-- dump date 20140619_051958 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1224163000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 1224163000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1224163000003 Walker A motif; other site 1224163000004 ATP binding site [chemical binding]; other site 1224163000005 Walker B motif; other site 1224163000006 arginine finger; other site 1224163000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1224163000008 DnaA box-binding interface [nucleotide binding]; other site 1224163000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1224163000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1224163000011 putative DNA binding surface [nucleotide binding]; other site 1224163000012 dimer interface [polypeptide binding]; other site 1224163000013 beta-clamp/clamp loader binding surface; other site 1224163000014 beta-clamp/translesion DNA polymerase binding surface; other site 1224163000015 recombination protein F; Reviewed; Region: recF; PRK00064 1224163000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1224163000017 Walker A/P-loop; other site 1224163000018 ATP binding site [chemical binding]; other site 1224163000019 Q-loop/lid; other site 1224163000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1224163000021 ABC transporter signature motif; other site 1224163000022 Walker B; other site 1224163000023 D-loop; other site 1224163000024 H-loop/switch region; other site 1224163000025 Protein of unknown function (DUF721); Region: DUF721; cl02324 1224163000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1224163000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1224163000028 ATP binding site [chemical binding]; other site 1224163000029 Mg2+ binding site [ion binding]; other site 1224163000030 G-X-G motif; other site 1224163000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1224163000032 anchoring element; other site 1224163000033 dimer interface [polypeptide binding]; other site 1224163000034 ATP binding site [chemical binding]; other site 1224163000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1224163000036 active site 1224163000037 putative metal-binding site [ion binding]; other site 1224163000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1224163000039 DNA gyrase subunit A; Validated; Region: PRK05560 1224163000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1224163000041 CAP-like domain; other site 1224163000042 active site 1224163000043 primary dimer interface [polypeptide binding]; other site 1224163000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1224163000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1224163000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1224163000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1224163000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1224163000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1224163000050 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1224163000051 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1224163000052 active site 1224163000053 catalytic triad [active] 1224163000054 oxyanion hole [active] 1224163000055 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 1224163000056 CHY zinc finger; Region: zf-CHY; pfam05495 1224163000057 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1224163000058 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1224163000059 active site 1224163000060 ATP-binding site [chemical binding]; other site 1224163000061 pantoate-binding site; other site 1224163000062 HXXH motif; other site 1224163000063 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1224163000064 oligomerization interface [polypeptide binding]; other site 1224163000065 active site 1224163000066 metal binding site [ion binding]; metal-binding site 1224163000067 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1224163000068 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1224163000069 Walker A/P-loop; other site 1224163000070 ATP binding site [chemical binding]; other site 1224163000071 Q-loop/lid; other site 1224163000072 ABC transporter signature motif; other site 1224163000073 Walker B; other site 1224163000074 D-loop; other site 1224163000075 H-loop/switch region; other site 1224163000076 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 1224163000077 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1224163000078 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1224163000079 shikimate binding site; other site 1224163000080 NAD(P) binding site [chemical binding]; other site 1224163000081 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1224163000082 active site 1224163000083 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1224163000084 putative septation inhibitor protein; Reviewed; Region: PRK00159 1224163000085 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1224163000086 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1224163000087 active site 1224163000088 ATP binding site [chemical binding]; other site 1224163000089 substrate binding site [chemical binding]; other site 1224163000090 activation loop (A-loop); other site 1224163000091 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1224163000092 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1224163000093 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1224163000094 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1224163000095 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1224163000096 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1224163000097 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1224163000098 active site 1224163000099 ATP binding site [chemical binding]; other site 1224163000100 substrate binding site [chemical binding]; other site 1224163000101 activation loop (A-loop); other site 1224163000102 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1224163000103 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1224163000104 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1224163000105 Protein phosphatase 2C; Region: PP2C; pfam00481 1224163000106 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1224163000107 active site 1224163000108 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1224163000109 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1224163000110 phosphopeptide binding site; other site 1224163000111 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1224163000112 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1224163000113 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1224163000114 phosphopeptide binding site; other site 1224163000115 phenol 2-monooxygenase; Provisional; Region: PRK08294 1224163000116 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979 