-- dump date 20140619_051858 -- class Genbank::misc_feature -- table misc_feature_note -- id note 306537000001 Replicase family; Region: Replicase; pfam03090 306537000002 22-bp box element of corynebacterial plasmids 306537000003 Predicted membrane protein [Function unknown]; Region: COG3428 306537000004 Bacterial PH domain; Region: DUF304; cl01348 306537000005 Bacterial PH domain; Region: DUF304; pfam03703 306537000006 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 306537000007 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 306537000008 Walker A/P-loop; other site 306537000009 ATP binding site [chemical binding]; other site 306537000010 Q-loop/lid; other site 306537000011 ABC transporter signature motif; other site 306537000012 Walker B; other site 306537000013 D-loop; other site 306537000014 H-loop/switch region; other site 306537000015 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 306537000016 Aureocin-like type II bacteriocin; Region: Bacteriocin_IIi; pfam11758 306537000017 Transposase, Mutator family; Region: Transposase_mut; pfam00872 306537000018 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 306537000019 multiple promoter invertase; Provisional; Region: mpi; PRK13413 306537000020 catalytic residues [active] 306537000021 catalytic nucleophile [active] 306537000022 Presynaptic Site I dimer interface [polypeptide binding]; other site 306537000023 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 306537000024 Synaptic Flat tetramer interface [polypeptide binding]; other site 306537000025 Synaptic Site I dimer interface [polypeptide binding]; other site 306537000026 DNA binding site [nucleotide binding] 306537000027 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 306537000028 DNA-binding interface [nucleotide binding]; DNA binding site 306537000029 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 306537000030 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 306537000031 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 306537000032 P-loop; other site 306537000033 Magnesium ion binding site [ion binding]; other site 306537000034 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306537000035 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 306537000036 Walker A motif; other site 306537000037 ATP binding site [chemical binding]; other site 306537000038 Walker B motif; other site 306537000039 arginine finger; other site 306537000040 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 306537000041 DnaA box-binding interface [nucleotide binding]; other site 306537000042 DNA polymerase III subunit beta; Validated; Region: PRK07761 306537000043 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 306537000044 putative DNA binding surface [nucleotide binding]; other site 306537000045 dimer interface [polypeptide binding]; other site 306537000046 beta-clamp/clamp loader binding surface; other site 306537000047 beta-clamp/translesion DNA polymerase binding surface; other site 306537000048 recombination protein F; Reviewed; Region: recF; PRK00064 306537000049 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 306537000050 Walker A/P-loop; other site 306537000051 ATP binding site [chemical binding]; other site 306537000052 Q-loop/lid; other site 306537000053 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306537000054 ABC transporter signature motif; other site 306537000055 Walker B; other site 306537000056 D-loop; other site 306537000057 H-loop/switch region; other site 306537000058 Protein of unknown function (DUF721); Region: DUF721; cl02324 306537000059 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 306537000060 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 306537000061 ATP binding site [chemical binding]; other site 306537000062 Mg2+ binding site [ion binding]; other site 306537000063 G-X-G motif; other site 306537000064 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 306537000065 anchoring element; other site 306537000066 dimer interface [polypeptide binding]; other site 306537000067 ATP binding site [chemical binding]; other site 306537000068 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 306537000069 active site 306537000070 putative metal-binding site [ion binding]; other site 306537000071 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 306537000072 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 306537000073 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 306537000074 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 306537000075 Imelysin; Region: Peptidase_M75; pfam09375 306537000076 Phosphoesterase family; Region: Phosphoesterase; pfam04185 306537000077 DNA gyrase subunit A; Validated; Region: PRK05560 306537000078 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 306537000079 CAP-like domain; other site 306537000080 active site 306537000081 primary dimer interface [polypeptide binding]; other site 306537000082 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 306537000083 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 306537000084 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 306537000085 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 306537000086 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 306537000087 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 306537000088 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 306537000089 Integrase core domain; Region: rve_3; pfam13683 306537000090 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 306537000091 Helix-turn-helix domain; Region: HTH_38; pfam13936 306537000092 Integrase core domain; Region: rve; pfam00665 306537000093 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 306537000094 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 306537000095 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 306537000096 nudix motif; other site 306537000097 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 306537000098 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 306537000099 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 306537000100 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 306537000101 Helix-turn-helix domain; Region: HTH_38; pfam13936 306537000102 Integrase core domain; Region: rve; pfam00665 306537000103 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 306537000104 FIC domain binding interface [polypeptide binding]; other site 306537000105 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 306537000106 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 306537000107 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 306537000108 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 306537000109 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 306537000110 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 306537000111 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 306537000112 DNA binding residues [nucleotide binding] 306537000113 Anti-sigma-K factor rskA; Region: RskA; pfam10099 306537000114 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 306537000115 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 306537000116 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 306537000117 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 306537000118 Divergent AAA domain; Region: AAA_4; pfam04326 306537000119 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 306537000120 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 306537000121 putative DNA binding site [nucleotide binding]; other site 306537000122 putative Zn2+ binding site [ion binding]; other site 306537000123 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 306537000124 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 306537000125 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 306537000126 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 306537000127 active site 306537000128 Rhomboid family; Region: Rhomboid; pfam01694 306537000129 putative septation inhibitor protein; Reviewed; Region: PRK00159 306537000130 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 306537000131 Glutamine amidotransferase class-I; Region: GATase; pfam00117 306537000132 glutamine binding [chemical binding]; other site 306537000133 catalytic triad [active] 306537000134 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 306537000135 Catalytic domain of Protein Kinases; Region: PKc; cd00180 306537000136 active site 306537000137 ATP binding site [chemical binding]; other site 306537000138 substrate binding site [chemical binding]; other site 306537000139 activation loop (A-loop); other site 306537000140 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 306537000141 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 306537000142 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 306537000143 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 306537000144 PASTA domain; Region: PASTA; pfam03793 306537000145 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 306537000146 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 306537000147 active site 306537000148 ATP binding site [chemical binding]; other site 306537000149 substrate binding site [chemical binding]; other site 306537000150 activation loop (A-loop); other site 306537000151 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 306537000152 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 306537000153 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 306537000154 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 306537000155 Protein phosphatase 2C; Region: PP2C; pfam00481 306537000156 active site 306537000157 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 306537000158 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 306537000159 phosphopeptide binding site; other site 306537000160 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 306537000161 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 306537000162 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 306537000163 phosphopeptide binding site; other site 306537000164 MULE transposase domain; Region: MULE; pfam10551 306537000165 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 306537000166 DJ-1 family protein; Region: not_thiJ; TIGR01383 306537000167 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 306537000168 conserved cys residue [active] 306537000169 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 306537000170 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 306537000171 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 306537000172 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 306537000173 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 306537000174 CoenzymeA binding site [chemical binding]; other site 306537000175 subunit interaction site [polypeptide binding]; other site 306537000176 PHB binding site; other site 306537000177 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 306537000178 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 306537000179 active site 306537000180 DNA binding site [nucleotide binding] 306537000181 cystathionine gamma-synthase; Provisional; Region: PRK07811 306537000182 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 306537000183 homodimer interface [polypeptide binding]; other site 306537000184 substrate-cofactor binding pocket; other site 306537000185 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306537000186 catalytic residue [active] 306537000187 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 306537000188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306537000189 NAD(P) binding site [chemical binding]; other site 306537000190 active site 306537000191 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 306537000192 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 306537000193 PLD-like domain; Region: PLDc_2; pfam13091 306537000194 putative active site [active] 306537000195 catalytic site [active] 306537000196 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 306537000197 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 306537000198 ATP binding site [chemical binding]; other site 306537000199 putative Mg++ binding site [ion binding]; other site 306537000200 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 306537000201 nucleotide binding region [chemical binding]; other site 306537000202 ATP-binding site [chemical binding]; other site 306537000203 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 306537000204 Transposase, Mutator family; Region: Transposase_mut; pfam00872 306537000205 MULE transposase domain; Region: MULE; pfam10551 306537000206 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 306537000207 NAD-dependent deacetylase; Provisional; Region: PRK00481 306537000208 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 306537000209 NAD+ binding site [chemical binding]; other site 306537000210 substrate binding site [chemical binding]; other site 306537000211 Zn binding site [ion binding]; other site 306537000212 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 306537000213 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 306537000214 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 306537000215 trimer interface [polypeptide binding]; other site 306537000216 putative metal binding site [ion binding]; other site 306537000217 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 306537000218 Nitronate monooxygenase; Region: NMO; pfam03060 306537000219 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 306537000220 FMN binding site [chemical binding]; other site 306537000221 substrate binding site [chemical binding]; other site 306537000222 putative catalytic residue [active] 306537000223 Protein of unknown function, DUF488; Region: DUF488; cl01246 306537000224 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 306537000225 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 306537000226 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 306537000227 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 306537000228 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 306537000229 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 306537000230 active site 306537000231 FMN binding site [chemical binding]; other site 306537000232 2,4-decadienoyl-CoA binding site; other site 306537000233 catalytic residue [active] 306537000234 4Fe-4S cluster binding site [ion binding]; other site 306537000235 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 306537000236 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 306537000237 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 306537000238 active site 306537000239 dimer interface [polypeptide binding]; other site 306537000240 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 306537000241 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 306537000242 active site 306537000243 FMN binding site [chemical binding]; other site 306537000244 substrate binding site [chemical binding]; other site 306537000245 3Fe-4S cluster binding site [ion binding]; other site 306537000246 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 306537000247 domain interface; other site 306537000248 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 306537000249 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 306537000250 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 306537000251 S4 domain; Region: S4_2; pfam13275 306537000252 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 306537000253 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 306537000254 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 306537000255 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 306537000256 active site 306537000257 Zn binding site [ion binding]; other site 306537000258 Protease prsW family; Region: PrsW-protease; pfam13367 306537000259 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 306537000260 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 306537000261 active site 306537000262 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 306537000263 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 306537000264 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 306537000265 LabA_like proteins; Region: LabA_like; cd06167 306537000266 putative metal binding site [ion binding]; other site 306537000267 Uncharacterized conserved protein [Function unknown]; Region: COG1432 306537000268 Predicted transcriptional regulators [Transcription]; Region: COG1725 306537000269 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 306537000270 DNA-binding site [nucleotide binding]; DNA binding site 306537000271 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 306537000272 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 306537000273 Walker A/P-loop; other site 306537000274 ATP binding site [chemical binding]; other site 306537000275 Q-loop/lid; other site 306537000276 ABC transporter signature motif; other site 306537000277 Walker B; other site 306537000278 D-loop; other site 306537000279 H-loop/switch region; other site 306537000280 Transposase, Mutator family; Region: Transposase_mut; pfam00872 306537000281 MULE transposase domain; Region: MULE; pfam10551 306537000282 Transposase; Region: HTH_Tnp_1; cl17663 306537000283 putative transposase OrfB; Reviewed; Region: PHA02517 306537000284 HTH-like domain; Region: HTH_21; pfam13276 306537000285 Integrase core domain; Region: rve; pfam00665 306537000286 Integrase core domain; Region: rve_3; pfam13683 306537000287 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 306537000288 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 306537000289 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 306537000290 active site 306537000291 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 306537000292 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 306537000293 Ligand Binding Site [chemical binding]; other site 306537000294 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 306537000295 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 306537000296 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 306537000297 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 306537000298 active site 306537000299 catalytic site [active] 306537000300 Domain of unknown function (DUF2020); Region: DUF2020; pfam09449 306537000301 Lsr2; Region: Lsr2; pfam11774 306537000302 PhoD-like phosphatase; Region: PhoD; pfam09423 306537000303 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 306537000304 putative active site [active] 306537000305 putative metal binding site [ion binding]; other site 306537000306 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 306537000307 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 306537000308 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 306537000309 methionine sulfoxide reductase A; Provisional; Region: PRK00058 306537000310 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 306537000311 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 306537000312 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 306537000313 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 306537000314 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 306537000315 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 306537000316 NAD binding site [chemical binding]; other site 306537000317 dimer interface [polypeptide binding]; other site 306537000318 tetramer (dimer of dimers) interface [polypeptide binding]; other site 306537000319 substrate binding site [chemical binding]; other site 306537000320 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 306537000321 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 306537000322 active site 306537000323 catalytic site [active] 306537000324 Transcriptional regulator [Transcription]; Region: LytR; COG1316 306537000325 CAAX protease self-immunity; Region: Abi; pfam02517 306537000326 Amidase; Region: Amidase; cl11426 306537000327 prephenate dehydratase; Provisional; Region: PRK11898 306537000328 Prephenate dehydratase; Region: PDT; pfam00800 306537000329 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 306537000330 putative L-Phe binding site [chemical binding]; other site 306537000331 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 306537000332 catalytic core [active] 306537000333 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 306537000334 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 306537000335 Septum formation; Region: Septum_form; pfam13845 306537000336 Septum formation; Region: Septum_form; pfam13845 306537000337 seryl-tRNA synthetase; Provisional; Region: PRK05431 306537000338 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 306537000339 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 306537000340 dimer interface [polypeptide binding]; other site 306537000341 active site 306537000342 motif 1; other site 306537000343 motif 2; other site 306537000344 motif 3; other site 306537000345 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 306537000346 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 306537000347 putative acyl-acceptor binding pocket; other site 306537000348 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 306537000349 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 306537000350 active site 306537000351 motif I; other site 306537000352 motif II; other site 306537000353 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 306537000354 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 306537000355 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 306537000356 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 306537000357 UDP-galactopyranose mutase; Region: GLF; pfam03275 306537000358 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 306537000359 Divergent AAA domain; Region: AAA_4; pfam04326 306537000360 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 306537000361 MarR family; Region: MarR_2; pfam12802 306537000362 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 306537000363 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 306537000364 active site 306537000365 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 306537000366 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 306537000367 active site 306537000368 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 306537000369 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 306537000370 Putative esterase; Region: Esterase; pfam00756 306537000371 Putative esterase; Region: Esterase; pfam00756 306537000372 S-formylglutathione hydrolase; Region: PLN02442 306537000373 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 306537000374 LGFP repeat; Region: LGFP; pfam08310 306537000375 LGFP repeat; Region: LGFP; pfam08310 306537000376 LGFP repeat; Region: LGFP; pfam08310 306537000377 Cutinase; Region: Cutinase; pfam01083 306537000378 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 306537000379 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 306537000380 acyl-activating enzyme (AAE) consensus motif; other site 306537000381 active site 306537000382 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 306537000383 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 306537000384 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 306537000385 active site 306537000386 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 306537000387 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 306537000388 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 306537000389 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 306537000390 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 306537000391 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 306537000392 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 306537000393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306537000394 Major Facilitator Superfamily; Region: MFS_1; pfam07690 306537000395 putative substrate translocation pore; other site 306537000396 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 306537000397 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 306537000398 putative dimerization interface [polypeptide binding]; other site 306537000399 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 306537000400 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 306537000401 Predicted integral membrane protein [Function unknown]; Region: COG0392 306537000402 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 306537000403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306537000404 S-adenosylmethionine binding site [chemical binding]; other site 306537000405 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 306537000406 active site 306537000407 substrate-binding site [chemical binding]; other site 306537000408 metal-binding site [ion binding] 306537000409 GTP binding site [chemical binding]; other site 306537000410 Transposase, Mutator family; Region: Transposase_mut; pfam00872 306537000411 MULE transposase domain; Region: MULE; pfam10551 306537000412 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 306537000413 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 306537000414 catalytic residue [active] 306537000415 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 306537000416 catalytic residues [active] 306537000417 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 306537000418 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 306537000419 peroxiredoxin; Region: AhpC; TIGR03137 306537000420 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 306537000421 dimer interface [polypeptide binding]; other site 306537000422 decamer (pentamer of dimers) interface [polypeptide binding]; other site 306537000423 catalytic triad [active] 306537000424 peroxidatic and resolving cysteines [active] 306537000425 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 306537000426 Sulphur transport; Region: Sulf_transp; pfam04143 306537000427 Sulphur transport; Region: Sulf_transp; pfam04143 306537000428 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 306537000429 CPxP motif; other site 306537000430 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 306537000431 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 306537000432 metal ion-dependent adhesion site (MIDAS); other site 306537000433 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 306537000434 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 306537000435 substrate binding site [chemical binding]; other site 306537000436 oxyanion hole (OAH) forming residues; other site 306537000437 trimer interface [polypeptide binding]; other site 306537000438 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 306537000439 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 306537000440 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 306537000441 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 306537000442 dimer interface [polypeptide binding]; other site 306537000443 active site 306537000444 Methyltransferase domain; Region: Methyltransf_31; pfam13847 306537000445 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306537000446 S-adenosylmethionine binding site [chemical binding]; other site 306537000447 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 306537000448 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 306537000449 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 306537000450 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 306537000451 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 306537000452 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 306537000453 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 306537000454 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 306537000455 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 306537000456 Ligand Binding Site [chemical binding]; other site 306537000457 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 306537000458 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 306537000459 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 306537000460 VanW like protein; Region: VanW; pfam04294 306537000461 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 306537000462 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 306537000463 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 306537000464 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 306537000465 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 306537000466 trimer interface [polypeptide binding]; other site 306537000467 active site 306537000468 aminotransferase AlaT; Validated; Region: PRK09265 306537000469 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 306537000470 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306537000471 homodimer interface [polypeptide binding]; other site 306537000472 catalytic residue [active] 306537000473 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 306537000474 4Fe-4S binding domain; Region: Fer4; cl02805 306537000475 4Fe-4S binding domain; Region: Fer4; pfam00037 306537000476 Cysteine-rich domain; Region: CCG; pfam02754 306537000477 Cysteine-rich domain; Region: CCG; pfam02754 306537000478 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 306537000479 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 306537000480 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 306537000481 nucleotide binding site [chemical binding]; other site 306537000482 NEF interaction site [polypeptide binding]; other site 306537000483 SBD interface [polypeptide binding]; other site 306537000484 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 306537000485 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 306537000486 dimer interface [polypeptide binding]; other site 306537000487 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 306537000488 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 306537000489 active site 306537000490 chaperone protein DnaJ; Provisional; Region: PRK14279 306537000491 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 306537000492 HSP70 interaction site [polypeptide binding]; other site 306537000493 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 306537000494 Zn binding sites [ion binding]; other site 306537000495 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 306537000496 dimer interface [polypeptide binding]; other site 306537000497 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 306537000498 DNA binding residues [nucleotide binding] 306537000499 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 306537000500 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 306537000501 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 306537000502 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 306537000503 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 306537000504 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 306537000505 Sulfate transporter family; Region: Sulfate_transp; pfam00916 306537000506 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 306537000507 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 306537000508 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 306537000509 DNA binding site [nucleotide binding] 306537000510 active site 306537000511 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 306537000512 Predicted amidohydrolase [General function prediction only]; Region: COG0388 306537000513 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 306537000514 putative active site [active] 306537000515 catalytic triad [active] 306537000516 putative dimer interface [polypeptide binding]; other site 306537000517 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 306537000518 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 306537000519 FAD binding pocket [chemical binding]; other site 306537000520 FAD binding motif [chemical binding]; other site 306537000521 phosphate binding motif [ion binding]; other site 306537000522 beta-alpha-beta structure motif; other site 306537000523 NAD binding pocket [chemical binding]; other site 306537000524 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 306537000525 CoA-transferase family III; Region: CoA_transf_3; pfam02515 306537000526 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 306537000527 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 306537000528 active site 306537000529 LabA_like proteins; Region: LabA_like; cd06167 306537000530 putative metal binding site [ion binding]; other site 306537000531 Uncharacterized conserved protein [Function unknown]; Region: COG1432 306537000532 Transcriptional regulator [Transcription]; Region: IclR; COG1414 306537000533 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 306537000534 DctM-like transporters; Region: DctM; pfam06808 306537000535 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 306537000536 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 306537000537 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 306537000538 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 306537000539 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 306537000540 Clp amino terminal domain; Region: Clp_N; pfam02861 306537000541 Clp amino terminal domain; Region: Clp_N; pfam02861 306537000542 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306537000543 Walker A motif; other site 306537000544 ATP binding site [chemical binding]; other site 306537000545 Walker B motif; other site 306537000546 arginine finger; other site 306537000547 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306537000548 Walker A motif; other site 306537000549 ATP binding site [chemical binding]; other site 306537000550 Walker B motif; other site 306537000551 arginine finger; other site 306537000552 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 306537000553 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 306537000554 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 306537000555 NAD(P) binding site [chemical binding]; other site 306537000556 catalytic residues [active] 306537000557 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 306537000558 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 306537000559 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 306537000560 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 306537000561 active site residue [active] 306537000562 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 306537000563 active site residue [active] 306537000564 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 306537000565 HPr interaction site; other site 306537000566 glycerol kinase (GK) interaction site [polypeptide binding]; other site 306537000567 active site 306537000568 phosphorylation site [posttranslational modification] 306537000569 short chain dehydrogenase; Provisional; Region: PRK06179 306537000570 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 306537000571 NADP binding site [chemical binding]; other site 306537000572 active site 306537000573 steroid binding site; other site 306537000574 glycine dehydrogenase; Provisional; Region: PRK05367 306537000575 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 306537000576 tetramer interface [polypeptide binding]; other site 306537000577 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306537000578 catalytic residue [active] 306537000579 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 306537000580 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 306537000581 catalytic residue [active] 306537000582 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 306537000583 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 306537000584 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 306537000585 lipoyl attachment site [posttranslational modification]; other site 306537000586 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 306537000587 active site 306537000588 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 306537000589 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 306537000590 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 306537000591 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 306537000592 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 306537000593 active site 306537000594 intersubunit interface [polypeptide binding]; other site 306537000595 zinc binding site [ion binding]; other site 306537000596 Na+ binding site [ion binding]; other site 306537000597 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 306537000598 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 306537000599 putative catalytic site [active] 306537000600 putative metal binding site [ion binding]; other site 306537000601 putative phosphate binding site [ion binding]; other site 306537000602 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 306537000603 Rib/alpha-like repeat; Region: Rib; cl07159 306537000604 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 306537000605 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 306537000606 GDP-binding site [chemical binding]; other site 306537000607 ACT binding site; other site 306537000608 IMP binding site; other site 306537000609 Transposase; Region: DEDD_Tnp_IS110; pfam01548 306537000610 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 306537000611 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 306537000612 4-coumarate--CoA ligase; Region: PLN02246 306537000613 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904 306537000614 acyl-activating enzyme (AAE) consensus motif; other site 306537000615 active site 306537000616 putative CoA binding site [chemical binding]; other site 306537000617 AMP binding site [chemical binding]; other site 306537000618 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 306537000619 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 306537000620 dimer interface [polypeptide binding]; other site 306537000621 putative radical transfer pathway; other site 306537000622 diiron center [ion binding]; other site 306537000623 tyrosyl radical; other site 306537000624 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 306537000625 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 306537000626 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 306537000627 Phosphotransferase enzyme family; Region: APH; pfam01636 306537000628 putative active site [active] 306537000629 putative substrate binding site [chemical binding]; other site 306537000630 ATP binding site [chemical binding]; other site 306537000631 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 306537000632 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 306537000633 active site 306537000634 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 306537000635 classical (c) SDRs; Region: SDR_c; cd05233 306537000636 NAD(P) binding site [chemical binding]; other site 306537000637 active site 306537000638 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 306537000639 catalytic core [active] 306537000640 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 306537000641 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 306537000642 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 306537000643 active site 306537000644 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 306537000645 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 306537000646 THF binding site; other site 306537000647 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 306537000648 substrate binding site [chemical binding]; other site 306537000649 THF binding site; other site 306537000650 zinc-binding site [ion binding]; other site 306537000651 Cobalt transport protein; Region: CbiQ; cl00463 306537000652 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306537000653 ABC transporter signature motif; other site 306537000654 Walker B; other site 306537000655 D-loop; other site 306537000656 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306537000657 Walker A/P-loop; other site 306537000658 ATP binding site [chemical binding]; other site 306537000659 Q-loop/lid; other site 306537000660 ABC transporter signature motif; other site 306537000661 Walker B; other site 306537000662 D-loop; other site 306537000663 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 306537000664 iron-sulfur cluster [ion binding]; other site 306537000665 [2Fe-2S] cluster binding site [ion binding]; other site 306537000666 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 306537000667 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306537000668 ATP-grasp domain; Region: ATP-grasp; pfam02222 306537000669 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 306537000670 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 306537000671 active site residue [active] 306537000672 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 306537000673 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 306537000674 Coenzyme A binding pocket [chemical binding]; other site 306537000675 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 306537000676 ferredoxin-NADP+ reductase; Region: PLN02852 306537000677 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 306537000678 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 306537000679 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 306537000680 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 306537000681 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 306537000682 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 306537000683 Active Sites [active] 306537000684 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 306537000685 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 306537000686 Active Sites [active] 306537000687 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 306537000688 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 306537000689 CysD dimerization site [polypeptide binding]; other site 306537000690 G1 box; other site 306537000691 putative GEF interaction site [polypeptide binding]; other site 306537000692 GTP/Mg2+ binding site [chemical binding]; other site 306537000693 Switch I region; other site 306537000694 G2 box; other site 306537000695 G3 box; other site 306537000696 Switch II region; other site 306537000697 G4 box; other site 306537000698 G5 box; other site 306537000699 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 306537000700 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 306537000701 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 306537000702 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 306537000703 putative active site [active] 306537000704 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 306537000705 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 306537000706 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 306537000707 propionate/acetate kinase; Provisional; Region: PRK12379 306537000708 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 306537000709 Catalytic domain of Protein Kinases; Region: PKc; cd00180 306537000710 active site 306537000711 ATP binding site [chemical binding]; other site 306537000712 substrate binding site [chemical binding]; other site 306537000713 activation loop (A-loop); other site 306537000714 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 306537000715 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 306537000716 substrate binding pocket [chemical binding]; other site 306537000717 membrane-bound complex binding site; other site 306537000718 hinge residues; other site 306537000719 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 306537000720 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 306537000721 Walker A/P-loop; other site 306537000722 ATP binding site [chemical binding]; other site 306537000723 Q-loop/lid; other site 306537000724 ABC transporter signature motif; other site 306537000725 Walker B; other site 306537000726 D-loop; other site 306537000727 H-loop/switch region; other site 306537000728 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 306537000729 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 306537000730 Transcriptional regulators [Transcription]; Region: MarR; COG1846 306537000731 MarR family; Region: MarR_2; pfam12802 306537000732 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 306537000733 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 306537000734 putative active site [active] 306537000735 catalytic site [active] 306537000736 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 306537000737 putative active site [active] 306537000738 catalytic site [active] 306537000739 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 306537000740 putative catalytic site [active] 306537000741 putative metal binding site [ion binding]; other site 306537000742 putative phosphate binding site [ion binding]; other site 306537000743 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 306537000744 Coenzyme A binding pocket [chemical binding]; other site 306537000745 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 306537000746 active site 306537000747 catalytic residues [active] 306537000748 metal binding site [ion binding]; metal-binding site 306537000749 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 306537000750 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 306537000751 carboxylate-amine ligase; Provisional; Region: PRK13517 306537000752 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 306537000753 2-isopropylmalate synthase; Validated; Region: PRK03739 306537000754 hypothetical protein; Provisional; Region: PRK07907 306537000755 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 306537000756 active site 306537000757 metal binding site [ion binding]; metal-binding site 306537000758 dimer interface [polypeptide binding]; other site 306537000759 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 306537000760 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 306537000761 ring oligomerisation interface [polypeptide binding]; other site 306537000762 ATP/Mg binding site [chemical binding]; other site 306537000763 stacking interactions; other site 306537000764 hinge regions; other site 306537000765 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 306537000766 The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); Region: A_NRPS_SidN3_like; cd05918 306537000767 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 306537000768 acyl-activating enzyme (AAE) consensus motif; other site 306537000769 AMP binding site [chemical binding]; other site 306537000770 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 306537000771 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 306537000772 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 306537000773 putative CoA binding site [chemical binding]; other site 306537000774 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 306537000775 putative trimer interface [polypeptide binding]; other site 306537000776 putative CoA binding site [chemical binding]; other site 306537000777 Transcriptional regulators [Transcription]; Region: MarR; COG1846 306537000778 MarR family; Region: MarR_2; pfam12802 306537000779 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 306537000780 active site residue [active] 306537000781 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 306537000782 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 306537000783 Soluble P-type ATPase [General function prediction only]; Region: COG4087 306537000784 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 306537000785 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 306537000786 dimer interface [polypeptide binding]; other site 306537000787 substrate binding site [chemical binding]; other site 306537000788 metal binding sites [ion binding]; metal-binding site 306537000789 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 306537000790 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 306537000791 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 306537000792 TilS substrate binding domain; Region: TilS; pfam09179 306537000793 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 306537000794 active site 306537000795 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 306537000796 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306537000797 Walker A motif; other site 306537000798 ATP binding site [chemical binding]; other site 306537000799 Walker B motif; other site 306537000800 arginine finger; other site 306537000801 Peptidase family M41; Region: Peptidase_M41; pfam01434 306537000802 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 306537000803 homodecamer interface [polypeptide binding]; other site 306537000804 GTP cyclohydrolase