-- dump date   	20140619_051858
-- class       	Genbank::CDS
-- table       	cds_note
-- id	note
NP_203141.1	replication protein
NP_203142.1	hypothetical 52.6 kDa protein
NP_203143.1	hypothetical 17.1 kDa protein
NP_203144.1	ABC transporter ATP-binding protein
NP_203145.1	hypothetical 26.4 kDa protein
NP_203146.1	hypothetical 10.2 kDa protein
NP_203147.1	hypothetical 10.6 kDa protein
NP_203148.1	hypothetical 29.5 kDa protein
NP_203149.1	hypothetical 9.2 kDa protein
NP_203150.1	hypothetical 10.9 kDa protein; similar to N-terminal region of IS1201 transposase
NP_203151.1	hypothetical 25.2 kDa protein; similar to YpkD from Corynebacterium jeikeium plasmid pK43
NP_203152.1	resolvase
NP_203153.1	IncW-like replication protein
NP_203154.1	type Ib partitioning protein
NP_203155.1	type Ib partitioning protein
YP_249768.1	binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.
YP_249769.1	binds the polymerase to DNA and acts as a sliding clamp
YP_249770.1	Required for DNA replication; binds preferentially to single-stranded, linear DNA
YP_249772.1	negatively supercoils closed circular double-stranded DNA
YP_249778.1	negatively supercoils closed circular double-stranded DNA
YP_249781.1	Region start changed from 20454 to 20427 (-27 bases)
YP_249784.1	Probable NUDIX hydrolase
YP_249792.1	Probable RNA polymerase sigma factor (Sigma- K).,Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity).
YP_249798.1	Para-aminobenzoate synthase  (P- aminobenzoic acid synthase) (PABA synthase).,Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine.
YP_249802.1	integral membrane protein involved in inhibition of the Z-ring formation
YP_249803.1	Para-aminobenzoate synthase glutamine amidotransferase component II (ADC synthase).,Catalyzes the biosynthesis of 4-amino-4- deoxychorismate (ADC) from chorismate and glutamine.
YP_249821.1	responsible for recognizing base lesions in the genome and initiating base excision DNA repair
YP_249822.1	catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine
YP_249832.1	Modulates the activities of several enzymes which are inactive in their acetylated form
YP_249841.1	DNA-3-methyladenine glycosylase (EC 3.2.2.20) (3- methyladenine-DNA glycosidase) (TAG).,Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine from the damaged DNA polymer formed by alkylation lesions (By similarity).
YP_249842.1	24-dienoyl-CoA reductase [NADPH] (EC 1.3.1.34) (24- dienoyl coenzyme A reductase).,Catalyzes the NADP- dependent reduction of 24-dienoyl- CoA to yield trans-2- enoyl-CoA.
YP_249845.1	glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate
YP_249846.1	Threonine efflux protein.,Conducts the efflux of threonine (By similarity)
YP_249852.1	Lysozyme M1 precursor (EC 3.2.1.17) (14-beta-N- acetylmuramidase M1).,This enzyme has both lysozyme (acetylmuramidase) and diacetylmuramidase activities.
YP_249853.1	Probable arabinosyltransferase C (EC 2.4.2.- ).,Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan.
YP_249877.1	Alkaline phosphatase D precursor (EC 3.1.3.1) (APaseD).
YP_249880.1	this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress
YP_249882.1	Superoxide dismutase [Mn] (EC 1.15.1.1).,Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
YP_249883.1	Converts (S)-lactate and NAD(+) to pyruvate and NADH
YP_249889.1	Prephenate dehydratase (EC 4.2.1.51) (PDT).
YP_249893.2	catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_249902.1	catalyzes the formation of decaprenylphosphoryl-5-phosphoribose from phosphoribose diphosphate and decaprenyl phosphate
YP_249919.1	tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine
YP_249921.1	catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using GTP
YP_249924.1	NADH dehydrogenase (EC 1.6.99.3) (Alkyl hydroperoxide reductase).,Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
YP_249927.1	Alpha-acetolactate decarboxylase (EC 4.1.1.5).,Converts acetolactate into acetoin which can be excreted by the cells. This may be a mechanism for controlling the internal pH of cells in the stationary stage.
YP_249930.1	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
YP_249944.1	Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis
YP_249945.1	broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor
YP_249949.1	heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria
YP_249950.1	with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor
YP_249958.1	Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (6-O- methylguanine-DNA methyltransferase) (MGMT) (O-6-methylguanine-DNA- alkyltransferase).,Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated (By similarity).
YP_249970.1	C4-dicarboxylate-binding periplasmic protein precursor.,Binds C4-dicarboxylates; part of the binding- protein- dependent transport system for uptake of C4- dicarboxylates.
YP_249976.1	PTS system glucose-specific IIA component (EIIA- Glc) (Glucose- permease IIA component) (Phosphotransferase enzyme II A component) (EC 2.7.1.69) (EIII-Glc).,This is a component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS) a major carbohydrate active
YP_249979.1	acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine
YP_249980.1	catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein
YP_249981.1	part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor
YP_249983.1	involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate
YP_249986.1	catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate
YP_249992.1	catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis
YP_249995.1	B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE
YP_249996.1	in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF
YP_250000.1	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_250003.1	Inosine-uridine preferring nucleoside hydrolase (EC 3.2.2.1) (IU-nucleoside hydrolase) (IU-NH) (Purine nucleosidase).,Catalyzes the hydrolysis of all of the commonly occurring purine and pyrimidine nucleosides into ribose and the associated base but has a preference for inosine and uridine as substrates.
YP_250004.1	catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine
YP_250009.1	non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis
YP_250012.1	NADPH-ferredoxin reductase (EC 1.18.1.2) (NFR).
YP_250015.1	Phosphoadenosine phosphosulfate reductase (EC 1.8.4.8) (PAPS reductase thioredoxin dependent) (PAdoPS reductase) (3- phosphoadenylylsulfate reductase) (PAPS sulfotransferase).,Reduction of activated sulfate into sulfite.
YP_250016.1	with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP
YP_250017.1	CysN/cysC bifunctional enzyme [Includes: Sulfate adenylyltransferase subunit 1 (EC 2.7.7.4) (Sulfate adenylate transferase) (SAT) (ATP- sulfurylase large subunit); Adenylylsulfate kinase (EC 2.7.1.25) (APS kinase) (ATP adenosine-5-phosphosulfate 3- phosphotransferase)].,APS kinase catalyzes the synthesis of activated sulfate (By similarity).
