-- dump date 20140619_051926 -- class Genbank::misc_feature -- table misc_feature_note -- id note 645127000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 645127000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645127000003 Walker A motif; other site 645127000004 ATP binding site [chemical binding]; other site 645127000005 Walker B motif; other site 645127000006 arginine finger; other site 645127000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 645127000008 DnaA box-binding interface [nucleotide binding]; other site 645127000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 645127000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 645127000011 putative DNA binding surface [nucleotide binding]; other site 645127000012 dimer interface [polypeptide binding]; other site 645127000013 beta-clamp/clamp loader binding surface; other site 645127000014 beta-clamp/translesion DNA polymerase binding surface; other site 645127000015 recombination protein F; Reviewed; Region: recF; PRK00064 645127000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 645127000017 Walker A/P-loop; other site 645127000018 ATP binding site [chemical binding]; other site 645127000019 Q-loop/lid; other site 645127000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645127000021 ABC transporter signature motif; other site 645127000022 Walker B; other site 645127000023 D-loop; other site 645127000024 H-loop/switch region; other site 645127000025 Protein of unknown function (DUF721); Region: DUF721; cl02324 645127000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 645127000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645127000028 ATP binding site [chemical binding]; other site 645127000029 Mg2+ binding site [ion binding]; other site 645127000030 G-X-G motif; other site 645127000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 645127000032 anchoring element; other site 645127000033 dimer interface [polypeptide binding]; other site 645127000034 ATP binding site [chemical binding]; other site 645127000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 645127000036 active site 645127000037 putative metal-binding site [ion binding]; other site 645127000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 645127000039 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 645127000040 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 645127000041 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 645127000042 active site 645127000043 metal binding site [ion binding]; metal-binding site 645127000044 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 645127000045 active site 645127000046 Mn binding site [ion binding]; other site 645127000047 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 645127000048 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 645127000049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645127000050 putative substrate translocation pore; other site 645127000051 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645127000052 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 645127000053 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 645127000054 active site 645127000055 substrate binding site [chemical binding]; other site 645127000056 FMN binding site [chemical binding]; other site 645127000057 putative catalytic residues [active] 645127000058 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 645127000059 L-lactate permease; Region: Lactate_perm; cl00701 645127000060 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 645127000061 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 645127000062 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 645127000063 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 645127000064 dimer interface [polypeptide binding]; other site 645127000065 putative radical transfer pathway; other site 645127000066 diiron center [ion binding]; other site 645127000067 tyrosyl radical; other site 645127000068 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 645127000069 Na2 binding site [ion binding]; other site 645127000070 putative substrate binding site 1 [chemical binding]; other site 645127000071 Na binding site 1 [ion binding]; other site 645127000072 putative substrate binding site 2 [chemical binding]; other site 645127000073 DNA gyrase subunit A; Validated; Region: PRK05560 645127000074 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 645127000075 CAP-like domain; other site 645127000076 active site 645127000077 primary dimer interface [polypeptide binding]; other site 645127000078 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 645127000079 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 645127000080 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 645127000081 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 645127000082 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 645127000083 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 645127000084 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 645127000085 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 645127000086 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 645127000087 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 645127000088 diphosphomevalonate decarboxylase; Region: PLN02407 645127000089 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 645127000090 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 645127000091 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 645127000092 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 645127000093 homotetramer interface [polypeptide binding]; other site 645127000094 FMN binding site [chemical binding]; other site 645127000095 homodimer contacts [polypeptide binding]; other site 645127000096 putative active site [active] 645127000097 putative substrate binding site [chemical binding]; other site 645127000098 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 645127000099 homodimer interface [polypeptide binding]; other site 645127000100 substrate binding pocket [chemical binding]; other site 645127000101 catalytic residues [active] 645127000102 NADH/NADPH cofactor binding site [chemical binding]; other site 645127000103 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 645127000104 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 645127000105 dimer interface [polypeptide binding]; other site 645127000106 active site 645127000107 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 645127000108 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 645127000109 active site 645127000110 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 645127000111 active site 645127000112 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 645127000113 Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723 645127000114 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 645127000115 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 645127000116 putative septation inhibitor protein; Reviewed; Region: PRK00159 645127000117 LssY C-terminus; Region: LssY_C; pfam14067 645127000118 oxaloacetate decarboxylase; Provisional; Region: PRK12330 645127000119 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 645127000120 active site 645127000121 catalytic residues [active] 645127000122 metal binding site [ion binding]; metal-binding site 645127000123 homodimer binding site [polypeptide binding]; other site 645127000124 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 645127000125 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 645127000126 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 645127000127 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 645127000128 putative homodimer interface [polypeptide binding]; other site 645127000129 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 645127000130 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 645127000131 carboxyltransferase (CT) interaction site; other site 645127000132 biotinylation site [posttranslational modification]; other site 645127000133 CsbD-like; Region: CsbD; pfam05532 645127000134 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 645127000135 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 645127000136 DNA binding site [nucleotide binding] 645127000137 active site 645127000138 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 645127000139 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 645127000140 active site 645127000141 dimer interface [polypeptide binding]; other site 645127000142 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 645127000143 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 645127000144 active site 645127000145 FMN binding site [chemical binding]; other site 645127000146 substrate binding site [chemical binding]; other site 645127000147 3Fe-4S cluster binding site [ion binding]; other site 645127000148 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 645127000149 domain interface; other site 645127000150 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 645127000151 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 645127000152 malonic semialdehyde reductase; Provisional; Region: PRK05365 645127000153 FMN binding site [chemical binding]; other site 645127000154 dimer interface [polypeptide binding]; other site 645127000155 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645127000156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645127000157 putative substrate translocation pore; other site 645127000158 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 645127000159 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 645127000160 Walker A/P-loop; other site 645127000161 ATP binding site [chemical binding]; other site 645127000162 Q-loop/lid; other site 645127000163 ABC transporter signature motif; other site 645127000164 Walker B; other site 645127000165 D-loop; other site 645127000166 H-loop/switch region; other site 645127000167 SdpI/YhfL protein family; Region: SdpI; pfam13630 645127000168 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 645127000169 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 645127000170 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 645127000171 Walker A/P-loop; other site 645127000172 ATP binding site [chemical binding]; other site 645127000173 Q-loop/lid; other site 645127000174 ABC transporter signature motif; other site 645127000175 Walker B; other site 645127000176 D-loop; other site 645127000177 H-loop/switch region; other site 645127000178 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 645127000179 RNA binding surface [nucleotide binding]; other site 645127000180 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 645127000181 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 645127000182 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 645127000183 Bacterial sugar transferase; Region: Bac_transf; pfam02397 645127000184 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 645127000185 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 645127000186 substrate binding site; other site 645127000187 tetramer interface; other site 645127000188 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 645127000189 trimer interface [polypeptide binding]; other site 645127000190 active site 645127000191 substrate binding site [chemical binding]; other site 645127000192 CoA binding site [chemical binding]; other site 645127000193 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 645127000194 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 645127000195 Chain length determinant protein; Region: Wzz; cl15801 645127000196 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 645127000197 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 645127000198 Low molecular weight phosphatase family; Region: LMWPc; cl00105 645127000199 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 645127000200 active site 645127000201 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 645127000202 putative active site [active] 645127000203 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 645127000204 HPr interaction site; other site 645127000205 glycerol kinase (GK) interaction site [polypeptide binding]; other site 645127000206 active site 645127000207 phosphorylation site [posttranslational modification] 645127000208 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 645127000209 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 645127000210 active site turn [active] 645127000211 phosphorylation site [posttranslational modification] 645127000212 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 645127000213 MMPL family; Region: MMPL; pfam03176 645127000214 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 645127000215 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 645127000216 active site 645127000217 Zn binding site [ion binding]; other site 645127000218 Protease prsW family; Region: PrsW-protease; pfam13367 645127000219 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 645127000220 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 645127000221 active site 645127000222 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 645127000223 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 645127000224 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 645127000225 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 645127000226 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 645127000227 LabA_like proteins; Region: LabA_like; cd06167 645127000228 putative metal binding site [ion binding]; other site 645127000229 Uncharacterized conserved protein [Function unknown]; Region: COG1432 645127000230 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 645127000231 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 645127000232 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 645127000233 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 645127000234 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 645127000235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645127000236 dimer interface [polypeptide binding]; other site 645127000237 conserved gate region; other site 645127000238 putative PBP binding loops; other site 645127000239 ABC-ATPase subunit interface; other site 645127000240 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 645127000241 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 645127000242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645127000243 dimer interface [polypeptide binding]; other site 645127000244 conserved gate region; other site 645127000245 putative PBP binding loops; other site 645127000246 ABC-ATPase subunit interface; other site 645127000247 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 645127000248 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 645127000249 Walker A/P-loop; other site 645127000250 ATP binding site [chemical binding]; other site 645127000251 Q-loop/lid; other site 645127000252 ABC transporter signature motif; other site 645127000253 Walker B; other site 645127000254 D-loop; other site 645127000255 H-loop/switch region; other site 645127000256 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 645127000257 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 645127000258 Walker A/P-loop; other site 645127000259 ATP binding site [chemical binding]; other site 645127000260 Q-loop/lid; other site 645127000261 ABC transporter signature motif; other site 645127000262 Walker B; other site 645127000263 D-loop; other site 645127000264 H-loop/switch region; other site 645127000265 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 645127000266 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 645127000267 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 645127000268 FtsX-like permease family; Region: FtsX; pfam02687 645127000269 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 645127000270 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 645127000271 FtsX-like permease family; Region: FtsX; pfam02687 645127000272 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 645127000273 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 645127000274 Walker A/P-loop; other site 645127000275 ATP binding site [chemical binding]; other site 645127000276 Q-loop/lid; other site 645127000277 ABC transporter signature motif; other site 645127000278 Walker B; other site 645127000279 D-loop; other site 645127000280 H-loop/switch region; other site 645127000281 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 645127000282 active site 645127000283 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 645127000284 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 645127000285 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 645127000286 Ligand Binding Site [chemical binding]; other site 645127000287 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 645127000288 Ligand Binding Site [chemical binding]; other site 645127000289 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645127000290 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645127000291 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 645127000292 active site 645127000293 catalytic site [active] 645127000294 putative inner membrane protein translocase component YidC; Validated; Region: PRK00247 645127000295 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 645127000296 Domain of unknown function (DUF2020); Region: DUF2020; pfam09449 645127000297 Lsr2; Region: Lsr2; pfam11774 645127000298 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 645127000299 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 645127000300 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 645127000301 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 645127000302 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 645127000303 methionine sulfoxide reductase A; Provisional; Region: PRK00058 645127000304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645127000305 putative substrate translocation pore; other site 645127000306 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645127000307 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 645127000308 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 645127000309 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 645127000310 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 645127000311 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 645127000312 tetramer (dimer of dimers) interface [polypeptide binding]; other site 645127000313 NAD binding site [chemical binding]; other site 645127000314 dimer interface [polypeptide binding]; other site 645127000315 substrate binding site [chemical binding]; other site 645127000316 pyruvate kinase; Provisional; Region: PRK14725 645127000317 active site 645127000318 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 645127000319 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 645127000320 active site 645127000321 catalytic site [active] 645127000322 Transcriptional regulator [Transcription]; Region: LytR; COG1316 645127000323 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 645127000324 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 645127000325 CAAX protease self-immunity; Region: Abi; pfam02517 645127000326 Amidase; Region: Amidase; cl11426 645127000327 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 645127000328 Prephenate dehydratase; Region: PDT; pfam00800 645127000329 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 645127000330 putative L-Phe binding site [chemical binding]; other site 645127000331 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 645127000332 catalytic core [active] 645127000333 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 645127000334 Glutamine amidotransferase class-I; Region: GATase; pfam00117 645127000335 glutamine binding [chemical binding]; other site 645127000336 catalytic triad [active] 645127000337 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 645127000338 Catalytic domain of Protein Kinases; Region: PKc; cd00180 645127000339 active site 645127000340 ATP binding site [chemical binding]; other site 645127000341 substrate binding site [chemical binding]; other site 645127000342 activation loop (A-loop); other site 645127000343 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 645127000344 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 645127000345 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 645127000346 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 645127000347 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 645127000348 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 645127000349 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 645127000350 active site 645127000351 ATP binding site [chemical binding]; other site 645127000352 substrate binding site [chemical binding]; other site 645127000353 activation loop (A-loop); other site 645127000354 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 645127000355 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 645127000356 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 645127000357 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 645127000358 Protein phosphatase 2C; Region: PP2C; pfam00481 645127000359 active site 645127000360 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 645127000361 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 645127000362 phosphopeptide binding site; other site 645127000363 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 645127000364 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 645127000365 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 645127000366 phosphopeptide binding site; other site 645127000367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645127000368 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 645127000369 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 645127000370 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 645127000371 ethanolamine permease; Region: 2A0305; TIGR00908 645127000372 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 645127000373 nudix motif; other site 645127000374 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 645127000375 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 645127000376 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 645127000377 NAD(P) binding site [chemical binding]; other site 645127000378 catalytic residues [active] 645127000379 Predicted membrane protein [Function unknown]; Region: COG4270 645127000380 recombination protein RecR; Reviewed; Region: recR; PRK00076 645127000381 RecR protein; Region: RecR; pfam02132 645127000382 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 645127000383 putative active site [active] 645127000384 putative metal-binding site [ion binding]; other site 645127000385 tetramer interface [polypeptide binding]; other site 645127000386 hypothetical protein; Validated; Region: PRK00153 645127000387 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 645127000388 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645127000389 Walker A motif; other site 645127000390 ATP binding site [chemical binding]; other site 645127000391 Walker B motif; other site 645127000392 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 645127000393 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 645127000394 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 645127000395 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645127000396 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645127000397 homodimer interface [polypeptide binding]; other site 645127000398 catalytic residue [active] 645127000399 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 645127000400 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 645127000401 dimerization domain swap beta strand [polypeptide binding]; other site 645127000402 regulatory protein interface [polypeptide binding]; other site 645127000403 active site 645127000404 regulatory phosphorylation site [posttranslational modification]; other site 645127000405 DAK2 domain; Region: Dak2; cl03685 645127000406 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 645127000407 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 645127000408 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 645127000409 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 645127000410 active site residue [active] 645127000411 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 645127000412 active site 645127000413 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 645127000414 substrate binding sites [chemical binding]; other site 645127000415 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 645127000416 CPxP motif; other site 645127000417 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 645127000418 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 645127000419 active site 645127000420 P-loop; other site 645127000421 phosphorylation site [posttranslational modification] 645127000422 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 645127000423 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 645127000424 active site 645127000425 phosphorylation site [posttranslational modification] 645127000426 BCCT family transporter; Region: BCCT; pfam02028 645127000427 GntP family permease; Region: GntP_permease; pfam02447 645127000428 fructuronate transporter; Provisional; Region: PRK10034; cl15264 645127000429 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 645127000430 AAA domain; Region: AAA_33; pfam13671 645127000431 ATP-binding site [chemical binding]; other site 645127000432 Gluconate-6-phosphate binding site [chemical binding]; other site 645127000433 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 645127000434 active site 645127000435 HIGH motif; other site 645127000436 nucleotide binding site [chemical binding]; other site 645127000437 active site 645127000438 KMSKS motif; other site 645127000439 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 645127000440 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 645127000441 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 645127000442 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645127000443 S-adenosylmethionine binding site [chemical binding]; other site 645127000444 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 645127000445 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645127000446 S-adenosylmethionine binding site [chemical binding]; other site 645127000447 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 645127000448 FAD binding domain; Region: FAD_binding_4; pfam01565 645127000449 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 645127000450 catalytic triad [active] 645127000451 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 645127000452 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 645127000453 DNA polymerase III subunit epsilon; Validated; Region: PRK05601 645127000454 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 645127000455 active site 645127000456 substrate binding site [chemical binding]; other site 645127000457 short chain dehydrogenase; Provisional; Region: PRK08267 645127000458 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 645127000459 NAD(P) binding site [chemical binding]; other site 645127000460 active site 645127000461 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 645127000462 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 645127000463 NAD(P) binding site [chemical binding]; other site 645127000464 catalytic residues [active] 645127000465 2-isopropylmalate synthase; Validated; Region: PRK03739 645127000466 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 645127000467 active site 645127000468 catalytic residues [active] 645127000469 metal binding site [ion binding]; metal-binding site 645127000470 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 645127000471 aspartate kinase; Reviewed; Region: PRK06635 645127000472 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 645127000473 putative nucleotide binding site [chemical binding]; other site 645127000474 putative catalytic residues [active] 645127000475 putative Mg ion binding site [ion binding]; other site 645127000476 putative aspartate binding site [chemical binding]; other site 645127000477 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 645127000478 putative allosteric regulatory site; other site 645127000479 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 645127000480 putative allosteric regulatory residue; other site 645127000481 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 645127000482 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 645127000483 RNA polymerase sigma factor; Provisional; Region: PRK12535 645127000484 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 645127000485 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 645127000486 DNA binding residues [nucleotide binding] 645127000487 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 645127000488 Catalases are antioxidant enzymes that catalyse the conversion of hydrogen peroxide to water and molecular oxygen, serving to protect cells from its toxic effects; Region: Catalase; smart01060 645127000489 heme binding pocket [chemical binding]; other site 645127000490 Catalase-related immune-responsive; Region: Catalase-rel; pfam06628 645127000491 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 645127000492 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 645127000493 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645127000494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645127000495 homodimer interface [polypeptide binding]; other site 645127000496 catalytic residue [active] 645127000497 Predicted membrane protein [Function unknown]; Region: COG1297 645127000498 putative oligopeptide transporter, OPT family; Region: TIGR00733 645127000499 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 645127000500 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 645127000501 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 645127000502 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 645127000503 active site 645127000504 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 645127000505 prephenate dehydrogenase; Validated; Region: PRK08507 645127000506 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 645127000507 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 645127000508 nucleoside/Zn binding site; other site 645127000509 dimer interface [polypeptide binding]; other site 645127000510 catalytic motif [active] 645127000511 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645127000512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645127000513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645127000514 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 645127000515 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 645127000516 active site 645127000517 TDP-binding site; other site 645127000518 acceptor substrate-binding pocket; other site 645127000519 homodimer interface [polypeptide binding]; other site 645127000520 Condensation domain; Region: Condensation; pfam00668 645127000521 peptide synthase; Provisional; Region: PRK12316 645127000522 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 645127000523 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 645127000524 trimer interface [polypeptide binding]; other site 645127000525 putative metal binding site [ion binding]; other site 645127000526 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 645127000527 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 645127000528 NAD(P) binding site [chemical binding]; other site 645127000529 active site 645127000530 hypothetical protein; Provisional; Region: PRK06062 645127000531 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 645127000532 inhibitor-cofactor binding pocket; inhibition site 645127000533 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645127000534 catalytic residue [active] 645127000535 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 645127000536 Septum formation; Region: Septum_form; pfam13845 645127000537 Septum formation; Region: Septum_form; pfam13845 645127000538 seryl-tRNA synthetase; Provisional; Region: PRK05431 645127000539 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 645127000540 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 645127000541 dimer interface [polypeptide binding]; other site 645127000542 active site 645127000543 motif 1; other site 645127000544 motif 2; other site 645127000545 motif 3; other site 645127000546 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 645127000547 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 645127000548 glycerol kinase; Provisional; Region: glpK; PRK00047 645127000549 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 645127000550 N- and C-terminal domain interface [polypeptide binding]; other site 645127000551 active site 645127000552 MgATP binding site [chemical binding]; other site 645127000553 catalytic site [active] 645127000554 metal binding site [ion binding]; metal-binding site 645127000555 putative homotetramer interface [polypeptide binding]; other site 645127000556 glycerol binding site [chemical binding]; other site 645127000557 homodimer interface [polypeptide binding]; other site 645127000558 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 645127000559 amphipathic channel; other site 645127000560 Asn-Pro-Ala signature motifs; other site 645127000561 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 645127000562 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 645127000563 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 645127000564 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 645127000565 putative acyl-acceptor binding pocket; other site 645127000566 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645127000567 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 645127000568 active site 645127000569 motif I; other site 645127000570 motif II; other site 645127000571 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 645127000572 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 645127000573 active site 645127000574 motif I; other site 645127000575 motif II; other site 645127000576 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645127000577 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 645127000578 active site 645127000579 catalytic residues [active] 645127000580 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 645127000581 putative transporter; Provisional; Region: PRK10484 645127000582 Na binding site [ion binding]; other site 645127000583 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 645127000584 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 645127000585 dimer interface [polypeptide binding]; other site 645127000586 active site 645127000587 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 645127000588 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 645127000589 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 645127000590 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 645127000591 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 645127000592 UDP-galactopyranose mutase; Region: GLF; pfam03275 645127000593 choline dehydrogenase; Validated; Region: PRK02106 645127000594 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 645127000595 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 645127000596 BCCT family transporter; Region: BCCT; cl00569 645127000597 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 645127000598 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 645127000599 NAD(P) binding site [chemical binding]; other site 645127000600 catalytic residues [active] 645127000601 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 645127000602 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 645127000603 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 645127000604 active site turn [active] 645127000605 phosphorylation site [posttranslational modification] 645127000606 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 645127000607 HPr interaction site; other site 645127000608 glycerol kinase (GK) interaction site [polypeptide binding]; other site 645127000609 active site 645127000610 phosphorylation site [posttranslational modification] 645127000611 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 645127000612 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 645127000613 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 645127000614 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 645127000615 PAP2 superfamily; Region: PAP2; pfam01569 645127000616 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 645127000617 active site 645127000618 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 645127000619 Putative esterase; Region: Esterase; pfam00756 645127000620 S-formylglutathione hydrolase; Region: PLN02442 645127000621 Putative esterase; Region: Esterase; pfam00756 645127000622 LGFP repeat; Region: LGFP; pfam08310 645127000623 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 645127000624 LGFP repeat; Region: LGFP; pfam08310 645127000625 LGFP repeat; Region: LGFP; pfam08310 645127000626 LGFP repeat; Region: LGFP; pfam08310 645127000627 Cutinase; Region: Cutinase; pfam01083 645127000628 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 645127000629 Predicted integral membrane protein [Function unknown]; Region: COG0392 645127000630 LabA_like proteins; Region: LabA_like; cd06167 645127000631 putative metal binding site [ion binding]; other site 645127000632 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645127000633 S-adenosylmethionine binding site [chemical binding]; other site 645127000634 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 645127000635 active site 645127000636 substrate-binding site [chemical binding]; other site 645127000637 metal-binding site [ion binding] 645127000638 GTP binding site [chemical binding]; other site 645127000639 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 645127000640 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 645127000641 Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251 645127000642 substrate binding [chemical binding]; other site 645127000643 Predicted membrane protein [Function unknown]; Region: COG1289 645127000644 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 645127000645 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 645127000646 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 645127000647 substrate binding site [chemical binding]; other site 645127000648 oxyanion hole (OAH) forming residues; other site 645127000649 trimer interface [polypeptide binding]; other site 645127000650 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 645127000651 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 645127000652 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 645127000653 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 645127000654 dimer interface [polypeptide binding]; other site 645127000655 active site 645127000656 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 645127000657 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 645127000658 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 645127000659 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 645127000660 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 645127000661 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 645127000662 Ligand Binding Site [chemical binding]; other site 645127000663 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 645127000664 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 645127000665 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 645127000666 VanW like protein; Region: VanW; pfam04294 645127000667 Protease prsW family; Region: PrsW-protease; pfam13367 645127000668 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 645127000669 active site 645127000670 benzoate transport; Region: 2A0115; TIGR00895 645127000671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645127000672 putative substrate translocation pore; other site 645127000673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645127000674 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 645127000675 trimer interface [polypeptide binding]; other site 645127000676 active site 645127000677 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 645127000678 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 645127000679 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 645127000680 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 645127000681 YibE/F-like protein; Region: YibE_F; pfam07907 645127000682 aminotransferase AlaT; Validated; Region: PRK09265 645127000683 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645127000684 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645127000685 homodimer interface [polypeptide binding]; other site 645127000686 catalytic residue [active] 645127000687 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 645127000688 Protein of unknown function, DUF488; Region: DUF488; cl01246 645127000689 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 645127000690 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 645127000691 nucleotide binding site [chemical binding]; other site 645127000692 NEF interaction site [polypeptide binding]; other site 645127000693 SBD interface [polypeptide binding]; other site 645127000694 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 645127000695 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 645127000696 dimer interface [polypeptide binding]; other site 645127000697 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 645127000698 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 645127000699 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 645127000700 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 645127000701 HSP70 interaction site [polypeptide binding]; other site 645127000702 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 645127000703 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 645127000704 Zn binding sites [ion binding]; other site 645127000705 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 645127000706 dimer interface [polypeptide binding]; other site 645127000707 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 645127000708 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 645127000709 DNA binding residues [nucleotide binding] 645127000710 putative dimer interface [polypeptide binding]; other site 645127000711 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 645127000712 FAD binding pocket [chemical binding]; other site 645127000713 conserved FAD binding motif [chemical binding]; other site 645127000714 phosphate binding motif [ion binding]; other site 645127000715 beta-alpha-beta structure motif; other site 645127000716 NAD binding pocket [chemical binding]; other site 645127000717 pyruvate carboxylase; Reviewed; Region: PRK12999 645127000718 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 645127000719 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 645127000720 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 645127000721 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 645127000722 active site 645127000723 catalytic residues [active] 645127000724 metal binding site [ion binding]; metal-binding site 645127000725 homodimer binding site [polypeptide binding]; other site 645127000726 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 645127000727 carboxyltransferase (CT) interaction site; other site 645127000728 biotinylation site [posttranslational modification]; other site 645127000729 Proline dehydrogenase; Region: Pro_dh; cl03282 645127000730 Delta 1-pyrroline-5-carboxylate dehydrogenase [Energy production and conversion]; Region: COG4230 645127000731 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 645127000732 NAD(P) binding site [chemical binding]; other site 645127000733 catalytic residues [active] 645127000734 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 645127000735 hypothetical protein; Provisional; Region: PRK10621 645127000736 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 645127000737 Predicted amidohydrolase [General function prediction only]; Region: COG0388 645127000738 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 645127000739 putative active site [active] 645127000740 catalytic triad [active] 645127000741 putative dimer interface [polypeptide binding]; other site 645127000742 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 645127000743 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645127000744 Walker A/P-loop; other site 645127000745 ATP binding site [chemical binding]; other site 645127000746 Q-loop/lid; other site 645127000747 ABC transporter signature motif; other site 645127000748 Walker B; other site 645127000749 D-loop; other site 645127000750 H-loop/switch region; other site 645127000751 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 645127000752 Clp amino terminal domain; Region: Clp_N; pfam02861 645127000753 Clp amino terminal domain; Region: Clp_N; pfam02861 645127000754 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645127000755 Walker A motif; other site 645127000756 ATP binding site [chemical binding]; other site 645127000757 Walker B motif; other site 645127000758 arginine finger; other site 645127000759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645127000760 Walker A motif; other site 645127000761 ATP binding site [chemical binding]; other site 645127000762 Walker B motif; other site 645127000763 arginine finger; other site 645127000764 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 645127000765 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 645127000766 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645127000767 Walker A/P-loop; other site 645127000768 ATP binding site [chemical binding]; other site 645127000769 Q-loop/lid; other site 645127000770 ABC transporter signature motif; other site 645127000771 Walker B; other site 645127000772 D-loop; other site 645127000773 H-loop/switch region; other site 645127000774 