 1121362001989 G5 box; other site 1121362001990 G1 box; other site 1121362001991 Switch I region; other site 1121362001992 G2 box; other site 1121362001993 G3 box; other site 1121362001994 Switch II region; other site 1121362001995 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1121362001996 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1121362001997 hinge; other site 1121362001998 active site 1121362001999 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1121362002000 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1121362002001 putative deacylase active site [active] 1121362002002 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1121362002003 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121362002004 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121362002005 DNA binding residues [nucleotide binding] 1121362002006 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 1121362002007 Transcription factor WhiB; Region: Whib; pfam02467 1121362002008 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1121362002009 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1121362002010 ATP binding site [chemical binding]; other site 1121362002011 putative Mg++ binding site [ion binding]; other site 1121362002012 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121362002013 nucleotide binding region [chemical binding]; other site 1121362002014 ATP-binding site [chemical binding]; other site 1121362002015 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1121362002016 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1121362002017 TIGR02569 family protein; Region: TIGR02569_actnb 1121362002018 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1121362002019 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1121362002020 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1121362002021 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 1121362002022 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1121362002023 Ion channel; Region: Ion_trans_2; pfam07885 1121362002024 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1121362002025 TrkA-N domain; Region: TrkA_N; pfam02254 1121362002026 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1121362002027 putative NADH binding site [chemical binding]; other site 1121362002028 putative active site [active] 1121362002029 nudix motif; other site 1121362002030 putative metal binding site [ion binding]; other site 1121362002031 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1121362002032 Part of AAA domain; Region: AAA_19; pfam13245 1121362002033 Family description; Region: UvrD_C_2; pfam13538 1121362002034 HRDC domain; Region: HRDC; pfam00570 1121362002035 Protein of unknown function DUF45; Region: DUF45; pfam01863 1121362002036 putative hydrolase; Region: TIGR03624 1121362002037 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1121362002038 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1121362002039 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1121362002040 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1121362002041 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 1121362002042 hypothetical protein; Validated; Region: PRK00068 1121362002043 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1121362002044 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1121362002045 active site 1121362002046 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1121362002047 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1121362002048 active site 1121362002049 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1121362002050 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1121362002051 RF-1 domain; Region: RF-1; pfam00472 1121362002052 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1121362002053 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362002054 Walker A/P-loop; other site 1121362002055 ATP binding site [chemical binding]; other site 1121362002056 Q-loop/lid; other site 1121362002057 ABC transporter signature motif; other site 1121362002058 Walker B; other site 1121362002059 D-loop; other site 1121362002060 H-loop/switch region; other site 1121362002061 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1121362002062 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1121362002063 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1121362002064 SmpB-tmRNA interface; other site 1121362002065 Protein of unknown function, DUF488; Region: DUF488; cl01246 1121362002066 short chain dehydrogenase; Provisional; Region: PRK08219 1121362002067 classical (c) SDRs; Region: SDR_c; cd05233 1121362002068 NAD(P) binding site [chemical binding]; other site 1121362002069 active site 1121362002070 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1121362002071 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1121362002072 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1121362002073 intersubunit interface [polypeptide binding]; other site 1121362002074 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1121362002075 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1121362002076 ABC-ATPase subunit interface; other site 1121362002077 dimer interface [polypeptide binding]; other site 1121362002078 putative PBP binding regions; other site 1121362002079 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1121362002080 ABC-ATPase subunit interface; other site 1121362002081 dimer interface [polypeptide binding]; other site 1121362002082 putative PBP binding regions; other site 1121362002083 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1121362002084 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1121362002085 Walker A/P-loop; other site 1121362002086 ATP binding site [chemical binding]; other site 1121362002087 Q-loop/lid; other site 1121362002088 ABC transporter signature motif; other site 1121362002089 Walker B; other site 1121362002090 D-loop; other site 1121362002091 H-loop/switch region; other site 1121362002092 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1121362002093 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 1121362002094 aminotransferase; Validated; Region: PRK07777 1121362002095 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121362002096 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121362002097 homodimer interface [polypeptide binding]; other site 1121362002098 catalytic residue [active] 1121362002099 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 1121362002100 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1121362002101 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1121362002102 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121362002103 ATP binding site [chemical binding]; other site 1121362002104 putative Mg++ binding site [ion binding]; other site 1121362002105 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121362002106 nucleotide binding region [chemical binding]; other site 1121362002107 ATP-binding site [chemical binding]; other site 1121362002108 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1121362002109 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1121362002110 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362002111 Walker A/P-loop; other site 1121362002112 ATP binding site [chemical binding]; other site 1121362002113 Q-loop/lid; other site 1121362002114 ABC transporter signature motif; other site 1121362002115 Walker B; other site 1121362002116 D-loop; other site 1121362002117 H-loop/switch region; other site 1121362002118 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121362002119 sequence-specific DNA binding site [nucleotide binding]; other site 1121362002120 salt bridge; other site 1121362002121 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1121362002122 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1121362002123 Protein of unknown function (DUF3235); Region: DUF3235; pfam11574 1121362002124 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1121362002125 DNA-binding site [nucleotide binding]; DNA binding site 1121362002126 RNA-binding motif; other site 1121362002127 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 1121362002128 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 1121362002129 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1121362002130 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1121362002131 substrate-cofactor binding pocket; other site 1121362002132 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121362002133 catalytic residue [active] 1121362002134 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1121362002135 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1121362002136 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1121362002137 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1121362002138 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1121362002139 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1121362002140 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121362002141 catalytic residue [active] 1121362002142 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1121362002143 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1121362002144 dimer interface [polypeptide binding]; other site 1121362002145 active site 1121362002146 citrylCoA binding site [chemical binding]; other site 1121362002147 NADH binding [chemical binding]; other site 1121362002148 cationic pore residues; other site 1121362002149 oxalacetate/citrate binding site [chemical binding]; other site 1121362002150 coenzyme A binding site [chemical binding]; other site 1121362002151 catalytic triad [active] 1121362002152 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1121362002153 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1121362002154 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1121362002155 active site 1121362002156 catalytic tetrad [active] 1121362002157 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1121362002158 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1121362002159 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1121362002160 Na binding site [ion binding]; other site 1121362002161 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1121362002162 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1121362002163 catalytic site [active] 1121362002164 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1121362002165 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1121362002166 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1121362002167 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1121362002168 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1121362002169 folate binding site [chemical binding]; other site 1121362002170 NADP+ binding site [chemical binding]; other site 1121362002171 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1121362002172 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1121362002173 dimerization interface [polypeptide binding]; other site 1121362002174 active site 1121362002175 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1121362002176 active site 1121362002177 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121362002178 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1121362002179 ATP binding site [chemical binding]; other site 1121362002180 putative Mg++ binding site [ion binding]; other site 1121362002181 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121362002182 nucleotide binding region [chemical binding]; other site 1121362002183 ATP-binding site [chemical binding]; other site 1121362002184 DEAD/H associated; Region: DEAD_assoc; pfam08494 1121362002185 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1121362002186 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1121362002187 putative DNA binding site [nucleotide binding]; other site 1121362002188 catalytic residue [active] 1121362002189 putative H2TH interface [polypeptide binding]; other site 1121362002190 putative catalytic residues [active] 1121362002191 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1121362002192 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1121362002193 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1121362002194 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1121362002195 Vacuolar protein sorting 55; Region: Vps55; pfam04133 1121362002196 hypothetical protein; Provisional; Region: PRK11770 1121362002197 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1121362002198 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1121362002199 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1121362002200 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1121362002201 active site 1121362002202 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1121362002203 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1121362002204 active site 1121362002205 dimer interface [polypeptide binding]; other site 1121362002206 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1121362002207 dimer interface [polypeptide binding]; other site 1121362002208 active site 1121362002209 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1121362002210 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1121362002211 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1121362002212 tetramerization interface [polypeptide binding]; other site 1121362002213 NAD(P) binding site [chemical binding]; other site 1121362002214 catalytic residues [active] 1121362002215 hypothetical protein; Provisional; Region: PRK07857 1121362002216 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1121362002217 Part of AAA domain; Region: AAA_19; pfam13245 1121362002218 Family description; Region: UvrD_C_2; pfam13538 1121362002219 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1121362002220 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1121362002221 Walker A/P-loop; other site 1121362002222 ATP binding site [chemical binding]; other site 1121362002223 Q-loop/lid; other site 1121362002224 ABC transporter signature motif; other site 1121362002225 Walker B; other site 1121362002226 D-loop; other site 1121362002227 H-loop/switch region; other site 1121362002228 Predicted transcriptional regulators [Transcription]; Region: COG1695 1121362002229 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1121362002230 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1121362002231 Peptidase family M23; Region: Peptidase_M23; pfam01551 1121362002232 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1121362002233 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1121362002234 active site 1121362002235 substrate binding site [chemical binding]; other site 1121362002236 cosubstrate binding site; other site 1121362002237 catalytic site [active] 1121362002238 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1121362002239 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1121362002240 purine monophosphate binding site [chemical binding]; other site 1121362002241 dimer interface [polypeptide binding]; other site 1121362002242 putative catalytic residues [active] 1121362002243 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1121362002244 RDD family; Region: RDD; pfam06271 1121362002245 RDD family; Region: RDD; pfam06271 1121362002246 RDD family; Region: RDD; pfam06271 1121362002247 RDD family; Region: RDD; cl00746 1121362002248 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1121362002249 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121362002250 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121362002251 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 1121362002252 30S ribosomal protein S18; Provisional; Region: PRK13401 1121362002253 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1121362002254 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1121362002255 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1121362002256 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1121362002257 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1121362002258 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121362002259 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121362002260 active site 1121362002261 phosphorylation site [posttranslational modification] 1121362002262 intermolecular recognition site; other site 1121362002263 dimerization interface [polypeptide binding]; other site 1121362002264 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121362002265 DNA binding site [nucleotide binding] 1121362002266 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1121362002267 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121362002268 dimerization interface [polypeptide binding]; other site 1121362002269 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121362002270 dimer interface [polypeptide binding]; other site 1121362002271 phosphorylation site [posttranslational modification] 1121362002272 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121362002273 ATP binding site [chemical binding]; other site 1121362002274 Mg2+ binding site [ion binding]; other site 1121362002275 G-X-G motif; other site 1121362002276 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1121362002277 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1121362002278 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1121362002279 protein binding site [polypeptide binding]; other site 1121362002280 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1121362002281 MPT binding site; other site 1121362002282 trimer interface [polypeptide binding]; other site 1121362002283 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1121362002284 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1121362002285 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1121362002286 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1121362002287 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1121362002288 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 1121362002289 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1121362002290 active site 1121362002291 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1121362002292 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1121362002293 dimer interface [polypeptide binding]; other site 1121362002294 putative functional site; other site 1121362002295 putative MPT binding site; other site 1121362002296 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1121362002297 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1121362002298 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1121362002299 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1121362002300 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1121362002301 DNA binding site [nucleotide binding] 1121362002302 active site 1121362002303 Predicted membrane protein [Function unknown]; Region: COG2259 1121362002304 Predicted integral membrane protein [Function unknown]; Region: COG5660 1121362002305 Putative zinc-finger; Region: zf-HC2; pfam13490 1121362002306 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 1121362002307 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1121362002308 Predicted methyltransferases [General function prediction only]; Region: COG0313 1121362002309 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1121362002310 putative SAM binding site [chemical binding]; other site 1121362002311 putative homodimer interface [polypeptide binding]; other site 1121362002312 BCCT family transporter; Region: BCCT; pfam02028 1121362002313 BCCT family transporter; Region: BCCT; pfam02028 1121362002314 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1121362002315 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1121362002316 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1121362002317 active site 1121362002318 HIGH motif; other site 1121362002319 KMSKS motif; other site 1121362002320 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1121362002321 tRNA binding surface [nucleotide binding]; other site 1121362002322 anticodon binding site; other site 1121362002323 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1121362002324 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362002325 putative substrate translocation pore; other site 1121362002326 potential frameshift: common BLAST hit: gi|62389784|ref|YP_225186.1| ATP-dependent DNA helicase 1121362002327 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1121362002328 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121362002329 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1121362002330 Coenzyme A binding pocket [chemical binding]; other site 1121362002331 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1121362002332 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1121362002333 active site 1121362002334 substrate binding site [chemical binding]; other site 1121362002335 ATP binding site [chemical binding]; other site 1121362002336 Phosphotransferase enzyme family; Region: APH; pfam01636 1121362002337 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1121362002338 substrate binding site [chemical binding]; other site 1121362002339 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1121362002340 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1121362002341 active site residue [active] 1121362002342 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1121362002343 active site residue [active] 1121362002344 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1121362002345 active site 1121362002346 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1121362002347 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1121362002348 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1121362002349 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1121362002350 G5 domain; Region: G5; pfam07501 1121362002351 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1121362002352 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1121362002353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121362002354 S-adenosylmethionine binding site [chemical binding]; other site 1121362002355 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1121362002356 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1121362002357 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1121362002358 ABC transporter; Region: ABC_tran_2; pfam12848 1121362002359 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1121362002360 Predicted membrane protein [Function unknown]; Region: COG4425 1121362002361 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1121362002362 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1121362002363 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1121362002364 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1121362002365 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1121362002366 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1121362002367 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1121362002368 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1121362002369 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1121362002370 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1121362002371 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1121362002372 substrate binding site [chemical binding]; other site 1121362002373 oxyanion hole (OAH) forming residues; other site 1121362002374 trimer interface [polypeptide binding]; other site 1121362002375 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1121362002376 Predicted membrane protein [General function prediction only]; Region: COG4194 1121362002377 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1121362002378 Putative esterase; Region: Esterase; pfam00756 1121362002379 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1121362002380 malate synthase G; Provisional; Region: PRK02999 1121362002381 active site 1121362002382 isocitrate lyase; Provisional; Region: PRK15063 1121362002383 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1121362002384 tetramer interface [polypeptide binding]; other site 1121362002385 active site 1121362002386 Mg2+/Mn2+ binding site [ion binding]; other site 1121362002387 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1121362002388 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121362002389 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121362002390 MMPL family; Region: MMPL; pfam03176 1121362002391 MMPL family; Region: MMPL; pfam03176 1121362002392 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1121362002393 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1121362002394 hypothetical protein; Provisional; Region: PRK05463 1121362002395 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1121362002396 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121362002397 DNA-binding site [nucleotide binding]; DNA binding site 1121362002398 FCD domain; Region: FCD; pfam07729 1121362002399 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1121362002400 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1121362002401 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1121362002402 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1121362002403 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 1121362002404 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1121362002405 carboxyltransferase (CT) interaction site; other site 1121362002406 biotinylation site [posttranslational modification]; other site 1121362002407 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1121362002408 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1121362002409 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 1121362002410 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1121362002411 putative active site [active] 1121362002412 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121362002413 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1121362002414 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121362002415 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1121362002416 NAD(P) binding site [chemical binding]; other site 1121362002417 active site 1121362002418 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 1121362002419 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1121362002420 G1 box; other site 1121362002421 putative GEF interaction site [polypeptide binding]; other site 1121362002422 GTP/Mg2+ binding site [chemical binding]; other site 1121362002423 Switch I region; other site 1121362002424 G2 box; other site 1121362002425 G3 box; other site 1121362002426 Switch II region; other site 1121362002427 G4 box; other site 1121362002428 G5 box; other site 1121362002429 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1121362002430 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 1121362002431 short chain dehydrogenase; Provisional; Region: PRK06197 1121362002432 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121362002433 NAD(P) binding site [chemical binding]; other site 1121362002434 active site 1121362002435 Predicted flavoprotein [General function prediction only]; Region: COG0431 1121362002436 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1121362002437 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1121362002438 putative active site [active] 1121362002439 catalytic residue [active] 1121362002440 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1121362002441 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1121362002442 FMN binding site [chemical binding]; other site 1121362002443 substrate binding site [chemical binding]; other site 1121362002444 putative catalytic residue [active] 1121362002445 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 1121362002446 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1121362002447 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1121362002448 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1121362002449 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1121362002450 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 1121362002451 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1121362002452 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 1121362002453 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1121362002454 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1121362002455 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 1121362002456 Cupin domain; Region: Cupin_2; pfam07883 1121362002457 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1121362002458 Bacterial transcriptional regulator; Region: IclR; pfam01614 1121362002459 benzoate transport; Region: 2A0115; TIGR00895 1121362002460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362002461 putative substrate translocation pore; other site 1121362002462 salicylate hydroxylase; Provisional; Region: PRK08163 1121362002463 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1121362002464 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1121362002465 putative active site [active] 1121362002466 catalytic residue [active] 1121362002467 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1121362002468 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 1121362002469 5S rRNA interface [nucleotide binding]; other site 1121362002470 CTC domain interface [polypeptide binding]; other site 1121362002471 L16 interface [polypeptide binding]; other site 1121362002472 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1121362002473 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1121362002474 active site 1 [active] 1121362002475 dimer interface [polypeptide binding]; other site 1121362002476 hexamer interface [polypeptide binding]; other site 1121362002477 active site 2 [active] 1121362002478 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1121362002479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362002480 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121362002481 putative substrate translocation pore; other site 1121362002482 EcsC protein family; Region: EcsC; pfam12787 1121362002483 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 1121362002484 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1121362002485 active site 1121362002486 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1121362002487 classical (c) SDRs; Region: SDR_c; cd05233 1121362002488 NAD(P) binding site [chemical binding]; other site 1121362002489 active site 1121362002490 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1121362002491 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1121362002492 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121362002493 active site 1121362002494 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1121362002495 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1121362002496 Substrate binding site; other site 1121362002497 Mg++ binding site; other site 1121362002498 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1121362002499 active site 1121362002500 substrate binding site [chemical binding]; other site 1121362002501 CoA binding site [chemical binding]; other site 1121362002502 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121362002503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362002504 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121362002505 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121362002506 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1121362002507 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1121362002508 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121362002509 ATP binding site [chemical binding]; other site 1121362002510 putative Mg++ binding site [ion binding]; other site 1121362002511 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121362002512 nucleotide binding region [chemical binding]; other site 1121362002513 ATP-binding site [chemical binding]; other site 1121362002514 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1121362002515 OsmC-like protein; Region: OsmC; pfam02566 1121362002516 quinolinate synthetase; Provisional; Region: PRK09375 1121362002517 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1121362002518 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1121362002519 homodimer interface [polypeptide binding]; other site 1121362002520 metal binding site [ion binding]; metal-binding site 1121362002521 Alpha helical Porin B; Region: PorB; pfam11565 1121362002522 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1121362002523 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1121362002524 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1121362002525 enolase; Provisional; Region: eno; PRK00077 1121362002526 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1121362002527 dimer interface [polypeptide binding]; other site 1121362002528 metal binding site [ion binding]; metal-binding site 1121362002529 substrate binding pocket [chemical binding]; other site 1121362002530 Septum formation initiator; Region: DivIC; pfam04977 1121362002531 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1121362002532 Uncharacterized conserved protein [Function unknown]; Region: COG1507 1121362002533 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1121362002534 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1121362002535 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1121362002536 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 1121362002537 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1121362002538 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1121362002539 putative NAD(P) binding site [chemical binding]; other site 1121362002540 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 1121362002541 putative active site [active] 1121362002542 Domain of unknown function DUF21; Region: DUF21; pfam01595 1121362002543 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1121362002544 potential frameshift: common BLAST hit: gi|62390082|ref|YP_225484.1| CBS domain-containing protein 1121362002545 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1121362002546 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1121362002547 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1121362002548 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1121362002549 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1121362002550 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 1121362002551 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1121362002552 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1121362002553 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1121362002554 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1121362002555 catalytic residue [active] 1121362002556 putative FPP diphosphate binding site; other site 1121362002557 putative FPP binding hydrophobic cleft; other site 1121362002558 dimer interface [polypeptide binding]; other site 1121362002559 putative IPP diphosphate binding site; other site 1121362002560 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 1121362002561 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121362002562 dimerization interface [polypeptide binding]; other site 1121362002563 putative DNA binding site [nucleotide binding]; other site 1121362002564 pantothenate kinase; Provisional; Region: PRK05439 1121362002565 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1121362002566 ATP-binding site [chemical binding]; other site 1121362002567 CoA-binding site [chemical binding]; other site 1121362002568 Mg2+-binding site [ion binding]; other site 1121362002569 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1121362002570 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1121362002571 dimer interface [polypeptide binding]; other site 1121362002572 active site 1121362002573 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1121362002574 folate binding site [chemical binding]; other site 1121362002575 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121362002576 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121362002577 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 1121362002578 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1121362002579 active site 1121362002580 catalytic site [active] 1121362002581 benzoate transport; Region: 2A0115; TIGR00895 1121362002582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362002583 putative substrate translocation pore; other site 1121362002584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362002585 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1121362002586 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1121362002587 dimerization interface [polypeptide binding]; other site 1121362002588 LGFP repeat; Region: LGFP; pfam08310 1121362002589 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1121362002590 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1121362002591 putative active site [active] 1121362002592 PhoH-like protein; Region: PhoH; pfam02562 1121362002593 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1121362002594 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121362002595 Coenzyme A binding pocket [chemical binding]; other site 1121362002596 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 1121362002597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362002598 putative substrate translocation pore; other site 1121362002599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362002600 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121362002601 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121362002602 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 1121362002603 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1121362002604 Class II fumarases; Region: Fumarase_classII; cd01362 1121362002605 active site 1121362002606 tetramer interface [polypeptide binding]; other site 1121362002607 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1121362002608 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1121362002609 putative active site [active] 1121362002610 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1121362002611 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1121362002612 homotrimer interaction site [polypeptide binding]; other site 1121362002613 putative active site [active] 1121362002614 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1121362002615 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1121362002616 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1121362002617 generic binding surface II; other site 1121362002618 generic binding surface I; other site 1121362002619 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1121362002620 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1121362002621 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1121362002622 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1121362002623 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1121362002624 GTP-binding protein YchF; Reviewed; Region: PRK09601 1121362002625 YchF GTPase; Region: YchF; cd01900 1121362002626 G1 box; other site 1121362002627 GTP/Mg2+ binding site [chemical binding]; other site 1121362002628 Switch I region; other site 1121362002629 G2 box; other site 1121362002630 Switch II region; other site 1121362002631 G3 box; other site 1121362002632 G4 box; other site 1121362002633 G5 box; other site 1121362002634 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1121362002635 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1121362002636 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1121362002637 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121362002638 sequence-specific DNA binding site [nucleotide binding]; other site 1121362002639 salt bridge; other site 1121362002640 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1121362002641 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1121362002642 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1121362002643 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1121362002644 FMN binding site [chemical binding]; other site 1121362002645 active site 1121362002646 substrate binding site [chemical binding]; other site 1121362002647 catalytic residue [active] 1121362002648 Tocopherol cyclase; Region: Tocopherol_cycl; cl14571 1121362002649 Tocopherol cyclase; Region: Tocopherol_cycl; cl14571 1121362002650 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1121362002651 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1121362002652 hypothetical protein; Provisional; Region: PRK14059 1121362002653 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 1121362002654 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1121362002655 metal ion-dependent adhesion site (MIDAS); other site 1121362002656 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 1121362002657 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1121362002658 catalytic core [active] 1121362002659 conserved hypothetical protein; Region: TIGR03843 1121362002660 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1121362002661 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1121362002662 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 1121362002663 putative catalytic site [active] 1121362002664 putative metal binding site [ion binding]; other site 1121362002665 putative phosphate binding site [ion binding]; other site 1121362002666 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 1121362002667 Phosphotransferase enzyme family; Region: APH; pfam01636 1121362002668 putative active site [active] 1121362002669 putative substrate binding site [chemical binding]; other site 1121362002670 ATP binding site [chemical binding]; other site 1121362002671 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1121362002672 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1121362002673 dimer interface [polypeptide binding]; other site 1121362002674 putative radical transfer pathway; other site 1121362002675 diiron center [ion binding]; other site 1121362002676 tyrosyl radical; other site 1121362002677 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1121362002678 hydrophobic ligand binding site; other site 1121362002679 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1121362002680 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 1121362002681 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1121362002682 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1121362002683 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1121362002684 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1121362002685 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1121362002686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362002687 putative substrate translocation pore; other site 1121362002688 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1121362002689 FAD binding domain; Region: FAD_binding_3; pfam01494 1121362002690 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1121362002691 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1121362002692 active site 1121362002693 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1121362002694 active site 1121362002695 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1121362002696 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121362002697 DNA-binding site [nucleotide binding]; DNA binding site 1121362002698 UTRA domain; Region: UTRA; pfam07702 1121362002699 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 1121362002700 gating phenylalanine in ion channel; other site 1121362002701 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1121362002702 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121362002703 NAD(P) binding site [chemical binding]; other site 1121362002704 active site 1121362002705 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1121362002706 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1121362002707 putative NAD(P) binding site [chemical binding]; other site 1121362002708 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1121362002709 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1121362002710 putative NAD(P) binding site [chemical binding]; other site 1121362002711 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1121362002712 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1121362002713 tetramer interface [polypeptide binding]; other site 1121362002714 heme binding pocket [chemical binding]; other site 1121362002715 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1121362002716 FAD binding domain; Region: FAD_binding_4; pfam01565 1121362002717 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1121362002718 Anabaena sensory rhodopsin transducer; Region: ASRT; cl01751 1121362002719 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1121362002720 E-class dimer interface [polypeptide binding]; other site 1121362002721 P-class dimer interface [polypeptide binding]; other site 1121362002722 active site 1121362002723 Cu2+ binding site [ion binding]; other site 1121362002724 Zn2+ binding site [ion binding]; other site 1121362002725 Thymidine kinase [Nucleotide transport and metabolism]; Region: Tdk; COG1435 1121362002726 recA bacterial DNA recombination protein; Region: RecA; cl17211 1121362002727 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 1121362002728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121362002729 S-adenosylmethionine binding site [chemical binding]; other site 1121362002730 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1121362002731 putative ADP-ribose binding site [chemical binding]; other site 1121362002732 putative active site [active] 1121362002733 choline dehydrogenase; Validated; Region: PRK02106 1121362002734 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1121362002735 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1121362002736 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1121362002737 NAD(P) binding site [chemical binding]; other site 1121362002738 catalytic residues [active] 1121362002739 BCCT family transporter; Region: BCCT; cl00569 1121362002740 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121362002741 Coenzyme A binding pocket [chemical binding]; other site 1121362002742 peptide chain release factor 1, archaeal and eukaryotic forms; Region: aRF1/eRF1; TIGR03676 1121362002743 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1121362002744 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1121362002745 putative NAD(P) binding site [chemical binding]; other site 1121362002746 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1121362002747 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1121362002748 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1121362002749 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1121362002750 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1121362002751 molybdopterin cofactor binding site; other site 1121362002752 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 1121362002753 4Fe-4S binding domain; Region: Fer4; cl02805 1121362002754 selenium donor protein; Region: selD; TIGR00476 1121362002755 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1121362002756 dimerization interface [polypeptide binding]; other site 1121362002757 putative ATP binding site [chemical binding]; other site 1121362002758 selenocysteine synthase; Provisional; Region: PRK04311 1121362002759 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 1121362002760 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1121362002761 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121362002762 catalytic residue [active] 1121362002763 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 1121362002764 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1121362002765 G1 box; other site 1121362002766 putative GEF interaction site [polypeptide binding]; other site 1121362002767 GTP/Mg2+ binding site [chemical binding]; other site 1121362002768 Switch I region; other site 1121362002769 G2 box; other site 1121362002770 G3 box; other site 1121362002771 Switch II region; other site 1121362002772 G4 box; other site 1121362002773 G5 box; other site 1121362002774 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1121362002775 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1121362002776 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1121362002777 active site 1121362002778 SUMO-1 interface [polypeptide binding]; other site 1121362002779 BCCT family transporter; Region: BCCT; pfam02028 1121362002780 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1121362002781 Cytochrome P450; Region: p450; cl12078 1121362002782 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1121362002783 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362002784 Walker A/P-loop; other site 1121362002785 ATP binding site [chemical binding]; other site 1121362002786 Q-loop/lid; other site 1121362002787 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362002788 ABC transporter signature motif; other site 1121362002789 Walker B; other site 1121362002790 D-loop; other site 1121362002791 H-loop/switch region; other site 1121362002792 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362002793 Walker A/P-loop; other site 1121362002794 ATP binding site [chemical binding]; other site 1121362002795 Q-loop/lid; other site 1121362002796 ABC transporter; Region: ABC_tran; pfam00005 1121362002797 ABC transporter signature motif; other site 1121362002798 Walker B; other site 1121362002799 D-loop; other site 1121362002800 H-loop/switch region; other site 1121362002801 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1121362002802 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1121362002803 Domain of unknown function DUF21; Region: DUF21; pfam01595 1121362002804 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1121362002805 Transporter associated domain; Region: CorC_HlyC; smart01091 1121362002806 zinc transporter ZupT; Provisional; Region: PRK04201 1121362002807 ZIP Zinc transporter; Region: Zip; pfam02535 1121362002808 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 1121362002809 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1121362002810 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1121362002811 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1121362002812 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424 1121362002813 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 1121362002814 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1121362002815 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1121362002816 Walker A/P-loop; other site 1121362002817 ATP binding site [chemical binding]; other site 1121362002818 Q-loop/lid; other site 1121362002819 ABC transporter signature motif; other site 1121362002820 Walker B; other site 1121362002821 D-loop; other site 1121362002822 H-loop/switch region; other site 1121362002823 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1121362002824 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1121362002825 Walker A/P-loop; other site 1121362002826 ATP binding site [chemical binding]; other site 1121362002827 Q-loop/lid; other site 1121362002828 ABC transporter signature motif; other site 1121362002829 Walker B; other site 1121362002830 D-loop; other site 1121362002831 H-loop/switch region; other site 1121362002832 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1121362002833 hypothetical protein; Provisional; Region: PRK06547 1121362002834 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1121362002835 nudix motif; other site 1121362002836 FOG: CBS domain [General function prediction only]; Region: COG0517 1121362002837 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1121362002838 thiamine pyrophosphate protein; Provisional; Region: PRK08273 1121362002839 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1121362002840 PYR/PP interface [polypeptide binding]; other site 1121362002841 dimer interface [polypeptide binding]; other site 1121362002842 tetramer interface [polypeptide binding]; other site 1121362002843 TPP binding site [chemical binding]; other site 1121362002844 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1121362002845 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1121362002846 TPP-binding site [chemical binding]; other site 1121362002847 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1121362002848 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1121362002849 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1121362002850 iron-sulfur cluster [ion binding]; other site 1121362002851 [2Fe-2S] cluster binding site [ion binding]; other site 1121362002852 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1121362002853 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1121362002854 NAD binding site [chemical binding]; other site 1121362002855 catalytic Zn binding site [ion binding]; other site 1121362002856 structural Zn binding site [ion binding]; other site 1121362002857 Competence-damaged protein; Region: CinA; pfam02464 1121362002858 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1121362002859 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121362002860 NAD(P) binding site [chemical binding]; other site 1121362002861 active site 1121362002862 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1121362002863 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1121362002864 active site 1121362002865 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 1121362002866 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1121362002867 substrate binding site [chemical binding]; other site 1121362002868 ATP binding site [chemical binding]; other site 1121362002869 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1121362002870 active site 1121362002871 nucleotide binding site [chemical binding]; other site 1121362002872 HIGH motif; other site 1121362002873 KMSKS motif; other site 1121362002874 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1121362002875 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 1121362002876 NAD(P) binding site [chemical binding]; other site 1121362002877 catalytic residues [active] 1121362002878 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1121362002879 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1121362002880 putative active site [active] 1121362002881 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1121362002882 classical (c) SDRs; Region: SDR_c; cd05233 1121362002883 NAD(P) binding site [chemical binding]; other site 1121362002884 active site 1121362002885 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1121362002886 substrate binding site [chemical binding]; other site 1121362002887 ATP binding site [chemical binding]; other site 1121362002888 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1121362002889 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1121362002890 active site 1121362002891 HIGH motif; other site 1121362002892 nucleotide binding site [chemical binding]; other site 1121362002893 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1121362002894 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1121362002895 putative ADP-binding pocket [chemical binding]; other site 1121362002896 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1121362002897 dimer interface [polypeptide binding]; other site 1121362002898 active site 1121362002899 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121362002900 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1121362002901 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1121362002902 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1121362002903 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1121362002904 putative active site [active] 1121362002905 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121362002906 motif II; other site 1121362002907 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1121362002908 putative active site [active] 1121362002909 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1121362002910 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1121362002911 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362002912 ABC transporter signature motif; other site 1121362002913 Walker B; other site 1121362002914 D-loop; other site 1121362002915 H-loop/switch region; other site 1121362002916 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1121362002917 Protein of unknown function (DUF402); Region: DUF402; cl00979 1121362002918 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1121362002919 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1121362002920 G1 box; other site 1121362002921 GTP/Mg2+ binding site [chemical binding]; other site 1121362002922 G2 box; other site 1121362002923 Switch I region; other site 1121362002924 G3 box; other site 1121362002925 Switch II region; other site 1121362002926 G4 box; other site 1121362002927 G5 box; other site 1121362002928 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1121362002929 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1121362002930 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1121362002931 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1121362002932 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1121362002933 Ferredoxin [Energy production and conversion]; Region: COG1146 1121362002934 4Fe-4S binding domain; Region: Fer4; pfam00037 1121362002935 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1121362002936 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121362002937 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121362002938 homodimer interface [polypeptide binding]; other site 1121362002939 catalytic residue [active] 1121362002940 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1121362002941 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1121362002942 active site 1121362002943 Predicted membrane protein [Function unknown]; Region: COG2246 1121362002944 GtrA-like protein; Region: GtrA; pfam04138 1121362002945 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121362002946 PAS domain; Region: PAS_9; pfam13426 1121362002947 putative active site [active] 1121362002948 heme pocket [chemical binding]; other site 1121362002949 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1121362002950 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1121362002951 putative trimer interface [polypeptide binding]; other site 1121362002952 putative CoA binding site [chemical binding]; other site 1121362002953 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1121362002954 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1121362002955 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1121362002956 putative trimer interface [polypeptide binding]; other site 1121362002957 putative CoA binding site [chemical binding]; other site 1121362002958 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1121362002959 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1121362002960 metal binding site [ion binding]; metal-binding site 1121362002961 putative dimer interface [polypeptide binding]; other site 1121362002962 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1121362002963 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1121362002964 dihydropteroate synthase; Region: DHPS; TIGR01496 1121362002965 substrate binding pocket [chemical binding]; other site 1121362002966 dimer interface [polypeptide binding]; other site 1121362002967 inhibitor binding site; inhibition site 1121362002968 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 1121362002969 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1121362002970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121362002971 S-adenosylmethionine binding site [chemical binding]; other site 1121362002972 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1121362002973 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1121362002974 active site 1121362002975 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1121362002976 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1121362002977 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1121362002978 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1121362002979 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1121362002980 ligand binding site; other site 1121362002981 oligomer interface; other site 1121362002982 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1121362002983 dimer interface [polypeptide binding]; other site 1121362002984 N-terminal domain interface [polypeptide binding]; other site 1121362002985 sulfate 1 binding site; other site 1121362002986 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1121362002987 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 1121362002988 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121362002989 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121362002990 DNA binding residues [nucleotide binding] 1121362002991 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 1121362002992 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1121362002993 Domain of unknown function DUF59; Region: DUF59; pfam01883 1121362002994 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1121362002995 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1121362002996 Predicted membrane protein [Function unknown]; Region: COG4420 1121362002997 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1121362002998 MgtE intracellular N domain; Region: MgtE_N; smart00924 1121362002999 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1121362003000 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1121362003001 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1121362003002 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1121362003003 TPP-binding site [chemical binding]; other site 1121362003004 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1121362003005 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121362003006 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121362003007 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362003008 Walker A/P-loop; other site 1121362003009 ATP binding site [chemical binding]; other site 1121362003010 Q-loop/lid; other site 1121362003011 ABC transporter signature motif; other site 1121362003012 Walker B; other site 1121362003013 D-loop; other site 1121362003014 H-loop/switch region; other site 1121362003015 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121362003016 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121362003017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362003018 Walker A/P-loop; other site 1121362003019 ATP binding site [chemical binding]; other site 1121362003020 Q-loop/lid; other site 1121362003021 ABC transporter signature motif; other site 1121362003022 Walker B; other site 1121362003023 D-loop; other site 1121362003024 H-loop/switch region; other site 1121362003025 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1121362003026 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 1121362003027 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1121362003028 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1121362003029 shikimate binding site; other site 1121362003030 NAD(P) binding site [chemical binding]; other site 1121362003031 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1121362003032 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1121362003033 substrate binding pocket [chemical binding]; other site 1121362003034 catalytic triad [active] 1121362003035 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 1121362003036 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1121362003037 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1121362003038 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1121362003039 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362003040 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121362003041 putative substrate translocation pore; other site 1121362003042 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362003043 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121362003044 putative substrate translocation pore; other site 1121362003045 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1121362003046 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1121362003047 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1121362003048 CoA-ligase; Region: Ligase_CoA; pfam00549 1121362003049 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1121362003050 CoA binding domain; Region: CoA_binding; smart00881 1121362003051 CoA-ligase; Region: Ligase_CoA; pfam00549 1121362003052 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1121362003053 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 1121362003054 putative active site [active] 1121362003055 putative metal binding site [ion binding]; other site 1121362003056 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1121362003057 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1121362003058 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1121362003059 catalytic loop [active] 1121362003060 iron binding site [ion binding]; other site 1121362003061 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 1121362003062 FAD binding pocket [chemical binding]; other site 1121362003063 FAD binding motif [chemical binding]; other site 1121362003064 phosphate binding motif [ion binding]; other site 1121362003065 beta-alpha-beta structure motif; other site 1121362003066 NAD binding pocket [chemical binding]; other site 1121362003067 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1121362003068 Cytochrome P450; Region: p450; cl12078 1121362003069 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121362003070 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121362003071 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121362003072 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 1121362003073 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1121362003074 putative ligand binding site [chemical binding]; other site 1121362003075 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121362003076 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1121362003077 TM-ABC transporter signature motif; other site 1121362003078 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1121362003079 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1121362003080 Walker A/P-loop; other site 1121362003081 ATP binding site [chemical binding]; other site 1121362003082 Q-loop/lid; other site 1121362003083 ABC transporter signature motif; other site 1121362003084 Walker B; other site 1121362003085 D-loop; other site 1121362003086 H-loop/switch region; other site 1121362003087 Part of AAA domain; Region: AAA_19; pfam13245 1121362003088 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1121362003089 AAA domain; Region: AAA_12; pfam13087 1121362003090 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1121362003091 putative active site [active] 1121362003092 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 1121362003093 PLD-like domain; Region: PLDc_2; pfam13091 1121362003094 putative homodimer interface [polypeptide binding]; other site 1121362003095 putative active site [active] 1121362003096 catalytic site [active] 1121362003097 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1121362003098 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121362003099 ATP binding site [chemical binding]; other site 1121362003100 putative Mg++ binding site [ion binding]; other site 1121362003101 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121362003102 nucleotide binding region [chemical binding]; other site 1121362003103 ATP-binding site [chemical binding]; other site 1121362003104 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1121362003105 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1121362003106 active site 1121362003107 8-oxo-dGMP binding site [chemical binding]; other site 1121362003108 nudix motif; other site 1121362003109 metal binding site [ion binding]; metal-binding site 1121362003110 putative acetyltransferase; Provisional; Region: PRK03624 1121362003111 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121362003112 Coenzyme A binding pocket [chemical binding]; other site 1121362003113 Right handed beta helix region; Region: Beta_helix; pfam13229 1121362003114 agmatinase; Region: agmatinase; TIGR01230 1121362003115 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 1121362003116 putative active site [active] 1121362003117 putative metal binding site [ion binding]; other site 1121362003118 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1121362003119 helicase 45; Provisional; Region: PTZ00424 1121362003120 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1121362003121 ATP binding site [chemical binding]; other site 1121362003122 Mg++ binding site [ion binding]; other site 1121362003123 motif III; other site 1121362003124 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121362003125 nucleotide binding region [chemical binding]; other site 1121362003126 ATP-binding site [chemical binding]; other site 1121362003127 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1121362003128 putative RNA binding site [nucleotide binding]; other site 1121362003129 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1121362003130 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1121362003131 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1121362003132 Na binding site [ion binding]; other site 1121362003133 SNF2 Helicase protein; Region: DUF3670; pfam12419 1121362003134 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1121362003135 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121362003136 ATP binding site [chemical binding]; other site 1121362003137 putative Mg++ binding site [ion binding]; other site 1121362003138 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121362003139 nucleotide binding region [chemical binding]; other site 1121362003140 ATP-binding site [chemical binding]; other site 1121362003141 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1121362003142 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1121362003143 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1121362003144 hexamer interface [polypeptide binding]; other site 1121362003145 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1121362003146 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1121362003147 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1121362003148 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121362003149 motif I; other site 1121362003150 motif II; other site 1121362003151 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121362003152 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121362003153 dimerization interface [polypeptide binding]; other site 1121362003154 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121362003155 dimer interface [polypeptide binding]; other site 1121362003156 phosphorylation site [posttranslational modification] 1121362003157 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121362003158 ATP binding site [chemical binding]; other site 1121362003159 Mg2+ binding site [ion binding]; other site 1121362003160 G-X-G motif; other site 1121362003161 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121362003162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121362003163 active site 1121362003164 phosphorylation site [posttranslational modification] 1121362003165 intermolecular recognition site; other site 1121362003166 dimerization interface [polypeptide binding]; other site 1121362003167 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121362003168 DNA binding site [nucleotide binding] 1121362003169 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1121362003170 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1121362003171 active site 1121362003172 metal binding site [ion binding]; metal-binding site 1121362003173 DNA binding site [nucleotide binding] 1121362003174 AAA domain; Region: AAA_23; pfam13476 1121362003175 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362003176 Walker A/P-loop; other site 1121362003177 ATP binding site [chemical binding]; other site 1121362003178 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1121362003179 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1121362003180 MarR family; Region: MarR_2; pfam12802 1121362003181 MarR family; Region: MarR_2; cl17246 1121362003182 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 1121362003183 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1121362003184 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1121362003185 NAD(P) binding site [chemical binding]; other site 1121362003186 putative active site [active] 1121362003187 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 1121362003188 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121362003189 S-adenosylmethionine binding site [chemical binding]; other site 1121362003190 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1121362003191 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1121362003192 TAP-like protein; Region: Abhydrolase_4; pfam08386 1121362003193 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1121362003194 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1121362003195 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1121362003196 active site 1121362003197 HIGH motif; other site 1121362003198 KMSK motif region; other site 1121362003199 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1121362003200 tRNA binding surface [nucleotide binding]; other site 1121362003201 anticodon binding site; other site 1121362003202 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1121362003203 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1121362003204 active site 1121362003205 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1121362003206 substrate binding site [chemical binding]; other site 1121362003207 catalytic residues [active] 1121362003208 dimer interface [polypeptide binding]; other site 1121362003209 homoserine dehydrogenase; Provisional; Region: PRK06349 1121362003210 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1121362003211 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1121362003212 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1121362003213 homoserine kinase; Provisional; Region: PRK01212 1121362003214 Predicted transcriptional regulator [Transcription]; Region: COG2345 1121362003215 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1121362003216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121362003217 putative PBP binding loops; other site 1121362003218 ABC-ATPase subunit interface; other site 1121362003219 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362003220 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 1121362003221 Walker A/P-loop; other site 1121362003222 ATP binding site [chemical binding]; other site 1121362003223 Q-loop/lid; other site 1121362003224 ABC transporter signature motif; other site 1121362003225 Walker B; other site 1121362003226 D-loop; other site 1121362003227 H-loop/switch region; other site 1121362003228 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1121362003229 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1121362003230 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1121362003231 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1121362003232 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1121362003233 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1121362003234 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1121362003235 [4Fe-4S] binding site [ion binding]; other site 1121362003236 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1121362003237 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1121362003238 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1121362003239 molybdopterin cofactor binding site; other site 1121362003240 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1121362003241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362003242 putative substrate translocation pore; other site 1121362003243 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1121362003244 MPT binding site; other site 1121362003245 trimer interface [polypeptide binding]; other site 1121362003246 Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564 1121362003247 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1121362003248 DNA methylase; Region: N6_N4_Mtase; pfam01555 1121362003249 DNA methylase; Region: N6_N4_Mtase; pfam01555 1121362003250 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1121362003251 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1121362003252 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 1121362003253 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1121362003254 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121362003255 active site 1121362003256 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 1121362003257 trimer interface [polypeptide binding]; other site 1121362003258 dimer interface [polypeptide binding]; other site 1121362003259 putative active site [active] 1121362003260 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1121362003261 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1121362003262 dimer interface [polypeptide binding]; other site 1121362003263 putative functional site; other site 1121362003264 putative MPT binding site; other site 1121362003265 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1121362003266 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121362003267 FeS/SAM binding site; other site 1121362003268 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1121362003269 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620 1121362003270 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121362003271 acyl-activating enzyme (AAE) consensus motif; other site 1121362003272 AMP binding site [chemical binding]; other site 1121362003273 active site 1121362003274 CoA binding site [chemical binding]; other site 1121362003275 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1121362003276 transcription termination factor Rho; Provisional; Region: PRK12608 1121362003277 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1121362003278 RNA binding site [nucleotide binding]; other site 1121362003279 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1121362003280 multimer interface [polypeptide binding]; other site 1121362003281 Walker A motif; other site 1121362003282 ATP binding site [chemical binding]; other site 1121362003283 Walker B motif; other site 1121362003284 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1121362003285 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1121362003286 RF-1 domain; Region: RF-1; pfam00472 1121362003287 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1121362003288 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121362003289 S-adenosylmethionine binding site [chemical binding]; other site 1121362003290 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1121362003291 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1121362003292 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1121362003293 Mg++ binding site [ion binding]; other site 1121362003294 putative catalytic motif [active] 1121362003295 substrate binding site [chemical binding]; other site 1121362003296 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1121362003297 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1121362003298 F0F1 ATP synthase subunit C; Validated; Region: PRK07874 1121362003299 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1121362003300 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1121362003301 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1121362003302 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1121362003303 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1121362003304 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1121362003305 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1121362003306 beta subunit interaction interface [polypeptide binding]; other site 1121362003307 Walker A motif; other site 1121362003308 ATP binding site [chemical binding]; other site 1121362003309 Walker B motif; other site 1121362003310 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1121362003311 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1121362003312 core domain interface [polypeptide binding]; other site 1121362003313 delta subunit interface [polypeptide binding]; other site 1121362003314 epsilon subunit interface [polypeptide binding]; other site 1121362003315 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1121362003316 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1121362003317 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1121362003318 alpha subunit interaction interface [polypeptide binding]; other site 1121362003319 Walker A motif; other site 1121362003320 ATP binding site [chemical binding]; other site 1121362003321 Walker B motif; other site 1121362003322 inhibitor binding site; inhibition site 1121362003323 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1121362003324 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1121362003325 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1121362003326 gamma subunit interface [polypeptide binding]; other site 1121362003327 epsilon subunit interface [polypeptide binding]; other site 1121362003328 LBP interface [polypeptide binding]; other site 1121362003329 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1121362003330 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1121362003331 hypothetical protein; Provisional; Region: PRK03298 1121362003332 Domain of unknown function DUF77; Region: DUF77; pfam01910 1121362003333 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1121362003334 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1121362003335 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1121362003336 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1121362003337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121362003338 dimer interface [polypeptide binding]; other site 1121362003339 conserved gate region; other site 1121362003340 putative PBP binding loops; other site 1121362003341 ABC-ATPase subunit interface; other site 1121362003342 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1121362003343 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1121362003344 Walker A/P-loop; other site 1121362003345 ATP binding site [chemical binding]; other site 1121362003346 Q-loop/lid; other site 1121362003347 ABC transporter signature motif; other site 1121362003348 Walker B; other site 1121362003349 D-loop; other site 1121362003350 H-loop/switch region; other site 1121362003351 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1121362003352 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121362003353 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121362003354 substrate binding pocket [chemical binding]; other site 1121362003355 membrane-bound complex binding site; other site 1121362003356 hinge residues; other site 1121362003357 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 1121362003358 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1121362003359 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1121362003360 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1121362003361 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121362003362 dimerization interface [polypeptide binding]; other site 1121362003363 putative DNA binding site [nucleotide binding]; other site 1121362003364 putative Zn2+ binding site [ion binding]; other site 1121362003365 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1121362003366 arsenical-resistance protein; Region: acr3; TIGR00832 1121362003367 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1121362003368 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1121362003369 active site 1121362003370 glycogen branching enzyme; Provisional; Region: PRK05402 1121362003371 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1121362003372 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1121362003373 active site 1121362003374 catalytic site [active] 1121362003375 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1121362003376 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1121362003377 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1121362003378 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1121362003379 active site 1121362003380 catalytic site [active] 1121362003381 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1121362003382 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362003383 Walker A/P-loop; other site 1121362003384 ATP binding site [chemical binding]; other site 1121362003385 Q-loop/lid; other site 1121362003386 ABC transporter signature motif; other site 1121362003387 Walker B; other site 1121362003388 D-loop; other site 1121362003389 H-loop/switch region; other site 1121362003390 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1121362003391 Ligand binding site [chemical binding]; other site 1121362003392 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1121362003393 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1121362003394 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1121362003395 Ligand Binding Site [chemical binding]; other site 1121362003396 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1121362003397 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 1121362003398 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1121362003399 active site 1121362003400 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1121362003401 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121362003402 S-adenosylmethionine binding site [chemical binding]; other site 1121362003403 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1121362003404 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1121362003405 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121362003406 catalytic residue [active] 1121362003407 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1121362003408 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1121362003409 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1121362003410 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1121362003411 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1121362003412 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1121362003413 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1121362003414 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1121362003415 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1121362003416 NAD(P) binding site [chemical binding]; other site 1121362003417 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1121362003418 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1121362003419 active site 1121362003420 catalytic site [active] 1121362003421 substrate binding site [chemical binding]; other site 1121362003422 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1121362003423 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1121362003424 nucleotide binding pocket [chemical binding]; other site 1121362003425 K-X-D-G motif; other site 1121362003426 catalytic site [active] 1121362003427 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1121362003428 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1121362003429 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1121362003430 Dimer interface [polypeptide binding]; other site 1121362003431 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1121362003432 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1121362003433 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1121362003434 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1121362003435 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1121362003436 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121362003437 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1121362003438 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1121362003439 FAD binding pocket [chemical binding]; other site 1121362003440 FAD binding motif [chemical binding]; other site 1121362003441 phosphate binding motif [ion binding]; other site 1121362003442 NAD binding pocket [chemical binding]; other site 1121362003443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362003444 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121362003445 putative substrate translocation pore; other site 1121362003446 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1121362003447 phosphofructokinase; Region: PFK_mixed; TIGR02483 1121362003448 active site 1121362003449 ADP/pyrophosphate binding site [chemical binding]; other site 1121362003450 dimerization interface [polypeptide binding]; other site 1121362003451 allosteric effector site; other site 1121362003452 fructose-1,6-bisphosphate binding site; other site 1121362003453 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1121362003454 Sodium Bile acid symporter family; Region: SBF; pfam01758 1121362003455 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1121362003456 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1121362003457 GatB domain; Region: GatB_Yqey; smart00845 1121362003458 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1121362003459 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1121362003460 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1121362003461 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1121362003462 putative metal binding site [ion binding]; other site 1121362003463 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1121362003464 active site 1121362003465 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1121362003466 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1121362003467 active site 1121362003468 catalytic tetrad [active] 1121362003469 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1121362003470 MarR family; Region: MarR_2; pfam12802 1121362003471 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1121362003472 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1121362003473 active site 1121362003474 catalytic tetrad [active] 1121362003475 LysE type translocator; Region: LysE; cl00565 1121362003476 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1121362003477 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1121362003478 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1121362003479 dimerization interface [polypeptide binding]; other site 1121362003480 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1121362003481 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1121362003482 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1121362003483 putative dimer interface [polypeptide binding]; other site 1121362003484 N-terminal domain interface [polypeptide binding]; other site 1121362003485 putative substrate binding pocket (H-site) [chemical binding]; other site 1121362003486 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1121362003487 Predicted membrane protein [Function unknown]; Region: COG2259 1121362003488 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1121362003489 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1121362003490 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1121362003491 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1121362003492 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1121362003493 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1121362003494 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1121362003495 PYR/PP interface [polypeptide binding]; other site 1121362003496 dimer interface [polypeptide binding]; other site 1121362003497 TPP binding site [chemical binding]; other site 1121362003498 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1121362003499 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1121362003500 TPP-binding site [chemical binding]; other site 1121362003501 dimer interface [polypeptide binding]; other site 1121362003502 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1121362003503 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1121362003504 putative valine binding site [chemical binding]; other site 1121362003505 dimer interface [polypeptide binding]; other site 1121362003506 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1121362003507 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1121362003508 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1121362003509 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1121362003510 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1121362003511 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1121362003512 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1121362003513 Protein of unknown function DUF262; Region: DUF262; pfam03235 1121362003514 Uncharacterized conserved protein [Function unknown]; Region: COG3472 1121362003515 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1121362003516 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1121362003517 ligand binding site [chemical binding]; other site 1121362003518 NAD binding site [chemical binding]; other site 1121362003519 dimerization interface [polypeptide binding]; other site 1121362003520 catalytic site [active] 1121362003521 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1121362003522 putative L-serine binding site [chemical binding]; other site 1121362003523 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1121362003524 tartrate dehydrogenase; Region: TTC; TIGR02089 1121362003525 potential frameshift: common BLAST hit: gi|192290934|ref|YP_001991539.1| periplasmic binding protein 1121362003526 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1121362003527 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1121362003528 ABC-ATPase subunit interface; other site 1121362003529 dimer interface [polypeptide binding]; other site 1121362003530 putative PBP binding regions; other site 1121362003531 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1121362003532 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362003533 Walker A/P-loop; other site 1121362003534 ATP binding site [chemical binding]; other site 1121362003535 Q-loop/lid; other site 1121362003536 ABC transporter signature motif; other site 1121362003537 Walker B; other site 1121362003538 D-loop; other site 1121362003539 H-loop/switch region; other site 1121362003540 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 1121362003541 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1121362003542 ligand binding site [chemical binding]; other site 1121362003543 flexible hinge region; other site 1121362003544 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 1121362003545 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1121362003546 metal binding triad; other site 1121362003547 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1121362003548 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1121362003549 active site 1121362003550 catalytic site [active] 1121362003551 substrate binding site [chemical binding]; other site 1121362003552 Protein of unknown function, DUF488; Region: DUF488; pfam04343 1121362003553 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1121362003554 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1121362003555 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1121362003556 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1121362003557 