I; Provisional; Region: PLN03044 306537000805 active site 306537000806 putative catalytic site residues [active] 306537000807 zinc binding site [ion binding]; other site 306537000808 GTP-CH-I/GFRP interaction surface; other site 306537000809 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 306537000810 dihydropteroate synthase; Region: DHPS; TIGR01496 306537000811 substrate binding pocket [chemical binding]; other site 306537000812 dimer interface [polypeptide binding]; other site 306537000813 inhibitor binding site; inhibition site 306537000814 Dihydroneopterin aldolase; Region: FolB; pfam02152 306537000815 active site 306537000816 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 306537000817 catalytic center binding site [active] 306537000818 ATP binding site [chemical binding]; other site 306537000819 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 306537000820 Rossmann-like domain; Region: Rossmann-like; pfam10727 306537000821 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 306537000822 Pantoate-beta-alanine ligase; Region: PanC; cd00560 306537000823 pantoate--beta-alanine ligase; Region: panC; TIGR00018 306537000824 active site 306537000825 ATP-binding site [chemical binding]; other site 306537000826 pantoate-binding site; other site 306537000827 HXXH motif; other site 306537000828 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 306537000829 active site 306537000830 catalytic residues [active] 306537000831 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 306537000832 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 306537000833 Na binding site [ion binding]; other site 306537000834 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 306537000835 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 306537000836 nucleotide binding site/active site [active] 306537000837 HIT family signature motif; other site 306537000838 catalytic residue [active] 306537000839 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 306537000840 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 306537000841 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 306537000842 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 306537000843 tetramerization interface [polypeptide binding]; other site 306537000844 active site 306537000845 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 306537000846 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 306537000847 dimer interface [polypeptide binding]; other site 306537000848 putative anticodon binding site; other site 306537000849 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 306537000850 motif 1; other site 306537000851 dimer interface [polypeptide binding]; other site 306537000852 active site 306537000853 motif 2; other site 306537000854 motif 3; other site 306537000855 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 306537000856 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 306537000857 active site 306537000858 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 306537000859 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 306537000860 active site 306537000861 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 306537000862 dimer interface [polypeptide binding]; other site 306537000863 substrate binding site [chemical binding]; other site 306537000864 ATP binding site [chemical binding]; other site 306537000865 acyl-CoA synthetase; Provisional; Region: PRK13382 306537000866 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 306537000867 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 306537000868 acyl-activating enzyme (AAE) consensus motif; other site 306537000869 AMP binding site [chemical binding]; other site 306537000870 active site 306537000871 CoA binding site [chemical binding]; other site 306537000872 Clp protease ATP binding subunit; Region: clpC; CHL00095 306537000873 Clp amino terminal domain; Region: Clp_N; pfam02861 306537000874 Clp amino terminal domain; Region: Clp_N; pfam02861 306537000875 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306537000876 Walker A motif; other site 306537000877 ATP binding site [chemical binding]; other site 306537000878 Walker B motif; other site 306537000879 arginine finger; other site 306537000880 UvrB/uvrC motif; Region: UVR; pfam02151 306537000881 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306537000882 Walker A motif; other site 306537000883 ATP binding site [chemical binding]; other site 306537000884 Walker B motif; other site 306537000885 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 306537000886 Secretory lipase; Region: LIP; pfam03583 306537000887 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 306537000888 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 306537000889 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 306537000890 minor groove reading motif; other site 306537000891 helix-hairpin-helix signature motif; other site 306537000892 active site 306537000893 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 306537000894 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 306537000895 active site clefts [active] 306537000896 zinc binding site [ion binding]; other site 306537000897 dimer interface [polypeptide binding]; other site 306537000898 DNA repair protein RadA; Provisional; Region: PRK11823 306537000899 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 306537000900 Walker A motif; other site 306537000901 ATP binding site [chemical binding]; other site 306537000902 Walker B motif; other site 306537000903 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 306537000904 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 306537000905 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 306537000906 substrate binding site; other site 306537000907 dimer interface; other site 306537000908 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Reviewed; Region: ispF; PRK00084 306537000909 homotrimer interaction site [polypeptide binding]; other site 306537000910 zinc binding site [ion binding]; other site 306537000911 CDP-binding sites; other site 306537000912 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 306537000913 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306537000914 Walker A/P-loop; other site 306537000915 ATP binding site [chemical binding]; other site 306537000916 Q-loop/lid; other site 306537000917 ABC transporter signature motif; other site 306537000918 Walker B; other site 306537000919 D-loop; other site 306537000920 H-loop/switch region; other site 306537000921 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 306537000922 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 306537000923 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 306537000924 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 306537000925 active site 306537000926 HIGH motif; other site 306537000927 nucleotide binding site [chemical binding]; other site 306537000928 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 306537000929 KMSKS motif; other site 306537000930 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 306537000931 tRNA binding surface [nucleotide binding]; other site 306537000932 anticodon binding site; other site 306537000933 Htaa; Region: HtaA; pfam04213 306537000934 Htaa; Region: HtaA; pfam04213 306537000935 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 306537000936 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 306537000937 intersubunit interface [polypeptide binding]; other site 306537000938 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 306537000939 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 306537000940 ABC-ATPase subunit interface; other site 306537000941 dimer interface [polypeptide binding]; other site 306537000942 putative PBP binding regions; other site 306537000943 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 306537000944 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 306537000945 Walker A/P-loop; other site 306537000946 ATP binding site [chemical binding]; other site 306537000947 Q-loop/lid; other site 306537000948 ABC transporter signature motif; other site 306537000949 Walker B; other site 306537000950 D-loop; other site 306537000951 H-loop/switch region; other site 306537000952 Htaa; Region: HtaA; pfam04213 306537000953 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 306537000954 heme binding pocket [chemical binding]; other site 306537000955 heme ligand [chemical binding]; other site 306537000956 Htaa; Region: HtaA; pfam04213 306537000957 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 306537000958 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 306537000959 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 306537000960 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 306537000961 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 306537000962 Carboxylesterase family; Region: COesterase; pfam00135 306537000963 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 306537000964 substrate binding pocket [chemical binding]; other site 306537000965 catalytic triad [active] 306537000966 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 306537000967 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 306537000968 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 306537000969 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306537000970 Walker A/P-loop; other site 306537000971 ATP binding site [chemical binding]; other site 306537000972 Q-loop/lid; other site 306537000973 ABC transporter signature motif; other site 306537000974 Walker B; other site 306537000975 D-loop; other site 306537000976 H-loop/switch region; other site 306537000977 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 306537000978 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 306537000979 intersubunit interface [polypeptide binding]; other site 306537000980 Transcriptional regulators [Transcription]; Region: PurR; COG1609 306537000981 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 306537000982 DNA binding site [nucleotide binding] 306537000983 domain linker motif; other site 306537000984 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 306537000985 putative dimerization interface [polypeptide binding]; other site 306537000986 putative ligand binding site [chemical binding]; other site 306537000987 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 306537000988 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 306537000989 META domain; Region: META; cl01245 306537000990 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 306537000991 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 306537000992 active site 306537000993 homotetramer interface [polypeptide binding]; other site 306537000994 Uncharacterized conserved protein [Function unknown]; Region: COG2966 306537000995 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 306537000996 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 306537000997 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 306537000998 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 306537000999 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 306537001000 Transposase, Mutator family; Region: Transposase_mut; pfam00872 306537001001 MULE transposase domain; Region: MULE; pfam10551 306537001002 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 306537001003 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 306537001004 Coenzyme A binding pocket [chemical binding]; other site 306537001005 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 306537001006 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 306537001007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 306537001008 active site 306537001009 phosphorylation site [posttranslational modification] 306537001010 intermolecular recognition site; other site 306537001011 dimerization interface [polypeptide binding]; other site 306537001012 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 306537001013 DNA binding site [nucleotide binding] 306537001014 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 306537001015 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 306537001016 dimerization interface [polypeptide binding]; other site 306537001017 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 306537001018 dimer interface [polypeptide binding]; other site 306537001019 phosphorylation site [posttranslational modification] 306537001020 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 306537001021 ATP binding site [chemical binding]; other site 306537001022 Mg2+ binding site [ion binding]; other site 306537001023 G-X-G motif; other site 306537001024 Transposase; Region: DEDD_Tnp_IS110; pfam01548 306537001025 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 306537001026 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 306537001027 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 306537001028 Lipase (class 2); Region: Lipase_2; pfam01674 306537001029 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 306537001030 nucleotide binding site/active site [active] 306537001031 HIT family signature motif; other site 306537001032 catalytic residue [active] 306537001033 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 306537001034 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 306537001035 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 306537001036 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 306537001037 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 306537001038 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 306537001039 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 306537001040 TrkA-N domain; Region: TrkA_N; pfam02254 306537001041 TrkA-C domain; Region: TrkA_C; pfam02080 306537001042 adenylosuccinate lyase; Region: purB; TIGR00928 306537001043 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 306537001044 tetramer interface [polypeptide binding]; other site 306537001045 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 306537001046 ATP binding site [chemical binding]; other site 306537001047 active site 306537001048 substrate binding site [chemical binding]; other site 306537001049 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 306537001050 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 306537001051 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 306537001052 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 306537001053 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 306537001054 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 306537001055 putative active site [active] 306537001056 catalytic triad [active] 306537001057 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 306537001058 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 306537001059 dimerization interface [polypeptide binding]; other site 306537001060 ATP binding site [chemical binding]; other site 306537001061 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 306537001062 dimerization interface [polypeptide binding]; other site 306537001063 ATP binding site [chemical binding]; other site 306537001064 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 306537001065 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 306537001066 amidophosphoribosyltransferase; Provisional; Region: PRK07847 306537001067 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 306537001068 active site 306537001069 tetramer interface [polypeptide binding]; other site 306537001070 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 306537001071 active site 306537001072 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 306537001073 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 306537001074 dimerization interface [polypeptide binding]; other site 306537001075 putative ATP binding site [chemical binding]; other site 306537001076 MULE transposase domain; Region: MULE; pfam10551 306537001077 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 306537001078 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 306537001079 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306537001080 ABC transporter signature motif; other site 306537001081 Walker B; other site 306537001082 D-loop; other site 306537001083 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 306537001084 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 306537001085 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306537001086 Walker A/P-loop; other site 306537001087 ATP binding site [chemical binding]; other site 306537001088 Q-loop/lid; other site 306537001089 ABC transporter signature motif; other site 306537001090 Walker B; other site 306537001091 D-loop; other site 306537001092 H-loop/switch region; other site 306537001093 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 306537001094 substrate binding site [chemical binding]; other site 306537001095 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 306537001096 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 306537001097 quinone interaction residues [chemical binding]; other site 306537001098 active site 306537001099 catalytic residues [active] 306537001100 FMN binding site [chemical binding]; other site 306537001101 substrate binding site [chemical binding]; other site 306537001102 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 306537001103 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 306537001104 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 306537001105 active site 306537001106 HIGH motif; other site 306537001107 nucleotide binding site [chemical binding]; other site 306537001108 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 306537001109 active site 306537001110 KMSKS motif; other site 306537001111 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 306537001112 tRNA binding surface [nucleotide binding]; other site 306537001113 anticodon binding site; other site 306537001114 MULE transposase domain; Region: MULE; pfam10551 306537001115 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 306537001116 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 306537001117 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 306537001118 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 306537001119 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 306537001120 homodimer interface [polypeptide binding]; other site 306537001121 substrate-cofactor binding pocket; other site 306537001122 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306537001123 catalytic residue [active] 306537001124 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 306537001125 heme-binding site [chemical binding]; other site 306537001126 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 306537001127 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 306537001128 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 306537001129 PBP superfamily domain; Region: PBP_like_2; cl17296 306537001130 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 306537001131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 306537001132 dimer interface [polypeptide binding]; other site 306537001133 conserved gate region; other site 306537001134 putative PBP binding loops; other site 306537001135 ABC-ATPase subunit interface; other site 306537001136 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 306537001137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 306537001138 dimer interface [polypeptide binding]; other site 306537001139 conserved gate region; other site 306537001140 putative PBP binding loops; other site 306537001141 ABC-ATPase subunit interface; other site 306537001142 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 306537001143 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 306537001144 Walker A/P-loop; other site 306537001145 ATP binding site [chemical binding]; other site 306537001146 Q-loop/lid; other site 306537001147 ABC transporter signature motif; other site 306537001148 Walker B; other site 306537001149 D-loop; other site 306537001150 H-loop/switch region; other site 306537001151 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 306537001152 AAA domain; Region: AAA_33; pfam13671 306537001153 ATP-binding site [chemical binding]; other site 306537001154 Gluconate-6-phosphate binding site [chemical binding]; other site 306537001155 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 306537001156 PhoU domain; Region: PhoU; pfam01895 306537001157 PhoU domain; Region: PhoU; pfam01895 306537001158 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 306537001159 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 306537001160 FMN binding site [chemical binding]; other site 306537001161 active site 306537001162 catalytic residues [active] 306537001163 substrate binding site [chemical binding]; other site 306537001164 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 306537001165 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 306537001166 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 306537001167 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 306537001168 MULE transposase domain; Region: MULE; pfam10551 306537001169 Transposase; Region: HTH_Tnp_1; cl17663 306537001170 HTH-like domain; Region: HTH_21; pfam13276 306537001171 Transposase, Mutator family; Region: Transposase_mut; pfam00872 306537001172 MULE transposase domain; Region: MULE; pfam10551 306537001173 Integrase core domain; Region: rve; pfam00665 306537001174 Integrase core domain; Region: rve_3; pfam13683 306537001175 MULE transposase domain; Region: MULE; pfam10551 306537001176 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 306537001177 Coenzyme A binding pocket [chemical binding]; other site 306537001178 serine O-acetyltransferase; Region: cysE; TIGR01172 306537001179 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 306537001180 trimer interface [polypeptide binding]; other site 306537001181 active site 306537001182 substrate binding site [chemical binding]; other site 306537001183 CoA binding site [chemical binding]; other site 306537001184 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 306537001185 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 306537001186 dimer interface [polypeptide binding]; other site 306537001187 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306537001188 catalytic residue [active] 306537001189 enoyl-CoA hydratase; Provisional; Region: PRK05862 306537001190 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 306537001191 substrate binding site [chemical binding]; other site 306537001192 oxyanion hole (OAH) forming residues; other site 306537001193 trimer interface [polypeptide binding]; other site 306537001194 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 306537001195 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 306537001196 DNA binding residues [nucleotide binding] 306537001197 dimerization interface [polypeptide binding]; other site 306537001198 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 306537001199 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 306537001200 hinge; other site 306537001201 active site 306537001202 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 306537001203 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 306537001204 Walker A/P-loop; other site 306537001205 ATP binding site [chemical binding]; other site 306537001206 Q-loop/lid; other site 306537001207 ABC transporter signature motif; other site 306537001208 Walker B; other site 306537001209 D-loop; other site 306537001210 H-loop/switch region; other site 306537001211 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 306537001212 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 306537001213 FtsX-like permease family; Region: FtsX; pfam02687 306537001214 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 306537001215 FtsX-like permease family; Region: FtsX; pfam02687 306537001216 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 306537001217 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 306537001218 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 306537001219 hypothetical protein; Provisional; Region: PRK05463 306537001220 Transcriptional regulators [Transcription]; Region: GntR; COG1802 306537001221 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 306537001222 DNA-binding site [nucleotide binding]; DNA binding site 306537001223 FCD domain; Region: FCD; pfam07729 306537001224 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 306537001225 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 306537001226 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 306537001227 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 306537001228 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 306537001229 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 306537001230 carboxyltransferase (CT) interaction site; other site 306537001231 biotinylation site [posttranslational modification]; other site 306537001232 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 306537001233 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 306537001234 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 306537001235 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 306537001236 putative active site [active] 306537001237 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 306537001238 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 306537001239 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 306537001240 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 306537001241 ATP binding site [chemical binding]; other site 306537001242 putative Mg++ binding site [ion binding]; other site 306537001243 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 306537001244 nucleotide binding region [chemical binding]; other site 306537001245 ATP-binding site [chemical binding]; other site 306537001246 Transcriptional regulator [Transcription]; Region: LysR; COG0583 306537001247 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 306537001248 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 306537001249 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 306537001250 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 306537001251 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 306537001252 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 306537001253 ATP binding site [chemical binding]; other site 306537001254 putative Mg++ binding site [ion binding]; other site 306537001255 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 306537001256 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 306537001257 Protein of unknown function (DUF3235); Region: DUF3235; pfam11574 306537001258 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 306537001259 DNA-binding site [nucleotide binding]; DNA binding site 306537001260 RNA-binding motif; other site 306537001261 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 306537001262 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 306537001263 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 306537001264 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 306537001265 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 306537001266 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 306537001267 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 306537001268 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 306537001269 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 306537001270 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 306537001271 catalytic residue [active] 306537001272 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 306537001273 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 306537001274 dimer interface [polypeptide binding]; other site 306537001275 active site 306537001276 citrylCoA binding site [chemical binding]; other site 306537001277 NADH binding [chemical binding]; other site 306537001278 cationic pore residues; other site 306537001279 oxalacetate/citrate binding site [chemical binding]; other site 306537001280 coenzyme A binding site [chemical binding]; other site 306537001281 catalytic triad [active] 306537001282 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 306537001283 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 306537001284 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 306537001285 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 306537001286 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306537001287 Walker A/P-loop; other site 306537001288 ATP binding site [chemical binding]; other site 306537001289 Q-loop/lid; other site 306537001290 ABC transporter signature motif; other site 306537001291 Walker B; other site 306537001292 D-loop; other site 306537001293 H-loop/switch region; other site 306537001294 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 306537001295 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 306537001296 active site 306537001297 catalytic tetrad [active] 306537001298 enoyl-CoA hydratase; Provisional; Region: PRK06144 306537001299 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 306537001300 substrate binding site [chemical binding]; other site 306537001301 oxyanion hole (OAH) forming residues; other site 306537001302 trimer interface [polypeptide binding]; other site 306537001303 Helix-turn-helix domain; Region: HTH_28; pfam13518 306537001304 Winged helix-turn helix; Region: HTH_29; pfam13551 306537001305 Homeodomain-like domain; Region: HTH_32; pfam13565 306537001306 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 306537001307 Integrase core domain; Region: rve; pfam00665 306537001308 Integrase core domain; Region: rve_3; pfam13683 306537001309 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 306537001310 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 306537001311 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 306537001312 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 306537001313 Walker A/P-loop; other site 306537001314 ATP binding site [chemical binding]; other site 306537001315 Q-loop/lid; other site 306537001316 ABC transporter signature motif; other site 306537001317 Walker B; other site 306537001318 D-loop; other site 306537001319 H-loop/switch region; other site 306537001320 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306537001321 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 306537001322 Walker A/P-loop; other site 306537001323 ATP binding site [chemical binding]; other site 306537001324 Q-loop/lid; other site 306537001325 ABC transporter signature motif; other site 306537001326 Walker B; other site 306537001327 D-loop; other site 306537001328 H-loop/switch region; other site 306537001329 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 306537001330 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 306537001331 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306537001332 Walker A/P-loop; other site 306537001333 ATP binding site [chemical binding]; other site 306537001334 Q-loop/lid; other site 306537001335 ABC transporter signature motif; other site 306537001336 Walker B; other site 306537001337 D-loop; other site 306537001338 H-loop/switch region; other site 306537001339 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 306537001340 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306537001341 Walker A/P-loop; other site 306537001342 ATP binding site [chemical binding]; other site 306537001343 Q-loop/lid; other site 306537001344 ABC transporter signature motif; other site 306537001345 Walker B; other site 306537001346 D-loop; other site 306537001347 H-loop/switch region; other site 306537001348 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 306537001349 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 306537001350 folate binding site [chemical binding]; other site 306537001351 NADP+ binding site [chemical binding]; other site 306537001352 thymidylate synthase; Reviewed; Region: thyA; PRK01827 306537001353 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 306537001354 dimerization interface [polypeptide binding]; other site 306537001355 active site 306537001356 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 306537001357 Lipase (class 2); Region: Lipase_2; pfam01674 306537001358 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 306537001359 Lipase (class 2); Region: Lipase_2; pfam01674 306537001360 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 306537001361 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 306537001362 active site 306537001363 DEAD-like helicases superfamily; Region: DEXDc; smart00487 306537001364 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 306537001365 ATP binding site [chemical binding]; other site 306537001366 putative Mg++ binding site [ion binding]; other site 306537001367 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 306537001368 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 306537001369 nucleotide binding region [chemical binding]; other site 306537001370 ATP-binding site [chemical binding]; other site 306537001371 DEAD/H associated; Region: DEAD_assoc; pfam08494 306537001372 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 306537001373 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 306537001374 putative DNA binding site [nucleotide binding]; other site 306537001375 catalytic residue [active] 306537001376 putative H2TH interface [polypeptide binding]; other site 306537001377 putative catalytic residues [active] 306537001378 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 306537001379 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 306537001380 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 306537001381 active site 306537001382 dimer interface [polypeptide binding]; other site 306537001383 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 306537001384 dimer interface [polypeptide binding]; other site 306537001385 active site 306537001386 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 306537001387 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 306537001388 tetramerization interface [polypeptide binding]; other site 306537001389 NAD(P) binding site [chemical binding]; other site 306537001390 catalytic residues [active] 306537001391 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 306537001392 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 306537001393 active site 306537001394 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 306537001395 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 306537001396 active site 306537001397 peptide chain release factor 2; Validated; Region: prfB; PRK00578 306537001398 This domain is found in peptide chain release factors; Region: PCRF; smart00937 306537001399 RF-1 domain; Region: RF-1; pfam00472 306537001400 Proline dehydrogenase; Region: Pro_dh; cl03282 306537001401 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 306537001402 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 306537001403 Glutamate binding site [chemical binding]; other site 306537001404 NAD binding site [chemical binding]; other site 306537001405 catalytic residues [active] 306537001406 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 306537001407 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 306537001408 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 306537001409 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306537001410 Walker A/P-loop; other site 306537001411 ATP binding site [chemical binding]; other site 306537001412 Q-loop/lid; other site 306537001413 ABC transporter signature motif; other site 306537001414 Walker B; other site 306537001415 D-loop; other site 306537001416 H-loop/switch region; other site 306537001417 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 306537001418 FtsX-like permease family; Region: FtsX; pfam02687 306537001419 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 306537001420 SmpB-tmRNA interface; other site 306537001421 Transposase, Mutator family; Region: Transposase_mut; pfam00872 306537001422 MULE transposase domain; Region: MULE; pfam10551 306537001423 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 306537001424 domain interaction interfaces [polypeptide binding]; other site 306537001425 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 306537001426 domain interaction interfaces [polypeptide binding]; other site 306537001427 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 306537001428 domain interaction interfaces [polypeptide binding]; other site 306537001429 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 306537001430 domain interaction interfaces [polypeptide binding]; other site 306537001431 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 306537001432 domain interaction interfaces [polypeptide binding]; other site 306537001433 DEAD-like helicases superfamily; Region: DEXDc; smart00487 306537001434 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 306537001435 ATP binding site [chemical binding]; other site 306537001436 putative Mg++ binding site [ion binding]; other site 306537001437 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 306537001438 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 306537001439 Predicted permease [General function prediction only]; Region: COG2056 306537001440 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 306537001441 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 306537001442 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 306537001443 active site 306537001444 metal binding site [ion binding]; metal-binding site 306537001445 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 306537001446 acyl-CoA synthetase; Validated; Region: PRK08162 306537001447 acyl-activating enzyme (AAE) consensus motif; other site 306537001448 putative active site [active] 306537001449 AMP binding site [chemical binding]; other site 306537001450 putative CoA binding site [chemical binding]; other site 306537001451 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 306537001452 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 306537001453 phosphoglucomutase; Validated; Region: PRK07564 306537001454 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 306537001455 active site 306537001456 substrate binding site [chemical binding]; other site 306537001457 metal binding site [ion binding]; metal-binding site 306537001458 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 306537001459 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 306537001460 catalytic residues [active] 306537001461 MULE transposase domain; Region: MULE; pfam10551 306537001462 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 306537001463 Helix-turn-helix domain; Region: HTH_28; pfam13518 306537001464 HTH-like domain; Region: HTH_21; pfam13276 306537001465 Integrase core domain; Region: rve; pfam00665 306537001466 Integrase core domain; Region: rve_2; pfam13333 306537001467 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 306537001468 putative active site [active] 306537001469 redox center [active] 306537001470 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 306537001471 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 306537001472 homodimer interface [polypeptide binding]; other site 306537001473 NAD binding pocket [chemical binding]; other site 306537001474 ATP binding pocket [chemical binding]; other site 306537001475 Mg binding site [ion binding]; other site 306537001476 active-site loop [active] 306537001477 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 306537001478 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 306537001479 catalytic residues [active] 306537001480 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 306537001481 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 306537001482 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 306537001483 Class I ribonucleotide reductase; Region: RNR_I; cd01679 306537001484 active site 306537001485 dimer interface [polypeptide binding]; other site 306537001486 catalytic residues [active] 306537001487 effector binding site; other site 306537001488 R2 peptide binding site; other site 306537001489 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 306537001490 Ferritin-like domain; Region: Ferritin; pfam00210 306537001491 ferroxidase diiron center [ion binding]; other site 306537001492 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 306537001493 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 306537001494 dimer interface [polypeptide binding]; other site 306537001495 putative radical transfer pathway; other site 306537001496 diiron center [ion binding]; other site 306537001497 tyrosyl radical; other site 306537001498 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 306537001499 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 306537001500 D-pathway; other site 306537001501 Putative ubiquinol binding site [chemical binding]; other site 306537001502 Low-spin heme (heme b) binding site [chemical binding]; other site 306537001503 Putative water exit pathway; other site 306537001504 Binuclear center (heme o3/CuB) [ion binding]; other site 306537001505 K-pathway; other site 306537001506 Putative proton exit pathway; other site 306537001507 Transposase; Region: DEDD_Tnp_IS110; pfam01548 306537001508 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 306537001509 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 306537001510 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 306537001511 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 306537001512 phosphoserine phosphatase SerB; Region: serB; TIGR00338 306537001513 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 306537001514 motif II; other site 306537001515 4-coumarate--CoA ligase; Region: PLN02246 306537001516 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904 306537001517 acyl-activating enzyme (AAE) consensus motif; other site 306537001518 active site 306537001519 putative CoA binding site [chemical binding]; other site 306537001520 AMP binding site [chemical binding]; other site 306537001521 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 306537001522 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 306537001523 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 306537001524 DNA binding residues [nucleotide binding] 306537001525 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 306537001526 nucleotide binding site [chemical binding]; other site 306537001527 putative NEF/HSP70 interaction site [polypeptide binding]; other site 306537001528 SBD interface [polypeptide binding]; other site 306537001529 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 306537001530 Dynamin family; Region: Dynamin_N; pfam00350 306537001531 G1 box; other site 306537001532 GTP/Mg2+ binding site [chemical binding]; other site 306537001533 G2 box; other site 306537001534 Switch I region; other site 306537001535 G3 box; other site 306537001536 Switch II region; other site 306537001537 Dynamin family; Region: Dynamin_N; pfam00350 306537001538 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 306537001539 G1 box; other site 306537001540 GTP/Mg2+ binding site [chemical binding]; other site 306537001541 G2 box; other site 306537001542 Switch I region; other site 306537001543 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 306537001544 G3 box; other site 306537001545 Switch II region; other site 306537001546 GTP/Mg2+ binding site [chemical binding]; other site 306537001547 G4 box; other site 306537001548 G5 box; other site 306537001549 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 306537001550 DEAD/DEAH box helicase; Region: DEAD; pfam00270 306537001551 ATP binding site [chemical binding]; other site 306537001552 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 306537001553 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 306537001554 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 306537001555 active site 306537001556 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 306537001557 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 306537001558 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 306537001559 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 306537001560 cleavage site 306537001561 glutamate racemase; Provisional; Region: PRK00865 306537001562 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 306537001563 ribonuclease PH; Reviewed; Region: rph; PRK00173 306537001564 Ribonuclease PH; Region: RNase_PH_bact; cd11362 306537001565 hexamer interface [polypeptide binding]; other site 306537001566 active site 306537001567 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 306537001568 active site 306537001569 dimerization interface [polypeptide binding]; other site 306537001570 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 306537001571 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 306537001572 metal binding site [ion binding]; metal-binding site 306537001573 putative dimer interface [polypeptide binding]; other site 306537001574 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 306537001575 Glucitol operon activator protein (GutM); Region: GutM; cl01890 306537001576 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 306537001577 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 306537001578 catalytic triad [active] 306537001579 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 306537001580 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 306537001581 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 306537001582 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 306537001583 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 306537001584 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 306537001585 Transposase, Mutator family; Region: Transposase_mut; pfam00872 306537001586 MULE transposase domain; Region: MULE; pfam10551 306537001587 putative transposase OrfB; Reviewed; Region: PHA02517 306537001588 HTH-like domain; Region: HTH_21; pfam13276 306537001589 Integrase core domain; Region: rve; pfam00665 306537001590 Integrase core domain; Region: rve_3; pfam13683 306537001591 Transposase; Region: HTH_Tnp_1; cl17663 306537001592 MULE transposase domain; Region: MULE; pfam10551 306537001593 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 306537001594 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 306537001595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 306537001596 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 306537001597 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 306537001598 active site lid residues [active] 306537001599 substrate binding pocket [chemical binding]; other site 306537001600 catalytic residues [active] 306537001601 substrate-Mg2+ binding site; other site 306537001602 aspartate-rich region 1; other site 306537001603 aspartate-rich region 2; other site 306537001604 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 306537001605 metal-binding site [ion binding] 306537001606 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 306537001607 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 306537001608 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 306537001609 catalytic site [active] 306537001610 putative active site [active] 306537001611 putative substrate binding site [chemical binding]; other site 306537001612 dimer interface [polypeptide binding]; other site 306537001613 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 306537001614 classical (c) SDRs; Region: SDR_c; cd05233 306537001615 NAD(P) binding site [chemical binding]; other site 306537001616 active site 306537001617 Transposase; Region: DEDD_Tnp_IS110; pfam01548 306537001618 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 306537001619 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 306537001620 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 306537001621 active site 306537001622 NTP binding site [chemical binding]; other site 306537001623 metal binding triad [ion binding]; metal-binding site 306537001624 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 306537001625 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 306537001626 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 306537001627 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 306537001628 DNA methylase; Region: N6_N4_Mtase; pfam01555 306537001629 DNA methylase; Region: N6_N4_Mtase; pfam01555 306537001630 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509 306537001631 Winged helix-turn helix; Region: HTH_29; pfam13551 306537001632 