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 645127000775 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 645127000776 active site residue [active] 645127000777 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 645127000778 active site residue [active] 645127000779 glycine dehydrogenase; Provisional; Region: PRK05367 645127000780 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 645127000781 tetramer interface [polypeptide binding]; other site 645127000782 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645127000783 catalytic residue [active] 645127000784 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 645127000785 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 645127000786 catalytic residue [active] 645127000787 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 645127000788 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 645127000789 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 645127000790 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 645127000791 lipoyl attachment site [posttranslational modification]; other site 645127000792 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 645127000793 active site 645127000794 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 645127000795 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 645127000796 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 645127000797 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 645127000798 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 645127000799 DNA binding residues [nucleotide binding] 645127000800 putative dimer interface [polypeptide binding]; other site 645127000801 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 645127000802 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 645127000803 active site 645127000804 catalytic tetrad [active] 645127000805 T5orf172 domain; Region: T5orf172; pfam10544 645127000806 DEAD-like helicases superfamily; Region: DEXDc; smart00487 645127000807 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 645127000808 ATP binding site [chemical binding]; other site 645127000809 putative Mg++ binding site [ion binding]; other site 645127000810 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 645127000811 Methyltransferase domain; Region: Methyltransf_26; pfam13659 645127000812 Divergent AAA domain; Region: AAA_4; pfam04326 645127000813 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 645127000814 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 645127000815 Predicted membrane protein [Function unknown]; Region: COG4129 645127000816 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 645127000817 Transcription factor WhiB; Region: Whib; pfam02467 645127000818 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 645127000819 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 645127000820 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 645127000821 DNA binding residues [nucleotide binding] 645127000822 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 645127000823 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 645127000824 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 645127000825 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 645127000826 active site 645127000827 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 645127000828 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 645127000829 phosphate binding site [ion binding]; other site 645127000830 GMP synthase; Reviewed; Region: guaA; PRK00074 645127000831 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 645127000832 AMP/PPi binding site [chemical binding]; other site 645127000833 candidate oxyanion hole; other site 645127000834 catalytic triad [active] 645127000835 potential glutamine specificity residues [chemical binding]; other site 645127000836 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 645127000837 ATP Binding subdomain [chemical binding]; other site 645127000838 Ligand Binding sites [chemical binding]; other site 645127000839 Dimerization subdomain; other site 645127000840 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 645127000841 DNA Polymerase Y-family; Region: PolY_like; cd03468 645127000842 active site 645127000843 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 645127000844 DNA binding site [nucleotide binding] 645127000845 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 645127000846 putative dimer interface [polypeptide binding]; other site 645127000847 putative [2Fe-2S] cluster binding site [ion binding]; other site 645127000848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645127000849 ABC-ATPase subunit interface; other site 645127000850 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 645127000851 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 645127000852 Walker A/P-loop; other site 645127000853 ATP binding site [chemical binding]; other site 645127000854 Q-loop/lid; other site 645127000855 ABC transporter signature motif; other site 645127000856 Walker B; other site 645127000857 D-loop; other site 645127000858 H-loop/switch region; other site 645127000859 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 645127000860 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 645127000861 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 645127000862 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 645127000863 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 645127000864 active site 645127000865 PHP Thumb interface [polypeptide binding]; other site 645127000866 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 645127000867 generic binding surface II; other site 645127000868 generic binding surface I; other site 645127000869 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 645127000870 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 645127000871 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 645127000872 NAD(P) binding site [chemical binding]; other site 645127000873 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 645127000874 NAD(P) binding site [chemical binding]; other site 645127000875 active site 645127000876 active site 645127000877 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 645127000878 Clp amino terminal domain; Region: Clp_N; pfam02861 645127000879 Clp amino terminal domain; Region: Clp_N; pfam02861 645127000880 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645127000881 Walker A motif; other site 645127000882 ATP binding site [chemical binding]; other site 645127000883 Walker B motif; other site 645127000884 arginine finger; other site 645127000885 UvrB/uvrC motif; Region: UVR; pfam02151 645127000886 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645127000887 Walker A motif; other site 645127000888 ATP binding site [chemical binding]; other site 645127000889 Walker B motif; other site 645127000890 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 645127000891 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 645127000892 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 645127000893 minor groove reading motif; other site 645127000894 helix-hairpin-helix signature motif; other site 645127000895 active site 645127000896 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 645127000897 active site clefts [active] 645127000898 zinc binding site [ion binding]; other site 645127000899 dimer interface [polypeptide binding]; other site 645127000900 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 645127000901 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 645127000902 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 645127000903 active site 645127000904 HIGH motif; other site 645127000905 nucleotide binding site [chemical binding]; other site 645127000906 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 645127000907 KMSKS motif; other site 645127000908 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 645127000909 tRNA binding surface [nucleotide binding]; other site 645127000910 anticodon binding site; other site 645127000911 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 645127000912 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 645127000913 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 645127000914 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 645127000915 dimer interface [polypeptide binding]; other site 645127000916 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 645127000917 putative PBP binding regions; other site 645127000918 ABC-ATPase subunit interface; other site 645127000919 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 645127000920 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645127000921 Walker A/P-loop; other site 645127000922 ATP binding site [chemical binding]; other site 645127000923 Q-loop/lid; other site 645127000924 ABC transporter signature motif; other site 645127000925 Walker B; other site 645127000926 D-loop; other site 645127000927 H-loop/switch region; other site 645127000928 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 645127000929 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 645127000930 intersubunit interface [polypeptide binding]; other site 645127000931 Transcriptional regulators [Transcription]; Region: PurR; COG1609 645127000932 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 645127000933 DNA binding site [nucleotide binding] 645127000934 domain linker motif; other site 645127000935 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 645127000936 putative dimerization interface [polypeptide binding]; other site 645127000937 putative ligand binding site [chemical binding]; other site 645127000938 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 645127000939 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 645127000940 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 645127000941 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 645127000942 catalytic loop [active] 645127000943 iron binding site [ion binding]; other site 645127000944 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 645127000945 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 645127000946 active site 645127000947 homotetramer interface [polypeptide binding]; other site 645127000948 Transcriptional regulator [Transcription]; Region: LysR; COG0583 645127000949 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 645127000950 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 645127000951 putative dimerization interface [polypeptide binding]; other site 645127000952 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 645127000953 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 645127000954 gating phenylalanine in ion channel; other site 645127000955 Uncharacterized conserved protein [Function unknown]; Region: COG2966 645127000956 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 645127000957 Uncharacterized conserved protein [Function unknown]; Region: COG3610 645127000958 Abi-like protein; Region: Abi_2; pfam07751 645127000959 Haemolysin-III related; Region: HlyIII; pfam03006 645127000960 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 645127000961 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645127000962 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 645127000963 Walker A/P-loop; other site 645127000964 ATP binding site [chemical binding]; other site 645127000965 Q-loop/lid; other site 645127000966 ABC transporter signature motif; other site 645127000967 Walker B; other site 645127000968 D-loop; other site 645127000969 H-loop/switch region; other site 645127000970 ABC-2 type transporter; Region: ABC2_membrane; cl17235 645127000971 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 645127000972 Fructosamine kinase; Region: Fructosamin_kin; cl17579 645127000973 Phosphotransferase enzyme family; Region: APH; pfam01636 645127000974 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 645127000975 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 645127000976 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 645127000977 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645127000978 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645127000979 active site 645127000980 phosphorylation site [posttranslational modification] 645127000981 intermolecular recognition site; other site 645127000982 dimerization interface [polypeptide binding]; other site 645127000983 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645127000984 DNA binding site [nucleotide binding] 645127000985 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645127000986 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 645127000987 dimerization interface [polypeptide binding]; other site 645127000988 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645127000989 dimer interface [polypeptide binding]; other site 645127000990 phosphorylation site [posttranslational modification] 645127000991 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645127000992 ATP binding site [chemical binding]; other site 645127000993 Mg2+ binding site [ion binding]; other site 645127000994 G-X-G motif; other site 645127000995 PGAP1-like protein; Region: PGAP1; pfam07819 645127000996 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 645127000997 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 645127000998 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 645127000999 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 645127001000 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 645127001001 aspartate aminotransferase; Provisional; Region: PRK05764 645127001002 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645127001003 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645127001004 homodimer interface [polypeptide binding]; other site 645127001005 catalytic residue [active] 645127001006 adenylosuccinate lyase; Region: purB; TIGR00928 645127001007 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 645127001008 tetramer interface [polypeptide binding]; other site 645127001009 Predicted esterase [General function prediction only]; Region: COG0627 645127001010 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 645127001011 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 645127001012 ATP binding site [chemical binding]; other site 645127001013 active site 645127001014 substrate binding site [chemical binding]; other site 645127001015 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 645127001016 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 645127001017 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 645127001018 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645127001019 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 645127001020 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 645127001021 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 645127001022 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 645127001023 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 645127001024 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 645127001025 catalytic residues [active] 645127001026 dimer interface [polypeptide binding]; other site 645127001027 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 645127001028 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 645127001029 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 645127001030 putative active site [active] 645127001031 catalytic triad [active] 645127001032 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 645127001033 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 645127001034 dimerization interface [polypeptide binding]; other site 645127001035 ATP binding site [chemical binding]; other site 645127001036 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 645127001037 dimerization interface [polypeptide binding]; other site 645127001038 ATP binding site [chemical binding]; other site 645127001039 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 645127001040 active site 645127001041 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 645127001042 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 645127001043 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 645127001044 amidophosphoribosyltransferase; Provisional; Region: PRK07847 645127001045 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 645127001046 active site 645127001047 tetramer interface [polypeptide binding]; other site 645127001048 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 645127001049 active site 645127001050 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 645127001051 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 645127001052 dimerization interface [polypeptide binding]; other site 645127001053 putative ATP binding site [chemical binding]; other site 645127001054 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 645127001055 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 645127001056 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 645127001057 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 645127001058 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 645127001059 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 645127001060 homodimer interface [polypeptide binding]; other site 645127001061 substrate-cofactor binding pocket; other site 645127001062 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645127001063 catalytic residue [active] 645127001064 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 645127001065 FAD binding domain; Region: FAD_binding_4; pfam01565 645127001066 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 645127001067 Uncharacterized conserved protein [Function unknown]; Region: COG2353 645127001068 chaperone protein HchA; Provisional; Region: PRK04155 645127001069 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 645127001070 conserved cys residue [active] 645127001071 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 645127001072 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 645127001073 heme-binding site [chemical binding]; other site 645127001074 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 645127001075 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645127001076 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645127001077 DNA binding site [nucleotide binding] 645127001078 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 645127001079 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645127001080 Coenzyme A binding pocket [chemical binding]; other site 645127001081 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 645127001082 PBP superfamily domain; Region: PBP_like_2; cl17296 645127001083 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 645127001084 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645127001085 dimer interface [polypeptide binding]; other site 645127001086 conserved gate region; other site 645127001087 putative PBP binding loops; other site 645127001088 ABC-ATPase subunit interface; other site 645127001089 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 645127001090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645127001091 dimer interface [polypeptide binding]; other site 645127001092 conserved gate region; other site 645127001093 putative PBP binding loops; other site 645127001094 ABC-ATPase subunit interface; other site 645127001095 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 645127001096 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 645127001097 Walker A/P-loop; other site 645127001098 ATP binding site [chemical binding]; other site 645127001099 Q-loop/lid; other site 645127001100 ABC transporter signature motif; other site 645127001101 Walker B; other site 645127001102 D-loop; other site 645127001103 H-loop/switch region; other site 645127001104 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 645127001105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645127001106 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645127001107 putative substrate translocation pore; other site 645127001108 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 645127001109 PhoU domain; Region: PhoU; pfam01895 645127001110 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 645127001111 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 645127001112 FMN binding site [chemical binding]; other site 645127001113 active site 645127001114 catalytic residues [active] 645127001115 substrate binding site [chemical binding]; other site 645127001116 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 645127001117 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 645127001118 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 645127001119 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 645127001120 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 645127001121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645127001122 ABC-ATPase subunit interface; other site 645127001123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645127001124 dimer interface [polypeptide binding]; other site 645127001125 conserved gate region; other site 645127001126 putative PBP binding loops; other site 645127001127 ABC-ATPase subunit interface; other site 645127001128 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 645127001129 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645127001130 Walker A/P-loop; other site 645127001131 ATP binding site [chemical binding]; other site 645127001132 Q-loop/lid; other site 645127001133 ABC transporter signature motif; other site 645127001134 Walker B; other site 645127001135 D-loop; other site 645127001136 H-loop/switch region; other site 645127001137 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 645127001138 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 645127001139 active site 645127001140 catalytic site [active] 645127001141 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 645127001142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645127001143 putative substrate translocation pore; other site 645127001144 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 645127001145 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 645127001146 intersubunit interface [polypeptide binding]; other site 645127001147 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 645127001148 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 645127001149 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 645127001150 ABC-ATPase subunit interface; other site 645127001151 dimer interface [polypeptide binding]; other site 645127001152 putative PBP binding regions; other site 645127001153 proposed F420-0 ABC transporter, ATP-binding protein; Region: F420-0_ABC_ATP; TIGR03873 645127001154 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 645127001155 Walker A/P-loop; other site 645127001156 ATP binding site [chemical binding]; other site 645127001157 Q-loop/lid; other site 645127001158 ABC transporter signature motif; other site 645127001159 Walker B; other site 645127001160 D-loop; other site 645127001161 H-loop/switch region; other site 645127001162 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645127001163 Coenzyme A binding pocket [chemical binding]; other site 645127001164 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 645127001165 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 645127001166 trimer interface [polypeptide binding]; other site 645127001167 active site 645127001168 substrate binding site [chemical binding]; other site 645127001169 CoA binding site [chemical binding]; other site 645127001170 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 645127001171 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 645127001172 dimer interface [polypeptide binding]; other site 645127001173 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645127001174 catalytic residue [active] 645127001175 enoyl-CoA hydratase; Provisional; Region: PRK05862 645127001176 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 645127001177 substrate binding site [chemical binding]; other site 645127001178 oxyanion hole (OAH) forming residues; other site 645127001179 trimer interface [polypeptide binding]; other site 645127001180 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 645127001181 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 645127001182 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 645127001183 DNA binding residues [nucleotide binding] 645127001184 dimerization interface [polypeptide binding]; other site 645127001185 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 645127001186 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 645127001187 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 645127001188 hinge; other site 645127001189 active site 645127001190 aminotransferase; Validated; Region: PRK07777 645127001191 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645127001192 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645127001193 homodimer interface [polypeptide binding]; other site 645127001194 catalytic residue [active] 645127001195 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 645127001196 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 645127001197 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 645127001198 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 645127001199 ATP binding site [chemical binding]; other site 645127001200 putative Mg++ binding site [ion binding]; other site 645127001201 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645127001202 nucleotide binding region [chemical binding]; other site 645127001203 ATP-binding site [chemical binding]; other site 645127001204 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 645127001205 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 645127001206 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 645127001207 DNA-binding site [nucleotide binding]; DNA binding site 645127001208 RNA-binding motif; other site 645127001209 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 645127001210 H+ Antiporter protein; Region: 2A0121; TIGR00900 645127001211 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 645127001212 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 645127001213 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 645127001214 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 645127001215 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 645127001216 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 645127001217 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 645127001218 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 645127001219 catalytic residue [active] 645127001220 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 645127001221 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 645127001222 dimer interface [polypeptide binding]; other site 645127001223 active site 645127001224 citrylCoA binding site [chemical binding]; other site 645127001225 NADH binding [chemical binding]; other site 645127001226 cationic pore residues; other site 645127001227 oxalacetate/citrate binding site [chemical binding]; other site 645127001228 coenzyme A binding site [chemical binding]; other site 645127001229 catalytic triad [active] 645127001230 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 645127001231 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 645127001232 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 645127001233 dimerization interface [polypeptide binding]; other site 645127001234 putative DNA binding site [nucleotide binding]; other site 645127001235 putative Zn2+ binding site [ion binding]; other site 645127001236 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 645127001237 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 645127001238 Soluble P-type ATPase [General function prediction only]; Region: COG4087 645127001239 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 645127001240 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 645127001241 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 645127001242 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 645127001243 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 645127001244 active site 645127001245 catalytic tetrad [active] 645127001246 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 645127001247 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 645127001248 substrate binding site [chemical binding]; other site 645127001249 oxyanion hole (OAH) forming residues; other site 645127001250 trimer interface [polypeptide binding]; other site 645127001251 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 645127001252 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 645127001253 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 645127001254 Soluble P-type ATPase [General function prediction only]; Region: COG4087 645127001255 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 645127001256 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 645127001257 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 645127001258 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 645127001259 hydrophobic ligand binding site; other site 645127001260 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 645127001261 active site 645127001262 SAM binding site [chemical binding]; other site 645127001263 homodimer interface [polypeptide binding]; other site 645127001264 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 645127001265 catalytic residues [active] 645127001266 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 645127001267 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 645127001268 folate binding site [chemical binding]; other site 645127001269 NADP+ binding site [chemical binding]; other site 645127001270 thymidylate synthase; Reviewed; Region: thyA; PRK01827 645127001271 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 645127001272 dimerization interface [polypeptide binding]; other site 645127001273 active site 645127001274 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 645127001275 active site 645127001276 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 645127001277 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 645127001278 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 645127001279 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 645127001280 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 645127001281 siderophore binding site; other site 645127001282 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 645127001283 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 645127001284 Walker A/P-loop; other site 645127001285 ATP binding site [chemical binding]; other site 645127001286 Q-loop/lid; other site 645127001287 ABC transporter signature motif; other site 645127001288 Walker B; other site 645127001289 D-loop; other site 645127001290 H-loop/switch region; other site 645127001291 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 645127001292 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 645127001293 ABC-ATPase subunit interface; other site 645127001294 dimer interface [polypeptide binding]; other site 645127001295 putative PBP binding regions; other site 645127001296 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 645127001297 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 645127001298 ABC-ATPase subunit interface; other site 645127001299 dimer interface [polypeptide binding]; other site 645127001300 putative PBP binding regions; other site 645127001301 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 645127001302 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 645127001303 active site 645127001304 dimer interface [polypeptide binding]; other site 645127001305 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 645127001306 dimer interface [polypeptide binding]; other site 645127001307 active site 645127001308 hypothetical protein; Provisional; Region: PRK07857 645127001309 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 645127001310 Part of AAA domain; Region: AAA_19; pfam13245 645127001311 Family description; Region: UvrD_C_2; pfam13538 645127001312 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 645127001313 Peptidase family M23; Region: Peptidase_M23; pfam01551 645127001314 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 645127001315 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 645127001316 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 645127001317 active site 645127001318 substrate binding site [chemical binding]; other site 645127001319 cosubstrate binding site; other site 645127001320 catalytic site [active] 645127001321 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 645127001322 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 645127001323 purine monophosphate binding site [chemical binding]; other site 645127001324 dimer interface [polypeptide binding]; other site 645127001325 putative catalytic residues [active] 645127001326 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 645127001327 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 645127001328 putative acyltransferase; Provisional; Region: PRK05790 645127001329 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 645127001330 dimer interface [polypeptide binding]; other site 645127001331 active site 645127001332 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 645127001333 Predicted permeases [General function prediction only]; Region: COG0679 645127001334 30S ribosomal protein S18; Provisional; Region: PRK13401 645127001335 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 645127001336 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 645127001337 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 645127001338 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 645127001339 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 645127001340 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 645127001341 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 645127001342 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 645127001343 protein binding site [polypeptide binding]; other site 645127001344 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 645127001345 MPT binding site; other site 645127001346 trimer interface [polypeptide binding]; other site 645127001347 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 645127001348 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 645127001349 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 645127001350 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 645127001351 active site 645127001352 tetramer interface; other site 645127001353 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 645127001354 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 645127001355 dimer interface [polypeptide binding]; other site 645127001356 putative functional site; other site 645127001357 putative MPT binding site; other site 645127001358 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 645127001359 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 645127001360 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 645127001361 active site 645127001362 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645127001363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645127001364 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 645127001365 intracellular protease, PfpI family; Region: PfpI; TIGR01382 645127001366 proposed catalytic triad [active] 645127001367 conserved cys residue [active] 645127001368 Protein of unknown function (DUF805); Region: DUF805; pfam05656 645127001369 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645127001370 benzoate transport; Region: 2A0115; TIGR00895 645127001371 putative substrate translocation pore; other site 645127001372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645127001373 putative substrate translocation pore; other site 645127001374 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 645127001375 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 645127001376 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 645127001377 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 645127001378 siderophore binding site; other site 645127001379 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 645127001380 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645127001381 active site 645127001382 phosphorylation site [posttranslational modification] 645127001383 intermolecular recognition site; other site 645127001384 dimerization interface [polypeptide binding]; other site 645127001385 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 645127001386 DNA binding residues [nucleotide binding] 645127001387 Histidine kinase; Region: HisKA_3; pfam07730 645127001388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645127001389 ATP binding site [chemical binding]; other site 645127001390 Mg2+ binding site [ion binding]; other site 645127001391 G-X-G motif; other site 645127001392 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 645127001393 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 645127001394 Walker A/P-loop; other site 645127001395 ATP binding site [chemical binding]; other site 645127001396 Q-loop/lid; other site 645127001397 ABC transporter signature motif; other site 645127001398 Walker B; other site 645127001399 D-loop; other site 645127001400 H-loop/switch region; other site 645127001401 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 645127001402 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 645127001403 Predicted membrane protein [Function unknown]; Region: COG2259 645127001404 Predicted membrane protein [Function unknown]; Region: COG2259 645127001405 Predicted integral membrane protein [Function unknown]; Region: COG5660 645127001406 Putative zinc-finger; Region: zf-HC2; pfam13490 645127001407 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 645127001408 Predicted methyltransferases [General function prediction only]; Region: COG0313 645127001409 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 645127001410 putative SAM binding site [chemical binding]; other site 645127001411 putative homodimer interface [polypeptide binding]; other site 645127001412 BCCT family transporter; Region: BCCT; pfam02028 645127001413 Rrf2 family protein; Region: rrf2_super; TIGR00738 645127001414 Transcriptional regulator; Region: Rrf2; cl17282 645127001415 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 645127001416 chorismate binding enzyme; Region: Chorismate_bind; cl10555 645127001417 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 645127001418 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 645127001419 active site 645127001420 HIGH motif; other site 645127001421 KMSKS motif; other site 645127001422 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 645127001423 tRNA binding surface [nucleotide binding]; other site 645127001424 anticodon binding site; other site 645127001425 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 645127001426 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 645127001427 NADP binding site [chemical binding]; other site 645127001428 dimer interface [polypeptide binding]; other site 645127001429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645127001430 S-adenosylmethionine binding site [chemical binding]; other site 645127001431 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 645127001432 trimer interface [polypeptide binding]; other site 645127001433 active site 645127001434 G bulge; other site 645127001435 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 645127001436 trimer interface [polypeptide binding]; other site 645127001437 active site 645127001438 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 645127001439 active site 645127001440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 645127001441 Domain of unknown function (DUF348); Region: DUF348; pfam03990 645127001442 Domain of unknown function (DUF348); Region: DUF348; pfam03990 645127001443 Domain of unknown function (DUF348); Region: DUF348; pfam03990 645127001444 G5 domain; Region: G5; pfam07501 645127001445 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 645127001446 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 645127001447 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 645127001448 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 645127001449 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 645127001450 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 645127001451 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 645127001452 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 645127001453 Uncharacterized conserved protein [Function unknown]; Region: COG1359 645127001454 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 645127001455 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 645127001456 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 645127001457 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 645127001458 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 645127001459 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 645127001460 substrate binding site [chemical binding]; other site 645127001461 oxyanion hole (OAH) forming residues; other site 645127001462 trimer interface [polypeptide binding]; other site 645127001463 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 645127001464 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 645127001465 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 645127001466 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 645127001467 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 645127001468 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 645127001469 G1 box; other site 645127001470 putative GEF interaction site [polypeptide binding]; other site 645127001471 GTP/Mg2+ binding site [chemical binding]; other site 645127001472 Switch I region; other site 645127001473 G2 box; other site 645127001474 G3 box; other site 645127001475 Switch II region; other site 645127001476 G4 box; other site 645127001477 G5 box; other site 645127001478 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 645127001479 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 645127001480 FMN binding site [chemical binding]; other site 645127001481 substrate binding site [chemical binding]; other site 645127001482 putative catalytic residue [active] 645127001483 malate dehydrogenase; Provisional; Region: PRK13529 645127001484 Malic enzyme, N-terminal domain; Region: malic; pfam00390 645127001485 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 645127001486 NAD(P) binding site [chemical binding]; other site 645127001487 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 645127001488 putative active site [active] 645127001489 catalytic residue [active] 645127001490 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 645127001491 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 645127001492 5S rRNA interface [nucleotide binding]; other site 645127001493 CTC domain interface [polypeptide binding]; other site 645127001494 L16 interface [polypeptide binding]; other site 645127001495 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 645127001496 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 645127001497 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 645127001498 active site 645127001499 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 645127001500 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 645127001501 Substrate binding site; other site 645127001502 Mg++ binding site; other site 645127001503 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 645127001504 active site 645127001505 substrate binding site [chemical binding]; other site 645127001506 CoA binding site [chemical binding]; other site 645127001507 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645127001508 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645127001509 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 645127001510 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 645127001511 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 645127001512 ATP binding site [chemical binding]; other site 645127001513 putative Mg++ binding site [ion binding]; other site 645127001514 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645127001515 nucleotide binding region [chemical binding]; other site 645127001516 ATP-binding site [chemical binding]; other site 645127001517 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 645127001518 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 645127001519 homodimer interface [polypeptide binding]; other site 645127001520 metal binding site [ion binding]; metal-binding site 645127001521 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 645127001522 enolase; Provisional; Region: eno; PRK00077 645127001523 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 645127001524 dimer interface [polypeptide binding]; other site 645127001525 metal binding site [ion binding]; metal-binding site 645127001526 substrate binding pocket [chemical binding]; other site 645127001527 Septum formation initiator; Region: DivIC; pfam04977 645127001528 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 645127001529 Uncharacterized conserved protein [Function unknown]; Region: COG1507 645127001530 exopolyphosphatase; Region: exo_poly_only; TIGR03706 645127001531 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 645127001532 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 645127001533 Short repeat of unknown function (DUF308); Region: DUF308; pfam03729 645127001534 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 645127001535 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 645127001536 Bax inhibitor 1 like; Region: BaxI_1; cl17691 645127001537 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 645127001538 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 645127001539 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 645127001540 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 645127001541 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 645127001542 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 