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1121362003558 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1121362003559 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1121362003560 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1121362003561 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1121362003562 active site 1121362003563 HIGH motif; other site 1121362003564 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1121362003565 active site 1121362003566 KMSKS motif; other site 1121362003567 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121362003568 salt bridge; other site 1121362003569 non-specific DNA binding site [nucleotide binding]; other site 1121362003570 sequence-specific DNA binding site [nucleotide binding]; other site 1121362003571 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 1121362003572 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1121362003573 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121362003574 Zn2+ binding site [ion binding]; other site 1121362003575 Mg2+ binding site [ion binding]; other site 1121362003576 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1121362003577 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1121362003578 Bacterial transcriptional regulator; Region: IclR; pfam01614 1121362003579 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1121362003580 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1121362003581 substrate binding site [chemical binding]; other site 1121362003582 ligand binding site [chemical binding]; other site 1121362003583 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1121362003584 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1121362003585 substrate binding site [chemical binding]; other site 1121362003586 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1121362003587 active site 1121362003588 Ap6A binding site [chemical binding]; other site 1121362003589 nudix motif; other site 1121362003590 metal binding site [ion binding]; metal-binding site 1121362003591 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1121362003592 catalytic core [active] 1121362003593 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1121362003594 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1121362003595 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1121362003596 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1121362003597 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1121362003598 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1121362003599 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1121362003600 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1121362003601 thiamine monophosphate kinase; Provisional; Region: PRK05731 1121362003602 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1121362003603 ATP binding site [chemical binding]; other site 1121362003604 dimerization interface [polypeptide binding]; other site 1121362003605 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1121362003606 ligand binding site [chemical binding]; other site 1121362003607 active site 1121362003608 UGI interface [polypeptide binding]; other site 1121362003609 catalytic site [active] 1121362003610 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1121362003611 DAK2 domain; Region: Dak2; pfam02734 1121362003612 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1121362003613 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1121362003614 generic binding surface II; other site 1121362003615 ssDNA binding site; other site 1121362003616 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121362003617 ATP binding site [chemical binding]; other site 1121362003618 putative Mg++ binding site [ion binding]; other site 1121362003619 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121362003620 nucleotide binding region [chemical binding]; other site 1121362003621 ATP-binding site [chemical binding]; other site 1121362003622 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1121362003623 carboxyltransferase (CT) interaction site; other site 1121362003624 biotinylation site [posttranslational modification]; other site 1121362003625 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1121362003626 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121362003627 S-adenosylmethionine binding site [chemical binding]; other site 1121362003628 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1121362003629 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1121362003630 active site 1121362003631 (T/H)XGH motif; other site 1121362003632 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1121362003633 active site 1121362003634 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1121362003635 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1121362003636 Walker A/P-loop; other site 1121362003637 ATP binding site [chemical binding]; other site 1121362003638 Q-loop/lid; other site 1121362003639 ABC transporter signature motif; other site 1121362003640 Walker B; other site 1121362003641 D-loop; other site 1121362003642 H-loop/switch region; other site 1121362003643 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121362003644 dimer interface [polypeptide binding]; other site 1121362003645 conserved gate region; other site 1121362003646 putative PBP binding loops; other site 1121362003647 ABC-ATPase subunit interface; other site 1121362003648 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121362003649 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121362003650 substrate binding pocket [chemical binding]; other site 1121362003651 membrane-bound complex binding site; other site 1121362003652 hinge residues; other site 1121362003653 Domain of unknown function (DUF368); Region: DUF368; pfam04018 1121362003654 DNA polymerase I; Provisional; Region: PRK05755 1121362003655 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1121362003656 active site 1121362003657 metal binding site 1 [ion binding]; metal-binding site 1121362003658 putative 5' ssDNA interaction site; other site 1121362003659 metal binding site 3; metal-binding site 1121362003660 metal binding site 2 [ion binding]; metal-binding site 1121362003661 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1121362003662 putative DNA binding site [nucleotide binding]; other site 1121362003663 putative metal binding site [ion binding]; other site 1121362003664 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1121362003665 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1121362003666 active site 1121362003667 DNA binding site [nucleotide binding] 1121362003668 catalytic site [active] 1121362003669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121362003670 S-adenosylmethionine binding site [chemical binding]; other site 1121362003671 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1121362003672 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1121362003673 RNA binding site [nucleotide binding]; other site 1121362003674 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1121362003675 RNA binding site [nucleotide binding]; other site 1121362003676 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1121362003677 RNA binding site [nucleotide binding]; other site 1121362003678 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1121362003679 RNA binding site [nucleotide binding]; other site 1121362003680 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1121362003681 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1121362003682 active site turn [active] 1121362003683 phosphorylation site [posttranslational modification] 1121362003684 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1121362003685 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1121362003686 HPr interaction site; other site 1121362003687 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1121362003688 active site 1121362003689 phosphorylation site [posttranslational modification] 1121362003690 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1121362003691 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1121362003692 CoA-binding site [chemical binding]; other site 1121362003693 ATP-binding [chemical binding]; other site 1121362003694 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 1121362003695 excinuclease ABC subunit B; Provisional; Region: PRK05298 1121362003696 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121362003697 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121362003698 nucleotide binding region [chemical binding]; other site 1121362003699 ATP-binding site [chemical binding]; other site 1121362003700 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1121362003701 UvrB/uvrC motif; Region: UVR; pfam02151 1121362003702 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1121362003703 Ligand Binding Site [chemical binding]; other site 1121362003704 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1121362003705 Ligand Binding Site [chemical binding]; other site 1121362003706 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1121362003707 Part of AAA domain; Region: AAA_19; pfam13245 1121362003708 Family description; Region: UvrD_C_2; pfam13538 1121362003709 Predicted membrane protein [Function unknown]; Region: COG2259 1121362003710 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1121362003711 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1121362003712 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1121362003713 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1121362003714 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1121362003715 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1121362003716 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1121362003717 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1121362003718 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1121362003719 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1121362003720 23S rRNA binding site [nucleotide binding]; other site 1121362003721 L21 binding site [polypeptide binding]; other site 1121362003722 L13 binding site [polypeptide binding]; other site 1121362003723 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1121362003724 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1121362003725 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1121362003726 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1121362003727 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1121362003728 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1121362003729 dimer interface [polypeptide binding]; other site 1121362003730 motif 1; other site 1121362003731 active site 1121362003732 motif 2; other site 1121362003733 motif 3; other site 1121362003734 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1121362003735 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1121362003736 putative tRNA-binding site [nucleotide binding]; other site 1121362003737 B3/4 domain; Region: B3_4; pfam03483 1121362003738 tRNA synthetase B5 domain; Region: B5; smart00874 1121362003739 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1121362003740 dimer interface [polypeptide binding]; other site 1121362003741 motif 1; other site 1121362003742 motif 3; other site 1121362003743 motif 2; other site 1121362003744 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1121362003745 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1121362003746 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1121362003747 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1121362003748 heterotetramer interface [polypeptide binding]; other site 1121362003749 active site pocket [active] 1121362003750 cleavage site 1121362003751 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1121362003752 feedback inhibition sensing region; other site 1121362003753 homohexameric interface [polypeptide binding]; other site 1121362003754 nucleotide binding site [chemical binding]; other site 1121362003755 N-acetyl-L-glutamate binding site [chemical binding]; other site 1121362003756 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1121362003757 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1121362003758 inhibitor-cofactor binding pocket; inhibition site 1121362003759 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121362003760 catalytic residue [active] 1121362003761 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1121362003762 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1121362003763 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1121362003764 arginine repressor; Provisional; Region: PRK03341 1121362003765 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1121362003766 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1121362003767 argininosuccinate synthase; Provisional; Region: PRK13820 1121362003768 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1121362003769 ANP binding site [chemical binding]; other site 1121362003770 Substrate Binding Site II [chemical binding]; other site 1121362003771 Substrate Binding Site I [chemical binding]; other site 1121362003772 argininosuccinate lyase; Provisional; Region: PRK00855 1121362003773 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1121362003774 active sites [active] 1121362003775 tetramer interface [polypeptide binding]; other site 1121362003776 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1121362003777 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1121362003778 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1121362003779 active site 1121362003780 HIGH motif; other site 1121362003781 dimer interface [polypeptide binding]; other site 1121362003782 KMSKS motif; other site 1121362003783 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1121362003784 RNA binding surface [nucleotide binding]; other site 1121362003785 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1121362003786 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121362003787 motif II; other site 1121362003788 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121362003789 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1121362003790 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1121362003791 RNA binding surface [nucleotide binding]; other site 1121362003792 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1121362003793 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1121362003794 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1121362003795 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1121362003796 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1121362003797 Walker A/P-loop; other site 1121362003798 ATP binding site [chemical binding]; other site 1121362003799 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1121362003800 ABC transporter signature motif; other site 1121362003801 Walker B; other site 1121362003802 D-loop; other site 1121362003803 H-loop/switch region; other site 1121362003804 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1121362003805 Thiamine pyrophosphokinase; Region: TPK; cl08415 1121362003806 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1121362003807 CTP synthetase; Validated; Region: pyrG; PRK05380 1121362003808 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1121362003809 Catalytic site [active] 1121362003810 active site 1121362003811 UTP binding site [chemical binding]; other site 1121362003812 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1121362003813 active site 1121362003814 putative oxyanion hole; other site 1121362003815 catalytic triad [active] 1121362003816 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1121362003817 dimer interface [polypeptide binding]; other site 1121362003818 ADP-ribose binding site [chemical binding]; other site 1121362003819 active site 1121362003820 nudix motif; other site 1121362003821 metal binding site [ion binding]; metal-binding site 1121362003822 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1121362003823 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1121362003824 active site 1121362003825 Int/Topo IB signature motif; other site 1121362003826 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1121362003827 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362003828 Walker A/P-loop; other site 1121362003829 ATP binding site [chemical binding]; other site 1121362003830 ABC transporter signature motif; other site 1121362003831 Walker B; other site 1121362003832 D-loop; other site 1121362003833 H-loop/switch region; other site 1121362003834 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1121362003835 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1121362003836 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1121362003837 P-loop; other site 1121362003838 Magnesium ion binding site [ion binding]; other site 1121362003839 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1121362003840 Magnesium ion binding site [ion binding]; other site 1121362003841 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1121362003842 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1121362003843 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1121362003844 AAA ATPase domain; Region: AAA_16; pfam13191 1121362003845 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 1121362003846 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1121362003847 Walker A/P-loop; other site 1121362003848 ATP binding site [chemical binding]; other site 1121362003849 Q-loop/lid; other site 1121362003850 ABC transporter signature motif; other site 1121362003851 Walker B; other site 1121362003852 D-loop; other site 1121362003853 H-loop/switch region; other site 1121362003854 Predicted ATPase [General function prediction only]; Region: COG3910 1121362003855 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362003856 Walker A/P-loop; other site 1121362003857 ATP binding site [chemical binding]; other site 1121362003858 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1121362003859 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1121362003860 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1121362003861 RNA binding surface [nucleotide binding]; other site 1121362003862 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1121362003863 active site 1121362003864 cytidylate kinase; Provisional; Region: cmk; PRK00023 1121362003865 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1121362003866 CMP-binding site; other site 1121362003867 The sites determining sugar specificity; other site 1121362003868 GTP-binding protein Der; Reviewed; Region: PRK03003 1121362003869 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1121362003870 G1 box; other site 1121362003871 GTP/Mg2+ binding site [chemical binding]; other site 1121362003872 Switch I region; other site 1121362003873 G2 box; other site 1121362003874 Switch II region; other site 1121362003875 G3 box; other site 1121362003876 G4 box; other site 1121362003877 G5 box; other site 1121362003878 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1121362003879 G1 box; other site 1121362003880 GTP/Mg2+ binding site [chemical binding]; other site 1121362003881 Switch I region; other site 1121362003882 G2 box; other site 1121362003883 G3 box; other site 1121362003884 Switch II region; other site 1121362003885 G4 box; other site 1121362003886 G5 box; other site 1121362003887 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121362003888 S-adenosylmethionine binding site [chemical binding]; other site 1121362003889 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121362003890 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121362003891 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362003892 Q-loop/lid; other site 1121362003893 ABC transporter signature motif; other site 1121362003894 Walker B; other site 1121362003895 D-loop; other site 1121362003896 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121362003897 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121362003898 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362003899 Walker A/P-loop; other site 1121362003900 ATP binding site [chemical binding]; other site 1121362003901 Q-loop/lid; other site 1121362003902 ABC transporter signature motif; other site 1121362003903 Walker B; other site 1121362003904 D-loop; other site 1121362003905 H-loop/switch region; other site 1121362003906 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1121362003907 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1121362003908 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1121362003909 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1121362003910 ABC1 family; Region: ABC1; cl17513 1121362003911 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1121362003912 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1121362003913 zinc binding site [ion binding]; other site 1121362003914 putative ligand binding site [chemical binding]; other site 1121362003915 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121362003916 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 1121362003917 TM-ABC transporter signature motif; other site 1121362003918 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 1121362003919 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362003920 Walker A/P-loop; other site 1121362003921 ATP binding site [chemical binding]; other site 1121362003922 Q-loop/lid; other site 1121362003923 ABC transporter signature motif; other site 1121362003924 Walker B; other site 1121362003925 D-loop; other site 1121362003926 H-loop/switch region; other site 1121362003927 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 1121362003928 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1121362003929 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1121362003930 nucleophilic elbow; other site 1121362003931 catalytic triad; other site 1121362003932 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 1121362003933 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1121362003934 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1121362003935 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1121362003936 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1121362003937 phosphopeptide binding site; other site 1121362003938 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1121362003939 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1121362003940 DNA binding residues [nucleotide binding] 1121362003941 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1121362003942 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1121362003943 DNA binding residues [nucleotide binding] 1121362003944 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1121362003945 putative dimer interface [polypeptide binding]; other site 1121362003946 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1121362003947 Domain of unknown function DUF21; Region: DUF21; pfam01595 1121362003948 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1121362003949 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1121362003950 Domain of unknown function DUF21; Region: DUF21; pfam01595 1121362003951 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1121362003952 Transporter associated domain; Region: CorC_HlyC; smart01091 1121362003953 helicase 45; Provisional; Region: PTZ00424 1121362003954 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1121362003955 ATP binding site [chemical binding]; other site 1121362003956 putative Mg++ binding site [ion binding]; other site 1121362003957 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121362003958 nucleotide binding region [chemical binding]; other site 1121362003959 ATP-binding site [chemical binding]; other site 1121362003960 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1121362003961 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1121362003962 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1121362003963 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1121362003964 CoenzymeA binding site [chemical binding]; other site 1121362003965 subunit interaction site [polypeptide binding]; other site 1121362003966 PHB binding site; other site 1121362003967 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1121362003968 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121362003969 NAD(P) binding site [chemical binding]; other site 1121362003970 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1121362003971 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1121362003972 oligomer interface [polypeptide binding]; other site 1121362003973 metal binding site [ion binding]; metal-binding site 1121362003974 metal binding site [ion binding]; metal-binding site 1121362003975 putative Cl binding site [ion binding]; other site 1121362003976 basic sphincter; other site 1121362003977 hydrophobic gate; other site 1121362003978 periplasmic entrance; other site 1121362003979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121362003980 S-adenosylmethionine binding site [chemical binding]; other site 1121362003981 short chain dehydrogenase; Provisional; Region: PRK06701 1121362003982 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1121362003983 NAD binding site [chemical binding]; other site 1121362003984 metal binding site [ion binding]; metal-binding site 1121362003985 active site 1121362003986 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1121362003987 multifunctional hydroxymethylpyrimidine phosphokinase/4-amino-5-aminomethyl-2-methylpyrimidine hydrolase; Provisional; Region: PRK14713 1121362003988 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1121362003989 dimer interface [polypeptide binding]; other site 1121362003990 substrate binding site [chemical binding]; other site 1121362003991 ATP binding site [chemical binding]; other site 1121362003992 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1121362003993 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 1121362003994 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1121362003995 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1121362003996 active site 1121362003997 metal binding site [ion binding]; metal-binding site 1121362003998 CopC domain; Region: CopC; cl01012 1121362003999 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1121362004000 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121362004001 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121362004002 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1121362004003 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1121362004004 dimer interface [polypeptide binding]; other site 1121362004005 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1121362004006 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121362004007 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121362004008 metabolite-proton symporter; Region: 2A0106; TIGR00883 1121362004009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362004010 putative substrate translocation pore; other site 1121362004011 HicB family; Region: HicB; pfam05534 1121362004012 YceI-like domain; Region: YceI; pfam04264 1121362004013 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1121362004014 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1121362004015 Ligand binding site; other site 1121362004016 Putative Catalytic site; other site 1121362004017 DXD motif; other site 1121362004018 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1121362004019 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1121362004020 putative active site [active] 1121362004021 catalytic triad [active] 1121362004022 putative dimer interface [polypeptide binding]; other site 1121362004023 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1121362004024 Secretory lipase; Region: LIP; pfam03583 1121362004025 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1121362004026 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121362004027 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1121362004028 NAD(P) binding site [chemical binding]; other site 1121362004029 active site 1121362004030 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1121362004031 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1121362004032 putative active site [active] 1121362004033 metal binding site [ion binding]; metal-binding site 1121362004034 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1121362004035 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1121362004036 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1121362004037 active site 1121362004038 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1121362004039 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1121362004040 Predicted membrane protein (DUF2243); Region: DUF2243; cl01783 1121362004041 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1121362004042 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121362004043 ATP binding site [chemical binding]; other site 1121362004044 putative Mg++ binding site [ion binding]; other site 1121362004045 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121362004046 nucleotide binding region [chemical binding]; other site 1121362004047 ATP-binding site [chemical binding]; other site 1121362004048 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1121362004049 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1121362004050 twin arginine translocase protein A; Provisional; Region: tatA; PRK00191 1121362004051 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1121362004052 Predicted transcriptional regulator [Transcription]; Region: COG2378 1121362004053 WYL domain; Region: WYL; pfam13280 1121362004054 Predicted transcriptional regulator [Transcription]; Region: COG2378 1121362004055 WYL domain; Region: WYL; pfam13280 1121362004056 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 1121362004057 Pup-like protein; Region: Pup; cl05289 1121362004058 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 1121362004059 proteasome ATPase; Region: pup_AAA; TIGR03689 1121362004060 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121362004061 Walker A motif; other site 1121362004062 ATP binding site [chemical binding]; other site 1121362004063 Walker B motif; other site 1121362004064 arginine finger; other site 1121362004065 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1121362004066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121362004067 S-adenosylmethionine binding site [chemical binding]; other site 1121362004068 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121362004069 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121362004070 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1121362004071 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1121362004072 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1121362004073 active site 1121362004074 metal binding site [ion binding]; metal-binding site 1121362004075 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1121362004076 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1121362004077 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1121362004078 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1121362004079 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1121362004080 Potassium binding sites [ion binding]; other site 1121362004081 Cesium cation binding sites [ion binding]; other site 1121362004082 Predicted membrane protein [Function unknown]; Region: COG2149 1121362004083 Domain of unknown function (DUF202); Region: DUF202; pfam02656 1121362004084 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1121362004085 Aspartase; Region: Aspartase; cd01357 1121362004086 active sites [active] 1121362004087 tetramer interface [polypeptide binding]; other site 1121362004088 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1121362004089 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1121362004090 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1121362004091 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1121362004092 homodimer interface [polypeptide binding]; other site 1121362004093 putative metal binding site [ion binding]; other site 1121362004094 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1121362004095 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121362004096 motif II; other site 1121362004097 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1121362004098 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 1121362004099 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1121362004100 active site 1121362004101 HIGH motif; other site 1121362004102 nucleotide binding site [chemical binding]; other site 1121362004103 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1121362004104 active site 1121362004105 KMSKS motif; other site 1121362004106 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1121362004107 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 1121362004108 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1121362004109 active site 1121362004110 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1121362004111 catalytic tetrad [active] 1121362004112 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1121362004113 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1121362004114 quinone interaction residues [chemical binding]; other site 1121362004115 active site 1121362004116 catalytic residues [active] 1121362004117 FMN binding site [chemical binding]; other site 1121362004118 substrate binding site [chemical binding]; other site 1121362004119 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1121362004120 substrate binding site [chemical binding]; other site 1121362004121 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1121362004122 active site 1121362004123 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1121362004124 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1121362004125 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1121362004126 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1121362004127 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1121362004128 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1121362004129 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1121362004130 ferrochelatase; Reviewed; Region: hemH; PRK00035 1121362004131 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1121362004132 C-terminal domain interface [polypeptide binding]; other site 1121362004133 active site 1121362004134 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1121362004135 active site 1121362004136 N-terminal domain interface [polypeptide binding]; other site 1121362004137 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1121362004138 NlpC/P60 family; Region: NLPC_P60; pfam00877 1121362004139 aconitate hydratase; Validated; Region: PRK09277 1121362004140 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1121362004141 substrate binding site [chemical binding]; other site 1121362004142 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1121362004143 ligand binding site [chemical binding]; other site 1121362004144 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1121362004145 substrate binding site [chemical binding]; other site 1121362004146 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121362004147 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121362004148 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1121362004149 catalytic triad [active] 1121362004150 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121362004151 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1121362004152 NAD(P) binding site [chemical binding]; other site 1121362004153 active site 1121362004154 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 1121362004155 hypothetical protein; Validated; Region: PRK00194 1121362004156 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 1121362004157 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1121362004158 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1121362004159 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1121362004160 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1121362004161 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1121362004162 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1121362004163 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1121362004164 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362004165 Walker A/P-loop; other site 1121362004166 ATP binding site [chemical binding]; other site 1121362004167 ABC transporter signature motif; other site 1121362004168 Walker B; other site 1121362004169 D-loop; other site 1121362004170 H-loop/switch region; other site 1121362004171 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1121362004172 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1121362004173 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1121362004174 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1121362004175 trimerization site [polypeptide binding]; other site 1121362004176 active site 1121362004177 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1121362004178 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1121362004179 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121362004180 catalytic residue [active] 1121362004181 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1121362004182 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1121362004183 Walker A/P-loop; other site 1121362004184 ATP binding site [chemical binding]; other site 1121362004185 Q-loop/lid; other site 1121362004186 ABC transporter signature motif; other site 1121362004187 Walker B; other site 1121362004188 D-loop; other site 1121362004189 H-loop/switch region; other site 1121362004190 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1121362004191 FeS assembly protein SufD; Region: sufD; TIGR01981 1121362004192 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1121362004193 FeS assembly protein SufB; Region: sufB; TIGR01980 1121362004194 Predicted transcriptional regulator [Transcription]; Region: COG2345 1121362004195 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121362004196 putative DNA binding site [nucleotide binding]; other site 1121362004197 putative Zn2+ binding site [ion binding]; other site 1121362004198 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1121362004199 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1121362004200 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1121362004201 Walker A/P-loop; other site 1121362004202 ATP binding site [chemical binding]; other site 1121362004203 Q-loop/lid; other site 1121362004204 ABC transporter signature motif; other site 1121362004205 Walker B; other site 1121362004206 D-loop; other site 1121362004207 H-loop/switch region; other site 1121362004208 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1121362004209 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1121362004210 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1121362004211 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1121362004212 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1121362004213 NADP binding site [chemical binding]; other site 1121362004214 dimer interface [polypeptide binding]; other site 1121362004215 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1121362004216 UbiA prenyltransferase family; Region: UbiA; pfam01040 1121362004217 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1121362004218 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1121362004219 TPP-binding site [chemical binding]; other site 1121362004220 dimer interface [polypeptide binding]; other site 1121362004221 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1121362004222 PYR/PP interface [polypeptide binding]; other site 1121362004223 dimer interface [polypeptide binding]; other site 1121362004224 TPP binding site [chemical binding]; other site 1121362004225 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1121362004226 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1121362004227 putative active site [active] 1121362004228 transaldolase; Provisional; Region: PRK03903 1121362004229 catalytic residue [active] 1121362004230 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1121362004231 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1121362004232 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1121362004233 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1121362004234 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 1121362004235 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1121362004236 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1121362004237 putative active site [active] 1121362004238 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1121362004239 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1121362004240 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1121362004241 triosephosphate isomerase; Provisional; Region: PRK14565 1121362004242 substrate binding site [chemical binding]; other site 1121362004243 dimer interface [polypeptide binding]; other site 1121362004244 catalytic triad [active] 1121362004245 Phosphoglycerate kinase; Region: PGK; pfam00162 1121362004246 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1121362004247 substrate binding site [chemical binding]; other site 1121362004248 hinge regions; other site 1121362004249 ADP binding site [chemical binding]; other site 1121362004250 catalytic site [active] 1121362004251 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1121362004252 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1121362004253 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1121362004254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1121362004255 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1121362004256 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1121362004257 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1121362004258 phosphate binding site [ion binding]; other site 1121362004259 putative substrate binding pocket [chemical binding]; other site 1121362004260 dimer interface [polypeptide binding]; other site 1121362004261 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1121362004262 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1121362004263 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1121362004264 GIY-YIG motif/motif A; other site 1121362004265 active site 1121362004266 catalytic site [active] 1121362004267 putative DNA binding site [nucleotide binding]; other site 1121362004268 metal binding site [ion binding]; metal-binding site 1121362004269 UvrB/uvrC motif; Region: UVR; pfam02151 1121362004270 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1121362004271 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1121362004272 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1121362004273 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1121362004274 homopentamer interface [polypeptide binding]; other site 1121362004275 active site 1121362004276 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1121362004277 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1121362004278 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1121362004279 dimerization interface [polypeptide binding]; other site 1121362004280 active site 1121362004281 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1121362004282 Lumazine binding domain; Region: Lum_binding; pfam00677 1121362004283 Lumazine binding domain; Region: Lum_binding; pfam00677 1121362004284 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1121362004285 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1121362004286 catalytic motif [active] 1121362004287 Zn binding site [ion binding]; other site 1121362004288 RibD C-terminal domain; Region: RibD_C; pfam01872 1121362004289 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1121362004290 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1121362004291 substrate binding site [chemical binding]; other site 1121362004292 hexamer interface [polypeptide binding]; other site 1121362004293 metal binding site [ion binding]; metal-binding site 1121362004294 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1121362004295 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1121362004296 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1121362004297 substrate binding site [chemical binding]; other site 1121362004298 oxyanion hole (OAH) forming residues; other site 1121362004299 trimer interface [polypeptide binding]; other site 1121362004300 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1121362004301 salicylate hydroxylase; Provisional; Region: PRK08163 1121362004302 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1121362004303 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1121362004304 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1121362004305 putative RNA binding site [nucleotide binding]; other site 1121362004306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121362004307 S-adenosylmethionine binding site [chemical binding]; other site 1121362004308 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1121362004309 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1121362004310 putative active site [active] 1121362004311 substrate binding site [chemical binding]; other site 1121362004312 putative cosubstrate binding site; other site 1121362004313 catalytic site [active] 1121362004314 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1121362004315 substrate binding site [chemical binding]; other site 1121362004316 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1121362004317 active site 1121362004318 catalytic residues [active] 1121362004319 metal binding site [ion binding]; metal-binding site 1121362004320 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 1121362004321 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 1121362004322 primosome assembly protein PriA; Provisional; Region: PRK14873 1121362004323 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1121362004324 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1121362004325 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1121362004326 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1121362004327 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1121362004328 Flavoprotein; Region: Flavoprotein; pfam02441 1121362004329 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1121362004330 Predicted membrane protein [Function unknown]; Region: COG4125 1121362004331 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1121362004332 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 1121362004333 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1121362004334 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1121362004335 catalytic site [active] 1121362004336 G-X2-G-X-G-K; other site 1121362004337 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1121362004338 active site 1121362004339 dimer interface [polypeptide binding]; other site 1121362004340 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1121362004341 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1121362004342 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1121362004343 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1121362004344 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1121362004345 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1121362004346 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1121362004347 IMP binding site; other site 1121362004348 dimer interface [polypeptide binding]; other site 1121362004349 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1121362004350 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1121362004351 