1224163000117 dimer interface [polypeptide binding]; other site 1224163000118 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1224163000119 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1224163000120 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1224163000121 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1224163000122 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1224163000123 CGNR zinc finger; Region: zf-CGNR; pfam11706 1224163000124 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1224163000125 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1224163000126 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1224163000127 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1224163000128 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 1224163000129 Active site serine [active] 1224163000130 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1224163000131 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1224163000132 Predicted membrane protein [Function unknown]; Region: COG4129 1224163000133 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1224163000134 Fasciclin domain; Region: Fasciclin; pfam02469 1224163000135 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1224163000136 Predicted flavoprotein [General function prediction only]; Region: COG0431 1224163000137 Ferritin-like domain; Region: Ferritin; pfam00210 1224163000138 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1224163000139 ferroxidase diiron center [ion binding]; other site 1224163000140 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1224163000141 Peptidase family M23; Region: Peptidase_M23; pfam01551 1224163000142 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1224163000143 Cation efflux family; Region: Cation_efflux; pfam01545 1224163000144 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1224163000145 substrate binding pocket [chemical binding]; other site 1224163000146 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1224163000147 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1224163000148 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1224163000149 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1224163000150 Transcription factor WhiB; Region: Whib; pfam02467 1224163000151 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1224163000152 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1224163000153 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1224163000154 AsnC family; Region: AsnC_trans_reg; pfam01037 1224163000155 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1224163000156 tetramerization interface [polypeptide binding]; other site 1224163000157 active site 1224163000158 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1224163000159 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1224163000160 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163000161 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1224163000162 putative substrate translocation pore; other site 1224163000163 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1224163000164 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1224163000165 Walker A/P-loop; other site 1224163000166 ATP binding site [chemical binding]; other site 1224163000167 Q-loop/lid; other site 1224163000168 ABC transporter signature motif; other site 1224163000169 Walker B; other site 1224163000170 D-loop; other site 1224163000171 H-loop/switch region; other site 1224163000172 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1224163000173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1224163000174 dimer interface [polypeptide binding]; other site 1224163000175 conserved gate region; other site 1224163000176 putative PBP binding loops; other site 1224163000177 ABC-ATPase subunit interface; other site 1224163000178 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1224163000179 NMT1-like family; Region: NMT1_2; pfam13379 1224163000180 OsmC-like protein; Region: OsmC; pfam02566 1224163000181 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1224163000182 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1224163000183 active site 1224163000184 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1224163000185 metal binding site [ion binding]; metal-binding site 1224163000186 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1224163000187 dimer interface [polypeptide binding]; other site 1224163000188 conserved gate region; other site 1224163000189 ABC-ATPase subunit interface; other site 1224163000190 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1224163000191 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1224163000192 Walker A/P-loop; other site 1224163000193 ATP binding site [chemical binding]; other site 1224163000194 Q-loop/lid; other site 1224163000195 ABC transporter signature motif; other site 1224163000196 Walker B; other site 1224163000197 D-loop; other site 1224163000198 H-loop/switch region; other site 1224163000199 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1224163000200 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1224163000201 DinB superfamily; Region: DinB_2; pfam12867 1224163000202 putative monooxygenase; Provisional; Region: PRK11118 1224163000203 GXWXG protein; Region: GXWXG; pfam14231 1224163000204 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 1224163000205 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1224163000206 Coenzyme A transferase; Region: CoA_trans; cl17247 1224163000207 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1224163000208 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1224163000209 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1224163000210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163000211 metabolite-proton symporter; Region: 2A0106; TIGR00883 1224163000212 putative substrate translocation pore; other site 1224163000213 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 1224163000214 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1224163000215 dimer interface [polypeptide binding]; other site 1224163000216 active site 1224163000217 Muconolactone delta-isomerase; Region: MIase; cl01992 1224163000218 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1224163000219 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1224163000220 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1224163000221 dimerization interface [polypeptide binding]; other site 1224163000222 substrate binding pocket [chemical binding]; other site 1224163000223 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 1224163000224 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 1224163000225 NAD(P) binding site [chemical binding]; other site 1224163000226 catalytic residues [active] 1224163000227 short chain dehydrogenase; Provisional; Region: PRK08267 1224163000228 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1224163000229 NAD(P) binding site [chemical binding]; other site 1224163000230 active site 1224163000231 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1224163000232 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 1224163000233 active site 1224163000234 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1224163000235 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 1224163000236 active site 1224163000237 dimer interface [polypeptide binding]; other site 1224163000238 metal binding site [ion binding]; metal-binding site 1224163000239 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1224163000240 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1224163000241 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1224163000242 active site 1224163000243 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1224163000244 putative active site [active] 1224163000245 putative catalytic site [active] 1224163000246 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1224163000247 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1224163000248 DNA-binding site [nucleotide binding]; DNA binding site 1224163000249 FCD domain; Region: FCD; pfam07729 1224163000250 Fic family protein [Function unknown]; Region: COG3177 1224163000251 Fic/DOC family; Region: Fic; pfam02661 1224163000252 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1224163000253 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1224163000254 NAD(P) binding site [chemical binding]; other site 1224163000255 catalytic residues [active] 1224163000256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1224163000257 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1224163000258 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1224163000259 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1224163000260 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1224163000261 catalytic residue [active] 1224163000262 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 1224163000263 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1224163000264 dimer interface [polypeptide binding]; other site 1224163000265 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1224163000266 catalytic residue [active] 1224163000267 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1224163000268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163000269 putative substrate translocation pore; other site 1224163000270 POT family; Region: PTR2; cl17359 1224163000271 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1224163000272 classical (c) SDRs; Region: SDR_c; cd05233 1224163000273 NAD(P) binding site [chemical binding]; other site 1224163000274 active site 1224163000275 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1224163000276 Beta-lactamase; Region: Beta-lactamase; pfam00144 1224163000277 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1224163000278 Cytochrome P450; Region: p450; cl12078 1224163000279 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1224163000280 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1224163000281 FMN-binding pocket [chemical binding]; other site 1224163000282 flavin binding motif; other site 1224163000283 phosphate binding motif [ion binding]; other site 1224163000284 beta-alpha-beta structure motif; other site 1224163000285 NAD binding pocket [chemical binding]; other site 1224163000286 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1224163000287 catalytic loop [active] 1224163000288 iron binding site [ion binding]; other site 1224163000289 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1224163000290 Cytochrome P450; Region: p450; cl12078 1224163000291 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1224163000292 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1224163000293 FMN-binding pocket [chemical binding]; other site 1224163000294 flavin binding motif; other site 1224163000295 phosphate binding motif [ion binding]; other site 1224163000296 beta-alpha-beta structure motif; other site 1224163000297 NAD binding pocket [chemical binding]; other site 1224163000298 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1224163000299 catalytic loop [active] 1224163000300 iron binding site [ion binding]; other site 1224163000301 Strictosidine synthase; Region: Str_synth; pfam03088 1224163000302 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1224163000303 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1224163000304 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1224163000305 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1224163000306 intersubunit interface [polypeptide binding]; other site 1224163000307 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1224163000308 ABC-ATPase subunit interface; other site 1224163000309 dimer interface [polypeptide binding]; other site 1224163000310 putative PBP binding regions; other site 1224163000311 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1224163000312 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1224163000313 Walker A/P-loop; other site 1224163000314 ATP binding site [chemical binding]; other site 1224163000315 Q-loop/lid; other site 1224163000316 ABC transporter signature motif; other site 1224163000317 Walker B; other site 1224163000318 D-loop; other site 1224163000319 H-loop/switch region; other site 1224163000320 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1224163000321 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 1224163000322 NAD binding site [chemical binding]; other site 1224163000323 substrate binding site [chemical binding]; other site 1224163000324 catalytic Zn binding site [ion binding]; other site 1224163000325 structural Zn binding site [ion binding]; other site 1224163000326 NAD-dependent deacetylase; Provisional; Region: PRK05333 1224163000327 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1224163000328 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1224163000329 Cytochrome P450; Region: p450; cl12078 1224163000330 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1224163000331 metal-binding site [ion binding] 1224163000332 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1224163000333 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1224163000334 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1224163000335 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1224163000336 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1224163000337 Lipase (class 2); Region: Lipase_2; pfam01674 1224163000338 AMP nucleosidase; Provisional; Region: PRK08292 1224163000339 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1224163000340 