645127001543 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 645127001544 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 645127001545 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 645127001546 catalytic residue [active] 645127001547 putative FPP diphosphate binding site; other site 645127001548 putative FPP binding hydrophobic cleft; other site 645127001549 dimer interface [polypeptide binding]; other site 645127001550 putative IPP diphosphate binding site; other site 645127001551 pantothenate kinase; Provisional; Region: PRK05439 645127001552 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 645127001553 ATP-binding site [chemical binding]; other site 645127001554 CoA-binding site [chemical binding]; other site 645127001555 Mg2+-binding site [ion binding]; other site 645127001556 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 645127001557 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 645127001558 dimer interface [polypeptide binding]; other site 645127001559 active site 645127001560 glycine-pyridoxal phosphate binding site [chemical binding]; other site 645127001561 folate binding site [chemical binding]; other site 645127001562 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 645127001563 Isochorismatase family; Region: Isochorismatase; pfam00857 645127001564 catalytic triad [active] 645127001565 metal binding site [ion binding]; metal-binding site 645127001566 conserved cis-peptide bond; other site 645127001567 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 645127001568 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 645127001569 active site 645127001570 enoyl-CoA hydratase; Provisional; Region: PRK08140 645127001571 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 645127001572 substrate binding site [chemical binding]; other site 645127001573 oxyanion hole (OAH) forming residues; other site 645127001574 trimer interface [polypeptide binding]; other site 645127001575 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 645127001576 dimerization interface [polypeptide binding]; other site 645127001577 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 645127001578 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645127001579 Coenzyme A binding pocket [chemical binding]; other site 645127001580 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645127001581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 645127001582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645127001583 putative substrate translocation pore; other site 645127001584 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645127001585 fumarate hydratase; Reviewed; Region: fumC; PRK00485 645127001586 Class II fumarases; Region: Fumarase_classII; cd01362 645127001587 active site 645127001588 tetramer interface [polypeptide binding]; other site 645127001589 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 645127001590 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 645127001591 putative active site [active] 645127001592 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 645127001593 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 645127001594 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 645127001595 generic binding surface II; other site 645127001596 generic binding surface I; other site 645127001597 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 645127001598 Domain of unknown function DUF20; Region: UPF0118; pfam01594 645127001599 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 645127001600 Domain of unknown function DUF20; Region: UPF0118; pfam01594 645127001601 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 645127001602 Na2 binding site [ion binding]; other site 645127001603 putative substrate binding site 1 [chemical binding]; other site 645127001604 Na binding site 1 [ion binding]; other site 645127001605 putative substrate binding site 2 [chemical binding]; other site 645127001606 GTP-binding protein YchF; Reviewed; Region: PRK09601 645127001607 YchF GTPase; Region: YchF; cd01900 645127001608 G1 box; other site 645127001609 GTP/Mg2+ binding site [chemical binding]; other site 645127001610 Switch I region; other site 645127001611 G2 box; other site 645127001612 Switch II region; other site 645127001613 G3 box; other site 645127001614 G4 box; other site 645127001615 G5 box; other site 645127001616 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 645127001617 acetolactate synthase; Reviewed; Region: PRK08617 645127001618 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 645127001619 PYR/PP interface [polypeptide binding]; other site 645127001620 dimer interface [polypeptide binding]; other site 645127001621 TPP binding site [chemical binding]; other site 645127001622 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 645127001623 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 645127001624 TPP-binding site [chemical binding]; other site 645127001625 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 645127001626 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 645127001627 active site 645127001628 catalytic tetrad [active] 645127001629 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645127001630 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645127001631 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 645127001632 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 645127001633 active site 645127001634 catalytic tetrad [active] 645127001635 glutamate dehydrogenase; Provisional; Region: PRK09414 645127001636 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 645127001637 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 645127001638 NAD(P) binding site [chemical binding]; other site 645127001639 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 645127001640 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 645127001641 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 645127001642 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 645127001643 Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755 645127001644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645127001645 putative substrate translocation pore; other site 645127001646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645127001647 putative substrate translocation pore; other site 645127001648 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645127001649 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 645127001650 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 645127001651 active site 645127001652 nucleophile elbow; other site 645127001653 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 645127001654 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 645127001655 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 645127001656 Walker A/P-loop; other site 645127001657 ATP binding site [chemical binding]; other site 645127001658 Q-loop/lid; other site 645127001659 ABC transporter signature motif; other site 645127001660 Walker B; other site 645127001661 D-loop; other site 645127001662 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 645127001663 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 645127001664 Walker A/P-loop; other site 645127001665 ATP binding site [chemical binding]; other site 645127001666 Q-loop/lid; other site 645127001667 ABC transporter signature motif; other site 645127001668 Walker B; other site 645127001669 D-loop; other site 645127001670 H-loop/switch region; other site 645127001671 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 645127001672 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645127001673 hypothetical protein; Provisional; Region: PRK06547 645127001674 Walker A/P-loop; other site 645127001675 ATP binding site [chemical binding]; other site 645127001676 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 645127001677 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 645127001678 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 645127001679 FAD binding site [chemical binding]; other site 645127001680 homotetramer interface [polypeptide binding]; other site 645127001681 substrate binding pocket [chemical binding]; other site 645127001682 catalytic base [active] 645127001683 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 645127001684 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 645127001685 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 645127001686 Potassium binding sites [ion binding]; other site 645127001687 Cesium cation binding sites [ion binding]; other site 645127001688 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 645127001689 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 645127001690 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 645127001691 Protein of unknown function (DUF402); Region: DUF402; cl00979 645127001692 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 645127001693 metal ion-dependent adhesion site (MIDAS); other site 645127001694 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 645127001695 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645127001696 Walker A motif; other site 645127001697 ATP binding site [chemical binding]; other site 645127001698 Walker B motif; other site 645127001699 arginine finger; other site 645127001700 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 645127001701 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 645127001702 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 645127001703 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 645127001704 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 645127001705 G1 box; other site 645127001706 GTP/Mg2+ binding site [chemical binding]; other site 645127001707 G2 box; other site 645127001708 Switch I region; other site 645127001709 G3 box; other site 645127001710 Switch II region; other site 645127001711 G4 box; other site 645127001712 G5 box; other site 645127001713 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 645127001714 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 645127001715 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 645127001716 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 645127001717 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 645127001718 Ferredoxin [Energy production and conversion]; Region: COG1146 645127001719 4Fe-4S binding domain; Region: Fer4; pfam00037 645127001720 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 645127001721 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645127001722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645127001723 homodimer interface [polypeptide binding]; other site 645127001724 catalytic residue [active] 645127001725 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 645127001726 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 645127001727 putative trimer interface [polypeptide binding]; other site 645127001728 putative CoA binding site [chemical binding]; other site 645127001729 S-methylmethionine transporter; Provisional; Region: PRK11387 645127001730 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 645127001731 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 645127001732 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 645127001733 metal binding site [ion binding]; metal-binding site 645127001734 putative dimer interface [polypeptide binding]; other site 645127001735 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 645127001736 dihydropteroate synthase; Region: DHPS; TIGR01496 645127001737 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 645127001738 substrate binding pocket [chemical binding]; other site 645127001739 dimer interface [polypeptide binding]; other site 645127001740 inhibitor binding site; inhibition site 645127001741 DivIVA domain; Region: DivI1A_domain; TIGR03544 645127001742 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 645127001743 Methyltransferase domain; Region: Methyltransf_31; pfam13847 645127001744 Methyltransferase domain; Region: Methyltransf_11; pfam08241 645127001745 S-adenosylmethionine binding site [chemical binding]; other site 645127001746 Transcriptional regulators [Transcription]; Region: MarR; COG1846 645127001747 MarR family; Region: MarR_2; pfam12802 645127001748 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 645127001749 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 645127001750 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 645127001751 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 645127001752 ligand binding site; other site 645127001753 oligomer interface; other site 645127001754 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 645127001755 dimer interface [polypeptide binding]; other site 645127001756 N-terminal domain interface [polypeptide binding]; other site 645127001757 sulfate 1 binding site; other site 645127001758 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 645127001759 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 645127001760 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 645127001761 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 645127001762 DNA binding residues [nucleotide binding] 645127001763 Putative zinc-finger; Region: zf-HC2; pfam13490 645127001764 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 645127001765 Domain of unknown function DUF59; Region: DUF59; pfam01883 645127001766 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 645127001767 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 645127001768 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 645127001769 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 645127001770 MgtE intracellular N domain; Region: MgtE_N; smart00924 645127001771 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 645127001772 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 645127001773 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 645127001774 oligomer interface [polypeptide binding]; other site 645127001775 metal binding site [ion binding]; metal-binding site 645127001776 metal binding site [ion binding]; metal-binding site 645127001777 putative Cl binding site [ion binding]; other site 645127001778 basic sphincter; other site 645127001779 hydrophobic gate; other site 645127001780 periplasmic entrance; other site 645127001781 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 645127001782 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 645127001783 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 645127001784 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 645127001785 TPP-binding site [chemical binding]; other site 645127001786 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 645127001787 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 645127001788 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 645127001789 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645127001790 Walker A/P-loop; other site 645127001791 ATP binding site [chemical binding]; other site 645127001792 Q-loop/lid; other site 645127001793 ABC transporter signature motif; other site 645127001794 Walker B; other site 645127001795 D-loop; other site 645127001796 H-loop/switch region; other site 645127001797 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 645127001798 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 645127001799 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645127001800 Walker A/P-loop; other site 645127001801 ATP binding site [chemical binding]; other site 645127001802 Q-loop/lid; other site 645127001803 ABC transporter signature motif; other site 645127001804 Walker B; other site 645127001805 D-loop; other site 645127001806 H-loop/switch region; other site 645127001807 glycyl-tRNA synthetase; Provisional; Region: PRK04173 645127001808 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 645127001809 motif 1; other site 645127001810 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 645127001811 active site 645127001812 motif 2; other site 645127001813 motif 3; other site 645127001814 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 645127001815 anticodon binding site; other site 645127001816 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 645127001817 Uncharacterized conserved protein [Function unknown]; Region: COG1434 645127001818 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 645127001819 putative active site [active] 645127001820 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 645127001821 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 645127001822 Zn2+ binding site [ion binding]; other site 645127001823 Mg2+ binding site [ion binding]; other site 645127001824 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 645127001825 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 645127001826 active site 645127001827 DNA primase; Validated; Region: dnaG; PRK05667 645127001828 CHC2 zinc finger; Region: zf-CHC2; pfam01807 645127001829 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 645127001830 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 645127001831 active site 645127001832 metal binding site [ion binding]; metal-binding site 645127001833 interdomain interaction site; other site 645127001834 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 645127001835 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 645127001836 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 645127001837 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 645127001838 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 645127001839 active site 645127001840 catalytic tetrad [active] 645127001841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645127001842 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645127001843 putative substrate translocation pore; other site 645127001844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645127001845 putative substrate translocation pore; other site 645127001846 Predicted membrane protein [Function unknown]; Region: COG2860 645127001847 UPF0126 domain; Region: UPF0126; pfam03458 645127001848 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 645127001849 Beta-lactamase; Region: Beta-lactamase; pfam00144 645127001850 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 645127001851 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 645127001852 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 645127001853 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 645127001854 dimer interface [polypeptide binding]; other site 645127001855 TPP-binding site [chemical binding]; other site 645127001856 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 645127001857 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 645127001858 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 645127001859 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 645127001860 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 645127001861 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 645127001862 Low molecular weight phosphatase family; Region: LMWPc; cd00115 645127001863 active site 645127001864 hypothetical protein; Provisional; Region: PRK07908 645127001865 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645127001866 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645127001867 homodimer interface [polypeptide binding]; other site 645127001868 catalytic residue [active] 645127001869 Uncharacterized conserved protein [Function unknown]; Region: COG0327 645127001870 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 645127001871 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 645127001872 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 645127001873 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 645127001874 Putative zinc ribbon domain; Region: DUF164; pfam02591 645127001875 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 645127001876 catalytic core [active] 645127001877 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 645127001878 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 645127001879 putative active site; other site 645127001880 putative metal binding residues [ion binding]; other site 645127001881 signature motif; other site 645127001882 putative triphosphate binding site [ion binding]; other site 645127001883 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 645127001884 oligomerization interface [polypeptide binding]; other site 645127001885 active site 645127001886 metal binding site [ion binding]; metal-binding site 645127001887 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 645127001888 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 645127001889 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 645127001890 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 645127001891 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 645127001892 metal binding triad; other site 645127001893 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 645127001894 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 645127001895 metal binding triad; other site 645127001896 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 645127001897 Predicted membrane protein [Function unknown]; Region: COG2246 645127001898 GtrA-like protein; Region: GtrA; pfam04138 645127001899 Transcriptional regulators [Transcription]; Region: MarR; COG1846 645127001900 MarR family; Region: MarR_2; pfam12802 645127001901 pyruvate dehydrogenase; Provisional; Region: PRK06546 645127001902 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 645127001903 PYR/PP interface [polypeptide binding]; other site 645127001904 dimer interface [polypeptide binding]; other site 645127001905 tetramer interface [polypeptide binding]; other site 645127001906 TPP binding site [chemical binding]; other site 645127001907 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 645127001908 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 645127001909 TPP-binding site [chemical binding]; other site 645127001910 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 645127001911 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 645127001912 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645127001913 catalytic residue [active] 645127001914 glutamine synthetase, type I; Region: GlnA; TIGR00653 645127001915 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 645127001916 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 645127001917 RDD family; Region: RDD; pfam06271 645127001918 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 645127001919 lipoyl synthase; Provisional; Region: PRK05481 645127001920 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645127001921 FeS/SAM binding site; other site 645127001922 lipoate-protein ligase B; Provisional; Region: PRK14345 645127001923 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 645127001924 E3 interaction surface; other site 645127001925 lipoyl attachment site [posttranslational modification]; other site 645127001926 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 645127001927 E3 interaction surface; other site 645127001928 lipoyl attachment site [posttranslational modification]; other site 645127001929 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 645127001930 E3 interaction surface; other site 645127001931 lipoyl attachment site [posttranslational modification]; other site 645127001932 e3 binding domain; Region: E3_binding; pfam02817 645127001933 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 645127001934 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 645127001935 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 645127001936 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 645127001937 homodimer interface [polypeptide binding]; other site 645127001938 substrate-cofactor binding pocket; other site 645127001939 catalytic residue [active] 645127001940 cobalamin synthase; Reviewed; Region: cobS; PRK00235 645127001941 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 645127001942 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 645127001943 putative dimer interface [polypeptide binding]; other site 645127001944 active site pocket [active] 645127001945 putative cataytic base [active] 645127001946 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 645127001947 homotrimer interface [polypeptide binding]; other site 645127001948 Walker A motif; other site 645127001949 GTP binding site [chemical binding]; other site 645127001950 Walker B motif; other site 645127001951 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 645127001952 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 645127001953 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 645127001954 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 645127001955 active site 645127001956 dimer interface [polypeptide binding]; other site 645127001957 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 645127001958 Ligand Binding Site [chemical binding]; other site 645127001959 Molecular Tunnel; other site 645127001960 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 645127001961 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 645127001962 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 645127001963 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 645127001964 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 645127001965 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 645127001966 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 645127001967 Subunit I/III interface [polypeptide binding]; other site 645127001968 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 645127001969 Cytochrome c; Region: Cytochrom_C; pfam00034 645127001970 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 645127001971 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 645127001972 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 645127001973 iron-sulfur cluster [ion binding]; other site 645127001974 [2Fe-2S] cluster binding site [ion binding]; other site 645127001975 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 645127001976 heme bH binding site [chemical binding]; other site 645127001977 intrachain domain interface; other site 645127001978 heme bL binding site [chemical binding]; other site 645127001979 interchain domain interface [polypeptide binding]; other site 645127001980 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 645127001981 Qo binding site; other site 645127001982 hypothetical protein; Validated; Region: PRK07883 645127001983 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 645127001984 active site 645127001985 catalytic site [active] 645127001986 substrate binding site [chemical binding]; other site 645127001987 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 645127001988 GIY-YIG motif/motif A; other site 645127001989 active site 645127001990 catalytic site [active] 645127001991 putative DNA binding site [nucleotide binding]; other site 645127001992 metal binding site [ion binding]; metal-binding site 645127001993 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 645127001994 NlpC/P60 family; Region: NLPC_P60; cl17555 645127001995 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 645127001996 NlpC/P60 family; Region: NLPC_P60; pfam00877 645127001997 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 645127001998 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 645127001999 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 645127002000 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 645127002001 nucleotide binding site [chemical binding]; other site 645127002002 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 645127002003 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 645127002004 putative acyl-acceptor binding pocket; other site 645127002005 Predicted membrane protein [Function unknown]; Region: COG4763 645127002006 Acyltransferase family; Region: Acyl_transf_3; pfam01757 645127002007 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 645127002008 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 645127002009 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 645127002010 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 645127002011 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 645127002012 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 645127002013 active site 645127002014 ATP binding site [chemical binding]; other site 645127002015 substrate binding site [chemical binding]; other site 645127002016 activation loop (A-loop); other site 645127002017 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 645127002018 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 645127002019 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 645127002020 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 645127002021 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 645127002022 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 645127002023 phytoene desaturase; Region: crtI_fam; TIGR02734 645127002024 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 645127002025 hydroxyglutarate oxidase; Provisional; Region: PRK11728 645127002026 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 645127002027 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 645127002028 substrate binding pocket [chemical binding]; other site 645127002029 chain length determination region; other site 645127002030 substrate-Mg2+ binding site; other site 645127002031 catalytic residues [active] 645127002032 aspartate-rich region 1; other site 645127002033 active site lid residues [active] 645127002034 aspartate-rich region 2; other site 645127002035 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 645127002036 FAD binding site [chemical binding]; other site 645127002037 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 645127002038 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 645127002039 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 645127002040 cell division protein MraZ; Reviewed; Region: PRK00326 645127002041 MraZ protein; Region: MraZ; pfam02381 645127002042 MraZ protein; Region: MraZ; pfam02381 645127002043 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 645127002044 MraW methylase family; Region: Methyltransf_5; cl17771 645127002045 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 645127002046 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 645127002047 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 645127002048 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 645127002049 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 645127002050 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 645127002051 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 645127002052 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 645127002053 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 645127002054 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 645127002055 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 645127002056 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 645127002057 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 645127002058 Mg++ binding site [ion binding]; other site 645127002059 putative catalytic motif [active] 645127002060 putative substrate binding site [chemical binding]; other site 645127002061 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141 645127002062 XdhC Rossmann domain; Region: XdhC_C; pfam13478 645127002063 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 645127002064 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 645127002065 cell division protein FtsW; Region: ftsW; TIGR02614 645127002066 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 645127002067 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 645127002068 active site 645127002069 homodimer interface [polypeptide binding]; other site 645127002070 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 645127002071 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 645127002072 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 645127002073 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 645127002074 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 645127002075 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 645127002076 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 645127002077 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 645127002078 nucleotide binding site [chemical binding]; other site 645127002079 SulA interaction site; other site 645127002080 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 645127002081 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 645127002082 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 645127002083 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 645127002084 catalytic residue [active] 645127002085 Protein of unknown function (DUF552); Region: DUF552; pfam04472 645127002086 DivIVA domain; Region: DivI1A_domain; TIGR03544 645127002087 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 645127002088 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 645127002089 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 645127002090 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 645127002091 HIGH motif; other site 645127002092 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 645127002093 active site 645127002094 KMSKS motif; other site 645127002095 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 645127002096 tRNA binding surface [nucleotide binding]; other site 645127002097 anticodon binding site; other site 645127002098 DNA polymerase IV; Provisional; Region: PRK03348 645127002099 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 645127002100 active site 645127002101 DNA binding site [nucleotide binding] 645127002102 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 645127002103 active site 645127002104 homotetramer interface [polypeptide binding]; other site 645127002105 homodimer interface [polypeptide binding]; other site 645127002106 lipoprotein signal peptidase; Provisional; Region: PRK14787 645127002107 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 645127002108 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 645127002109 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 645127002110 active site 645127002111 Predicted permeases [General function prediction only]; Region: RarD; COG2962 645127002112 EamA-like transporter family; Region: EamA; pfam00892 645127002113 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 645127002114 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 645127002115 catalytic residue [active] 645127002116 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 645127002117 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 645127002118 active site 645127002119 PHP Thumb interface [polypeptide binding]; other site 645127002120 metal binding site [ion binding]; metal-binding site 645127002121 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 645127002122 generic binding surface II; other site 645127002123 generic binding surface I; other site 645127002124 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 645127002125 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 645127002126 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 645127002127 catalytic site [active] 645127002128 active site 645127002129 Uncharacterized conserved protein [Function unknown]; Region: COG1739 645127002130 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 645127002131 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 645127002132 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 645127002133 intersubunit interface [polypeptide binding]; other site 645127002134 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) [Translation, ribosomal structure and biogenesis]; Region: COG1188 645127002135 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 645127002136 synthetase active site [active] 645127002137 NTP binding site [chemical binding]; other site 645127002138 metal binding site [ion binding]; metal-binding site 645127002139 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 645127002140 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 645127002141 active site 645127002142 catalytic site [active] 645127002143 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 645127002144 catalytic residue [active] 645127002145 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 645127002146 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 645127002147 active site 645127002148 catalytic site [active] 645127002149 substrate binding site [chemical binding]; other site 645127002150 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 645127002151 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 645127002152 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 645127002153 active site 645127002154 catalytic site [active] 645127002155 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645127002156 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645127002157 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 645127002158 biotin synthase; Validated; Region: PRK06256 645127002159 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645127002160 FeS/SAM binding site; other site 645127002161 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 645127002162 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 645127002163 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 645127002164 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 645127002165 NAD binding site [chemical binding]; other site 645127002166 dimerization interface [polypeptide binding]; other site 645127002167 product binding site; other site 645127002168 substrate binding site [chemical binding]; other site 645127002169 zinc binding site [ion binding]; other site 645127002170 catalytic residues [active] 645127002171 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 645127002172 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645127002173 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645127002174 homodimer interface [polypeptide binding]; other site 645127002175 catalytic residue [active] 645127002176 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 645127002177 putative active site pocket [active] 645127002178 4-fold oligomerization interface [polypeptide binding]; other site 645127002179 metal binding residues [ion binding]; metal-binding site 645127002180 3-fold/trimer interface [polypeptide binding]; other site 645127002181 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 645127002182 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 645127002183 putative active site [active] 645127002184 oxyanion strand; other site 645127002185 catalytic triad [active] 645127002186 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 645127002187 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 645127002188 catalytic residues [active] 645127002189 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 645127002190 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 645127002191 active site 645127002192 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 645127002193 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 645127002194 substrate binding site [chemical binding]; other site 645127002195 glutamase interaction surface [polypeptide binding]; other site 645127002196 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 645127002197 anthranilate synthase component I; Provisional; Region: PRK13571 645127002198 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 645127002199 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 645127002200 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 645127002201 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 645127002202 active site 645127002203 ribulose/triose binding site [chemical binding]; other site 645127002204 phosphate binding site [ion binding]; other site 645127002205 substrate (anthranilate) binding pocket [chemical binding]; other site 645127002206 product (indole) binding pocket [chemical binding]; other site 645127002207 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 645127002208 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 645127002209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645127002210 catalytic residue [active] 645127002211 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 645127002212 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 645127002213 substrate binding site [chemical binding]; other site 645127002214 active site 645127002215 catalytic residues [active] 645127002216 heterodimer interface [polypeptide binding]; other site 645127002217 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 645127002218 pyruvate kinase; Provisional; Region: PRK06247 645127002219 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 645127002220 domain interfaces; other site 645127002221 active site 645127002222 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 645127002223 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 645127002224 metal binding site [ion binding]; metal-binding site 645127002225 putative dimer interface [polypeptide binding]; other site 645127002226 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 645127002227 UreD urease accessory protein; Region: UreD; pfam01774 645127002228 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 645127002229 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 645127002230 UreF; Region: UreF; pfam01730 645127002231 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 645127002232 alpha-beta subunit interface [polypeptide binding]; other site 645127002233 urease subunit alpha; Reviewed; Region: ureC; PRK13207 645127002234 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 645127002235 subunit interactions [polypeptide binding]; other site 645127002236 active site 645127002237 flap region; other site 645127002238 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 645127002239 alpha-gamma subunit interface [polypeptide binding]; other site 645127002240 beta-gamma subunit interface [polypeptide binding]; other site 645127002241 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 645127002242 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 645127002243 nucleotide binding site/active site [active] 645127002244 HIT family signature motif; other site 645127002245 catalytic residue [active] 645127002246 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 645127002247 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 645127002248 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 645127002249 active site 645127002250 catalytic triad [active] 645127002251 oxyanion hole [active] 645127002252 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 645127002253 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 645127002254 active site residue [active] 645127002255 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 645127002256 active site residue [active] 645127002257 DNA polymerase I; Provisional; Region: PRK05755 645127002258 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 645127002259 active site 645127002260 metal binding site 1 [ion binding]; metal-binding site 645127002261 putative 5' ssDNA interaction site; other site 645127002262 metal binding site 3; metal-binding site 645127002263 metal binding site 2 [ion binding]; metal-binding site 645127002264 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 645127002265 putative DNA binding site [nucleotide binding]; other site 645127002266 putative metal binding site [ion binding]; other site 645127002267 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 645127002268 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 645127002269 active site 645127002270 DNA binding site [nucleotide binding] 645127002271 catalytic site [active] 645127002272 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 645127002273 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 645127002274 RNA binding site [nucleotide binding]; other site 645127002275 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 645127002276 RNA binding site [nucleotide binding]; other site 645127002277 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 645127002278 RNA binding site [nucleotide binding]; other site 645127002279 S1 RNA binding domain; Region: S1; pfam00575 645127002280 RNA binding site [nucleotide binding]; other site 645127002281 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 645127002282 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 645127002283 active site turn [active] 645127002284 phosphorylation site [posttranslational modification] 645127002285 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 645127002286 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 645127002287 HPr interaction site; other site 645127002288 glycerol kinase (GK) interaction site [polypeptide binding]; other site 645127002289 active site 645127002290 phosphorylation site [posttranslational modification] 645127002291 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 645127002292 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 645127002293 active site 2 [active] 645127002294 active site 1 [active] 645127002295 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 645127002296 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 645127002297 NAD(P) binding site [chemical binding]; other site 645127002298 active site 645127002299 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 645127002300 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 645127002301 dimer interface [polypeptide binding]; other site 645127002302 active site 645127002303 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 645127002304 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 645127002305 CoA-binding site [chemical binding]; other site 645127002306 ATP-binding [chemical binding]; other site 645127002307 excinuclease ABC subunit B; Provisional; Region: PRK05298 645127002308 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 645127002309 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645127002310 nucleotide binding region [chemical binding]; other site 645127002311 ATP-binding site [chemical binding]; other site 645127002312 Ultra-violet resistance protein B; Region: UvrB; pfam12344 645127002313 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 645127002314 Ligand Binding Site [chemical binding]; other site 645127002315 Putative esterase; Region: Esterase; pfam00756 645127002316 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 645127002317 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 645127002318 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 645127002319 Family description; Region: UvrD_C_2; pfam13538 645127002320 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 645127002321 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 645127002322 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 645127002323 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 645127002324 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 645127002325 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 645127002326 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 645127002327 dimer interface [polypeptide binding]; other site 645127002328 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645127002329 catalytic residue [active] 645127002330 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 645127002331 cystathionine gamma-synthase; Provisional; Region: PRK07811 645127002332 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 645127002333 homodimer interface [polypeptide binding]; other site 645127002334 substrate-cofactor binding pocket; other site 645127002335 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645127002336 catalytic residue [active] 645127002337 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 645127002338 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 645127002339 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 645127002340 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 645127002341 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 645127002342 23S rRNA binding site [nucleotide binding]; other site 645127002343 L21 binding site [polypeptide binding]; other site 645127002344 L13 binding site [polypeptide binding]; other site 645127002345 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 645127002346 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 645127002347 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 645127002348 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 645127002349 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 645127002350 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 645127002351 dimer interface [polypeptide binding]; other site 645127002352 motif 1; other site 645127002353 active site 645127002354 motif 2; other site 645127002355 motif 3; other site 645127002356 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 645127002357 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 645127002358 putative tRNA-binding site [nucleotide binding]; other site 645127002359 B3/4 domain; Region: B3_4; pfam03483 645127002360 tRNA synthetase B5 domain; Region: B5; smart00874 645127002361 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 645127002362 dimer interface [polypeptide binding]; other site 645127002363 motif 1; other site 645127002364 motif 3; other site 645127002365 motif 2; other site 645127002366 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 645127002367 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 645127002368 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 645127002369 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 645127002370 heterotetramer interface [polypeptide binding]; other site 645127002371 active site pocket [active] 645127002372 cleavage site 645127002373 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 645127002374 feedback inhibition sensing region; other site 645127002375 homohexameric interface [polypeptide binding]; other site 645127002376 nucleotide binding site [chemical binding]; other site 645127002377 N-acetyl-L-glutamate binding site [chemical binding]; other site 645127002378 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 645127002379 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 645127002380 inhibitor-cofactor binding pocket; inhibition site 645127002381 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645127002382 catalytic residue [active] 645127002383 ornithine carbamoyltransferase; Provisional; Region: PRK00779 645127002384 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 645127002385 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 645127002386 arginine repressor; Provisional; Region: PRK03341 645127002387 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 645127002388 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 645127002389 argininosuccinate synthase; Provisional; Region: PRK13820 645127002390 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 645127002391 ANP binding site [chemical binding]; other site 645127002392 Substrate Binding Site II [chemical binding]; other site 645127002393 Substrate Binding Site I [chemical binding]; other site 645127002394 argininosuccinate lyase; Provisional; Region: PRK00855 645127002395 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 645127002396 active sites [active] 645127002397 tetramer interface [polypeptide binding]; other site 645127002398 Uncharacterized conserved protein [Function unknown]; Region: COG2835 645127002399 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 645127002400 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 645127002401 active site 645127002402 HIGH motif; other site 645127002403 dimer interface [polypeptide binding]; other site 645127002404 KMSKS motif; other site 645127002405 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 645127002406 RNA binding surface [nucleotide binding]; other site 645127002407 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 645127002408 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645127002409 active site 645127002410 motif I; other site 645127002411 motif II; other site 645127002412 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645127002413 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 645127002414 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 645127002415 RNA binding surface [nucleotide binding]; other site 645127002416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645127002417 S-adenosylmethionine binding site [chemical binding]; other site 645127002418 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 645127002419 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 645127002420 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 645127002421 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645127002422 Walker A/P-loop; other site 645127002423 ATP binding site [chemical binding]; other site 645127002424 Q-loop/lid; other site 645127002425 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 645127002426 ABC transporter signature motif; other site 645127002427 Walker B; other site 645127002428 D-loop; other site 645127002429 H-loop/switch region; other site 645127002430 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 645127002431 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 645127002432 CTP synthetase; Validated; Region: pyrG; PRK05380 645127002433 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 645127002434 Catalytic site [active] 645127002435 active site 645127002436 UTP binding site [chemical binding]; other site 645127002437 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 645127002438 active site 645127002439 putative oxyanion hole; other site 645127002440 catalytic triad [active] 645127002441 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 645127002442 dimer interface [polypeptide binding]; other site 645127002443 ADP-ribose binding site [chemical binding]; other site 645127002444 active site 645127002445 nudix motif; other site 645127002446 metal binding site [ion binding]; metal-binding site 645127002447 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 645127002448 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 645127002449 active site 645127002450 Int/Topo IB signature motif; other site 645127002451 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 645127002452 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 645127002453 P-loop; other site 645127002454 Magnesium ion binding site [ion binding]; other site 645127002455 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 645127002456 Magnesium ion binding site [ion binding]; other site 645127002457 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 645127002458 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 645127002459 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05630 645127002460 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 645127002461 inhibitor-cofactor binding pocket; inhibition site 645127002462 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645127002463 catalytic residue [active] 645127002464 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 645127002465 AAA domain; Region: AAA_26; pfam13500 645127002466 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 645127002467 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 645127002468 RNA binding surface [nucleotide binding]; other site 645127002469 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 645127002470 active site 645127002471 cytidylate kinase; Provisional; Region: cmk; PRK00023 645127002472 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 645127002473 CMP-binding site; other site 645127002474 The sites determining sugar specificity; other site 645127002475 GTP-binding protein Der; Reviewed; Region: PRK03003 645127002476 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 645127002477 G1 box; other site 645127002478 GTP/Mg2+ binding site [chemical binding]; other site 645127002479 Switch I region; other site 645127002480 G2 box; other site 645127002481 Switch II region; other site 645127002482 G3 box; other site 645127002483 G4 box; other site 645127002484 G5 box; other site 645127002485 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 645127002486 G1 box; other site 645127002487 GTP/Mg2+ binding site [chemical binding]; other site 645127002488 Switch I region; other site 645127002489 G2 box; other site 645127002490 G3 box; other site 645127002491 Switch II region; other site 645127002492 G4 box; other site 645127002493 G5 box; other site 645127002494 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 645127002495 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 645127002496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645127002497 S-adenosylmethionine binding site [chemical binding]; other site 645127002498 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 645127002499 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 645127002500 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 645127002501 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 645127002502 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 645127002503 nucleotide binding region [chemical binding]; other site 645127002504 ATP-binding site [chemical binding]; other site 645127002505 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 645127002506 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 645127002507 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 645127002508 phosphopeptide binding site; other site 645127002509 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 645127002510 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 645127002511 DNA binding residues [nucleotide binding] 645127002512 Bifunctional nuclease; Region: DNase-RNase; cl00553 645127002513 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422 645127002514 DNA binding residues [nucleotide binding] 645127002515 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 645127002516 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 645127002517 metal ion-dependent adhesion site (MIDAS); other site 645127002518 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 645127002519 Domain of unknown function DUF21; Region: DUF21; pfam01595 645127002520 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 645127002521 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 645127002522 Domain of unknown function DUF21; Region: DUF21; pfam01595 645127002523 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 645127002524 Transporter associated domain; Region: CorC_HlyC; smart01091 645127002525 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 645127002526 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 645127002527 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 645127002528 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 645127002529 CoenzymeA binding site [chemical binding]; other site 645127002530 subunit interaction site [polypeptide binding]; other site 645127002531 PHB binding site; other site 645127002532 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 645127002533 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 645127002534 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 645127002535 Methyltransferase domain; Region: Methyltransf_18; pfam12847 645127002536 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 645127002537 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 645127002538 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 645127002539 active site 645127002540 metabolite-proton symporter; Region: 2A0106; TIGR00883 645127002541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645127002542 putative substrate translocation pore; other site 645127002543 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 645127002544 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 645127002545 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 645127002546 TrkA-N domain; Region: TrkA_N; pfam02254 645127002547 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 645127002548 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 645127002549 Sulfate transporter family; Region: Sulfate_transp; pfam00916 645127002550 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 645127002551 Cation efflux family; Region: Cation_efflux; cl00316 645127002552 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 645127002553 membrane-bound complex binding site; other site 645127002554 hinge residues; other site 645127002555 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 645127002556 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 645127002557 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 645127002558 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645127002559 Walker A/P-loop; other site 645127002560 ATP binding site [chemical binding]; other site 645127002561 Q-loop/lid; other site 645127002562 ABC transporter signature motif; other site 645127002563 Walker B; other site 645127002564 D-loop; other site 645127002565 H-loop/switch region; other site 645127002566 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 645127002567 YceI-like domain; Region: YceI; pfam04264 645127002568 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 645127002569 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 645127002570 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 645127002571 Ligand binding site; other site 645127002572 Putative Catalytic site; other site 645127002573 DXD motif; other site 645127002574 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 645127002575 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 645127002576 putative active site [active] 645127002577 catalytic triad [active] 645127002578 putative dimer interface [polypeptide binding]; other site 645127002579 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 645127002580 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 645127002581 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 645127002582 precorrin-3B synthase; Region: CobG; TIGR02435 645127002583 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 645127002584 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 645127002585 Precorrin-8X methylmutase; Region: CbiC; pfam02570 645127002586 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 645127002587 active site 645127002588 SAM binding site [chemical binding]; other site 645127002589 homodimer interface [polypeptide binding]; other site 645127002590 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 645127002591 active site 645127002592 SAM binding site [chemical binding]; other site 645127002593 homodimer interface [polypeptide binding]; other site 645127002594 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 645127002595 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 645127002596 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 645127002597 active site 645127002598 SAM binding site [chemical binding]; other site 645127002599 homodimer interface [polypeptide binding]; other site 645127002600 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 645127002601 active site 645127002602 putative homodimer interface [polypeptide binding]; other site 645127002603 SAM binding site [chemical binding]; other site 645127002604 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 645127002605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645127002606 S-adenosylmethionine binding site [chemical binding]; other site 645127002607 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 645127002608 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 645127002609 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 645127002610 active site 645127002611 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 645127002612 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 645127002613 ATP binding site [chemical binding]; other site 645127002614 putative Mg++ binding site [ion binding]; other site 645127002615 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645127002616 nucleotide binding region [chemical binding]; other site 645127002617 ATP-binding site [chemical binding]; other site 645127002618 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 645127002619 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 645127002620 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 645127002621 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 645127002622 Predicted transcriptional regulator [Transcription]; Region: COG2378 645127002623 WYL domain; Region: WYL; pfam13280 645127002624 Predicted transcriptional regulator [Transcription]; Region: COG2378 645127002625 WYL domain; Region: WYL; pfam13280 645127002626 Pup-ligase protein; Region: Pup_ligase; cl15463 645127002627 Pup-like protein; Region: Pup; cl05289 645127002628 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 645127002629 proteasome ATPase; Region: pup_AAA; TIGR03689 645127002630 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645127002631 Walker A motif; other site 645127002632 ATP binding site [chemical binding]; other site 645127002633 Walker B motif; other site 645127002634 arginine finger; other site 645127002635 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 645127002636 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 645127002637 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 645127002638 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 645127002639 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 645127002640 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 645127002641 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 645127002642 homodimer interface [polypeptide binding]; other site 645127002643 putative metal binding site [ion binding]; other site 645127002644 phosphoglycolate phosphatase; Provisional; Region: PRK13222 645127002645 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645127002646 motif II; other site 645127002647 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 645127002648 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 645127002649 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 645127002650 substrate binding pocket [chemical binding]; other site 645127002651 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 645127002652 B12 binding site [chemical binding]; other site 645127002653 cobalt ligand [ion binding]; other site 645127002654 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 645127002655 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 645127002656 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 645127002657 active site 645127002658 HIGH motif; other site 645127002659 nucleotide binding site [chemical binding]; other site 645127002660 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 645127002661 active site 645127002662 KMSKS motif; other site 645127002663 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 645127002664 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 645127002665 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 645127002666 quinone interaction residues [chemical binding]; other site 645127002667 active site 645127002668 catalytic residues [active] 645127002669 FMN binding site [chemical binding]; other site 645127002670 substrate binding site [chemical binding]; other site 645127002671 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 645127002672 substrate binding site [chemical binding]; other site 645127002673 membrane ATPase/protein kinase; Provisional; Region: PRK09435 645127002674 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 645127002675 GTP/Mg2+ binding site [chemical binding]; other site 645127002676 G5 box; other site 645127002677 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 645127002678 Walker A; other site 645127002679 G1 box; other site 645127002680 Switch I region; other site 645127002681 G2 box; other site 645127002682 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 645127002683 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 645127002684 active site 645127002685 substrate binding site [chemical binding]; other site 645127002686 coenzyme B12 binding site [chemical binding]; other site 645127002687 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 645127002688 B12 binding site [chemical binding]; other site 645127002689 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 645127002690 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 645127002691 heterodimer interface [polypeptide binding]; other site 645127002692 substrate interaction site [chemical binding]; other site 645127002693 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 645127002694 Uncharacterized conserved protein [Function unknown]; Region: COG0398 645127002695 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 645127002696 HflC protein; Region: hflC; TIGR01932 645127002697 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 645127002698 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 645127002699 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 645127002700 ferrochelatase; Reviewed; Region: hemH; PRK00035 645127002701 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 645127002702 C-terminal domain interface [polypeptide binding]; other site 645127002703 active site 645127002704 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 645127002705 active site 645127002706 N-terminal domain interface [polypeptide binding]; other site 645127002707 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 645127002708 NlpC/P60 family; Region: NLPC_P60; pfam00877 645127002709 aconitate hydratase; Validated; Region: PRK09277 645127002710 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 645127002711 substrate binding site [chemical binding]; other site 645127002712 ligand binding site [chemical binding]; other site 645127002713 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 645127002714 substrate binding site [chemical binding]; other site 645127002715 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645127002716 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645127002717 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 645127002718 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 645127002719 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 645127002720 catalytic triad [active] 645127002721 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 645127002722 NADH(P)-binding; Region: NAD_binding_10; pfam13460 645127002723 NAD(P) binding site [chemical binding]; other site 645127002724 active site 645127002725 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 645127002726 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645127002727 Walker A/P-loop; other site 645127002728 ATP binding site [chemical binding]; other site 645127002729 Q-loop/lid; other site 645127002730 ABC transporter signature motif; other site 645127002731 Walker B; other site 645127002732 D-loop; other site 645127002733 H-loop/switch region; other site 645127002734 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 645127002735 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 645127002736 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 645127002737 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 645127002738 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 645127002739 trimerization site [polypeptide binding]; other site 645127002740 active site 645127002741 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 645127002742 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 645127002743 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 645127002744 catalytic residue [active] 645127002745 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 645127002746 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 645127002747 Walker A/P-loop; other site 645127002748 ATP binding site [chemical binding]; other site 645127002749 Q-loop/lid; other site 645127002750 ABC transporter signature motif; other site 645127002751 Walker B; other site 645127002752 D-loop; other site 645127002753 H-loop/switch region; other site 645127002754 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 645127002755 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 645127002756 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 645127002757 FeS assembly protein SufB; Region: sufB; TIGR01980 645127002758 Predicted transcriptional regulator [Transcription]; Region: COG2345 645127002759 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 645127002760 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 645127002761 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 645127002762 Walker A/P-loop; other site 645127002763 ATP binding site [chemical binding]; other site 645127002764 Q-loop/lid; other site 645127002765 ABC transporter signature motif; other site 645127002766 Walker B; other site 645127002767 D-loop; other site 645127002768 H-loop/switch region; other site 645127002769 ABC-2 type transporter; Region: ABC2_membrane; cl17235 645127002770 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 645127002771 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 645127002772 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 645127002773 UbiA prenyltransferase family; Region: UbiA; pfam01040 645127002774 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 645127002775 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 645127002776 TPP-binding site [chemical binding]; other site 645127002777 dimer interface [polypeptide binding]; other site 645127002778 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 645127002779 PYR/PP interface [polypeptide binding]; other site 645127002780 dimer interface [polypeptide binding]; other site 645127002781 TPP binding site [chemical binding]; other site 645127002782 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 645127002783 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 645127002784 putative active site [active] 645127002785 transaldolase; Provisional; Region: PRK03903 645127002786 catalytic residue [active] 645127002787 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 645127002788 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 645127002789 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 645127002790 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 645127002791 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 645127002792 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 645127002793 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 645127002794 putative active site [active] 645127002795 Preprotein translocase SecG subunit; Region: SecG; cl09123 645127002796 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 645127002797 catalytic site [active] 645127002798 active site 645127002799 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 645127002800 active site 645127002801 triosephosphate isomerase; Provisional; Region: PRK14567 645127002802 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 645127002803 substrate binding site [chemical binding]; other site 645127002804 dimer interface [polypeptide binding]; other site 645127002805 catalytic triad [active] 645127002806 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 645127002807 Phosphoglycerate kinase; Region: PGK; pfam00162 645127002808 substrate binding site [chemical binding]; other site 645127002809 hinge regions; other site 645127002810 ADP binding site [chemical binding]; other site 645127002811 catalytic site [active] 645127002812 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 645127002813 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 645127002814 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 645127002815 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 645127002816 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 645127002817 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 645127002818 phosphate binding site [ion binding]; other site 645127002819 putative substrate binding pocket [chemical binding]; other site 645127002820 dimer interface [polypeptide binding]; other site 645127002821 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 645127002822 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 645127002823 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 645127002824 GIY-YIG motif/motif A; other site 645127002825 active site 645127002826 catalytic site [active] 645127002827 putative DNA binding site [nucleotide binding]; other site 645127002828 metal binding site [ion binding]; metal-binding site 645127002829 UvrB/uvrC motif; Region: UVR; pfam02151 645127002830 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 645127002831 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 645127002832 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 645127002833 homopentamer interface [polypeptide binding]; other site 645127002834 active site 645127002835 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 645127002836 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 645127002837 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 645127002838 dimerization interface [polypeptide binding]; other site 645127002839 active site 645127002840 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 645127002841 Lumazine binding domain; Region: Lum_binding; pfam00677 645127002842 Lumazine binding domain; Region: Lum_binding; pfam00677 645127002843 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 645127002844 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 645127002845 catalytic motif [active] 645127002846 Zn binding site [ion binding]; other site 645127002847 RibD C-terminal domain; Region: RibD_C; cl17279 645127002848 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 645127002849 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 645127002850 substrate binding site [chemical binding]; other site 645127002851 hexamer interface [polypeptide binding]; other site 645127002852 metal binding site [ion binding]; metal-binding site 645127002853 16S rRNA methyltransferase B; Provisional; Region: PRK14902 645127002854 NusB family; Region: NusB; pfam01029 645127002855 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645127002856 S-adenosylmethionine binding site [chemical binding]; other site 645127002857 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 645127002858 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 645127002859 putative active site [active] 645127002860 substrate binding site [chemical binding]; other site 645127002861 putative cosubstrate binding site; other site 645127002862 catalytic site [active] 645127002863 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 645127002864 substrate binding site [chemical binding]; other site 645127002865 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 645127002866 active site 645127002867 catalytic residues [active] 645127002868 metal binding site [ion binding]; metal-binding site 645127002869 primosome assembly protein PriA; Provisional; Region: PRK14873 645127002870 S-adenosylmethionine synthetase; Validated; Region: PRK05250 645127002871 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 645127002872 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 645127002873 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 645127002874 Flavoprotein; Region: Flavoprotein; pfam02441 645127002875 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 645127002876 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 645127002877 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 645127002878 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 645127002879 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 645127002880 catalytic site [active] 645127002881 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 645127002882 active site 645127002883 dimer interface [polypeptide binding]; other site 645127002884 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 645127002885 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 645127002886 ATP-grasp domain; Region: ATP-grasp_4; cl17255 645127002887 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 645127002888 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 645127002889 ATP-grasp domain; Region: ATP-grasp_4; cl17255 645127002890 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 645127002891 IMP binding site; other site 645127002892 dimer interface [polypeptide binding]; other site 645127002893 partial ornithine binding site; other site 645127002894 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 645127002895 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 645127002896 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 645127002897 catalytic site [active] 645127002898 subunit interface [polypeptide binding]; other site 645127002899 dihydroorotase; Validated; Region: pyrC; PRK09357 645127002900 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 645127002901 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 645127002902 active site 645127002903 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 645127002904 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 645127002905 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 645127002906 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 645127002907 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 645127002908 active site 645127002909 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 645127002910 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 645127002911 active site 645127002912 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 645127002913 putative RNA binding site [nucleotide binding]; other site 645127002914 elongation factor P; Validated; Region: PRK00529 645127002915 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 645127002916 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 645127002917 RNA binding site [nucleotide binding]; other site 645127002918 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 645127002919 RNA binding site [nucleotide binding]; other site 645127002920 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 645127002921 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 645127002922 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 645127002923 active site 645127002924 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 645127002925 Dehydroquinase class II; Region: DHquinase_II; pfam01220 645127002926 trimer interface [polypeptide binding]; other site 645127002927 active site 645127002928 dimer interface [polypeptide binding]; other site 645127002929 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 645127002930 active site 645127002931 dimer interface [polypeptide binding]; other site 645127002932 metal binding site [ion binding]; metal-binding site 645127002933 shikimate kinase; Reviewed; Region: aroK; PRK00131 645127002934 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 645127002935 ADP binding site [chemical binding]; other site 645127002936 magnesium binding site [ion binding]; other site 645127002937 putative shikimate binding site; other site 645127002938 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 645127002939 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 645127002940 Tetramer interface [polypeptide binding]; other site 645127002941 active site 645127002942 FMN-binding site [chemical binding]; other site 645127002943 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 645127002944 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 645127002945 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 645127002946 shikimate binding site; other site 645127002947 NAD(P) binding site [chemical binding]; other site 645127002948 YceG-like family; Region: YceG; pfam02618 645127002949 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 645127002950 dimerization interface [polypeptide binding]; other site 645127002951 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 645127002952 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 645127002953 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 645127002954 motif 1; other site 645127002955 active site 645127002956 motif 2; other site 645127002957 motif 3; other site 645127002958 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 645127002959 DHHA1 domain; Region: DHHA1; pfam02272 645127002960 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 645127002961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645127002962 dimer interface [polypeptide binding]; other site 645127002963 conserved gate region; other site 645127002964 putative PBP binding loops; other site 645127002965 ABC-ATPase subunit interface; other site 645127002966 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 645127002967 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 645127002968 Walker A/P-loop; other site 645127002969 ATP binding site [chemical binding]; other site 645127002970 Q-loop/lid; other site 645127002971 ABC transporter signature motif; other site 645127002972 Walker B; other site 645127002973 D-loop; other site 645127002974 H-loop/switch region; other site 645127002975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645127002976 dimer interface [polypeptide binding]; other site 645127002977 conserved gate region; other site 645127002978 ABC-ATPase subunit interface; other site 645127002979 recombination factor protein RarA; Reviewed; Region: PRK13342 645127002980 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645127002981 Walker A motif; other site 645127002982 ATP binding site [chemical binding]; other site 645127002983 Walker B motif; other site 645127002984 arginine finger; other site 645127002985 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 645127002986 Phosphotransferase enzyme family; Region: APH; pfam01636 645127002987 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 645127002988 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 645127002989 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 645127002990 dimer interface [polypeptide binding]; other site 645127002991 anticodon binding site; other site 645127002992 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 645127002993 homodimer interface [polypeptide binding]; other site 645127002994 motif 1; other site 645127002995 active site 645127002996 motif 2; other site 645127002997 GAD domain; Region: GAD; pfam02938 645127002998 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 645127002999 active site 645127003000 motif 3; other site 645127003001 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 645127003002 FAD binding domain; Region: FAD_binding_4; pfam01565 645127003003 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 645127003004 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 645127003005 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 645127003006 dimer interface [polypeptide binding]; other site 645127003007 motif 1; other site 645127003008 active site 645127003009 motif 2; other site 645127003010 motif 3; other site 645127003011 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 645127003012 anticodon binding site; other site 645127003013 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 645127003014 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 645127003015 active site 645127003016 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 645127003017 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 645127003018 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 645127003019 NAD binding site [chemical binding]; other site 645127003020 catalytic Zn binding site [ion binding]; other site 645127003021 substrate binding site [chemical binding]; other site 645127003022 structural Zn binding site [ion binding]; other site 645127003023 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 645127003024 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 645127003025 putative DNA binding site [nucleotide binding]; other site 645127003026 catalytic residue [active] 645127003027 putative H2TH interface [polypeptide binding]; other site 645127003028 putative catalytic residues [active] 645127003029 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 645127003030 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 645127003031 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 645127003032 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 645127003033 Zn2+ binding site [ion binding]; other site 645127003034 Mg2+ binding site [ion binding]; other site 645127003035 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 645127003036 synthetase active site [active] 645127003037 NTP binding site [chemical binding]; other site 645127003038 metal binding site [ion binding]; metal-binding site 645127003039 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 645127003040 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 645127003041 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 645127003042 active site 645127003043 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 645127003044 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 645127003045 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 645127003046 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 645127003047 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 645127003048 Protein export membrane protein; Region: SecD_SecF; pfam02355 645127003049 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 645127003050 Protein export membrane protein; Region: SecD_SecF; cl14618 645127003051 Preprotein translocase subunit; Region: YajC; pfam02699 645127003052 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 645127003053 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645127003054 Walker A motif; other site 645127003055 ATP binding site [chemical binding]; other site 645127003056 Walker B motif; other site 645127003057 arginine finger; other site 645127003058 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 645127003059 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 645127003060 RuvA N terminal domain; Region: RuvA_N; pfam01330 645127003061 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 645127003062 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 645127003063 active site 645127003064 putative DNA-binding cleft [nucleotide binding]; other site 645127003065 dimer interface [polypeptide binding]; other site 645127003066 hypothetical protein; Validated; Region: PRK00110 645127003067 glutamine amidotransferase subunit PdxT; Provisional; Region: PRK13525 645127003068 conserved cys residue [active] 645127003069 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 645127003070 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 645127003071 active site 645127003072 multimer interface [polypeptide binding]; other site 645127003073 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 645127003074 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 645127003075 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 645127003076 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 645127003077 putative acyl-acceptor binding pocket; other site 645127003078 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 645127003079 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 645127003080 nucleotide binding site/active site [active] 645127003081 HIT family signature motif; other site 645127003082 catalytic residue [active] 645127003083 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 645127003084 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 645127003085 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 645127003086 active site 645127003087 dimer interface [polypeptide binding]; other site 645127003088 motif 1; other site 645127003089 motif 2; other site 645127003090 motif 3; other site 645127003091 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 645127003092 anticodon binding site; other site 645127003093 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 645127003094 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 645127003095 Protein of unknown function (DUF461); Region: DUF461; pfam04314 645127003096 CopC domain; Region: CopC; pfam04234 645127003097 RibD C-terminal domain; Region: RibD_C; cl17279 645127003098 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 645127003099 SelR domain; Region: SelR; pfam01641 645127003100 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 