YP_250018.1	phosphonatase: phosphonoacetaldehyde
YP_250020.1	in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta
YP_250021.1	AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA
YP_250028.1	Cardiolipin synthetase (Cardiolipin synthase) (CL synthase).,Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity).
YP_250031.1	cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+)
YP_250034.1	ATP-dependent carboxylate-amine ligase
YP_250037.1	60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth
YP_250044.1	Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho- hydrolase) (PPase).
YP_250048.1	Cell division protein ftsH homolog,Seems to act as an ATP-dependent zinc metallopeptidase (By similarity).
YP_250049.1	involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer
YP_250050.1	Dihydropteroate synthase 1 (EC 2.5.1.15) (DHPS 1) (Dihydropteroate pyrophosphorylase 1).,DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide (By similarity).
YP_250051.1	Probable dihydroneopterin aldolase (EC 4.1.2.25) (DHNA).,Catalyzes the conversion of 78-dihydroneopterin to 6- hydroxymethyl-78-dihydropterin (By similarity).
YP_250056.1	catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine
YP_250060.1	Galactose-1-phosphate uridylyltransferase (EC 2.7.7.12) (Gal-1-P uridylyltransferase) (UDP-glucose-- hexose-1-phosphate uridylyltransferase).
YP_250061.1	Galactokinase (EC 2.7.1.6) (Galactose kinase).
YP_250062.1	Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5)
YP_250064.1	class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1
YP_250067.1	Multifunctional protein thiED [Includes: Thiamine- phosphate pyrophosphorylase (EC 2.5.1.3) (TMP pyrophosphorylase) (TMP-PPase) (Thiamine-phosphate synthase); Phosphomethylpyrimidine kinase (EC 2.7.4.7) (HMP-phosphate kinase) (HMP-P kinase)].,Catalyzes the phosphorylation of HMP-P to HMP-PP (By similarity).
YP_250068.1	activates fatty acids by binding to coenzyme A
YP_250071.1	Branched-chain amino acid transport system
YP_250073.1	Carbonic anhydrase 1 (EC 4.2.1.1). Reversible hydration of carbon dioxide.
YP_250075.2	Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents
YP_250078.1	4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers
YP_250079.1	catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate
YP_250083.1	cysS3; catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA
YP_250090.1	Heme oxygenase (EC 1.14.99.3).,Allows the bacteria to use the host heme as an iron source. Involved in the oxidation of heme and subsequent release of iron from the heme moiety.
YP_250100.1	Trehalose-phosphatase (EC 3.1.3.12) (Trehalose 6- phosphate phosphatase) (TPP).
YP_250102.1	Alphaalpha-trehalose-phosphate synthase [UDP- forming] (EC 2.4.1.15) (Trehalose-6-phosphate synthase) (UDP-glucose-glucosephosphate glucosyltransferase).
YP_250116.1	catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis
YP_250119.1	Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide
YP_250120.1	catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase
YP_250121.1	Protease II (EC 3.4.21.83) (Oligopeptidase B).,Cleaves peptide bonds on the C-terminal side of lysyl and argininyl residues.
YP_250123.1	With PurL and PurQ catalyzes the conversion of formylglycinamide ribonucleotide, ATP, and glutamine to formylglycinamidine ribonucleotide, ADP, and glutamate in the fourth step of the purine biosynthetic pathway
YP_250124.1	catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis
YP_250125.1	catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis
YP_250128.1	Catalyzes first step of the de novo purine nucleotide biosynthetic pathway
YP_250129.1	catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis
YP_250135.1	catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors
YP_250137.1	BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell
YP_250138.1	catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA
YP_250143.1	catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate
YP_250150.1	ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation
YP_250152.1	Phosphate transport system protein phoU.
YP_250155.1	Succinyl-CoA:coenzyme A transferase,Forms succinyl-CoA from succinate and acetyl-CoA.
YP_250165.1	Serine acetyltransferase (EC 2.3.1.30) (SAT).
YP_250167.1	Cysteine synthase chloroplast precursor (EC 2.5.1.47) (O-acetylserine sulfhydrylase) (O-acetylserine (Thiol)-lyase) (CSase B) (CS-B) (OAS-TL B).
YP_250171.1	adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active
YP_250195.1	Region start changed from 504001 to 504037 (-36 bases)
YP_250199.1	Region start changed from 509554 to 509494 (-60 bases)
YP_250200.1	catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate
YP_250201.1	type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH
YP_250202.1	Probable FK506-binding protein (Peptidyl-prolyl cis- trans isomerase) (PPIase) (EC 5.2.1.8) (Rotamase).,PPIases accelerate the folding of proteins.
YP_250206.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_250216.1	ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived
YP_250218.1	Lipase precursor (Triacylglycerol lipase).
YP_250219.1	CysQ protein homolog.,Could help control the pool of 3-phosphoadenoside 5- phosphosulfate or its use in sulfite synthesis (By similarity).
YP_250224.1	functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family
YP_250228.1	recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1
YP_250229.1	Bifunctional putA protein [Includes: Proline dehydrogenase (EC 1.5.99.8) (Proline oxidase); Delta-1- pyrroline-5-carboxylate dehydrogenase (EC 1.5.1.12) (P5C dehydrogenase)].,Oxidizes proline to glutamate for use as a carbon and nitrogen source and also function as a transcriptional repressor of the put operon.
YP_250230.1	Aminobenzoyl-glutamate transport protein.,Essential for aminobenzoyl-glutamate utilization. May transport aminobenzoyl-glutamate into the cell. Seems also to increase the sensitivity to low levels of aminobenzoyl- glutamate. Sufficient to confer aminobenzoyl-glutamate utilization phenotype.
YP_250233.1	binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation
YP_250243.1	catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate
YP_250249.1	catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers
YP_250250.1	smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif
YP_250251.1	Electron transport system for the ribonucleotide reductase system nrdEF.
YP_250252.1	in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF
YP_250253.1	Catalyzes the rate-limiting step in dNTP synthesis
YP_250254.1	Ferritin like protein 1.,Iron-storage protein (By similarity).
YP_250255.1	B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE
YP_250256.1	Probable cytochrome c oxidase polypeptide I (EC 1.9.3.1) (Cytochrome AA3 subunit 1).,Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).
YP_250258.1	Phosphoserine phosphatase (EC 3.1.3.3) (PSP) (O- phosphoserine phosphohydrolase) (PSPase).
YP_250261.1	Probable RNA polymerase sigma factor (Sigma- W).,Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity).