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 306537001633 DNA-binding interface [nucleotide binding]; DNA binding site 306537001634 Homeodomain-like domain; Region: HTH_32; pfam13565 306537001635 Integrase core domain; Region: rve; pfam00665 306537001636 Integrase core domain; Region: rve_3; pfam13683 306537001637 Helix-turn-helix domain; Region: HTH_28; pfam13518 306537001638 Winged helix-turn helix; Region: HTH_29; pfam13551 306537001639 Homeodomain-like domain; Region: HTH_32; pfam13565 306537001640 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 306537001641 Integrase core domain; Region: rve; pfam00665 306537001642 Integrase core domain; Region: rve_3; pfam13683 306537001643 Transposase, Mutator family; Region: Transposase_mut; pfam00872 306537001644 MULE transposase domain; Region: MULE; pfam10551 306537001645 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 306537001646 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 306537001647 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 306537001648 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 306537001649 dimer interface [polypeptide binding]; other site 306537001650 ssDNA binding site [nucleotide binding]; other site 306537001651 tetramer (dimer of dimers) interface [polypeptide binding]; other site 306537001652 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 306537001653 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 306537001654 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 306537001655 ABC transporter; Region: ABC_tran_2; pfam12848 306537001656 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 306537001657 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 306537001658 active site 306537001659 hypothetical protein; Provisional; Region: PRK10621 306537001660 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 306537001661 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 306537001662 apolar tunnel; other site 306537001663 heme binding site [chemical binding]; other site 306537001664 dimerization interface [polypeptide binding]; other site 306537001665 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 306537001666 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 306537001667 Zn binding site [ion binding]; other site 306537001668 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 306537001669 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 306537001670 trigger factor; Provisional; Region: tig; PRK01490 306537001671 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 306537001672 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 306537001673 Clp protease; Region: CLP_protease; pfam00574 306537001674 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 306537001675 oligomer interface [polypeptide binding]; other site 306537001676 active site residues [active] 306537001677 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 306537001678 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 306537001679 oligomer interface [polypeptide binding]; other site 306537001680 active site residues [active] 306537001681 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 306537001682 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 306537001683 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306537001684 Walker A motif; other site 306537001685 ATP binding site [chemical binding]; other site 306537001686 Walker B motif; other site 306537001687 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 306537001688 malate dehydrogenase; Provisional; Region: PRK05442 306537001689 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 306537001690 NAD(P) binding site [chemical binding]; other site 306537001691 dimer interface [polypeptide binding]; other site 306537001692 malate binding site [chemical binding]; other site 306537001693 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 306537001694 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 306537001695 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 306537001696 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 306537001697 active site 306537001698 HIGH motif; other site 306537001699 nucleotide binding site [chemical binding]; other site 306537001700 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 306537001701 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 306537001702 active site 306537001703 KMSKS motif; other site 306537001704 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 306537001705 tRNA binding surface [nucleotide binding]; other site 306537001706 anticodon binding site; other site 306537001707 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 306537001708 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 306537001709 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 306537001710 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 306537001711 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 306537001712 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 306537001713 amidase catalytic site [active] 306537001714 Zn binding residues [ion binding]; other site 306537001715 substrate binding site [chemical binding]; other site 306537001716 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 306537001717 active site 306537001718 multimer interface [polypeptide binding]; other site 306537001719 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 306537001720 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 306537001721 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 306537001722 homodimer interface [polypeptide binding]; other site 306537001723 oligonucleotide binding site [chemical binding]; other site 306537001724 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 306537001725 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 306537001726 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 306537001727 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 306537001728 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 306537001729 Walker A/P-loop; other site 306537001730 ATP binding site [chemical binding]; other site 306537001731 Q-loop/lid; other site 306537001732 ABC transporter signature motif; other site 306537001733 Walker B; other site 306537001734 D-loop; other site 306537001735 H-loop/switch region; other site 306537001736 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 306537001737 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 306537001738 ABC-ATPase subunit interface; other site 306537001739 dimer interface [polypeptide binding]; other site 306537001740 putative PBP binding regions; other site 306537001741 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 306537001742 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 306537001743 putative ligand binding residues [chemical binding]; other site 306537001744 GTPase CgtA; Reviewed; Region: obgE; PRK12296 306537001745 GTP1/OBG; Region: GTP1_OBG; pfam01018 306537001746 Obg GTPase; Region: Obg; cd01898 306537001747 G1 box; other site 306537001748 GTP/Mg2+ binding site [chemical binding]; other site 306537001749 Switch I region; other site 306537001750 G2 box; other site 306537001751 G3 box; other site 306537001752 Switch II region; other site 306537001753 G4 box; other site 306537001754 G5 box; other site 306537001755 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 306537001756 gamma-glutamyl kinase; Provisional; Region: PRK05429 306537001757 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 306537001758 nucleotide binding site [chemical binding]; other site 306537001759 homotetrameric interface [polypeptide binding]; other site 306537001760 putative phosphate binding site [ion binding]; other site 306537001761 putative allosteric binding site; other site 306537001762 PUA domain; Region: PUA; pfam01472 306537001763 DoxX-like family; Region: DoxX_2; pfam13564 306537001764 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 306537001765 putative catalytic cysteine [active] 306537001766 YwiC-like protein; Region: YwiC; pfam14256 306537001767 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 306537001768 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 306537001769 active site 306537001770 (T/H)XGH motif; other site 306537001771 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 306537001772 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 306537001773 catalytic core [active] 306537001774 EDD domain protein, DegV family; Region: DegV; TIGR00762 306537001775 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 306537001776 SLBB domain; Region: SLBB; pfam10531 306537001777 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 306537001778 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 306537001779 Competence protein; Region: Competence; pfam03772 306537001780 hypothetical protein; Validated; Region: PRK05629 306537001781 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 306537001782 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 306537001783 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 306537001784 PemK-like protein; Region: PemK; pfam02452 306537001785 GTP-binding protein LepA; Provisional; Region: PRK05433 306537001786 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 306537001787 G1 box; other site 306537001788 putative GEF interaction site [polypeptide binding]; other site 306537001789 GTP/Mg2+ binding site [chemical binding]; other site 306537001790 Switch I region; other site 306537001791 G2 box; other site 306537001792 G3 box; other site 306537001793 Switch II region; other site 306537001794 G4 box; other site 306537001795 G5 box; other site 306537001796 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 306537001797 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 306537001798 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 306537001799 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 306537001800 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 306537001801 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 306537001802 putative NAD(P) binding site [chemical binding]; other site 306537001803 bile acid transporter; Region: bass; TIGR00841 306537001804 Sodium Bile acid symporter family; Region: SBF; pfam01758 306537001805 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 306537001806 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 306537001807 active site 306537001808 metal binding site [ion binding]; metal-binding site 306537001809 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 306537001810 MULE transposase domain; Region: MULE; pfam10551 306537001811 BCCT family transporter; Region: BCCT; pfam02028 306537001812 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 306537001813 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 306537001814 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 306537001815 CsbD-like; Region: CsbD; pfam05532 306537001816 hypothetical protein; Provisional; Region: PRK06062 306537001817 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 306537001818 inhibitor-cofactor binding pocket; inhibition site 306537001819 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306537001820 catalytic residue [active] 306537001821 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 306537001822 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 306537001823 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 306537001824 Walker A/P-loop; other site 306537001825 ATP binding site [chemical binding]; other site 306537001826 Q-loop/lid; other site 306537001827 ABC transporter signature motif; other site 306537001828 Walker B; other site 306537001829 D-loop; other site 306537001830 H-loop/switch region; other site 306537001831 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 306537001832 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 306537001833 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306537001834 homodimer interface [polypeptide binding]; other site 306537001835 catalytic residue [active] 306537001836 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 306537001837 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 306537001838 substrate binding pocket [chemical binding]; other site 306537001839 catalytic triad [active] 306537001840 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 306537001841 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 306537001842 active site 306537001843 Zn binding site [ion binding]; other site 306537001844 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 306537001845 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 306537001846 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 306537001847 acyl-activating enzyme (AAE) consensus motif; other site 306537001848 putative AMP binding site [chemical binding]; other site 306537001849 putative active site [active] 306537001850 putative CoA binding site [chemical binding]; other site 306537001851 coproporphyrinogen III oxidase; Validated; Region: PRK05628 306537001852 HemN C-terminal domain; Region: HemN_C; pfam06969 306537001853 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 306537001854 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 306537001855 DNA-binding site [nucleotide binding]; DNA binding site 306537001856 chaperone protein DnaJ; Provisional; Region: PRK14278 306537001857 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 306537001858 HSP70 interaction site [polypeptide binding]; other site 306537001859 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 306537001860 Zn binding sites [ion binding]; other site 306537001861 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 306537001862 dimer interface [polypeptide binding]; other site 306537001863 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 306537001864 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 306537001865 PhoH-like protein; Region: PhoH; pfam02562 306537001866 metal-binding heat shock protein; Provisional; Region: PRK00016 306537001867 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 306537001868 Domain of unknown function DUF21; Region: DUF21; pfam01595 306537001869 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 306537001870 Transporter associated domain; Region: CorC_HlyC; smart01091 306537001871 GTPase Era; Reviewed; Region: era; PRK00089 306537001872 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 306537001873 G1 box; other site 306537001874 GTP/Mg2+ binding site [chemical binding]; other site 306537001875 Switch I region; other site 306537001876 G2 box; other site 306537001877 Switch II region; other site 306537001878 G3 box; other site 306537001879 G4 box; other site 306537001880 G5 box; other site 306537001881 KH domain; Region: KH_2; pfam07650 306537001882 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 306537001883 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 306537001884 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 306537001885 Recombination protein O N terminal; Region: RecO_N; pfam11967 306537001886 Recombination protein O C terminal; Region: RecO_C; pfam02565 306537001887 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 306537001888 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 306537001889 catalytic residue [active] 306537001890 putative FPP diphosphate binding site; other site 306537001891 putative FPP binding hydrophobic cleft; other site 306537001892 dimer interface [polypeptide binding]; other site 306537001893 putative IPP diphosphate binding site; other site 306537001894 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 306537001895 diiron binding motif [ion binding]; other site 306537001896 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 306537001897 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 306537001898 metal binding site 2 [ion binding]; metal-binding site 306537001899 putative DNA binding helix; other site 306537001900 metal binding site 1 [ion binding]; metal-binding site 306537001901 dimer interface [polypeptide binding]; other site 306537001902 structural Zn2+ binding site [ion binding]; other site 306537001903 glycyl-tRNA synthetase; Provisional; Region: PRK04173 306537001904 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 306537001905 motif 1; other site 306537001906 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 306537001907 active site 306537001908 motif 2; other site 306537001909 motif 3; other site 306537001910 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 306537001911 anticodon binding site; other site 306537001912 Transposase; Region: DEDD_Tnp_IS110; pfam01548 306537001913 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 306537001914 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 306537001915 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 306537001916 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 306537001917 Repair protein; Region: Repair_PSII; pfam04536 306537001918 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 306537001919 putative active site [active] 306537001920 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 306537001921 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 306537001922 Zn2+ binding site [ion binding]; other site 306537001923 Mg2+ binding site [ion binding]; other site 306537001924 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 306537001925 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 306537001926 active site 306537001927 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 306537001928 Helix-turn-helix domain; Region: HTH_38; pfam13936 306537001929 Integrase core domain; Region: rve; pfam00665 306537001930 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 306537001931 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 306537001932 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 306537001933 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 306537001934 nudix motif; other site 306537001935 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 306537001936 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 306537001937 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 306537001938 Helix-turn-helix domain; Region: HTH_38; pfam13936 306537001939 Integrase core domain; Region: rve; pfam00665 306537001940 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 306537001941 active site 306537001942 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 306537001943 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 306537001944 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 306537001945 DNA primase; Validated; Region: dnaG; PRK05667 306537001946 CHC2 zinc finger; Region: zf-CHC2; cl17510 306537001947 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 306537001948 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 306537001949 active site 306537001950 metal binding site [ion binding]; metal-binding site 306537001951 interdomain interaction site; other site 306537001952 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 306537001953 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 306537001954 Transposase, Mutator family; Region: Transposase_mut; pfam00872 306537001955 MULE transposase domain; Region: MULE; pfam10551 306537001956 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 306537001957 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 306537001958 NAD binding site [chemical binding]; other site 306537001959 catalytic Zn binding site [ion binding]; other site 306537001960 substrate binding site [chemical binding]; other site 306537001961 structural Zn binding site [ion binding]; other site 306537001962 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 306537001963 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 306537001964 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 306537001965 metal-binding site [ion binding] 306537001966 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 306537001967 Soluble P-type ATPase [General function prediction only]; Region: COG4087 306537001968 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 306537001969 putative homotetramer interface [polypeptide binding]; other site 306537001970 putative homodimer interface [polypeptide binding]; other site 306537001971 putative allosteric switch controlling residues; other site 306537001972 putative metal binding site [ion binding]; other site 306537001973 putative homodimer-homodimer interface [polypeptide binding]; other site 306537001974 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 306537001975 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 306537001976 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 306537001977 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 306537001978 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 306537001979 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 306537001980 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 306537001981 CT1975-like protein; Region: Cas_CT1975; pfam09344 306537001982 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 306537001983 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 306537001984 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 306537001985 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 306537001986 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 306537001987 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 306537001988 dimer interface [polypeptide binding]; other site 306537001989 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 306537001990 Helix-turn-helix domain; Region: HTH_28; pfam13518 306537001991 HTH-like domain; Region: HTH_21; pfam13276 306537001992 Integrase core domain; Region: rve; pfam00665 306537001993 Integrase core domain; Region: rve_2; pfam13333 306537001994 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 306537001995 FMN binding site [chemical binding]; other site 306537001996 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 306537001997 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 306537001998 Walker A/P-loop; other site 306537001999 ATP binding site [chemical binding]; other site 306537002000 Q-loop/lid; other site 306537002001 ABC transporter signature motif; other site 306537002002 Walker B; other site 306537002003 D-loop; other site 306537002004 H-loop/switch region; other site 306537002005 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 306537002006 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 306537002007 substrate binding pocket [chemical binding]; other site 306537002008 membrane-bound complex binding site; other site 306537002009 hinge residues; other site 306537002010 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 306537002011 dimer interface [polypeptide binding]; other site 306537002012 conserved gate region; other site 306537002013 putative PBP binding loops; other site 306537002014 ABC-ATPase subunit interface; other site 306537002015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 306537002016 dimer interface [polypeptide binding]; other site 306537002017 conserved gate region; other site 306537002018 putative PBP binding loops; other site 306537002019 ABC-ATPase subunit interface; other site 306537002020 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 306537002021 Beta-lactamase; Region: Beta-lactamase; pfam00144 306537002022 acyl carrier protein; Provisional; Region: acpP; PRK00982 306537002023 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 306537002024 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 306537002025 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 306537002026 dimer interface [polypeptide binding]; other site 306537002027 TPP-binding site [chemical binding]; other site 306537002028 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 306537002029 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 306537002030 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 306537002031 MULE transposase domain; Region: MULE; pfam10551 306537002032 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 306537002033 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 306537002034 Low molecular weight phosphatase family; Region: LMWPc; cd00115 306537002035 active site 306537002036 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 306537002037 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 306537002038 active site 306537002039 motif II; other site 306537002040 Uncharacterized conserved protein [Function unknown]; Region: COG0327 306537002041 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 306537002042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 306537002043 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 306537002044 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 306537002045 Putative zinc ribbon domain; Region: DUF164; pfam02591 306537002046 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 306537002047 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 306537002048 RNA/DNA hybrid binding site [nucleotide binding]; other site 306537002049 active site 306537002050 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 306537002051 catalytic core [active] 306537002052 RNB domain; Region: RNB; pfam00773 306537002053 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 306537002054 Domain of unknown function (DUF202); Region: DUF202; cl09954 306537002055 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 306537002056 oligomerization interface [polypeptide binding]; other site 306537002057 active site 306537002058 metal binding site [ion binding]; metal-binding site 306537002059 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 306537002060 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 306537002061 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 306537002062 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 306537002063 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 306537002064 metal binding triad; other site 306537002065 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 306537002066 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 306537002067 metal binding triad; other site 306537002068 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 306537002069 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 306537002070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306537002071 Major Facilitator Superfamily; Region: MFS_1; pfam07690 306537002072 putative substrate translocation pore; other site 306537002073 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 306537002074 hydrophobic ligand binding site; other site 306537002075 biotin synthase; Validated; Region: PRK06256 306537002076 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 306537002077 FeS/SAM binding site; other site 306537002078 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 306537002079 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 306537002080 Fructosamine kinase; Region: Fructosamin_kin; cl17579 306537002081 Uncharacterized membrane protein [Function unknown]; Region: COG3949 306537002082 Predicted membrane protein [Function unknown]; Region: COG2323 306537002083 Predicted membrane protein [Function unknown]; Region: COG1511 306537002084 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 306537002085 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 306537002086 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 306537002087 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 306537002088 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306537002089 Walker A/P-loop; other site 306537002090 ATP binding site [chemical binding]; other site 306537002091 Q-loop/lid; other site 306537002092 VIT family; Region: VIT1; pfam01988 306537002093 HTH-like domain; Region: HTH_21; pfam13276 306537002094 Integrase core domain; Region: rve; pfam00665 306537002095 Integrase core domain; Region: rve_3; pfam13683 306537002096 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 306537002097 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 306537002098 active site 306537002099 catalytic site [active] 306537002100 substrate binding site [chemical binding]; other site 306537002101 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 306537002102 putative transposase OrfB; Reviewed; Region: PHA02517 306537002103 HTH-like domain; Region: HTH_21; pfam13276 306537002104 Integrase core domain; Region: rve; pfam00665 306537002105 Integrase core domain; Region: rve_3; pfam13683 306537002106 Domain of unknown function (DUF955); Region: DUF955; cl01076 306537002107 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 306537002108 sequence-specific DNA binding site [nucleotide binding]; other site 306537002109 salt bridge; other site 306537002110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306537002111 putative substrate translocation pore; other site 306537002112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306537002113 glutamine synthetase, type I; Region: GlnA; TIGR00653 306537002114 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 306537002115 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 306537002116 RDD family; Region: RDD; pfam06271 306537002117 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 306537002118 lipoyl synthase; Provisional; Region: PRK05481 306537002119 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 306537002120 FeS/SAM binding site; other site 306537002121 lipoate-protein ligase B; Provisional; Region: PRK14345 306537002122 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 306537002123 E3 interaction surface; other site 306537002124 lipoyl attachment site [posttranslational modification]; other site 306537002125 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 306537002126 E3 interaction surface; other site 306537002127 lipoyl attachment site [posttranslational modification]; other site 306537002128 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 306537002129 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 306537002130 E3 interaction surface; other site 306537002131 lipoyl attachment site [posttranslational modification]; other site 306537002132 e3 binding domain; Region: E3_binding; pfam02817 306537002133 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 306537002134 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 306537002135 interface (dimer of trimers) [polypeptide binding]; other site 306537002136 multifunctional aminopeptidase A; Provisional; Region: PRK00913 306537002137 Substrate-binding/catalytic site; other site 306537002138 Zn-binding sites [ion binding]; other site 306537002139 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 306537002140 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 306537002141 homodimer interface [polypeptide binding]; other site 306537002142 substrate-cofactor binding pocket; other site 306537002143 catalytic residue [active] 306537002144 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 306537002145 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 306537002146 active site pocket [active] 306537002147 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 306537002148 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 306537002149 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 306537002150 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 306537002151 dimer interface [polypeptide binding]; other site 306537002152 active site 306537002153 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 306537002154 Ligand Binding Site [chemical binding]; other site 306537002155 Molecular Tunnel; other site 306537002156 pyruvate dehydrogenase; Provisional; Region: PRK06546 306537002157 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 306537002158 PYR/PP interface [polypeptide binding]; other site 306537002159 dimer interface [polypeptide binding]; other site 306537002160 tetramer interface [polypeptide binding]; other site 306537002161 TPP binding site [chemical binding]; other site 306537002162 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 306537002163 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 306537002164 TPP-binding site [chemical binding]; other site 306537002165 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 306537002166 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 306537002167 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 306537002168 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 306537002169 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 306537002170 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 306537002171 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 306537002172 Subunit I/III interface [polypeptide binding]; other site 306537002173 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 306537002174 Cytochrome c; Region: Cytochrom_C; pfam00034 306537002175 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 306537002176 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 306537002177 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 306537002178 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 306537002179 iron-sulfur cluster [ion binding]; other site 306537002180 [2Fe-2S] cluster binding site [ion binding]; other site 306537002181 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 306537002182 heme bH binding site [chemical binding]; other site 306537002183 intrachain domain interface; other site 306537002184 heme bL binding site [chemical binding]; other site 306537002185 interchain domain interface [polypeptide binding]; other site 306537002186 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 306537002187 Qo binding site; other site 306537002188 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 306537002189 active site 306537002190 catalytic site [active] 306537002191 substrate binding site [chemical binding]; other site 306537002192 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 306537002193 NlpC/P60 family; Region: NLPC_P60; pfam00877 306537002194 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 306537002195 NlpC/P60 family; Region: NLPC_P60; pfam00877 306537002196 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 306537002197 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 306537002198 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 306537002199 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 306537002200 nucleotide binding site [chemical binding]; other site 306537002201 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 306537002202 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 306537002203 putative acyl-acceptor binding pocket; other site 306537002204 Predicted membrane protein [Function unknown]; Region: COG4763 306537002205 Acyltransferase family; Region: Acyl_transf_3; pfam01757 306537002206 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 306537002207 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 306537002208 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 306537002209 active site 306537002210 ATP binding site [chemical binding]; other site 306537002211 substrate binding site [chemical binding]; other site 306537002212 activation loop (A-loop); other site 306537002213 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 306537002214 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 306537002215 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 306537002216 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 306537002217 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 306537002218 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 306537002219 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 306537002220 phytoene desaturase; Region: crtI_fam; TIGR02734 306537002221 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 306537002222 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 306537002223 substrate binding pocket [chemical binding]; other site 306537002224 chain length determination region; other site 306537002225 substrate-Mg2+ binding site; other site 306537002226 catalytic residues [active] 306537002227 aspartate-rich region 1; other site 306537002228 active site lid residues [active] 306537002229 aspartate-rich region 2; other site 306537002230 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 306537002231 FAD binding site [chemical binding]; other site 306537002232 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 306537002233 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 306537002234 Coenzyme A binding pocket [chemical binding]; other site 306537002235 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 306537002236 cell division protein MraZ; Reviewed; Region: PRK00326 306537002237 MraZ protein; Region: MraZ; pfam02381 306537002238 MraZ protein; Region: MraZ; pfam02381 306537002239 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 306537002240 MraW methylase family; Region: Methyltransf_5; cl17771 306537002241 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 306537002242 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 306537002243 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 306537002244 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 306537002245 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 306537002246 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 306537002247 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 306537002248 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 306537002249 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 306537002250 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 306537002251 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 306537002252 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 306537002253 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 306537002254 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 306537002255 Mg++ binding site [ion binding]; other site 306537002256 putative catalytic motif [active] 306537002257 putative substrate binding site [chemical binding]; other site 306537002258 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141 306537002259 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 306537002260 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 306537002261 cell division protein FtsW; Region: ftsW; TIGR02614 306537002262 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 306537002263 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 306537002264 active site 306537002265 homodimer interface [polypeptide binding]; other site 306537002266 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 306537002267 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 306537002268 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 306537002269 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 306537002270 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 306537002271 Cell division protein FtsQ; Region: FtsQ; pfam03799 306537002272 cell division protein FtsZ; Validated; Region: PRK09330 306537002273 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 306537002274 nucleotide binding site [chemical binding]; other site 306537002275 SulA interaction site; other site 306537002276 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 306537002277 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 306537002278 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 306537002279 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 306537002280 catalytic residue [active] 306537002281 Protein of unknown function (DUF552); Region: DUF552; pfam04472 306537002282 DivIVA domain; Region: DivI1A_domain; TIGR03544 306537002283 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 306537002284 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 306537002285 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 306537002286 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 306537002287 HIGH motif; other site 306537002288 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 306537002289 active site 306537002290 KMSKS motif; other site 306537002291 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 306537002292 tRNA binding surface [nucleotide binding]; other site 306537002293 anticodon binding site; other site 306537002294 DNA polymerase IV; Provisional; Region: PRK03348 306537002295 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 306537002296 active site 306537002297 DNA binding site [nucleotide binding] 306537002298 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 306537002299 active site 306537002300 homotetramer interface [polypeptide binding]; other site 306537002301 homodimer interface [polypeptide binding]; other site 306537002302 lipoprotein signal peptidase; Provisional; Region: PRK14787 306537002303 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 306537002304 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 306537002305 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 306537002306 active site 306537002307 Predicted permeases [General function prediction only]; Region: RarD; COG2962 306537002308 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 306537002309 FAD binding domain; Region: FAD_binding_4; pfam01565 306537002310 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 306537002311 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 306537002312 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 306537002313 dimer interface [polypeptide binding]; other site 306537002314 active site 306537002315 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 306537002316 substrate binding site [chemical binding]; other site 306537002317 catalytic residue [active] 306537002318 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 306537002319 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 306537002320 active site 306537002321 PHP Thumb interface [polypeptide binding]; other site 306537002322 metal binding site [ion binding]; metal-binding site 306537002323 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 306537002324 generic binding surface II; other site 306537002325 generic binding surface I; other site 306537002326 pyruvate kinase; Provisional; Region: PRK14725 306537002327 active site 306537002328 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 306537002329 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 306537002330 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 306537002331 catalytic site [active] 306537002332 active site 306537002333 Uncharacterized conserved protein [Function unknown]; Region: COG1739 306537002334 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 306537002335 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 306537002336 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 306537002337 RNA binding surface [nucleotide binding]; other site 306537002338 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 306537002339 synthetase active site [active] 306537002340 NTP binding site [chemical binding]; other site 306537002341 metal binding site [ion binding]; metal-binding site 306537002342 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 306537002343 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 306537002344 active site 306537002345 catalytic site [active] 306537002346 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 306537002347 Dimer interface [polypeptide binding]; other site 306537002348 BRCT sequence motif; other site 306537002349 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 306537002350 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 306537002351 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 306537002352 active site 306537002353 catalytic site [active] 306537002354 quinolinate synthetase; Provisional; Region: PRK09375 306537002355 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 306537002356 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 306537002357 dimerization interface [polypeptide binding]; other site 306537002358 active site 306537002359 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 306537002360 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 306537002361 NAD binding site [chemical binding]; other site 306537002362 dimerization interface [polypeptide binding]; other site 306537002363 product binding site; other site 306537002364 substrate binding site [chemical binding]; other site 306537002365 zinc binding site [ion binding]; other site 306537002366 catalytic residues [active] 306537002367 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 306537002368 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 306537002369 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306537002370 homodimer interface [polypeptide binding]; other site 306537002371 catalytic residue [active] 306537002372 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 306537002373 putative active site pocket [active] 306537002374 4-fold oligomerization interface [polypeptide binding]; other site 306537002375 metal binding residues [ion binding]; metal-binding site 306537002376 3-fold/trimer interface [polypeptide binding]; other site 306537002377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306537002378 Major Facilitator Superfamily; Region: MFS_1; pfam07690 306537002379 putative substrate translocation pore; other site 306537002380 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 306537002381 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 306537002382 putative active site [active] 306537002383 oxyanion strand; other site 306537002384 catalytic triad [active] 306537002385 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 306537002386 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 306537002387 catalytic residues [active] 306537002388 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 306537002389 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 306537002390 active site 306537002391 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 306537002392 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 306537002393 substrate binding site [chemical binding]; other site 306537002394 glutamase interaction surface [polypeptide binding]; other site 306537002395 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 306537002396 anthranilate synthase component I; Provisional; Region: PRK13571 306537002397 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 306537002398 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 306537002399 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 306537002400 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 306537002401 active site 306537002402 ribulose/triose binding site [chemical binding]; other site 306537002403 phosphate binding site [ion binding]; other site 306537002404 substrate (anthranilate) binding pocket [chemical binding]; other site 306537002405 product (indole) binding pocket [chemical binding]; other site 306537002406 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 306537002407 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 306537002408 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306537002409 catalytic residue [active] 306537002410 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 306537002411 substrate binding site [chemical binding]; other site 306537002412 active site 306537002413 catalytic residues [active] 306537002414 heterodimer interface [polypeptide binding]; other site 306537002415 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 306537002416 pyruvate kinase; Provisional; Region: PRK06247 306537002417 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 306537002418 domain interfaces; other site 306537002419 active site 306537002420 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 306537002421 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 306537002422 metal binding site [ion binding]; metal-binding site 306537002423 putative dimer interface [polypeptide binding]; other site 306537002424 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 306537002425 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 306537002426 nucleotide binding site/active site [active] 306537002427 HIT family signature motif; other site 306537002428 catalytic residue [active] 306537002429 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 306537002430 active site 306537002431 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 306537002432 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 306537002433 Walker A/P-loop; other site 306537002434 ATP binding site [chemical binding]; other site 306537002435 Q-loop/lid; other site 306537002436 ABC transporter signature motif; other