645127003101 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 645127003102 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 645127003103 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 645127003104 substrate binding site [chemical binding]; other site 645127003105 active site 645127003106 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 645127003107 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 645127003108 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 645127003109 catalytic site [active] 645127003110 putative active site [active] 645127003111 putative substrate binding site [chemical binding]; other site 645127003112 HRDC domain; Region: HRDC; cl02578 645127003113 TRAM domain; Region: TRAM; cl01282 645127003114 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 645127003115 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 645127003116 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 645127003117 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 645127003118 trimer interface [polypeptide binding]; other site 645127003119 active site 645127003120 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 645127003121 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 645127003122 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 645127003123 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 645127003124 active site 645127003125 dimerization interface [polypeptide binding]; other site 645127003126 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 645127003127 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 645127003128 nucleotide binding site [chemical binding]; other site 645127003129 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 645127003130 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 645127003131 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 645127003132 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 645127003133 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 645127003134 DNA binding residues [nucleotide binding] 645127003135 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 645127003136 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 645127003137 ATP binding site [chemical binding]; other site 645127003138 putative Mg++ binding site [ion binding]; other site 645127003139 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 645127003140 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 645127003141 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 645127003142 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 645127003143 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645127003144 S-adenosylmethionine binding site [chemical binding]; other site 645127003145 D-tyrosyl-tRNA(Tyr) deacylase; Provisional; Region: PRK05273 645127003146 dimerization interface [polypeptide binding]; other site 645127003147 putative tRNAtyr binding site [nucleotide binding]; other site 645127003148 putative active site [active] 645127003149 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 645127003150 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 645127003151 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 645127003152 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 645127003153 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 645127003154 DNA binding residues [nucleotide binding] 645127003155 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 645127003156 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 645127003157 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 645127003158 FeoA domain; Region: FeoA; pfam04023 645127003159 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 645127003160 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 645127003161 intersubunit interface [polypeptide binding]; other site 645127003162 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 645127003163 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 645127003164 dimer interface [polypeptide binding]; other site 645127003165 putative PBP binding regions; other site 645127003166 ABC-ATPase subunit interface; other site 645127003167 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 645127003168 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 645127003169 Walker A/P-loop; other site 645127003170 ATP binding site [chemical binding]; other site 645127003171 Q-loop/lid; other site 645127003172 ABC transporter signature motif; other site 645127003173 Walker B; other site 645127003174 D-loop; other site 645127003175 H-loop/switch region; other site 645127003176 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 645127003177 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 645127003178 NAD binding site [chemical binding]; other site 645127003179 homodimer interface [polypeptide binding]; other site 645127003180 active site 645127003181 substrate binding site [chemical binding]; other site 645127003182 PAC2 family; Region: PAC2; pfam09754 645127003183 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 645127003184 ATP binding site [chemical binding]; other site 645127003185 putative Mg++ binding site [ion binding]; other site 645127003186 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645127003187 nucleotide binding region [chemical binding]; other site 645127003188 ATP-binding site [chemical binding]; other site 645127003189 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 645127003190 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 645127003191 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 645127003192 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 645127003193 dimerization interface [polypeptide binding]; other site 645127003194 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 645127003195 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 645127003196 dimer interface [polypeptide binding]; other site 645127003197 decamer (pentamer of dimers) interface [polypeptide binding]; other site 645127003198 catalytic triad [active] 645127003199 peroxidatic and resolving cysteines [active] 645127003200 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 645127003201 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 645127003202 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645127003203 ABC transporter; Region: ABC_tran; pfam00005 645127003204 Q-loop/lid; other site 645127003205 ABC transporter signature motif; other site 645127003206 Walker B; other site 645127003207 D-loop; other site 645127003208 H-loop/switch region; other site 645127003209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645127003210 multidrug resistance protein MdtH; Provisional; Region: PRK11646 645127003211 putative substrate translocation pore; other site 645127003212 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 645127003213 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 645127003214 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 645127003215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 645127003216 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 645127003217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645127003218 dimer interface [polypeptide binding]; other site 645127003219 conserved gate region; other site 645127003220 ABC-ATPase subunit interface; other site 645127003221 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 645127003222 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 645127003223 ATP binding site [chemical binding]; other site 645127003224 putative Mg++ binding site [ion binding]; other site 645127003225 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645127003226 nucleotide binding region [chemical binding]; other site 645127003227 ATP-binding site [chemical binding]; other site 645127003228 Helicase associated domain (HA2); Region: HA2; pfam04408 645127003229 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 645127003230 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 645127003231 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 645127003232 ATP cone domain; Region: ATP-cone; pfam03477 645127003233 LexA repressor; Validated; Region: PRK00215 645127003234 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 645127003235 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 645127003236 Catalytic site [active] 645127003237 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 645127003238 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 645127003239 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 645127003240 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 645127003241 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 645127003242 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 645127003243 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 645127003244 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 645127003245 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 645127003246 putative substrate binding site [chemical binding]; other site 645127003247 putative ATP binding site [chemical binding]; other site 645127003248 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 645127003249 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 645127003250 active site 645127003251 phosphorylation site [posttranslational modification] 645127003252 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 645127003253 active site 645127003254 P-loop; other site 645127003255 phosphorylation site [posttranslational modification] 645127003256 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 645127003257 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 645127003258 regulatory protein interface [polypeptide binding]; other site 645127003259 active site 645127003260 regulatory phosphorylation site [posttranslational modification]; other site 645127003261 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 645127003262 GTPases [General function prediction only]; Region: HflX; COG2262 645127003263 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 645127003264 HflX GTPase family; Region: HflX; cd01878 645127003265 G1 box; other site 645127003266 GTP/Mg2+ binding site [chemical binding]; other site 645127003267 Switch I region; other site 645127003268 G2 box; other site 645127003269 G3 box; other site 645127003270 Switch II region; other site 645127003271 G4 box; other site 645127003272 G5 box; other site 645127003273 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 645127003274 G1 box; other site 645127003275 GTP/Mg2+ binding site [chemical binding]; other site 645127003276 G2 box; other site 645127003277 Switch I region; other site 645127003278 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 645127003279 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 645127003280 G3 box; other site 645127003281 Switch II region; other site 645127003282 GTP/Mg2+ binding site [chemical binding]; other site 645127003283 G4 box; other site 645127003284 G5 box; other site 645127003285 Nucleoside recognition; Region: Gate; pfam07670 645127003286 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 645127003287 Nucleoside recognition; Region: Gate; pfam07670 645127003288 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 645127003289 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 645127003290 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 645127003291 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 645127003292 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 645127003293 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 645127003294 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 645127003295 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 645127003296 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 645127003297 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 645127003298 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645127003299 FeS/SAM binding site; other site 645127003300 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 645127003301 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 645127003302 Walker A/P-loop; other site 645127003303 ATP binding site [chemical binding]; other site 645127003304 Q-loop/lid; other site 645127003305 ABC transporter signature motif; other site 645127003306 Walker B; other site 645127003307 D-loop; other site 645127003308 H-loop/switch region; other site 645127003309 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 645127003310 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 645127003311 substrate binding pocket [chemical binding]; other site 645127003312 membrane-bound complex binding site; other site 645127003313 hinge residues; other site 645127003314 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645127003315 dimer interface [polypeptide binding]; other site 645127003316 conserved gate region; other site 645127003317 putative PBP binding loops; other site 645127003318 ABC-ATPase subunit interface; other site 645127003319 recombination regulator RecX; Reviewed; Region: recX; PRK00117 645127003320 recombinase A; Provisional; Region: recA; PRK09354 645127003321 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 645127003322 hexamer interface [polypeptide binding]; other site 645127003323 Walker A motif; other site 645127003324 ATP binding site [chemical binding]; other site 645127003325 Walker B motif; other site 645127003326 BioY family; Region: BioY; pfam02632 645127003327 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 645127003328 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 645127003329 Walker A/P-loop; other site 645127003330 ATP binding site [chemical binding]; other site 645127003331 Q-loop/lid; other site 645127003332 ABC transporter signature motif; other site 645127003333 Walker B; other site 645127003334 D-loop; other site 645127003335 H-loop/switch region; other site 645127003336 Cobalt transport protein; Region: CbiQ; cl00463 645127003337 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 645127003338 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645127003339 non-specific DNA binding site [nucleotide binding]; other site 645127003340 salt bridge; other site 645127003341 sequence-specific DNA binding site [nucleotide binding]; other site 645127003342 Competence-damaged protein; Region: CinA; pfam02464 645127003343 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 645127003344 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 645127003345 UbiA prenyltransferase family; Region: UbiA; pfam01040 645127003346 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 645127003347 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 645127003348 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 645127003349 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 645127003350 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 645127003351 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 645127003352 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 645127003353 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 645127003354 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 645127003355 dimer interface [polypeptide binding]; other site 645127003356 active site 645127003357 catalytic residue [active] 645127003358 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 645127003359 dihydrodipicolinate reductase; Provisional; Region: PRK00048 645127003360 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 645127003361 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 645127003362 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 645127003363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645127003364 dimer interface [polypeptide binding]; other site 645127003365 conserved gate region; other site 645127003366 putative PBP binding loops; other site 645127003367 ABC-ATPase subunit interface; other site 645127003368 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 645127003369 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 645127003370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645127003371 dimer interface [polypeptide binding]; other site 645127003372 conserved gate region; other site 645127003373 putative PBP binding loops; other site 645127003374 ABC-ATPase subunit interface; other site 645127003375 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 645127003376 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 645127003377 Walker A/P-loop; other site 645127003378 ATP binding site [chemical binding]; other site 645127003379 Q-loop/lid; other site 645127003380 ABC transporter signature motif; other site 645127003381 Walker B; other site 645127003382 D-loop; other site 645127003383 H-loop/switch region; other site 645127003384 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 645127003385 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 645127003386 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 645127003387 Walker A/P-loop; other site 645127003388 ATP binding site [chemical binding]; other site 645127003389 Q-loop/lid; other site 645127003390 ABC transporter signature motif; other site 645127003391 Walker B; other site 645127003392 D-loop; other site 645127003393 H-loop/switch region; other site 645127003394 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 645127003395 YwiC-like protein; Region: YwiC; pfam14256 645127003396 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 645127003397 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 645127003398 oligomer interface [polypeptide binding]; other site 645127003399 RNA binding site [nucleotide binding]; other site 645127003400 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 645127003401 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 645127003402 RNase E interface [polypeptide binding]; other site 645127003403 trimer interface [polypeptide binding]; other site 645127003404 active site 645127003405 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 645127003406 putative nucleic acid binding region [nucleotide binding]; other site 645127003407 G-X-X-G motif; other site 645127003408 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 645127003409 RNA binding site [nucleotide binding]; other site 645127003410 domain interface; other site 645127003411 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 645127003412 16S/18S rRNA binding site [nucleotide binding]; other site 645127003413 S13e-L30e interaction site [polypeptide binding]; other site 645127003414 25S rRNA binding site [nucleotide binding]; other site 645127003415 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 645127003416 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 645127003417 active site 645127003418 Riboflavin kinase; Region: Flavokinase; smart00904 645127003419 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 645127003420 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 645127003421 RNA binding site [nucleotide binding]; other site 645127003422 active site 645127003423 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 645127003424 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 645127003425 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 645127003426 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 645127003427 putative efflux protein, MATE family; Region: matE; TIGR00797 645127003428 DHH family; Region: DHH; pfam01368 645127003429 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 645127003430 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 645127003431 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 645127003432 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 645127003433 G1 box; other site 645127003434 putative GEF interaction site [polypeptide binding]; other site 645127003435 GTP/Mg2+ binding site [chemical binding]; other site 645127003436 Switch I region; other site 645127003437 G2 box; other site 645127003438 G3 box; other site 645127003439 Switch II region; other site 645127003440 G4 box; other site 645127003441 G5 box; other site 645127003442 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 645127003443 Translation-initiation factor 2; Region: IF-2; pfam11987 645127003444 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 645127003445 Protein of unknown function (DUF448); Region: DUF448; pfam04296 645127003446 putative RNA binding cleft [nucleotide binding]; other site 645127003447 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 645127003448 NusA N-terminal domain; Region: NusA_N; pfam08529 645127003449 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 645127003450 RNA binding site [nucleotide binding]; other site 645127003451 homodimer interface [polypeptide binding]; other site 645127003452 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 645127003453 G-X-X-G motif; other site 645127003454 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 645127003455 G-X-X-G motif; other site 645127003456 ribosome maturation protein RimP; Reviewed; Region: PRK00092 645127003457 Sm and related proteins; Region: Sm_like; cl00259 645127003458 Sm and related proteins; Region: Sm_like; cl00259 645127003459 heptamer interface [polypeptide binding]; other site 645127003460 Sm1 motif; other site 645127003461 hexamer interface [polypeptide binding]; other site 645127003462 RNA binding site [nucleotide binding]; other site 645127003463 Sm2 motif; other site 645127003464 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 645127003465 dinuclear metal binding motif [ion binding]; other site 645127003466 prolyl-tRNA synthetase; Provisional; Region: PRK09194 645127003467 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 645127003468 dimer interface [polypeptide binding]; other site 645127003469 motif 1; other site 645127003470 active site 645127003471 motif 2; other site 645127003472 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 645127003473 putative deacylase active site [active] 645127003474 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 645127003475 active site 645127003476 motif 3; other site 645127003477 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 645127003478 anticodon binding site; other site 645127003479 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 645127003480 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 645127003481 hypothetical protein; Validated; Region: PRK02101 645127003482 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 645127003483 active site 645127003484 SAM binding site [chemical binding]; other site 645127003485 homodimer interface [polypeptide binding]; other site 645127003486 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 645127003487 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 645127003488 catalytic triad [active] 645127003489 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 645127003490 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 645127003491 Walker A motif; other site 645127003492 homodimer interface [polypeptide binding]; other site 645127003493 ATP binding site [chemical binding]; other site 645127003494 hydroxycobalamin binding site [chemical binding]; other site 645127003495 Walker B motif; other site 645127003496 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 645127003497 metal ion-dependent adhesion site (MIDAS); other site 645127003498 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 645127003499 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645127003500 Walker A motif; other site 645127003501 ATP binding site [chemical binding]; other site 645127003502 Walker B motif; other site 645127003503 arginine finger; other site 645127003504 malate:quinone oxidoreductase; Validated; Region: PRK05257 645127003505 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 645127003506 mycothione reductase; Reviewed; Region: PRK07846 645127003507 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 645127003508 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 645127003509 cobyric acid synthase; Provisional; Region: PRK00784 645127003510 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 645127003511 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 645127003512 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 645127003513 catalytic triad [active] 645127003514 methionine aminopeptidase; Provisional; Region: PRK12318 645127003515 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 645127003516 active site 645127003517 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 645127003518 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 645127003519 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 645127003520 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 645127003521 active site 645127003522 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 645127003523 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 645127003524 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 645127003525 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645127003526 FeS/SAM binding site; other site 645127003527 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 645127003528 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 645127003529 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 645127003530 ribosome recycling factor; Reviewed; Region: frr; PRK00083 645127003531 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 645127003532 hinge region; other site 645127003533 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 645127003534 putative nucleotide binding site [chemical binding]; other site 645127003535 uridine monophosphate binding site [chemical binding]; other site 645127003536 homohexameric interface [polypeptide binding]; other site 645127003537 elongation factor Ts; Provisional; Region: tsf; PRK09377 645127003538 UBA/TS-N domain; Region: UBA; pfam00627 645127003539 Elongation factor TS; Region: EF_TS; pfam00889 645127003540 Elongation factor TS; Region: EF_TS; pfam00889 645127003541 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 645127003542 rRNA interaction site [nucleotide binding]; other site 645127003543 S8 interaction site; other site 645127003544 putative laminin-1 binding site; other site 645127003545 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 645127003546 Peptidase family M23; Region: Peptidase_M23; pfam01551 645127003547 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 645127003548 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 645127003549 active site 645127003550 DNA binding site [nucleotide binding] 645127003551 Int/Topo IB signature motif; other site 645127003552 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 645127003553 DNA protecting protein DprA; Region: dprA; TIGR00732 645127003554 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 645127003555 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 645127003556 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645127003557 Walker A motif; other site 645127003558 ATP binding site [chemical binding]; other site 645127003559 Walker B motif; other site 645127003560 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 645127003561 hypothetical protein; Reviewed; Region: PRK12497 645127003562 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 645127003563 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 645127003564 RNA/DNA hybrid binding site [nucleotide binding]; other site 645127003565 active site 645127003566 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 645127003567 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 645127003568 Catalytic site [active] 645127003569 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 645127003570 Lipase (class 2); Region: Lipase_2; pfam01674 645127003571 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 645127003572 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 645127003573 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 645127003574 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 645127003575 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 645127003576 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 645127003577 RNA binding site [nucleotide binding]; other site 645127003578 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 645127003579 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 645127003580 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 645127003581 RimM N-terminal domain; Region: RimM; pfam01782 645127003582 PRC-barrel domain; Region: PRC; pfam05239 645127003583 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 645127003584 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 645127003585 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 645127003586 signal recognition particle protein; Provisional; Region: PRK10867 645127003587 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 645127003588 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 645127003589 P loop; other site 645127003590 GTP binding site [chemical binding]; other site 645127003591 Signal peptide binding domain; Region: SRP_SPB; pfam02978 645127003592 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 645127003593 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 645127003594 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 645127003595 active site 645127003596 catalytic triad [active] 645127003597 oxyanion hole [active] 645127003598 PII uridylyl-transferase; Provisional; Region: glnD; PRK00227 645127003599 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 645127003600 metal binding triad; other site 645127003601 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 645127003602 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 645127003603 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 645127003604 Nitrogen regulatory protein P-II; Region: P-II; smart00938 645127003605 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 645127003606 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 645127003607 active site 645127003608 oxyanion hole [active] 645127003609 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 645127003610 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 645127003611 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 645127003612 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 645127003613 AAA domain; Region: AAA_23; pfam13476 645127003614 Walker A/P-loop; other site 645127003615 ATP binding site [chemical binding]; other site 645127003616 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 645127003617 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 645127003618 ABC transporter signature motif; other site 645127003619 Walker B; other site 645127003620 D-loop; other site 645127003621 H-loop/switch region; other site 645127003622 Acylphosphatase; Region: Acylphosphatase; cl00551 645127003623 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 645127003624 amino acid carrier protein; Region: agcS; TIGR00835 645127003625 ribonuclease III; Reviewed; Region: rnc; PRK00102 645127003626 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 645127003627 dimerization interface [polypeptide binding]; other site 645127003628 active site 645127003629 metal binding site [ion binding]; metal-binding site 645127003630 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 645127003631 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 645127003632 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 645127003633 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 645127003634 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 645127003635 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 645127003636 active site 645127003637 (T/H)XGH motif; other site 645127003638 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 645127003639 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645127003640 S-adenosylmethionine binding site [chemical binding]; other site 645127003641 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 645127003642 carboxyltransferase (CT) interaction site; other site 645127003643 biotinylation site [posttranslational modification]; other site 645127003644 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 645127003645 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 645127003646 generic binding surface II; other site 645127003647 ssDNA binding site; other site 645127003648 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 645127003649 ATP binding site [chemical binding]; other site 645127003650 putative Mg++ binding site [ion binding]; other site 645127003651 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645127003652 nucleotide binding region [chemical binding]; other site 645127003653 ATP-binding site [chemical binding]; other site 645127003654 DAK2 domain; Region: Dak2; pfam02734 645127003655 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 645127003656 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 645127003657 ligand binding site [chemical binding]; other site 645127003658 active site 645127003659 UGI interface [polypeptide binding]; other site 645127003660 catalytic site [active] 645127003661 thiamine monophosphate kinase; Provisional; Region: PRK05731 645127003662 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 645127003663 ATP binding site [chemical binding]; other site 645127003664 dimerization interface [polypeptide binding]; other site 645127003665 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 645127003666 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 645127003667 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 645127003668 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 645127003669 ATP-grasp domain; Region: ATP-grasp_4; cl17255 645127003670 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 645127003671 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 645127003672 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 645127003673 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 645127003674 active site 645127003675 Ap6A binding site [chemical binding]; other site 645127003676 nudix motif; other site 645127003677 metal binding site [ion binding]; metal-binding site 645127003678 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 645127003679 catalytic core [active] 645127003680 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 645127003681 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 645127003682 substrate binding site [chemical binding]; other site 645127003683 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 645127003684 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 645127003685 substrate binding site [chemical binding]; other site 645127003686 ligand binding site [chemical binding]; other site 645127003687 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 645127003688 Transcriptional regulator [Transcription]; Region: IclR; COG1414 645127003689 Bacterial transcriptional regulator; Region: IclR; pfam01614 645127003690 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 645127003691 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 645127003692 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 645127003693 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 645127003694 Uncharacterized membrane protein [Function unknown]; Region: COG3949 645127003695 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 645127003696 DNA binding residues [nucleotide binding] 645127003697 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 645127003698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645127003699 metabolite-proton symporter; Region: 2A0106; TIGR00883 645127003700 putative substrate translocation pore; other site 645127003701 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 645127003702 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 645127003703 Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea; Region: Creatinase; cd01090 645127003704 active site 645127003705 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 645127003706 Domain of unknown function (DUF955); Region: DUF955; pfam06114 645127003707 integrase; Provisional; Region: int; PHA02601 645127003708 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 645127003709 active site 645127003710 DNA binding site [nucleotide binding] 645127003711 Int/Topo IB signature motif; other site 645127003712 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 645127003713 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 645127003714 HIGH motif; other site 645127003715 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 645127003716 active site 645127003717 KMSKS motif; other site 645127003718 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 645127003719 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 645127003720 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 645127003721 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 645127003722 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 645127003723 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 645127003724 active site 645127003725 catalytic site [active] 645127003726 substrate binding site [chemical binding]; other site 645127003727 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 645127003728 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 645127003729 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 645127003730 metal binding triad; other site 645127003731 benzoate transport; Region: 2A0115; TIGR00895 645127003732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645127003733 putative substrate translocation pore; other site 645127003734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645127003735 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 645127003736 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 645127003737 tartrate dehydrogenase; Region: TTC; TIGR02089 645127003738 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 645127003739 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 645127003740 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 645127003741 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 645127003742 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 645127003743 ligand binding site [chemical binding]; other site 645127003744 NAD binding site [chemical binding]; other site 645127003745 dimerization interface [polypeptide binding]; other site 645127003746 catalytic site [active] 645127003747 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 645127003748 putative L-serine binding site [chemical binding]; other site 645127003749 ketol-acid reductoisomerase; Provisional; Region: PRK05479 645127003750 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 645127003751 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 645127003752 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 645127003753 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 645127003754 putative valine binding site [chemical binding]; other site 645127003755 dimer interface [polypeptide binding]; other site 645127003756 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 645127003757 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 645127003758 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 645127003759 PYR/PP interface [polypeptide binding]; other site 645127003760 dimer interface [polypeptide binding]; other site 645127003761 TPP binding site [chemical binding]; other site 645127003762 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 645127003763 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 645127003764 TPP-binding site [chemical binding]; other site 645127003765 dimer interface [polypeptide binding]; other site 645127003766 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 645127003767 Mechanosensitive ion channel; Region: MS_channel; pfam00924 645127003768 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 645127003769 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 645127003770 Predicted membrane protein [Function unknown]; Region: COG2259 645127003771 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 645127003772 Uncharacterized membrane protein [Function unknown]; Region: COG3949 645127003773 Uncharacterized membrane protein [Function unknown]; Region: COG3949 645127003774 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 645127003775 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 645127003776 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 645127003777 GatB domain; Region: GatB_Yqey; smart00845 645127003778 Uncharacterized membrane protein [Function unknown]; Region: COG3949 645127003779 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 645127003780 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 645127003781 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 645127003782 phosphofructokinase; Region: PFK_mixed; TIGR02483 645127003783 active site 645127003784 ADP/pyrophosphate binding site [chemical binding]; other site 645127003785 dimerization interface [polypeptide binding]; other site 645127003786 allosteric effector site; other site 645127003787 fructose-1,6-bisphosphate binding site; other site 645127003788 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645127003789 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645127003790 putative substrate translocation pore; other site 645127003791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645127003792 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 645127003793 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 645127003794 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 645127003795 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 645127003796 threonine dehydratase; Reviewed; Region: PRK09224 645127003797 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 645127003798 tetramer interface [polypeptide binding]; other site 645127003799 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645127003800 catalytic residue [active] 645127003801 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 645127003802 putative Ile/Val binding site [chemical binding]; other site 645127003803 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 645127003804 putative Ile/Val binding site [chemical binding]; other site 645127003805 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 645127003806 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 645127003807 nucleotide binding pocket [chemical binding]; other site 645127003808 K-X-D-G motif; other site 645127003809 catalytic site [active] 645127003810 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 645127003811 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 645127003812 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 645127003813 Dimer interface [polypeptide binding]; other site 645127003814 BRCT sequence motif; other site 645127003815 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 645127003816 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 645127003817 active site 645127003818 catalytic site [active] 645127003819 substrate binding site [chemical binding]; other site 645127003820 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645127003821 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645127003822 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 645127003823 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 645127003824 Ligand Binding Site [chemical binding]; other site 645127003825 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 645127003826 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 645127003827 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 645127003828 catalytic residue [active] 645127003829 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 645127003830 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 645127003831 Ligand Binding Site [chemical binding]; other site 645127003832 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 645127003833 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 645127003834 Ligand binding site [chemical binding]; other site 645127003835 Electron transfer flavoprotein domain; Region: ETF; pfam01012 645127003836 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 645127003837 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645127003838 Walker A/P-loop; other site 645127003839 ATP binding site [chemical binding]; other site 645127003840 ABC transporter signature motif; other site 645127003841 Walker B; other site 645127003842 D-loop; other site 645127003843 H-loop/switch region; other site 645127003844 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 645127003845 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 645127003846 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 645127003847 active site 645127003848 homodimer interface [polypeptide binding]; other site 645127003849 catalytic site [active] 645127003850 acceptor binding site [chemical binding]; other site 645127003851 glycogen branching enzyme; Provisional; Region: PRK05402 645127003852 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 645127003853 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 645127003854 active site 645127003855 catalytic site [active] 645127003856 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 645127003857 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 645127003858 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 645127003859 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 645127003860 Domain of unknown function DUF77; Region: DUF77; pfam01910 645127003861 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 645127003862 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 645127003863 dimer interface [polypeptide binding]; other site 645127003864 substrate binding site [chemical binding]; other site 645127003865 metal binding site [ion binding]; metal-binding site 645127003866 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 645127003867 hypothetical protein; Provisional; Region: PRK03298 645127003868 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 645127003869 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 645127003870 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 645127003871 gamma subunit interface [polypeptide binding]; other site 645127003872 epsilon subunit interface [polypeptide binding]; other site 645127003873 LBP interface [polypeptide