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1121362004352 catalytic site [active] 1121362004353 subunit interface [polypeptide binding]; other site 1121362004354 dihydroorotase; Validated; Region: pyrC; PRK09357 1121362004355 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1121362004356 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1121362004357 active site 1121362004358 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1121362004359 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1121362004360 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1121362004361 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1121362004362 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121362004363 active site 1121362004364 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1121362004365 hydrophobic ligand binding site; other site 1121362004366 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121362004367 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1121362004368 NAD(P) binding site [chemical binding]; other site 1121362004369 active site 1121362004370 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1121362004371 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 1121362004372 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1121362004373 transcription antitermination factor NusB; Region: nusB; TIGR01951 1121362004374 elongation factor P; Validated; Region: PRK00529 1121362004375 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1121362004376 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1121362004377 RNA binding site [nucleotide binding]; other site 1121362004378 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1121362004379 RNA binding site [nucleotide binding]; other site 1121362004380 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1121362004381 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1121362004382 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1121362004383 active site 1121362004384 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1121362004385 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1121362004386 trimer interface [polypeptide binding]; other site 1121362004387 active site 1121362004388 dimer interface [polypeptide binding]; other site 1121362004389 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1121362004390 active site 1121362004391 dimer interface [polypeptide binding]; other site 1121362004392 metal binding site [ion binding]; metal-binding site 1121362004393 shikimate kinase; Reviewed; Region: aroK; PRK00131 1121362004394 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1121362004395 ADP binding site [chemical binding]; other site 1121362004396 magnesium binding site [ion binding]; other site 1121362004397 putative shikimate binding site; other site 1121362004398 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1121362004399 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cl00323 1121362004400 Tetramer interface [polypeptide binding]; other site 1121362004401 active site 1121362004402 FMN-binding site [chemical binding]; other site 1121362004403 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1121362004404 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1121362004405 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1121362004406 shikimate binding site; other site 1121362004407 NAD(P) binding site [chemical binding]; other site 1121362004408 YceG-like family; Region: YceG; pfam02618 1121362004409 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 1121362004410 dimerization interface [polypeptide binding]; other site 1121362004411 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1121362004412 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1121362004413 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1121362004414 motif 1; other site 1121362004415 active site 1121362004416 motif 2; other site 1121362004417 motif 3; other site 1121362004418 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1121362004419 DHHA1 domain; Region: DHHA1; pfam02272 1121362004420 recombination factor protein RarA; Reviewed; Region: PRK13342 1121362004421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121362004422 Walker A motif; other site 1121362004423 ATP binding site [chemical binding]; other site 1121362004424 Walker B motif; other site 1121362004425 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1121362004426 Phosphotransferase enzyme family; Region: APH; pfam01636 1121362004427 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1121362004428 active site 1121362004429 ATP binding site [chemical binding]; other site 1121362004430 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1121362004431 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1121362004432 anticodon binding site; other site 1121362004433 dimer interface [polypeptide binding]; other site 1121362004434 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1121362004435 homodimer interface [polypeptide binding]; other site 1121362004436 motif 1; other site 1121362004437 active site 1121362004438 motif 2; other site 1121362004439 GAD domain; Region: GAD; pfam02938 1121362004440 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1121362004441 active site 1121362004442 motif 3; other site 1121362004443 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1121362004444 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1121362004445 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 1121362004446 NADP binding site [chemical binding]; other site 1121362004447 dimer interface [polypeptide binding]; other site 1121362004448 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121362004449 ATP binding site [chemical binding]; other site 1121362004450 putative Mg++ binding site [ion binding]; other site 1121362004451 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121362004452 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1121362004453 nucleotide binding region [chemical binding]; other site 1121362004454 ATP-binding site [chemical binding]; other site 1121362004455 Predicted membrane protein [Function unknown]; Region: COG1511 1121362004456 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1121362004457 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1121362004458 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121362004459 Predicted transcriptional regulator with C-terminal CBS domains [Transcription]; Region: COG3620 1121362004460 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1121362004461 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1121362004462 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1121362004463 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 1121362004464 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1121362004465 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1121362004466 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1121362004467 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1121362004468 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1121362004469 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1121362004470 dimer interface [polypeptide binding]; other site 1121362004471 motif 1; other site 1121362004472 active site 1121362004473 motif 2; other site 1121362004474 motif 3; other site 1121362004475 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1121362004476 anticodon binding site; other site 1121362004477 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1121362004478 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1121362004479 dimer interface [polypeptide binding]; other site 1121362004480 catalytic triad [active] 1121362004481 peroxidatic and resolving cysteines [active] 1121362004482 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1121362004483 active site 1121362004484 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1121362004485 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1121362004486 active site 1121362004487 metal binding site [ion binding]; metal-binding site 1121362004488 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1121362004489 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1121362004490 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1121362004491 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1121362004492 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121362004493 Zn2+ binding site [ion binding]; other site 1121362004494 Mg2+ binding site [ion binding]; other site 1121362004495 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1121362004496 synthetase active site [active] 1121362004497 NTP binding site [chemical binding]; other site 1121362004498 metal binding site [ion binding]; metal-binding site 1121362004499 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1121362004500 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1121362004501 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121362004502 active site 1121362004503 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1121362004504 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1121362004505 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1121362004506 Protein export membrane protein; Region: SecD_SecF; cl14618 1121362004507 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1121362004508 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1121362004509 Preprotein translocase subunit; Region: YajC; pfam02699 1121362004510 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1121362004511 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121362004512 Walker A motif; other site 1121362004513 ATP binding site [chemical binding]; other site 1121362004514 Walker B motif; other site 1121362004515 arginine finger; other site 1121362004516 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1121362004517 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1121362004518 RuvA N terminal domain; Region: RuvA_N; pfam01330 1121362004519 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1121362004520 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1121362004521 active site 1121362004522 putative DNA-binding cleft [nucleotide binding]; other site 1121362004523 dimer interface [polypeptide binding]; other site 1121362004524 hypothetical protein; Validated; Region: PRK00110 1121362004525 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1121362004526 predicted active site [active] 1121362004527 catalytic triad [active] 1121362004528 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1121362004529 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1121362004530 active site 1121362004531 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1121362004532 catalytic triad [active] 1121362004533 dimer interface [polypeptide binding]; other site 1121362004534 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1121362004535 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1121362004536 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1121362004537 active site 1121362004538 multimer interface [polypeptide binding]; other site 1121362004539 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121362004540 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1121362004541 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1121362004542 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1121362004543 putative acyl-acceptor binding pocket; other site 1121362004544 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1121362004545 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1121362004546 nucleotide binding site/active site [active] 1121362004547 HIT family signature motif; other site 1121362004548 catalytic residue [active] 1121362004549 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1121362004550 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1121362004551 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1121362004552 active site 1121362004553 dimer interface [polypeptide binding]; other site 1121362004554 motif 1; other site 1121362004555 motif 2; other site 1121362004556 motif 3; other site 1121362004557 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1121362004558 anticodon binding site; other site 1121362004559 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1121362004560 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1121362004561 CopC domain; Region: CopC; pfam04234 1121362004562 hypothetical protein; Provisional; Region: PRK14059 1121362004563 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1121362004564 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1121362004565 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1121362004566 SelR domain; Region: SelR; pfam01641 1121362004567 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1121362004568 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1121362004569 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1121362004570 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1121362004571 catalytic site [active] 1121362004572 putative active site [active] 1121362004573 putative substrate binding site [chemical binding]; other site 1121362004574 HRDC domain; Region: HRDC; pfam00570 1121362004575 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1121362004576 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1121362004577 TPP-binding site; other site 1121362004578 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1121362004579 PYR/PP interface [polypeptide binding]; other site 1121362004580 dimer interface [polypeptide binding]; other site 1121362004581 TPP binding site [chemical binding]; other site 1121362004582 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1121362004583 TRAM domain; Region: TRAM; pfam01938 1121362004584 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1121362004585 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1121362004586 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1121362004587 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1121362004588 trimer interface [polypeptide binding]; other site 1121362004589 active site 1121362004590 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1121362004591 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1121362004592 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1121362004593 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1121362004594 active site 1121362004595 dimerization interface [polypeptide binding]; other site 1121362004596 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1121362004597 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1121362004598 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1121362004599 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1121362004600 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121362004601 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1121362004602 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121362004603 DNA binding residues [nucleotide binding] 1121362004604 Protein of unknown function (DUF418); Region: DUF418; cl12135 1121362004605 Predicted membrane protein [Function unknown]; Region: COG2311 1121362004606 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1121362004607 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1121362004608 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121362004609 ATP binding site [chemical binding]; other site 1121362004610 putative Mg++ binding site [ion binding]; other site 1121362004611 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1121362004612 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1121362004613 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1121362004614 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121362004615 S-adenosylmethionine binding site [chemical binding]; other site 1121362004616 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1121362004617 putative active site [active] 1121362004618 dimerization interface [polypeptide binding]; other site 1121362004619 putative tRNAtyr binding site [nucleotide binding]; other site 1121362004620 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1121362004621 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1121362004622 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121362004623 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1121362004624 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121362004625 DNA binding residues [nucleotide binding] 1121362004626 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1121362004627 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1121362004628 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1121362004629 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1121362004630 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1121362004631 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1121362004632 NAD binding site [chemical binding]; other site 1121362004633 homodimer interface [polypeptide binding]; other site 1121362004634 active site 1121362004635 substrate binding site [chemical binding]; other site 1121362004636 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1121362004637 PAC2 family; Region: PAC2; pfam09754 1121362004638 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121362004639 ATP binding site [chemical binding]; other site 1121362004640 putative Mg++ binding site [ion binding]; other site 1121362004641 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121362004642 nucleotide binding region [chemical binding]; other site 1121362004643 ATP-binding site [chemical binding]; other site 1121362004644 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 1121362004645 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 1121362004646 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 1121362004647 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1121362004648 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1121362004649 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1121362004650 dimer interface [polypeptide binding]; other site 1121362004651 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1121362004652 catalytic triad [active] 1121362004653 peroxidatic and resolving cysteines [active] 1121362004654 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1121362004655 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1121362004656 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1121362004657 dimerization interface [polypeptide binding]; other site 1121362004658 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 1121362004659 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1121362004660 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121362004661 ATP binding site [chemical binding]; other site 1121362004662 putative Mg++ binding site [ion binding]; other site 1121362004663 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121362004664 nucleotide binding region [chemical binding]; other site 1121362004665 ATP-binding site [chemical binding]; other site 1121362004666 Helicase associated domain (HA2); Region: HA2; pfam04408 1121362004667 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1121362004668 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1121362004669 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1121362004670 ATP cone domain; Region: ATP-cone; pfam03477 1121362004671 LexA repressor; Validated; Region: PRK00215 1121362004672 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1121362004673 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1121362004674 Catalytic site [active] 1121362004675 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1121362004676 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1121362004677 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1121362004678 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1121362004679 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1121362004680 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1121362004681 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1121362004682 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1121362004683 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1121362004684 putative substrate binding site [chemical binding]; other site 1121362004685 putative ATP binding site [chemical binding]; other site 1121362004686 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1121362004687 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1121362004688 active site 1121362004689 phosphorylation site [posttranslational modification] 1121362004690 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1121362004691 active site 1121362004692 P-loop; other site 1121362004693 phosphorylation site [posttranslational modification] 1121362004694 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1121362004695 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1121362004696 dimerization domain swap beta strand [polypeptide binding]; other site 1121362004697 regulatory protein interface [polypeptide binding]; other site 1121362004698 active site 1121362004699 regulatory phosphorylation site [posttranslational modification]; other site 1121362004700 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1121362004701 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1121362004702 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1121362004703 GTPases [General function prediction only]; Region: HflX; COG2262 1121362004704 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1121362004705 HflX GTPase family; Region: HflX; cd01878 1121362004706 G1 box; other site 1121362004707 GTP/Mg2+ binding site [chemical binding]; other site 1121362004708 Switch I region; other site 1121362004709 G2 box; other site 1121362004710 G3 box; other site 1121362004711 Switch II region; other site 1121362004712 G4 box; other site 1121362004713 G5 box; other site 1121362004714 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1121362004715 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1121362004716 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1121362004717 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1121362004718 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1121362004719 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1121362004720 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1121362004721 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1121362004722 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1121362004723 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1121362004724 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121362004725 FeS/SAM binding site; other site 1121362004726 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1121362004727 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1121362004728 Walker A/P-loop; other site 1121362004729 ATP binding site [chemical binding]; other site 1121362004730 Q-loop/lid; other site 1121362004731 ABC transporter signature motif; other site 1121362004732 Walker B; other site 1121362004733 D-loop; other site 1121362004734 H-loop/switch region; other site 1121362004735 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1121362004736 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121362004737 substrate binding pocket [chemical binding]; other site 1121362004738 membrane-bound complex binding site; other site 1121362004739 hinge residues; other site 1121362004740 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121362004741 dimer interface [polypeptide binding]; other site 1121362004742 conserved gate region; other site 1121362004743 putative PBP binding loops; other site 1121362004744 ABC-ATPase subunit interface; other site 1121362004745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121362004746 dimer interface [polypeptide binding]; other site 1121362004747 conserved gate region; other site 1121362004748 putative PBP binding loops; other site 1121362004749 ABC-ATPase subunit interface; other site 1121362004750 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1121362004751 recombinase A; Provisional; Region: recA; PRK09354 1121362004752 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1121362004753 hexamer interface [polypeptide binding]; other site 1121362004754 Walker A motif; other site 1121362004755 ATP binding site [chemical binding]; other site 1121362004756 Walker B motif; other site 1121362004757 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1121362004758 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1121362004759 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1121362004760 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1121362004761 Walker A/P-loop; other site 1121362004762 ATP binding site [chemical binding]; other site 1121362004763 Q-loop/lid; other site 1121362004764 ABC transporter signature motif; other site 1121362004765 Walker B; other site 1121362004766 D-loop; other site 1121362004767 H-loop/switch region; other site 1121362004768 Cobalt transport protein; Region: CbiQ; cl00463 1121362004769 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1121362004770 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121362004771 non-specific DNA binding site [nucleotide binding]; other site 1121362004772 salt bridge; other site 1121362004773 sequence-specific DNA binding site [nucleotide binding]; other site 1121362004774 Competence-damaged protein; Region: CinA; pfam02464 1121362004775 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1121362004776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 1121362004777 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1121362004778 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1121362004779 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1121362004780 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1121362004781 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1121362004782 TIGR03085 family protein; Region: TIGR03085 1121362004783 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1121362004784 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1121362004785 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1121362004786 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1121362004787 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1121362004788 dimer interface [polypeptide binding]; other site 1121362004789 active site 1121362004790 catalytic residue [active] 1121362004791 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1121362004792 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1121362004793 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1121362004794 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1121362004795 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1121362004796 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1121362004797 AMIN domain; Region: AMIN; pfam11741 1121362004798 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1121362004799 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1121362004800 oligomer interface [polypeptide binding]; other site 1121362004801 RNA binding site [nucleotide binding]; other site 1121362004802 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1121362004803 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1121362004804 RNase E interface [polypeptide binding]; other site 1121362004805 trimer interface [polypeptide binding]; other site 1121362004806 active site 1121362004807 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1121362004808 putative nucleic acid binding region [nucleotide binding]; other site 1121362004809 G-X-X-G motif; other site 1121362004810 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1121362004811 RNA binding site [nucleotide binding]; other site 1121362004812 domain interface; other site 1121362004813 CAAX protease self-immunity; Region: Abi; cl00558 1121362004814 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1121362004815 16S/18S rRNA binding site [nucleotide binding]; other site 1121362004816 S13e-L30e interaction site [polypeptide binding]; other site 1121362004817 25S rRNA binding site [nucleotide binding]; other site 1121362004818 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 1121362004819 active site 1121362004820 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1121362004821 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1121362004822 active site 1121362004823 Riboflavin kinase; Region: Flavokinase; pfam01687 1121362004824 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1121362004825 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1121362004826 RNA binding site [nucleotide binding]; other site 1121362004827 active site 1121362004828 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1121362004829 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1121362004830 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1121362004831 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1121362004832 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1121362004833 active site 1121362004834 metal binding site [ion binding]; metal-binding site 1121362004835 putative phosphoesterase; Region: acc_ester; TIGR03729 1121362004836 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1121362004837 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1121362004838 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1121362004839 DHH family; Region: DHH; pfam01368 1121362004840 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1121362004841 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1121362004842 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1121362004843 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1121362004844 G1 box; other site 1121362004845 putative GEF interaction site [polypeptide binding]; other site 1121362004846 GTP/Mg2+ binding site [chemical binding]; other site 1121362004847 Switch I region; other site 1121362004848 G2 box; other site 1121362004849 G3 box; other site 1121362004850 Switch II region; other site 1121362004851 G4 box; other site 1121362004852 G5 box; other site 1121362004853 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1121362004854 Translation-initiation factor 2; Region: IF-2; pfam11987 1121362004855 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1121362004856 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 1121362004857 putative RNA binding cleft [nucleotide binding]; other site 1121362004858 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1121362004859 NusA N-terminal domain; Region: NusA_N; pfam08529 1121362004860 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1121362004861 RNA binding site [nucleotide binding]; other site 1121362004862 homodimer interface [polypeptide binding]; other site 1121362004863 NusA-like KH domain; Region: KH_5; pfam13184 1121362004864 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1121362004865 G-X-X-G motif; other site 1121362004866 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1121362004867 Sm and related proteins; Region: Sm_like; cl00259 1121362004868 Sm and related proteins; Region: Sm_like; cl00259 1121362004869 MMPL family; Region: MMPL; pfam03176 1121362004870 MMPL family; Region: MMPL; pfam03176 1121362004871 Predicted membrane protein [Function unknown]; Region: COG4270 1121362004872 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1121362004873 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1121362004874 putative active site [active] 1121362004875 catalytic site [active] 1121362004876 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1121362004877 putative active site [active] 1121362004878 catalytic site [active] 1121362004879 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1121362004880 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1121362004881 dimer interface [polypeptide binding]; other site 1121362004882 motif 1; other site 1121362004883 active site 1121362004884 motif 2; other site 1121362004885 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1121362004886 putative deacylase active site [active] 1121362004887 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1121362004888 active site 1121362004889 motif 3; other site 1121362004890 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1121362004891 anticodon binding site; other site 1121362004892 hypothetical protein; Validated; Region: PRK02101 1121362004893 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1121362004894 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1121362004895 Walker A/P-loop; other site 1121362004896 ATP binding site [chemical binding]; other site 1121362004897 Q-loop/lid; other site 1121362004898 ABC transporter signature motif; other site 1121362004899 Walker B; other site 1121362004900 D-loop; other site 1121362004901 H-loop/switch region; other site 1121362004902 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1121362004903 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121362004904 active site 1121362004905 phosphorylation site [posttranslational modification] 1121362004906 intermolecular recognition site; other site 1121362004907 dimerization interface [polypeptide binding]; other site 1121362004908 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1121362004909 DNA binding residues [nucleotide binding] 1121362004910 dimerization interface [polypeptide binding]; other site 1121362004911 Histidine kinase; Region: HisKA_3; pfam07730 1121362004912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121362004913 ATP binding site [chemical binding]; other site 1121362004914 Mg2+ binding site [ion binding]; other site 1121362004915 G-X-G motif; other site 1121362004916 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1121362004917 homodimer interface [polypeptide binding]; other site 1121362004918 active site 1121362004919 SAM binding site [chemical binding]; other site 1121362004920 hypothetical protein; Validated; Region: PRK00029 1121362004921 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1121362004922 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1121362004923 dimer interface [polypeptide binding]; other site 1121362004924 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1121362004925 dimer interface [polypeptide binding]; other site 1121362004926 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1121362004927 dimer interface [polypeptide binding]; other site 1121362004928 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1121362004929 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1121362004930 dimer interface [polypeptide binding]; other site 1121362004931 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121362004932 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1121362004933 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1121362004934 Walker A/P-loop; other site 1121362004935 ATP binding site [chemical binding]; other site 1121362004936 Q-loop/lid; other site 1121362004937 ABC transporter signature motif; other site 1121362004938 Walker B; other site 1121362004939 D-loop; other site 1121362004940 H-loop/switch region; other site 1121362004941 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1121362004942 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1121362004943 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1121362004944 RibD C-terminal domain; Region: RibD_C; cl17279 1121362004945 malate:quinone oxidoreductase; Validated; Region: PRK05257 1121362004946 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1121362004947 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1121362004948 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1121362004949 mycothione reductase; Reviewed; Region: PRK07846 1121362004950 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121362004951 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121362004952 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1121362004953 FtsX-like permease family; Region: FtsX; pfam02687 1121362004954 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1121362004955 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1121362004956 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1121362004957 Walker A/P-loop; other site 1121362004958 ATP binding site [chemical binding]; other site 1121362004959 Q-loop/lid; other site 1121362004960 ABC transporter signature motif; other site 1121362004961 Walker B; other site 1121362004962 D-loop; other site 1121362004963 H-loop/switch region; other site 1121362004964 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1121362004965 active site 1121362004966 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 1121362004967 putative active site [active] 1121362004968 putative metal binding site [ion binding]; other site 1121362004969 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1121362004970 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1121362004971 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1121362004972 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1121362004973 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1121362004974 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1121362004975 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1121362004976 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1121362004977 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1121362004978 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1121362004979 active site 1121362004980 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1121362004981 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1121362004982 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1121362004983 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1121362004984 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1121362004985 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1121362004986 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 1121362004987 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1121362004988 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1121362004989 Walker A/P-loop; other site 1121362004990 ATP binding site [chemical binding]; other site 1121362004991 Q-loop/lid; other site 1121362004992 ABC transporter signature motif; other site 1121362004993 Walker B; other site 1121362004994 D-loop; other site 1121362004995 H-loop/switch region; other site 1121362004996 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1121362004997 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121362004998 FeS/SAM binding site; other site 1121362004999 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1121362005000 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1121362005001 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1121362005002 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1121362005003 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1121362005004 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1121362005005 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1121362005006 hinge region; other site 1121362005007 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1121362005008 putative nucleotide binding site [chemical binding]; other site 1121362005009 uridine monophosphate binding site [chemical binding]; other site 1121362005010 homohexameric interface [polypeptide binding]; other site 1121362005011 elongation factor Ts; Provisional; Region: tsf; PRK09377 1121362005012 UBA/TS-N domain; Region: UBA; pfam00627 1121362005013 Elongation factor TS; Region: EF_TS; pfam00889 1121362005014 Elongation factor TS; Region: EF_TS; pfam00889 1121362005015 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1121362005016 rRNA interaction site [nucleotide binding]; other site 1121362005017 S8 interaction site; other site 1121362005018 putative laminin-1 binding site; other site 1121362005019 Peptidase family M23; Region: Peptidase_M23; pfam01551 1121362005020 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1121362005021 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1121362005022 active site 1121362005023 DNA binding site [nucleotide binding] 1121362005024 Int/Topo IB signature motif; other site 1121362005025 DNA protecting protein DprA; Region: dprA; TIGR00732 1121362005026 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1121362005027 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1121362005028 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1121362005029 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1121362005030 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1121362005031 hypothetical protein; Reviewed; Region: PRK12497 1121362005032 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1121362005033 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1121362005034 RNA/DNA hybrid binding site [nucleotide binding]; other site 1121362005035 active site 1121362005036 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1121362005037 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1121362005038 Catalytic site [active] 1121362005039 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1121362005040 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121362005041 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121362005042 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362005043 Walker A/P-loop; other site 1121362005044 ATP binding site [chemical binding]; other site 1121362005045 Q-loop/lid; other site 1121362005046 ABC transporter signature motif; other site 1121362005047 Walker B; other site 1121362005048 D-loop; other site 1121362005049 H-loop/switch region; other site 1121362005050 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121362005051 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 1121362005052 putative dimer interface [polypeptide binding]; other site 1121362005053 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1121362005054 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1121362005055 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1121362005056 thiamine phosphate binding site [chemical binding]; other site 1121362005057 pyrophosphate binding site [ion binding]; other site 1121362005058 active site 1121362005059 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1121362005060 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1121362005061 thiS-thiF/thiG interaction site; other site 1121362005062 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1121362005063 ThiS interaction site; other site 1121362005064 putative active site [active] 1121362005065 tetramer interface [polypeptide binding]; other site 1121362005066 thiamine biosynthesis protein ThiF; Validated; Region: PRK05600 1121362005067 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1121362005068 ATP binding site [chemical binding]; other site 1121362005069 substrate interface [chemical binding]; other site 1121362005070 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: PspE; COG0607 1121362005071 active site residue [active] 1121362005072 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1121362005073 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1121362005074 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1121362005075 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1121362005076 RNA binding site [nucleotide binding]; other site 1121362005077 PhoD-like phosphatase; Region: PhoD; pfam09423 1121362005078 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1121362005079 putative active site [active] 1121362005080 putative metal binding site [ion binding]; other site 1121362005081 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1121362005082 Protein of unknown function (DUF419); Region: DUF419; cl15265 1121362005083 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1121362005084 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 1121362005085 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1121362005086 RimM N-terminal domain; Region: RimM; pfam01782 1121362005087 PRC-barrel domain; Region: PRC; pfam05239 1121362005088 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1121362005089 Cation efflux family; Region: Cation_efflux; cl00316 1121362005090 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1121362005091 signal recognition particle protein; Provisional; Region: PRK10867 1121362005092 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1121362005093 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1121362005094 P loop; other site 1121362005095 GTP binding site [chemical binding]; other site 1121362005096 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1121362005097 PII uridylyl-transferase; Provisional; Region: glnD; PRK00227 1121362005098 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1121362005099 metal binding triad; other site 1121362005100 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1121362005101 HD domain; Region: HD; pfam01966 1121362005102 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1121362005103 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1121362005104 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1121362005105 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334 1121362005106 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 1121362005107 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 1121362005108 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 1121362005109 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1121362005110 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 1121362005111 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 1121362005112 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1121362005113 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1121362005114 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1121362005115 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1121362005116 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1121362005117 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1121362005118 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1121362005119 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1121362005120 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1121362005121 Walker A/P-loop; other site 1121362005122 ATP binding site [chemical binding]; other site 1121362005123 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1121362005124 ABC transporter signature motif; other site 1121362005125 Walker B; other site 1121362005126 D-loop; other site 1121362005127 H-loop/switch region; other site 1121362005128 acylphosphatase; Provisional; Region: PRK14422 1121362005129 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1121362005130 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1121362005131 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1121362005132 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1121362005133 DNA binding site [nucleotide binding] 1121362005134 catalytic residue [active] 1121362005135 H2TH interface [polypeptide binding]; other site 1121362005136 putative catalytic residues [active] 1121362005137 turnover-facilitating residue; other site 1121362005138 intercalation triad [nucleotide binding]; other site 1121362005139 8OG recognition residue [nucleotide binding]; other site 1121362005140 putative reading head residues; other site 1121362005141 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1121362005142 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1121362005143 ribonuclease III; Reviewed; Region: rnc; PRK00102 1121362005144 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1121362005145 dimerization interface [polypeptide binding]; other site 1121362005146 active site 1121362005147 metal binding site [ion binding]; metal-binding site 1121362005148 