site 306537002437 Walker B; other site 306537002438 D-loop; other site 306537002439 H-loop/switch region; other site 306537002440 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 306537002441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 306537002442 dimer interface [polypeptide binding]; other site 306537002443 conserved gate region; other site 306537002444 putative PBP binding loops; other site 306537002445 ABC-ATPase subunit interface; other site 306537002446 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 306537002447 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 306537002448 substrate binding pocket [chemical binding]; other site 306537002449 membrane-bound complex binding site; other site 306537002450 hinge residues; other site 306537002451 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 306537002452 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 306537002453 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 306537002454 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 306537002455 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 306537002456 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 306537002457 Homeodomain-like domain; Region: HTH_23; cl17451 306537002458 Winged helix-turn helix; Region: HTH_29; pfam13551 306537002459 Integrase core domain; Region: rve; pfam00665 306537002460 Integrase core domain; Region: rve_3; pfam13683 306537002461 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 306537002462 putative dimer interface [polypeptide binding]; other site 306537002463 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 306537002464 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 306537002465 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 306537002466 DNA polymerase I; Provisional; Region: PRK05755 306537002467 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 306537002468 active site 306537002469 metal binding site 1 [ion binding]; metal-binding site 306537002470 putative 5' ssDNA interaction site; other site 306537002471 metal binding site 3; metal-binding site 306537002472 metal binding site 2 [ion binding]; metal-binding site 306537002473 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 306537002474 putative DNA binding site [nucleotide binding]; other site 306537002475 putative metal binding site [ion binding]; other site 306537002476 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 306537002477 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 306537002478 active site 306537002479 DNA binding site [nucleotide binding] 306537002480 catalytic site [active] 306537002481 Domain of unknown function (DUF368); Region: DUF368; pfam04018 306537002482 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 306537002483 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 306537002484 RNA binding site [nucleotide binding]; other site 306537002485 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 306537002486 RNA binding site [nucleotide binding]; other site 306537002487 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 306537002488 RNA binding site [nucleotide binding]; other site 306537002489 S1 RNA binding domain; Region: S1; pfam00575 306537002490 RNA binding site [nucleotide binding]; other site 306537002491 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 306537002492 active site 306537002493 catalytic site [active] 306537002494 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 306537002495 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306537002496 NAD(P) binding site [chemical binding]; other site 306537002497 active site 306537002498 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 306537002499 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 306537002500 dimer interface [polypeptide binding]; other site 306537002501 active site 306537002502 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 306537002503 dephospho-CoA kinase; Region: TIGR00152 306537002504 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 306537002505 CoA-binding site [chemical binding]; other site 306537002506 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 306537002507 putative active site [active] 306537002508 excinuclease ABC subunit B; Provisional; Region: PRK05298 306537002509 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 306537002510 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 306537002511 nucleotide binding region [chemical binding]; other site 306537002512 ATP-binding site [chemical binding]; other site 306537002513 Ultra-violet resistance protein B; Region: UvrB; pfam12344 306537002514 UvrB/uvrC motif; Region: UVR; pfam02151 306537002515 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 306537002516 Ligand Binding Site [chemical binding]; other site 306537002517 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 306537002518 Part of AAA domain; Region: AAA_19; pfam13245 306537002519 Family description; Region: UvrD_C_2; pfam13538 306537002520 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 306537002521 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 306537002522 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 306537002523 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 306537002524 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 306537002525 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 306537002526 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 306537002527 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 306537002528 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 306537002529 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 306537002530 23S rRNA binding site [nucleotide binding]; other site 306537002531 L21 binding site [polypeptide binding]; other site 306537002532 L13 binding site [polypeptide binding]; other site 306537002533 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 306537002534 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 306537002535 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 306537002536 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 306537002537 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 306537002538 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 306537002539 dimer interface [polypeptide binding]; other site 306537002540 motif 1; other site 306537002541 active site 306537002542 motif 2; other site 306537002543 motif 3; other site 306537002544 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 306537002545 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 306537002546 putative tRNA-binding site [nucleotide binding]; other site 306537002547 B3/4 domain; Region: B3_4; pfam03483 306537002548 tRNA synthetase B5 domain; Region: B5; smart00874 306537002549 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 306537002550 dimer interface [polypeptide binding]; other site 306537002551 motif 1; other site 306537002552 motif 3; other site 306537002553 motif 2; other site 306537002554 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 306537002555 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 306537002556 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 306537002557 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 306537002558 heterotetramer interface [polypeptide binding]; other site 306537002559 active site pocket [active] 306537002560 cleavage site 306537002561 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 306537002562 feedback inhibition sensing region; other site 306537002563 homohexameric interface [polypeptide binding]; other site 306537002564 nucleotide binding site [chemical binding]; other site 306537002565 N-acetyl-L-glutamate binding site [chemical binding]; other site 306537002566 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 306537002567 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 306537002568 inhibitor-cofactor binding pocket; inhibition site 306537002569 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306537002570 catalytic residue [active] 306537002571 ornithine carbamoyltransferase; Provisional; Region: PRK00779 306537002572 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 306537002573 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 306537002574 arginine repressor; Provisional; Region: PRK03341 306537002575 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 306537002576 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 306537002577 argininosuccinate synthase; Provisional; Region: PRK13820 306537002578 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 306537002579 ANP binding site [chemical binding]; other site 306537002580 Substrate Binding Site II [chemical binding]; other site 306537002581 Substrate Binding Site I [chemical binding]; other site 306537002582 argininosuccinate lyase; Provisional; Region: PRK00855 306537002583 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 306537002584 active sites [active] 306537002585 tetramer interface [polypeptide binding]; other site 306537002586 thiamine biosynthesis protein ThiF; Validated; Region: PRK05600 306537002587 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 306537002588 ATP binding site [chemical binding]; other site 306537002589 substrate interface [chemical binding]; other site 306537002590 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 306537002591 active site residue [active] 306537002592 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 306537002593 ThiS interaction site; other site 306537002594 putative active site [active] 306537002595 tetramer interface [polypeptide binding]; other site 306537002596 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 306537002597 thiS-thiF/thiG interaction site; other site 306537002598 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 306537002599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306537002600 Major Facilitator Superfamily; Region: MFS_1; pfam07690 306537002601 putative substrate translocation pore; other site 306537002602 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 306537002603 active site 306537002604 thiamine phosphate binding site [chemical binding]; other site 306537002605 pyrophosphate binding site [ion binding]; other site 306537002606 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 306537002607 ThiC-associated domain; Region: ThiC-associated; pfam13667 306537002608 ThiC family; Region: ThiC; pfam01964 306537002609 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 306537002610 metal ion-dependent adhesion site (MIDAS); other site 306537002611 von Willebrand factor type A domain; Region: VWA_2; pfam13519 306537002612 Uncharacterized conserved protein [Function unknown]; Region: COG2835 306537002613 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 306537002614 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 306537002615 active site 306537002616 HIGH motif; other site 306537002617 dimer interface [polypeptide binding]; other site 306537002618 KMSKS motif; other site 306537002619 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 306537002620 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 306537002621 motif I; other site 306537002622 motif II; other site 306537002623 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 306537002624 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 306537002625 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 306537002626 RNA binding surface [nucleotide binding]; other site 306537002627 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 306537002628 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 306537002629 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 306537002630 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 306537002631 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 306537002632 Walker A/P-loop; other site 306537002633 ATP binding site [chemical binding]; other site 306537002634 Q-loop/lid; other site 306537002635 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 306537002636 ABC transporter signature motif; other site 306537002637 Walker B; other site 306537002638 D-loop; other site 306537002639 H-loop/switch region; other site 306537002640 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 306537002641 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 306537002642 Thiamine pyrophosphokinase; Region: TPK; cl08415 306537002643 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 306537002644 CTP synthetase; Validated; Region: pyrG; PRK05380 306537002645 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 306537002646 Catalytic site [active] 306537002647 active site 306537002648 UTP binding site [chemical binding]; other site 306537002649 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 306537002650 active site 306537002651 putative oxyanion hole; other site 306537002652 catalytic triad [active] 306537002653 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 306537002654 dimer interface [polypeptide binding]; other site 306537002655 ADP-ribose binding site [chemical binding]; other site 306537002656 active site 306537002657 nudix motif; other site 306537002658 metal binding site [ion binding]; metal-binding site 306537002659 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 306537002660 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 306537002661 active site 306537002662 DNA binding site [nucleotide binding] 306537002663 Int/Topo IB signature motif; other site 306537002664 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 306537002665 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 306537002666 P-loop; other site 306537002667 Magnesium ion binding site [ion binding]; other site 306537002668 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 306537002669 Magnesium ion binding site [ion binding]; other site 306537002670 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 306537002671 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 306537002672 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 306537002673 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 306537002674 RNA binding surface [nucleotide binding]; other site 306537002675 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 306537002676 active site 306537002677 bifunctional cytidylate kinase/GTPase Der; Reviewed; Region: PRK09518 306537002678 AAA domain; Region: AAA_17; pfam13207 306537002679 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 306537002680 CMP-binding site; other site 306537002681 The sites determining sugar specificity; other site 306537002682 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 306537002683 G1 box; other site 306537002684 GTP/Mg2+ binding site [chemical binding]; other site 306537002685 Switch I region; other site 306537002686 G2 box; other site 306537002687 Switch II region; other site 306537002688 G3 box; other site 306537002689 G4 box; other site 306537002690 G5 box; other site 306537002691 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 306537002692 G1 box; other site 306537002693 GTP/Mg2+ binding site [chemical binding]; other site 306537002694 Switch I region; other site 306537002695 G2 box; other site 306537002696 G3 box; other site 306537002697 Switch II region; other site 306537002698 G4 box; other site 306537002699 G5 box; other site 306537002700 Transposase; Region: DEDD_Tnp_IS110; pfam01548 306537002701 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 306537002702 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 306537002703 Haemolysin-III related; Region: HlyIII; pfam03006 306537002704 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 306537002705 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 306537002706 Potassium binding sites [ion binding]; other site 306537002707 Cesium cation binding sites [ion binding]; other site 306537002708 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 306537002709 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 306537002710 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 306537002711 Predicted permease [General function prediction only]; Region: COG2985 306537002712 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 306537002713 TrkA-C domain; Region: TrkA_C; pfam02080 306537002714 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 306537002715 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 306537002716 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 306537002717 catalytic residues [active] 306537002718 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 306537002719 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 306537002720 active site 306537002721 catalytic site [active] 306537002722 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 306537002723 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 306537002724 active site 306537002725 phosphorylation site [posttranslational modification] 306537002726 intermolecular recognition site; other site 306537002727 dimerization interface [polypeptide binding]; other site 306537002728 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 306537002729 DNA binding residues [nucleotide binding] 306537002730 dimerization interface [polypeptide binding]; other site 306537002731 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 306537002732 Histidine kinase; Region: HisKA_3; pfam07730 306537002733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 306537002734 ATP binding site [chemical binding]; other site 306537002735 Mg2+ binding site [ion binding]; other site 306537002736 G-X-G motif; other site 306537002737 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 306537002738 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306537002739 Walker A/P-loop; other site 306537002740 ATP binding site [chemical binding]; other site 306537002741 Q-loop/lid; other site 306537002742 ABC transporter signature motif; other site 306537002743 Walker B; other site 306537002744 D-loop; other site 306537002745 H-loop/switch region; other site 306537002746 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 306537002747 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 306537002748 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 306537002749 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 306537002750 TrkA-N domain; Region: TrkA_N; pfam02254 306537002751 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 306537002752 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 306537002753 Uncharacterized conserved protein [Function unknown]; Region: COG1479 306537002754 Protein of unknown function DUF262; Region: DUF262; pfam03235 306537002755 Protein of unknown function DUF262; Region: DUF262; pfam03235 306537002756 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 306537002757 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 306537002758 HsdM N-terminal domain; Region: HsdM_N; pfam12161 306537002759 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306537002760 S-adenosylmethionine binding site [chemical binding]; other site 306537002761 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 306537002762 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 306537002763 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 306537002764 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 306537002765 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 306537002766 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 306537002767 ATP binding site [chemical binding]; other site 306537002768 putative Mg++ binding site [ion binding]; other site 306537002769 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 306537002770 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 306537002771 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 306537002772 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 306537002773 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 306537002774 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 306537002775 phosphopeptide binding site; other site 306537002776 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 306537002777 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 306537002778 DNA binding residues [nucleotide binding] 306537002779 Bifunctional nuclease; Region: DNase-RNase; cl00553 306537002780 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 306537002781 DNA binding residues [nucleotide binding] 306537002782 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 306537002783 putative dimer interface [polypeptide binding]; other site 306537002784 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 306537002785 Domain of unknown function DUF21; Region: DUF21; pfam01595 306537002786 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 306537002787 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 306537002788 Domain of unknown function DUF21; Region: DUF21; pfam01595 306537002789 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 306537002790 Transporter associated domain; Region: CorC_HlyC; smart01091 306537002791 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 306537002792 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 306537002793 ATP binding site [chemical binding]; other site 306537002794 putative Mg++ binding site [ion binding]; other site 306537002795 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 306537002796 nucleotide binding region [chemical binding]; other site 306537002797 ATP-binding site [chemical binding]; other site 306537002798 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 306537002799 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 306537002800 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 306537002801 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 306537002802 CoenzymeA binding site [chemical binding]; other site 306537002803 subunit interaction site [polypeptide binding]; other site 306537002804 PHB binding site; other site 306537002805 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 306537002806 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 306537002807 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 306537002808 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 306537002809 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 306537002810 FAD binding domain; Region: FAD_binding_2; pfam00890 306537002811 Amidase; Region: Amidase; cl11426 306537002812 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 306537002813 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306537002814 NAD(P) binding site [chemical binding]; other site 306537002815 active site 306537002816 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 306537002817 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 306537002818 ATP-grasp domain; Region: ATP-grasp_4; cl17255 306537002819 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 306537002820 Cytochrome P450; Region: p450; cl12078 306537002821 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 306537002822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306537002823 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 306537002824 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 306537002825 non-specific DNA binding site [nucleotide binding]; other site 306537002826 salt bridge; other site 306537002827 sequence-specific DNA binding site [nucleotide binding]; other site 306537002828 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 306537002829 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 306537002830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306537002831 putative substrate translocation pore; other site 306537002832 Major Facilitator Superfamily; Region: MFS_1; pfam07690 306537002833 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 306537002834 beta-galactosidase; Region: BGL; TIGR03356 306537002835 Secretory lipase; Region: LIP; pfam03583 306537002836 YceI-like domain; Region: YceI; pfam04264 306537002837 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 306537002838 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 306537002839 Ligand binding site; other site 306537002840 Putative Catalytic site; other site 306537002841 DXD motif; other site 306537002842 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 306537002843 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 306537002844 putative active site [active] 306537002845 catalytic triad [active] 306537002846 putative dimer interface [polypeptide binding]; other site 306537002847 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 306537002848 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 306537002849 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306537002850 NAD(P) binding site [chemical binding]; other site 306537002851 active site 306537002852 DEAD-like helicases superfamily; Region: DEXDc; smart00487 306537002853 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 306537002854 ATP binding site [chemical binding]; other site 306537002855 putative Mg++ binding site [ion binding]; other site 306537002856 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 306537002857 nucleotide binding region [chemical binding]; other site 306537002858 ATP-binding site [chemical binding]; other site 306537002859 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 306537002860 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 306537002861 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 306537002862 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 306537002863 WYL domain; Region: WYL; pfam13280 306537002864 WYL domain; Region: WYL; pfam13280 306537002865 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 306537002866 Pup-like protein; Region: Pup; pfam05639 306537002867 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 306537002868 proteasome ATPase; Region: pup_AAA; TIGR03689 306537002869 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306537002870 Walker A motif; other site 306537002871 ATP binding site [chemical binding]; other site 306537002872 Walker B motif; other site 306537002873 arginine finger; other site 306537002874 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 306537002875 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306537002876 S-adenosylmethionine binding site [chemical binding]; other site 306537002877 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 306537002878 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 306537002879 Aspartase; Region: Aspartase; cd01357 306537002880 active sites [active] 306537002881 tetramer interface [polypeptide binding]; other site 306537002882 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 306537002883 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 306537002884 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 306537002885 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 306537002886 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 306537002887 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 306537002888 motif II; other site 306537002889 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 306537002890 homodimer interface [polypeptide binding]; other site 306537002891 putative metal binding site [ion binding]; other site 306537002892 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 306537002893 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 306537002894 CoenzymeA binding site [chemical binding]; other site 306537002895 subunit interaction site [polypeptide binding]; other site 306537002896 PHB binding site; other site 306537002897 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 306537002898 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 306537002899 active site 306537002900 HIGH motif; other site 306537002901 nucleotide binding site [chemical binding]; other site 306537002902 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 306537002903 active site 306537002904 KMSKS motif; other site 306537002905 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 306537002906 tRNA binding surface [nucleotide binding]; other site 306537002907 anticodon binding site; other site 306537002908 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 306537002909 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 306537002910 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 306537002911 quinone interaction residues [chemical binding]; other site 306537002912 active site 306537002913 catalytic residues [active] 306537002914 FMN binding site [chemical binding]; other site 306537002915 substrate binding site [chemical binding]; other site 306537002916 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 306537002917 substrate binding site [chemical binding]; other site 306537002918 Uncharacterized conserved protein [Function unknown]; Region: COG0398 306537002919 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 306537002920 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 306537002921 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 306537002922 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 306537002923 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 306537002924 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 306537002925 NlpC/P60 family; Region: NLPC_P60; pfam00877 306537002926 aconitate hydratase; Validated; Region: PRK09277 306537002927 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 306537002928 substrate binding site [chemical binding]; other site 306537002929 ligand binding site [chemical binding]; other site 306537002930 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 306537002931 substrate binding site [chemical binding]; other site 306537002932 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 306537002933 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 306537002934 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 306537002935 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 306537002936 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 306537002937 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 306537002938 putative DNA binding site [nucleotide binding]; other site 306537002939 putative Zn2+ binding site [ion binding]; other site 306537002940 AsnC family; Region: AsnC_trans_reg; pfam01037 306537002941 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 306537002942 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 306537002943 dimer interface [polypeptide binding]; other site 306537002944 PYR/PP interface [polypeptide binding]; other site 306537002945 TPP binding site [chemical binding]; other site 306537002946 substrate binding site [chemical binding]; other site 306537002947 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 306537002948 TPP-binding site; other site 306537002949 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 306537002950 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 306537002951 catalytic triad [active] 306537002952 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 306537002953 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306537002954 Walker A/P-loop; other site 306537002955 ATP binding site [chemical binding]; other site 306537002956 Q-loop/lid; other site 306537002957 ABC transporter signature motif; other site 306537002958 Walker B; other site 306537002959 D-loop; other site 306537002960 H-loop/switch region; other site 306537002961 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 306537002962 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 306537002963 lycopene cyclase; Region: lycopene_cycl; TIGR01789 306537002964 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 306537002965 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 306537002966 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 306537002967 trimerization site [polypeptide binding]; other site 306537002968 active site 306537002969 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 306537002970 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 306537002971 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 306537002972 catalytic residue [active] 306537002973 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 306537002974 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 306537002975 Walker A/P-loop; other site 306537002976 ATP binding site [chemical binding]; other site 306537002977 Q-loop/lid; other site 306537002978 ABC transporter signature motif; other site 306537002979 Walker B; other site 306537002980 D-loop; other site 306537002981 H-loop/switch region; other site 306537002982 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 306537002983 FeS assembly protein SufD; Region: sufD; TIGR01981 306537002984 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 306537002985 FeS assembly protein SufB; Region: sufB; TIGR01980 306537002986 Predicted transcriptional regulator [Transcription]; Region: COG2345 306537002987 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 306537002988 dimerization interface [polypeptide binding]; other site 306537002989 putative DNA binding site [nucleotide binding]; other site 306537002990 putative Zn2+ binding site [ion binding]; other site 306537002991 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 306537002992 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 306537002993 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 306537002994 Walker A/P-loop; other site 306537002995 ATP binding site [chemical binding]; other site 306537002996 Q-loop/lid; other site 306537002997 ABC transporter signature motif; other site 306537002998 Walker B; other site 306537002999 D-loop; other site 306537003000 H-loop/switch region; other site 306537003001 ABC-2 type transporter; Region: ABC2_membrane; cl17235 306537003002 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 306537003003 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 306537003004 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 306537003005 UbiA prenyltransferase family; Region: UbiA; pfam01040 306537003006 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 306537003007 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 306537003008 TPP-binding site [chemical binding]; other site 306537003009 dimer interface [polypeptide binding]; other site 306537003010 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 306537003011 PYR/PP interface [polypeptide binding]; other site 306537003012 dimer interface [polypeptide binding]; other site 306537003013 TPP binding site [chemical binding]; other site 306537003014 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 306537003015 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 306537003016 putative active site [active] 306537003017 transaldolase; Provisional; Region: PRK03903 306537003018 catalytic residue [active] 306537003019 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 306537003020 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 306537003021 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 306537003022 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 306537003023 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 306537003024 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 306537003025 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 306537003026 putative active site [active] 306537003027 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 306537003028 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 306537003029 triosephosphate isomerase; Provisional; Region: PRK14567 306537003030 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 306537003031 substrate binding site [chemical binding]; other site 306537003032 dimer interface [polypeptide binding]; other site 306537003033 catalytic triad [active] 306537003034 Phosphoglycerate kinase; Region: PGK; pfam00162 306537003035 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 306537003036 substrate binding site [chemical binding]; other site 306537003037 hinge regions; other site 306537003038 ADP binding site [chemical binding]; other site 306537003039 catalytic site [active] 306537003040 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 306537003041 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 306537003042 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 306537003043 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 306537003044 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 306537003045 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 306537003046 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 306537003047 phosphate binding site [ion binding]; other site 306537003048 putative substrate binding pocket [chemical binding]; other site 306537003049 dimer interface [polypeptide binding]; other site 306537003050 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 306537003051 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 306537003052 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 306537003053 GIY-YIG motif/motif A; other site 306537003054 active site 306537003055 catalytic site [active] 306537003056 putative DNA binding site [nucleotide binding]; other site 306537003057 metal binding site [ion binding]; metal-binding site 306537003058 UvrB/uvrC motif; Region: UVR; pfam02151 306537003059 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 306537003060 Helix-hairpin-helix motif; Region: HHH; pfam00633 306537003061 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 306537003062 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 306537003063 homopentamer interface [polypeptide binding]; other site 306537003064 active site 306537003065 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 306537003066 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 306537003067 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 306537003068 dimerization interface [polypeptide binding]; other site 306537003069 active site 306537003070 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 306537003071 Lumazine binding domain; Region: Lum_binding; pfam00677 306537003072 Lumazine binding domain; Region: Lum_binding; pfam00677 306537003073 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 306537003074 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 306537003075 catalytic motif [active] 306537003076 Zn binding site [ion binding]; other site 306537003077 RibD C-terminal domain; Region: RibD_C; pfam01872 306537003078 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 306537003079 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 306537003080 substrate binding site [chemical binding]; other site 306537003081 hexamer interface [polypeptide binding]; other site 306537003082 metal binding site [ion binding]; metal-binding site 306537003083 16S rRNA methyltransferase B; Provisional; Region: PRK14902 306537003084 NusB family; Region: NusB; pfam01029 306537003085 putative RNA binding site [nucleotide binding]; other site 306537003086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306537003087 S-adenosylmethionine binding site [chemical binding]; other site 306537003088 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 306537003089 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 306537003090 putative active site [active] 306537003091 substrate binding site [chemical binding]; other site 306537003092 putative cosubstrate binding site; other site 306537003093 catalytic site [active] 306537003094 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 306537003095 substrate binding site [chemical binding]; other site 306537003096 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 306537003097 active site 306537003098 catalytic residues [active] 306537003099 metal binding site [ion binding]; metal-binding site 306537003100 primosome assembly protein PriA; Provisional; Region: PRK14873 306537003101 S-adenosylmethionine synthetase; Validated; Region: PRK05250 306537003102 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 306537003103 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 306537003104 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 306537003105 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 306537003106 Flavoprotein; Region: Flavoprotein; pfam02441 306537003107 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 306537003108 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 306537003109 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 306537003110 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 306537003111 catalytic site [active] 306537003112 G-X2-G-X-G-K; other site 306537003113 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 306537003114 active site 306537003115 dimer interface [polypeptide binding]; other site 306537003116 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 306537003117 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 306537003118 ATP-grasp domain; Region: ATP-grasp_4; cl17255 306537003119 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 306537003120 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 306537003121 ATP-grasp domain; Region: ATP-grasp_4; cl17255 306537003122 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 306537003123 IMP binding site; other site 306537003124 dimer interface [polypeptide binding]; other site 306537003125 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 306537003126 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 306537003127 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 306537003128 catalytic site [active] 306537003129 subunit interface [polypeptide binding]; other site 306537003130 dihydroorotase; Validated; Region: pyrC; PRK09357 306537003131 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 306537003132 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 306537003133 active site 306537003134 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 306537003135 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 306537003136 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 306537003137 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 306537003138 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 306537003139 active site 306537003140 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 306537003141 putative RNA binding site [nucleotide binding]; other site 306537003142 elongation factor P; Validated; Region: PRK00529 306537003143 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 306537003144 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 306537003145 RNA binding site [nucleotide binding]; other site 306537003146 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 306537003147 RNA binding site [nucleotide binding]; other site 306537003148 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 306537003149 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 306537003150 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 306537003151 active site 306537003152 Dehydroquinase class II; Region: DHquinase_II; pfam01220 306537003153 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 306537003154 trimer interface [polypeptide binding]; other site 306537003155 active site 306537003156 dimer interface [polypeptide binding]; other site 306537003157 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 306537003158 active site 306537003159 dimer interface [polypeptide binding]; other site 306537003160 metal binding site [ion binding]; metal-binding site 306537003161 shikimate kinase; Reviewed; Region: aroK; PRK00131 306537003162 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 306537003163 ADP binding site [chemical binding]; other site 306537003164 magnesium binding site [ion binding]; other site 306537003165 putative shikimate binding site; other site 306537003166 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 306537003167 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 306537003168 Tetramer interface [polypeptide binding]; other site 306537003169 active site 306537003170 FMN-binding site [chemical binding]; other site 306537003171 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 306537003172 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 306537003173 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 306537003174 shikimate binding site; other site 306537003175 NAD(P) binding site [chemical binding]; other site 306537003176 YceG-like family; Region: YceG; pfam02618 306537003177 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 306537003178 dimerization interface [polypeptide binding]; other site 306537003179 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 306537003180 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 306537003181 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 306537003182 motif 1; other site 306537003183 active site 306537003184 motif 2; other site 306537003185 motif 3; other site 306537003186 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 306537003187 DHHA1 domain; Region: DHHA1; pfam02272 306537003188 recombination factor protein RarA; Reviewed; Region: PRK13342 306537003189 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306537003190 Walker A motif; other site 306537003191 ATP binding site [chemical binding]; other site 306537003192 Walker B motif; other site 306537003193 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 306537003194 Phosphotransferase enzyme family; Region: APH; pfam01636 306537003195 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 306537003196 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 306537003197 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 306537003198 dimer interface [polypeptide binding]; other site 306537003199 anticodon binding site; other site 306537003200 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 306537003201 homodimer interface [polypeptide binding]; other site 306537003202 motif 1; other site 306537003203 active site 306537003204 motif 2; other site 306537003205 GAD domain; Region: GAD; pfam02938 306537003206 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 306537003207 active site 306537003208 motif 3; other site 306537003209 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 306537003210 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 306537003211 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 306537003212 generic binding surface II; other site 306537003213 generic binding surface I; other site 306537003214 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 306537003215 putative active site [active] 306537003216 putative catalytic site [active] 306537003217 putative Mg binding site IVb [ion binding]; other site 306537003218 putative phosphate binding site [ion binding]; other site 306537003219 putative DNA binding site [nucleotide binding]; other site 306537003220 putative Mg binding site IVa [ion binding]; other site 306537003221 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 306537003222 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 306537003223 putative active site [active] 306537003224 putative metal binding site [ion binding]; other site 306537003225 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 306537003226 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 306537003227 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 306537003228 dimer interface [polypeptide binding]; other site 306537003229 motif 1; other site 306537003230 active site 306537003231 motif 2; other site 306537003232 motif 3; other site 306537003233 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 306537003234 anticodon binding site; other site 306537003235 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 306537003236 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 306537003237 active site 306537003238 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 306537003239 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 306537003240 Zn2+ binding site [ion binding]; other site 306537003241 Mg2+ binding site [ion binding]; other site 306537003242 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 306537003243 synthetase active site [active] 306537003244 NTP binding site [chemical binding]; other site 306537003245 metal binding site [ion binding]; metal-binding site 306537003246 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 306537003247 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 306537003248 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 306537003249 active site 306537003250 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 306537003251 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 306537003252 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 306537003253 