binding]; other site 645127003874 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 645127003875 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 645127003876 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 645127003877 alpha subunit interaction interface [polypeptide binding]; other site 645127003878 Walker A motif; other site 645127003879 ATP binding site [chemical binding]; other site 645127003880 Walker B motif; other site 645127003881 inhibitor binding site; inhibition site 645127003882 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 645127003883 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 645127003884 core domain interface [polypeptide binding]; other site 645127003885 delta subunit interface [polypeptide binding]; other site 645127003886 epsilon subunit interface [polypeptide binding]; other site 645127003887 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 645127003888 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 645127003889 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 645127003890 beta subunit interaction interface [polypeptide binding]; other site 645127003891 Walker A motif; other site 645127003892 ATP binding site [chemical binding]; other site 645127003893 Walker B motif; other site 645127003894 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 645127003895 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 645127003896 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 645127003897 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 645127003898 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 645127003899 F0F1 ATP synthase subunit C; Validated; Region: PRK07874 645127003900 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 645127003901 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 645127003902 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 645127003903 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 645127003904 Mg++ binding site [ion binding]; other site 645127003905 putative catalytic motif [active] 645127003906 substrate binding site [chemical binding]; other site 645127003907 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 645127003908 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 645127003909 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 645127003910 peptide chain release factor 1; Validated; Region: prfA; PRK00591 645127003911 This domain is found in peptide chain release factors; Region: PCRF; smart00937 645127003912 RF-1 domain; Region: RF-1; pfam00472 645127003913 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 645127003914 transcription termination factor Rho; Provisional; Region: PRK12608 645127003915 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 645127003916 RNA binding site [nucleotide binding]; other site 645127003917 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 645127003918 multimer interface [polypeptide binding]; other site 645127003919 Walker A motif; other site 645127003920 ATP binding site [chemical binding]; other site 645127003921 Walker B motif; other site 645127003922 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620 645127003923 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 645127003924 acyl-activating enzyme (AAE) consensus motif; other site 645127003925 AMP binding site [chemical binding]; other site 645127003926 active site 645127003927 CoA binding site [chemical binding]; other site 645127003928 homoserine kinase; Provisional; Region: PRK01212 645127003929 homoserine dehydrogenase; Provisional; Region: PRK06349 645127003930 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 645127003931 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 645127003932 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 645127003933 diaminopimelate decarboxylase; Region: lysA; TIGR01048 645127003934 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 645127003935 active site 645127003936 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 645127003937 substrate binding site [chemical binding]; other site 645127003938 catalytic residues [active] 645127003939 dimer interface [polypeptide binding]; other site 645127003940 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 645127003941 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 645127003942 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 645127003943 active site 645127003944 HIGH motif; other site 645127003945 KMSK motif region; other site 645127003946 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 645127003947 tRNA binding surface [nucleotide binding]; other site 645127003948 anticodon binding site; other site 645127003949 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 645127003950 Cysteine-rich domain; Region: CCG; pfam02754 645127003951 Cysteine-rich domain; Region: CCG; pfam02754 645127003952 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 645127003953 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 645127003954 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 645127003955 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 645127003956 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 645127003957 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 645127003958 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 645127003959 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 645127003960 NAD-dependent deacetylase; Provisional; Region: PRK00481 645127003961 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 645127003962 NAD+ binding site [chemical binding]; other site 645127003963 substrate binding site [chemical binding]; other site 645127003964 Zn binding site [ion binding]; other site 645127003965 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 645127003966 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645127003967 active site 645127003968 motif I; other site 645127003969 motif II; other site 645127003970 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645127003971 motif II; other site 645127003972 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645127003973 Walker A/P-loop; other site 645127003974 ATP binding site [chemical binding]; other site 645127003975 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 645127003976 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 645127003977 active site 645127003978 metal binding site [ion binding]; metal-binding site 645127003979 DNA binding site [nucleotide binding] 645127003980 Uncharacterized conserved protein [Function unknown]; Region: COG4279 645127003981 SNF2 Helicase protein; Region: DUF3670; pfam12419 645127003982 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 645127003983 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 645127003984 ATP binding site [chemical binding]; other site 645127003985 putative Mg++ binding site [ion binding]; other site 645127003986 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645127003987 nucleotide binding region [chemical binding]; other site 645127003988 ATP-binding site [chemical binding]; other site 645127003989 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 645127003990 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 645127003991 Na binding site [ion binding]; other site 645127003992 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 645127003993 Protein of unknown function (DUF989); Region: DUF989; pfam06181 645127003994 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 645127003995 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 645127003996 ATP binding site [chemical binding]; other site 645127003997 Mg++ binding site [ion binding]; other site 645127003998 motif III; other site 645127003999 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645127004000 nucleotide binding region [chemical binding]; other site 645127004001 ATP-binding site [chemical binding]; other site 645127004002 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 645127004003 putative RNA binding site [nucleotide binding]; other site 645127004004 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 645127004005 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 645127004006 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 645127004007 metal binding site 2 [ion binding]; metal-binding site 645127004008 putative DNA binding helix; other site 645127004009 metal binding site 1 [ion binding]; metal-binding site 645127004010 dimer interface [polypeptide binding]; other site 645127004011 structural Zn2+ binding site [ion binding]; other site 645127004012 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 645127004013 diiron binding motif [ion binding]; other site 645127004014 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 645127004015 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 645127004016 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 645127004017 catalytic residue [active] 645127004018 putative FPP diphosphate binding site; other site 645127004019 putative FPP binding hydrophobic cleft; other site 645127004020 dimer interface [polypeptide binding]; other site 645127004021 putative IPP diphosphate binding site; other site 645127004022 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 645127004023 Recombination protein O N terminal; Region: RecO_N; pfam11967 645127004024 Recombination protein O C terminal; Region: RecO_C; pfam02565 645127004025 GTPase Era; Reviewed; Region: era; PRK00089 645127004026 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 645127004027 G1 box; other site 645127004028 GTP/Mg2+ binding site [chemical binding]; other site 645127004029 Switch I region; other site 645127004030 G2 box; other site 645127004031 Switch II region; other site 645127004032 G3 box; other site 645127004033 G4 box; other site 645127004034 G5 box; other site 645127004035 KH domain; Region: KH_2; pfam07650 645127004036 hypothetical protein; Provisional; Region: PRK11573 645127004037 Domain of unknown function DUF21; Region: DUF21; pfam01595 645127004038 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 645127004039 Transporter associated domain; Region: CorC_HlyC; smart01091 645127004040 metal-binding heat shock protein; Provisional; Region: PRK00016 645127004041 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 645127004042 PhoH-like protein; Region: PhoH; pfam02562 645127004043 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 645127004044 RNA methyltransferase, RsmE family; Region: TIGR00046 645127004045 chaperone protein DnaJ; Provisional; Region: PRK14278 645127004046 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 645127004047 HSP70 interaction site [polypeptide binding]; other site 645127004048 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 645127004049 Zn binding sites [ion binding]; other site 645127004050 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 645127004051 dimer interface [polypeptide binding]; other site 645127004052 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 645127004053 coproporphyrinogen III oxidase; Validated; Region: PRK05628 645127004054 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645127004055 FeS/SAM binding site; other site 645127004056 HemN C-terminal domain; Region: HemN_C; pfam06969 645127004057 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 645127004058 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 645127004059 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 645127004060 acyl-activating enzyme (AAE) consensus motif; other site 645127004061 putative AMP binding site [chemical binding]; other site 645127004062 putative active site [active] 645127004063 putative CoA binding site [chemical binding]; other site 645127004064 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 645127004065 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 645127004066 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 645127004067 active site lid residues [active] 645127004068 substrate binding pocket [chemical binding]; other site 645127004069 catalytic residues [active] 645127004070 substrate-Mg2+ binding site; other site 645127004071 aspartate-rich region 1; other site 645127004072 aspartate-rich region 2; other site 645127004073 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 645127004074 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645127004075 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645127004076 homodimer interface [polypeptide binding]; other site 645127004077 catalytic residue [active] 645127004078 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 645127004079 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 645127004080 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 645127004081 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645127004082 dimer interface [polypeptide binding]; other site 645127004083 conserved gate region; other site 645127004084 putative PBP binding loops; other site 645127004085 ABC-ATPase subunit interface; other site 645127004086 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 645127004087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645127004088 dimer interface [polypeptide binding]; other site 645127004089 conserved gate region; other site 645127004090 putative PBP binding loops; other site 645127004091 ABC-ATPase subunit interface; other site 645127004092 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 645127004093 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 645127004094 Walker A/P-loop; other site 645127004095 ATP binding site [chemical binding]; other site 645127004096 Q-loop/lid; other site 645127004097 ABC transporter signature motif; other site 645127004098 Walker B; other site 645127004099 D-loop; other site 645127004100 H-loop/switch region; other site 645127004101 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 645127004102 Walker A/P-loop; other site 645127004103 ATP binding site [chemical binding]; other site 645127004104 Q-loop/lid; other site 645127004105 ABC transporter signature motif; other site 645127004106 Walker B; other site 645127004107 D-loop; other site 645127004108 H-loop/switch region; other site 645127004109 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 645127004110 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 645127004111 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 645127004112 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 645127004113 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 645127004114 GTP-binding protein LepA; Provisional; Region: PRK05433 645127004115 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 645127004116 G1 box; other site 645127004117 putative GEF interaction site [polypeptide binding]; other site 645127004118 GTP/Mg2+ binding site [chemical binding]; other site 645127004119 Switch I region; other site 645127004120 G2 box; other site 645127004121 G3 box; other site 645127004122 Switch II region; other site 645127004123 G4 box; other site 645127004124 G5 box; other site 645127004125 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 645127004126 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 645127004127 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 645127004128 PemK-like protein; Region: PemK; pfam02452 645127004129 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 645127004130 hypothetical protein; Validated; Region: PRK05629 645127004131 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 645127004132 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 645127004133 Competence protein; Region: Competence; pfam03772 645127004134 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 645127004135 Helix-hairpin-helix motif; Region: HHH; pfam00633 645127004136 helix-hairpin-helix signature motif; other site 645127004137 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 645127004138 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 645127004139 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 645127004140 catalytic core [active] 645127004141 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 645127004142 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 645127004143 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 645127004144 active site 645127004145 (T/H)XGH motif; other site 645127004146 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 645127004147 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 645127004148 putative catalytic cysteine [active] 645127004149 gamma-glutamyl kinase; Provisional; Region: PRK05429 645127004150 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 645127004151 nucleotide binding site [chemical binding]; other site 645127004152 homotetrameric interface [polypeptide binding]; other site 645127004153 putative phosphate binding site [ion binding]; other site 645127004154 putative allosteric binding site; other site 645127004155 PUA domain; Region: PUA; pfam01472 645127004156 GTPase CgtA; Reviewed; Region: obgE; PRK12296 645127004157 GTP1/OBG; Region: GTP1_OBG; pfam01018 645127004158 Obg GTPase; Region: Obg; cd01898 645127004159 G1 box; other site 645127004160 GTP/Mg2+ binding site [chemical binding]; other site 645127004161 Switch I region; other site 645127004162 G2 box; other site 645127004163 G3 box; other site 645127004164 Switch II region; other site 645127004165 G4 box; other site 645127004166 G5 box; other site 645127004167 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 645127004168 lysine transporter; Provisional; Region: PRK10836 645127004169 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 645127004170 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 645127004171 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 645127004172 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 645127004173 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 645127004174 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 645127004175 homodimer interface [polypeptide binding]; other site 645127004176 oligonucleotide binding site [chemical binding]; other site 645127004177 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 645127004178 active site 645127004179 multimer interface [polypeptide binding]; other site 645127004180 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 645127004181 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 645127004182 Walker A/P-loop; other site 645127004183 ATP binding site [chemical binding]; other site 645127004184 Q-loop/lid; other site 645127004185 ABC transporter signature motif; other site 645127004186 Walker B; other site 645127004187 D-loop; other site 645127004188 H-loop/switch region; other site 645127004189 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 645127004190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645127004191 dimer interface [polypeptide binding]; other site 645127004192 conserved gate region; other site 645127004193 putative PBP binding loops; other site 645127004194 ABC-ATPase subunit interface; other site 645127004195 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 645127004196 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 645127004197 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 645127004198 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 645127004199 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 645127004200 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 645127004201 active site 645127004202 HIGH motif; other site 645127004203 nucleotide binding site [chemical binding]; other site 645127004204 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 645127004205 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 645127004206 active site 645127004207 KMSKS motif; other site 645127004208 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 645127004209 tRNA binding surface [nucleotide binding]; other site 645127004210 anticodon binding site; other site 645127004211 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 645127004212 malate dehydrogenase; Provisional; Region: PRK05442 645127004213 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 645127004214 NAD(P) binding site [chemical binding]; other site 645127004215 dimer interface [polypeptide binding]; other site 645127004216 malate binding site [chemical binding]; other site 645127004217 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645127004218 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645127004219 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 645127004220 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 645127004221 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645127004222 Walker A motif; other site 645127004223 ATP binding site [chemical binding]; other site 645127004224 Walker B motif; other site 645127004225 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 645127004226 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 645127004227 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 645127004228 oligomer interface [polypeptide binding]; other site 645127004229 active site residues [active] 645127004230 Clp protease; Region: CLP_protease; pfam00574 645127004231 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 645127004232 oligomer interface [polypeptide binding]; other site 645127004233 active site residues [active] 645127004234 trigger factor; Provisional; Region: tig; PRK01490 645127004235 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 645127004236 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 645127004237 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 645127004238 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645127004239 Walker A/P-loop; other site 645127004240 ATP binding site [chemical binding]; other site 645127004241 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 645127004242 ABC transporter; Region: ABC_tran_2; pfam12848 645127004243 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 645127004244 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 645127004245 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 645127004246 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 645127004247 catalytic residues [active] 645127004248 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 645127004249 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 645127004250 Zn binding site [ion binding]; other site 645127004251 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 645127004252 active site 645127004253 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 645127004254 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645127004255 Walker A/P-loop; other site 645127004256 ATP binding site [chemical binding]; other site 645127004257 Q-loop/lid; other site 645127004258 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 645127004259 ABC transporter; Region: ABC_tran_2; pfam12848 645127004260 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 645127004261 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 645127004262 Ferritin-like domain; Region: Ferritin; pfam00210 645127004263 dimerization interface [polypeptide binding]; other site 645127004264 DPS ferroxidase diiron center [ion binding]; other site 645127004265 ion pore; other site 645127004266 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 645127004267 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 645127004268 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 645127004269 MarR family; Region: MarR_2; cl17246 645127004270 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 645127004271 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 645127004272 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 645127004273 Nucleoside recognition; Region: Gate; pfam07670 645127004274 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 645127004275 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 645127004276 active site 645127004277 catalytic motif [active] 645127004278 Zn binding site [ion binding]; other site 645127004279 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 645127004280 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 645127004281 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 645127004282 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 645127004283 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 645127004284 intersubunit interface [polypeptide binding]; other site 645127004285 active site 645127004286 catalytic residue [active] 645127004287 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 645127004288 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 645127004289 active site 645127004290 substrate binding site [chemical binding]; other site 645127004291 metal binding site [ion binding]; metal-binding site 645127004292 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 645127004293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 645127004294 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 645127004295 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 645127004296 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 645127004297 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 645127004298 active site 645127004299 motif I; other site 645127004300 motif II; other site 645127004301 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 645127004302 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 645127004303 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 645127004304 catalytic site [active] 645127004305 putative active site [active] 645127004306 putative substrate binding site [chemical binding]; other site 645127004307 dimer interface [polypeptide binding]; other site 645127004308 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 645127004309 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 645127004310 catalytic triad [active] 645127004311 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 645127004312 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 645127004313 catalytic triad [active] 645127004314 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 645127004315 Glucitol operon activator protein (GutM); Region: GutM; cl01890 645127004316 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 645127004317 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 645127004318 dimerization interface [polypeptide binding]; other site 645127004319 active site 645127004320 ribonuclease PH; Reviewed; Region: rph; PRK00173 645127004321 Ribonuclease PH; Region: RNase_PH_bact; cd11362 645127004322 hexamer interface [polypeptide binding]; other site 645127004323 active site 645127004324 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 645127004325 glutamate racemase; Provisional; Region: PRK00865 645127004326 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 645127004327 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 645127004328 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 645127004329 active site 645127004330 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 645127004331 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 645127004332 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 645127004333 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 645127004334 dimer interface [polypeptide binding]; other site 645127004335 putative active site [active] 645127004336 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 645127004337 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 645127004338 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 645127004339 phosphoserine phosphatase SerB; Region: serB; TIGR00338 645127004340 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645127004341 motif II; other site 645127004342 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 645127004343 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 645127004344 D-pathway; other site 645127004345 Putative ubiquinol binding site [chemical binding]; other site 645127004346 Low-spin heme (heme b) binding site [chemical binding]; other site 645127004347 Putative water exit pathway; other site 645127004348 Binuclear center (heme o3/CuB) [ion binding]; other site 645127004349 K-pathway; other site 645127004350 Putative proton exit pathway; other site 645127004351 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 645127004352 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 645127004353 dimer interface [polypeptide binding]; other site 645127004354 putative radical transfer pathway; other site 645127004355 diiron center [ion binding]; other site 645127004356 tyrosyl radical; other site 645127004357 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 645127004358 Ferritin-like domain; Region: Ferritin; pfam00210 645127004359 ferroxidase diiron center [ion binding]; other site 645127004360 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 645127004361 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 645127004362 Class I ribonucleotide reductase; Region: RNR_I; cd01679 645127004363 active site 645127004364 dimer interface [polypeptide binding]; other site 645127004365 catalytic residues [active] 645127004366 effector binding site; other site 645127004367 R2 peptide binding site; other site 645127004368 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 645127004369 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 645127004370 catalytic residues [active] 645127004371 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 645127004372 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 645127004373 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 645127004374 homodimer interface [polypeptide binding]; other site 645127004375 NAD binding pocket [chemical binding]; other site 645127004376 ATP binding pocket [chemical binding]; other site 645127004377 Mg binding site [ion binding]; other site 645127004378 active-site loop [active] 645127004379 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 645127004380 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 645127004381 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645127004382 Walker A/P-loop; other site 645127004383 ATP binding site [chemical binding]; other site 645127004384 Q-loop/lid; other site 645127004385 ABC transporter signature motif; other site 645127004386 Walker B; other site 645127004387 D-loop; other site 645127004388 H-loop/switch region; other site 645127004389 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 645127004390 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 645127004391 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 645127004392 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 645127004393 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 645127004394 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 645127004395 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 645127004396 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 645127004397 acetoin reductase; Validated; Region: PRK08643 645127004398 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 645127004399 NAD binding site [chemical binding]; other site 645127004400 homotetramer interface [polypeptide binding]; other site 645127004401 homodimer interface [polypeptide binding]; other site 645127004402 active site 645127004403 substrate binding site [chemical binding]; other site 645127004404 phosphoglucomutase; Validated; Region: PRK07564 645127004405 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 645127004406 active site 645127004407 substrate binding site [chemical binding]; other site 645127004408 metal binding site [ion binding]; metal-binding site 645127004409 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 645127004410 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 645127004411 catalytic residues [active] 645127004412 Methylamine utilisation protein MauE; Region: MauE; pfam07291 645127004413 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 645127004414 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 645127004415 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 645127004416 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 645127004417 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 645127004418 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 645127004419 dimerization interface [polypeptide binding]; other site 645127004420 putative DNA binding site [nucleotide binding]; other site 645127004421 putative Zn2+ binding site [ion binding]; other site 645127004422 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 645127004423 Cadmium resistance transporter; Region: Cad; pfam03596 645127004424 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 645127004425 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 645127004426 active site 645127004427 catalytic residues [active] 645127004428 DNA binding site [nucleotide binding] 645127004429 Int/Topo IB signature motif; other site 645127004430 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 645127004431 SmpB-tmRNA interface; other site 645127004432 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 645127004433 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 645127004434 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 645127004435 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645127004436 Walker A/P-loop; other site 645127004437 ATP binding site [chemical binding]; other site 645127004438 Q-loop/lid; other site 645127004439 ABC transporter signature motif; other site 645127004440 Walker B; other site 645127004441 D-loop; other site 645127004442 H-loop/switch region; other site 645127004443 peptide chain release factor 2; Validated; Region: prfB; PRK00578 645127004444 This domain is found in peptide chain release factors; Region: PCRF; smart00937 645127004445 RF-1 domain; Region: RF-1; pfam00472 645127004446 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 645127004447 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 645127004448 active site 645127004449 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 645127004450 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 645127004451 active site 645127004452 Acyltransferase family; Region: Acyl_transf_3; pfam01757 645127004453 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 645127004454 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 645127004455 active site 645127004456 catalytic triad [active] 645127004457 oxyanion hole [active] 645127004458 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 645127004459 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 645127004460 NAD(P) binding site [chemical binding]; other site 645127004461 active site 645127004462 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 645127004463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645127004464 dimer interface [polypeptide binding]; other site 645127004465 conserved gate region; other site 645127004466 putative PBP binding loops; other site 645127004467 ABC-ATPase subunit interface; other site 645127004468 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 645127004469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645127004470 dimer interface [polypeptide binding]; other site 645127004471 conserved gate region; other site 645127004472 ABC-ATPase subunit interface; other site 645127004473 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645127004474 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 645127004475 Q-loop/lid; other site 645127004476 ABC transporter signature motif; other site 645127004477 Walker B; other site 645127004478 D-loop; other site 645127004479 H-loop/switch region; other site 645127004480 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 645127004481 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 645127004482 Walker A/P-loop; other site 645127004483 ATP binding site [chemical binding]; other site 645127004484 Q-loop/lid; other site 645127004485 ABC transporter signature motif; other site 645127004486 Walker B; other site 645127004487 D-loop; other site 645127004488 H-loop/switch region; other site 645127004489 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 645127004490 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 645127004491 Walker A/P-loop; other site 645127004492 ATP binding site [chemical binding]; other site 645127004493 Q-loop/lid; other site 645127004494 ABC transporter signature motif; other site 645127004495 Walker B; other site 645127004496 D-loop; other site 645127004497 H-loop/switch region; other site 645127004498 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 645127004499 ABC-2 type transporter; Region: ABC2_membrane; cl17235 645127004500 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645127004501 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645127004502 hypothetical protein; Validated; Region: PRK00068 645127004503 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 645127004504 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 645127004505 Predicted membrane protein [Function unknown]; Region: COG1511 645127004506 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 645127004507 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 645127004508 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 645127004509 PDZ domain; Region: PDZ_2; pfam13180 645127004510 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 645127004511 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 645127004512 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 645127004513 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 645127004514 FMN binding site [chemical binding]; other site 645127004515 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 645127004516 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 645127004517 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 645127004518 putative dimer interface [polypeptide binding]; other site 645127004519 active site pocket [active] 645127004520 putative cataytic base [active] 645127004521 Protein of unknown function DUF45; Region: DUF45; cl00636 645127004522 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 645127004523 Part of AAA domain; Region: AAA_19; pfam13245 645127004524 Family description; Region: UvrD_C_2; pfam13538 645127004525 HRDC domain; Region: HRDC; pfam00570 645127004526 Ion channel; Region: Ion_trans_2; pfam07885 645127004527 TrkA-N domain; Region: TrkA_N; pfam02254 645127004528 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 645127004529 Part of AAA domain; Region: AAA_19; pfam13245 645127004530 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 645127004531 Family description; Region: UvrD_C_2; pfam13538 645127004532 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 645127004533 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 645127004534 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 645127004535 TIGR02569 family protein; Region: TIGR02569_actnb 645127004536 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 645127004537 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 645127004538 helicase 45; Provisional; Region: PTZ00424 645127004539 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 645127004540 ATP binding site [chemical binding]; other site 645127004541 Mg++ binding site [ion binding]; other site 645127004542 motif III; other site 645127004543 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645127004544 nucleotide binding region [chemical binding]; other site 645127004545 ATP-binding site [chemical binding]; other site 645127004546 Transcription factor WhiB; Region: Whib; pfam02467 645127004547 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 645127004548 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 645127004549 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 645127004550 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 645127004551 DNA binding residues [nucleotide binding] 645127004552 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 645127004553 putative deacylase active site [active] 645127004554 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 645127004555 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 645127004556 hinge; other site 645127004557 active site 645127004558 Predicted GTPases [General function prediction only]; Region: COG1162 645127004559 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 645127004560 GTPase/Zn-binding domain interface [polypeptide binding]; other site 645127004561 GTP/Mg2+ binding site [chemical binding]; other site 645127004562 G4 box; other site 645127004563 G5 box; other site 645127004564 G1 box; other site 645127004565 Switch I region; other site 645127004566 G2 box; other site 645127004567 G3 box; other site 645127004568 Switch II region; other site 645127004569 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 645127004570 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 645127004571 putative ion selectivity filter; other site 645127004572 putative pore gating glutamate residue; other site 645127004573 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 645127004574 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 645127004575 Cl- selectivity filter; other site 645127004576 Cl- binding residues [ion binding]; other site 645127004577 pore gating glutamate residue; other site 645127004578 dimer interface [polypeptide binding]; other site 645127004579 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 645127004580 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645127004581 motif II; other site 645127004582 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 645127004583 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 645127004584 ATP binding site [chemical binding]; other site 645127004585 putative Mg++ binding site [ion binding]; other site 645127004586 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 645127004587 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 645127004588 nucleotide binding region [chemical binding]; other site 645127004589 ATP-binding site [chemical binding]; other site 645127004590 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 645127004591 30S subunit binding site; other site 645127004592 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 645127004593 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 645127004594 active site 645127004595 lipoprotein LpqB; Provisional; Region: PRK13616 645127004596 Sporulation and spore germination; Region: Germane; pfam10646 645127004597 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645127004598 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 645127004599 dimerization interface [polypeptide binding]; other site 645127004600 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645127004601 dimer interface [polypeptide binding]; other site 645127004602 phosphorylation site [posttranslational modification] 645127004603 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645127004604 ATP binding site [chemical binding]; other site 645127004605 Mg2+ binding site [ion binding]; other site 645127004606 G-X-G motif; other site 645127004607 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645127004608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645127004609 active site 645127004610 phosphorylation site [posttranslational modification] 645127004611 intermolecular recognition site; other site 645127004612 dimerization interface [polypeptide binding]; other site 645127004613 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645127004614 DNA binding site [nucleotide binding] 645127004615 6-carboxyhexanoate--CoA ligase; Region: BioW; cl00625 645127004616 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 645127004617 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 645127004618 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 645127004619 catalytic residue [active] 645127004620 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 645127004621 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 645127004622 TMP-binding site; other site 645127004623 ATP-binding site [chemical binding]; other site 645127004624 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 645127004625 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 645127004626 S-ribosylhomocysteinase; Provisional; Region: PRK02260 645127004627 Phosphomannose isomerase type I; Region: PMI_typeI; pfam01238 645127004628 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 645127004629 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 645127004630 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 645127004631 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 645127004632 active site 645127004633 substrate binding site [chemical binding]; other site 645127004634 metal binding site [ion binding]; metal-binding site 645127004635 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 645127004636 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 645127004637 Transcription factor WhiB; Region: Whib; pfam02467 645127004638 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 645127004639 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 645127004640 active site 645127004641 Substrate binding site; other site 645127004642 Mg++ binding site; other site 645127004643 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 645127004644 putative trimer interface [polypeptide binding]; other site 645127004645 putative CoA binding site [chemical binding]; other site 645127004646 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 645127004647 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 645127004648 Probable Catalytic site; other site 645127004649 metal-binding site 645127004650 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 645127004651 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 645127004652 NADP binding site [chemical binding]; other site 645127004653 active site 645127004654 putative substrate binding site [chemical binding]; other site 645127004655 Transcriptional regulator [Transcription]; Region: LytR; COG1316 645127004656 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 645127004657 TIGR03089 family protein; Region: TIGR03089 645127004658 Predicted membrane protein [Function unknown]; Region: COG2259 645127004659 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 645127004660 putative active site [active] 645127004661 