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1224163000341 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1224163000342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163000343 putative substrate translocation pore; other site 1224163000344 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1224163000345 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1224163000346 AMIN domain; Region: AMIN; pfam11741 1224163000347 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 1224163000348 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1224163000349 inhibitor-cofactor binding pocket; inhibition site 1224163000350 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1224163000351 catalytic residue [active] 1224163000352 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1224163000353 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1224163000354 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1224163000355 active site 1224163000356 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1224163000357 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1224163000358 NAD(P) binding site [chemical binding]; other site 1224163000359 catalytic residues [active] 1224163000360 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 1224163000361 Nitrate and nitrite sensing; Region: NIT; pfam08376 1224163000362 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 1224163000363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 1224163000364 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 1224163000365 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1224163000366 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1224163000367 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 1224163000368 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1224163000369 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 1224163000370 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1224163000371 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1224163000372 Ligand Binding Site [chemical binding]; other site 1224163000373 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1224163000374 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1224163000375 Ligand binding site [chemical binding]; other site 1224163000376 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1224163000377 benzoate transport; Region: 2A0115; TIGR00895 1224163000378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163000379 putative substrate translocation pore; other site 1224163000380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163000381 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1224163000382 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1224163000383 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1224163000384 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1224163000385 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1224163000386 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1224163000387 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1224163000388 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1224163000389 carboxyltransferase (CT) interaction site; other site 1224163000390 biotinylation site [posttranslational modification]; other site 1224163000391 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1224163000392 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1224163000393 active site 1224163000394 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1224163000395 putative active site [active] 1224163000396 putative catalytic site [active] 1224163000397 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1224163000398 AMP-binding domain protein; Validated; Region: PRK08315 1224163000399 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1224163000400 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1224163000401 acyl-activating enzyme (AAE) consensus motif; other site 1224163000402 acyl-activating enzyme (AAE) consensus motif; other site 1224163000403 putative AMP binding site [chemical binding]; other site 1224163000404 putative active site [active] 1224163000405 putative CoA binding site [chemical binding]; other site 1224163000406 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1224163000407 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1224163000408 putative acyltransferase; Provisional; Region: PRK05790 1224163000409 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1224163000410 dimer interface [polypeptide binding]; other site 1224163000411 active site 1224163000412 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1224163000413 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1224163000414 MULE transposase domain; Region: MULE; pfam10551 1224163000415 DDE superfamily endonuclease; Region: DDE_5; cl17874 1224163000416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 1224163000417 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 1224163000418 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 1224163000419 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1224163000420 dimer interface [polypeptide binding]; other site 1224163000421 FMN binding site [chemical binding]; other site 1224163000422 NADPH bind site [chemical binding]; other site 1224163000423 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1224163000424 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1224163000425 non-specific DNA binding site [nucleotide binding]; other site 1224163000426 salt bridge; other site 1224163000427 sequence-specific DNA binding site [nucleotide binding]; other site 1224163000428 Cupin domain; Region: Cupin_2; pfam07883 1224163000429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1224163000430 S-adenosylmethionine binding site [chemical binding]; other site 1224163000431 non-LTR RNase HI domain of reverse transcriptases; Region: Rnase_HI_RT_non_LTR; cd09276 1224163000432 RNA/DNA hybrid binding site [nucleotide binding]; other site 1224163000433 active site 1224163000434 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1224163000435 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1224163000436 active site 1224163000437 Uncharacterized conserved protein [Function unknown]; Region: COG4850 1224163000438 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 1224163000439 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1224163000440 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1224163000441 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1224163000442 substrate binding site [chemical binding]; other site 1224163000443 THF binding site; other site 1224163000444 zinc-binding site [ion binding]; other site 1224163000445 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1224163000446 