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 306537003254 Protein export membrane protein; Region: SecD_SecF; pfam02355 306537003255 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 306537003256 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 306537003257 Preprotein translocase subunit; Region: YajC; pfam02699 306537003258 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 306537003259 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306537003260 Walker A motif; other site 306537003261 ATP binding site [chemical binding]; other site 306537003262 Walker B motif; other site 306537003263 arginine finger; other site 306537003264 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 306537003265 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 306537003266 RuvA N terminal domain; Region: RuvA_N; pfam01330 306537003267 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 306537003268 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 306537003269 active site 306537003270 putative DNA-binding cleft [nucleotide binding]; other site 306537003271 dimer interface [polypeptide binding]; other site 306537003272 hypothetical protein; Validated; Region: PRK00110 306537003273 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 306537003274 predicted active site [active] 306537003275 catalytic triad [active] 306537003276 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 306537003277 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 306537003278 active site 306537003279 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 306537003280 catalytic triad [active] 306537003281 dimer interface [polypeptide binding]; other site 306537003282 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 306537003283 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 306537003284 active site 306537003285 multimer interface [polypeptide binding]; other site 306537003286 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 306537003287 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 306537003288 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 306537003289 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 306537003290 putative acyl-acceptor binding pocket; other site 306537003291 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 306537003292 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 306537003293 nucleotide binding site/active site [active] 306537003294 HIT family signature motif; other site 306537003295 catalytic residue [active] 306537003296 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 306537003297 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 306537003298 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 306537003299 active site 306537003300 dimer interface [polypeptide binding]; other site 306537003301 motif 1; other site 306537003302 motif 2; other site 306537003303 motif 3; other site 306537003304 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 306537003305 anticodon binding site; other site 306537003306 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 306537003307 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 306537003308 Protein of unknown function (DUF461); Region: DUF461; pfam04314 306537003309 CopC domain; Region: CopC; pfam04234 306537003310 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 306537003311 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 306537003312 SelR domain; Region: SelR; pfam01641 306537003313 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 306537003314 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 306537003315 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 306537003316 substrate binding site [chemical binding]; other site 306537003317 active site 306537003318 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 306537003319 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 306537003320 catalytic site [active] 306537003321 putative active site [active] 306537003322 putative substrate binding site [chemical binding]; other site 306537003323 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 306537003324 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 306537003325 TPP-binding site; other site 306537003326 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 306537003327 PYR/PP interface [polypeptide binding]; other site 306537003328 dimer interface [polypeptide binding]; other site 306537003329 TPP binding site [chemical binding]; other site 306537003330 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 306537003331 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 306537003332 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306537003333 S-adenosylmethionine binding site [chemical binding]; other site 306537003334 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 306537003335 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 306537003336 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 306537003337 trimer interface [polypeptide binding]; other site 306537003338 active site 306537003339 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 306537003340 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 306537003341 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 306537003342 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 306537003343 active site 306537003344 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 306537003345 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 306537003346 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 306537003347 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 306537003348 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 306537003349 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 306537003350 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 306537003351 DNA binding residues [nucleotide binding] 306537003352 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 306537003353 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 306537003354 ATP binding site [chemical binding]; other site 306537003355 putative Mg++ binding site [ion binding]; other site 306537003356 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 306537003357 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 306537003358 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 306537003359 D-tyrosyl-tRNA(Tyr) deacylase; Provisional; Region: PRK05273 306537003360 putative active site [active] 306537003361 dimerization interface [polypeptide binding]; other site 306537003362 putative tRNAtyr binding site [nucleotide binding]; other site 306537003363 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 306537003364 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 306537003365 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 306537003366 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 306537003367 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 306537003368 DNA binding residues [nucleotide binding] 306537003369 MULE transposase domain; Region: MULE; pfam10551 306537003370 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 306537003371 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 306537003372 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 306537003373 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 306537003374 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 306537003375 NAD binding site [chemical binding]; other site 306537003376 homodimer interface [polypeptide binding]; other site 306537003377 active site 306537003378 substrate binding site [chemical binding]; other site 306537003379 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 306537003380 PAC2 family; Region: PAC2; pfam09754 306537003381 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 306537003382 ATP binding site [chemical binding]; other site 306537003383 putative Mg++ binding site [ion binding]; other site 306537003384 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 306537003385 nucleotide binding region [chemical binding]; other site 306537003386 ATP-binding site [chemical binding]; other site 306537003387 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 306537003388 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 306537003389 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 306537003390 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 306537003391 dimerization interface [polypeptide binding]; other site 306537003392 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 306537003393 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 306537003394 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 306537003395 ATP binding site [chemical binding]; other site 306537003396 putative Mg++ binding site [ion binding]; other site 306537003397 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 306537003398 nucleotide binding region [chemical binding]; other site 306537003399 ATP-binding site [chemical binding]; other site 306537003400 Helicase associated domain (HA2); Region: HA2; pfam04408 306537003401 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 306537003402 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 306537003403 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 306537003404 ATP cone domain; Region: ATP-cone; pfam03477 306537003405 LexA repressor; Validated; Region: PRK00215 306537003406 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 306537003407 putative DNA binding site [nucleotide binding]; other site 306537003408 putative Zn2+ binding site [ion binding]; other site 306537003409 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 306537003410 Catalytic site [active] 306537003411 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 306537003412 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 306537003413 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 306537003414 GTPases [General function prediction only]; Region: HflX; COG2262 306537003415 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 306537003416 HflX GTPase family; Region: HflX; cd01878 306537003417 G1 box; other site 306537003418 GTP/Mg2+ binding site [chemical binding]; other site 306537003419 Switch I region; other site 306537003420 G2 box; other site 306537003421 G3 box; other site 306537003422 Switch II region; other site 306537003423 G4 box; other site 306537003424 G5 box; other site 306537003425 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 306537003426 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 306537003427 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 306537003428 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 306537003429 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 306537003430 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 306537003431 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 306537003432 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 306537003433 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 306537003434 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 306537003435 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 306537003436 FeS/SAM binding site; other site 306537003437 TRAM domain; Region: TRAM; cl01282 306537003438 recombination regulator RecX; Reviewed; Region: recX; PRK00117 306537003439 recombinase A; Provisional; Region: recA; PRK09354 306537003440 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 306537003441 hexamer interface [polypeptide binding]; other site 306537003442 Walker A motif; other site 306537003443 ATP binding site [chemical binding]; other site 306537003444 Walker B motif; other site 306537003445 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 306537003446 BioY family; Region: BioY; pfam02632 306537003447 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 306537003448 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 306537003449 Walker A/P-loop; other site 306537003450 ATP binding site [chemical binding]; other site 306537003451 Q-loop/lid; other site 306537003452 ABC transporter signature motif; other site 306537003453 Walker B; other site 306537003454 D-loop; other site 306537003455 H-loop/switch region; other site 306537003456 Cobalt transport protein; Region: CbiQ; cl00463 306537003457 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 306537003458 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 306537003459 non-specific DNA binding site [nucleotide binding]; other site 306537003460 salt bridge; other site 306537003461 sequence-specific DNA binding site [nucleotide binding]; other site 306537003462 Competence-damaged protein; Region: CinA; pfam02464 306537003463 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 306537003464 Integral membrane protein TerC family; Region: TerC; cl10468 306537003465 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 306537003466 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 306537003467 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 306537003468 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 306537003469 TIGR03085 family protein; Region: TIGR03085 306537003470 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 306537003471 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 306537003472 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 306537003473 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 306537003474 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 306537003475 dimer interface [polypeptide binding]; other site 306537003476 active site 306537003477 catalytic residue [active] 306537003478 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 306537003479 dihydrodipicolinate reductase; Provisional; Region: PRK00048 306537003480 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 306537003481 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 306537003482 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 306537003483 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 306537003484 oligomer interface [polypeptide binding]; other site 306537003485 RNA binding site [nucleotide binding]; other site 306537003486 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 306537003487 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 306537003488 RNase E interface [polypeptide binding]; other site 306537003489 trimer interface [polypeptide binding]; other site 306537003490 active site 306537003491 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 306537003492 putative nucleic acid binding region [nucleotide binding]; other site 306537003493 G-X-X-G motif; other site 306537003494 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 306537003495 RNA binding site [nucleotide binding]; other site 306537003496 domain interface; other site 306537003497 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 306537003498 Helix-turn-helix domain; Region: HTH_28; pfam13518 306537003499 HTH-like domain; Region: HTH_21; pfam13276 306537003500 Integrase core domain; Region: rve; pfam00665 306537003501 Integrase core domain; Region: rve_2; pfam13333 306537003502 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 306537003503 16S/18S rRNA binding site [nucleotide binding]; other site 306537003504 S13e-L30e interaction site [polypeptide binding]; other site 306537003505 25S rRNA binding site [nucleotide binding]; other site 306537003506 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 306537003507 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 306537003508 active site 306537003509 Riboflavin kinase; Region: Flavokinase; smart00904 306537003510 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 306537003511 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 306537003512 RNA binding site [nucleotide binding]; other site 306537003513 active site 306537003514 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 306537003515 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 306537003516 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 306537003517 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 306537003518 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 306537003519 active site 306537003520 metal binding site [ion binding]; metal-binding site 306537003521 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 306537003522 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 306537003523 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 306537003524 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 306537003525 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 306537003526 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 306537003527 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 306537003528 G1 box; other site 306537003529 putative GEF interaction site [polypeptide binding]; other site 306537003530 GTP/Mg2+ binding site [chemical binding]; other site 306537003531 Switch I region; other site 306537003532 G2 box; other site 306537003533 G3 box; other site 306537003534 Switch II region; other site 306537003535 G4 box; other site 306537003536 G5 box; other site 306537003537 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 306537003538 Translation-initiation factor 2; Region: IF-2; pfam11987 306537003539 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 306537003540 Protein of unknown function (DUF448); Region: DUF448; pfam04296 306537003541 putative RNA binding cleft [nucleotide binding]; other site 306537003542 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 306537003543 NusA N-terminal domain; Region: NusA_N; pfam08529 306537003544 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 306537003545 RNA binding site [nucleotide binding]; other site 306537003546 homodimer interface [polypeptide binding]; other site 306537003547 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 306537003548 G-X-X-G motif; other site 306537003549 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 306537003550 G-X-X-G motif; other site 306537003551 ribosome maturation protein RimP; Reviewed; Region: PRK00092 306537003552 Sm and related proteins; Region: Sm_like; cl00259 306537003553 heptamer interface [polypeptide binding]; other site 306537003554 Sm1 motif; other site 306537003555 hexamer interface [polypeptide binding]; other site 306537003556 RNA binding site [nucleotide binding]; other site 306537003557 Sm2 motif; other site 306537003558 prolyl-tRNA synthetase; Provisional; Region: PRK09194 306537003559 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 306537003560 dimer interface [polypeptide binding]; other site 306537003561 motif 1; other site 306537003562 active site 306537003563 motif 2; other site 306537003564 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 306537003565 putative deacylase active site [active] 306537003566 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 306537003567 active site 306537003568 motif 3; other site 306537003569 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 306537003570 anticodon binding site; other site 306537003571 hypothetical protein; Validated; Region: PRK02101 306537003572 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 306537003573 active site 306537003574 SAM binding site [chemical binding]; other site 306537003575 homodimer interface [polypeptide binding]; other site 306537003576 Uncharacterized conserved protein [Function unknown]; Region: COG0397 306537003577 hypothetical protein; Validated; Region: PRK00029 306537003578 malate:quinone oxidoreductase; Validated; Region: PRK05257 306537003579 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 306537003580 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 306537003581 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 306537003582 mycothione reductase; Region: mycothione_red; TIGR03452 306537003583 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 306537003584 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 306537003585 short chain dehydrogenase; Provisional; Region: PRK07832 306537003586 classical (c) SDRs; Region: SDR_c; cd05233 306537003587 NAD(P) binding site [chemical binding]; other site 306537003588 active site 306537003589 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 306537003590 Predicted membrane protein [General function prediction only]; Region: COG4194 306537003591 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 306537003592 DNA-binding site [nucleotide binding]; DNA binding site 306537003593 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 306537003594 active site 306537003595 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 306537003596 Uncharacterized conserved protein [Function unknown]; Region: COG2128 306537003597 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 306537003598 active site 306537003599 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 306537003600 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 306537003601 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 306537003602 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 306537003603 active site 306537003604 phosphorylation site [posttranslational modification] 306537003605 intermolecular recognition site; other site 306537003606 dimerization interface [polypeptide binding]; other site 306537003607 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 306537003608 DNA binding residues [nucleotide binding] 306537003609 dimerization interface [polypeptide binding]; other site 306537003610 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 306537003611 Histidine kinase; Region: HisKA_3; pfam07730 306537003612 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 306537003613 ATP binding site [chemical binding]; other site 306537003614 Mg2+ binding site [ion binding]; other site 306537003615 G-X-G motif; other site 306537003616 FtsX-like permease family; Region: FtsX; pfam02687 306537003617 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 306537003618 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 306537003619 Walker A/P-loop; other site 306537003620 ATP binding site [chemical binding]; other site 306537003621 Q-loop/lid; other site 306537003622 ABC transporter signature motif; other site 306537003623 Walker B; other site 306537003624 D-loop; other site 306537003625 H-loop/switch region; other site 306537003626 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 306537003627 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 306537003628 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 306537003629 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 306537003630 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 306537003631 active site 306537003632 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 306537003633 protein binding site [polypeptide binding]; other site 306537003634 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 306537003635 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 306537003636 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 306537003637 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 306537003638 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 306537003639 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 306537003640 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 306537003641 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 306537003642 FeS/SAM binding site; other site 306537003643 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 306537003644 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 306537003645 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 306537003646 ribosome recycling factor; Reviewed; Region: frr; PRK00083 306537003647 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 306537003648 hinge region; other site 306537003649 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 306537003650 putative nucleotide binding site [chemical binding]; other site 306537003651 uridine monophosphate binding site [chemical binding]; other site 306537003652 homohexameric interface [polypeptide binding]; other site 306537003653 elongation factor Ts; Provisional; Region: tsf; PRK09377 306537003654 UBA/TS-N domain; Region: UBA; pfam00627 306537003655 Elongation factor TS; Region: EF_TS; pfam00889 306537003656 Elongation factor TS; Region: EF_TS; pfam00889 306537003657 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 306537003658 rRNA interaction site [nucleotide binding]; other site 306537003659 S8 interaction site; other site 306537003660 putative laminin-1 binding site; other site 306537003661 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 306537003662 Peptidase family M23; Region: Peptidase_M23; pfam01551 306537003663 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 306537003664 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 306537003665 active site 306537003666 DNA binding site [nucleotide binding] 306537003667 Int/Topo IB signature motif; other site 306537003668 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 306537003669 DNA protecting protein DprA; Region: dprA; TIGR00732 306537003670 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 306537003671 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 306537003672 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306537003673 Walker A motif; other site 306537003674 ATP binding site [chemical binding]; other site 306537003675 Walker B motif; other site 306537003676 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 306537003677 hypothetical protein; Reviewed; Region: PRK12497 306537003678 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 306537003679 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 306537003680 RNA/DNA hybrid binding site [nucleotide binding]; other site 306537003681 active site 306537003682 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 306537003683 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 306537003684 Catalytic site [active] 306537003685 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 306537003686 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 306537003687 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 306537003688 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 306537003689 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 306537003690 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 306537003691 RNA binding site [nucleotide binding]; other site 306537003692 BCCT family transporter; Region: BCCT; cl00569 306537003693 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 306537003694 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 306537003695 NAD(P) binding site [chemical binding]; other site 306537003696 catalytic residues [active] 306537003697 BCCT family transporter; Region: BCCT; cl00569 306537003698 choline dehydrogenase; Validated; Region: PRK02106 306537003699 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 306537003700 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 306537003701 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 306537003702 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 306537003703 RimM N-terminal domain; Region: RimM; pfam01782 306537003704 PRC-barrel domain; Region: PRC; pfam05239 306537003705 glutamate dehydrogenase; Provisional; Region: PRK09414 306537003706 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 306537003707 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 306537003708 NAD(P) binding site [chemical binding]; other site 306537003709 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 306537003710 signal recognition particle protein; Provisional; Region: PRK10867 306537003711 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 306537003712 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 306537003713 P loop; other site 306537003714 GTP binding site [chemical binding]; other site 306537003715 Signal peptide binding domain; Region: SRP_SPB; pfam02978 306537003716 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 306537003717 Nitrogen regulatory protein P-II; Region: P-II; smart00938 306537003718 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 306537003719 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 306537003720 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 306537003721 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 306537003722 Putative esterase; Region: Esterase; pfam00756 306537003723 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 306537003724 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 306537003725 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 306537003726 dimer interface [polypeptide binding]; other site 306537003727 putative anticodon binding site; other site 306537003728 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 306537003729 motif 1; other site 306537003730 dimer interface [polypeptide binding]; other site 306537003731 active site 306537003732 motif 2; other site 306537003733 motif 3; other site 306537003734 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 306537003735 AAA domain; Region: AAA_23; pfam13476 306537003736 Walker A/P-loop; other site 306537003737 ATP binding site [chemical binding]; other site 306537003738 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 306537003739 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 306537003740 ABC transporter signature motif; other site 306537003741 Walker B; other site 306537003742 D-loop; other site 306537003743 H-loop/switch region; other site 306537003744 Predicted membrane protein [Function unknown]; Region: COG2246 306537003745 GtrA-like protein; Region: GtrA; pfam04138 306537003746 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 306537003747 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 306537003748 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 306537003749 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 306537003750 DNA binding site [nucleotide binding] 306537003751 catalytic residue [active] 306537003752 H2TH interface [polypeptide binding]; other site 306537003753 putative catalytic residues [active] 306537003754 turnover-facilitating residue; other site 306537003755 intercalation triad [nucleotide binding]; other site 306537003756 8OG recognition residue [nucleotide binding]; other site 306537003757 putative reading head residues; other site 306537003758 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 306537003759 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 306537003760 ribonuclease III; Reviewed; Region: rnc; PRK00102 306537003761 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 306537003762 dimerization interface [polypeptide binding]; other site 306537003763 active site 306537003764 metal binding site [ion binding]; metal-binding site 306537003765 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 306537003766 dsRNA binding site [nucleotide binding]; other site 306537003767 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 306537003768 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 306537003769 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 306537003770 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 306537003771 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 306537003772 active site 306537003773 (T/H)XGH motif; other site 306537003774 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 306537003775 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306537003776 S-adenosylmethionine binding site [chemical binding]; other site 306537003777 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 306537003778 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 306537003779 carboxyltransferase (CT) interaction site; other site 306537003780 biotinylation site [posttranslational modification]; other site 306537003781 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 306537003782 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 306537003783 generic binding surface II; other site 306537003784 ssDNA binding site; other site 306537003785 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 306537003786 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 306537003787 Walker A motif; other site 306537003788 ATP binding site [chemical binding]; other site 306537003789 ATP binding site [chemical binding]; other site 306537003790 putative Mg++ binding site [ion binding]; other site 306537003791 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 306537003792 nucleotide binding region [chemical binding]; other site 306537003793 ATP-binding site [chemical binding]; other site 306537003794 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 306537003795 DAK2 domain; Region: Dak2; pfam02734 306537003796 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 306537003797 ligand binding site [chemical binding]; other site 306537003798 active site 306537003799 UGI interface [polypeptide binding]; other site 306537003800 catalytic site [active] 306537003801 Thiamine monophosphate kinase [Coenzyme metabolism]; Region: ThiL; COG0611 306537003802 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 306537003803 ATP binding site [chemical binding]; other site 306537003804 dimerization interface [polypeptide binding]; other site 306537003805 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 306537003806 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 306537003807 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 306537003808 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 306537003809 ATP-grasp domain; Region: ATP-grasp_4; cl17255 306537003810 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 306537003811 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 306537003812 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 306537003813 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 306537003814 active site 306537003815 Ap6A binding site [chemical binding]; other site 306537003816 nudix motif; other site 306537003817 metal binding site [ion binding]; metal-binding site 306537003818 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 306537003819 catalytic core [active] 306537003820 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 306537003821 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 306537003822 substrate binding site [chemical binding]; other site 306537003823 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 306537003824 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 306537003825 substrate binding site [chemical binding]; other site 306537003826 ligand binding site [chemical binding]; other site 306537003827 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 306537003828 Transcriptional regulator [Transcription]; Region: IclR; COG1414 306537003829 Bacterial transcriptional regulator; Region: IclR; pfam01614 306537003830 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 306537003831 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 306537003832 Protein of unknown function DUF262; Region: DUF262; pfam03235 306537003833 Uncharacterized conserved protein [Function unknown]; Region: COG1479 306537003834 Protein of unknown function DUF262; Region: DUF262; pfam03235 306537003835 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 306537003836 MULE transposase domain; Region: MULE; pfam10551 306537003837 Transposase; Region: HTH_Tnp_1; cl17663 306537003838 putative transposase OrfB; Reviewed; Region: PHA02517 306537003839 HTH-like domain; Region: HTH_21; pfam13276 306537003840 Integrase core domain; Region: rve; pfam00665 306537003841 Integrase core domain; Region: rve_3; pfam13683 306537003842 Transposase, Mutator family; Region: Transposase_mut; pfam00872 306537003843 MULE transposase domain; Region: MULE; pfam10551 306537003844 Transposase; Region: DEDD_Tnp_IS110; pfam01548 306537003845 putative transposase OrfB; Reviewed; Region: PHA02517 306537003846 HTH-like domain; Region: HTH_21; pfam13276 306537003847 Integrase core domain; Region: rve; pfam00665 306537003848 Integrase core domain; Region: rve_3; pfam13683 306537003849 Transposase; Region: HTH_Tnp_1; cl17663 306537003850 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 306537003851 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 306537003852 HTH-like domain; Region: HTH_21; pfam13276 306537003853 Integrase core domain; Region: rve_3; pfam13683 306537003854 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 306537003855 Mrr N-terminal domain; Region: Mrr_N; pfam14338 306537003856 Restriction endonuclease; Region: Mrr_cat; pfam04471 306537003857 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 306537003858 DNA methylase; Region: N6_N4_Mtase; pfam01555 306537003859 DNA methylase; Region: N6_N4_Mtase; pfam01555 306537003860 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 306537003861 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 306537003862 ATP binding site [chemical binding]; other site 306537003863 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 306537003864 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 306537003865 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 306537003866 active site 306537003867 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 306537003868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306537003869 putative substrate translocation pore; other site 306537003870 POT family; Region: PTR2; cl17359 306537003871 MULE transposase domain; Region: MULE; pfam10551 306537003872 putative transposase OrfB; Reviewed; Region: PHA02517 306537003873 HTH-like domain; Region: HTH_21; pfam13276 306537003874 Integrase core domain; Region: rve; pfam00665 306537003875 Integrase core domain; Region: rve_3; pfam13683 306537003876 Uncharacterized conserved protein [Function unknown]; Region: COG3586 306537003877 putative recombination protein RecB; Provisional; Region: PRK13909 306537003878 AAA ATPase domain; Region: AAA_15; pfam13175 306537003879 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306537003880 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306537003881 Walker A/P-loop; other site 306537003882 Walker A/P-loop; other site 306537003883 ATP binding site [chemical binding]; other site 306537003884 ATP binding site [chemical binding]; other site 306537003885 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 306537003886 putative active site [active] 306537003887 putative metal-binding site [ion binding]; other site 306537003888 Protein of unknown function DUF45; Region: DUF45; pfam01863 306537003889 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 306537003890 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 306537003891 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 306537003892 ATP binding site [chemical binding]; other site 306537003893 putative Mg++ binding site [ion binding]; other site 306537003894 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509 306537003895 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 306537003896 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 306537003897 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 306537003898 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 306537003899 HsdM N-terminal domain; Region: HsdM_N; pfam12161 306537003900 Methyltransferase domain; Region: Methyltransf_26; pfam13659 306537003901 Transposase; Region: DEDD_Tnp_IS110; pfam01548 306537003902 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 306537003903 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 306537003904 HTH-like domain; Region: HTH_21; pfam13276 306537003905 Integrase core domain; Region: rve; pfam00665 306537003906 Transposase, Mutator family; Region: Transposase_mut; pfam00872 306537003907 MULE transposase domain; Region: MULE; pfam10551 306537003908 putative transposase OrfB; Reviewed; Region: PHA02517 306537003909 HTH-like domain; Region: HTH_21; pfam13276 306537003910 Integrase core domain; Region: rve; pfam00665 306537003911 Integrase core domain; Region: rve_3; pfam13683 306537003912 Transposase, Mutator family; Region: Transposase_mut; pfam00872 306537003913 MULE transposase domain; Region: MULE; pfam10551 306537003914 Integrase core domain; Region: rve; pfam00665 306537003915 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 306537003916 Integrase core domain; Region: rve_3; pfam13683 306537003917 Integrase core domain; Region: rve_3; cl15866 306537003918 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 306537003919 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 306537003920 Zn2+ binding site [ion binding]; other site 306537003921 Mg2+ binding site [ion binding]; other site 306537003922 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 306537003923 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 306537003924 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 306537003925 homodimer interface [polypeptide binding]; other site 306537003926 active site pocket [active] 306537003927 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 306537003928 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 306537003929 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 306537003930 Soluble P-type ATPase [General function prediction only]; Region: COG4087 306537003931 K+-transporting ATPase, c chain; Region: KdpC; cl00944 306537003932 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 306537003933 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 306537003934 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 306537003935 Ligand Binding Site [chemical binding]; other site 306537003936 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 306537003937 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 306537003938 dimer interface [polypeptide binding]; other site 306537003939 phosphorylation site [posttranslational modification] 306537003940 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 306537003941 ATP binding site [chemical binding]; other site 306537003942 Mg2+ binding site [ion binding]; other site 306537003943 G-X-G motif; other site 306537003944 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 306537003945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 306537003946 active site 306537003947 phosphorylation site [posttranslational modification] 306537003948 intermolecular recognition site; other site 306537003949 dimerization interface [polypeptide binding]; other site 306537003950 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 306537003951 DNA binding site [nucleotide binding] 306537003952 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 306537003953 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 306537003954 conserved cys residue [active] 306537003955 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 306537003956 Transposase, Mutator family; Region: Transposase_mut; pfam00872 306537003957 MULE transposase domain; Region: MULE; pfam10551 306537003958 MULE transposase domain; Region: MULE; pfam10551 306537003959 MULE transposase domain; Region: MULE; pfam10551 306537003960 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 306537003961 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 306537003962 active site 306537003963 HIGH motif; other site 306537003964 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 306537003965 active site 306537003966 KMSKS motif; other site 306537003967 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 306537003968 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 306537003969 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 306537003970 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 306537003971 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 306537003972 isochorismate synthase DhbC; Validated; Region: PRK06923 306537003973 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 306537003974 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 306537003975 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 306537003976 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 306537003977 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 306537003978 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 306537003979 putative active site [active] 306537003980 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 306537003981 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 306537003982 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 306537003983 tartrate dehydrogenase; Region: TTC; TIGR02089 306537003984 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 306537003985 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 306537003986 Walker A/P-loop; other site 306537003987 ATP binding site [chemical binding]; other site 306537003988 Q-loop/lid; other site 306537003989 ABC transporter signature motif; other site 306537003990 Walker B; other site 306537003991 D-loop; other site 306537003992 H-loop/switch region; other site 306537003993 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 306537003994 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 306537003995 ligand binding site [chemical binding]; other site 306537003996 NAD binding site [chemical binding]; other site 306537003997 dimerization interface [polypeptide binding]; other site 306537003998 catalytic site [active] 306537003999 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 306537004000 putative L-serine binding site [chemical binding]; other site 306537004001 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 306537004002 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 306537004003 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 306537004004 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 306537004005 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 306537004006 Walker A/P-loop; other site 306537004007 ATP binding site [chemical binding]; other site 306537004008 Q-loop/lid; other site 306537004009 ABC transporter signature motif; other site 306537004010 Walker B; other site 306537004011 D-loop; other site 306537004012 H-loop/switch region; other site 306537004013 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 306537004014 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 306537004015 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 306537004016 ABC-ATPase subunit interface; other site 306537004017 dimer interface [polypeptide binding]; other site 306537004018 putative PBP binding regions; other site 306537004019 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 306537004020 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 306537004021 ABC-ATPase subunit interface; other site 306537004022 dimer interface [polypeptide binding]; other site 306537004023 putative PBP binding regions; other site 306537004024 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 306537004025 intersubunit interface [polypeptide binding]; other site 306537004026 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 306537004027 ketol-acid reductoisomerase; Provisional; Region: PRK05479 306537004028 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 306537004029 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 306537004030 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 306537004031 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 306537004032 putative valine binding site [chemical binding]; other site 306537004033 dimer interface [polypeptide binding]; other site 306537004034 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 306537004035 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 306537004036 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 306537004037 PYR/PP interface [polypeptide binding]; other site 306537004038 dimer interface [polypeptide binding]; other site 306537004039 TPP binding site [chemical binding]; other site 306537004040 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 306537004041 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 306537004042 TPP-binding site [chemical binding]; other site 306537004043 dimer interface [polypeptide binding]; other site 306537004044 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 306537004045 Mechanosensitive ion channel; Region: MS_channel; pfam00924 306537004046 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 306537004047 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 306537004048 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306537004049 Walker A/P-loop; other site 306537004050 ATP binding site [chemical binding]; other site 306537004051 Q-loop/lid; other site 306537004052 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306537004053 ABC transporter signature motif; other site 306537004054 Walker B; other site 306537004055 D-loop; other site 306537004056 H-loop/switch region; other