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 645127004662 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 645127004663 ATP-grasp domain; Region: ATP-grasp; pfam02222 645127004664 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 645127004665 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 645127004666 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 645127004667 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 645127004668 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 645127004669 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 645127004670 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 645127004671 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 645127004672 active site 645127004673 dimer interface [polypeptide binding]; other site 645127004674 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 645127004675 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 645127004676 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 645127004677 Walker A/P-loop; other site 645127004678 ATP binding site [chemical binding]; other site 645127004679 Q-loop/lid; other site 645127004680 ABC transporter signature motif; other site 645127004681 Walker B; other site 645127004682 D-loop; other site 645127004683 H-loop/switch region; other site 645127004684 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645127004685 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 645127004686 Walker A/P-loop; other site 645127004687 ATP binding site [chemical binding]; other site 645127004688 Q-loop/lid; other site 645127004689 ABC transporter signature motif; other site 645127004690 Walker B; other site 645127004691 D-loop; other site 645127004692 H-loop/switch region; other site 645127004693 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 645127004694 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 645127004695 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 645127004696 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645127004697 Walker A/P-loop; other site 645127004698 ATP binding site [chemical binding]; other site 645127004699 Q-loop/lid; other site 645127004700 ABC transporter signature motif; other site 645127004701 Walker B; other site 645127004702 D-loop; other site 645127004703 H-loop/switch region; other site 645127004704 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 645127004705 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 645127004706 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645127004707 Walker A/P-loop; other site 645127004708 ATP binding site [chemical binding]; other site 645127004709 Q-loop/lid; other site 645127004710 ABC transporter signature motif; other site 645127004711 Walker B; other site 645127004712 D-loop; other site 645127004713 H-loop/switch region; other site 645127004714 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645127004715 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 645127004716 glutathione synthetase, prokaryotic; Region: glut_syn; TIGR01380 645127004717 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 645127004718 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 645127004719 active site residue [active] 645127004720 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 645127004721 active site residue [active] 645127004722 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 645127004723 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 645127004724 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 645127004725 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 645127004726 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 645127004727 carboxyltransferase (CT) interaction site; other site 645127004728 biotinylation site [posttranslational modification]; other site 645127004729 xanthine permease; Region: pbuX; TIGR03173 645127004730 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 645127004731 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 645127004732 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 645127004733 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 645127004734 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 645127004735 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 645127004736 active site 645127004737 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 645127004738 NlpC/P60 family; Region: NLPC_P60; pfam00877 645127004739 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 645127004740 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 645127004741 Walker A/P-loop; other site 645127004742 ATP binding site [chemical binding]; other site 645127004743 Q-loop/lid; other site 645127004744 ABC transporter signature motif; other site 645127004745 Walker B; other site 645127004746 D-loop; other site 645127004747 H-loop/switch region; other site 645127004748 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 645127004749 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 645127004750 TM-ABC transporter signature motif; other site 645127004751 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 645127004752 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 645127004753 putative ligand binding site [chemical binding]; other site 645127004754 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 645127004755 adenosine deaminase; Provisional; Region: PRK09358 645127004756 active site 645127004757 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 645127004758 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 645127004759 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 645127004760 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 645127004761 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 645127004762 active site 645127004763 HIGH motif; other site 645127004764 dimer interface [polypeptide binding]; other site 645127004765 KMSKS motif; other site 645127004766 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 645127004767 putative catalytic site [active] 645127004768 putative metal binding site [ion binding]; other site 645127004769 putative phosphate binding site [ion binding]; other site 645127004770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645127004771 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645127004772 putative substrate translocation pore; other site 645127004773 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 645127004774 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 645127004775 active site 645127004776 DNA binding site [nucleotide binding] 645127004777 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 645127004778 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645127004779 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645127004780 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 645127004781 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 645127004782 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 645127004783 Aspartase; Region: Aspartase; cd01357 645127004784 active sites [active] 645127004785 tetramer interface [polypeptide binding]; other site 645127004786 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05613 645127004787 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 645127004788 homodimer interface [polypeptide binding]; other site 645127004789 substrate-cofactor binding pocket; other site 645127004790 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645127004791 catalytic residue [active] 645127004792 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 645127004793 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 645127004794 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 645127004795 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 645127004796 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 645127004797 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 645127004798 FeoA domain; Region: FeoA; pfam04023 645127004799 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 645127004800 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 645127004801 metal binding site [ion binding]; metal-binding site 645127004802 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 645127004803 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 645127004804 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 645127004805 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 645127004806 ABC-ATPase subunit interface; other site 645127004807 dimer interface [polypeptide binding]; other site 645127004808 putative PBP binding regions; other site 645127004809 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 645127004810 glutaminase; Provisional; Region: PRK00971 645127004811 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 645127004812 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 645127004813 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645127004814 Coenzyme A binding pocket [chemical binding]; other site 645127004815 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 645127004816 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 645127004817 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 645127004818 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 645127004819 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 645127004820 homodimer interface [polypeptide binding]; other site 645127004821 NADP binding site [chemical binding]; other site 645127004822 substrate binding site [chemical binding]; other site 645127004823 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 645127004824 Phage Terminase; Region: Terminase_1; pfam03354 645127004825 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 645127004826 proteasome ATPase; Region: pup_AAA; TIGR03689 645127004827 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 645127004828 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 645127004829 tape measure domain; Region: tape_meas_nterm; TIGR02675 645127004830 Phage-related protein [Function unknown]; Region: COG5412 645127004831 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 645127004832 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 645127004833 N-acetyl-D-glucosamine binding site [chemical binding]; other site 645127004834 catalytic residue [active] 645127004835 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 645127004836 active site 645127004837 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 645127004838 active site 645127004839 catalytic triad [active] 645127004840 oxyanion hole [active] 645127004841 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 645127004842 oxyanion hole [active] 645127004843 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 645127004844 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 645127004845 DTAP/Switch II; other site 645127004846 Switch I; other site 645127004847 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 645127004848 P loop; other site 645127004849 Nucleotide binding site [chemical binding]; other site 645127004850 DTAP/Switch II; other site 645127004851 Switch I; other site 645127004852 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 645127004853 dimerization interface [polypeptide binding]; other site 645127004854 putative DNA binding site [nucleotide binding]; other site 645127004855 putative Zn2+ binding site [ion binding]; other site 645127004856 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 645127004857 Low molecular weight phosphatase family; Region: LMWPc; cl00105 645127004858 active site 645127004859 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 645127004860 Domain of unknown function (DUF955); Region: DUF955; pfam06114 645127004861 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 645127004862 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 645127004863 dimer interface [polypeptide binding]; other site 645127004864 ssDNA binding site [nucleotide binding]; other site 645127004865 tetramer (dimer of dimers) interface [polypeptide binding]; other site 645127004866 Helix-turn-helix domain; Region: HTH_36; pfam13730 645127004867 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 645127004868 active site 645127004869 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 645127004870 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 645127004871 BRO family, N-terminal domain; Region: Bro-N; pfam02498 645127004872 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 645127004873 Domain of unknown function (DUF955); Region: DUF955; pfam06114 645127004874 Virulence protein [General function prediction only]; Region: COG3943 645127004875 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 645127004876 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 645127004877 active site 645127004878 DNA binding site [nucleotide binding] 645127004879 Int/Topo IB signature motif; other site 645127004880 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 645127004881 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 645127004882 active site 645127004883 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 645127004884 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 645127004885 active site 645127004886 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 645127004887 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 645127004888 dimer interface [polypeptide binding]; other site 645127004889 putative anticodon binding site; other site 645127004890 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 645127004891 motif 1; other site 645127004892 dimer interface [polypeptide binding]; other site 645127004893 active site 645127004894 motif 2; other site 645127004895 motif 3; other site 645127004896 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 645127004897 pantoate--beta-alanine ligase; Region: panC; TIGR00018 645127004898 active site 645127004899 nucleotide binding site [chemical binding]; other site 645127004900 HIGH motif; other site 645127004901 KMSKS motif; other site 645127004902 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 645127004903 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 645127004904 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 645127004905 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 645127004906 homooctamer interface [polypeptide binding]; other site 645127004907 active site 645127004908 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 645127004909 catalytic center binding site [active] 645127004910 ATP binding site [chemical binding]; other site 645127004911 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 645127004912 dihydropteroate synthase; Region: DHPS; TIGR01496 645127004913 substrate binding pocket [chemical binding]; other site 645127004914 dimer interface [polypeptide binding]; other site 645127004915 inhibitor binding site; inhibition site 645127004916 GTP cyclohydrolase I; Provisional; Region: PLN03044 645127004917 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 645127004918 homodecamer interface [polypeptide binding]; other site 645127004919 active site 645127004920 putative catalytic site residues [active] 645127004921 zinc binding site [ion binding]; other site 645127004922 GTP-CH-I/GFRP interaction surface; other site 645127004923 FtsH Extracellular; Region: FtsH_ext; pfam06480 645127004924 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 645127004925 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645127004926 Walker A motif; other site 645127004927 ATP binding site [chemical binding]; other site 645127004928 Walker B motif; other site 645127004929 arginine finger; other site 645127004930 Peptidase family M41; Region: Peptidase_M41; pfam01434 645127004931 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 645127004932 active site 645127004933 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 645127004934 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 645127004935 Ligand Binding Site [chemical binding]; other site 645127004936 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 645127004937 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 645127004938 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 645127004939 dimer interface [polypeptide binding]; other site 645127004940 substrate binding site [chemical binding]; other site 645127004941 metal binding sites [ion binding]; metal-binding site 645127004942 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 645127004943 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645127004944 putative substrate translocation pore; other site 645127004945 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 645127004946 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 645127004947 Walker A/P-loop; other site 645127004948 ATP binding site [chemical binding]; other site 645127004949 Q-loop/lid; other site 645127004950 ABC transporter signature motif; other site 645127004951 Walker B; other site 645127004952 D-loop; other site 645127004953 H-loop/switch region; other site 645127004954 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 645127004955 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 645127004956 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 645127004957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645127004958 dimer interface [polypeptide binding]; other site 645127004959 conserved gate region; other site 645127004960 putative PBP binding loops; other site 645127004961 ABC-ATPase subunit interface; other site 645127004962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645127004963 dimer interface [polypeptide binding]; other site 645127004964 conserved gate region; other site 645127004965 putative PBP binding loops; other site 645127004966 ABC-ATPase subunit interface; other site 645127004967 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 645127004968 active site residue [active] 645127004969 MarR family; Region: MarR; pfam01047 645127004970 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 645127004971 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 645127004972 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 645127004973 active site 645127004974 CoA binding site [chemical binding]; other site 645127004975 AMP binding site [chemical binding]; other site 645127004976 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 645127004977 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 645127004978 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 645127004979 ring oligomerisation interface [polypeptide binding]; other site 645127004980 ATP/Mg binding site [chemical binding]; other site 645127004981 stacking interactions; other site 645127004982 hinge regions; other site 645127004983 hypothetical protein; Provisional; Region: PRK07907 645127004984 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 645127004985 active site 645127004986 metal binding site [ion binding]; metal-binding site 645127004987 dimer interface [polypeptide binding]; other site 645127004988 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 645127004989 carboxylate-amine ligase; Provisional; Region: PRK13517 645127004990 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 645127004991 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 645127004992 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 645127004993 active site 645127004994 catalytic residues [active] 645127004995 metal binding site [ion binding]; metal-binding site 645127004996 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 645127004997 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645127004998 Coenzyme A binding pocket [chemical binding]; other site 645127004999 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 645127005000 putative catalytic site [active] 645127005001 putative phosphate binding site [ion binding]; other site 645127005002 active site 645127005003 metal binding site A [ion binding]; metal-binding site 645127005004 DNA binding site [nucleotide binding] 645127005005 putative AP binding site [nucleotide binding]; other site 645127005006 putative metal binding site B [ion binding]; other site 645127005007 Transcriptional regulators [Transcription]; Region: MarR; COG1846 645127005008 MarR family; Region: MarR_2; pfam12802 645127005009 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 645127005010 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 645127005011 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 645127005012 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 645127005013 Walker A/P-loop; other site 645127005014 ATP binding site [chemical binding]; other site 645127005015 Q-loop/lid; other site 645127005016 ABC transporter signature motif; other site 645127005017 Walker B; other site 645127005018 D-loop; other site 645127005019 H-loop/switch region; other site 645127005020 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 645127005021 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 645127005022 substrate binding pocket [chemical binding]; other site 645127005023 membrane-bound complex binding site; other site 645127005024 hinge residues; other site 645127005025 Protein kinase domain; Region: Pkinase; pfam00069 645127005026 Catalytic domain of Protein Kinases; Region: PKc; cd00180 645127005027 active site 645127005028 ATP binding site [chemical binding]; other site 645127005029 substrate binding site [chemical binding]; other site 645127005030 activation loop (A-loop); other site 645127005031 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 645127005032 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 645127005033 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 645127005034 propionate/acetate kinase; Provisional; Region: PRK12379 645127005035 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 645127005036 ferredoxin-NADP+ reductase; Region: PLN02852 645127005037 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 645127005038 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 645127005039 putative active site [active] 645127005040 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 645127005041 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 645127005042 CysD dimerization site [polypeptide binding]; other site 645127005043 G1 box; other site 645127005044 putative GEF interaction site [polypeptide binding]; other site 645127005045 GTP/Mg2+ binding site [chemical binding]; other site 645127005046 Switch I region; other site 645127005047 G2 box; other site 645127005048 G3 box; other site 645127005049 Switch II region; other site 645127005050 G4 box; other site 645127005051 G5 box; other site 645127005052 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 645127005053 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 645127005054 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 645127005055 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 645127005056 Active Sites [active] 645127005057 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 645127005058 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 645127005059 Active Sites [active] 645127005060 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 645127005061 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 645127005062 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 645127005063 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 645127005064 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 645127005065 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 645127005066 active site turn [active] 645127005067 phosphorylation site [posttranslational modification] 645127005068 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 645127005069 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 645127005070 HPr interaction site; other site 645127005071 glycerol kinase (GK) interaction site [polypeptide binding]; other site 645127005072 active site 645127005073 phosphorylation site [posttranslational modification] 645127005074 Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251 645127005075 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 645127005076 substrate binding [chemical binding]; other site 645127005077 active site 645127005078 amino acid transporter; Region: 2A0306; TIGR00909 645127005079 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 645127005080 LDH/MDH dimer interface [polypeptide binding]; other site 645127005081 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 645127005082 NAD(P) binding site [chemical binding]; other site 645127005083 substrate binding site [chemical binding]; other site 645127005084 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645127005085 Coenzyme A binding pocket [chemical binding]; other site 645127005086 DinB superfamily; Region: DinB_2; pfam12867 645127005087 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 645127005088 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 645127005089 ATP binding site [chemical binding]; other site 645127005090 substrate binding site [chemical binding]; other site 645127005091 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 645127005092 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 645127005093 Walker A/P-loop; other site 645127005094 ATP binding site [chemical binding]; other site 645127005095 Q-loop/lid; other site 645127005096 ABC transporter signature motif; other site 645127005097 Walker B; other site 645127005098 D-loop; other site 645127005099 H-loop/switch region; other site 645127005100 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 645127005101 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 645127005102 Histidine kinase; Region: HisKA_3; pfam07730 645127005103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 645127005104 ATP binding site [chemical binding]; other site 645127005105 Mg2+ binding site [ion binding]; other site 645127005106 G-X-G motif; other site 645127005107 Response regulator receiver domain; Region: Response_reg; pfam00072 645127005108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645127005109 active site 645127005110 phosphorylation site [posttranslational modification] 645127005111 intermolecular recognition site; other site 645127005112 dimerization interface [polypeptide binding]; other site 645127005113 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 645127005114 DNA binding residues [nucleotide binding] 645127005115 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 645127005116 ThiC-associated domain; Region: ThiC-associated; pfam13667 645127005117 ThiC family; Region: ThiC; pfam01964 645127005118 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 645127005119 thiamine phosphate binding site [chemical binding]; other site 645127005120 active site 645127005121 pyrophosphate binding site [ion binding]; other site 645127005122 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 645127005123 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645127005124 Walker A/P-loop; other site 645127005125 ATP binding site [chemical binding]; other site 645127005126 Q-loop/lid; other site 645127005127 ABC transporter signature motif; other site 645127005128 Walker B; other site 645127005129 D-loop; other site 645127005130 H-loop/switch region; other site 645127005131 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 645127005132 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 645127005133 active site 645127005134 catalytic site [active] 645127005135 thiamine biosynthesis protein ThiF; Validated; Region: PRK05600 645127005136 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 645127005137 ATP binding site [chemical binding]; other site 645127005138 substrate interface [chemical binding]; other site 645127005139 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 645127005140 active site residue [active] 645127005141 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 645127005142 ThiS interaction site; other site 645127005143 putative active site [active] 645127005144 tetramer interface [polypeptide binding]; other site 645127005145 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 645127005146 thiS-thiF/thiG interaction site; other site 645127005147 hydroxyglutarate oxidase; Provisional; Region: PRK11728 645127005148 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 645127005149 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 645127005150 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 645127005151 NAD(P) binding site [chemical binding]; other site 645127005152 active site 645127005153 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 645127005154 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 645127005155 ATP-grasp domain; Region: ATP-grasp; pfam02222 645127005156 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645127005157 ABC transporter signature motif; other site 645127005158 Walker B; other site 645127005159 D-loop; other site 645127005160 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645127005161 Walker A/P-loop; other site 645127005162 ATP binding site [chemical binding]; other site 645127005163 ABC transporter signature motif; other site 645127005164 Walker B; other site 645127005165 D-loop; other site 645127005166 H-loop/switch region; other site 645127005167 Cobalt transport protein; Region: CbiQ; cl00463 645127005168 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645127005169 Walker A/P-loop; other site 645127005170 ATP binding site [chemical binding]; other site 645127005171 Q-loop/lid; other site 645127005172 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 645127005173 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645127005174 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 645127005175 Walker A/P-loop; other site 645127005176 ATP binding site [chemical binding]; other site 645127005177 Q-loop/lid; other site 645127005178 ABC transporter signature motif; other site 645127005179 Walker B; other site 645127005180 D-loop; other site 645127005181 H-loop/switch region; other site 645127005182 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 645127005183 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 645127005184 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 645127005185 substrate binding site [chemical binding]; other site 645127005186 THF binding site; other site 645127005187 zinc-binding site [ion binding]; other site 645127005188 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 645127005189 active site 645127005190 Uncharacterized conserved protein [Function unknown]; Region: COG1359 645127005191 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 645127005192 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 645127005193 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 645127005194 E3 interaction surface; other site 645127005195 lipoyl attachment site [posttranslational modification]; other site 645127005196 e3 binding domain; Region: E3_binding; pfam02817 645127005197 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 645127005198 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 645127005199 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 645127005200 alpha subunit interface [polypeptide binding]; other site 645127005201 TPP binding site [chemical binding]; other site 645127005202 heterodimer interface [polypeptide binding]; other site 645127005203 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 645127005204 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 645127005205 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 645127005206 tetramer interface [polypeptide binding]; other site 645127005207 TPP-binding site [chemical binding]; other site 645127005208 heterodimer interface [polypeptide binding]; other site 645127005209 phosphorylation loop region [posttranslational modification] 645127005210 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 645127005211 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 645127005212 GDP-binding site [chemical binding]; other site 645127005213 ACT binding site; other site 645127005214 IMP binding site; other site 645127005215 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 645127005216 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 645127005217 ring oligomerisation interface [polypeptide binding]; other site 645127005218 ATP/Mg binding site [chemical binding]; other site 645127005219 stacking interactions; other site 645127005220 hinge regions; other site 645127005221 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 645127005222 oligomerisation interface [polypeptide binding]; other site 645127005223 mobile loop; other site 645127005224 roof hairpin; other site 645127005225 UGMP family protein; Validated; Region: PRK09604 645127005226 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645127005227 Coenzyme A binding pocket [chemical binding]; other site 645127005228 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 645127005229 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 645127005230 Glycoprotease family; Region: Peptidase_M22; pfam00814 645127005231 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 645127005232 alanine racemase; Reviewed; Region: alr; PRK00053 645127005233 active site 645127005234 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 645127005235 dimer interface [polypeptide binding]; other site 645127005236 substrate binding site [chemical binding]; other site 645127005237 catalytic residues [active] 645127005238 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 645127005239 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 645127005240 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 645127005241 putative substrate binding site [chemical binding]; other site 645127005242 putative ATP binding site [chemical binding]; other site 645127005243 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 645127005244 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 645127005245 glutaminase active site [active] 645127005246 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 645127005247 dimer interface [polypeptide binding]; other site 645127005248 active site 645127005249 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 645127005250 dimer interface [polypeptide binding]; other site 645127005251 active site 645127005252 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 645127005253 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 645127005254 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 645127005255 active site 645127005256 substrate binding site [chemical binding]; other site 645127005257 metal binding site [ion binding]; metal-binding site 645127005258 Acyltransferase family; Region: Acyl_transf_3; pfam01757 645127005259 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 645127005260 active site 645127005261 catalytic triad [active] 645127005262 oxyanion hole [active] 645127005263 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 645127005264 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 645127005265 23S rRNA interface [nucleotide binding]; other site 645127005266 L3 interface [polypeptide binding]; other site 645127005267 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 645127005268 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645127005269 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645127005270 homodimer interface [polypeptide binding]; other site 645127005271 catalytic residue [active] 645127005272 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 645127005273 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 645127005274 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 645127005275 substrate binding pocket [chemical binding]; other site 645127005276 membrane-bound complex binding site; other site 645127005277 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 645127005278 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 645127005279 substrate binding pocket [chemical binding]; other site 645127005280 membrane-bound complex binding site; other site 645127005281 hinge residues; other site 645127005282 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 645127005283 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 645127005284 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 645127005285 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 645127005286 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 645127005287 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 645127005288 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 645127005289 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 645127005290 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 645127005291 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 645127005292 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 645127005293 active site 645127005294 catalytic residues [active] 645127005295 Protein of unknown function (DUF690); Region: DUF690; cl04939 645127005296 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 645127005297 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 645127005298 Walker A/P-loop; other site 645127005299 ATP binding site [chemical binding]; other site 645127005300 Q-loop/lid; other site 645127005301 ABC transporter signature motif; other site 645127005302 Walker B; other site 645127005303 D-loop; other site 645127005304 H-loop/switch region; other site 645127005305 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 645127005306 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 645127005307 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 645127005308 dimerization interface 3.5A [polypeptide binding]; other site 645127005309 active site 645127005310 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 645127005311 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 645127005312 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 645127005313 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 645127005314 alphaNTD - beta interaction site [polypeptide binding]; other site 645127005315 alphaNTD homodimer interface [polypeptide binding]; other site 645127005316 alphaNTD - beta' interaction site [polypeptide binding]; other site 645127005317 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 645127005318 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 645127005319 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 645127005320 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 645127005321 RNA binding surface [nucleotide binding]; other site 645127005322 30S ribosomal protein S11; Validated; Region: PRK05309 645127005323 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 645127005324 30S ribosomal protein S13; Region: bact_S13; TIGR03631 645127005325 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 645127005326 rRNA binding site [nucleotide binding]; other site 645127005327 predicted 30S ribosome binding site; other site 645127005328 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 645127005329 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 645127005330 active site turn [active] 645127005331 phosphorylation site [posttranslational modification] 645127005332 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 645127005333 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 645127005334 HPr interaction site; other site 645127005335 glycerol kinase (GK) interaction site [polypeptide binding]; other site 645127005336 active site 645127005337 phosphorylation site [posttranslational modification] 645127005338 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 645127005339 beta-galactosidase; Region: BGL; TIGR03356 645127005340 transcriptional antiterminator BglG; Provisional; Region: PRK09772 645127005341 CAT RNA binding domain; Region: CAT_RBD; smart01061 645127005342 PRD domain; Region: PRD; pfam00874 645127005343 PRD domain; Region: PRD; pfam00874 645127005344 maltose O-acetyltransferase; Provisional; Region: PRK10092 645127005345 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 645127005346 active site 645127005347 substrate binding site [chemical binding]; other site 645127005348 trimer interface [polypeptide binding]; other site 645127005349 CoA binding site [chemical binding]; other site 645127005350 arginine deiminase; Provisional; Region: PRK01388 645127005351 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 645127005352 active site 645127005353 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 645127005354 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 645127005355 Walker A/P-loop; other site 645127005356 ATP binding site [chemical binding]; other site 645127005357 Q-loop/lid; other site 645127005358 ABC transporter signature motif; other site 645127005359 Walker B; other site 645127005360 D-loop; other site 645127005361 H-loop/switch region; other site 645127005362 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 645127005363 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 645127005364 ABC-ATPase subunit interface; other site 645127005365 dimer interface [polypeptide binding]; other site 645127005366 putative PBP binding regions; other site 645127005367 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 645127005368 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 645127005369 intersubunit interface [polypeptide binding]; other site 645127005370 adenylate kinase; Reviewed; Region: adk; PRK00279 645127005371 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 645127005372 AMP-binding site [chemical binding]; other site 645127005373 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 645127005374 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 645127005375 SecY translocase; Region: SecY; pfam00344 645127005376 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 645127005377 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 645127005378 23S rRNA binding site [nucleotide binding]; other site 645127005379 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 645127005380 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 645127005381 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 645127005382 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 645127005383 5S rRNA interface [nucleotide binding]; other site 645127005384 L27 interface [polypeptide binding]; other site 645127005385 23S rRNA interface [nucleotide binding]; other site 645127005386 L5 interface [polypeptide binding]; other site 645127005387 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 645127005388 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 645127005389 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 645127005390 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 645127005391 Cupin domain; Region: Cupin_2; cl17218 645127005392 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 645127005393 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 645127005394 intersubunit interface [polypeptide binding]; other site 645127005395 PhoD-like phosphatase; Region: PhoD; pfam09423 645127005396 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 645127005397 putative active site [active] 645127005398 putative metal binding site [ion binding]; other site 645127005399 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 645127005400 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 645127005401 active site 645127005402 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 645127005403 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 645127005404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645127005405 putative substrate translocation pore; other site 645127005406 Capsule biosynthesis CapC; Region: Caps_synth_CapC; pfam14102 645127005407 Capsule biosynthesis CapC; Region: Caps_synth_CapC; cl14855 645127005408 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 645127005409 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 645127005410 active site 645127005411 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 645127005412 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 645127005413 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 645127005414 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 645127005415 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 645127005416 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 645127005417 RNA binding site [nucleotide binding]; other site 645127005418 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 645127005419 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 645127005420 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 645127005421 FAD binding pocket [chemical binding]; other site 645127005422 FAD binding motif [chemical binding]; other site 645127005423 phosphate binding motif [ion binding]; other site 645127005424 NAD binding pocket [chemical binding]; other site 645127005425 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 645127005426 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 645127005427 intersubunit interface [polypeptide binding]; other site 645127005428 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 645127005429 Isochorismatase family; Region: Isochorismatase; pfam00857 645127005430 catalytic triad [active] 645127005431 conserved cis-peptide bond; other site 645127005432 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 645127005433 Lipase (class 2); Region: Lipase_2; pfam01674 645127005434 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 645127005435 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 645127005436 acyl-activating enzyme (AAE) consensus motif; other site 645127005437 active site 645127005438 AMP binding site [chemical binding]; other site 645127005439 substrate binding site [chemical binding]; other site 645127005440 Condensation domain; Region: Condensation; pfam00668 645127005441 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 645127005442 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 645127005443 acyl-activating enzyme (AAE) consensus motif; other site 645127005444 AMP binding site [chemical binding]; other site 645127005445 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 645127005446 Condensation domain; Region: Condensation; pfam00668 645127005447 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 645127005448 Phosphopantetheine attachment site; Region: PP-binding; cl09936 645127005449 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 