FAD binding site [chemical binding]; other site 1224163000447 Predicted acetyltransferase [General function prediction only]; Region: COG3153 1224163000448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1224163000449 S-adenosylmethionine binding site [chemical binding]; other site 1224163000450 Fic family protein [Function unknown]; Region: COG3177 1224163000451 Fic/DOC family; Region: Fic; pfam02661 1224163000452 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1224163000453 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1224163000454 NAD(P) binding site [chemical binding]; other site 1224163000455 active site 1224163000456 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1224163000457 active site 1224163000458 DNA binding site [nucleotide binding] 1224163000459 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1224163000460 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1224163000461 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1224163000462 active site 1224163000463 non-prolyl cis peptide bond; other site 1224163000464 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1224163000465 putative DNA binding site [nucleotide binding]; other site 1224163000466 putative Zn2+ binding site [ion binding]; other site 1224163000467 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1224163000468 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1224163000469 nucleotide binding site [chemical binding]; other site 1224163000470 H+ Antiporter protein; Region: 2A0121; TIGR00900 1224163000471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163000472 putative substrate translocation pore; other site 1224163000473 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1224163000474 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1224163000475 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1224163000476 NAD(P) binding site [chemical binding]; other site 1224163000477 putative active site [active] 1224163000478 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1224163000479 DNA-binding site [nucleotide binding]; DNA binding site 1224163000480 RNA-binding motif; other site 1224163000481 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1224163000482 putative active site [active] 1224163000483 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1224163000484 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1224163000485 NAD-dependent deacetylase; Provisional; Region: PRK00481 1224163000486 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1224163000487 NAD+ binding site [chemical binding]; other site 1224163000488 substrate binding site [chemical binding]; other site 1224163000489 Zn binding site [ion binding]; other site 1224163000490 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805 1224163000491 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1224163000492 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1224163000493 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1224163000494 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1224163000495 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1224163000496 catalytic residue [active] 1224163000497 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 1224163000498 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1224163000499 ATP binding site [chemical binding]; other site 1224163000500 putative Mg++ binding site [ion binding]; other site 1224163000501 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1224163000502 nucleotide binding region [chemical binding]; other site 1224163000503 ATP-binding site [chemical binding]; other site 1224163000504 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 1224163000505 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1224163000506 maltose O-acetyltransferase; Provisional; Region: PRK10092 1224163000507 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1224163000508 active site 1224163000509 substrate binding site [chemical binding]; other site 1224163000510 trimer interface [polypeptide binding]; other site 1224163000511 CoA binding site [chemical binding]; other site 1224163000512 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 1224163000513 S4 domain; Region: S4_2; pfam13275 1224163000514 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1224163000515 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1224163000516 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1224163000517 DNA binding site [nucleotide binding] 1224163000518 active site 1224163000519 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1224163000520 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1224163000521 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1224163000522 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1224163000523 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1224163000524 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1224163000525 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1224163000526 NAD binding site [chemical binding]; other site 1224163000527 catalytic Zn binding site [ion binding]; other site 1224163000528 structural Zn binding site [ion binding]; other site 1224163000529 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1224163000530 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1224163000531 putative NAD(P) binding site [chemical binding]; other site 1224163000532 putative substrate binding site [chemical binding]; other site 1224163000533 catalytic Zn binding site [ion binding]; other site 1224163000534 structural Zn binding site [ion binding]; other site 1224163000535 dimer interface [polypeptide binding]; other site 1224163000536 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1224163000537 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1224163000538 glycogen branching enzyme; Provisional; Region: PRK14705 1224163000539 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1224163000540 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1224163000541 DNA-binding site [nucleotide binding]; DNA binding site 1224163000542 UTRA domain; Region: UTRA; pfam07702 1224163000543 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 1224163000544 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1224163000545 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1224163000546 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1224163000547 substrate binding pocket [chemical binding]; other site 1224163000548 membrane-bound complex binding site; other site 1224163000549 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1224163000550 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1224163000551 Walker A/P-loop; other site 1224163000552 ATP binding site [chemical