site 306537004057 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306537004058 Walker A/P-loop; other site 306537004059 ATP binding site [chemical binding]; other site 306537004060 Q-loop/lid; other site 306537004061 ABC transporter signature motif; other site 306537004062 Walker B; other site 306537004063 D-loop; other site 306537004064 H-loop/switch region; other site 306537004065 Predicted membrane protein [Function unknown]; Region: COG2259 306537004066 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 306537004067 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 306537004068 GatB domain; Region: GatB_Yqey; smart00845 306537004069 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 306537004070 active site 306537004071 6-phosphofructokinase; Provisional; Region: PRK03202 306537004072 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 306537004073 active site 306537004074 ADP/pyrophosphate binding site [chemical binding]; other site 306537004075 dimerization interface [polypeptide binding]; other site 306537004076 allosteric effector site; other site 306537004077 fructose-1,6-bisphosphate binding site; other site 306537004078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306537004079 Major Facilitator Superfamily; Region: MFS_1; pfam07690 306537004080 putative substrate translocation pore; other site 306537004081 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306537004082 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 306537004083 nudix motif; other site 306537004084 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 306537004085 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 306537004086 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 306537004087 threonine dehydratase; Reviewed; Region: PRK09224 306537004088 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 306537004089 tetramer interface [polypeptide binding]; other site 306537004090 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306537004091 catalytic residue [active] 306537004092 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 306537004093 putative Ile/Val binding site [chemical binding]; other site 306537004094 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 306537004095 putative Ile/Val binding site [chemical binding]; other site 306537004096 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 306537004097 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 306537004098 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 306537004099 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 306537004100 active site 306537004101 catalytic site [active] 306537004102 substrate binding site [chemical binding]; other site 306537004103 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 306537004104 metal ion-dependent adhesion site (MIDAS); other site 306537004105 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 306537004106 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 306537004107 nucleotide binding pocket [chemical binding]; other site 306537004108 K-X-D-G motif; other site 306537004109 catalytic site [active] 306537004110 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 306537004111 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 306537004112 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 306537004113 Dimer interface [polypeptide binding]; other site 306537004114 BRCT sequence motif; other site 306537004115 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 306537004116 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 306537004117 active site 306537004118 catalytic tetrad [active] 306537004119 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 306537004120 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 306537004121 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 306537004122 Ligand Binding Site [chemical binding]; other site 306537004123 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 306537004124 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 306537004125 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 306537004126 catalytic residue [active] 306537004127 AAA ATPase domain; Region: AAA_16; pfam13191 306537004128 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 306537004129 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 306537004130 Ligand Binding Site [chemical binding]; other site 306537004131 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 306537004132 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 306537004133 Ligand binding site [chemical binding]; other site 306537004134 Electron transfer flavoprotein domain; Region: ETF; pfam01012 306537004135 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 306537004136 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306537004137 Walker A/P-loop; other site 306537004138 ATP binding site [chemical binding]; other site 306537004139 Q-loop/lid; other site 306537004140 ABC transporter signature motif; other site 306537004141 Walker B; other site 306537004142 D-loop; other site 306537004143 H-loop/switch region; other site 306537004144 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 306537004145 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 306537004146 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 306537004147 active site 306537004148 homodimer interface [polypeptide binding]; other site 306537004149 catalytic site [active] 306537004150 acceptor binding site [chemical binding]; other site 306537004151 glycogen branching enzyme; Provisional; Region: PRK05402 306537004152 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 306537004153 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 306537004154 active site 306537004155 catalytic site [active] 306537004156 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 306537004157 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 306537004158 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 306537004159 hypothetical protein; Provisional; Region: PRK03298 306537004160 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 306537004161 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 306537004162 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 306537004163 gamma subunit interface [polypeptide binding]; other site 306537004164 epsilon subunit interface [polypeptide binding]; other site 306537004165 LBP interface [polypeptide binding]; other site 306537004166 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 306537004167 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 306537004168 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 306537004169 alpha subunit interaction interface [polypeptide binding]; other site 306537004170 Walker A motif; other site 306537004171 ATP binding site [chemical binding]; other site 306537004172 Walker B motif; other site 306537004173 inhibitor binding site; inhibition site 306537004174 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 306537004175 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 306537004176 core domain interface [polypeptide binding]; other site 306537004177 delta subunit interface [polypeptide binding]; other site 306537004178 epsilon subunit interface [polypeptide binding]; other site 306537004179 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 306537004180 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 306537004181 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 306537004182 beta subunit interaction interface [polypeptide binding]; other site 306537004183 Walker A motif; other site 306537004184 ATP binding site [chemical binding]; other site 306537004185 Walker B motif; other site 306537004186 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 306537004187 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 306537004188 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 306537004189 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 306537004190 F0F1 ATP synthase subunit C; Validated; Region: PRK07874 306537004191 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 306537004192 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 306537004193 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 306537004194 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 306537004195 Mg++ binding site [ion binding]; other site 306537004196 putative catalytic motif [active] 306537004197 substrate binding site [chemical binding]; other site 306537004198 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 306537004199 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 306537004200 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306537004201 S-adenosylmethionine binding site [chemical binding]; other site 306537004202 peptide chain release factor 1; Validated; Region: prfA; PRK00591 306537004203 This domain is found in peptide chain release factors; Region: PCRF; smart00937 306537004204 RF-1 domain; Region: RF-1; pfam00472 306537004205 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 306537004206 transcription termination factor Rho; Provisional; Region: PRK12608 306537004207 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 306537004208 RNA binding site [nucleotide binding]; other site 306537004209 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 306537004210 multimer interface [polypeptide binding]; other site 306537004211 Walker A motif; other site 306537004212 ATP binding site [chemical binding]; other site 306537004213 Walker B motif; other site 306537004214 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620 306537004215 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 306537004216 acyl-activating enzyme (AAE) consensus motif; other site 306537004217 AMP binding site [chemical binding]; other site 306537004218 active site 306537004219 CoA binding site [chemical binding]; other site 306537004220 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 306537004221 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 306537004222 homoserine kinase; Provisional; Region: PRK01212 306537004223 threonine synthase; Reviewed; Region: PRK06721 306537004224 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 306537004225 homodimer interface [polypeptide binding]; other site 306537004226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306537004227 catalytic residue [active] 306537004228 homoserine dehydrogenase; Provisional; Region: PRK06349 306537004229 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 306537004230 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 306537004231 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 306537004232 diaminopimelate decarboxylase; Region: lysA; TIGR01048 306537004233 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 306537004234 active site 306537004235 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 306537004236 substrate binding site [chemical binding]; other site 306537004237 catalytic residues [active] 306537004238 dimer interface [polypeptide binding]; other site 306537004239 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 306537004240 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 306537004241 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 306537004242 active site 306537004243 HIGH motif; other site 306537004244 KMSK motif region; other site 306537004245 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 306537004246 tRNA binding surface [nucleotide binding]; other site 306537004247 anticodon binding site; other site 306537004248 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 306537004249 Helix-turn-helix domain; Region: HTH_38; pfam13936 306537004250 Integrase core domain; Region: rve; pfam00665 306537004251 Winged helix-turn helix; Region: HTH_29; pfam13551 306537004252 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 306537004253 DNA-binding interface [nucleotide binding]; DNA binding site 306537004254 Homeodomain-like domain; Region: HTH_32; pfam13565 306537004255 Integrase core domain; Region: rve; pfam00665 306537004256 Integrase core domain; Region: rve_3; pfam13683 306537004257 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306537004258 AAA domain; Region: AAA_23; pfam13476 306537004259 Walker A/P-loop; other site 306537004260 ATP binding site [chemical binding]; other site 306537004261 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 306537004262 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 306537004263 active site 306537004264 metal binding site [ion binding]; metal-binding site 306537004265 DNA binding site [nucleotide binding] 306537004266 Uncharacterized conserved protein [Function unknown]; Region: COG4279 306537004267 SNF2 Helicase protein; Region: DUF3670; pfam12419 306537004268 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 306537004269 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 306537004270 ATP binding site [chemical binding]; other site 306537004271 putative Mg++ binding site [ion binding]; other site 306537004272 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 306537004273 nucleotide binding region [chemical binding]; other site 306537004274 ATP-binding site [chemical binding]; other site 306537004275 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 306537004276 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 306537004277 Na binding site [ion binding]; other site 306537004278 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 306537004279 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 306537004280 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 306537004281 ATP binding site [chemical binding]; other site 306537004282 Mg++ binding site [ion binding]; other site 306537004283 motif III; other site 306537004284 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 306537004285 nucleotide binding region [chemical binding]; other site 306537004286 ATP-binding site [chemical binding]; other site 306537004287 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 306537004288 putative RNA binding site [nucleotide binding]; other site 306537004289 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 306537004290 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 306537004291 hydroxyglutarate oxidase; Provisional; Region: PRK11728 306537004292 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 306537004293 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 306537004294 substrate binding pocket [chemical binding]; other site 306537004295 catalytic triad [active] 306537004296 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 306537004297 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 306537004298 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306537004299 Walker A/P-loop; other site 306537004300 ATP binding site [chemical binding]; other site 306537004301 Q-loop/lid; other site 306537004302 ABC transporter signature motif; other site 306537004303 Walker B; other site 306537004304 D-loop; other site 306537004305 H-loop/switch region; other site 306537004306 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 306537004307 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 306537004308 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306537004309 Q-loop/lid; other site 306537004310 ABC transporter signature motif; other site 306537004311 Walker B; other site 306537004312 D-loop; other site 306537004313 H-loop/switch region; other site 306537004314 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 306537004315 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 306537004316 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 306537004317 TPP-binding site [chemical binding]; other site 306537004318 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 306537004319 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 306537004320 MgtE intracellular N domain; Region: MgtE_N; smart00924 306537004321 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 306537004322 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 306537004323 Domain of unknown function DUF59; Region: DUF59; pfam01883 306537004324 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 306537004325 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 306537004326 sec-independent translocase; Provisional; Region: tatB; PRK00182 306537004327 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 306537004328 Putative zinc-finger; Region: zf-HC2; pfam13490 306537004329 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 306537004330 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 306537004331 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 306537004332 DNA binding residues [nucleotide binding] 306537004333 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 306537004334 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 306537004335 MULE transposase domain; Region: MULE; pfam10551 306537004336 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 306537004337 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 306537004338 ligand binding site; other site 306537004339 oligomer interface; other site 306537004340 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 306537004341 dimer interface [polypeptide binding]; other site 306537004342 N-terminal domain interface [polypeptide binding]; other site 306537004343 sulfate 1 binding site; other site 306537004344 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 306537004345 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 306537004346 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 306537004347 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 306537004348 active site 306537004349 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 306537004350 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 306537004351 Methyltransferase domain; Region: Methyltransf_11; pfam08241 306537004352 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 306537004353 interface (dimer of trimers) [polypeptide binding]; other site 306537004354 Substrate-binding/catalytic site; other site 306537004355 Zn-binding sites [ion binding]; other site 306537004356 DivIVA domain; Region: DivI1A_domain; TIGR03544 306537004357 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 306537004358 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 306537004359 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 306537004360 metal binding site [ion binding]; metal-binding site 306537004361 putative dimer interface [polypeptide binding]; other site 306537004362 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 306537004363 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 306537004364 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 306537004365 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 306537004366 putative trimer interface [polypeptide binding]; other site 306537004367 putative CoA binding site [chemical binding]; other site 306537004368 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 306537004369 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 306537004370 active site 306537004371 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 306537004372 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 306537004373 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306537004374 homodimer interface [polypeptide binding]; other site 306537004375 catalytic residue [active] 306537004376 Ferredoxin [Energy production and conversion]; Region: COG1146 306537004377 4Fe-4S binding domain; Region: Fer4; pfam00037 306537004378 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 306537004379 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 306537004380 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 306537004381 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 306537004382 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 306537004383 G1 box; other site 306537004384 putative GEF interaction site [polypeptide binding]; other site 306537004385 GTP/Mg2+ binding site [chemical binding]; other site 306537004386 Switch I region; other site 306537004387 G2 box; other site 306537004388 G3 box; other site 306537004389 Switch II region; other site 306537004390 G4 box; other site 306537004391 G5 box; other site 306537004392 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 306537004393 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 306537004394 Protein of unknown function (DUF402); Region: DUF402; cl00979 306537004395 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 306537004396 Transposase; Region: HTH_Tnp_1; cl17663 306537004397 putative transposase OrfB; Reviewed; Region: PHA02517 306537004398 HTH-like domain; Region: HTH_21; pfam13276 306537004399 Integrase core domain; Region: rve; pfam00665 306537004400 Integrase core domain; Region: rve_3; pfam13683 306537004401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306537004402 Major Facilitator Superfamily; Region: MFS_1; pfam07690 306537004403 putative substrate translocation pore; other site 306537004404 Homeodomain-like domain; Region: HTH_23; cl17451 306537004405 Winged helix-turn helix; Region: HTH_29; pfam13551 306537004406 Integrase core domain; Region: rve; pfam00665 306537004407 Integrase core domain; Region: rve_3; pfam13683 306537004408 Excalibur calcium-binding domain; Region: Excalibur; smart00894 306537004409 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 306537004410 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 306537004411 active site 306537004412 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 306537004413 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 306537004414 NADH(P)-binding; Region: NAD_binding_10; pfam13460 306537004415 NAD(P) binding site [chemical binding]; other site 306537004416 putative active site [active] 306537004417 Protein of unknown function (DUF808); Region: DUF808; cl01002 306537004418 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 306537004419 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 306537004420 active site 306537004421 nucleophile elbow; other site 306537004422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306537004423 Major Facilitator Superfamily; Region: MFS_1; pfam07690 306537004424 putative substrate translocation pore; other site 306537004425 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 306537004426 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 306537004427 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 306537004428 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 306537004429 putative active site [active] 306537004430 putative metal binding site [ion binding]; other site 306537004431 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 306537004432 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 306537004433 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 306537004434 DNA binding residues [nucleotide binding] 306537004435 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 306537004436 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 306537004437 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 306537004438 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 306537004439 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 306537004440 FtsX-like permease family; Region: FtsX; pfam02687 306537004441 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 306537004442 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 306537004443 Walker A/P-loop; other site 306537004444 ATP binding site [chemical binding]; other site 306537004445 Q-loop/lid; other site 306537004446 ABC transporter signature motif; other site 306537004447 Walker B; other site 306537004448 D-loop; other site 306537004449 H-loop/switch region; other site 306537004450 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 306537004451 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 306537004452 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 306537004453 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 306537004454 non-specific DNA binding site [nucleotide binding]; other site 306537004455 salt bridge; other site 306537004456 sequence-specific DNA binding site [nucleotide binding]; other site 306537004457 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 306537004458 Domain of unknown function (DUF305); Region: DUF305; cl17794 306537004459 Domain of unknown function (DUF305); Region: DUF305; cl17794 306537004460 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 306537004461 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 306537004462 Soluble P-type ATPase [General function prediction only]; Region: COG4087 306537004463 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 306537004464 metal-binding site [ion binding] 306537004465 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 306537004466 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 306537004467 dimerization interface [polypeptide binding]; other site 306537004468 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 306537004469 dimer interface [polypeptide binding]; other site 306537004470 phosphorylation site [posttranslational modification] 306537004471 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 306537004472 ATP binding site [chemical binding]; other site 306537004473 Mg2+ binding site [ion binding]; other site 306537004474 G-X-G motif; other site 306537004475 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 306537004476 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 306537004477 active site 306537004478 phosphorylation site [posttranslational modification] 306537004479 intermolecular recognition site; other site 306537004480 dimerization interface [polypeptide binding]; other site 306537004481 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 306537004482 DNA binding site [nucleotide binding] 306537004483 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 306537004484 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 306537004485 Multicopper oxidase; Region: Cu-oxidase; pfam00394 306537004486 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 306537004487 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 306537004488 Ribosomal RNA adenine dimethylases; Region: rADc; smart00650 306537004489 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 306537004490 dimerization interface [polypeptide binding]; other site 306537004491 putative DNA binding site [nucleotide binding]; other site 306537004492 putative Zn2+ binding site [ion binding]; other site 306537004493 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 306537004494 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 306537004495 Soluble P-type ATPase [General function prediction only]; Region: COG4087 306537004496 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 306537004497 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 306537004498 DNA binding residues [nucleotide binding] 306537004499 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 306537004500 dimer interface [polypeptide binding]; other site 306537004501 metal binding site [ion binding]; metal-binding site 306537004502 mercuric reductase; Region: MerA; TIGR02053 306537004503 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 306537004504 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 306537004505 hypothetical protein; Provisional; Region: PRK09256 306537004506 GTP-binding protein YchF; Reviewed; Region: PRK09601 306537004507 YchF GTPase; Region: YchF; cd01900 306537004508 G1 box; other site 306537004509 GTP/Mg2+ binding site [chemical binding]; other site 306537004510 Switch I region; other site 306537004511 G2 box; other site 306537004512 Switch II region; other site 306537004513 G3 box; other site 306537004514 G4 box; other site 306537004515 G5 box; other site 306537004516 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 306537004517 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 306537004518 Na2 binding site [ion binding]; other site 306537004519 putative substrate binding site 1 [chemical binding]; other site 306537004520 Na binding site 1 [ion binding]; other site 306537004521 putative substrate binding site 2 [chemical binding]; other site 306537004522 Domain of unknown function DUF20; Region: UPF0118; pfam01594 306537004523 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 306537004524 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 306537004525 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 306537004526 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 306537004527 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 306537004528 generic binding surface II; other site 306537004529 generic binding surface I; other site 306537004530 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 306537004531 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 306537004532 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 306537004533 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 306537004534 putative active site [active] 306537004535 fumarate hydratase; Reviewed; Region: fumC; PRK00485 306537004536 Class II fumarases; Region: Fumarase_classII; cd01362 306537004537 active site 306537004538 tetramer interface [polypeptide binding]; other site 306537004539 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 306537004540 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 306537004541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306537004542 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 306537004543 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 306537004544 Coenzyme A binding pocket [chemical binding]; other site 306537004545 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 306537004546 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 306537004547 putative active site [active] 306537004548 PhoH-like protein; Region: PhoH; pfam02562 306537004549 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 306537004550 Transcriptional regulator [Transcription]; Region: LysR; COG0583 306537004551 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 306537004552 dimerization interface [polypeptide binding]; other site 306537004553 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 306537004554 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 306537004555 active site 306537004556 enoyl-CoA hydratase; Provisional; Region: PRK06688 306537004557 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 306537004558 substrate binding site [chemical binding]; other site 306537004559 oxyanion hole (OAH) forming residues; other site 306537004560 trimer interface [polypeptide binding]; other site 306537004561 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 306537004562 Isochorismatase family; Region: Isochorismatase; pfam00857 306537004563 catalytic triad [active] 306537004564 conserved cis-peptide bond; other site 306537004565 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 306537004566 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 306537004567 dimer interface [polypeptide binding]; other site 306537004568 active site 306537004569 glycine-pyridoxal phosphate binding site [chemical binding]; other site 306537004570 folate binding site [chemical binding]; other site 306537004571 pantothenate kinase; Provisional; Region: PRK05439 306537004572 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 306537004573 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 306537004574 Zn binding site [ion binding]; other site 306537004575 ATP-binding site [chemical binding]; other site 306537004576 CoA-binding site [chemical binding]; other site 306537004577 Mg2+-binding site [ion binding]; other site 306537004578 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 306537004579 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 306537004580 catalytic residue [active] 306537004581 putative FPP diphosphate binding site; other site 306537004582 putative FPP binding hydrophobic cleft; other site 306537004583 dimer interface [polypeptide binding]; other site 306537004584 putative IPP diphosphate binding site; other site 306537004585 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 306537004586 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 306537004587 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 306537004588 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 306537004589 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 306537004590 Bax inhibitor 1 like; Region: BaxI_1; cl17691 306537004591 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 306537004592 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 306537004593 NAD(P) binding site [chemical binding]; other site 306537004594 catalytic residues [active] 306537004595 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 306537004596 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 306537004597 short chain dehydrogenase; Provisional; Region: PRK08219 306537004598 classical (c) SDRs; Region: SDR_c; cd05233 306537004599 NAD(P) binding site [chemical binding]; other site 306537004600 active site 306537004601 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 306537004602 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 306537004603 putative substrate binding site [chemical binding]; other site 306537004604 putative ATP binding site [chemical binding]; other site 306537004605 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 306537004606 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 306537004607 catalytic triad [active] 306537004608 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 306537004609 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 306537004610 active site 306537004611 exopolyphosphatase; Region: exo_poly_only; TIGR03706 306537004612 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 306537004613 nucleotide binding site [chemical binding]; other site 306537004614 Uncharacterized conserved protein [Function unknown]; Region: COG1507 306537004615 Septum formation initiator; Region: DivIC; pfam04977 306537004616 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 306537004617 enolase; Provisional; Region: eno; PRK00077 306537004618 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 306537004619 dimer interface [polypeptide binding]; other site 306537004620 metal binding site [ion binding]; metal-binding site 306537004621 substrate binding pocket [chemical binding]; other site 306537004622 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 306537004623 N-acetyl-D-glucosamine binding site [chemical binding]; other site 306537004624 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 306537004625 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 306537004626 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 306537004627 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 306537004628 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 306537004629 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 306537004630 metal binding site [ion binding]; metal-binding site 306537004631 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 306537004632 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 306537004633 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 306537004634 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 306537004635 ABC-ATPase subunit interface; other site 306537004636 dimer interface [polypeptide binding]; other site 306537004637 putative PBP binding regions; other site 306537004638 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 306537004639 homodimer interface [polypeptide binding]; other site 306537004640 metal binding site [ion binding]; metal-binding site 306537004641 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 306537004642 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 306537004643 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 306537004644 ATP binding site [chemical binding]; other site 306537004645 putative Mg++ binding site [ion binding]; other site 306537004646 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 306537004647 nucleotide binding region [chemical binding]; other site 306537004648 ATP-binding site [chemical binding]; other site 306537004649 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 306537004650 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 306537004651 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 306537004652 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 306537004653 Substrate binding site; other site 306537004654 Mg++ binding site; other site 306537004655 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 306537004656 active site 306537004657 substrate binding site [chemical binding]; other site 306537004658 CoA binding site [chemical binding]; other site 306537004659 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 306537004660 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 306537004661 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 306537004662 active site 306537004663 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 306537004664 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 306537004665 5S rRNA interface [nucleotide binding]; other site 306537004666 CTC domain interface [polypeptide binding]; other site 306537004667 L16 interface [polypeptide binding]; other site 306537004668 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 306537004669 putative active site [active] 306537004670 catalytic residue [active] 306537004671 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 306537004672 putative active site [active] 306537004673 catalytic residue [active] 306537004674 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 306537004675 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 306537004676 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 306537004677 catalytic triad [active] 306537004678 catalytic triad [active] 306537004679 oxyanion hole [active] 306537004680 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 306537004681 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 306537004682 G1 box; other site 306537004683 putative GEF interaction site [polypeptide binding]; other site 306537004684 GTP/Mg2+ binding site [chemical binding]; other site 306537004685 Switch I region; other site 306537004686 G2 box; other site 306537004687 G3 box; other site 306537004688 Switch II region; other site 306537004689 G4 box; other site 306537004690 G5 box; other site 306537004691 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 306537004692 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 306537004693 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 306537004694 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 306537004695 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 306537004696 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 306537004697 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 306537004698 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 306537004699 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 306537004700 substrate binding site [chemical binding]; other site 306537004701 oxyanion hole (OAH) forming residues; other site 306537004702 trimer interface [polypeptide binding]; other site 306537004703 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 306537004704 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 306537004705 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 306537004706 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 306537004707 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 306537004708 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 306537004709 Uncharacterized conserved protein [Function unknown]; Region: COG1359 306537004710 Predicted membrane protein [Function unknown]; Region: COG4425 306537004711 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 306537004712 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 306537004713 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 306537004714 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 306537004715 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 306537004716 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 306537004717 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 306537004718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306537004719 S-adenosylmethionine binding site [chemical binding]; other site 306537004720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 306537004721 Domain of unknown function (DUF348); Region: DUF348; pfam03990 306537004722 Domain of unknown function (DUF348); Region: DUF348; pfam03990 306537004723 Domain of unknown function (DUF348); Region: DUF348; pfam03990 306537004724 G5 domain; Region: G5; pfam07501 306537004725 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 306537004726 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 306537004727 active site 306537004728 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 306537004729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306537004730 putative substrate translocation pore; other site 306537004731 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 306537004732 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 306537004733 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 306537004734 active site 306537004735 HIGH motif; other site 306537004736 KMSKS motif; other site 306537004737 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 306537004738 tRNA binding surface [nucleotide binding]; other site 306537004739 anticodon binding site; other site 306537004740 BCCT family transporter; Region: BCCT; pfam02028 306537004741 Predicted methyltransferases [General function prediction only]; Region: COG0313 306537004742 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 306537004743 putative SAM binding site [chemical binding]; other site 306537004744 putative homodimer interface [polypeptide binding]; other site 306537004745 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 306537004746 Predicted integral membrane protein [Function unknown]; Region: COG5660 306537004747 Putative zinc-finger; Region: zf-HC2; pfam13490 306537004748 Predicted membrane protein [Function unknown]; Region: COG2259 306537004749 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 306537004750 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 306537004751 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 306537004752 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 306537004753 dimer interface [polypeptide binding]; other site 306537004754 putative functional site; other site 306537004755 putative MPT binding site; other site 306537004756 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 306537004757 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 306537004758 active site 306537004759 tetramer interface; other site 306537004760 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 306537004761 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 306537004762 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 306537004763 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 306537004764 MPT binding site; other site 306537004765 trimer interface [polypeptide binding]; other site 306537004766 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 306537004767 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 306537004768 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 306537004769 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 306537004770 dimerization interface [polypeptide binding]; other site 306537004771 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 306537004772 dimer interface [polypeptide binding]; other site 306537004773 phosphorylation site [posttranslational modification] 306537004774 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 306537004775 ATP binding site [chemical binding]; other site 306537004776 Mg2+ binding site [ion binding]; other site 306537004777 G-X-G motif; other site 306537004778 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 306537004779 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 306537004780 active site 306537004781 phosphorylation site [posttranslational modification] 306537004782 intermolecular recognition site; other site 306537004783 dimerization interface [polypeptide binding]; other site 306537004784 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 306537004785 DNA binding site [nucleotide binding] 306537004786 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 306537004787 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 306537004788 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 306537004789 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 306537004790 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 306537004791 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 306537004792 RDD family; Region: RDD; pfam06271 306537004793 Predicted permeases [General function prediction only]; Region: COG0679 306537004794 Interferon-induced transmembrane protein; Region: CD225; pfam04505 306537004795 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 306537004796 putative acyltransferase; Provisional; Region: PRK05790 306537004797 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 306537004798 dimer interface [polypeptide binding]; other site 306537004799 active site 306537004800 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 306537004801 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 306537004802 AMP-binding domain protein; Validated; Region: PRK08315 306537004803 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 306537004804 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 306537004805 acyl-activating enzyme (AAE) consensus motif; other site 306537004806 putative AMP binding site [chemical binding]; other site 306537004807 putative active site [active] 306537004808 putative CoA binding site [chemical binding]; other site 306537004809 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 306537004810 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 306537004811 putative active site [active] 306537004812 putative catalytic site [active] 306537004813 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 306537004814 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 306537004815 active site 306537004816 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 306537004817 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 306537004818 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 306537004819 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 306537004820 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 306537004821 carboxyltransferase (CT) interaction site; other site 306537004822 biotinylation site [posttranslational modification]; other site 306537004823 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 306537004824 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 306537004825 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 306537004826 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 306537004827 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 306537004828 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 306537004829 purine monophosphate binding site [chemical binding]; other site 306537004830 dimer interface [polypeptide binding]; other site 306537004831 putative catalytic residues [active] 306537004832 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 306537004833 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 306537004834 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 306537004835 active site 306537004836 substrate binding site [chemical binding]; other site 306537004837 cosubstrate binding site; other site 306537004838 catalytic site [active] 306537004839 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 306537004840 Peptidase family M23; Region: Peptidase_M23; pfam01551 306537004841 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 306537004842 Helix-turn-helix domain; Region: HTH_28; pfam13518 306537004843 HTH-like domain; Region: HTH_21; pfam13276 306537004844 Integrase core domain; Region: rve; pfam00665 306537004845 Integrase core domain; Region: rve_2; pfam13333 306537004846 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 306537004847 active site 306537004848 catalytic triad [active] 306537004849 oxyanion hole [active] 306537004850 acyl-CoA synthetase; Validated; Region: PRK07788 306537004851 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 306537004852 acyl-activating enzyme (AAE) consensus motif; other site 306537004853 