645127005450 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 645127005451 NAD(P) binding site [chemical binding]; other site 645127005452 active site 645127005453 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 645127005454 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 645127005455 acyl-activating enzyme (AAE) consensus motif; other site 645127005456 active site 645127005457 AMP binding site [chemical binding]; other site 645127005458 CoA binding site [chemical binding]; other site 645127005459 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 645127005460 CoA binding site [chemical binding]; other site 645127005461 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 645127005462 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 645127005463 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 645127005464 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 645127005465 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 645127005466 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645127005467 Walker A/P-loop; other site 645127005468 ATP binding site [chemical binding]; other site 645127005469 Q-loop/lid; other site 645127005470 ABC transporter signature motif; other site 645127005471 Walker B; other site 645127005472 D-loop; other site 645127005473 H-loop/switch region; other site 645127005474 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 645127005475 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 645127005476 AP (apurinic/apyrimidinic) site pocket; other site 645127005477 DNA interaction; other site 645127005478 Metal-binding active site; metal-binding site 645127005479 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 645127005480 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 645127005481 putative translocon interaction site; other site 645127005482 23S rRNA interface [nucleotide binding]; other site 645127005483 signal recognition particle (SRP54) interaction site; other site 645127005484 L23 interface [polypeptide binding]; other site 645127005485 trigger factor interaction site; other site 645127005486 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 645127005487 23S rRNA interface [nucleotide binding]; other site 645127005488 5S rRNA interface [nucleotide binding]; other site 645127005489 putative antibiotic binding site [chemical binding]; other site 645127005490 L25 interface [polypeptide binding]; other site 645127005491 L27 interface [polypeptide binding]; other site 645127005492 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 645127005493 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 645127005494 G-X-X-G motif; other site 645127005495 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 645127005496 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 645127005497 putative translocon binding site; other site 645127005498 protein-rRNA interface [nucleotide binding]; other site 645127005499 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 645127005500 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 645127005501 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 645127005502 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 645127005503 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 645127005504 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 645127005505 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 645127005506 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 645127005507 Asp23 family; Region: Asp23; pfam03780 645127005508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645127005509 S-adenosylmethionine binding site [chemical binding]; other site 645127005510 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 645127005511 elongation factor Tu; Reviewed; Region: PRK00049 645127005512 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 645127005513 G1 box; other site 645127005514 GEF interaction site [polypeptide binding]; other site 645127005515 GTP/Mg2+ binding site [chemical binding]; other site 645127005516 Switch I region; other site 645127005517 G2 box; other site 645127005518 G3 box; other site 645127005519 Switch II region; other site 645127005520 G4 box; other site 645127005521 G5 box; other site 645127005522 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 645127005523 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 645127005524 Antibiotic Binding Site [chemical binding]; other site 645127005525 elongation factor G; Reviewed; Region: PRK00007 645127005526 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 645127005527 G1 box; other site 645127005528 putative GEF interaction site [polypeptide binding]; other site 645127005529 GTP/Mg2+ binding site [chemical binding]; other site 645127005530 Switch I region; other site 645127005531 G2 box; other site 645127005532 G3 box; other site 645127005533 Switch II region; other site 645127005534 G4 box; other site 645127005535 G5 box; other site 645127005536 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 645127005537 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 645127005538 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 645127005539 30S ribosomal protein S7; Validated; Region: PRK05302 645127005540 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 645127005541 16S rRNA interaction site [nucleotide binding]; other site 645127005542 streptomycin interaction site [chemical binding]; other site 645127005543 23S rRNA interaction site [nucleotide binding]; other site 645127005544 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 645127005545 TM2 domain; Region: TM2; pfam05154 645127005546 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 645127005547 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 645127005548 substrate binding site [chemical binding]; other site 645127005549 dimer interface [polypeptide binding]; other site 645127005550 ATP binding site [chemical binding]; other site 645127005551 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 645127005552 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 645127005553 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 645127005554 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 645127005555 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 645127005556 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 645127005557 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 645127005558 G-loop; other site 645127005559 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 645127005560 DNA binding site [nucleotide binding] 645127005561 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 645127005562 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 645127005563 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 645127005564 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 645127005565 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 645127005566 RPB1 interaction site [polypeptide binding]; other site 645127005567 RPB10 interaction site [polypeptide binding]; other site 645127005568 RPB11 interaction site [polypeptide binding]; other site 645127005569 RPB3 interaction site [polypeptide binding]; other site 645127005570 RPB12 interaction site [polypeptide binding]; other site 645127005571 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 645127005572 peripheral dimer interface [polypeptide binding]; other site 645127005573 core dimer interface [polypeptide binding]; other site 645127005574 L10 interface [polypeptide binding]; other site 645127005575 L11 interface [polypeptide binding]; other site 645127005576 putative EF-Tu interaction site [polypeptide binding]; other site 645127005577 putative EF-G interaction site [polypeptide binding]; other site 645127005578 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 645127005579 23S rRNA interface [nucleotide binding]; other site 645127005580 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 645127005581 Transcriptional regulators [Transcription]; Region: FadR; COG2186 645127005582 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645127005583 DNA-binding site [nucleotide binding]; DNA binding site 645127005584 FCD domain; Region: FCD; pfam07729 645127005585 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 645127005586 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 645127005587 putative active site cavity [active] 645127005588 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 645127005589 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 645127005590 nucleotide binding site [chemical binding]; other site 645127005591 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 645127005592 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 645127005593 active site 645127005594 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 645127005595 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 645127005596 active site 645127005597 trimer interface [polypeptide binding]; other site 645127005598 allosteric site; other site 645127005599 active site lid [active] 645127005600 hexamer (dimer of trimers) interface [polypeptide binding]; other site 645127005601 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 645127005602 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 645127005603 inhibitor site; inhibition site 645127005604 active site 645127005605 dimer interface [polypeptide binding]; other site 645127005606 catalytic residue [active] 645127005607 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 645127005608 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 645127005609 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 645127005610 catalytic site [active] 645127005611 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 645127005612 Asp-box motif; other site 645127005613 Asp-box motif; other site 645127005614 catalytic site [active] 645127005615 putative sialic acid transporter; Provisional; Region: PRK03893 645127005616 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645127005617 putative substrate translocation pore; other site 645127005618 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 645127005619 Na binding site [ion binding]; other site 645127005620 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 645127005621 mRNA/rRNA interface [nucleotide binding]; other site 645127005622 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 645127005623 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 645127005624 23S rRNA interface [nucleotide binding]; other site 645127005625 L7/L12 interface [polypeptide binding]; other site 645127005626 putative thiostrepton binding site; other site 645127005627 L25 interface [polypeptide binding]; other site 645127005628 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 645127005629 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 645127005630 putative homodimer interface [polypeptide binding]; other site 645127005631 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 645127005632 heterodimer interface [polypeptide binding]; other site 645127005633 homodimer interface [polypeptide binding]; other site 645127005634 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 645127005635 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 645127005636 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 645127005637 substrate binding pocket [chemical binding]; other site 645127005638 chain length determination region; other site 645127005639 substrate-Mg2+ binding site; other site 645127005640 catalytic residues [active] 645127005641 aspartate-rich region 1; other site 645127005642 active site lid residues [active] 645127005643 aspartate-rich region 2; other site 645127005644 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 645127005645 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645127005646 S-adenosylmethionine binding site [chemical binding]; other site 645127005647 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 645127005648 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 645127005649 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 645127005650 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 645127005651 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 645127005652 PYR/PP interface [polypeptide binding]; other site 645127005653 dimer interface [polypeptide binding]; other site 645127005654 TPP binding site [chemical binding]; other site 645127005655 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 645127005656 TPP-binding site; other site 645127005657 O-succinylbenzoate synthase; Provisional; Region: PRK02901 645127005658 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 645127005659 active site 645127005660 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 645127005661 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 645127005662 substrate binding site [chemical binding]; other site 645127005663 oxyanion hole (OAH) forming residues; other site 645127005664 trimer interface [polypeptide binding]; other site 645127005665 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 645127005666 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 645127005667 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 645127005668 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 645127005669 acyl-activating enzyme (AAE) consensus motif; other site 645127005670 AMP binding site [chemical binding]; other site 645127005671 active site 645127005672 CoA binding site [chemical binding]; other site 645127005673 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 645127005674 UbiA prenyltransferase family; Region: UbiA; pfam01040 645127005675 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 645127005676 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 645127005677 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 645127005678 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 645127005679 NAD binding site [chemical binding]; other site 645127005680 substrate binding site [chemical binding]; other site 645127005681 homodimer interface [polypeptide binding]; other site 645127005682 active site 645127005683 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 645127005684 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 645127005685 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 645127005686 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 645127005687 ResB-like family; Region: ResB; pfam05140 645127005688 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 645127005689 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 645127005690 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 645127005691 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 645127005692 catalytic residues [active] 645127005693 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 645127005694 catalytic core [active] 645127005695 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 645127005696 RNA/DNA hybrid binding site [nucleotide binding]; other site 645127005697 active site 645127005698 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 645127005699 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 645127005700 inhibitor-cofactor binding pocket; inhibition site 645127005701 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645127005702 catalytic residue [active] 645127005703 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 645127005704 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 645127005705 Endomembrane protein 70; Region: EMP70; pfam02990 645127005706 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 645127005707 dimer interface [polypeptide binding]; other site 645127005708 active site 645127005709 Schiff base residues; other site 645127005710 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 645127005711 active site 645127005712 homodimer interface [polypeptide binding]; other site 645127005713 SAM binding site [chemical binding]; other site 645127005714 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 645127005715 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 645127005716 active site 645127005717 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 645127005718 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 645127005719 domain interfaces; other site 645127005720 active site 645127005721 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 645127005722 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 645127005723 tRNA; other site 645127005724 putative tRNA binding site [nucleotide binding]; other site 645127005725 putative NADP binding site [chemical binding]; other site 645127005726 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 645127005727 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 645127005728 DNA binding domain, excisionase family; Region: excise; TIGR01764 645127005729 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 645127005730 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 645127005731 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 645127005732 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 645127005733 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 645127005734 Predicted membrane protein [Function unknown]; Region: COG4270 645127005735 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645127005736 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645127005737 active site 645127005738 phosphorylation site [posttranslational modification] 645127005739 intermolecular recognition site; other site 645127005740 dimerization interface [polypeptide binding]; other site 645127005741 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645127005742 DNA binding site [nucleotide binding] 645127005743 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 645127005744 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645127005745 dimer interface [polypeptide binding]; other site 645127005746 phosphorylation site [posttranslational modification] 645127005747 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645127005748 ATP binding site [chemical binding]; other site 645127005749 Mg2+ binding site [ion binding]; other site 645127005750 G-X-G motif; other site 645127005751 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 645127005752 catalytic core [active] 645127005753 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 645127005754 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 645127005755 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 645127005756 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 645127005757 putative ADP-binding pocket [chemical binding]; other site 645127005758 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 645127005759 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 645127005760 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 645127005761 acyl-activating enzyme (AAE) consensus motif; other site 645127005762 AMP binding site [chemical binding]; other site 645127005763 active site 645127005764 CoA binding site [chemical binding]; other site 645127005765 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 645127005766 FAD binding domain; Region: FAD_binding_4; pfam01565 645127005767 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 645127005768 Methyltransferase domain; Region: Methyltransf_23; pfam13489 645127005769 Abortive infection C-terminus; Region: Abi_C; pfam14355 645127005770 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 645127005771 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 645127005772 Multicopper oxidase; Region: Cu-oxidase; pfam00394 645127005773 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 645127005774 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645127005775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645127005776 active site 645127005777 phosphorylation site [posttranslational modification] 645127005778 intermolecular recognition site; other site 645127005779 dimerization interface [polypeptide binding]; other site 645127005780 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645127005781 DNA binding site [nucleotide binding] 645127005782 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 645127005783 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645127005784 dimerization interface [polypeptide binding]; other site 645127005785 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645127005786 dimer interface [polypeptide binding]; other site 645127005787 phosphorylation site [posttranslational modification] 645127005788 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645127005789 ATP binding site [chemical binding]; other site 645127005790 Mg2+ binding site [ion binding]; other site 645127005791 G-X-G motif; other site 645127005792 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 645127005793 metal-binding site [ion binding] 645127005794 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 645127005795 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 645127005796 Soluble P-type ATPase [General function prediction only]; Region: COG4087 645127005797 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 645127005798 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 645127005799 Predicted membrane protein [Function unknown]; Region: COG2733 645127005800 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 645127005801 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 645127005802 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 645127005803 L-aspartate oxidase; Provisional; Region: PRK06175 645127005804 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 645127005805 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 645127005806 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 645127005807 putative Iron-sulfur protein interface [polypeptide binding]; other site 645127005808 proximal heme binding site [chemical binding]; other site 645127005809 distal heme binding site [chemical binding]; other site 645127005810 putative dimer interface [polypeptide binding]; other site 645127005811 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 645127005812 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 645127005813 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 645127005814 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 645127005815 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 645127005816 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645127005817 motif II; other site 645127005818 malate synthase G; Provisional; Region: PRK02999 645127005819 active site 645127005820 isocitrate lyase; Provisional; Region: PRK15063 645127005821 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 645127005822 tetramer interface [polypeptide binding]; other site 645127005823 active site 645127005824 Mg2+/Mn2+ binding site [ion binding]; other site 645127005825 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 645127005826 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645127005827 non-specific DNA binding site [nucleotide binding]; other site 645127005828 salt bridge; other site 645127005829 sequence-specific DNA binding site [nucleotide binding]; other site 645127005830 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 645127005831 Domain of unknown function (DUF955); Region: DUF955; pfam06114 645127005832 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 645127005833 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 645127005834 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 645127005835 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 645127005836 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 645127005837 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 645127005838 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 645127005839 substrate binding pocket [chemical binding]; other site 645127005840 catalytic triad [active] 645127005841 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 645127005842 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 645127005843 substrate binding pocket [chemical binding]; other site 645127005844 catalytic triad [active] 645127005845 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 645127005846 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 645127005847 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 645127005848 ABC-ATPase subunit interface; other site 645127005849 dimer interface [polypeptide binding]; other site 645127005850 putative PBP binding regions; other site 645127005851 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 645127005852 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 645127005853 Walker A/P-loop; other site 645127005854 ATP binding site [chemical binding]; other site 645127005855 Q-loop/lid; other site 645127005856 ABC transporter signature motif; other site 645127005857 Walker B; other site 645127005858 D-loop; other site 645127005859 H-loop/switch region; other site 645127005860 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 645127005861 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 645127005862 putative ligand binding residues [chemical binding]; other site 645127005863 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 645127005864 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 645127005865 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 645127005866 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 645127005867 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 645127005868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645127005869 short chain dehydrogenase; Validated; Region: PRK06182 645127005870 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 645127005871 NADP binding site [chemical binding]; other site 645127005872 active site 645127005873 steroid binding site; other site 645127005874 DNA polymerase III subunit delta'; Validated; Region: PRK07940 645127005875 DNA polymerase III subunit delta'; Validated; Region: PRK08485 645127005876 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 645127005877 dimerization interface [polypeptide binding]; other site 645127005878 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 645127005879 cyclase homology domain; Region: CHD; cd07302 645127005880 nucleotidyl binding site; other site 645127005881 metal binding site [ion binding]; metal-binding site 645127005882 dimer interface [polypeptide binding]; other site 645127005883 acyl-CoA synthetase; Validated; Region: PRK07788 645127005884 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 645127005885 acyl-activating enzyme (AAE) consensus motif; other site 645127005886 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 645127005887 AMP binding site [chemical binding]; other site 645127005888 active site 645127005889 acyl-activating enzyme (AAE) consensus motif; other site 645127005890 CoA binding site [chemical binding]; other site 645127005891 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 645127005892 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 645127005893 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 645127005894 acyl-CoA synthetase; Validated; Region: PRK07788 645127005895 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 645127005896 acyl-activating enzyme (AAE) consensus motif; other site 645127005897 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 645127005898 AMP binding site [chemical binding]; other site 645127005899 active site 645127005900 acyl-activating enzyme (AAE) consensus motif; other site 645127005901 CoA binding site [chemical binding]; other site 645127005902 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 645127005903 active site 645127005904 catalytic triad [active] 645127005905 oxyanion hole [active] 645127005906 myosin-cross-reactive antigen; Provisional; Region: PRK13977 645127005907 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 645127005908 active site 645127005909 oxyanion hole [active] 645127005910 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 645127005911 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 645127005912 putative NAD(P) binding site [chemical binding]; other site 645127005913 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 645127005914 beta-galactosidase; Region: BGL; TIGR03356 645127005915 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 645127005916 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 645127005917 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 645127005918 active site 645127005919 interdomain interaction site; other site 645127005920 putative metal-binding site [ion binding]; other site 645127005921 nucleotide binding site [chemical binding]; other site 645127005922 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 645127005923 domain I; other site 645127005924 phosphate binding site [ion binding]; other site 645127005925 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 645127005926 domain II; other site 645127005927 domain III; other site 645127005928 nucleotide binding site [chemical binding]; other site 645127005929 DNA binding groove [nucleotide binding] 645127005930 catalytic site [active] 645127005931 domain IV; other site 645127005932 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 645127005933 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 645127005934 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 645127005935 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 645127005936 DNA-binding site [nucleotide binding]; DNA binding site 645127005937 RNA-binding motif; other site 645127005938 TAP-like protein; Region: Abhydrolase_4; pfam08386 645127005939 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 645127005940 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 645127005941 ATP binding site [chemical binding]; other site 645127005942 putative Mg++ binding site [ion binding]; other site 645127005943 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645127005944 nucleotide binding region [chemical binding]; other site 645127005945 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 645127005946 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 645127005947 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 645127005948 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 645127005949 Type II/IV secretion system protein; Region: T2SE; pfam00437 645127005950 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 645127005951 ATP binding site [chemical binding]; other site 645127005952 Walker A motif; other site 645127005953 hexamer interface [polypeptide binding]; other site 645127005954 Walker B motif; other site 645127005955 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 645127005956 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 645127005957 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 645127005958 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 645127005959 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 645127005960 putative active site [active] 645127005961 putative CoA binding site [chemical binding]; other site 645127005962 nudix motif; other site 645127005963 metal binding site [ion binding]; metal-binding site 645127005964 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 645127005965 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 645127005966 catalytic residues [active] 645127005967 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 645127005968 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 645127005969 minor groove reading motif; other site 645127005970 helix-hairpin-helix signature motif; other site 645127005971 substrate binding pocket [chemical binding]; other site 645127005972 active site 645127005973 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 645127005974 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 645127005975 ligand binding site [chemical binding]; other site 645127005976 flexible hinge region; other site 645127005977 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 645127005978 putative switch regulator; other site 645127005979 non-specific DNA interactions [nucleotide binding]; other site 645127005980 DNA binding site [nucleotide binding] 645127005981 sequence specific DNA binding site [nucleotide binding]; other site 645127005982 putative cAMP binding site [chemical binding]; other site 645127005983 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 645127005984 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 645127005985 homotrimer interaction site [polypeptide binding]; other site 645127005986 putative active site [active] 645127005987 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 645127005988 Transcription factor WhiB; Region: Whib; pfam02467 645127005989 Transglycosylase; Region: Transgly; pfam00912 645127005990 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 645127005991 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 645127005992 Yqey-like protein; Region: YqeY; cl17540 645127005993 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 645127005994 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 645127005995 putative active site [active] 645127005996 putative metal binding site [ion binding]; other site 645127005997 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 645127005998 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 645127005999 active site 2 [active] 645127006000 active site 1 [active] 645127006001 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 645127006002 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 645127006003 active site 645127006004 catalytic tetrad [active] 645127006005 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 645127006006 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 645127006007 Cl- selectivity filter; other site 645127006008 Cl- binding residues [ion binding]; other site 645127006009 pore gating glutamate residue; other site 645127006010 dimer interface [polypeptide binding]; other site 645127006011 H+/Cl- coupling transport residue; other site 645127006012 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 645127006013 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 645127006014 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 645127006015 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 645127006016 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 645127006017 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 645127006018 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 645127006019 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 645127006020 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654 645127006021 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612 645127006022 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 645127006023 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 645127006024 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 645127006025 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 645127006026 NAD(P) binding site [chemical binding]; other site 645127006027 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 645127006028 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 645127006029 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 645127006030 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 645127006031 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 645127006032 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 645127006033 Walker A/P-loop; other site 645127006034 ATP binding site [chemical binding]; other site 645127006035 Q-loop/lid; other site 645127006036 ABC transporter signature motif; other site 645127006037 Walker B; other site 645127006038 D-loop; other site 645127006039 H-loop/switch region; other site 645127006040 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 645127006041 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 645127006042 active site 645127006043 Iron permease FTR1 family; Region: FTR1; cl00475 645127006044 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 645127006045 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 645127006046 Imelysin; Region: Peptidase_M75; pfam09375 645127006047 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 645127006048 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 645127006049 putative homodimer interface [polypeptide binding]; other site 645127006050 putative homotetramer interface [polypeptide binding]; other site 645127006051 putative allosteric switch controlling residues; other site 645127006052 putative metal binding site [ion binding]; other site 645127006053 putative homodimer-homodimer interface [polypeptide binding]; other site 645127006054 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 645127006055 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 645127006056 metal-binding site [ion binding] 645127006057 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 645127006058 Soluble P-type ATPase [General function prediction only]; Region: COG4087 645127006059 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 645127006060 metal-binding site [ion binding] 645127006061 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 645127006062 hydrophobic ligand binding site; other site 645127006063 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 645127006064 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 645127006065 NAD(P) binding site [chemical binding]; other site 645127006066 active site 645127006067 Predicted membrane protein [Function unknown]; Region: COG2246 645127006068 GtrA-like protein; Region: GtrA; pfam04138 645127006069 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 645127006070 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 645127006071 NADH(P)-binding; Region: NAD_binding_10; pfam13460 645127006072 NAD(P) binding site [chemical binding]; other site 645127006073 active site 645127006074 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 645127006075 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 645127006076 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 645127006077 conserved cys residue [active] 645127006078 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 645127006079 FAD binding domain; Region: FAD_binding_4; pfam01565 645127006080 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 645127006081 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 645127006082 classical (c) SDRs; Region: SDR_c; cd05233 645127006083 NAD(P) binding site [chemical binding]; other site 645127006084 active site 645127006085 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 645127006086 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 645127006087 dimer interface [polypeptide binding]; other site 645127006088 PYR/PP interface [polypeptide binding]; other site 645127006089 TPP binding site [chemical binding]; other site 645127006090 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 645127006091 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 645127006092 TPP-binding site [chemical binding]; other site 645127006093 dimer interface [polypeptide binding]; other site 645127006094 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 645127006095 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 645127006096 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 645127006097 catalytic residues [active] 645127006098 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 645127006099 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645127006100 Walker A/P-loop; other site 645127006101 ATP binding site [chemical binding]; other site 645127006102 Q-loop/lid; other site 645127006103 ABC transporter signature motif; other site 645127006104 Walker B; other site 645127006105 D-loop; other site 645127006106 H-loop/switch region; other site 645127006107 CrcB-like protein; Region: CRCB; cl09114 645127006108 CrcB-like protein; Region: CRCB; pfam02537 645127006109 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 645127006110 replicative DNA helicase; Provisional; Region: PRK05636 645127006111 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 645127006112 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 645127006113 Walker A motif; other site 645127006114 ATP binding site [chemical binding]; other site 645127006115 Walker B motif; other site 645127006116 DNA binding loops [nucleotide binding] 645127006117 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 645127006118 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 645127006119 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 645127006120 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 645127006121 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 645127006122 dimer interface [polypeptide binding]; other site 645127006123 ssDNA binding site [nucleotide binding]; other site 645127006124 tetramer (dimer of dimers) interface [polypeptide binding]; other site 645127006125 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 645127006126 Predicted integral membrane protein [Function unknown]; Region: COG5650 645127006127 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 645127006128 Transglycosylase; Region: Transgly; pfam00912 645127006129 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 645127006130 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 645127006131 MarR family; Region: MarR; pfam01047 645127006132 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 645127006133 Ligand Binding Site [chemical binding]; other site 645127006134 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 645127006135 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 645127006136 Catalytic site [active] 645127006137 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 645127006138 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 645127006139 active site 645127006140 HIGH motif; other site 645127006141 nucleotide binding site [chemical binding]; other site 645127006142 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 645127006143 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 645127006144 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 645127006145 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 645127006146 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 645127006147 active site 645127006148 KMSKS motif; other site 645127006149 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 645127006150 tRNA binding surface [nucleotide binding]; other site 645127006151 short chain dehydrogenase; Provisional; Region: PRK08219 645127006152 classical (c) SDRs; Region: SDR_c; cd05233 645127006153 NAD(P) binding site [chemical binding]; other site 645127006154 active site 645127006155 SdpI/YhfL protein family; Region: SdpI; pfam13630 645127006156 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 645127006157 nudix motif; other site 645127006158 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 645127006159 Predicted membrane protein [Function unknown]; Region: COG1511 645127006160 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 645127006161 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645127006162 Walker A/P-loop; other site 645127006163 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 645127006164 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 645127006165 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 645127006166 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 645127006167 hypothetical protein; Validated; Region: PRK00228 645127006168 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 645127006169 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 645127006170 active site 645127006171 NTP binding site [chemical binding]; other site 645127006172 metal binding triad [ion binding]; metal-binding site 645127006173 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 645127006174 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 645127006175 Zn2+ binding site [ion binding]; other site 645127006176 Mg2+ binding site [ion binding]; other site 645127006177 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 645127006178 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 645127006179 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 645127006180 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 645127006181 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 645127006182 DNA binding residues [nucleotide binding] 645127006183 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 645127006184 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 645127006185 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 645127006186 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 645127006187 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 645127006188 catalytic residues [active] 645127006189 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 645127006190 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 645127006191 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 645127006192 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 645127006193 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 645127006194 active site 645127006195 metal binding site [ion binding]; metal-binding site 645127006196 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 645127006197 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 645127006198 ParB-like nuclease domain; Region: ParBc; pfam02195 645127006199 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 645127006200 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 645127006201 P-loop; other site 645127006202 Magnesium ion binding site [ion binding]; other site 645127006203 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 645127006204 Magnesium ion binding site [ion binding]; other site 645127006205 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 645127006206 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645127006207 S-adenosylmethionine binding site [chemical binding]; other site 645127006208 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 645127006209 G-X-X-G motif; other site 645127006210 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 645127006211 RxxxH motif; other site 645127006212 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 645127006213 Ribonuclease P; Region: Ribonuclease_P; cl00457 645127006214 Ribosomal protein L34; Region: Ribosomal_L34; cl00370