binding]; other site 1224163000553 Q-loop/lid; other site 1224163000554 ABC transporter signature motif; other site 1224163000555 Walker B; other site 1224163000556 D-loop; other site 1224163000557 H-loop/switch region; other site 1224163000558 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1224163000559 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1224163000560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1224163000561 dimer interface [polypeptide binding]; other site 1224163000562 conserved gate region; other site 1224163000563 putative PBP binding loops; other site 1224163000564 ABC-ATPase subunit interface; other site 1224163000565 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 1224163000566 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1224163000567 motif II; other site 1224163000568 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 1224163000569 catalytic Zn binding site [ion binding]; other site 1224163000570 putative phosphonate catabolism associated alcohol dehydrogenase; Region: HpnZ_proposed; TIGR03366 1224163000571 structural Zn binding site [ion binding]; other site 1224163000572 tetramer interface [polypeptide binding]; other site 1224163000573 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1224163000574 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1224163000575 active site 1224163000576 Zn binding site [ion binding]; other site 1224163000577 Protease prsW family; Region: PrsW-protease; pfam13367 1224163000578 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 1224163000579 putative FMN binding site [chemical binding]; other site 1224163000580 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 1224163000581 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 1224163000582 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1224163000583 CoenzymeA binding site [chemical binding]; other site 1224163000584 subunit interaction site [polypeptide binding]; other site 1224163000585 PHB binding site; other site 1224163000586 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1224163000587 CoenzymeA binding site [chemical binding]; other site 1224163000588 subunit interaction site [polypeptide binding]; other site 1224163000589 PHB binding site; other site 1224163000590 Protein of unknown function (DUF3792); Region: DUF3792; cl14821 1224163000591 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1224163000592 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1224163000593 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1224163000594 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 1224163000595 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 1224163000596 short chain dehydrogenase; Provisional; Region: PRK08251 1224163000597 classical (c) SDRs; Region: SDR_c; cd05233 1224163000598 NAD(P) binding site [chemical binding]; other site 1224163000599 active site 1224163000600 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1224163000601 FAD binding domain; Region: FAD_binding_4; pfam01565 1224163000602 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1224163000603 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1224163000604 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1224163000605 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1224163000606 PhoU domain; Region: PhoU; pfam01895 1224163000607 PhoU domain; Region: PhoU; pfam01895 1224163000608 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 1224163000609 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1224163000610 S-adenosylmethionine binding site [chemical binding]; other site 1224163000611 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1224163000612 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1224163000613 glutaminase; Provisional; Region: PRK00971 1224163000614 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1224163000615 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 1224163000616 GtrA-like protein; Region: GtrA; pfam04138 1224163000617 Predicted membrane protein [Function unknown]; Region: COG2246 1224163000618 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1224163000619 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1224163000620 Coenzyme A binding pocket [chemical binding]; other site 1224163000621 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1224163000622 active site 1224163000623 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1224163000624 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1224163000625 active site 1224163000626 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1224163000627 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1224163000628 Walker A/P-loop; other site 1224163000629 ATP binding site [chemical binding]; other site 1224163000630 Q-loop/lid; other site 1224163000631 ABC transporter signature motif; other site 1224163000632 Walker B; other site 1224163000633 D-loop; other site 1224163000634 H-loop/switch region; other site 1224163000635 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1224163000636 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1224163000637 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1224163000638 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1224163000639 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1224163000640 catalytic residue [active] 1224163000641 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1224163000642 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1224163000643 NAD(P) binding site [chemical binding]; other site 1224163000644 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1224163000645 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 1224163000646 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1224163000647 PLD-like domain; Region: PLDc_2; pfam13091 1224163000648 putative active site [active] 1224163000649 catalytic site [active] 1224163000650 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1224163000651 PLD-like domain; Region: PLDc_2; pfam13091 1224163000652 putative active site [active] 1224163000653 catalytic site [active] 1224163000654 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1224163000655 nucleoside/Zn binding site; other site 1224163000656 dimer interface [polypeptide binding]; other site 1224163000657 catalytic motif [active] 1224163000658 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK05597 1224163000659 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1224163000660 ATP binding site [chemical binding]; other site 1224163000661 substrate interface [chemical binding]; other site 1224163000662 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1224163000663 active site residue [active] 1224163000664 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1224163000665 