YP_250267.1	catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate
YP_250268.1	involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA
YP_250271.1	converts L-glutamate to D-glutamate, a component of peptidoglycan
YP_250273.1	RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs
YP_250274.1	HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine
YP_250278.1	Probable peroxiredoxin.
YP_250294.1	3'-5' exoribonuclease specific for small oligoribonuclotides
YP_250311.1	ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence
YP_250316.1	Aminopeptidase N (EC 3.4.11.2) (Lysyl aminopeptidase) (Lys-AP) (Alanine aminopeptidase).,Aminopeptidase with broad substrate specificity to several peptides. Shows strong preference for leucine but cleaves also next to Arg and lysine in peptide-bond-containing substrates.
YP_250318.1	catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity
YP_250320.1	Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer
YP_250321.1	hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates
YP_250322.1	hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates
YP_250323.1	binds and unfolds substrates as part of the ClpXP protease
YP_250324.1	Similarity to  transcriptional regulators (TetR family)
YP_250325.1	catalyzes the oxidation of malate to oxaloacetate
YP_250327.1	valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain
YP_250331.1	catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate
YP_250333.1	Ribonuclease E  (RNase E).,This protein matures 5S rRNA from its precursors from all the rRNA genes. It is the major endoribonuclease participating in mRNA turnover (By similarity).
YP_250335.1	involved in the peptidyltransferase reaction during translation
YP_250339.1	essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication
YP_250340.1	catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis
YP_250342.1	Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway
YP_250344.1	transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria
YP_250346.1	Probable phosphoglycerate mutase gpmB (EC 5.4.2.1) (Phosphoglyceromutase) (PGAM).
YP_250352.1	binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase
YP_250354.1	binds to the ribosome on the universally-conserved alpha-sarcin loop
YP_250365.1	converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA
YP_250371.1	Peptidyl-dipeptidase dcp (EC 3.4.15.5) (Dipeptidyl carboxypeptidase).,Removes dipeptides from the C-termini of N-blocked tripeptides tetrapeptides and larger peptides.
YP_250373.1	4-alpha-glucanotransferase (EC 2.4.1.25)
YP_250376.1	catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III
YP_250377.1	Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
YP_250383.1	Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome
YP_250386.1	involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA
YP_250390.1	Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_250396.1	dGTPase type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate
YP_250402.1	NUDIX hydrolase,mutt: mutator mutT protein
YP_250403.1	P
YP_250407.1	synthesizes RNA primers at the replication forks
YP_250431.1	Region start changed from 786421 to 787018 (-597 bases)
YP_250441.1	E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC
YP_250442.1	Region start changed from 797456 to 797510 (-54 bases)
YP_250454.1	catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate
YP_250456.1	catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme
YP_250462.1	catalyzes the formation of biotin from dethiobiotin and sulfur 2 S-adenosyl-L-methionine
YP_250479.1	P
YP_250485.1	catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group
YP_250486.1	lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein
YP_250487.1	E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains
YP_250489.1	catalyzes the removal of N-terminal amino acids preferably leucine from various peptides
YP_250490.1	catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids
YP_250491.1	Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) (NN:DBI PRT) (N(1)- alpha-phosphoribosyltransferase).,Catalyzes the synthesis of alpha-ribazole-5-phosphate from nicotinate mononucleotide (NAMN) and 56- dimethylbenzimidazole (DMB).
YP_250495.1	catalyzes the formation of acetate from pyruvate
YP_250498.1	Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate
YP_250499.1	Probable cytochrome c oxidase polypeptide III (EC 1.9.3.1) (Cytochrome AA3 subunit 3).
YP_250500.1	Ubiquinol-cytochrome c reductase cytochrome c subunit.
YP_250501.1	Ubiquinol-cytochrome c reductase iron-sulfur subunit (Rieske iron- sulfur protein).,Component of the ubiquinol-cytochrome c reductase complex. The Rieske protein is a high potential 2Fe-2S protein.
YP_250502.1	Ubiquinol-cytochrome c reductase cytochrome b subunit.
YP_250508.1	Glucokinase (EC 2.7.1.2) (Glucose kinase).
YP_250512.1	Phospho-2-dehydro-3-deoxyheptonate aldolase (EC 2.5.1.54) (Phospho-2- keto-3-deoxyheptonate aldolase) (DAHP synthetase) (3-deoxy-D-arabino- heptulosonate 7- phosphate synthase).
YP_250515.1	Phytoene dehydrogenase (EC 1.14.99.-) (Phytoene desaturase).,This enzyme converts phytoene into zeta- carotene via the intermediary of phytofluene by the symmetrical introduction of two double bonds at the C-11 and C-11 positions of phytoene.
YP_250517.1	510-methylenetetrahydrofolate reductase (EC 1.7.99.5).
YP_250521.1	MraZ; UPF0040; crystal structure shows similarity to AbrB
YP_250524.1	Peptidoglycan synthetase ftsI precursor (EC 2.4.1.129).,Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates.
YP_250525.1	UDP-N-acetylmuramoylalanyl-D-glutamate--26- diaminopimelate ligase (EC 6.3.2.13) (UDP-N-acetylmuramyl- tripeptide synthetase) (Meso- diaminopimelate-adding enzyme) (UDP-MurNAc-tripeptide synthetase).,Cell wall formation. Diaminopimelic acid adding enzyme (By similarity).
YP_250526.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase (EC 6.3.2.10) (UDP-MurNAc-pentapeptide synthetase) (D-alanyl-D- alanine-adding enzyme).,Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity).
YP_250527.1	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
YP_250528.1	UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation
YP_250530.1	UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis
YP_250531.1	Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis
YP_250532.1	Cell division protein ftsQ homolog.,This protein may be involved in septum formation (By similarity).
YP_250533.1	GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function
YP_250535.1	H
YP_250540.1	IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin)
YP_250541.1	involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function
YP_250551.1	catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase
YP_250552.1	catalyzes the formation of phosphoenolpyruvate from pyruvate
YP_250553.1	Malto-oligosyltrehalose trehalohydrolase (EC 3.2.1.141) (MTHase) (4- alpha-D-{(1->4)-alpha-D- glucano}trehalose trehalohydrolase) (Maltooligosyl trehalose trehalohydrolase).
YP_250560.1	Glycogen operon protein glgX homolog (EC 3.2.1.-).
YP_250563.1	3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate
YP_250564.1	Probable nicotinate-nucleotide pyrophosphorylase [carboxylating] (EC 2.4.2.19) (Quinolinate phosphoribosyltransferase [decarboxylating]) (QAPRTase).