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1121362005149 dsRNA binding site [nucleotide binding]; other site 1121362005150 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1121362005151 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1121362005152 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1121362005153 glutamate dehydrogenase; Provisional; Region: PRK09414 1121362005154 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1121362005155 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1121362005156 NAD(P) binding site [chemical binding]; other site 1121362005157 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1121362005158 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1121362005159 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1121362005160 nucleotide binding site/active site [active] 1121362005161 HIT family signature motif; other site 1121362005162 catalytic residue [active] 1121362005163 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1121362005164 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1121362005165 metal binding site [ion binding]; metal-binding site 1121362005166 putative dimer interface [polypeptide binding]; other site 1121362005167 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1121362005168 putative homodimer interface [polypeptide binding]; other site 1121362005169 putative active site pocket [active] 1121362005170 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1121362005171 pyruvate kinase; Provisional; Region: PRK06247 1121362005172 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1121362005173 domain interfaces; other site 1121362005174 active site 1121362005175 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1121362005176 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1121362005177 active site 1121362005178 ribulose/triose binding site [chemical binding]; other site 1121362005179 phosphate binding site [ion binding]; other site 1121362005180 substrate (anthranilate) binding pocket [chemical binding]; other site 1121362005181 product (indole) binding pocket [chemical binding]; other site 1121362005182 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 1121362005183 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1121362005184 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1121362005185 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1121362005186 substrate binding site [chemical binding]; other site 1121362005187 glutamase interaction surface [polypeptide binding]; other site 1121362005188 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1121362005189 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1121362005190 active site 1121362005191 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1121362005192 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1121362005193 catalytic residues [active] 1121362005194 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1121362005195 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1121362005196 putative active site [active] 1121362005197 oxyanion strand; other site 1121362005198 catalytic triad [active] 1121362005199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362005200 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121362005201 putative substrate translocation pore; other site 1121362005202 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1121362005203 putative active site pocket [active] 1121362005204 4-fold oligomerization interface [polypeptide binding]; other site 1121362005205 metal binding residues [ion binding]; metal-binding site 1121362005206 3-fold/trimer interface [polypeptide binding]; other site 1121362005207 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1121362005208 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121362005209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121362005210 homodimer interface [polypeptide binding]; other site 1121362005211 catalytic residue [active] 1121362005212 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1121362005213 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1121362005214 NAD binding site [chemical binding]; other site 1121362005215 dimerization interface [polypeptide binding]; other site 1121362005216 product binding site; other site 1121362005217 substrate binding site [chemical binding]; other site 1121362005218 zinc binding site [ion binding]; other site 1121362005219 catalytic residues [active] 1121362005220 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1121362005221 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1121362005222 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 1121362005223 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1121362005224 dimerization interface [polypeptide binding]; other site 1121362005225 active site 1121362005226 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1121362005227 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121362005228 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1121362005229 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1121362005230 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1121362005231 active site 1121362005232 catalytic site [active] 1121362005233 Predicted transcriptional regulators [Transcription]; Region: COG1733 1121362005234 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121362005235 dimerization interface [polypeptide binding]; other site 1121362005236 putative DNA binding site [nucleotide binding]; other site 1121362005237 putative Zn2+ binding site [ion binding]; other site 1121362005238 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121362005239 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1121362005240 NAD(P) binding site [chemical binding]; other site 1121362005241 active site 1121362005242 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1121362005243 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1121362005244 active site 1121362005245 catalytic site [active] 1121362005246 substrate binding site [chemical binding]; other site 1121362005247 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 1121362005248 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1121362005249 active site 1121362005250 catalytic site [active] 1121362005251 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1121362005252 synthetase active site [active] 1121362005253 NTP binding site [chemical binding]; other site 1121362005254 metal binding site [ion binding]; metal-binding site 1121362005255 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1121362005256 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1121362005257 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1121362005258 RNA binding surface [nucleotide binding]; other site 1121362005259 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1121362005260 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1121362005261 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1121362005262 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1121362005263 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1121362005264 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1121362005265 catalytic site [active] 1121362005266 active site 1121362005267 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1121362005268 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1121362005269 threonine dehydratase; Validated; Region: PRK08639 1121362005270 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1121362005271 tetramer interface [polypeptide binding]; other site 1121362005272 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121362005273 catalytic residue [active] 1121362005274 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 1121362005275 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1121362005276 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1121362005277 substrate binding site [chemical binding]; other site 1121362005278 THF binding site; other site 1121362005279 zinc-binding site [ion binding]; other site 1121362005280 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1121362005281 substrate binding site [chemical binding]; other site 1121362005282 THF binding site; other site 1121362005283 zinc-binding site [ion binding]; other site 1121362005284 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1121362005285 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1121362005286 active site 1121362005287 PHP Thumb interface [polypeptide binding]; other site 1121362005288 metal binding site [ion binding]; metal-binding site 1121362005289 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1121362005290 generic binding surface II; other site 1121362005291 generic binding surface I; other site 1121362005292 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1121362005293 EamA-like transporter family; Region: EamA; pfam00892 1121362005294 aminoglycoside resistance protein; Provisional; Region: PRK13746 1121362005295 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1121362005296 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1121362005297 active site 1121362005298 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1121362005299 lipoprotein signal peptidase; Provisional; Region: PRK14787 1121362005300 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1121362005301 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1121362005302 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362005303 Walker A/P-loop; other site 1121362005304 Walker A/P-loop; other site 1121362005305 ATP binding site [chemical binding]; other site 1121362005306 ATP binding site [chemical binding]; other site 1121362005307 Q-loop/lid; other site 1121362005308 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1121362005309 ABC transporter signature motif; other site 1121362005310 Walker B; other site 1121362005311 D-loop; other site 1121362005312 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1121362005313 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1121362005314 active site 1121362005315 homotetramer interface [polypeptide binding]; other site 1121362005316 homodimer interface [polypeptide binding]; other site 1121362005317 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1121362005318 A new structural DNA glycosylase; Region: AlkD_like; cd06561 1121362005319 active site 1121362005320 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1121362005321 DNA polymerase IV; Provisional; Region: PRK03348 1121362005322 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1121362005323 active site 1121362005324 DNA binding site [nucleotide binding] 1121362005325 HD domain; Region: HD_4; pfam13328 1121362005326 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 1121362005327 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1121362005328 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1121362005329 HIGH motif; other site 1121362005330 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1121362005331 active site 1121362005332 KMSKS motif; other site 1121362005333 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1121362005334 tRNA binding surface [nucleotide binding]; other site 1121362005335 anticodon binding site; other site 1121362005336 DivIVA protein; Region: DivIVA; pfam05103 1121362005337 DivIVA domain; Region: DivI1A_domain; TIGR03544 1121362005338 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1121362005339 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1121362005340 Predicted integral membrane protein [Function unknown]; Region: COG0762 1121362005341 Protein of unknown function (DUF552); Region: DUF552; cl00775 1121362005342 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1121362005343 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1121362005344 catalytic residue [active] 1121362005345 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1121362005346 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1121362005347 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 1121362005348 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1121362005349 nucleotide binding site [chemical binding]; other site 1121362005350 SulA interaction site; other site 1121362005351 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1121362005352 Cell division protein FtsQ; Region: FtsQ; pfam03799 1121362005353 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1121362005354 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1121362005355 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1121362005356 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1121362005357 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1121362005358 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1121362005359 active site 1121362005360 homodimer interface [polypeptide binding]; other site 1121362005361 cell division protein FtsW; Region: ftsW; TIGR02614 1121362005362 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 1121362005363 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141 1121362005364 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1121362005365 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1121362005366 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1121362005367 Mg++ binding site [ion binding]; other site 1121362005368 putative catalytic motif [active] 1121362005369 putative substrate binding site [chemical binding]; other site 1121362005370 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1121362005371 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1121362005372 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1121362005373 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1121362005374 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1121362005375 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1121362005376 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1121362005377 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1121362005378 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1121362005379 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1121362005380 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1121362005381 MraW methylase family; Region: Methyltransf_5; cl17771 1121362005382 cell division protein MraZ; Reviewed; Region: PRK00326 1121362005383 MraZ protein; Region: MraZ; pfam02381 1121362005384 MraZ protein; Region: MraZ; pfam02381 1121362005385 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1121362005386 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121362005387 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1121362005388 Coenzyme A binding pocket [chemical binding]; other site 1121362005389 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1121362005390 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1121362005391 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1121362005392 substrate binding pocket [chemical binding]; other site 1121362005393 chain length determination region; other site 1121362005394 substrate-Mg2+ binding site; other site 1121362005395 catalytic residues [active] 1121362005396 aspartate-rich region 1; other site 1121362005397 active site lid residues [active] 1121362005398 aspartate-rich region 2; other site 1121362005399 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1121362005400 Helix-turn-helix domain; Region: HTH_17; cl17695 1121362005401 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1121362005402 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1121362005403 active site 1121362005404 ATP binding site [chemical binding]; other site 1121362005405 substrate binding site [chemical binding]; other site 1121362005406 activation loop (A-loop); other site 1121362005407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1121362005408 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1121362005409 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1121362005410 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1121362005411 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1121362005412 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1121362005413 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1121362005414 active site 1121362005415 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1121362005416 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1121362005417 Predicted membrane protein [Function unknown]; Region: COG4763 1121362005418 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1121362005419 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1121362005420 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1121362005421 putative acyl-acceptor binding pocket; other site 1121362005422 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1121362005423 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1121362005424 nucleotide binding site [chemical binding]; other site 1121362005425 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1121362005426 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121362005427 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1121362005428 NlpC/P60 family; Region: NLPC_P60; pfam00877 1121362005429 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1121362005430 NlpC/P60 family; Region: NLPC_P60; pfam00877 1121362005431 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1121362005432 heme bH binding site [chemical binding]; other site 1121362005433 intrachain domain interface; other site 1121362005434 heme bL binding site [chemical binding]; other site 1121362005435 interchain domain interface [polypeptide binding]; other site 1121362005436 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1121362005437 Qo binding site; other site 1121362005438 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1121362005439 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1121362005440 iron-sulfur cluster [ion binding]; other site 1121362005441 [2Fe-2S] cluster binding site [ion binding]; other site 1121362005442 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1121362005443 Cytochrome c; Region: Cytochrom_C; pfam00034 1121362005444 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1121362005445 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1121362005446 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1121362005447 Subunit I/III interface [polypeptide binding]; other site 1121362005448 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1121362005449 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1121362005450 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1121362005451 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1121362005452 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1121362005453 active site 1121362005454 dimer interface [polypeptide binding]; other site 1121362005455 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1121362005456 Ligand Binding Site [chemical binding]; other site 1121362005457 Molecular Tunnel; other site 1121362005458 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1121362005459 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1121362005460 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1121362005461 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1121362005462 putative dimer interface [polypeptide binding]; other site 1121362005463 active site pocket [active] 1121362005464 putative cataytic base [active] 1121362005465 Branched-chain amino acid aminotransferase; Region: DUF3665; pfam12427 1121362005466 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1121362005467 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1121362005468 homodimer interface [polypeptide binding]; other site 1121362005469 substrate-cofactor binding pocket; other site 1121362005470 catalytic residue [active] 1121362005471 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1121362005472 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1121362005473 interface (dimer of trimers) [polypeptide binding]; other site 1121362005474 Substrate-binding/catalytic site; other site 1121362005475 Zn-binding sites [ion binding]; other site 1121362005476 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 1121362005477 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1121362005478 E3 interaction surface; other site 1121362005479 lipoyl attachment site [posttranslational modification]; other site 1121362005480 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1121362005481 E3 interaction surface; other site 1121362005482 lipoyl attachment site [posttranslational modification]; other site 1121362005483 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1121362005484 E3 interaction surface; other site 1121362005485 lipoyl attachment site [posttranslational modification]; other site 1121362005486 e3 binding domain; Region: E3_binding; pfam02817 1121362005487 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1121362005488 glycine dehydrogenase; Provisional; Region: PRK05367 1121362005489 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1121362005490 tetramer interface [polypeptide binding]; other site 1121362005491 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121362005492 catalytic residue [active] 1121362005493 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1121362005494 tetramer interface [polypeptide binding]; other site 1121362005495 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121362005496 catalytic residue [active] 1121362005497 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1121362005498 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1121362005499 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1121362005500 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1121362005501 lipoyl attachment site [posttranslational modification]; other site 1121362005502 lipoate-protein ligase B; Provisional; Region: PRK14345 1121362005503 lipoyl synthase; Provisional; Region: PRK05481 1121362005504 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121362005505 FeS/SAM binding site; other site 1121362005506 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1121362005507 RDD family; Region: RDD; pfam06271 1121362005508 glutamine synthetase, type I; Region: GlnA; TIGR00653 1121362005509 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1121362005510 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1121362005511 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1121362005512 alpha-gamma subunit interface [polypeptide binding]; other site 1121362005513 beta-gamma subunit interface [polypeptide binding]; other site 1121362005514 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1121362005515 gamma-beta subunit interface [polypeptide binding]; other site 1121362005516 alpha-beta subunit interface [polypeptide binding]; other site 1121362005517 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1121362005518 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1121362005519 subunit interactions [polypeptide binding]; other site 1121362005520 active site 1121362005521 flap region; other site 1121362005522 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1121362005523 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1121362005524 dimer interface [polypeptide binding]; other site 1121362005525 catalytic residues [active] 1121362005526 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1121362005527 UreF; Region: UreF; pfam01730 1121362005528 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1121362005529 UreD urease accessory protein; Region: UreD; cl00530 1121362005530 Urea transporter; Region: UT; pfam03253 1121362005531 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1121362005532 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1121362005533 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1121362005534 ABC-ATPase subunit interface; other site 1121362005535 putative PBP binding regions; other site 1121362005536 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1121362005537 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1121362005538 intersubunit interface [polypeptide binding]; other site 1121362005539 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1121362005540 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1121362005541 Walker A/P-loop; other site 1121362005542 ATP binding site [chemical binding]; other site 1121362005543 Q-loop/lid; other site 1121362005544 ABC transporter signature motif; other site 1121362005545 Walker B; other site 1121362005546 D-loop; other site 1121362005547 H-loop/switch region; other site 1121362005548 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1121362005549 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1121362005550 active site 1121362005551 catalytic triad [active] 1121362005552 oxyanion hole [active] 1121362005553 Urea transporter; Region: UT; pfam03253 1121362005554 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1121362005555 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1121362005556 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1121362005557 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1121362005558 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121362005559 S-adenosylmethionine binding site [chemical binding]; other site 1121362005560 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1121362005561 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121362005562 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121362005563 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 1121362005564 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 1121362005565 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1121362005566 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 1121362005567 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 1121362005568 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 1121362005569 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1121362005570 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1121362005571 nudix motif; other site 1121362005572 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1121362005573 active site 1121362005574 substrate binding sites [chemical binding]; other site 1121362005575 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1121362005576 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1121362005577 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121362005578 catalytic residue [active] 1121362005579 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1121362005580 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1121362005581 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121362005582 catalytic residue [active] 1121362005583 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121362005584 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1121362005585 acyl-activating enzyme (AAE) consensus motif; other site 1121362005586 AMP binding site [chemical binding]; other site 1121362005587 active site 1121362005588 CoA binding site [chemical binding]; other site 1121362005589 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1121362005590 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 1121362005591 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1121362005592 putative trimer interface [polypeptide binding]; other site 1121362005593 putative CoA binding site [chemical binding]; other site 1121362005594 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1121362005595 putative trimer interface [polypeptide binding]; other site 1121362005596 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1121362005597 putative trimer interface [polypeptide binding]; other site 1121362005598 putative CoA binding site [chemical binding]; other site 1121362005599 Predicted membrane protein [Function unknown]; Region: COG2311 1121362005600 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 1121362005601 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1121362005602 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1121362005603 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1121362005604 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1121362005605 metal-binding site 1121362005606 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1121362005607 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1121362005608 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1121362005609 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1121362005610 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1121362005611 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1121362005612 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1121362005613 catalytic loop [active] 1121362005614 iron binding site [ion binding]; other site 1121362005615 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1121362005616 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362005617 D-galactonate transporter; Region: 2A0114; TIGR00893 1121362005618 putative substrate translocation pore; other site 1121362005619 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1121362005620 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1121362005621 metal binding triad; other site 1121362005622 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1121362005623 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1121362005624 metal binding triad; other site 1121362005625 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1121362005626 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1121362005627 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1121362005628 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1121362005629 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 1121362005630 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 1121362005631 putative active site; other site 1121362005632 putative metal binding residues [ion binding]; other site 1121362005633 signature motif; other site 1121362005634 putative triphosphate binding site [ion binding]; other site 1121362005635 CHAD domain; Region: CHAD; pfam05235 1121362005636 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1121362005637 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1121362005638 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1121362005639 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1121362005640 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1121362005641 RNB domain; Region: RNB; pfam00773 1121362005642 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 1121362005643 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1121362005644 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1121362005645 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1121362005646 hypothetical protein; Validated; Region: PRK07581 1121362005647 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1121362005648 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1121362005649 RNA/DNA hybrid binding site [nucleotide binding]; other site 1121362005650 active site 1121362005651 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1121362005652 catalytic core [active] 1121362005653 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1121362005654 Putative zinc ribbon domain; Region: DUF164; pfam02591 1121362005655 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1121362005656 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1121362005657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1121362005658 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1121362005659 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1121362005660 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121362005661 motif II; other site 1121362005662 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1121362005663 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1121362005664 active site 1121362005665 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1121362005666 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1121362005667 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1121362005668 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1121362005669 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1121362005670 dimer interface [polypeptide binding]; other site 1121362005671 TPP-binding site [chemical binding]; other site 1121362005672 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1121362005673 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1121362005674 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1121362005675 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1121362005676 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1121362005677 catalytic site [active] 1121362005678 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1121362005679 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1121362005680 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121362005681 active site 1121362005682 motif I; other site 1121362005683 motif II; other site 1121362005684 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121362005685 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 1121362005686 Methyltransferase domain; Region: Methyltransf_25; pfam13649 1121362005687 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1121362005688 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1121362005689 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1121362005690 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1121362005691 active site 1121362005692 tetramer interface [polypeptide binding]; other site 1121362005693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362005694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362005695 putative substrate translocation pore; other site 1121362005696 PIN domain; Region: PIN_3; pfam13470 1121362005697 Helix-turn-helix domain; Region: HTH_17; pfam12728 1121362005698 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1121362005699 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1121362005700 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1121362005701 active site 1121362005702 catalytic triad [active] 1121362005703 oxyanion hole [active] 1121362005704 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 1121362005705 Beta-lactamase; Region: Beta-lactamase; pfam00144 1121362005706 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1121362005707 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121362005708 acyl-activating enzyme (AAE) consensus motif; other site 1121362005709 active site 1121362005710 CoA binding site [chemical binding]; other site 1121362005711 AMP binding site [chemical binding]; other site 1121362005712 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1121362005713 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1121362005714 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1121362005715 GXWXG protein; Region: GXWXG; pfam14231 1121362005716 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 1121362005717 Predicted membrane protein [Function unknown]; Region: COG2860 1121362005718 UPF0126 domain; Region: UPF0126; pfam03458 1121362005719 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 1121362005720 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1121362005721 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1121362005722 CAAX protease self-immunity; Region: Abi; pfam02517 1121362005723 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1121362005724 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1121362005725 potential frameshift: common BLAST hit: gi|62390453|ref|YP_225855.1| superfamily II DNA/RNA helicase 1121362005726 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 1121362005727 active site 1121362005728 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 1121362005729 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1121362005730 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1121362005731 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1121362005732 Integrase core domain; Region: rve_3; pfam13683 1121362005733 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1121362005734 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1121362005735 active site 1121362005736 DNA binding site [nucleotide binding] 1121362005737 Int/Topo IB signature motif; other site 1121362005738 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1121362005739 active site 1121362005740 DNA binding site [nucleotide binding] 1121362005741 Int/Topo IB signature motif; other site 1121362005742 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1121362005743 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1121362005744 active site 1121362005745 DNA binding site [nucleotide binding] 1121362005746 Int/Topo IB signature motif; other site 1121362005747 HTH-like domain; Region: HTH_21; pfam13276 1121362005748 Integrase core domain; Region: rve; pfam00665 1121362005749 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1121362005750 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1121362005751 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362005752 ABC transporter signature motif; other site 1121362005753 Walker B; other site 1121362005754 D-loop; other site 1121362005755 H-loop/switch region; other site 1121362005756 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1121362005757 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 1121362005758 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1121362005759 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1121362005760 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1121362005761 active site 1121362005762 PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063 1121362005763 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1121362005764 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121362005765 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1121362005766 PhoD-like phosphatase; Region: PhoD; pfam09423 1121362005767 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1121362005768 putative active site [active] 1121362005769 putative metal binding site [ion binding]; other site 1121362005770 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1121362005771 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1121362005772 active site 1121362005773 DNA binding site [nucleotide binding] 1121362005774 Int/Topo IB signature motif; other site 1121362005775 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1121362005776 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1121362005777 active site 1121362005778 homodimer interface [polypeptide binding]; other site 1121362005779 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121362005780 sequence-specific DNA binding site [nucleotide binding]; other site 1121362005781 salt bridge; other site 1121362005782 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 1121362005783 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1121362005784 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1121362005785 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1121362005786 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1121362005787 DNA primase; Validated; Region: dnaG; PRK05667 1121362005788 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1121362005789 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1121362005790 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1121362005791 active site 1121362005792 metal binding site [ion binding]; metal-binding site 1121362005793 interdomain interaction site; other site 1121362005794 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1121362005795 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1121362005796 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 1121362005797 active site 1121362005798 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1121362005799 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121362005800 Zn2+ binding site [ion binding]; other site 1121362005801 Mg2+ binding site [ion binding]; other site 1121362005802 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1121362005803 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1121362005804 putative active site [active] 1121362005805 Repair protein; Region: Repair_PSII; pfam04536 1121362005806 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1121362005807 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1121362005808 motif 1; other site 1121362005809 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1121362005810 active site 1121362005811 motif 2; other site 1121362005812 motif 3; other site 1121362005813 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1121362005814 anticodon binding site; other site 1121362005815 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121362005816 putative DNA binding site [nucleotide binding]; other site 1121362005817 putative Zn2+ binding site [ion binding]; other site 1121362005818 ferric uptake regulator; Provisional; Region: fur; PRK09462 1121362005819 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1121362005820 metal binding site 2 [ion binding]; metal-binding site 1121362005821 putative DNA binding helix; other site 1121362005822 metal binding site 1 [ion binding]; metal-binding site 1121362005823 dimer interface [polypeptide binding]; other site 1121362005824 structural Zn2+ binding site [ion binding]; other site 1121362005825 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 1121362005826 diiron binding motif [ion binding]; other site 1121362005827 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 1121362005828 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829 1121362005829 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1121362005830 catalytic residue [active] 1121362005831 putative FPP diphosphate binding site; other site 1121362005832 putative FPP binding hydrophobic cleft; other site 1121362005833 dimer interface [polypeptide binding]; other site 1121362005834 putative IPP diphosphate binding site; other site 1121362005835 Recombination protein O N terminal; Region: RecO_N; pfam11967 1121362005836 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1121362005837 Recombination protein O C terminal; Region: RecO_C; pfam02565 1121362005838 GTPase Era; Reviewed; Region: era; PRK00089 1121362005839 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1121362005840 G1 box; other site 1121362005841 GTP/Mg2+ binding site [chemical binding]; other site 1121362005842 Switch I region; other site 1121362005843 G2 box; other site 1121362005844 Switch II region; other site 1121362005845 G3 box; other site 1121362005846 G4 box; other site 1121362005847 G5 box; other site 1121362005848 KH domain; Region: KH_2; pfam07650 1121362005849 pyridoxamine kinase; Validated; Region: PRK05756 1121362005850 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1121362005851 dimer interface [polypeptide binding]; other site 1121362005852 pyridoxal binding site [chemical binding]; other site 1121362005853 ATP binding site [chemical binding]; other site 1121362005854 pyridoxamine kinase; Validated; Region: PRK05756 1121362005855 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1121362005856 dimer interface [polypeptide binding]; other site 1121362005857 pyridoxal binding site [chemical binding]; other site 1121362005858 ATP binding site [chemical binding]; other site 1121362005859 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1121362005860 Domain of unknown function DUF21; Region: DUF21; pfam01595 1121362005861 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1121362005862 Transporter associated domain; Region: CorC_HlyC; smart01091 1121362005863 metal-binding heat shock protein; Provisional; Region: PRK00016 1121362005864 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1121362005865 PhoH-like protein; Region: PhoH; pfam02562 1121362005866 RNA methyltransferase, RsmE family; Region: TIGR00046 1121362005867 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 1121362005868 chaperone protein DnaJ; Provisional; Region: PRK14278 1121362005869 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1121362005870 HSP70 interaction site [polypeptide binding]; other site 1121362005871 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1121362005872 Zn binding sites [ion binding]; other site 1121362005873 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1121362005874 dimer interface [polypeptide binding]; other site 1121362005875 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1121362005876 HTH domain; Region: HTH_11; cl17392 1121362005877 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1121362005878 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121362005879 FeS/SAM binding site; other site 1121362005880 HemN C-terminal domain; Region: HemN_C; pfam06969 1121362005881 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1121362005882 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1121362005883 acyl-activating enzyme (AAE) consensus motif; other site 1121362005884 putative AMP binding site [chemical binding]; other site 1121362005885 putative active site [active] 1121362005886 putative CoA binding site [chemical binding]; other site 1121362005887 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1121362005888 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1121362005889 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1121362005890 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1121362005891 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1121362005892 active site 1121362005893 Zn binding site [ion binding]; other site 1121362005894 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1121362005895 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1121362005896 substrate binding pocket [chemical binding]; other site 1121362005897 catalytic triad [active] 1121362005898 Phosphotransferase enzyme family; Region: APH; pfam01636 1121362005899 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1121362005900 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1121362005901 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1121362005902 active site 1121362005903 metal binding site [ion binding]; metal-binding site 1121362005904 nudix motif; other site 1121362005905 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1121362005906 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121362005907 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121362005908 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1121362005909 Walker A/P-loop; other site 1121362005910 ATP binding site [chemical binding]; other site 1121362005911 Q-loop/lid; other site 1121362005912 ABC transporter signature motif; other site 1121362005913 Walker B; other site 1121362005914 D-loop; other site 1121362005915 H-loop/switch region; other site 1121362005916 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1121362005917 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121362005918 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121362005919 homodimer interface [polypeptide binding]; other site 1121362005920 catalytic residue [active] 1121362005921 trehalose synthase; Region: treS_nterm; TIGR02456 1121362005922 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1121362005923 active site 1121362005924 catalytic site [active] 1121362005925 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1121362005926 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1121362005927 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1121362005928 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1121362005929 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1121362005930 Protein of unknown function (DUF3792); Region: DUF3792; cl14821 1121362005931 BCCT family transporter; Region: BCCT; pfam02028 