MoaE homodimer interface [polypeptide binding]; other site 1224163000666 MoaD interaction [polypeptide binding]; other site 1224163000667 active site residues [active] 1224163000668 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1224163000669 MPT binding site; other site 1224163000670 trimer interface [polypeptide binding]; other site 1224163000671 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1224163000672 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1224163000673 dimer interface [polypeptide binding]; other site 1224163000674 putative functional site; other site 1224163000675 putative MPT binding site; other site 1224163000676 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1224163000677 MoaE interaction surface [polypeptide binding]; other site 1224163000678 MoeB interaction surface [polypeptide binding]; other site 1224163000679 thiocarboxylated glycine; other site 1224163000680 Predicted membrane protein [Function unknown]; Region: COG1950 1224163000681 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1224163000682 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1224163000683 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1224163000684 homodimer interface [polypeptide binding]; other site 1224163000685 catalytic residue [active] 1224163000686 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1224163000687 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1224163000688 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1224163000689 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1224163000690 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1224163000691 transmembrane helices; other site 1224163000692 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1224163000693 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1224163000694 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1224163000695 Divalent cation transporter; Region: MgtE; cl00786 1224163000696 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 1224163000697 prephenate dehydrogenase; Validated; Region: PRK08507 1224163000698 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1224163000699 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1224163000700 nucleoside/Zn binding site; other site 1224163000701 dimer interface [polypeptide binding]; other site 1224163000702 catalytic motif [active] 1224163000703 CsbD-like; Region: CsbD; cl17424 1224163000704 MMPL family; Region: MMPL; pfam03176 1224163000705 MMPL family; Region: MMPL; pfam03176 1224163000706 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1224163000707 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1224163000708 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1224163000709 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1224163000710 active site 1224163000711 HIGH motif; other site 1224163000712 nucleotide binding site [chemical binding]; other site 1224163000713 active site 1224163000714 KMSKS motif; other site 1224163000715 Predicted membrane protein [Function unknown]; Region: COG2323 1224163000716 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 1224163000717 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1224163000718 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1224163000719 heme binding pocket [chemical binding]; other site 1224163000720 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1224163000721 domain interactions; other site 1224163000722 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1224163000723 nudix motif; other site 1224163000724 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1224163000725 quinolinate synthetase; Provisional; Region: PRK09375 1224163000726 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543 1224163000727 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1224163000728 dimerization interface [polypeptide binding]; other site 1224163000729 active site 1224163000730 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1224163000731 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1224163000732 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1224163000733 catalytic residue [active] 1224163000734 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1224163000735 Cytochrome P450; Region: p450; cl12078 1224163000736 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1224163000737 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1224163000738 FMN-binding pocket [chemical binding]; other site 1224163000739 flavin binding motif; other site 1224163000740 phosphate binding motif [ion binding]; other site 1224163000741 beta-alpha-beta structure motif; other site 1224163000742 NAD binding pocket [chemical binding]; other site 1224163000743 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1224163000744 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1224163000745 catalytic loop [active] 1224163000746 iron binding site [ion binding]; other site 1224163000747 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1224163000748 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1224163000749 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1224163000750 homodimer interface [polypeptide binding]; other site 1224163000751 catalytic residue [active] 1224163000752 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1224163000753 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1224163000754 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1224163000755 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1224163000756 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1224163000757 Walker A motif; other site 1224163000758 ATP binding site [chemical binding]; other site 1224163000759 Walker B motif; other site 1224163000760 hypothetical protein; Validated; Region: PRK00153 1224163000761 recombination protein RecR; Reviewed; Region: recR; PRK00076 1224163000762 RecR protein; Region: RecR; pfam02132 1224163000763 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1224163000764 putative active site [active] 1224163000765 putative metal-binding site [ion binding]; other site 1224163000766 tetramer interface [polypeptide binding]; other site 1224163000767 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1224163000768 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1224163000769 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1224163000770 NAD(P) binding pocket [chemical binding]; other site 1224163000771 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1224163000772 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1224163000773 trimer interface [polypeptide binding]; other site 1224163000774 putative metal binding site [ion binding]; other site 1224163000775 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1224163000776 