YP_250566.1	catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer
YP_250567.1	catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis
YP_250568.1	catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis
YP_250570.1	with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide
YP_250571.1	catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide and the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)anthranilate; involved in histidine and tryptophan biosynthesis
YP_250572.1	Inositol-1-monophosphatase (EC 3.1.3.25) (IMPase) (Inositol-1- phosphatase) (I-1-Pase).
YP_250573.1	catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase
YP_250574.1	PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers
YP_250575.1	Anthranilate synthase component I (EC 4.1.3.27).
YP_250577.2	involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water
YP_250578.1	catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate
YP_250579.1	catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis
YP_250580.1	transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein
YP_250581.1	catalyzes the formation of phosphoenolpyruvate from pyruvate
YP_250598.1	has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair
YP_250600.2	in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins
YP_250602.1	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_250603.1	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
YP_250604.1	puhA: photosynthetic reaction center
YP_250605.1	catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis
YP_250607.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion
YP_250612.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
YP_250614.1	Translation initiation factor IF-3.,IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
YP_250616.1	binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit
YP_250619.1	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily
YP_250620.1	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily
YP_250622.1	bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate
YP_250623.1	catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate
YP_250624.1	catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine
YP_250625.1	catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation
YP_250626.1	Region start changed from 1007783 to 1007771 (12 bases)
YP_250627.1	catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming
YP_250628.1	catalyzes the formation of arginine from (N-L-arginino)succinate
YP_250629.1	catalyzes the adenylation of ThiS which is involved in the formation of 5-methyl-4-(beta-hydroxyethyl)thiazole phosphate
YP_250630.1	functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate
YP_250632.1	Bifunctional goxB/thiG protein [Includes: Glycine oxidase (EC 1.5.3.-); Thiazole biosynthesis protein thiG].,Required for the synthesis of the thiazole moiety of thiamine (By similarity).
YP_250634.1	Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate
YP_250635.1	required for the synthesis of the hydromethylpyrimidine moiety of thiamine
YP_250640.1	catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr)
YP_250647.1	catalyzes the phosphorylation of NAD to NADP
YP_250648.1	DNA repair protein recN (Recombination protein N).,May be involved in recombinational repair of damaged DNA (By similarity).
YP_250653.1	CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer
YP_250655.1	Region start changed from 1043320 to 1043491 (-171 bases)
YP_250659.1	Hypothetical pseudouridine synthase (EC 4.2.1.70) (Pseudouridylate synthase) (Uracil hydrolyase).
YP_250660.1	CMK catalyzes the formation of (d)CDP from ATP and (d)CMP; the function of the GTP-binding domain EngA appears to be in synchronizing cellular events by interacting with multiple cellular targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide-binding affinities in the two binding domains
YP_250663.1	catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate
YP_250664.1	catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; involved in growth under gluconeogenic conditions and in glycolytic activity at high ATP concentrations in Corynebacterium; NAD and NADP dependent
YP_250678.1	HTH_fis: Helix-turn-helix domain fis-t
YP_250682.1	regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity
YP_250684.1	SecA2; functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond to SecA2; which is non-essential and seems to play a role in secretion of a subset of proteins
YP_250691.1	H
YP_250694.1	catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate
YP_250698.1	proposed role in polysaccahride synthesis
YP_250733.1	catalyzes the formation of fumarate from aspartate
YP_250734.1	long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors
YP_250738.1	catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA
YP_250739.1	BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell
YP_250741.1	catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors
YP_250751.1	Catalyzes the conversion of citrate to isocitrate
YP_250753.1	ACT domain-containing protein
YP_250757.1	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
YP_250758.1	Catalyzes the transfer of the ammonia group from glutamine to a new carbon-nitrogen group
YP_250762.1	May be involved in the formation or repair of [Fe- S] clusters present in iron-sulfur proteins (Potential).
YP_250773.1	converts protoheme IX and farnesyl diphosphate to heme O
YP_250774.1	catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase
YP_250775.1	catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate
YP_250776.1	catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate
YP_250777.1	OpcA: opcA protein
YP_250778.1	GDH/6PGL endoplasmic bifunctional protein precursor [Includes: Glucose 1-dehydrogenase (EC 1.1.1.47) (Hexose-6- phosphate dehydrogenase); 6- phosphogluconolactonase (EC 3.1.1.31) (6PGL)].,Oxidizes glucose-6-phosphate and glucose as well as other hexose-6-phosphates.
YP_250779.1	Protein-export membrane protein SecG.,Involved in protein export. Participates in an early event of protein translocation (By similarity).
YP_250780.1	catalyzes the formation of oxaloacetate from phosphoenolpyruvate
YP_250781.1	tpi; Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate
YP_250782.1	Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway
YP_250787.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
YP_250789.1	RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not
YP_250790.1	bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate
YP_250791.1	catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine
YP_250792.1	Riboflavin biosynthesis protein ribD [Includes: Diaminohydroxyphosphoribosylaminopyrimidine deaminase (EC 3.5.4.26) (Riboflavin-specific deaminase); 5-amino-6-(5- phosphoribosylamino)uracil reductase (EC 1.1.1.193) (HTP reductase)].,Converts 25-diamino-6-(ribosylamino)-4(3h)- pyrimidinone 5-phosphate into 5-amino-6-(ribosylamino)- 24(1h3h)- pyrimidinedione 5-phosphate.,InterPro: Riboflavin biosynthesis protein RibD,eubact_ribD: riboflavin biosynthesis
YP_250793.1	Ribulose-phosphate 3-epimerase (EC 5.1.3.1) (Pentose-5-phosphate 3- epimerase) (PPE) (R5P3E).
YP_250795.1	Methionyl-tRNA formyltransferase (EC 2.1.2.9).,Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N- formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity).
YP_250796.1	cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+)
YP_250797.1	binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity
YP_250798.1	catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase
YP_250799.1	catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine
YP_250800.1	Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
YP_250801.1	Essential for recycling GMP and indirectly, cGMP
YP_250803.1	type 2 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase
YP_250804.1	four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity
YP_250805.1	catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers
YP_250806.1	catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis
YP_250807.1	catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis
YP_250808.1	regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity
YP_250809.1	Regulates rRNA biosynthesis by transcriptional antitermination
YP_250810.1	Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA
YP_250812.1	catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis
YP_250813.1	catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis
YP_250814.1	catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis
YP_250815.2	catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis
YP_250817.1	Shikimate 5-dehydrogenase (EC 1.1.1.25).