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 306537004854 AMP binding site [chemical binding]; other site 306537004855 active site 306537004856 acyl-activating enzyme (AAE) consensus motif; other site 306537004857 CoA binding site [chemical binding]; other site 306537004858 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 306537004859 Part of AAA domain; Region: AAA_19; pfam13245 306537004860 Family description; Region: UvrD_C_2; pfam13538 306537004861 hypothetical protein; Provisional; Region: PRK07857 306537004862 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 306537004863 active site 306537004864 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 306537004865 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 306537004866 dimer interface [polypeptide binding]; other site 306537004867 FMN binding site [chemical binding]; other site 306537004868 NADPH bind site [chemical binding]; other site 306537004869 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 306537004870 Peptidase family M48; Region: Peptidase_M48; cl12018 306537004871 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 306537004872 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 306537004873 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 306537004874 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 306537004875 active site 306537004876 catalytic residues [active] 306537004877 DNA binding site [nucleotide binding] 306537004878 Int/Topo IB signature motif; other site 306537004879 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 306537004880 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 306537004881 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 306537004882 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 306537004883 Sulfate transporter family; Region: Sulfate_transp; pfam00916 306537004884 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 306537004885 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 306537004886 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 306537004887 DNA binding residues [nucleotide binding] 306537004888 Transposase, Mutator family; Region: Transposase_mut; pfam00872 306537004889 MULE transposase domain; Region: MULE; pfam10551 306537004890 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 306537004891 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 306537004892 Helix-turn-helix domain; Region: HTH_38; pfam13936 306537004893 putative transposase OrfB; Reviewed; Region: PHA02517 306537004894 HTH-like domain; Region: HTH_21; pfam13276 306537004895 Integrase core domain; Region: rve; pfam00665 306537004896 Integrase core domain; Region: rve_3; pfam13683 306537004897 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 306537004898 Integrase core domain; Region: rve; pfam00665 306537004899 Transposase, Mutator family; Region: Transposase_mut; pfam00872 306537004900 MULE transposase domain; Region: MULE; pfam10551 306537004901 Transposase; Region: DEDD_Tnp_IS110; pfam01548 306537004902 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 306537004903 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 306537004904 Transposase; Region: HTH_Tnp_1; cl17663 306537004905 putative transposase OrfB; Reviewed; Region: PHA02517 306537004906 HTH-like domain; Region: HTH_21; pfam13276 306537004907 Integrase core domain; Region: rve; pfam00665 306537004908 Integrase core domain; Region: rve_3; pfam13683 306537004909 BCCT family transporter; Region: BCCT; cl00569 306537004910 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 306537004911 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 306537004912 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 306537004913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 306537004914 dimer interface [polypeptide binding]; other site 306537004915 conserved gate region; other site 306537004916 putative PBP binding loops; other site 306537004917 ABC-ATPase subunit interface; other site 306537004918 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 306537004919 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306537004920 Walker A/P-loop; other site 306537004921 ATP binding site [chemical binding]; other site 306537004922 Q-loop/lid; other site 306537004923 ABC transporter signature motif; other site 306537004924 Walker B; other site 306537004925 D-loop; other site 306537004926 H-loop/switch region; other site 306537004927 TOBE domain; Region: TOBE; cl01440 306537004928 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 306537004929 trimer interface [polypeptide binding]; other site 306537004930 dimer interface [polypeptide binding]; other site 306537004931 putative active site [active] 306537004932 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 306537004933 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 306537004934 dimer interface [polypeptide binding]; other site 306537004935 putative functional site; other site 306537004936 putative MPT binding site; other site 306537004937 hypothetical protein; Provisional; Region: PRK08328 306537004938 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 306537004939 ATP binding site [chemical binding]; other site 306537004940 substrate interface [chemical binding]; other site 306537004941 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 306537004942 MoaE homodimer interface [polypeptide binding]; other site 306537004943 MoaD interaction [polypeptide binding]; other site 306537004944 active site residues [active] 306537004945 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 306537004946 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 306537004947 FeS/SAM binding site; other site 306537004948 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 306537004949 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 306537004950 Transposase, Mutator family; Region: Transposase_mut; pfam00872 306537004951 MULE transposase domain; Region: MULE; pfam10551 306537004952 MULE transposase domain; Region: MULE; pfam10551 306537004953 hypothetical protein; Validated; Region: PRK00068 306537004954 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 306537004955 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 306537004956 PDZ domain; Region: PDZ_2; pfam13180 306537004957 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 306537004958 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 306537004959 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 306537004960 Protein of unknown function DUF45; Region: DUF45; cl00636 306537004961 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 306537004962 Part of AAA domain; Region: AAA_19; pfam13245 306537004963 Family description; Region: UvrD_C_2; pfam13538 306537004964 HRDC domain; Region: HRDC; pfam00570 306537004965 Ion channel; Region: Ion_trans_2; pfam07885 306537004966 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 306537004967 TrkA-N domain; Region: TrkA_N; pfam02254 306537004968 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 306537004969 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 306537004970 Part of AAA domain; Region: AAA_19; pfam13245 306537004971 Family description; Region: UvrD_C_2; pfam13538 306537004972 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 306537004973 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 306537004974 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 306537004975 TIGR02569 family protein; Region: TIGR02569_actnb 306537004976 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 306537004977 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 306537004978 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 306537004979 DEAD-like helicases superfamily; Region: DEXDc; smart00487 306537004980 ATP binding site [chemical binding]; other site 306537004981 Mg++ binding site [ion binding]; other site 306537004982 motif III; other site 306537004983 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 306537004984 nucleotide binding region [chemical binding]; other site 306537004985 ATP-binding site [chemical binding]; other site 306537004986 Transcription factor WhiB; Region: Whib; pfam02467 306537004987 MULE transposase domain; Region: MULE; pfam10551 306537004988 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 306537004989 pentamer interface [polypeptide binding]; other site 306537004990 dodecaamer interface [polypeptide binding]; other site 306537004991 anti-sigma factor, TIGR02949 family; Region: anti_SigH_actin 306537004992 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 306537004993 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 306537004994 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 306537004995 DNA binding residues [nucleotide binding] 306537004996 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 306537004997 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 306537004998 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 306537004999 hinge; other site 306537005000 active site 306537005001 Predicted GTPases [General function prediction only]; Region: COG1162 306537005002 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 306537005003 GTPase/Zn-binding domain interface [polypeptide binding]; other site 306537005004 GTP/Mg2+ binding site [chemical binding]; other site 306537005005 G4 box; other site 306537005006 G5 box; other site 306537005007 G1 box; other site 306537005008 Switch I region; other site 306537005009 G2 box; other site 306537005010 G3 box; other site 306537005011 Switch II region; other site 306537005012 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 306537005013 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 306537005014 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 306537005015 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 306537005016 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 306537005017 nucleotide binding region [chemical binding]; other site 306537005018 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 306537005019 30S subunit binding site; other site 306537005020 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 306537005021 lipoprotein LpqB; Provisional; Region: PRK13616 306537005022 Sporulation and spore germination; Region: Germane; pfam10646 306537005023 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 306537005024 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 306537005025 dimerization interface [polypeptide binding]; other site 306537005026 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 306537005027 dimer interface [polypeptide binding]; other site 306537005028 phosphorylation site [posttranslational modification] 306537005029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 306537005030 ATP binding site [chemical binding]; other site 306537005031 Mg2+ binding site [ion binding]; other site 306537005032 G-X-G motif; other site 306537005033 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 306537005034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 306537005035 active site 306537005036 phosphorylation site [posttranslational modification] 306537005037 intermolecular recognition site; other site 306537005038 dimerization interface [polypeptide binding]; other site 306537005039 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 306537005040 DNA binding site [nucleotide binding] 306537005041 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 306537005042 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 306537005043 TMP-binding site; other site 306537005044 ATP-binding site [chemical binding]; other site 306537005045 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 306537005046 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 306537005047 homotetramer interface [polypeptide binding]; other site 306537005048 ligand binding site [chemical binding]; other site 306537005049 catalytic site [active] 306537005050 NAD binding site [chemical binding]; other site 306537005051 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 306537005052 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 306537005053 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 306537005054 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 306537005055 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 306537005056 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 306537005057 active site 306537005058 substrate binding site [chemical binding]; other site 306537005059 metal binding site [ion binding]; metal-binding site 306537005060 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 306537005061 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 306537005062 Transcription factor WhiB; Region: Whib; pfam02467 306537005063 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 306537005064 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 306537005065 active site 306537005066 Substrate binding site; other site 306537005067 Mg++ binding site; other site 306537005068 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 306537005069 putative trimer interface [polypeptide binding]; other site 306537005070 putative CoA binding site [chemical binding]; other site 306537005071 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 306537005072 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 306537005073 Probable Catalytic site; other site 306537005074 metal-binding site 306537005075 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 306537005076 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 306537005077 NADP binding site [chemical binding]; other site 306537005078 active site 306537005079 putative substrate binding site [chemical binding]; other site 306537005080 Transcriptional regulator [Transcription]; Region: LytR; COG1316 306537005081 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 306537005082 TIGR03089 family protein; Region: TIGR03089 306537005083 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 306537005084 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 306537005085 Walker A/P-loop; other site 306537005086 ATP binding site [chemical binding]; other site 306537005087 Q-loop/lid; other site 306537005088 ABC transporter signature motif; other site 306537005089 Walker B; other site 306537005090 D-loop; other site 306537005091 H-loop/switch region; other site 306537005092 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 306537005093 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 306537005094 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 306537005095 Walker A/P-loop; other site 306537005096 ATP binding site [chemical binding]; other site 306537005097 Q-loop/lid; other site 306537005098 ABC transporter signature motif; other site 306537005099 Walker B; other site 306537005100 D-loop; other site 306537005101 H-loop/switch region; other site 306537005102 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 306537005103 active site 306537005104 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 306537005105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 306537005106 active site 306537005107 phosphorylation site [posttranslational modification] 306537005108 intermolecular recognition site; other site 306537005109 dimerization interface [polypeptide binding]; other site 306537005110 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 306537005111 DNA binding residues [nucleotide binding] 306537005112 dimerization interface [polypeptide binding]; other site 306537005113 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 306537005114 Histidine kinase; Region: HisKA_3; pfam07730 306537005115 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 306537005116 ATP binding site [chemical binding]; other site 306537005117 Mg2+ binding site [ion binding]; other site 306537005118 G-X-G motif; other site 306537005119 short chain dehydrogenase; Provisional; Region: PRK08267 306537005120 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306537005121 NAD(P) binding site [chemical binding]; other site 306537005122 active site 306537005123 AIR carboxylase; Region: AIRC; pfam00731 306537005124 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 306537005125 ATP-grasp domain; Region: ATP-grasp; pfam02222 306537005126 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 306537005127 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 306537005128 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 306537005129 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 306537005130 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 306537005131 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 306537005132 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 306537005133 Maf-like protein; Region: Maf; pfam02545 306537005134 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 306537005135 active site 306537005136 dimer interface [polypeptide binding]; other site 306537005137 citrate synthase; Provisional; Region: PRK14033 306537005138 Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111 306537005139 dimer interface [polypeptide binding]; other site 306537005140 active site 306537005141 citrylCoA binding site [chemical binding]; other site 306537005142 oxalacetate/citrate binding site [chemical binding]; other site 306537005143 coenzyme A binding site [chemical binding]; other site 306537005144 catalytic triad [active] 306537005145 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 306537005146 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 306537005147 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 306537005148 active site residue [active] 306537005149 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 306537005150 active site residue [active] 306537005151 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 306537005152 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 306537005153 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 306537005154 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 306537005155 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 306537005156 carboxyltransferase (CT) interaction site; other site 306537005157 biotinylation site [posttranslational modification]; other site 306537005158 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 306537005159 glycerol kinase; Provisional; Region: glpK; PRK00047 306537005160 N- and C-terminal domain interface [polypeptide binding]; other site 306537005161 active site 306537005162 MgATP binding site [chemical binding]; other site 306537005163 catalytic site [active] 306537005164 metal binding site [ion binding]; metal-binding site 306537005165 putative homotetramer interface [polypeptide binding]; other site 306537005166 glycerol binding site [chemical binding]; other site 306537005167 homodimer interface [polypeptide binding]; other site 306537005168 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 306537005169 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 306537005170 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 306537005171 metal binding site [ion binding]; metal-binding site 306537005172 putative dimer interface [polypeptide binding]; other site 306537005173 purine nucleoside phosphorylase; Provisional; Region: PRK08202 306537005174 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 306537005175 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 306537005176 active site 306537005177 substrate binding site [chemical binding]; other site 306537005178 metal binding site [ion binding]; metal-binding site 306537005179 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 306537005180 active site 306537005181 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 306537005182 NlpC/P60 family; Region: NLPC_P60; pfam00877 306537005183 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 306537005184 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306537005185 Walker A/P-loop; other site 306537005186 ATP binding site [chemical binding]; other site 306537005187 Q-loop/lid; other site 306537005188 ABC transporter signature motif; other site 306537005189 Walker B; other site 306537005190 D-loop; other site 306537005191 H-loop/switch region; other site 306537005192 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 306537005193 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 306537005194 TM-ABC transporter signature motif; other site 306537005195 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 306537005196 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 306537005197 putative ligand binding site [chemical binding]; other site 306537005198 adenosine deaminase; Provisional; Region: PRK09358 306537005199 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 306537005200 active site 306537005201 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 306537005202 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 306537005203 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 306537005204 active site 306537005205 HIGH motif; other site 306537005206 dimer interface [polypeptide binding]; other site 306537005207 KMSKS motif; other site 306537005208 Predicted membrane protein [Function unknown]; Region: COG2860 306537005209 UPF0126 domain; Region: UPF0126; pfam03458 306537005210 UPF0126 domain; Region: UPF0126; pfam03458 306537005211 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 306537005212 putative catalytic site [active] 306537005213 putative metal binding site [ion binding]; other site 306537005214 putative phosphate binding site [ion binding]; other site 306537005215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306537005216 Major Facilitator Superfamily; Region: MFS_1; pfam07690 306537005217 putative substrate translocation pore; other site 306537005218 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 306537005219 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 306537005220 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05613 306537005221 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 306537005222 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 306537005223 catalytic residue [active] 306537005224 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 306537005225 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 306537005226 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 306537005227 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 306537005228 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 306537005229 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 306537005230 homodimer interface [polypeptide binding]; other site 306537005231 NADP binding site [chemical binding]; other site 306537005232 substrate binding site [chemical binding]; other site 306537005233 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 306537005234 active site 306537005235 catalytic site [active] 306537005236 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 306537005237 Cna protein B-type domain; Region: Cna_B; pfam05738 306537005238 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 306537005239 Uncharacterized conserved protein [Function unknown]; Region: COG3268 306537005240 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306537005241 NAD(P) binding site [chemical binding]; other site 306537005242 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 306537005243 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 306537005244 active site 306537005245 substrate binding site [chemical binding]; other site 306537005246 FMN binding site [chemical binding]; other site 306537005247 putative catalytic residues [active] 306537005248 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 306537005249 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 306537005250 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 306537005251 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 306537005252 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 306537005253 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 306537005254 active site 306537005255 PHP Thumb interface [polypeptide binding]; other site 306537005256 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 306537005257 generic binding surface II; other site 306537005258 generic binding surface I; other site 306537005259 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 306537005260 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 306537005261 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 306537005262 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 306537005263 Walker A/P-loop; other site 306537005264 ATP binding site [chemical binding]; other site 306537005265 Q-loop/lid; other site 306537005266 ABC transporter signature motif; other site 306537005267 Walker B; other site 306537005268 D-loop; other site 306537005269 H-loop/switch region; other site 306537005270 NIL domain; Region: NIL; pfam09383 306537005271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 306537005272 dimer interface [polypeptide binding]; other site 306537005273 conserved gate region; other site 306537005274 putative PBP binding loops; other site 306537005275 ABC-ATPase subunit interface; other site 306537005276 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 306537005277 Helix-turn-helix domain; Region: HTH_28; pfam13518 306537005278 putative transposase OrfB; Reviewed; Region: PHA02517 306537005279 HTH-like domain; Region: HTH_21; pfam13276 306537005280 Integrase core domain; Region: rve; pfam00665 306537005281 Integrase core domain; Region: rve_2; pfam13333 306537005282 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 306537005283 putative dimer interface [polypeptide binding]; other site 306537005284 putative [2Fe-2S] cluster binding site [ion binding]; other site 306537005285 DNA Polymerase Y-family; Region: PolY_like; cd03468 306537005286 active site 306537005287 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 306537005288 DNA binding site [nucleotide binding] 306537005289 GMP synthase; Reviewed; Region: guaA; PRK00074 306537005290 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 306537005291 AMP/PPi binding site [chemical binding]; other site 306537005292 candidate oxyanion hole; other site 306537005293 catalytic triad [active] 306537005294 potential glutamine specificity residues [chemical binding]; other site 306537005295 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 306537005296 ATP Binding subdomain [chemical binding]; other site 306537005297 Ligand Binding sites [chemical binding]; other site 306537005298 Dimerization subdomain; other site 306537005299 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 306537005300 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 306537005301 phosphate binding site [ion binding]; other site 306537005302 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 306537005303 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 306537005304 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 306537005305 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 306537005306 active site 306537005307 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 306537005308 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 306537005309 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 306537005310 DNA binding residues [nucleotide binding] 306537005311 Transcription factor WhiB; Region: Whib; pfam02467 306537005312 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 306537005313 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 306537005314 ring oligomerisation interface [polypeptide binding]; other site 306537005315 ATP/Mg binding site [chemical binding]; other site 306537005316 stacking interactions; other site 306537005317 hinge regions; other site 306537005318 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 306537005319 oligomerisation interface [polypeptide binding]; other site 306537005320 mobile loop; other site 306537005321 roof hairpin; other site 306537005322 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 306537005323 Glycoprotease family; Region: Peptidase_M22; pfam00814 306537005324 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 306537005325 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 306537005326 Coenzyme A binding pocket [chemical binding]; other site 306537005327 UGMP family protein; Validated; Region: PRK09604 306537005328 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 306537005329 Catalytic domain of Protein Kinases; Region: PKc; cd00180 306537005330 active site 306537005331 ATP binding site [chemical binding]; other site 306537005332 substrate binding site [chemical binding]; other site 306537005333 activation loop (A-loop); other site 306537005334 alanine racemase; Reviewed; Region: alr; PRK00053 306537005335 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 306537005336 active site 306537005337 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 306537005338 dimer interface [polypeptide binding]; other site 306537005339 substrate binding site [chemical binding]; other site 306537005340 catalytic residues [active] 306537005341 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 306537005342 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 306537005343 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 306537005344 glutaminase active site [active] 306537005345 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 306537005346 dimer interface [polypeptide binding]; other site 306537005347 active site 306537005348 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 306537005349 dimer interface [polypeptide binding]; other site 306537005350 active site 306537005351 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 306537005352 Transcriptional regulator [Transcription]; Region: LysR; COG0583 306537005353 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 306537005354 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 306537005355 putative dimerization interface [polypeptide binding]; other site 306537005356 EamA-like transporter family; Region: EamA; pfam00892 306537005357 EamA-like transporter family; Region: EamA; pfam00892 306537005358 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306537005359 NADH(P)-binding; Region: NAD_binding_10; pfam13460 306537005360 NAD(P) binding site [chemical binding]; other site 306537005361 active site 306537005362 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 306537005363 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 306537005364 active site 306537005365 substrate binding site [chemical binding]; other site 306537005366 metal binding site [ion binding]; metal-binding site 306537005367 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 306537005368 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 306537005369 23S rRNA interface [nucleotide binding]; other site 306537005370 L3 interface [polypeptide binding]; other site 306537005371 PRC-barrel domain; Region: PRC; pfam05239 306537005372 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 306537005373 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 306537005374 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 306537005375 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 306537005376 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 306537005377 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 306537005378 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 306537005379 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 306537005380 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 306537005381 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 306537005382 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 306537005383 active site 306537005384 catalytic residues [active] 306537005385 Protein of unknown function (DUF690); Region: DUF690; cl04939 306537005386 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 306537005387 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 306537005388 dimerization interface 3.5A [polypeptide binding]; other site 306537005389 active site 306537005390 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 306537005391 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 306537005392 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 306537005393 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 306537005394 alphaNTD - beta interaction site [polypeptide binding]; other site 306537005395 alphaNTD homodimer interface [polypeptide binding]; other site 306537005396 alphaNTD - beta' interaction site [polypeptide binding]; other site 306537005397 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 306537005398 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 306537005399 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 306537005400 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 306537005401 RNA binding surface [nucleotide binding]; other site 306537005402 30S ribosomal protein S11; Validated; Region: PRK05309 306537005403 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 306537005404 30S ribosomal protein S13; Region: bact_S13; TIGR03631 306537005405 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 306537005406 rRNA binding site [nucleotide binding]; other site 306537005407 predicted 30S ribosome binding site; other site 306537005408 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 306537005409 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 306537005410 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 306537005411 active site 306537005412 adenylate kinase; Reviewed; Region: adk; PRK00279 306537005413 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 306537005414 AMP-binding site [chemical binding]; other site 306537005415 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 306537005416 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 306537005417 SecY translocase; Region: SecY; pfam00344 306537005418 Integrase core domain; Region: rve; pfam00665 306537005419 Integrase core domain; Region: rve_3; pfam13683 306537005420 putative transposase OrfB; Reviewed; Region: PHA02517 306537005421 HTH-like domain; Region: HTH_21; pfam13276 306537005422 Integrase core domain; Region: rve; pfam00665 306537005423 Integrase core domain; Region: rve_3; pfam13683 306537005424 Transposase; Region: HTH_Tnp_1; cl17663 306537005425 MULE transposase domain; Region: MULE; pfam10551 306537005426 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 306537005427 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 306537005428 ABC-ATPase subunit interface; other site 306537005429 dimer interface [polypeptide binding]; other site 306537005430 putative PBP binding regions; other site 306537005431 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 306537005432 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 306537005433 ABC-ATPase subunit interface; other site 306537005434 dimer interface [polypeptide binding]; other site 306537005435 putative PBP binding regions; other site 306537005436 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 306537005437 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 306537005438 Walker A/P-loop; other site 306537005439 ATP binding site [chemical binding]; other site 306537005440 Q-loop/lid; other site 306537005441 ABC transporter signature motif; other site 306537005442 Walker B; other site 306537005443 D-loop; other site 306537005444 H-loop/switch region; other site 306537005445 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 306537005446 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 306537005447 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 306537005448 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 306537005449 siderophore binding site; other site 306537005450 putative formyltransferase; Provisional; Region: PRK06988 306537005451 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 306537005452 active site 306537005453 substrate binding site [chemical binding]; other site 306537005454 cosubstrate binding site; other site 306537005455 catalytic site [active] 306537005456 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 306537005457 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 306537005458 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 306537005459 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 306537005460 acyl-activating enzyme (AAE) consensus motif; other site 306537005461 AMP binding site [chemical binding]; other site 306537005462 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 306537005463 Condensation domain; Region: Condensation; pfam00668 306537005464 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 306537005465 Condensation domain; Region: Condensation; pfam00668 306537005466 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 306537005467 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 306537005468 acyl-activating enzyme (AAE) consensus motif; other site 306537005469 AMP binding site [chemical binding]; other site 306537005470 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 306537005471 Condensation domain; Region: Condensation; pfam00668 306537005472 Condensation domain; Region: Condensation; pfam00668 306537005473 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 306537005474 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 306537005475 acyl-activating enzyme (AAE) consensus motif; other site 306537005476 AMP binding site [chemical binding]; other site 306537005477 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 306537005478 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 306537005479 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 306537005480 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 306537005481 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306537005482 Q-loop/lid; other site 306537005483 ABC transporter signature motif; other site 306537005484 Walker B; other site 306537005485 D-loop; other site 306537005486 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 306537005487 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 306537005488 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306537005489 Walker A/P-loop; other site 306537005490 ATP binding site [chemical binding]; other site 306537005491 Q-loop/lid; other site 306537005492 ABC transporter signature motif; other site 306537005493 Walker B; other site 306537005494 D-loop; other site 306537005495 H-loop/switch region; other site 306537005496 MbtH-like protein; Region: MbtH; pfam03621 306537005497 Transposase, Mutator family; Region: Transposase_mut; pfam00872 306537005498 MULE transposase domain; Region: MULE; pfam10551 306537005499 Transposase, Mutator family; Region: Transposase_mut; pfam00872 306537005500 MULE transposase domain; Region: MULE; pfam10551 306537005501 Transposase, Mutator family; Region: Transposase_mut; pfam00872 306537005502 Transposase, Mutator family; Region: Transposase_mut; pfam00872 306537005503 MULE transposase domain; Region: MULE; pfam10551 306537005504 Transposase; Region: HTH_Tnp_1; cl17663 306537005505 putative transposase OrfB; Reviewed; Region: PHA02517 306537005506 HTH-like domain; Region: HTH_21; pfam13276 306537005507 Integrase core domain; Region: rve; pfam00665 306537005508 Integrase core domain; Region: rve_3; pfam13683 306537005509 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 306537005510 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 306537005511 23S rRNA binding site [nucleotide binding]; other site 306537005512 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 306537005513 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 306537005514 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 306537005515 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 306537005516 23S rRNA interface [nucleotide binding]; other site 306537005517 L21e interface [polypeptide binding]; other site 306537005518 5S rRNA interface [nucleotide binding]; other site 306537005519 L27 interface [polypeptide binding]; other site 306537005520 L5 interface [polypeptide binding]; other site 306537005521 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 306537005522 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 306537005523 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 306537005524 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 306537005525 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 306537005526 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 306537005527 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 306537005528 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 306537005529 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 306537005530 RNA binding site [nucleotide binding]; other site 306537005531 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 306537005532 putative transposase OrfB; Reviewed; Region: PHA02517 306537005533 HTH-like domain; Region: HTH_21; pfam13276 306537005534 Integrase core domain; Region: rve; pfam00665 306537005535 Integrase core domain; Region: rve_2; pfam13333 306537005536 Helix-turn-helix domain; Region: HTH_28; pfam13518 306537005537 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 306537005538 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 306537005539 FAD binding pocket [chemical binding]; other site 306537005540 FAD binding motif [chemical binding]; other site 306537005541 phosphate binding motif [ion binding]; other site 306537005542 NAD binding pocket [chemical binding]; other site 306537005543 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 306537005544 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 306537005545 Walker A/P-loop; other site 306537005546 ATP binding site [chemical binding]; other site 306537005547 Q-loop/lid; other site 306537005548 ABC transporter signature motif; other site 306537005549 Walker B; other site 306537005550 D-loop; other site 306537005551 H-loop/switch region; other site 306537005552 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 306537005553 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 306537005554 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 306537005555 dimer interface [polypeptide binding]; other site 306537005556 putative PBP binding regions; other site 306537005557 ABC-ATPase subunit interface; other site 306537005558 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 306537005559 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 306537005560 ABC-ATPase subunit interface; other site 306537005561 dimer interface [polypeptide binding]; other site 306537005562 putative PBP binding regions; other site 306537005563 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 306537005564 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 306537005565 siderophore binding site; other site 306537005566 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 306537005567 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 306537005568 FAD binding pocket [chemical binding]; other site 306537005569 FAD binding motif [chemical binding]; other site 306537005570 phosphate binding motif [ion binding]; other site 306537005571 NAD binding pocket [chemical binding]; other site 306537005572 Condensation domain; Region: Condensation; pfam00668 306537005573 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 306537005574 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 306537005575 acyl-activating enzyme (AAE) consensus motif; other site 306537005576 AMP binding site [chemical binding]; other site 306537005577 Condensation domain; Region: Condensation; pfam00668 306537005578 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 306537005579 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 306537005580 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 306537005581 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 306537005582 intersubunit interface [polypeptide binding]; other site 306537005583 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 306537005584 AMP-binding enzyme; Region: AMP-binding; pfam00501 306537005585 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 306537005586 acyl-activating enzyme (AAE) consensus motif; other site 306537005587 AMP binding site [chemical binding]; other site 306537005588 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 306537005589 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 306537005590 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 306537005591 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 306537005592 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 306537005593 ABC-ATPase subunit interface; other site 306537005594 dimer interface [polypeptide binding]; other site 306537005595 putative PBP binding regions; other site 306537005596 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 306537005597 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 306537005598 ABC-ATPase subunit interface; other site 306537005599 dimer interface [polypeptide binding]; other site 306537005600 putative PBP binding regions; other site 306537005601 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 306537005602 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 306537005603 Walker A/P-loop; other site 306537005604 ATP binding site [chemical binding]; other site 306537005605 Q-loop/lid; other site 306537005606 ABC transporter signature motif; other site 306537005607 Walker B; other site 306537005608 D-loop; other site 306537005609 H-loop/switch region; other site 306537005610 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 306537005611 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 306537005612 putative NAD(P) binding site [chemical binding]; other site 306537005613 active site 306537005614 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 306537005615 Isochorismatase family; Region: Isochorismatase; pfam00857 306537005616 catalytic triad [active] 306537005617 conserved cis-peptide bond; other site 306537005618 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 306537005619 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 306537005620 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 306537005621 acyl-activating enzyme (AAE) consensus motif; other site 306537005622 active site 306537005623 AMP binding site [chemical binding]; other site 306537005624 substrate binding site [chemical binding]; other site 306537005625 Phosphopantetheine attachment site; Region: PP-binding; cl09936 306537005626 Winged helix-turn helix; Region: HTH_29; pfam13551 306537005627 Helix-turn-helix domain; Region: HTH_28; pfam13518 306537005628 putative transposase OrfB; Reviewed; Region: PHA02517 306537005629 HTH-like domain; Region: HTH_21; pfam13276 306537005630 Integrase core domain; Region: rve; pfam00665 306537005631 Integrase core domain; Region: rve_2; pfam13333 306537005632 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 306537005633 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 306537005634 putative translocon interaction site; other site 306537005635 signal recognition particle (SRP54) interaction site; other site 306537005636 L23 interface [polypeptide binding]; other site 306537005637 trigger factor interaction site; other site 306537005638 23S rRNA interface [nucleotide binding]; other site 306537005639 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 306537005640 23S rRNA interface [nucleotide binding]; other site 306537005641 5S rRNA interface [nucleotide binding]; other site 306537005642 putative antibiotic binding site [chemical binding]; other site 306537005643 L25 interface [polypeptide binding]; other site 306537005644 L27 interface [polypeptide binding]; other site 306537005645 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 306537005646 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 306537005647 G-X-X-G motif; other site 306537005648 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 306537005649 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 306537005650 protein-rRNA interface [nucleotide binding]; other site 306537005651 putative translocon binding site; other site 306537005652 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 306537005653 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 306537005654 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 306537005655 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 306537005656 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 306537005657 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 306537005658 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 306537005659 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 306537005660 