1121362005932 Predicted permeases [General function prediction only]; Region: COG0679 1121362005933 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1121362005934 FAD binding domain; Region: FAD_binding_4; pfam01565 1121362005935 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1121362005936 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 1121362005937 catalytic Zn binding site [ion binding]; other site 1121362005938 putative phosphonate catabolism associated alcohol dehydrogenase; Region: HpnZ_proposed; TIGR03366 1121362005939 structural Zn binding site [ion binding]; other site 1121362005940 tetramer interface [polypeptide binding]; other site 1121362005941 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1121362005942 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121362005943 motif II; other site 1121362005944 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1121362005945 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1121362005946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1121362005947 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362005948 ABC transporter; Region: ABC_tran; pfam00005 1121362005949 Q-loop/lid; other site 1121362005950 ABC transporter signature motif; other site 1121362005951 Walker B; other site 1121362005952 D-loop; other site 1121362005953 H-loop/switch region; other site 1121362005954 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1121362005955 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121362005956 substrate binding pocket [chemical binding]; other site 1121362005957 membrane-bound complex binding site; other site 1121362005958 hinge residues; other site 1121362005959 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 1121362005960 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1121362005961 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1121362005962 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121362005963 DNA-binding site [nucleotide binding]; DNA binding site 1121362005964 UTRA domain; Region: UTRA; pfam07702 1121362005965 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1121362005966 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121362005967 DNA-binding site [nucleotide binding]; DNA binding site 1121362005968 UTRA domain; Region: UTRA; cl17743 1121362005969 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1121362005970 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 1121362005971 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1121362005972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121362005973 dimer interface [polypeptide binding]; other site 1121362005974 conserved gate region; other site 1121362005975 ABC-ATPase subunit interface; other site 1121362005976 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1121362005977 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121362005978 dimer interface [polypeptide binding]; other site 1121362005979 conserved gate region; other site 1121362005980 putative PBP binding loops; other site 1121362005981 ABC-ATPase subunit interface; other site 1121362005982 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1121362005983 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1121362005984 Walker A/P-loop; other site 1121362005985 ATP binding site [chemical binding]; other site 1121362005986 Q-loop/lid; other site 1121362005987 ABC transporter signature motif; other site 1121362005988 Walker B; other site 1121362005989 D-loop; other site 1121362005990 H-loop/switch region; other site 1121362005991 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1121362005992 Walker A/P-loop; other site 1121362005993 ATP binding site [chemical binding]; other site 1121362005994 ABC transporter signature motif; other site 1121362005995 Walker B; other site 1121362005996 D-loop; other site 1121362005997 H-loop/switch region; other site 1121362005998 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1121362005999 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1121362006000 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1121362006001 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1121362006002 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1121362006003 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1121362006004 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1121362006005 DNA binding site [nucleotide binding] 1121362006006 domain linker motif; other site 1121362006007 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1121362006008 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1121362006009 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1121362006010 Walker A/P-loop; other site 1121362006011 ATP binding site [chemical binding]; other site 1121362006012 Q-loop/lid; other site 1121362006013 ABC transporter signature motif; other site 1121362006014 Walker B; other site 1121362006015 D-loop; other site 1121362006016 H-loop/switch region; other site 1121362006017 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1121362006018 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121362006019 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1121362006020 TM-ABC transporter signature motif; other site 1121362006021 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1121362006022 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1121362006023 ligand binding site [chemical binding]; other site 1121362006024 dimerization interface [polypeptide binding]; other site 1121362006025 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 1121362006026 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1121362006027 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1121362006028 substrate binding site [chemical binding]; other site 1121362006029 dimer interface [polypeptide binding]; other site 1121362006030 ATP binding site [chemical binding]; other site 1121362006031 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1121362006032 active site 1121362006033 phosphorylation site [posttranslational modification] 1121362006034 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1121362006035 active site 1121362006036 P-loop; other site 1121362006037 phosphorylation site [posttranslational modification] 1121362006038 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1121362006039 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1121362006040 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121362006041 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1121362006042 Sodium Bile acid symporter family; Region: SBF; pfam01758 1121362006043 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1121362006044 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1121362006045 active site 1121362006046 phosphate binding residues; other site 1121362006047 catalytic residues [active] 1121362006048 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 1121362006049 Sulphur transport; Region: Sulf_transp; pfam04143 1121362006050 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1121362006051 CPxP motif; other site 1121362006052 Predicted membrane protein [Function unknown]; Region: COG1289 1121362006053 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1121362006054 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1121362006055 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1121362006056 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1121362006057 active site 1121362006058 metal binding site [ion binding]; metal-binding site 1121362006059 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1121362006060 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1121362006061 catalytic residues [active] 1121362006062 BCCT family transporter; Region: BCCT; pfam02028 1121362006063 META domain; Region: META; pfam03724 1121362006064 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1121362006065 Putative esterase; Region: Esterase; pfam00756 1121362006066 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1121362006067 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121362006068 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121362006069 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362006070 Walker A/P-loop; other site 1121362006071 ATP binding site [chemical binding]; other site 1121362006072 Q-loop/lid; other site 1121362006073 ABC transporter signature motif; other site 1121362006074 Walker B; other site 1121362006075 D-loop; other site 1121362006076 H-loop/switch region; other site 1121362006077 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121362006078 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121362006079 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362006080 Q-loop/lid; other site 1121362006081 ABC transporter signature motif; other site 1121362006082 Walker B; other site 1121362006083 D-loop; other site 1121362006084 H-loop/switch region; other site 1121362006085 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1121362006086 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1121362006087 Walker A/P-loop; other site 1121362006088 ATP binding site [chemical binding]; other site 1121362006089 Q-loop/lid; other site 1121362006090 ABC transporter signature motif; other site 1121362006091 Walker B; other site 1121362006092 D-loop; other site 1121362006093 H-loop/switch region; other site 1121362006094 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1121362006095 ABC-ATPase subunit interface; other site 1121362006096 dimer interface [polypeptide binding]; other site 1121362006097 putative PBP binding regions; other site 1121362006098 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1121362006099 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1121362006100 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1121362006101 dimer interface [polypeptide binding]; other site 1121362006102 putative PBP binding regions; other site 1121362006103 ABC-ATPase subunit interface; other site 1121362006104 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1121362006105 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1121362006106 intersubunit interface [polypeptide binding]; other site 1121362006107 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1121362006108 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1121362006109 nucleotide binding site [chemical binding]; other site 1121362006110 proline/glycine betaine transporter; Provisional; Region: PRK10642 1121362006111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362006112 putative substrate translocation pore; other site 1121362006113 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 1121362006114 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1121362006115 GTP-binding protein LepA; Provisional; Region: PRK05433 1121362006116 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1121362006117 G1 box; other site 1121362006118 putative GEF interaction site [polypeptide binding]; other site 1121362006119 GTP/Mg2+ binding site [chemical binding]; other site 1121362006120 Switch I region; other site 1121362006121 G2 box; other site 1121362006122 G3 box; other site 1121362006123 Switch II region; other site 1121362006124 G4 box; other site 1121362006125 G5 box; other site 1121362006126 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1121362006127 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1121362006128 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1121362006129 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1121362006130 dimanganese center [ion binding]; other site 1121362006131 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121362006132 Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369 1121362006133 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 1121362006134 PemK-like protein; Region: PemK; pfam02452 1121362006135 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1121362006136 LysE type translocator; Region: LysE; cl00565 1121362006137 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1121362006138 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1121362006139 hypothetical protein; Validated; Region: PRK05629 1121362006140 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1121362006141 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1121362006142 Competence protein; Region: Competence; pfam03772 1121362006143 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1121362006144 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1121362006145 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 1121362006146 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1121362006147 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1121362006148 catalytic core [active] 1121362006149 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1121362006150 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1121362006151 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1121362006152 active site 1121362006153 (T/H)XGH motif; other site 1121362006154 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1121362006155 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1121362006156 putative catalytic cysteine [active] 1121362006157 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1121362006158 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 1121362006159 putative ligand binding site [chemical binding]; other site 1121362006160 putative NAD binding site [chemical binding]; other site 1121362006161 catalytic site [active] 1121362006162 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 1121362006163 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1121362006164 putative ligand binding site [chemical binding]; other site 1121362006165 putative NAD binding site [chemical binding]; other site 1121362006166 catalytic site [active] 1121362006167 gamma-glutamyl kinase; Provisional; Region: PRK05429 1121362006168 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1121362006169 nucleotide binding site [chemical binding]; other site 1121362006170 homotetrameric interface [polypeptide binding]; other site 1121362006171 putative phosphate binding site [ion binding]; other site 1121362006172 putative allosteric binding site; other site 1121362006173 PUA domain; Region: PUA; pfam01472 1121362006174 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1121362006175 GTP1/OBG; Region: GTP1_OBG; pfam01018 1121362006176 Obg GTPase; Region: Obg; cd01898 1121362006177 G1 box; other site 1121362006178 GTP/Mg2+ binding site [chemical binding]; other site 1121362006179 Switch I region; other site 1121362006180 G2 box; other site 1121362006181 G3 box; other site 1121362006182 Switch II region; other site 1121362006183 G4 box; other site 1121362006184 G5 box; other site 1121362006185 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1121362006186 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1121362006187 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1121362006188 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1121362006189 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1121362006190 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1121362006191 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1121362006192 homodimer interface [polypeptide binding]; other site 1121362006193 oligonucleotide binding site [chemical binding]; other site 1121362006194 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1121362006195 active site 1121362006196 multimer interface [polypeptide binding]; other site 1121362006197 Pirin-related protein [General function prediction only]; Region: COG1741 1121362006198 Pirin; Region: Pirin; pfam02678 1121362006199 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1121362006200 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1121362006201 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1121362006202 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1121362006203 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1121362006204 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1121362006205 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1121362006206 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1121362006207 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1121362006208 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1121362006209 active site 1121362006210 HIGH motif; other site 1121362006211 nucleotide binding site [chemical binding]; other site 1121362006212 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1121362006213 active site 1121362006214 KMSKS motif; other site 1121362006215 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1121362006216 tRNA binding surface [nucleotide binding]; other site 1121362006217 anticodon binding site; other site 1121362006218 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1121362006219 malate dehydrogenase; Provisional; Region: PRK05442 1121362006220 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1121362006221 NAD(P) binding site [chemical binding]; other site 1121362006222 dimer interface [polypeptide binding]; other site 1121362006223 malate binding site [chemical binding]; other site 1121362006224 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121362006225 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121362006226 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1121362006227 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 1121362006228 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1121362006229 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121362006230 Walker A motif; other site 1121362006231 ATP binding site [chemical binding]; other site 1121362006232 Walker B motif; other site 1121362006233 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1121362006234 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1121362006235 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1121362006236 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1121362006237 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1121362006238 Bacterial transcriptional regulator; Region: IclR; pfam01614 1121362006239 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 1121362006240 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1121362006241 dimer interface [polypeptide binding]; other site 1121362006242 active site 1121362006243 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1121362006244 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 1121362006245 benzoate transporter; Region: benE; TIGR00843 1121362006246 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1121362006247 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1121362006248 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1121362006249 DNA binding residues [nucleotide binding] 1121362006250 dimerization interface [polypeptide binding]; other site 1121362006251 benzoate transport; Region: 2A0115; TIGR00895 1121362006252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362006253 putative substrate translocation pore; other site 1121362006254 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1121362006255 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121362006256 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1121362006257 3-carboxy-cis,cis-muconate cycloisomerase; Region: protocat_pcaB; TIGR02426 1121362006258 tetramer interface [polypeptide binding]; other site 1121362006259 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 1121362006260 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1121362006261 active site 1121362006262 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1121362006263 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1121362006264 active site 1121362006265 benzoate transport; Region: 2A0115; TIGR00895 1121362006266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362006267 putative substrate translocation pore; other site 1121362006268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362006269 Muconolactone delta-isomerase; Region: MIase; cl01992 1121362006270 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1121362006271 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 1121362006272 metal binding site [ion binding]; metal-binding site 1121362006273 substrate binding pocket [chemical binding]; other site 1121362006274 catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438 1121362006275 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1121362006276 active site 1121362006277 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 1121362006278 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1121362006279 iron-sulfur cluster [ion binding]; other site 1121362006280 [2Fe-2S] cluster binding site [ion binding]; other site 1121362006281 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1121362006282 putative alpha subunit interface [polypeptide binding]; other site 1121362006283 putative active site [active] 1121362006284 putative substrate binding site [chemical binding]; other site 1121362006285 Fe binding site [ion binding]; other site 1121362006286 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1121362006287 inter-subunit interface; other site 1121362006288 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 1121362006289 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1121362006290 catalytic loop [active] 1121362006291 iron binding site [ion binding]; other site 1121362006292 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 1121362006293 FAD binding pocket [chemical binding]; other site 1121362006294 FAD binding motif [chemical binding]; other site 1121362006295 phosphate binding motif [ion binding]; other site 1121362006296 beta-alpha-beta structure motif; other site 1121362006297 NAD binding pocket [chemical binding]; other site 1121362006298 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1121362006299 FCD domain; Region: FCD; pfam07729 1121362006300 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 1121362006301 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121362006302 NAD(P) binding site [chemical binding]; other site 1121362006303 active site 1121362006304 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121362006305 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1121362006306 Walker A motif; other site 1121362006307 ATP binding site [chemical binding]; other site 1121362006308 Walker B motif; other site 1121362006309 arginine finger; other site 1121362006310 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1121362006311 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1121362006312 DNA binding residues [nucleotide binding] 1121362006313 dimerization interface [polypeptide binding]; other site 1121362006314 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1121362006315 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1121362006316 oligomer interface [polypeptide binding]; other site 1121362006317 active site residues [active] 1121362006318 Clp protease; Region: CLP_protease; pfam00574 1121362006319 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1121362006320 oligomer interface [polypeptide binding]; other site 1121362006321 active site residues [active] 1121362006322 trigger factor; Provisional; Region: tig; PRK01490 1121362006323 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1121362006324 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1121362006325 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1121362006326 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1121362006327 active site 1121362006328 catalytic tetrad [active] 1121362006329 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1121362006330 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1121362006331 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1121362006332 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1121362006333 OsmC-like protein; Region: OsmC; pfam02566 1121362006334 NMT1-like family; Region: NMT1_2; pfam13379 1121362006335 NMT1/THI5 like; Region: NMT1; pfam09084 1121362006336 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1121362006337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121362006338 dimer interface [polypeptide binding]; other site 1121362006339 conserved gate region; other site 1121362006340 putative PBP binding loops; other site 1121362006341 ABC-ATPase subunit interface; other site 1121362006342 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1121362006343 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1121362006344 Walker A/P-loop; other site 1121362006345 ATP binding site [chemical binding]; other site 1121362006346 Q-loop/lid; other site 1121362006347 ABC transporter signature motif; other site 1121362006348 Walker B; other site 1121362006349 D-loop; other site 1121362006350 H-loop/switch region; other site 1121362006351 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 1121362006352 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1121362006353 protein-splicing catalytic site; other site 1121362006354 thioester formation/cholesterol transfer; other site 1121362006355 HNH endonuclease; Region: HNH_3; pfam13392 1121362006356 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 1121362006357 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1121362006358 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1121362006359 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1121362006360 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1121362006361 Zn binding site [ion binding]; other site 1121362006362 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1121362006363 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1121362006364 active site 1121362006365 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1121362006366 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1121362006367 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121362006368 dimerization interface [polypeptide binding]; other site 1121362006369 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121362006370 dimer interface [polypeptide binding]; other site 1121362006371 phosphorylation site [posttranslational modification] 1121362006372 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121362006373 ATP binding site [chemical binding]; other site 1121362006374 Mg2+ binding site [ion binding]; other site 1121362006375 G-X-G motif; other site 1121362006376 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121362006377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121362006378 active site 1121362006379 phosphorylation site [posttranslational modification] 1121362006380 intermolecular recognition site; other site 1121362006381 dimerization interface [polypeptide binding]; other site 1121362006382 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121362006383 DNA binding site [nucleotide binding] 1121362006384 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1121362006385 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121362006386 DNA-binding site [nucleotide binding]; DNA binding site 1121362006387 UTRA domain; Region: UTRA; pfam07702 1121362006388 CMD domain protein, Avi_7170 family; Region: CMD_Avi_7170; TIGR04029 1121362006389 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1121362006390 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1121362006391 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1121362006392 short chain dehydrogenase; Provisional; Region: PRK08219 1121362006393 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121362006394 NAD(P) binding site [chemical binding]; other site 1121362006395 active site 1121362006396 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1121362006397 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1121362006398 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 1121362006399 cystathionine gamma-synthase; Provisional; Region: PRK07811 1121362006400 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1121362006401 homodimer interface [polypeptide binding]; other site 1121362006402 substrate-cofactor binding pocket; other site 1121362006403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121362006404 catalytic residue [active] 1121362006405 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1121362006406 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362006407 Walker A/P-loop; other site 1121362006408 ATP binding site [chemical binding]; other site 1121362006409 Q-loop/lid; other site 1121362006410 ABC transporter signature motif; other site 1121362006411 Walker B; other site 1121362006412 D-loop; other site 1121362006413 H-loop/switch region; other site 1121362006414 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1121362006415 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1121362006416 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1121362006417 apolar tunnel; other site 1121362006418 heme binding site [chemical binding]; other site 1121362006419 dimerization interface [polypeptide binding]; other site 1121362006420 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1121362006421 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1121362006422 hexamer interface [polypeptide binding]; other site 1121362006423 ligand binding site [chemical binding]; other site 1121362006424 putative active site [active] 1121362006425 NAD(P) binding site [chemical binding]; other site 1121362006426 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1121362006427 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 1121362006428 Chromate transporter; Region: Chromate_transp; pfam02417 1121362006429 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1121362006430 active site 1121362006431 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1121362006432 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362006433 Walker A/P-loop; other site 1121362006434 ATP binding site [chemical binding]; other site 1121362006435 Q-loop/lid; other site 1121362006436 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1121362006437 ABC transporter; Region: ABC_tran_2; pfam12848 1121362006438 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1121362006439 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1121362006440 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1121362006441 dimer interface [polypeptide binding]; other site 1121362006442 ssDNA binding site [nucleotide binding]; other site 1121362006443 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1121362006444 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1121362006445 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1121362006446 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121362006447 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1121362006448 NAD(P) binding site [chemical binding]; other site 1121362006449 active site 1121362006450 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1121362006451 classical (c) SDRs; Region: SDR_c; cd05233 1121362006452 NAD(P) binding site [chemical binding]; other site 1121362006453 active site 1121362006454 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1121362006455 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1121362006456 catalytic site [active] 1121362006457 putative active site [active] 1121362006458 putative substrate binding site [chemical binding]; other site 1121362006459 dimer interface [polypeptide binding]; other site 1121362006460 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1121362006461 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 1121362006462 putative NAD(P) binding site [chemical binding]; other site 1121362006463 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1121362006464 Protein of unknown function (DUF419); Region: DUF419; pfam04237 1121362006465 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1121362006466 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1121362006467 potential frameshift: common BLAST hit: gi|62390970|ref|YP_226372.1| dehydrogenase 1121362006468 oxidoreductase; Provisional; Region: PRK06128 1121362006469 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121362006470 NAD(P) binding site [chemical binding]; other site 1121362006471 active site 1121362006472 oxidoreductase; Provisional; Region: PRK06128 1121362006473 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121362006474 NAD(P) binding site [chemical binding]; other site 1121362006475 active site 1121362006476 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1121362006477 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121362006478 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 1121362006479 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1121362006480 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1121362006481 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1121362006482 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1121362006483 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 1121362006484 glutaminase; Provisional; Region: PRK00971 1121362006485 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1121362006486 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 1121362006487 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1121362006488 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1121362006489 DNA binding site [nucleotide binding] 1121362006490 domain linker motif; other site 1121362006491 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1121362006492 dimerization interface [polypeptide binding]; other site 1121362006493 ligand binding site [chemical binding]; other site 1121362006494 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1121362006495 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1121362006496 tetramer interface [polypeptide binding]; other site 1121362006497 active site 1121362006498 Mg2+/Mn2+ binding site [ion binding]; other site 1121362006499 glucuronate isomerase; Reviewed; Region: PRK02925 1121362006500 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1121362006501 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1121362006502 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1121362006503 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1121362006504 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 1121362006505 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1121362006506 metal binding site [ion binding]; metal-binding site 1121362006507 substrate binding pocket [chemical binding]; other site 1121362006508 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1121362006509 AAA domain; Region: AAA_33; pfam13671 1121362006510 ATP-binding site [chemical binding]; other site 1121362006511 Gluconate-6-phosphate binding site [chemical binding]; other site 1121362006512 hypothetical protein; Provisional; Region: PRK06185 1121362006513 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1121362006514 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1121362006515 Isochorismatase family; Region: Isochorismatase; pfam00857 1121362006516 catalytic triad [active] 1121362006517 metal binding site [ion binding]; metal-binding site 1121362006518 conserved cis-peptide bond; other site 1121362006519 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1121362006520 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1121362006521 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1121362006522 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1121362006523 catalytic triad [active] 1121362006524 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121362006525 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121362006526 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1121362006527 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1121362006528 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1121362006529 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1121362006530 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1121362006531 phosphate binding site [ion binding]; other site 1121362006532 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1121362006533 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1121362006534 active site 2 [active] 1121362006535 active site 1 [active] 1121362006536 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1121362006537 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1121362006538 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1121362006539 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1121362006540 putative NAD(P) binding site [chemical binding]; other site 1121362006541 active site 1121362006542 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1121362006543 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1121362006544 active site 1121362006545 Glucitol operon activator protein (GutM); Region: GutM; cl01890 1121362006546 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1121362006547 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1121362006548 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1121362006549 catalytic residue [active] 1121362006550 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1121362006551 active site 1121362006552 dimerization interface [polypeptide binding]; other site 1121362006553 ribonuclease PH; Reviewed; Region: rph; PRK00173 1121362006554 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1121362006555 hexamer interface [polypeptide binding]; other site 1121362006556 active site 1121362006557 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1121362006558 glutamate racemase; Provisional; Region: PRK00865 1121362006559 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1121362006560 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1121362006561 Rhomboid family; Region: Rhomboid; cl11446 1121362006562 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1121362006563 putative active site pocket [active] 1121362006564 cleavage site 1121362006565 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1121362006566 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1121362006567 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1121362006568 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1121362006569 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1121362006570 active site 1121362006571 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1121362006572 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1121362006573 ATP binding site [chemical binding]; other site 1121362006574 DEAD_2; Region: DEAD_2; pfam06733 1121362006575 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1121362006576 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1121362006577 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1121362006578 ligand binding site [chemical binding]; other site 1121362006579 flexible hinge region; other site 1121362006580 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1121362006581 putative switch regulator; other site 1121362006582 non-specific DNA interactions [nucleotide binding]; other site 1121362006583 DNA binding site [nucleotide binding] 1121362006584 sequence specific DNA binding site [nucleotide binding]; other site 1121362006585 putative cAMP binding site [chemical binding]; other site 1121362006586 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1121362006587 metal-binding site [ion binding] 1121362006588 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1121362006589 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1121362006590 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121362006591 motif II; other site 1121362006592 Peptidyl-tRNA hydrolase [Translation, ribosomal structure and biogenesis]; Region: pth2; cl17334 1121362006593 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1121362006594 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1121362006595 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1121362006596 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121362006597 motif II; other site 1121362006598 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1121362006599 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1121362006600 D-pathway; other site 1121362006601 Putative ubiquinol binding site [chemical binding]; other site 1121362006602 Low-spin heme (heme b) binding site [chemical binding]; other site 1121362006603 Putative water exit pathway; other site 1121362006604 Binuclear center (heme o3/CuB) [ion binding]; other site 1121362006605 K-pathway; other site 1121362006606 Putative proton exit pathway; other site 1121362006607 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1121362006608 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121362006609 DNA-binding site [nucleotide binding]; DNA binding site 1121362006610 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1121362006611 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1121362006612 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1121362006613 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1121362006614 active site 1121362006615 dimer interface [polypeptide binding]; other site 1121362006616 catalytic residues [active] 1121362006617 effector binding site; other site 1121362006618 R2 peptide binding site; other site 1121362006619 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1121362006620 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1121362006621 catalytic residues [active] 1121362006622 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1121362006623 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1121362006624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362006625 putative substrate translocation pore; other site 1121362006626 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1121362006627 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1121362006628 homodimer interface [polypeptide binding]; other site 1121362006629 NAD binding pocket [chemical binding]; other site 1121362006630 ATP binding pocket [chemical binding]; other site 1121362006631 Mg binding site [ion binding]; other site 1121362006632 active-site loop [active] 1121362006633 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1121362006634 Phosphotransferase enzyme family; Region: APH; pfam01636 1121362006635 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1121362006636 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1121362006637 catalytic tetrad [active] 1121362006638 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1121362006639 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1121362006640 catalytic residues [active] 1121362006641 Predicted membrane protein [Function unknown]; Region: COG2259 1121362006642 phosphoglucomutase; Validated; Region: PRK07564 1121362006643 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1121362006644 active site 1121362006645 substrate binding site [chemical binding]; other site 1121362006646 metal binding site [ion binding]; metal-binding site 1121362006647 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1121362006648 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1121362006649 CrcB-like protein; Region: CRCB; cl09114 1121362006650 CrcB-like protein; Region: CRCB; pfam02537 1121362006651 FtsX-like permease family; Region: FtsX; pfam02687 1121362006652 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1121362006653 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1121362006654 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1121362006655 FtsX-like permease family; Region: FtsX; pfam02687 1121362006656 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1121362006657 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1121362006658 Walker A/P-loop; other site 1121362006659 ATP binding site [chemical binding]; other site 1121362006660 Q-loop/lid; other site 1121362006661 ABC transporter signature motif; other site 1121362006662 Walker B; other site 1121362006663 D-loop; other site 1121362006664 H-loop/switch region; other site 1121362006665 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1121362006666 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1121362006667 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1121362006668 hinge; other site 1121362006669 active site 1121362006670 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1121362006671 GAF domain; Region: GAF_2; pfam13185 1121362006672 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1121362006673 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1121362006674 DNA binding residues [nucleotide binding] 1121362006675 dimerization interface [polypeptide binding]; other site 1121362006676 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1121362006677 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1121362006678 dimer interface [polypeptide binding]; other site 1121362006679 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121362006680 catalytic residue [active] 1121362006681 serine O-acetyltransferase; Region: cysE; TIGR01172 1121362006682 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1121362006683 trimer interface [polypeptide binding]; other site 1121362006684 active site 1121362006685 substrate binding site [chemical binding]; other site 1121362006686 CoA binding site [chemical binding]; other site 1121362006687 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121362006688 Coenzyme A binding pocket [chemical binding]; other site 1121362006689 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1121362006690 putative homodimer interface [polypeptide binding]; other site 1121362006691 putative homotetramer interface [polypeptide binding]; other site 1121362006692 putative allosteric switch controlling residues; other site 1121362006693 putative metal binding site [ion binding]; other site 1121362006694 putative homodimer-homodimer interface [polypeptide binding]; other site 1121362006695 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1121362006696 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1121362006697 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1121362006698 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1121362006699 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1121362006700 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1121362006701 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1121362006702 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1121362006703 FMN binding site [chemical binding]; other site 1121362006704 active site 1121362006705 catalytic residues [active] 1121362006706 substrate binding site [chemical binding]; other site 1121362006707 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1121362006708 PhoU domain; Region: PhoU; pfam01895 1121362006709 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1121362006710 Cytochrome P450; Region: p450; cl12078 1121362006711 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1121362006712 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1121362006713 Walker A/P-loop; other site 1121362006714 ATP binding site [chemical binding]; other site 1121362006715 Q-loop/lid; other site 1121362006716 ABC transporter signature motif; other site 1121362006717 Walker B; other site 1121362006718 D-loop; other site 1121362006719 H-loop/switch region; other site 1121362006720 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1121362006721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121362006722 dimer interface [polypeptide binding]; other site 1121362006723 conserved gate region; other site 1121362006724 putative PBP binding loops; other site 1121362006725 ABC-ATPase subunit interface; other site 1121362006726 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1121362006727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121362006728 dimer interface [polypeptide