YP_250819.1	similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function
YP_250820.1	Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_250823.1	catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes
YP_250827.1	catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG
YP_250831.1	catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis
YP_250833.1	forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF
YP_250834.1	part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane
YP_250836.1	promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration
YP_250837.1	plays an essential role in ATP-dependent branch migration of the Holliday junction
YP_250838.1	endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity
YP_250842.1	with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate
YP_250845.1	Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA
YP_250846.1	Hypothetical protein PH0460.,InterPro: CDP-alcohol phosphatidyltransferase,pgsA: CDP-diacylglycerol--glycerol- 3-p
YP_250848.1	catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr)
YP_250856.1	Protoporphyrinogen oxidase (EC 1.3.3.4) (PPO).,Catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Also oxidizes the pathway intermediate coproporphyrinogen III.
YP_250857.1	catalyzes the formation of coproporphyrinogen from uroporphyrinogen III
YP_250859.1	Ribonuclease D (EC 3.1.26.3) (RNase D).,Cleaves multimeric tRNA precursor at the spacer region (By similarity).
YP_250860.1	catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate
YP_250862.1	P
YP_250864.1	catalyzes the formation of dUMP from dUTP
YP_250867.1	Inositol-1(or 4)-monophosphatase 1 (EC 3.1.3.25) (IMPase 1) (IMP 1) (Inositol monophosphatase 1).,Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides.
YP_250868.1	Polyphosphate glucokinase (EC 2.7.1.63) (Polyphosphate-glucose phosphotransferase).,Catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor.
YP_250869.1	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
YP_250875.1	hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine
YP_250876.1	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma factors in this cluster are active during stationary phase
YP_250884.1	Probable hydrogen peroxide-inducible genes activator.,Involved in the response to hydrogen peroxide (By similarity).
YP_250888.1	Represses a number of genes involved in the response to DNA damage
YP_250892.1	involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate
YP_250893.1	IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity
YP_250896.1	catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A)
YP_250897.1	binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities
YP_250898.1	catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs
YP_250911.1	catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis
YP_250912.1	flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor
YP_250913.1	catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis
YP_250917.1	primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence
YP_250918.1	catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities
YP_250919.1	catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs
YP_250920.1	Probable 4-phosphopantetheinyl transferase entD (EC 2.7.8.-) (Enterobactin synthetase component D) (Enterochelin synthase D).
YP_250923.1	associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock
YP_250924.1	Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
YP_250926.1	modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination
YP_250927.1	in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins
YP_250929.1	catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro)
YP_250933.1	malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate
YP_250935.1	catalyzes the reduction of mycothione or glutathione to mycothione or glutathione disulfide
YP_250941.1	catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mnin Bacillus subtilis the protein in this cluster is considered non-essential
YP_250947.1	catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis
YP_250949.1	catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate
YP_250951.1	23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance
YP_250954.1	Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs
YP_250955.1	Catalyzes the phosphorylation of UMP to UDP
YP_250956.1	EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu
YP_250957.1	one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit
YP_250959.1	Tyrosine recombinase xerC.,Site-specific tyrosine recombinase which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The xerC-xerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity).
YP_250964.1	RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids
YP_250965.1	Region start changed from 1382599 to 1382581 (-18 bases)
YP_250966.1	this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
YP_250968.1	High-affinity choline transport protein.,High- affinity uptake of choline driven by a proton- motive force.
YP_250969.1	Betaine aldehyde dehydrogenase (EC 1.2.1.8) (BADH).,This is a soluble NAD-dependent betaine aldehyde- specific dehydrogenase. Essential for the utilization of choline as a precursor.
YP_250970.1	High-affinity choline transport protein.,High- affinity uptake of choline driven by a proton- motive force.
YP_250971.1	catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine
YP_250972.1	methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA
YP_250973.1	Essential for efficient processing of 16S rRNA
YP_250974.1	converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer
YP_250975.1	binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity
YP_250977.1	Signal recognition particle protein.,Necessary for efficient export of extra-cytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes (By similarity).
YP_250978.1	Nitrogen regulatory protein P-II.,P-II indirectly controls the transcription of the glutamine synthetase gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate the transcriptional activator of glnA. When P-II is uridylylated to P-II-UMP these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases P-II is uridylylated to P-II-UMP which causes the deadenylylation of glutamine synthetase by glnE so activating the enzyme (By similarity).
YP_250979.1	Ammonium transporter.,Involved in the uptake of ammonia.
YP_250982.1	catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_250987.1	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases
YP_250988.1	cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity
YP_250991.1	Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA
YP_250996.1	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
YP_250997.1	catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP
YP_250999.1	D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli
YP_251000.1	gpsA1; catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate
YP_251002.2	catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D
YP_251003.1	dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate
YP_251022.1	Mrr restriction system protein (EcoKMrr).,Involved in the acceptance of foreign DNA which is modified. Restricts both adenine- and cytosine-methylated DNA.
YP_251025.1	Probable dipeptidase pepE (EC 3.4.13.-).
YP_251053.1	Glycogen phosphorylase (EC 2.4.1.1).,Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However all known phosphorylases share catalytic and structural properties (By similarity).
YP_251055.1	catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions
YP_251056.1	Potassium-transporting ATPase B chain (EC 3.6.3.12) (Potassium- translocating ATPase B chain) (ATP phosphohydrolase [potassium- transporting] B chain) (Potassium binding and translocating subunit B).,One of the components of the high-affinity ATP-driven potassium transport (or KDP) system which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity).
YP_251057.1	Potassium-transporting ATPase C chain (EC 3.6.3.12) (Potassium- translocating ATPase C chain) (ATP phosphohydrolase [potassium- transporting] C chain) (Potassium binding and translocating subunit C).,One of the components of the high-affinity ATP-driven potassium transport (or KDP) system which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity).
YP_251058.1	Sensor protein KdpD (EC 2.7.3.-).,Member of the two- component regulatory system KdpD/KdpE involved in the regulation of the kdp operon. KdpD may function as a membrane-associated protein kinase that phosphorylates KdpE in response to environmental signals.
YP_251059.1	Kdp operon transcriptional regulatory protein KdpE.,Member of the two-component regulatory system KdpD/KdpE involved in the regulation of the kdp operon.