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 306537005661 active site 306537005662 putative catalytic site [active] 306537005663 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 306537005664 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 306537005665 DNA-binding site [nucleotide binding]; DNA binding site 306537005666 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 306537005667 elongation factor Tu; Reviewed; Region: PRK00049 306537005668 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 306537005669 G1 box; other site 306537005670 GEF interaction site [polypeptide binding]; other site 306537005671 GTP/Mg2+ binding site [chemical binding]; other site 306537005672 Switch I region; other site 306537005673 G2 box; other site 306537005674 G3 box; other site 306537005675 Switch II region; other site 306537005676 G4 box; other site 306537005677 G5 box; other site 306537005678 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 306537005679 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 306537005680 Antibiotic Binding Site [chemical binding]; other site 306537005681 elongation factor G; Reviewed; Region: PRK00007 306537005682 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 306537005683 G1 box; other site 306537005684 putative GEF interaction site [polypeptide binding]; other site 306537005685 GTP/Mg2+ binding site [chemical binding]; other site 306537005686 Switch I region; other site 306537005687 G2 box; other site 306537005688 G3 box; other site 306537005689 Switch II region; other site 306537005690 G4 box; other site 306537005691 G5 box; other site 306537005692 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 306537005693 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 306537005694 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 306537005695 30S ribosomal protein S7; Validated; Region: PRK05302 306537005696 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 306537005697 S17 interaction site [polypeptide binding]; other site 306537005698 S8 interaction site; other site 306537005699 16S rRNA interaction site [nucleotide binding]; other site 306537005700 streptomycin interaction site [chemical binding]; other site 306537005701 23S rRNA interaction site [nucleotide binding]; other site 306537005702 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 306537005703 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 306537005704 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 306537005705 nucleotide binding region [chemical binding]; other site 306537005706 ATP-binding site [chemical binding]; other site 306537005707 Helicase associated domain (HA2); Region: HA2; pfam04408 306537005708 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 306537005709 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 306537005710 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 306537005711 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 306537005712 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 306537005713 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 306537005714 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 306537005715 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 306537005716 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 306537005717 DNA binding site [nucleotide binding] 306537005718 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 306537005719 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 306537005720 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 306537005721 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 306537005722 RPB1 interaction site [polypeptide binding]; other site 306537005723 RPB10 interaction site [polypeptide binding]; other site 306537005724 RPB11 interaction site [polypeptide binding]; other site 306537005725 RPB3 interaction site [polypeptide binding]; other site 306537005726 RPB12 interaction site [polypeptide binding]; other site 306537005727 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 306537005728 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 306537005729 L11 interface [polypeptide binding]; other site 306537005730 putative EF-Tu interaction site [polypeptide binding]; other site 306537005731 putative EF-G interaction site [polypeptide binding]; other site 306537005732 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 306537005733 23S rRNA interface [nucleotide binding]; other site 306537005734 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 306537005735 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 306537005736 Lipase (class 2); Region: Lipase_2; pfam01674 306537005737 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 306537005738 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 306537005739 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 306537005740 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 306537005741 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 306537005742 ABC-ATPase subunit interface; other site 306537005743 dimer interface [polypeptide binding]; other site 306537005744 putative PBP binding regions; other site 306537005745 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 306537005746 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 306537005747 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 306537005748 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 306537005749 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 306537005750 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 306537005751 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 306537005752 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 306537005753 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 306537005754 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 306537005755 NgoMIV restriction enzyme; Region: NgoMIV_restric; pfam09015 306537005756 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 306537005757 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 306537005758 cofactor binding site; other site 306537005759 DNA binding site [nucleotide binding] 306537005760 substrate interaction site [chemical binding]; other site 306537005761 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 306537005762 mRNA/rRNA interface [nucleotide binding]; other site 306537005763 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 306537005764 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 306537005765 23S rRNA interface [nucleotide binding]; other site 306537005766 L7/L12 interface [polypeptide binding]; other site 306537005767 putative thiostrepton binding site; other site 306537005768 L25 interface [polypeptide binding]; other site 306537005769 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 306537005770 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 306537005771 putative homodimer interface [polypeptide binding]; other site 306537005772 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 306537005773 heterodimer interface [polypeptide binding]; other site 306537005774 homodimer interface [polypeptide binding]; other site 306537005775 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 306537005776 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 306537005777 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 306537005778 substrate binding pocket [chemical binding]; other site 306537005779 chain length determination region; other site 306537005780 substrate-Mg2+ binding site; other site 306537005781 catalytic residues [active] 306537005782 aspartate-rich region 1; other site 306537005783 active site lid residues [active] 306537005784 aspartate-rich region 2; other site 306537005785 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 306537005786 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 306537005787 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306537005788 S-adenosylmethionine binding site [chemical binding]; other site 306537005789 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 306537005790 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 306537005791 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 306537005792 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 306537005793 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 306537005794 dimer interface [polypeptide binding]; other site 306537005795 tetramer interface [polypeptide binding]; other site 306537005796 PYR/PP interface [polypeptide binding]; other site 306537005797 TPP binding site [chemical binding]; other site 306537005798 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 306537005799 TPP-binding site; other site 306537005800 O-succinylbenzoate synthase; Provisional; Region: PRK02901 306537005801 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 306537005802 active site 306537005803 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 306537005804 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 306537005805 substrate binding site [chemical binding]; other site 306537005806 oxyanion hole (OAH) forming residues; other site 306537005807 trimer interface [polypeptide binding]; other site 306537005808 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 306537005809 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 306537005810 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306537005811 Walker A/P-loop; other site 306537005812 ATP binding site [chemical binding]; other site 306537005813 Q-loop/lid; other site 306537005814 ABC transporter signature motif; other site 306537005815 Walker B; other site 306537005816 D-loop; other site 306537005817 H-loop/switch region; other site 306537005818 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 306537005819 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 306537005820 active site 306537005821 Predicted membrane protein [Function unknown]; Region: COG2259 306537005822 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 306537005823 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 306537005824 acyl-activating enzyme (AAE) consensus motif; other site 306537005825 AMP binding site [chemical binding]; other site 306537005826 active site 306537005827 CoA binding site [chemical binding]; other site 306537005828 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 306537005829 UbiA prenyltransferase family; Region: UbiA; pfam01040 306537005830 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 306537005831 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 306537005832 active site 306537005833 ATP binding site [chemical binding]; other site 306537005834 Phosphotransferase enzyme family; Region: APH; pfam01636 306537005835 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 306537005836 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 306537005837 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 306537005838 substrate binding site; other site 306537005839 tetramer interface; other site 306537005840 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 306537005841 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 306537005842 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 306537005843 Walker A/P-loop; other site 306537005844 ATP binding site [chemical binding]; other site 306537005845 Q-loop/lid; other site 306537005846 ABC transporter signature motif; other site 306537005847 Walker B; other site 306537005848 D-loop; other site 306537005849 H-loop/switch region; other site 306537005850 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 306537005851 dimer interface [polypeptide binding]; other site 306537005852 ABC-ATPase subunit interface; other site 306537005853 putative PBP binding regions; other site 306537005854 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 306537005855 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 306537005856 ABC-ATPase subunit interface; other site 306537005857 dimer interface [polypeptide binding]; other site 306537005858 putative PBP binding regions; other site 306537005859 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 306537005860 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 306537005861 intersubunit interface [polypeptide binding]; other site 306537005862 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 306537005863 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 306537005864 NAD binding site [chemical binding]; other site 306537005865 substrate binding site [chemical binding]; other site 306537005866 homodimer interface [polypeptide binding]; other site 306537005867 active site 306537005868 Cupin domain; Region: Cupin_2; cl17218 306537005869 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 306537005870 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 306537005871 ResB-like family; Region: ResB; pfam05140 306537005872 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 306537005873 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 306537005874 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 306537005875 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 306537005876 catalytic residues [active] 306537005877 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 306537005878 catalytic core [active] 306537005879 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 306537005880 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 306537005881 inhibitor-cofactor binding pocket; inhibition site 306537005882 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306537005883 catalytic residue [active] 306537005884 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 306537005885 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 306537005886 Soluble P-type ATPase [General function prediction only]; Region: COG4087 306537005887 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 306537005888 dimer interface [polypeptide binding]; other site 306537005889 active site 306537005890 Schiff base residues; other site 306537005891 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 306537005892 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 306537005893 active site 306537005894 SAM binding site [chemical binding]; other site 306537005895 homodimer interface [polypeptide binding]; other site 306537005896 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 306537005897 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 306537005898 active site 306537005899 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 306537005900 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 306537005901 domain interfaces; other site 306537005902 active site 306537005903 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 306537005904 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 306537005905 tRNA; other site 306537005906 putative tRNA binding site [nucleotide binding]; other site 306537005907 putative NADP binding site [chemical binding]; other site 306537005908 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 306537005909 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 306537005910 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 306537005911 motif II; other site 306537005912 DNA binding domain, excisionase family; Region: excise; TIGR01764 306537005913 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 306537005914 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 306537005915 exopolyphosphatase; Region: exo_poly_only; TIGR03706 306537005916 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 306537005917 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 306537005918 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 306537005919 active site 306537005920 phosphorylation site [posttranslational modification] 306537005921 intermolecular recognition site; other site 306537005922 dimerization interface [polypeptide binding]; other site 306537005923 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 306537005924 DNA binding site [nucleotide binding] 306537005925 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 306537005926 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 306537005927 dimer interface [polypeptide binding]; other site 306537005928 phosphorylation site [posttranslational modification] 306537005929 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 306537005930 ATP binding site [chemical binding]; other site 306537005931 Mg2+ binding site [ion binding]; other site 306537005932 G-X-G motif; other site 306537005933 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 306537005934 catalytic core [active] 306537005935 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 306537005936 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 306537005937 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 306537005938 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 306537005939 putative ADP-binding pocket [chemical binding]; other site 306537005940 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 306537005941 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 306537005942 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 306537005943 acyl-activating enzyme (AAE) consensus motif; other site 306537005944 AMP binding site [chemical binding]; other site 306537005945 active site 306537005946 CoA binding site [chemical binding]; other site 306537005947 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 306537005948 Fatty acid desaturase; Region: FA_desaturase; pfam00487 306537005949 Di-iron ligands [ion binding]; other site 306537005950 Rubredoxin [Energy production and conversion]; Region: COG1773 306537005951 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 306537005952 iron binding site [ion binding]; other site 306537005953 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 306537005954 FAD binding domain; Region: FAD_binding_4; pfam01565 306537005955 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 306537005956 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 306537005957 Methyltransferase domain; Region: Methyltransf_23; pfam13489 306537005958 Methyltransferase domain; Region: Methyltransf_12; pfam08242 306537005959 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 306537005960 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 306537005961 intersubunit interface [polypeptide binding]; other site 306537005962 active site 306537005963 catalytic residue [active] 306537005964 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 306537005965 Predicted membrane protein [Function unknown]; Region: COG2733 306537005966 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 306537005967 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 306537005968 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 306537005969 L-aspartate oxidase; Provisional; Region: PRK06175 306537005970 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 306537005971 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 306537005972 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 306537005973 putative Iron-sulfur protein interface [polypeptide binding]; other site 306537005974 proximal heme binding site [chemical binding]; other site 306537005975 distal heme binding site [chemical binding]; other site 306537005976 putative dimer interface [polypeptide binding]; other site 306537005977 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 306537005978 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 306537005979 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 306537005980 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 306537005981 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 306537005982 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 306537005983 motif II; other site 306537005984 malate synthase G; Provisional; Region: PRK02999 306537005985 active site 306537005986 isocitrate lyase; Provisional; Region: PRK15063 306537005987 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 306537005988 tetramer interface [polypeptide binding]; other site 306537005989 active site 306537005990 Mg2+/Mn2+ binding site [ion binding]; other site 306537005991 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 306537005992 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 306537005993 non-specific DNA binding site [nucleotide binding]; other site 306537005994 salt bridge; other site 306537005995 sequence-specific DNA binding site [nucleotide binding]; other site 306537005996 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 306537005997 Domain of unknown function (DUF955); Region: DUF955; pfam06114 306537005998 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 306537005999 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 306537006000 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 306537006001 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 306537006002 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 306537006003 Putative esterase; Region: Esterase; pfam00756 306537006004 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 306537006005 Zn binding site [ion binding]; other site 306537006006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306537006007 Major Facilitator Superfamily; Region: MFS_1; pfam07690 306537006008 putative substrate translocation pore; other site 306537006009 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 306537006010 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 306537006011 active site 306537006012 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 306537006013 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 306537006014 Transposase, Mutator family; Region: Transposase_mut; pfam00872 306537006015 MULE transposase domain; Region: MULE; pfam10551 306537006016 The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Region: 2A067; TIGR00921 306537006017 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 306537006018 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 306537006019 putative acyl-acceptor binding pocket; other site 306537006020 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 306537006021 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 306537006022 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 306537006023 hydrophobic ligand binding site; other site 306537006024 Transcriptional regulators [Transcription]; Region: MarR; COG1846 306537006025 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 306537006026 DNA polymerase III subunit delta'; Validated; Region: PRK07940 306537006027 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 306537006028 dimerization interface [polypeptide binding]; other site 306537006029 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 306537006030 cyclase homology domain; Region: CHD; cd07302 306537006031 nucleotidyl binding site; other site 306537006032 metal binding site [ion binding]; metal-binding site 306537006033 dimer interface [polypeptide binding]; other site 306537006034 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 306537006035 CoA-transferase family III; Region: CoA_transf_3; pfam02515 306537006036 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 306537006037 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 306537006038 active site 306537006039 interdomain interaction site; other site 306537006040 putative metal-binding site [ion binding]; other site 306537006041 nucleotide binding site [chemical binding]; other site 306537006042 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 306537006043 domain I; other site 306537006044 phosphate binding site [ion binding]; other site 306537006045 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 306537006046 domain II; other site 306537006047 domain III; other site 306537006048 nucleotide binding site [chemical binding]; other site 306537006049 DNA binding groove [nucleotide binding] 306537006050 catalytic site [active] 306537006051 domain IV; other site 306537006052 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 306537006053 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 306537006054 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 306537006055 DNA-binding site [nucleotide binding]; DNA binding site 306537006056 RNA-binding motif; other site 306537006057 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 306537006058 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 306537006059 ATP binding site [chemical binding]; other site 306537006060 putative Mg++ binding site [ion binding]; other site 306537006061 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 306537006062 nucleotide binding region [chemical binding]; other site 306537006063 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 306537006064 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 306537006065 Secretory lipase; Region: LIP; pfam03583 306537006066 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 306537006067 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 306537006068 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 306537006069 Type II/IV secretion system protein; Region: T2SE; pfam00437 306537006070 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 306537006071 ATP binding site [chemical binding]; other site 306537006072 Walker A motif; other site 306537006073 hexamer interface [polypeptide binding]; other site 306537006074 Walker B motif; other site 306537006075 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 306537006076 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 306537006077 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 306537006078 motif II; other site 306537006079 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 306537006080 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 306537006081 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 306537006082 Colicin V production protein; Region: Colicin_V; pfam02674 306537006083 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 306537006084 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 306537006085 putative active site [active] 306537006086 putative CoA binding site [chemical binding]; other site 306537006087 nudix motif; other site 306537006088 metal binding site [ion binding]; metal-binding site 306537006089 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 306537006090 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 306537006091 catalytic residues [active] 306537006092 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 306537006093 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 306537006094 minor groove reading motif; other site 306537006095 helix-hairpin-helix signature motif; other site 306537006096 substrate binding pocket [chemical binding]; other site 306537006097 active site 306537006098 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 306537006099 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 306537006100 ligand binding site [chemical binding]; other site 306537006101 flexible hinge region; other site 306537006102 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 306537006103 putative switch regulator; other site 306537006104 non-specific DNA interactions [nucleotide binding]; other site 306537006105 DNA binding site [nucleotide binding] 306537006106 sequence specific DNA binding site [nucleotide binding]; other site 306537006107 putative cAMP binding site [chemical binding]; other site 306537006108 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 306537006109 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 306537006110 homotrimer interaction site [polypeptide binding]; other site 306537006111 putative active site [active] 306537006112 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 306537006113 Transcription factor WhiB; Region: Whib; pfam02467 306537006114 Transglycosylase; Region: Transgly; pfam00912 306537006115 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 306537006116 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 306537006117 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 306537006118 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 306537006119 putative active site [active] 306537006120 putative metal binding site [ion binding]; other site 306537006121 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 306537006122 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 306537006123 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842 306537006124 dimer interface [polypeptide binding]; other site 306537006125 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 306537006126 active site 306537006127 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 306537006128 catalytic residues [active] 306537006129 substrate binding site [chemical binding]; other site 306537006130 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 306537006131 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 306537006132 dimer interface [polypeptide binding]; other site 306537006133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306537006134 catalytic residue [active] 306537006135 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 306537006136 multidrug efflux protein NorA; Provisional; Region: PRK00187 306537006137 cation binding site [ion binding]; other site 306537006138 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 306537006139 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 306537006140 putative ligand binding residues [chemical binding]; other site 306537006141 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 306537006142 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 306537006143 ABC-ATPase subunit interface; other site 306537006144 dimer interface [polypeptide binding]; other site 306537006145 putative PBP binding regions; other site 306537006146 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 306537006147 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 306537006148 Walker A/P-loop; other site 306537006149 ATP binding site [chemical binding]; other site 306537006150 Q-loop/lid; other site 306537006151 ABC transporter signature motif; other site 306537006152 Walker B; other site 306537006153 D-loop; other site 306537006154 H-loop/switch region; other site 306537006155 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 306537006156 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 306537006157 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 306537006158 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 306537006159 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 306537006160 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 306537006161 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 306537006162 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654 306537006163 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612 306537006164 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 306537006165 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 306537006166 MULE transposase domain; Region: MULE; pfam10551 306537006167 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 306537006168 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 306537006169 Catalases are antioxidant enzymes that catalyse the conversion of hydrogen peroxide to water and molecular oxygen, serving to protect cells from its toxic effects; Region: Catalase; smart01060 306537006170 heme binding pocket [chemical binding]; other site 306537006171 Catalase-related immune-responsive; Region: Catalase-rel; pfam06628 306537006172 RNA polymerase sigma factor; Provisional; Region: PRK12535 306537006173 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 306537006174 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 306537006175 DNA binding residues [nucleotide binding] 306537006176 ferrochelatase; Reviewed; Region: hemH; PRK00035 306537006177 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 306537006178 C-terminal domain interface [polypeptide binding]; other site 306537006179 active site 306537006180 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 306537006181 active site 306537006182 N-terminal domain interface [polypeptide binding]; other site 306537006183 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 306537006184 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 306537006185 aspartate kinase; Reviewed; Region: PRK06635 306537006186 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 306537006187 putative nucleotide binding site [chemical binding]; other site 306537006188 putative catalytic residues [active] 306537006189 putative Mg ion binding site [ion binding]; other site 306537006190 putative aspartate binding site [chemical binding]; other site 306537006191 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 306537006192 putative allosteric regulatory site; other site 306537006193 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 306537006194 putative allosteric regulatory residue; other site 306537006195 2-isopropylmalate synthase; Validated; Region: PRK03739 306537006196 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 306537006197 active site 306537006198 catalytic residues [active] 306537006199 metal binding site [ion binding]; metal-binding site 306537006200 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 306537006201 DNA polymerase III subunit epsilon; Validated; Region: PRK05601 306537006202 DNA polymerase III subunit epsilon; Validated; Region: PRK05601 306537006203 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 306537006204 Low molecular weight phosphatase family; Region: LMWPc; cl00105 306537006205 active site 306537006206 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 306537006207 arsenical-resistance protein; Region: acr3; TIGR00832 306537006208 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 306537006209 dimerization interface [polypeptide binding]; other site 306537006210 putative DNA binding site [nucleotide binding]; other site 306537006211 putative Zn2+ binding site [ion binding]; other site 306537006212 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 306537006213 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 306537006214 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 306537006215 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 306537006216 conserved cys residue [active] 306537006217 Predicted membrane protein [Function unknown]; Region: COG4270 306537006218 recombination protein RecR; Reviewed; Region: recR; PRK00076 306537006219 RecR protein; Region: RecR; pfam02132 306537006220 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 306537006221 putative active site [active] 306537006222 putative metal-binding site [ion binding]; other site 306537006223 tetramer interface [polypeptide binding]; other site 306537006224 hypothetical protein; Validated; Region: PRK00153 306537006225 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 306537006226 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306537006227 Walker A motif; other site 306537006228 ATP binding site [chemical binding]; other site 306537006229 Walker B motif; other site 306537006230 arginine finger; other site 306537006231 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 306537006232 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 306537006233 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 306537006234 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 306537006235 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 306537006236 catalytic residue [active] 306537006237 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 306537006238 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 306537006239 oligomer interface [polypeptide binding]; other site 306537006240 metal binding site [ion binding]; metal-binding site 306537006241 metal binding site [ion binding]; metal-binding site 306537006242 putative Cl binding site [ion binding]; other site 306537006243 basic sphincter; other site 306537006244 hydrophobic gate; other site 306537006245 periplasmic entrance; other site 306537006246 Integrase core domain; Region: rve; pfam00665 306537006247 Integrase core domain; Region: rve_3; pfam13683 306537006248 enoyl-CoA hydratase; Provisional; Region: PRK07509 306537006249 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 306537006250 substrate binding site [chemical binding]; other site 306537006251 oxyanion hole (OAH) forming residues; other site 306537006252 trimer interface [polypeptide binding]; other site 306537006253 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 306537006254 active site 306537006255 HIGH motif; other site 306537006256 nucleotide binding site [chemical binding]; other site 306537006257 active site 306537006258 KMSKS motif; other site 306537006259 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 306537006260 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 306537006261 MMPL family; Region: MMPL; pfam03176 306537006262 MMPL family; Region: MMPL; pfam03176 306537006263 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 306537006264 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 306537006265 nucleoside/Zn binding site; other site 306537006266 dimer interface [polypeptide binding]; other site 306537006267 catalytic motif [active] 306537006268 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 306537006269 Prephenate dehydrogenase; Region: PDH; pfam02153 306537006270 prephenate dehydrogenase; Validated; Region: PRK08507 306537006271 prephenate dehydrogenase; Validated; Region: PRK08507 306537006272 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 306537006273 active site 306537006274 MULE transposase domain; Region: MULE; pfam10551 306537006275 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 306537006276 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 306537006277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306537006278 homodimer interface [polypeptide binding]; other site 306537006279 catalytic residue [active] 306537006280 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 306537006281 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 306537006282 NAD(P) binding site [chemical binding]; other site 306537006283 EamA-like transporter family; Region: EamA; pfam00892 306537006284 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 306537006285 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 306537006286 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 306537006287 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 306537006288 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 306537006289 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 306537006290 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 306537006291 Walker A/P-loop; other site 306537006292 ATP binding site [chemical binding]; other site 306537006293 Q-loop/lid; other site 306537006294 ABC transporter signature motif; other site 306537006295 Walker B; other site 306537006296 D-loop; other site 306537006297 H-loop/switch region; other site 306537006298 HicB family; Region: HicB; pfam05534 306537006299 Transposase, Mutator family; Region: Transposase_mut; pfam00872 306537006300 MULE transposase domain; Region: MULE; pfam10551 306537006301 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 306537006302 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 306537006303 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 306537006304 acyl-activating enzyme (AAE) consensus motif; other site 306537006305 putative AMP binding site [chemical binding]; other site 306537006306 putative active site [active] 306537006307 putative CoA binding site [chemical binding]; other site 306537006308 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 306537006309 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 306537006310 active site 306537006311 Predicted membrane protein [Function unknown]; Region: COG2246 306537006312 GtrA-like protein; Region: GtrA; pfam04138 306537006313 Predicted membrane protein [Function unknown]; Region: COG2246 306537006314 GtrA-like protein; Region: GtrA; pfam04138 306537006315 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 306537006316 FAD binding domain; Region: FAD_binding_4; pfam01565 306537006317 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 306537006318 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 306537006319 classical (c) SDRs; Region: SDR_c; cd05233 306537006320 NAD(P) binding site [chemical binding]; other site 306537006321 active site 306537006322 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 306537006323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306537006324 putative substrate translocation pore; other site 306537006325 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 306537006326 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 306537006327 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 306537006328 putative NAD(P) binding site [chemical binding]; other site 306537006329 dimer interface [polypeptide binding]; other site 306537006330 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 306537006331 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 306537006332 catalytic residues [active] 306537006333 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 306537006334 CoenzymeA binding site [chemical binding]; other site 306537006335 subunit interaction site [polypeptide binding]; other site 306537006336 PHB binding site; other site 306537006337 CrcB-like protein; Region: CRCB; pfam02537 306537006338 CrcB-like protein; Region: CRCB; cl09114 306537006339 CrcB-like protein; Region: CRCB; pfam02537 306537006340 Uncharacterized conserved protein [Function unknown]; Region: COG2353 306537006341 Transcriptional regulators [Transcription]; Region: MarR; COG1846 306537006342 MarR family; Region: MarR_2; pfam12802 306537006343 replicative DNA helicase; Provisional; Region: PRK05636 306537006344 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 306537006345 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 306537006346 Walker A motif; other site 306537006347 ATP binding site [chemical binding]; other site 306537006348 Walker B motif; other site 306537006349 DNA binding loops [nucleotide binding] 306537006350 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 306537006351 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 306537006352 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 306537006353 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 306537006354 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 306537006355 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 306537006356 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 306537006357 dimer interface [polypeptide binding]; other site 306537006358 ssDNA binding site [nucleotide binding]; other site 306537006359 tetramer (dimer of dimers) interface [polypeptide binding]; other site 306537006360 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 306537006361 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 306537006362 Predicted integral membrane protein [Function unknown]; Region: COG5650 306537006363 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 306537006364 Transglycosylase; Region: Transgly; pfam00912 306537006365 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 306537006366 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 306537006367 inositol 1-phosphate synthase, Actinobacterial type; Region: mycothiol_INO1; TIGR03450 306537006368 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 306537006369 MarR family; Region: MarR; pfam01047 306537006370 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 306537006371 Ligand Binding Site [chemical binding]; other site 306537006372 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 306537006373 Ligand Binding Site [chemical binding]; other site 306537006374 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 306537006375 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 306537006376 HIGH motif; other site 306537006377 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 306537006378 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 306537006379 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 306537006380 active site 306537006381 KMSKS motif; other site 306537006382 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 306537006383 tRNA binding surface [nucleotide binding]; other site 306537006384 SdpI/YhfL protein family; Region: SdpI; pfam13630 306537006385 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 306537006386 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 306537006387 substrate binding site [chemical binding]; other site 306537006388 dimer interface [polypeptide binding]; other site 306537006389 ATP binding site [chemical binding]; other site 306537006390 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 306537006391 active site 306537006392 tetramer interface [polypeptide binding]; other site 306537006393 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 306537006394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306537006395 putative substrate translocation pore; other site 306537006396 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 306537006397 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 306537006398 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 306537006399 nudix motif; other site 306537006400 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 306537006401 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 306537006402 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 306537006403 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 306537006404 active site 306537006405 NTP binding site [chemical binding]; other site 306537006406 metal binding triad [ion binding]; metal-binding site 306537006407 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 306537006408 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 306537006409 Zn2+ binding site [ion binding]; other site 306537006410 Mg2+ binding site [ion binding]; other site 306537006411 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 306537006412 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 306537006413 active site 306537006414 Ap6A binding site [chemical binding]; other site 306537006415 nudix motif; other site 306537006416 metal binding site [ion binding]; metal-binding site 306537006417 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 306537006418 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 306537006419 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 306537006420 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 306537006421 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 306537006422 DNA binding residues [nucleotide binding] 306537006423 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 306537006424 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 306537006425 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 306537006426 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 306537006427 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 306537006428 catalytic residues [active] 306537006429 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 306537006430 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 306537006431 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 306537006432 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 306537006433 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 306537006434 active site 306537006435 metal binding site [ion binding]; metal-binding site 306537006436 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370 306537006437 dimer interface [polypeptide binding]; other site 306537006438 FMN binding site [chemical binding]; other site 306537006439 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 306537006440 ParB-like nuclease domain; Region: ParBc; pfam02195 306537006441 KorB domain; Region: KorB; pfam08535 306537006442 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 306537006443 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 306537006444 P-loop; other site 306537006445 Magnesium ion binding site [ion binding]; other site 306537006446 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 306537006447 Magnesium ion binding site [ion binding]; other site 306537006448 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 306537006449 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 306537006450 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 306537006451 Haemolytic domain; Region: Haemolytic; pfam01809 306537006452 Ribonuclease P; Region: Ribonuclease_P; cl00457 306537006453 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399