binding]; other site 1121362006729 conserved gate region; other site 1121362006730 putative PBP binding loops; other site 1121362006731 ABC-ATPase subunit interface; other site 1121362006732 PBP superfamily domain; Region: PBP_like_2; cl17296 1121362006733 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1121362006734 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121362006735 Coenzyme A binding pocket [chemical binding]; other site 1121362006736 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1121362006737 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1121362006738 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1121362006739 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1121362006740 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1121362006741 heme-binding site [chemical binding]; other site 1121362006742 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1121362006743 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1121362006744 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121362006745 catalytic residue [active] 1121362006746 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1121362006747 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1121362006748 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1121362006749 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1121362006750 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1121362006751 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1121362006752 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1121362006753 dimerization interface [polypeptide binding]; other site 1121362006754 putative ATP binding site [chemical binding]; other site 1121362006755 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1121362006756 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1121362006757 active site 1121362006758 tetramer interface [polypeptide binding]; other site 1121362006759 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121362006760 active site 1121362006761 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1121362006762 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1121362006763 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1121362006764 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1121362006765 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121362006766 putative DNA binding site [nucleotide binding]; other site 1121362006767 putative Zn2+ binding site [ion binding]; other site 1121362006768 AsnC family; Region: AsnC_trans_reg; pfam01037 1121362006769 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1121362006770 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1121362006771 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1121362006772 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1121362006773 dimerization interface [polypeptide binding]; other site 1121362006774 ATP binding site [chemical binding]; other site 1121362006775 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1121362006776 dimerization interface [polypeptide binding]; other site 1121362006777 ATP binding site [chemical binding]; other site 1121362006778 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1121362006779 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1121362006780 putative active site [active] 1121362006781 catalytic triad [active] 1121362006782 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1121362006783 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 1121362006784 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1121362006785 generic binding surface I; other site 1121362006786 generic binding surface II; other site 1121362006787 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 1121362006788 putative active site [active] 1121362006789 putative catalytic site [active] 1121362006790 putative Mg binding site IVb [ion binding]; other site 1121362006791 putative phosphate binding site [ion binding]; other site 1121362006792 putative DNA binding site [nucleotide binding]; other site 1121362006793 putative Mg binding site IVa [ion binding]; other site 1121362006794 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1121362006795 catalytic residues [active] 1121362006796 dimer interface [polypeptide binding]; other site 1121362006797 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 1121362006798 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1121362006799 NAD(P) binding site [chemical binding]; other site 1121362006800 catalytic residues [active] 1121362006801 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 1121362006802 putative active site [active] 1121362006803 putative Zn binding site [ion binding]; other site 1121362006804 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1121362006805 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1121362006806 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1121362006807 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1121362006808 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1121362006809 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1121362006810 ATP binding site [chemical binding]; other site 1121362006811 active site 1121362006812 substrate binding site [chemical binding]; other site 1121362006813 adenylosuccinate lyase; Region: purB; TIGR00928 1121362006814 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1121362006815 tetramer interface [polypeptide binding]; other site 1121362006816 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1121362006817 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1121362006818 active site 1121362006819 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1121362006820 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121362006821 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121362006822 homodimer interface [polypeptide binding]; other site 1121362006823 catalytic residue [active] 1121362006824 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1121362006825 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1121362006826 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1121362006827 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1121362006828 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1121362006829 nucleotide binding site/active site [active] 1121362006830 HIT family signature motif; other site 1121362006831 catalytic residue [active] 1121362006832 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1121362006833 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1121362006834 nucleophilic elbow; other site 1121362006835 catalytic triad; other site 1121362006836 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121362006837 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121362006838 dimerization interface [polypeptide binding]; other site 1121362006839 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121362006840 dimer interface [polypeptide binding]; other site 1121362006841 phosphorylation site [posttranslational modification] 1121362006842 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121362006843 ATP binding site [chemical binding]; other site 1121362006844 Mg2+ binding site [ion binding]; other site 1121362006845 G-X-G motif; other site 1121362006846 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121362006847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121362006848 active site 1121362006849 phosphorylation site [posttranslational modification] 1121362006850 intermolecular recognition site; other site 1121362006851 dimerization interface [polypeptide binding]; other site 1121362006852 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121362006853 DNA binding site [nucleotide binding] 1121362006854 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1121362006855 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1121362006856 DNA binding residues [nucleotide binding] 1121362006857 dimer interface [polypeptide binding]; other site 1121362006858 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1121362006859 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1121362006860 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 1121362006861 dimer interface [polypeptide binding]; other site 1121362006862 active site 1121362006863 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1121362006864 substrate binding site [chemical binding]; other site 1121362006865 catalytic residue [active] 1121362006866 pyruvate dehydrogenase; Provisional; Region: PRK06546 1121362006867 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1121362006868 PYR/PP interface [polypeptide binding]; other site 1121362006869 dimer interface [polypeptide binding]; other site 1121362006870 tetramer interface [polypeptide binding]; other site 1121362006871 TPP binding site [chemical binding]; other site 1121362006872 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1121362006873 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1121362006874 TPP-binding site [chemical binding]; other site 1121362006875 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1121362006876 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362006877 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1121362006878 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 1121362006879 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1121362006880 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1121362006881 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1121362006882 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1121362006883 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1121362006884 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1121362006885 active site 1121362006886 homotetramer interface [polypeptide binding]; other site 1121362006887 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1121362006888 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 1121362006889 TIGR03086 family protein; Region: TIGR03086 1121362006890 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1121362006891 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1121362006892 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1121362006893 DNA binding site [nucleotide binding] 1121362006894 domain linker motif; other site 1121362006895 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 1121362006896 putative dimerization interface [polypeptide binding]; other site 1121362006897 putative ligand binding site [chemical binding]; other site 1121362006898 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1121362006899 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1121362006900 intersubunit interface [polypeptide binding]; other site 1121362006901 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1121362006902 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362006903 Walker A/P-loop; other site 1121362006904 ATP binding site [chemical binding]; other site 1121362006905 Q-loop/lid; other site 1121362006906 ABC transporter signature motif; other site 1121362006907 Walker B; other site 1121362006908 D-loop; other site 1121362006909 H-loop/switch region; other site 1121362006910 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1121362006911 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1121362006912 dimer interface [polypeptide binding]; other site 1121362006913 putative PBP binding regions; other site 1121362006914 ABC-ATPase subunit interface; other site 1121362006915 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1121362006916 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1121362006917 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1121362006918 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1121362006919 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1121362006920 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1121362006921 active site 1121362006922 HIGH motif; other site 1121362006923 nucleotide binding site [chemical binding]; other site 1121362006924 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1121362006925 KMSKS motif; other site 1121362006926 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1121362006927 tRNA binding surface [nucleotide binding]; other site 1121362006928 anticodon binding site; other site 1121362006929 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1121362006930 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1121362006931 active site 1121362006932 trimer interface [polypeptide binding]; other site 1121362006933 allosteric site; other site 1121362006934 active site lid [active] 1121362006935 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1121362006936 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1121362006937 homotrimer interaction site [polypeptide binding]; other site 1121362006938 zinc binding site [ion binding]; other site 1121362006939 CDP-binding sites; other site 1121362006940 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1121362006941 substrate binding site; other site 1121362006942 dimer interface; other site 1121362006943 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1121362006944 DNA repair protein RadA; Provisional; Region: PRK11823 1121362006945 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1121362006946 Walker A motif; other site 1121362006947 ATP binding site [chemical binding]; other site 1121362006948 Walker B motif; other site 1121362006949 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1121362006950 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1121362006951 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1121362006952 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1121362006953 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1121362006954 active site clefts [active] 1121362006955 zinc binding site [ion binding]; other site 1121362006956 dimer interface [polypeptide binding]; other site 1121362006957 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1121362006958 endonuclease III; Region: ENDO3c; smart00478 1121362006959 minor groove reading motif; other site 1121362006960 helix-hairpin-helix signature motif; other site 1121362006961 substrate binding pocket [chemical binding]; other site 1121362006962 active site 1121362006963 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1121362006964 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 1121362006965 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1121362006966 Clp amino terminal domain; Region: Clp_N; pfam02861 1121362006967 Clp amino terminal domain; Region: Clp_N; pfam02861 1121362006968 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121362006969 Walker A motif; other site 1121362006970 ATP binding site [chemical binding]; other site 1121362006971 Walker B motif; other site 1121362006972 arginine finger; other site 1121362006973 UvrB/uvrC motif; Region: UVR; pfam02151 1121362006974 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121362006975 Walker A motif; other site 1121362006976 ATP binding site [chemical binding]; other site 1121362006977 Walker B motif; other site 1121362006978 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1121362006979 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1121362006980 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 1121362006981 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1121362006982 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1121362006983 active site 1121362006984 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1121362006985 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362006986 putative substrate translocation pore; other site 1121362006987 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121362006988 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362006989 putative substrate translocation pore; other site 1121362006990 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1121362006991 FOG: CBS domain [General function prediction only]; Region: COG0517 1121362006992 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1121362006993 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1121362006994 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1121362006995 dimer interface [polypeptide binding]; other site 1121362006996 putative anticodon binding site; other site 1121362006997 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1121362006998 motif 1; other site 1121362006999 dimer interface [polypeptide binding]; other site 1121362007000 active site 1121362007001 motif 2; other site 1121362007002 motif 3; other site 1121362007003 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1121362007004 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 1121362007005 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 1121362007006 Protein of unknown function (DUF456); Region: DUF456; pfam04306 1121362007007 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1121362007008 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1121362007009 heme-binding site [chemical binding]; other site 1121362007010 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1121362007011 FAD binding pocket [chemical binding]; other site 1121362007012 FAD binding motif [chemical binding]; other site 1121362007013 phosphate binding motif [ion binding]; other site 1121362007014 beta-alpha-beta structure motif; other site 1121362007015 NAD binding pocket [chemical binding]; other site 1121362007016 Heme binding pocket [chemical binding]; other site 1121362007017 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 1121362007018 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1121362007019 Carbon starvation protein CstA; Region: CstA; pfam02554 1121362007020 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1121362007021 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1121362007022 DTAP/Switch II; other site 1121362007023 Switch I; other site 1121362007024 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1121362007025 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1121362007026 active site 1121362007027 KMSKS motif; other site 1121362007028 Rossmann-like domain; Region: Rossmann-like; pfam10727 1121362007029 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1121362007030 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1121362007031 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1121362007032 catalytic center binding site [active] 1121362007033 ATP binding site [chemical binding]; other site 1121362007034 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1121362007035 homooctamer interface [polypeptide binding]; other site 1121362007036 active site 1121362007037 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1121362007038 dihydropteroate synthase; Region: DHPS; TIGR01496 1121362007039 substrate binding pocket [chemical binding]; other site 1121362007040 dimer interface [polypeptide binding]; other site 1121362007041 inhibitor binding site; inhibition site 1121362007042 GTP cyclohydrolase I; Provisional; Region: PLN03044 1121362007043 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1121362007044 homodecamer interface [polypeptide binding]; other site 1121362007045 active site 1121362007046 putative catalytic site residues [active] 1121362007047 zinc binding site [ion binding]; other site 1121362007048 GTP-CH-I/GFRP interaction surface; other site 1121362007049 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1121362007050 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121362007051 Walker A motif; other site 1121362007052 ATP binding site [chemical binding]; other site 1121362007053 Walker B motif; other site 1121362007054 arginine finger; other site 1121362007055 Peptidase family M41; Region: Peptidase_M41; pfam01434 1121362007056 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121362007057 active site 1121362007058 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1121362007059 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1121362007060 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1121362007061 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1121362007062 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1121362007063 inorganic pyrophosphatase; Provisional; Region: PRK02230 1121362007064 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1121362007065 dimer interface [polypeptide binding]; other site 1121362007066 substrate binding site [chemical binding]; other site 1121362007067 metal binding sites [ion binding]; metal-binding site 1121362007068 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121362007069 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121362007070 FAD binding domain; Region: FAD_binding_3; pfam01494 1121362007071 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 1121362007072 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1121362007073 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1121362007074 spermidine synthase; Provisional; Region: PRK03612 1121362007075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121362007076 S-adenosylmethionine binding site [chemical binding]; other site 1121362007077 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 1121362007078 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 1121362007079 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1121362007080 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1121362007081 active site residue [active] 1121362007082 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1121362007083 MarR family; Region: MarR; pfam01047 1121362007084 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121362007085 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1121362007086 acyl-activating enzyme (AAE) consensus motif; other site 1121362007087 AMP binding site [chemical binding]; other site 1121362007088 active site 1121362007089 CoA binding site [chemical binding]; other site 1121362007090 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1121362007091 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 1121362007092 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1121362007093 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1121362007094 putative trimer interface [polypeptide binding]; other site 1121362007095 putative CoA binding site [chemical binding]; other site 1121362007096 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1121362007097 active site 1121362007098 catalytic triad [active] 1121362007099 oxyanion hole [active] 1121362007100 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1121362007101 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1121362007102 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1121362007103 ring oligomerisation interface [polypeptide binding]; other site 1121362007104 ATP/Mg binding site [chemical binding]; other site 1121362007105 stacking interactions; other site 1121362007106 hinge regions; other site 1121362007107 hypothetical protein; Provisional; Region: PRK07907 1121362007108 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1121362007109 active site 1121362007110 metal binding site [ion binding]; metal-binding site 1121362007111 dimer interface [polypeptide binding]; other site 1121362007112 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 1121362007113 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1121362007114 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1121362007115 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1121362007116 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 1121362007117 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 1121362007118 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1121362007119 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1121362007120 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948 1121362007121 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12592 1121362007122 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1121362007123 carboxylate-amine ligase; Provisional; Region: PRK13517 1121362007124 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1121362007125 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1121362007126 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1121362007127 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1121362007128 active site 1121362007129 catalytic residues [active] 1121362007130 metal binding site [ion binding]; metal-binding site 1121362007131 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1121362007132 dimer interface [polypeptide binding]; other site 1121362007133 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1121362007134 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1121362007135 putative catalytic site [active] 1121362007136 putative metal binding site [ion binding]; other site 1121362007137 putative phosphate binding site [ion binding]; other site 1121362007138 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1121362007139 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1121362007140 putative active site [active] 1121362007141 catalytic site [active] 1121362007142 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1121362007143 putative active site [active] 1121362007144 catalytic site [active] 1121362007145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362007146 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1121362007147 putative substrate translocation pore; other site 1121362007148 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1121362007149 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1121362007150 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1121362007151 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1121362007152 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1121362007153 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1121362007154 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362007155 Walker A/P-loop; other site 1121362007156 ATP binding site [chemical binding]; other site 1121362007157 Q-loop/lid; other site 1121362007158 ABC transporter signature motif; other site 1121362007159 Walker B; other site 1121362007160 D-loop; other site 1121362007161 H-loop/switch region; other site 1121362007162 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1121362007163 nudix motif; other site 1121362007164 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121362007165 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121362007166 substrate binding pocket [chemical binding]; other site 1121362007167 membrane-bound complex binding site; other site 1121362007168 hinge residues; other site 1121362007169 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1121362007170 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1121362007171 active site 1121362007172 ATP binding site [chemical binding]; other site 1121362007173 substrate binding site [chemical binding]; other site 1121362007174 activation loop (A-loop); other site 1121362007175 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 1121362007176 Active site serine [active] 1121362007177 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1121362007178 propionate/acetate kinase; Provisional; Region: PRK12379 1121362007179 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1121362007180 ferredoxin-NADP+ reductase; Region: PLN02852 1121362007181 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121362007182 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1121362007183 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1121362007184 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1121362007185 ATP-grasp domain; Region: ATP-grasp; pfam02222 1121362007186 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1121362007187 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1121362007188 GDP-binding site [chemical binding]; other site 1121362007189 ACT binding site; other site 1121362007190 IMP binding site; other site 1121362007191 PRC-barrel domain; Region: PRC; pfam05239 1121362007192 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 1121362007193 Predicted membrane protein [Function unknown]; Region: COG4129 1121362007194 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1121362007195 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1121362007196 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 1121362007197 active site 1121362007198 intersubunit interface [polypeptide binding]; other site 1121362007199 zinc binding site [ion binding]; other site 1121362007200 Na+ binding site [ion binding]; other site 1121362007201 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 1121362007202 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1121362007203 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1121362007204 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121362007205 active site 1121362007206 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1121362007207 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1121362007208 active site residue [active] 1121362007209 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1121362007210 active site residue [active] 1121362007211 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1121362007212 H+ Antiporter protein; Region: 2A0121; TIGR00900 1121362007213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362007214 putative substrate translocation pore; other site 1121362007215 Domain of unknown function (DUF4265); Region: DUF4265; pfam14085 1121362007216 glucose-1-phosphate adenylyltransferase; Region: glgC; TIGR02091 1121362007217 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1121362007218 ligand binding site; other site 1121362007219 oligomer interface; other site 1121362007220 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1121362007221 dimer interface [polypeptide binding]; other site 1121362007222 N-terminal domain interface [polypeptide binding]; other site 1121362007223 sulfate 1 binding site; other site 1121362007224 Predicted membrane protein [General function prediction only]; Region: COG4194 1121362007225 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1121362007226 Clp amino terminal domain; Region: Clp_N; pfam02861 1121362007227 Clp amino terminal domain; Region: Clp_N; pfam02861 1121362007228 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121362007229 Walker A motif; other site 1121362007230 ATP binding site [chemical binding]; other site 1121362007231 Walker B motif; other site 1121362007232 arginine finger; other site 1121362007233 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121362007234 Walker A motif; other site 1121362007235 ATP binding site [chemical binding]; other site 1121362007236 Walker B motif; other site 1121362007237 arginine finger; other site 1121362007238 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1121362007239 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1121362007240 FAD binding domain; Region: FAD_binding_4; pfam01565 1121362007241 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1121362007242 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 1121362007243 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1121362007244 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121362007245 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1121362007246 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1121362007247 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 1121362007248 catalytic site [active] 1121362007249 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1121362007250 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1121362007251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121362007252 dimer interface [polypeptide binding]; other site 1121362007253 conserved gate region; other site 1121362007254 putative PBP binding loops; other site 1121362007255 ABC-ATPase subunit interface; other site 1121362007256 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1121362007257 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362007258 Walker A/P-loop; other site 1121362007259 ATP binding site [chemical binding]; other site 1121362007260 Q-loop/lid; other site 1121362007261 ABC transporter signature motif; other site 1121362007262 Walker B; other site 1121362007263 D-loop; other site 1121362007264 H-loop/switch region; other site 1121362007265 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1121362007266 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 1121362007267 FAD binding pocket [chemical binding]; other site 1121362007268 conserved FAD binding motif [chemical binding]; other site 1121362007269 phosphate binding motif [ion binding]; other site 1121362007270 beta-alpha-beta structure motif; other site 1121362007271 NAD binding pocket [chemical binding]; other site 1121362007272 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1121362007273 Peptidase family M23; Region: Peptidase_M23; pfam01551 1121362007274 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1121362007275 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1121362007276 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1121362007277 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121362007278 active site 1121362007279 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1121362007280 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1121362007281 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1121362007282 putative active site [active] 1121362007283 catalytic triad [active] 1121362007284 putative dimer interface [polypeptide binding]; other site 1121362007285 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1121362007286 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1121362007287 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1121362007288 NAD(P) binding site [chemical binding]; other site 1121362007289 catalytic residues [active] 1121362007290 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1121362007291 DNA binding residues [nucleotide binding] 1121362007292 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1121362007293 chaperone protein DnaJ; Provisional; Region: PRK14279 1121362007294 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1121362007295 HSP70 interaction site [polypeptide binding]; other site 1121362007296 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1121362007297 Zn binding sites [ion binding]; other site 1121362007298 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1121362007299 dimer interface [polypeptide binding]; other site 1121362007300 heat shock protein GrpE; Provisional; Region: PRK14140 1121362007301 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1121362007302 dimer interface [polypeptide binding]; other site 1121362007303 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1121362007304 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1121362007305 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1121362007306 nucleotide binding site [chemical binding]; other site 1121362007307 NEF interaction site [polypeptide binding]; other site 1121362007308 SBD interface [polypeptide binding]; other site 1121362007309 Proline dehydrogenase; Region: Pro_dh; cl03282 1121362007310 Delta 1-pyrroline-5-carboxylate dehydrogenase [Energy production and conversion]; Region: COG4230 1121362007311 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1121362007312 NAD(P) binding site [chemical binding]; other site 1121362007313 catalytic residues [active] 1121362007314 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1121362007315 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1121362007316 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1121362007317 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1121362007318 amidohydrolase; Region: amidohydrolases; TIGR01891 1121362007319 metal binding site [ion binding]; metal-binding site 1121362007320 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 1121362007321 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 1121362007322 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1121362007323 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1121362007324 proposed catalytic triad [active] 1121362007325 conserved cys residue [active] 1121362007326 nucleosidase; Provisional; Region: PRK05634 1121362007327 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1121362007328 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1121362007329 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1121362007330 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1121362007331 putative active site [active] 1121362007332 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1121362007333 active site 1121362007334 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 1121362007335 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1121362007336 CysD dimerization site [polypeptide binding]; other site 1121362007337 G1 box; other site 1121362007338 putative GEF interaction site [polypeptide binding]; other site 1121362007339 GTP/Mg2+ binding site [chemical binding]; other site 1121362007340 Switch I region; other site 1121362007341 G2 box; other site 1121362007342 G3 box; other site 1121362007343 Switch II region; other site 1121362007344 G4 box; other site 1121362007345 G5 box; other site 1121362007346 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1121362007347 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 1121362007348 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1121362007349 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1121362007350 Active Sites [active] 1121362007351 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1121362007352 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1121362007353 Active Sites [active] 1121362007354 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1121362007355 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1121362007356 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1121362007357 ferredoxin-NADP+ reductase; Region: PLN02852 1121362007358 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121362007359 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1121362007360 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1121362007361 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121362007362 ATP binding site [chemical binding]; other site 1121362007363 putative Mg++ binding site [ion binding]; other site 1121362007364 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121362007365 nucleotide binding region [chemical binding]; other site 1121362007366 ATP-binding site [chemical binding]; other site 1121362007367 SWIM zinc finger; Region: SWIM; pfam04434 1121362007368 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1121362007369 4Fe-4S binding domain; Region: Fer4; cl02805 1121362007370 Cysteine-rich domain; Region: CCG; pfam02754 1121362007371 Cysteine-rich domain; Region: CCG; pfam02754 1121362007372 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1121362007373 aminotransferase AlaT; Validated; Region: PRK09265 1121362007374 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121362007375 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121362007376 homodimer interface [polypeptide binding]; other site 1121362007377 catalytic residue [active] 1121362007378 AAA domain; Region: AAA_21; pfam13304 1121362007379 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1121362007380 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 1121362007381 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1121362007382 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1121362007383 active site 1121362007384 catalytic site [active] 1121362007385 MarR family; Region: MarR_2; pfam12802 1121362007386 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1121362007387 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121362007388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362007389 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1121362007390 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1121362007391 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1121362007392 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1121362007393 trimer interface [polypeptide binding]; other site 1121362007394 active site 1121362007395 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1121362007396 VanW like protein; Region: VanW; pfam04294 1121362007397 quinate/shikimate dehydrogenase; Provisional; Region: PRK14027 1121362007398 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1121362007399 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1121362007400 shikimate binding site; other site 1121362007401 NAD(P) binding site [chemical binding]; other site 1121362007402 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1121362007403 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1121362007404 active site 1121362007405 trimer interface [polypeptide binding]; other site 1121362007406 dimer interface [polypeptide binding]; other site 1121362007407 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1121362007408 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1121362007409 AP (apurinic/apyrimidinic) site pocket; other site 1121362007410 DNA interaction; other site 1121362007411 Metal-binding active site; metal-binding site 1121362007412 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 1121362007413 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1121362007414 active site 1121362007415 Fe binding site [ion binding]; other site 1121362007416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362007417 metabolite-proton symporter; Region: 2A0106; TIGR00883 1121362007418 putative substrate translocation pore; other site 1121362007419 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1121362007420 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1121362007421 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1121362007422 dimerization interface [polypeptide binding]; other site 1121362007423 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1121362007424 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1121362007425 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1121362007426 Ligand Binding Site [chemical binding]; other site 1121362007427 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 1121362007428 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1121362007429 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1121362007430 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1121362007431 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121362007432 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1121362007433 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121362007434 S-adenosylmethionine binding site [chemical binding]; other site 1121362007435 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1121362007436 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121362007437 active site 1121362007438 phosphorylation site [posttranslational modification] 1121362007439 intermolecular recognition site; other site 1121362007440 dimerization interface [polypeptide binding]; other site 1121362007441 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1121362007442 putative DNA binding site [nucleotide binding]; other site 1121362007443 putative Zn2+ binding site [ion binding]; other site 1121362007444 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1121362007445 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121362007446 putative active site [active] 1121362007447 heme pocket [chemical binding]; other site 1121362007448 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121362007449 ATP binding site [chemical binding]; other site 1121362007450 Mg2+ binding site [ion binding]; other site 1121362007451 G-X-G motif; other site 1121362007452 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1121362007453 Citrate transporter; Region: CitMHS; pfam03600 1121362007454 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1121362007455 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1121362007456 active site 1121362007457 substrate-binding site [chemical binding]; other site 1121362007458 metal-binding site [ion binding] 1121362007459 GTP binding site [chemical binding]; other site 1121362007460 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121362007461 S-adenosylmethionine binding site [chemical binding]; other site 1121362007462 LabA_like proteins; Region: LabA_like; cd06167 1121362007463 putative metal binding site [ion binding]; other site 1121362007464 MMPL family; Region: MMPL; pfam03176 1121362007465 MMPL family; Region: MMPL; pfam03176 1121362007466 Predicted integral membrane protein [Function unknown]; Region: COG0392 1121362007467 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1121362007468 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 1121362007469 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 1121362007470 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1121362007471 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1121362007472 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1121362007473 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1121362007474 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121362007475 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1121362007476 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 1121362007477 putative ADP-binding pocket [chemical binding]; other site 1121362007478 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121362007479 O-Antigen ligase; Region: Wzy_C; pfam04932 1121362007480 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1121362007481 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1121362007482 putative active site [active] 1121362007483 putative metal binding site [ion binding]; other site 1121362007484 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1121362007485 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1121362007486 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121362007487 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 1121362007488 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1121362007489 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 1121362007490 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1121362007491 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1121362007492 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1121362007493 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 1121362007494 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1121362007495 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1121362007496 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1121362007497 active site 1121362007498 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1121362007499 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1121362007500 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1121362007501 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1121362007502 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1121362007503 acyl-activating enzyme (AAE) consensus motif; other site 1121362007504 active site 1121362007505 PE-PPE domain; Region: PE-PPE; pfam08237 1121362007506 Putative esterase; Region: Esterase; pfam00756 1121362007507 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 1121362007508 LGFP repeat; Region: LGFP; pfam08310 1121362007509 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1121362007510 LGFP repeat; Region: LGFP; pfam08310 1121362007511 LGFP repeat; Region: LGFP; pfam08310 1121362007512 Predicted esterase [General function prediction only]; Region: COG0627 1121362007513 S-formylglutathione hydrolase; Region: PLN02442 1121362007514 