YP_251068.1	Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation
YP_251072.1	Isochorismate synthase dhbC (EC 5.4.4.2) (Isochorismate mutase).
YP_251075.1	catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis
YP_251078.1	catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate
YP_251086.1	catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis
YP_251087.1	with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit
YP_251088.1	acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate
YP_251092.1	catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis
YP_251095.1	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA
YP_251097.1	catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis
YP_251101.1	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA
YP_251103.1	threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway
YP_251105.1	3'-5' exonuclease of DNA polymerase III
YP_251107.1	this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB
YP_251110.1	catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs
YP_251120.1	catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain
YP_251124.1	part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane
YP_251125.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit
YP_251126.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit
YP_251127.1	produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit
YP_251128.1	produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex
YP_251129.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.
YP_251130.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0
YP_251131.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0
YP_251136.1	recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2
YP_251137.1	An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes
YP_251138.1	activates fatty acids by binding to coenzyme A
YP_251140.1	catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate
YP_251141.1	catalyzes the formation of L-threonine from O-phospho-L-homoserine
YP_251142.1	catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine
YP_251143.1	Diaminopimelate decarboxylase (EC 4.1.1.20) (DAP decarboxylase).
YP_251144.1	catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase
YP_251151.1	I
YP_251153.1	Osmoregulated proline transporter (Sodium/proline symporter).,Catalyzes the sodium-dependent uptake of extracellular proline.
YP_251164.1	kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth
YP_251171.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein is involved in heat shock, oxidative stress and virulence
YP_251172.1	fucA: L-fuculose phosphate aldolase
YP_251174.2	catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate
YP_251177.1	Mycinamicin-resistance protein.,Confers strong resistance to mycinamicin (MM) and tylosin (TY).
YP_251178.1	Probable cytosol aminopeptidase (EC 3.4.11.1) (Leucine aminopeptidase) (LAP) (Leucyl aminopeptidase).,Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity).
YP_251181.1	catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate
YP_251183.1	Probable 2345-tetrahydropyridine-26-dicarboxylate N- succinyltransferase (EC 2.3.1.117) (Tetrahydrodipicolinate N-succinyltransferase) (THP succinyltransferase) (Tetrahydropicolinate succinylase).
YP_251185.1	catalyzes the formation of N-succinyl-LL-2,6-diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis
YP_251195.1	Chloramphenicol resistance protein Cmx
YP_251220.1	Probable copper exporting ATPase B (EC 3.6.3.4).,The copper transporting proteins CopA and CopB are implicated in the regulation of cytoplasmic copper CopA being the importer and CopB the exporter of the metal. They may probably serve as well for the import of other metals.
YP_251235.1	translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1
YP_251240.1	catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway
YP_251241.1	bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides
YP_251242.1	catalyzes the bidirectional exonucleolytic cleavage of DNA
YP_251244.1	type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese
YP_251245.1	fum; class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle
YP_251255.1	Pyrazinamidase/nicotinamidase (EC 3.5.1.-) (EC 3.5.1.19) (PZAase) (Nicotine deamidase) (NAMase).
YP_251256.1	catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate
YP_251257.1	catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis
YP_251262.1	necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YP_251264.1	NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate
YP_251267.1	H
YP_251271.1	Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate of circa 500 residues long while chains of circa 15 residues compete poorly with polyphosphate as substrate.
YP_251274.1	enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis
YP_251281.1	Transcription-repair coupling factor (TRCF).,Necessary for strand-specific repair. A lesion in the template strand blocks the RNA polymerase complex (RNAP). The RNAP-DNA-RNA complex is specifically recognized by TRCF which releases RNAP and the truncated transcript; the TCRF may replace RNAP at the lesion site and then recruit the uvrA/B/C repair system (By similarity).
YP_251283.1	forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis
YP_251284.1	catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP
YP_251285.1	the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response
YP_251286.1	Enables the recycling of peptidyl-tRNAs produced at termination of translation
YP_251287.1	Enables the recycling of peptidyl-tRNAs produced at termination of translation
YP_251289.1	Peptide chain release factor 3 (RF-3).,Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP but not by GMP (By similarity).
YP_251294.1	catalyzes the formation of 3-hydroxy-2-methylpropanoate from 3-hydroxy-2-methylpropanoyl-CoA
YP_251301.1	catalyzes the phosphorylation of 4-diphosphocytidyl-2-C-methyl-D-erythritol in the nonmevalonate pathway of isoprenoid biosynthesis
YP_251302.1	catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin
YP_251304.1	TatD-related deoxyribonuclease
YP_251307.1	methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content
YP_251308.1	Glycine betaine transporter betP.,High-affinity uptake of glycine betaine (By similarity).
YP_251314.1	Ribosomal-protein-alanine acetyltransferase (EC 2.3.1.128) (Acetylating enzyme for N-terminal of ribosomal protein S5).,This enzyme acetylates the N-terminal alanine of ribosomal protein S5.
YP_251318.1	Large-conductance mechanosensitive channel.,Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
YP_251324.1	some L32 proteins have zinc finger motifs consisting of CXXC while others do not
YP_251325.1	RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome
YP_251326.1	required for 70S ribosome assembly
YP_251327.1	in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif
YP_251328.1	located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif
YP_251329.1	binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit
YP_251334.1	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis
YP_251337.1	activates fatty acids by binding to coenzyme A
YP_251338.1	Citrate lyase beta chain (EC 4.1.3.6),Represents a citryl-ACP lyase (By similarity)
YP_251347.1	involved in de novo purine biosynthesis
YP_251348.1	glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate
YP_251354.1	activates fatty acids by binding to coenzyme A
YP_251361.1	Probable protease htpX homolog (EC 3.4.24.-).
YP_251367.1	Region start changed from 1847170 to 1847728 (-558 bases)
YP_251372.1	Region start changed from 1854098 to 1854635 (-537 bases)
YP_251389.1	together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z
YP_251401.1	Probable DNA helicase II homolog (EC 3.6.1.-).,Has both ATPase and helicase activities. Unwinds DNA duplexes with 3 to 5 polarity with respect to the bound strand and initiates unwinding most effectively when a single- stranded region is present. Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair (By similarity).
YP_251404.1	Probable DNA helicase II homolog (EC 3.6.1.-).,Has both ATPase and helicase activities. Unwinds DNA duplexes with 3 to 5 polarity with respect to the bound strand and initiates unwinding most effectively when a single- stranded region is present. Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair (By similarity).
YP_251408.1	ATP-dependent RNA helicase rhlB (EC 3.6.1.-).,Can carry out ATP-dependent unwinding of double stranded RNA. Has a role in RNA decay. Involved in the RNA degradosome a multi-enzyme complex important in RNA processing and messenger RNA degradation (By similarity).
YP_251415.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response
YP_251417.1	catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis
YP_251422.1	functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins
YP_251429.1	catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP)
YP_251430.1	catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine
YP_251433.1	Mannose-6-phosphate isomerase (EC 5.3.1.8) (Phosphomannose isomerase) (PMI) (Phosphohexomutase).,Involved in the conversion of glucose to GDP-L-fucose which can be converted to L-fucose a capsular polysaccharide.
YP_251434.1	pmmA; converts mannose-6-phosphate to mannose-1-phosphate; the resulting product is then converted to GDP-mannose by ManC which is then used in the synthesis of mannose-containing glycoconjugates that are important for mediating entry into host cells
YP_251453.1	Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC).
YP_251454.1	With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway
YP_251456.1	BirA bifunctional protein [Includes: Biotin operon repressor; Biotin--[acetyl-CoA-carboxylase] synthetase (EC 6.3.4.15) (Biotin--protein ligase)].,BirA acts both as a biotin-operon repressor and as the enzyme that synthesizes the corepressor acetyl-CoA:carbon- dioxide ligase. This protein also activates biotin to form biotinyl-5-adenylate and transfers the biotin moiety to biotin-accepting proteins (By similarity).
YP_251459.1	Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell
YP_251460.1	catalyzes the formation of citrate from acetyl-CoA and oxaloacetate
YP_251466.1	Glycerol kinase 2 (EC 2.7.1.30) (ATP:glycerol 3- phosphotransferase 2) (Glycerokinase 2) (GK 2).,Key enzyme in the regulation of glycerol uptake and metabolism.
YP_251469.1	catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation
YP_251471.1	Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate
YP_251482.1	catalyzes the formation of inosine from adenosine
YP_251484.1	catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_251488.1	Isocitrate dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate decarboxylase) (IDH).
YP_251489.1	catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol
YP_251490.1	Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine
YP_251492.1	catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate
YP_251504.1	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis. It is not the major replicative DNA polymerase.
YP_251511.1	DNA polymerase IV 1 (EC 2.7.7.7) (Pol IV 1).,Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity).
YP_251515.1	contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway
YP_251517.1	catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate
YP_251518.1	catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate
YP_251521.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this protein is involved in expression of ribosome-associated gene products in stationary phase
YP_251523.1	60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is not essential for growth
YP_251524.1	10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring
YP_251529.1	Alanine racemase (EC 5.1.1.1).,Provides the D- alanine required for cell wall biosynthesis (By similarity).
YP_251530.1	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
YP_251538.1	pmmC; catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
YP_251539.1	forms a direct contact with the tRNA during translation
YP_251540.2	in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit
YP_251549.1	6
YP_251550.1	mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability
YP_251552.1	is a component of the macrolide binding site in the peptidyl transferase center
YP_251553.1	catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme
YP_251554.1	primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination
YP_251555.1	located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3
YP_251556.1	located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA
YP_251557.1	stimulates the activities of the other two initiation factors, IF-2 and IF-3
YP_251559.1	catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn
YP_251560.1	essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP
YP_251561.1	forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase
YP_251573.1	Enterochelin esterase (Ferric enterobactin esterase).,Upon internalization ferric enterobactin is processed via an exquisitely specific pathway that is dependent on FES activity making iron available for metabolic use.
YP_251575.1	L-ornithine 5-monooxygenase (EC 1.13.12.-) (L- ornithine N5-oxygenase).,Catalyzes the hydroxylation of L- ornithine (L-Orn) which is later incorporated in pyoverdin. Pyoverdin is a hydroxamate siderophore composed of a 67-dihydroxyquinoline-containing fluorescent chromophore joined to the N-terminus of a partly cyclic octapeptide (D-Ser-L-Arg-D-Ser-L-N5-OH-Orn-L-Lys-L-N5-OH- Orn-L-Thr-L-Thr in strain PAO1).
YP_251586.1	Region start changed from 2091155 to 2091221 (-66 bases)
YP_251587.1	late assembly protein
YP_251588.1	L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7
YP_251589.1	located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance
YP_251590.1	binds 5S rRNA along with protein L5 and L25
YP_251591.1	ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance
YP_251592.1	binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
YP_251594.1	part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13
YP_251595.1	assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel
YP_251596.1	binds to the 23S rRNA between the centers for peptidyl transferase and GTPase
YP_251615.1	23-dihydroxybenzoate-AMP ligase (EC 6.3.2.-) (Dihydroxybenzoic acid- activating enzyme).,Activation of the carboxylate group of 23-dihydroxy- benzoate (DHB) via ATP-dependent PPi exchange reactions to the acyladenylate.
YP_251619.1	primary binding protein; helps mediate assembly; involved in translation fidelity
YP_251620.1	one of the stabilizing components for the large ribosomal subunit
YP_251621.1	located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e
YP_251622.1	forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation
YP_251623.1	binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center
YP_251624.1	protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
YP_251625.1	one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation
YP_251626.1	binds third domain of 23S rRNA and protein L29; part of exit tunnel
YP_251627.1	L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA
YP_251628.1	binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin
YP_251629.1	NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex
YP_251634.1	EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu
YP_251635.1	EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene
YP_251637.1	binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit
YP_251638.2	interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance
YP_251642.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter
YP_251643.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme
YP_251645.1	present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors
YP_251646.1	binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit
YP_251657.1	in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA
YP_251658.1	binds directly to 23S ribosomal RNA
YP_251659.1	Modulates Rho-dependent transcription termination
YP_251660.1	forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force
YP_251663.2	Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone
YP_251666.1	SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis
YP_251667.1	catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate
YP_251668.1	catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA
YP_251675.1	O-succinylbenzoate--CoA ligase (EC 6.2.1.26) (OSB- CoA synthetase) (O- succinylbenzoyl-CoA synthetase).,Converts O-succinylbenzoate (OSB) to O- succinylbenzoyl- CoA (OSB-CoA).
YP_251676.1	catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate
YP_251677.1	Region start changed from 2193370 to 2193262 (-108 bases)
YP_251682.1	dTDP-4-dehydrorhamnose 35-epimerase (EC 5.1.3.13) (dTDP-4-keto-6- deoxyglucose 35-epimerase) (dTDP-L- rhamnose synthetase).