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1121362007515 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1121362007516 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1121362007517 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1121362007518 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121362007519 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1121362007520 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1121362007521 active site 1121362007522 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1121362007523 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1121362007524 active site 1121362007525 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1121362007526 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1121362007527 active site 1121362007528 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1121362007529 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121362007530 UDP-galactopyranose mutase; Region: GLF; pfam03275 1121362007531 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1121362007532 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1121362007533 amidase catalytic site [active] 1121362007534 Zn binding residues [ion binding]; other site 1121362007535 substrate binding site [chemical binding]; other site 1121362007536 LGFP repeat; Region: LGFP; pfam08310 1121362007537 glycerol kinase; Provisional; Region: glpK; PRK00047 1121362007538 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1121362007539 nucleotide binding site [chemical binding]; other site 1121362007540 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121362007541 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1121362007542 active site 1121362007543 motif I; other site 1121362007544 motif II; other site 1121362007545 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121362007546 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1121362007547 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1121362007548 putative acyl-acceptor binding pocket; other site 1121362007549 seryl-tRNA synthetase; Provisional; Region: PRK05431 1121362007550 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1121362007551 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1121362007552 dimer interface [polypeptide binding]; other site 1121362007553 active site 1121362007554 motif 1; other site 1121362007555 motif 2; other site 1121362007556 motif 3; other site 1121362007557 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1121362007558 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121362007559 DNA-binding site [nucleotide binding]; DNA binding site 1121362007560 UTRA domain; Region: UTRA; pfam07702 1121362007561 Septum formation; Region: Septum_form; pfam13845 1121362007562 Septum formation; Region: Septum_form; pfam13845 1121362007563 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1121362007564 Predicted membrane protein [Function unknown]; Region: COG2323 1121362007565 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1121362007566 catalytic core [active] 1121362007567 prephenate dehydratase; Provisional; Region: PRK11898 1121362007568 Prephenate dehydratase; Region: PDT; pfam00800 1121362007569 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1121362007570 putative L-Phe binding site [chemical binding]; other site 1121362007571 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1121362007572 Amidase; Region: Amidase; cl11426 1121362007573 CAAX protease self-immunity; Region: Abi; pfam02517 1121362007574 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1121362007575 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1121362007576 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1121362007577 putative dimer interface [polypeptide binding]; other site 1121362007578 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1121362007579 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 1121362007580 putative active site [active] 1121362007581 catalytic site [active] 1121362007582 putative metal binding site [ion binding]; other site 1121362007583 pyruvate kinase; Provisional; Region: PRK14725 1121362007584 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 1121362007585 active site 1121362007586 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1121362007587 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1121362007588 dimer interface [polypeptide binding]; other site 1121362007589 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1121362007590 NAD binding site [chemical binding]; other site 1121362007591 substrate binding site [chemical binding]; other site 1121362007592 Predicted membrane protein [Function unknown]; Region: COG4425 1121362007593 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1121362007594 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121362007595 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121362007596 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1121362007597 EamA-like transporter family; Region: EamA; pfam00892 1121362007598 PhoD-like phosphatase; Region: PhoD; pfam09423 1121362007599 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1121362007600 putative active site [active] 1121362007601 putative metal binding site [ion binding]; other site 1121362007602 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1121362007603 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1121362007604 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1121362007605 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1121362007606 motif 2; other site 1121362007607 active site 1121362007608 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1121362007609 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1121362007610 molybdopterin cofactor binding site; other site 1121362007611 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1121362007612 molybdopterin cofactor binding site; other site 1121362007613 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1121362007614 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1121362007615 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1121362007616 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1121362007617 Tubby C 2; Region: Tub_2; cl02043 1121362007618 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1121362007619 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1121362007620 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1121362007621 dimerization interface [polypeptide binding]; other site 1121362007622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362007623 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121362007624 putative substrate translocation pore; other site 1121362007625 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 1121362007626 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1121362007627 Protein of unknown function (DUF1682); Region: DUF1682; pfam07946 1121362007628 Lsr2; Region: Lsr2; pfam11774 1121362007629 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1121362007630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121362007631 active site 1121362007632 phosphorylation site [posttranslational modification] 1121362007633 intermolecular recognition site; other site 1121362007634 dimerization interface [polypeptide binding]; other site 1121362007635 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1121362007636 DNA binding residues [nucleotide binding] 1121362007637 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1121362007638 Histidine kinase; Region: HisKA_3; pfam07730 1121362007639 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121362007640 ATP binding site [chemical binding]; other site 1121362007641 Mg2+ binding site [ion binding]; other site 1121362007642 G-X-G motif; other site 1121362007643 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1121362007644 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121362007645 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121362007646 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1121362007647 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1121362007648 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1121362007649 Ligand Binding Site [chemical binding]; other site 1121362007650 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1121362007651 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1121362007652 active site 1121362007653 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1121362007654 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362007655 Walker A/P-loop; other site 1121362007656 ATP binding site [chemical binding]; other site 1121362007657 Q-loop/lid; other site 1121362007658 ABC transporter signature motif; other site 1121362007659 Walker B; other site 1121362007660 D-loop; other site 1121362007661 H-loop/switch region; other site 1121362007662 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1121362007663 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362007664 Walker A/P-loop; other site 1121362007665 ATP binding site [chemical binding]; other site 1121362007666 Q-loop/lid; other site 1121362007667 ABC transporter signature motif; other site 1121362007668 Walker B; other site 1121362007669 D-loop; other site 1121362007670 H-loop/switch region; other site 1121362007671 Predicted transcriptional regulators [Transcription]; Region: COG1725 1121362007672 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121362007673 DNA-binding site [nucleotide binding]; DNA binding site 1121362007674 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1121362007675 LabA_like proteins; Region: LabA_like; cd06167 1121362007676 putative metal binding site [ion binding]; other site 1121362007677 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1121362007678 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1121362007679 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1121362007680 catalytic residues [active] 1121362007681 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1121362007682 metal-binding site [ion binding] 1121362007683 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1121362007684 metal-binding site [ion binding] 1121362007685 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1121362007686 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1121362007687 metal-binding site [ion binding] 1121362007688 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1121362007689 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1121362007690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362007691 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121362007692 putative substrate translocation pore; other site 1121362007693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362007694 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121362007695 replicative DNA helicase; Provisional; Region: PRK05636 1121362007696 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1121362007697 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1121362007698 Walker A motif; other site 1121362007699 ATP binding site [chemical binding]; other site 1121362007700 Walker B motif; other site 1121362007701 DNA binding loops [nucleotide binding] 1121362007702 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1121362007703 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1121362007704 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1121362007705 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1121362007706 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1121362007707 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1121362007708 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1121362007709 dimer interface [polypeptide binding]; other site 1121362007710 ssDNA binding site [nucleotide binding]; other site 1121362007711 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1121362007712 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1121362007713 cell division protein ZipA; Provisional; Region: PRK03427 1121362007714 Predicted integral membrane protein [Function unknown]; Region: COG5650 1121362007715 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1121362007716 Transglycosylase; Region: Transgly; pfam00912 1121362007717 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1121362007718 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1121362007719 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1121362007720 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1121362007721 MarR family; Region: MarR; pfam01047 1121362007722 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1121362007723 Ligand Binding Site [chemical binding]; other site 1121362007724 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1121362007725 Ligand Binding Site [chemical binding]; other site 1121362007726 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1121362007727 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1121362007728 active site residue [active] 1121362007729 hypothetical protein; Provisional; Region: PRK13663 1121362007730 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 1121362007731 SnoaL-like domain; Region: SnoaL_4; pfam13577 1121362007732 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1121362007733 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362007734 D-galactonate transporter; Region: 2A0114; TIGR00893 1121362007735 putative substrate translocation pore; other site 1121362007736 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1121362007737 Amidase; Region: Amidase; cl11426 1121362007738 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1121362007739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121362007740 active site 1121362007741 phosphorylation site [posttranslational modification] 1121362007742 intermolecular recognition site; other site 1121362007743 dimerization interface [polypeptide binding]; other site 1121362007744 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1121362007745 DNA binding residues [nucleotide binding] 1121362007746 dimerization interface [polypeptide binding]; other site 1121362007747 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1121362007748 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1121362007749 FMN-binding pocket [chemical binding]; other site 1121362007750 flavin binding motif; other site 1121362007751 phosphate binding motif [ion binding]; other site 1121362007752 beta-alpha-beta structure motif; other site 1121362007753 NAD binding pocket [chemical binding]; other site 1121362007754 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1121362007755 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1121362007756 catalytic loop [active] 1121362007757 iron binding site [ion binding]; other site 1121362007758 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121362007759 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1121362007760 NAD(P) binding site [chemical binding]; other site 1121362007761 active site 1121362007762 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1121362007763 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1121362007764 iron-sulfur cluster [ion binding]; other site 1121362007765 [2Fe-2S] cluster binding site [ion binding]; other site 1121362007766 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1121362007767 putative alpha subunit interface [polypeptide binding]; other site 1121362007768 putative active site [active] 1121362007769 putative substrate binding site [chemical binding]; other site 1121362007770 Fe binding site [ion binding]; other site 1121362007771 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1121362007772 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1121362007773 active site 1121362007774 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1121362007775 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1121362007776 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1121362007777 putative active site [active] 1121362007778 heme pocket [chemical binding]; other site 1121362007779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121362007780 ATP binding site [chemical binding]; other site 1121362007781 Mg2+ binding site [ion binding]; other site 1121362007782 G-X-G motif; other site 1121362007783 DctM-like transporters; Region: DctM; pfam06808 1121362007784 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1121362007785 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1121362007786 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1121362007787 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1121362007788 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1121362007789 putative DNA binding site [nucleotide binding]; other site 1121362007790 catalytic residue [active] 1121362007791 putative H2TH interface [polypeptide binding]; other site 1121362007792 putative catalytic residues [active] 1121362007793 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1121362007794 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1121362007795 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 1121362007796 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1121362007797 putative substrate binding site [chemical binding]; other site 1121362007798 putative ATP binding site [chemical binding]; other site 1121362007799 metabolite-proton symporter; Region: 2A0106; TIGR00883 1121362007800 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362007801 putative substrate translocation pore; other site 1121362007802 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121362007803 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1121362007804 acyl-activating enzyme (AAE) consensus motif; other site 1121362007805 AMP binding site [chemical binding]; other site 1121362007806 active site 1121362007807 CoA binding site [chemical binding]; other site 1121362007808 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121362007809 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121362007810 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1121362007811 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1121362007812 CoenzymeA binding site [chemical binding]; other site 1121362007813 subunit interaction site [polypeptide binding]; other site 1121362007814 PHB binding site; other site 1121362007815 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 1121362007816 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 1121362007817 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 1121362007818 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 1121362007819 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1121362007820 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 1121362007821 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1121362007822 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1121362007823 FAD binding pocket [chemical binding]; other site 1121362007824 FAD binding motif [chemical binding]; other site 1121362007825 phosphate binding motif [ion binding]; other site 1121362007826 beta-alpha-beta structure motif; other site 1121362007827 NAD(p) ribose binding residues [chemical binding]; other site 1121362007828 NAD binding pocket [chemical binding]; other site 1121362007829 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1121362007830 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1121362007831 catalytic loop [active] 1121362007832 iron binding site [ion binding]; other site 1121362007833 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1121362007834 enoyl-CoA hydratase; Provisional; Region: PRK06688 1121362007835 substrate binding site [chemical binding]; other site 1121362007836 oxyanion hole (OAH) forming residues; other site 1121362007837 trimer interface [polypeptide binding]; other site 1121362007838 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1121362007839 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1121362007840 dimer interface [polypeptide binding]; other site 1121362007841 active site 1121362007842 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1121362007843 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1121362007844 substrate binding site [chemical binding]; other site 1121362007845 oxyanion hole (OAH) forming residues; other site 1121362007846 trimer interface [polypeptide binding]; other site 1121362007847 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK09260 1121362007848 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1121362007849 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1121362007850 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1121362007851 CoenzymeA binding site [chemical binding]; other site 1121362007852 subunit interaction site [polypeptide binding]; other site 1121362007853 PHB binding site; other site 1121362007854 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 1121362007855 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 1121362007856 substrate binding site [chemical binding]; other site 1121362007857 dimer interface [polypeptide binding]; other site 1121362007858 NADP binding site [chemical binding]; other site 1121362007859 catalytic residues [active] 1121362007860 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1121362007861 active site 2 [active] 1121362007862 active site 1 [active] 1121362007863 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1121362007864 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1121362007865 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1121362007866 Walker A/P-loop; other site 1121362007867 ATP binding site [chemical binding]; other site 1121362007868 Q-loop/lid; other site 1121362007869 ABC transporter signature motif; other site 1121362007870 Walker B; other site 1121362007871 D-loop; other site 1121362007872 H-loop/switch region; other site 1121362007873 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1121362007874 FtsX-like permease family; Region: FtsX; pfam02687 1121362007875 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1121362007876 Histidine kinase; Region: HisKA_3; pfam07730 1121362007877 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121362007878 ATP binding site [chemical binding]; other site 1121362007879 Mg2+ binding site [ion binding]; other site 1121362007880 G-X-G motif; other site 1121362007881 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1121362007882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121362007883 active site 1121362007884 phosphorylation site [posttranslational modification] 1121362007885 intermolecular recognition site; other site 1121362007886 dimerization interface [polypeptide binding]; other site 1121362007887 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1121362007888 DNA binding residues [nucleotide binding] 1121362007889 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1121362007890 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1121362007891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362007892 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121362007893 putative substrate translocation pore; other site 1121362007894 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1121362007895 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1121362007896 N- and C-terminal domain interface [polypeptide binding]; other site 1121362007897 active site 1121362007898 catalytic site [active] 1121362007899 metal binding site [ion binding]; metal-binding site 1121362007900 carbohydrate binding site [chemical binding]; other site 1121362007901 ATP binding site [chemical binding]; other site 1121362007902 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364 1121362007903 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1121362007904 Lipase (class 2); Region: Lipase_2; pfam01674 1121362007905 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1121362007906 Lipase (class 2); Region: Lipase_2; pfam01674 1121362007907 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 1121362007908 VanZ like family; Region: VanZ; cl01971 1121362007909 Predicted membrane protein [Function unknown]; Region: COG2149 1121362007910 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 1121362007911 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1121362007912 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1121362007913 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1121362007914 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1121362007915 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1121362007916 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1121362007917 dimerization interface [polypeptide binding]; other site 1121362007918 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1121362007919 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1121362007920 NADP binding site [chemical binding]; other site 1121362007921 dimer interface [polypeptide binding]; other site 1121362007922 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1121362007923 active site 1121362007924 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1121362007925 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1121362007926 HIGH motif; other site 1121362007927 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1121362007928 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1121362007929 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1121362007930 active site 1121362007931 KMSKS motif; other site 1121362007932 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1121362007933 tRNA binding surface [nucleotide binding]; other site 1121362007934 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1121362007935 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1121362007936 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1121362007937 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1121362007938 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 1121362007939 NAD(P) binding pocket [chemical binding]; other site 1121362007940 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1121362007941 Carbon starvation protein CstA; Region: CstA; pfam02554 1121362007942 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1121362007943 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1121362007944 dimer interface [polypeptide binding]; other site 1121362007945 PYR/PP interface [polypeptide binding]; other site 1121362007946 TPP binding site [chemical binding]; other site 1121362007947 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1121362007948 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1121362007949 TPP-binding site [chemical binding]; other site 1121362007950 dimer interface [polypeptide binding]; other site 1121362007951 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1121362007952 MOSC domain; Region: MOSC; pfam03473 1121362007953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362007954 metabolite-proton symporter; Region: 2A0106; TIGR00883 1121362007955 putative substrate translocation pore; other site 1121362007956 choline dehydrogenase; Validated; Region: PRK02106 1121362007957 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121362007958 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1121362007959 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1121362007960 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1121362007961 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 1121362007962 NAD(P) binding site [chemical binding]; other site 1121362007963 catalytic residues [active] 1121362007964 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 1121362007965 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121362007966 Protein of unknown function (DUF454); Region: DUF454; cl01063 1121362007967 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1121362007968 [2Fe-2S] cluster binding site [ion binding]; other site 1121362007969 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1121362007970 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1121362007971 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1121362007972 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1121362007973 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1121362007974 SdpI/YhfL protein family; Region: SdpI; pfam13630 1121362007975 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1121362007976 anthranilate synthase component I; Provisional; Region: PRK13564 1121362007977 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1121362007978 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1121362007979 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1121362007980 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1121362007981 glutamine binding [chemical binding]; other site 1121362007982 catalytic triad [active] 1121362007983 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1121362007984 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1121362007985 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1121362007986 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1121362007987 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1121362007988 active site 1121362007989 ribulose/triose binding site [chemical binding]; other site 1121362007990 phosphate binding site [ion binding]; other site 1121362007991 substrate (anthranilate) binding pocket [chemical binding]; other site 1121362007992 product (indole) binding pocket [chemical binding]; other site 1121362007993 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1121362007994 active site 1121362007995 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1121362007996 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1121362007997 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121362007998 catalytic residue [active] 1121362007999 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1121362008000 substrate binding site [chemical binding]; other site 1121362008001 active site 1121362008002 catalytic residues [active] 1121362008003 heterodimer interface [polypeptide binding]; other site 1121362008004 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1121362008005 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1121362008006 Walker A/P-loop; other site 1121362008007 ATP binding site [chemical binding]; other site 1121362008008 Q-loop/lid; other site 1121362008009 ABC transporter signature motif; other site 1121362008010 Walker B; other site 1121362008011 D-loop; other site 1121362008012 H-loop/switch region; other site 1121362008013 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1121362008014 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1121362008015 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1121362008016 active site 1121362008017 FMN binding site [chemical binding]; other site 1121362008018 substrate binding site [chemical binding]; other site 1121362008019 homotetramer interface [polypeptide binding]; other site 1121362008020 catalytic residue [active] 1121362008021 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1121362008022 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1121362008023 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1121362008024 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1121362008025 hypothetical protein; Validated; Region: PRK00228 1121362008026 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1121362008027 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1121362008028 active site 1121362008029 NTP binding site [chemical binding]; other site 1121362008030 metal binding triad [ion binding]; metal-binding site 1121362008031 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1121362008032 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121362008033 Zn2+ binding site [ion binding]; other site 1121362008034 Mg2+ binding site [ion binding]; other site 1121362008035 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1121362008036 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1121362008037 active site 1121362008038 Ap6A binding site [chemical binding]; other site 1121362008039 nudix motif; other site 1121362008040 metal binding site [ion binding]; metal-binding site 1121362008041 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1121362008042 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1121362008043 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1121362008044 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121362008045 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121362008046 DNA binding residues [nucleotide binding] 1121362008047 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1121362008048 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121362008049 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121362008050 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1121362008051 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1121362008052 catalytic residues [active] 1121362008053 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1121362008054 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1121362008055 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1121362008056 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1121362008057 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1121362008058 active site 1121362008059 metal binding site [ion binding]; metal-binding site 1121362008060 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1121362008061 ParB-like nuclease domain; Region: ParBc; pfam02195 1121362008062 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1121362008063 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1121362008064 P-loop; other site 1121362008065 Magnesium ion binding site [ion binding]; other site 1121362008066 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1121362008067 Magnesium ion binding site [ion binding]; other site 1121362008068 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1121362008069 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1121362008070 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 1121362008071 Haemolytic domain; Region: Haemolytic; pfam01809 1121362008072 ribonuclease P; Reviewed; Region: rnpA; PRK03459 1121362008073 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1121362008074 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1121362008075 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1121362008076 P-loop; other site 1121362008077 Magnesium ion binding site [ion binding]; other site 1121362008078 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 1121362008079 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1121362008080 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1121362008081 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1121362008082 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1121362008083 Transposase; Region: HTH_Tnp_1; pfam01527 1121362008084 putative transposase OrfB; Reviewed; Region: PHA02517 1121362008085 HTH-like domain; Region: HTH_21; pfam13276 1121362008086 Integrase core domain; Region: rve; pfam00665 1121362008087 Integrase core domain; Region: rve_3; pfam13683 1121362008088 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 1121362008089 L-proline 3-hydroxylase, C-terminal; Region: Pro_3_hydrox_C; pfam05373 1121362008090 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1121362008091 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1121362008092 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1121362008093 dimerization interface [polypeptide binding]; other site 1121362008094 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1121362008095 Transposase; Region: HTH_Tnp_1; pfam01527 1121362008096 putative transposase OrfB; Reviewed; Region: PHA02517 1121362008097 HTH-like domain; Region: HTH_21; pfam13276 1121362008098 Integrase core domain; Region: rve; pfam00665 1121362008099 Integrase core domain; Region: rve_3; pfam13683 1121362008100 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1121362008101 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1121362008102 catalytic residues [active] 1121362008103 catalytic nucleophile [active] 1121362008104 Presynaptic Site I dimer interface [polypeptide binding]; other site 1121362008105 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1121362008106 Synaptic Flat tetramer interface [polypeptide binding]; other site 1121362008107 Synaptic Site I dimer interface [polypeptide binding]; other site 1121362008108 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1121362008109 DNA-binding interface [nucleotide binding]; DNA binding site 1121362008110 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1121362008111 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1121362008112 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1121362008113 DNA-binding interface [nucleotide binding]; DNA binding site 1121362008114 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1121362008115 Domain of unknown function DUF21; Region: DUF21; pfam01595 1121362008116 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1121362008117 Transporter associated domain; Region: CorC_HlyC; pfam03471 1121362008118 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1121362008119 Domain of unknown function DUF21; Region: DUF21; pfam01595 1121362008120 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1121362008121 Domain of unknown function DUF302; Region: DUF302; cl01364 1121362008122 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1121362008123 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1121362008124 Transposase; Region: HTH_Tnp_1; pfam01527 1121362008125 putative transposase OrfB; Reviewed; Region: PHA02517 1121362008126 HTH-like domain; Region: HTH_21; pfam13276 1121362008127 Integrase core domain; Region: rve; pfam00665 1121362008128 Integrase core domain; Region: rve_3; pfam13683 1121362008129 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 1121362008130 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121362008131 HAMP domain; Region: HAMP; pfam00672 1121362008132 dimerization interface [polypeptide binding]; other site 1121362008133 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121362008134 dimer interface [polypeptide binding]; other site 1121362008135 phosphorylation site [posttranslational modification] 1121362008136 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121362008137 ATP binding site [chemical binding]; other site 1121362008138 Mg2+ binding site [ion binding]; other site 1121362008139 G-X-G motif; other site 1121362008140 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121362008141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121362008142 active site 1121362008143 phosphorylation site [posttranslational modification] 1121362008144 intermolecular recognition site; other site 1121362008145 dimerization interface [polypeptide binding]; other site 1121362008146 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121362008147 DNA binding site [nucleotide binding] 1121362008148 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121362008149 dimerization interface [polypeptide binding]; other site 1121362008150 putative DNA binding site [nucleotide binding]; other site 1121362008151 putative Zn2+ binding site [ion binding]; other site 1121362008152 H+ Antiporter protein; Region: 2A0121; TIGR00900 1121362008153 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121362008154 putative substrate translocation pore; other site 1121362008155 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1121362008156 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1121362008157 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1121362008158 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1121362008159 potential frameshift: common BLAST hit: gi|300786621|ref|YP_003766912.1| transposase 1121362008160 Transposase; Region: HTH_Tnp_1; cl17663 1121362008161 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 1121362008162 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1121362008163 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1121362008164 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1121362008165 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121362008166 dimerization interface [polypeptide binding]; other site 1121362008167 putative DNA binding site [nucleotide binding]; other site 1121362008168 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1121362008169 putative Zn2+ binding site [ion binding]; other site 1121362008170 CopC domain; Region: CopC; pfam04234 1121362008171 Copper resistance protein D; Region: CopD; pfam05425 1121362008172 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1121362008173 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1121362008174 Peptidase family M23; Region: Peptidase_M23; pfam01551 1121362008175 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121362008176 dimerization interface [polypeptide binding]; other site 1121362008177 putative DNA binding site [nucleotide binding]; other site 1121362008178 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1121362008179 putative Zn2+ binding site [ion binding]; other site 1121362008180 Thioredoxin; Region: Thioredoxin_4; cl17273 1121362008181 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1121362008182 putative active site [active] 1121362008183 redox center [active] 1121362008184 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1121362008185 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1121362008186 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1121362008187 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1121362008188 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 1121362008189 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362008190 Walker A/P-loop; other site 1121362008191 ATP binding site [chemical binding]; other site 1121362008192 Q-loop/lid; other site 1121362008193 ABC transporter signature motif; other site 1121362008194 Walker B; other site 1121362008195 D-loop; other site 1121362008196 H-loop/switch region; other site 1121362008197 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1121362008198 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121362008199 Walker A/P-loop; other site 1121362008200 ATP binding site [chemical binding]; other site 1121362008201 Q-loop/lid; other site 1121362008202 ABC transporter signature motif; other site 1121362008203 Walker B; other site 1121362008204 D-loop; other site 1121362008205 H-loop/switch region; other site 1121362008206 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1121362008207 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 1121362008208 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1121362008209 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1121362008210 active site 1121362008211 multimer interface [polypeptide binding]; other site 1121362008212 Domain of unknown function (DUF305); Region: DUF305; cl17794 1121362008213 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1121362008214 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1121362008215 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1121362008216 FeoA domain; Region: FeoA; pfam04023 1121362008217 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1121362008218 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 1121362008219 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1121362008220 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722 1121362008221 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1121362008222 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1121362008223 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1121362008224 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1121362008225 putative homodimer interface [polypeptide binding]; other site 1121362008226 putative homotetramer interface [polypeptide binding]; other site 1121362008227 putative allosteric switch controlling residues; other site 1121362008228 putative metal binding site [ion binding]; other site 1121362008229 putative homodimer-homodimer interface [polypeptide binding]; other site 1121362008230 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 1121362008231 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1121362008232 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1121362008233 metal-binding site [ion binding] 1121362008234 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1121362008235 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 1121362008236 metal-binding site [ion binding] 1121362008237 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1121362008238 dimerization interface [polypeptide binding]; other site 1121362008239 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1121362008240 Peptidase family M23; Region: Peptidase_M23; pfam01551 1121362008241 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1121362008242 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1121362008243 putative active site [active] 1121362008244 catalytic triad [active] 1121362008245 putative dimer interface [polypeptide binding]; other site 1121362008246 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1121362008247 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1121362008248 ResB-like family; Region: ResB; pfam05140 1121362008249 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1121362008250 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1121362008251 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1121362008252 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1121362008253 catalytic residues [active] 1121362008254 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1121362008255 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1121362008256 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1121362008257 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1121362008258 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121362008259 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121362008260 active site 1121362008261 phosphorylation site [posttranslational modification] 1121362008262 intermolecular recognition site; other site 1121362008263 dimerization interface [polypeptide binding]; other site 1121362008264 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121362008265 DNA binding site [nucleotide binding] 1121362008266 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121362008267 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121362008268 dimerization interface [polypeptide binding]; other site 1121362008269 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121362008270 dimer interface [polypeptide binding]; other site 1121362008271 phosphorylation site [posttranslational modification] 1121362008272 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121362008273 ATP binding site [chemical binding]; other site 1121362008274 Mg2+ binding site [ion binding]; other site 1121362008275 G-X-G motif; other site 1121362008276 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1121362008277 metal-binding site [ion binding] 1121362008278 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1121362008279 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1121362008280 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121362008281 motif I; other site 1121362008282 motif II; other site 1121362008283 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1121362008284 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1121362008285 putative active site [active] 1121362008286 redox center [active] 1121362008287 TrwC relaxase; Region: TrwC; pfam08751 1121362008288 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 1121362008289 AAA domain; Region: AAA_30; pfam13604 1121362008290 Family description; Region: UvrD_C_2; pfam13538