YP_251691.1	Cytochrome c-type biogenesis protein ccdA.,Required for cytochrome c synthesis and stage V of sporulation. Might transfer reducing equivalents across the cytoplasmic membrane promoting efficient disulfide bond isomerization of proteins localized on the outer surface of the membrane or in the spore coat (By similarity).
YP_251693.1	Probable phosphoglycerate mutase gpmB (EC 5.4.2.1) (Phosphoglyceromutase) (PGAM).
YP_251694.1	Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway
YP_251698.1	catalyzes the formation of porphobilinogen from 5-aminolevulinate
YP_251699.1	Porphyrin biosynthesis protein HEMD [Includes: Uroporphyrin-III C- methyltransferase (EC 2.1.1.107) (Urogen III methylase) (SUMT) (Uroporphyrinogen III methylase) (UROM); Uroporphyrinogen-III synthase (EC 4.2.1.75) (UROS) (Uroporphyrinogen-III cosynthetase) (Hydroxymethylbilane hydrolyase [cyclizing])].,May catalyze sequential reactions to synthesize UroIII from hydroxymethylbilane (HMB) and then precorrin-2 which are intermediate compounds in both vitamin B12 and siroheme biosyntheses.
YP_251700.1	Porphobilinogen deaminase (EC 2.5.1.61) (PBG) (Hydroxymethylbilane synthase) (HMBS) (Pre- uroporphyrinogen synthase).,Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane preuroporphyrinogen in several discrete steps.
YP_251701.1	catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins
YP_251705.1	catalyzes the formation of L-proline from pyrroline-5-carboxylate
YP_251707.1	Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate of circa 500 residues long while chains of circa 15 residues compete poorly with polyphosphate as substrate.
YP_251714.1	activates fatty acids by binding to coenzyme A
YP_251715.1	Alkane-1 monooxygenase (EC 1.14.15.3) (Alkane omega- hydroxylase).,Is responsible for the initial oxidation of inactivated alkanes.
YP_251717.1	InterPro: Rubredoxin-type Fe(Cys)4 protein
YP_251718.1	catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis
YP_251722.1	catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate
YP_251727.1	part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol
YP_251731.1	catalyzes the formation of malate from glyoxylate and acetyl-CoA
YP_251735.1	E3 component of alpha keto acid dehydrogenase complexes LpdC; forms a homodimer; binds one molecule of FAD monomer; catalyzes NAD+-dependent oxidation of dihydrolipoyl cofactors that are covalently linked to the E2 component
YP_251740.1	Oxidizes the CoA-esters of 2-methyl-branched fatty acids (By similarity).
YP_251746.1	Probable 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (EC 2.3.1.51) (1- AGP acyltransferase 1) (1-AGPAT 1) (Lysophosphatidic acid acyltransferase-alpha) (LPAAT-alpha) (1-acylglycerol-3- phosphate O- acyltransferase 1) (G15 protein).
YP_251750.1	catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA
YP_251752.1	Alpha-methylacyl-CoA racemase (EC 5.1.99.4) (2- methylacyl-CoA racemase).,Racemization of 2-methyl- branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers.
YP_251753.1	catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity
YP_251773.1	InterPro: Beta-lactamase-like
YP_251786.1	subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali
YP_251787.1	subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali
YP_251788.1	subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone
YP_251790.1	subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali
YP_251791.1	subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport
YP_251794.1	Catalase (EC 1.11.1.6).,Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.
YP_251795.1	Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription
YP_251796.1	protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic
YP_251797.1	catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde
YP_251798.1	catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation.
YP_251804.1	Arsenate reductase (EC 1.20.4.1) (Arsenical pump modifier).,Reduction of arsenate [As(V)] to arsenite [As(III)].
YP_251810.1	involved in a recombinational process of DNA repair, independent of the recBC complex
YP_251812.1	catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA
YP_251817.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_251818.1	this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu
YP_251820.1	Queuine tRNA-ribosyltransferase (EC 2.4.2.29) (tRNA- guanine transglycosylase) (Guanine insertion enzyme).,Exchanges the guanine residue with 7-aminomethyl- 7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp - Asn -His and -Tyr). After this exchange a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7- deazaguanine resulting in the hypermodified nucleoside queuosine (Q) (7-(((45-cis- dihydroxy-2-cyclopenten-1- yl)amino)methyl)-7-deazaguanosine) (By similarity).
YP_251825.1	catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate
YP_251833.1	Quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase).
YP_251835.1	Probable cysteine desulfurase (EC 2.8.1.7).,Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine L-cystine L-selenocysteine and L- selenocystine to produce L-alanine (By similarity).,am_tr_V_VC1184: cysteine desulfurase
YP_251842.1	activates fatty acids by binding to coenzyme A
YP_251856.1	Thioredoxin.,Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol- disulfide exchange reactions.
YP_251862.1	unwinds double stranded DNA
YP_251864.1	in Escherichia coli this protein is wrapped around the base of the L1 stalk
YP_251865.1	binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA
YP_251866.1	binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21
YP_251875.1	leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase
YP_251877.1	Ribokinase (EC 2.7.1.15).
YP_251878.1	Inosine-uridine preferring nucleoside hydrolase (EC 3.2.2.1) (IU-nucleoside hydrolase) (IU-NH) (Purine nucleosidase).,Catalyzes the hydrolysis of all of the commonly occurring purine and pyrimidine nucleosides into ribose and the associated base but has a preference for inosine and uridine as substrates.
YP_251884.1	mutt: mutator mutT protein
YP_251886.1	Branched-chain amino acid transport protein azlC.,Involved in branched-chain amino acid transport.
YP_251892.1	Probable RNA polymerase sigma factor (Sigma- M).,Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity).
YP_251893.1	Thioredoxin reductase (EC 1.8.1.9) (TRXR) (TR).
YP_251894.1	Thioredoxin.,Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol- disulfide exchange reactions.
YP_251895.1	N-acetylmuramoyl-L-alanine amidase cwlB precursor (EC 3.5.1.28) (Cell wall hydrolase) (Autolysin).,Autolysins are involved in some important biological processes such as cell separation cell-wall turnover competence for genetic transformation formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teichoic acid-endowed peptidoglycan.
YP_251900.1	glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA
YP_251901.1	functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria
YP_251904.1	in Escherichia coli transcription of this gene is enhanced by polyamines