catalytic triad [active] 1224163000777 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1224163000778 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1224163000779 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1224163000780 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 1224163000781 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1224163000782 active site 1224163000783 substrate binding site [chemical binding]; other site 1224163000784 Domain of unknown function (DUF2020); Region: DUF2020; pfam09449 1224163000785 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 1224163000786 active site 1224163000787 catalytic site [active] 1224163000788 2-isopropylmalate synthase; Validated; Region: PRK03739 1224163000789 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1224163000790 active site 1224163000791 catalytic residues [active] 1224163000792 metal binding site [ion binding]; metal-binding site 1224163000793 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1224163000794 aspartate kinase; Reviewed; Region: PRK06635 1224163000795 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1224163000796 putative nucleotide binding site [chemical binding]; other site 1224163000797 putative catalytic residues [active] 1224163000798 putative Mg ion binding site [ion binding]; other site 1224163000799 putative aspartate binding site [chemical binding]; other site 1224163000800 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1224163000801 putative allosteric regulatory site; other site 1224163000802 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1224163000803 putative allosteric regulatory residue; other site 1224163000804 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1224163000805 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1224163000806 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1224163000807 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 1224163000808 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1224163000809 Cation efflux family; Region: Cation_efflux; cl00316 1224163000810 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1224163000811 RNA polymerase sigma factor; Provisional; Region: PRK12535 1224163000812 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1224163000813 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1224163000814 DNA binding residues [nucleotide binding] 1224163000815 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1224163000816 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1224163000817 heme binding pocket [chemical binding]; other site 1224163000818 OsmC-like protein; Region: OsmC; cl00767 1224163000819 Predicted membrane protein [Function unknown]; Region: COG1511 1224163000820 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 1224163000821 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1224163000822 active site 1224163000823 metal binding site [ion binding]; metal-binding site 1224163000824 Yqey-like protein; Region: YqeY; pfam09424 1224163000825 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1224163000826 Transglycosylase; Region: Transgly; pfam00912 1224163000827 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1224163000828 Transcription factor WhiB; Region: Whib; pfam02467 1224163000829 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1224163000830 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1224163000831 homotrimer interaction site [polypeptide binding]; other site 1224163000832 putative active site [active] 1224163000833 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1224163000834 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1224163000835 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1224163000836 ligand binding site [chemical binding]; other site 1224163000837 flexible hinge region; other site 1224163000838 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1224163000839 putative switch regulator; other site 1224163000840 non-specific DNA interactions [nucleotide binding]; other site 1224163000841 DNA binding site [nucleotide binding] 1224163000842 sequence specific DNA binding site [nucleotide binding]; other site 1224163000843 putative cAMP binding site [chemical binding]; other site 1224163000844 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1224163000845 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1224163000846 minor groove reading motif; other site 1224163000847 helix-hairpin-helix signature motif; other site 1224163000848 substrate binding pocket [chemical binding]; other site 1224163000849 active site 1224163000850 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1224163000851 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1224163000852 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1224163000853 catalytic residues [active] 1224163000854 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1224163000855 putative active site [active] 1224163000856 putative CoA binding site [chemical binding]; other site 1224163000857 nudix motif; other site 1224163000858 metal binding site [ion binding]; metal-binding site 1224163000859 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1224163000860 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1224163000861 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1224163000862 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1224163000863 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1224163000864 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1224163000865 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1224163000866 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1224163000867 motif II; other site 1224163000868 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1224163000869 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1224163000870 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1224163000871 ATP binding site [chemical binding]; other site 1224163000872 Walker A motif; other site 1224163000873 hexamer interface [polypeptide binding]; other site 1224163000874 Walker B motif; other site 1224163000875 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1224163000876 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 1224163000877 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1224163000878 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1224163000879 ATP binding site [chemical binding]; other site 1224163000880 putative Mg++ binding site [ion binding]; other site 1224163000881 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1224163000882 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1224163000883 DNA-binding site [nucleotide binding]; DNA binding site 1224163000884 RNA-binding motif; other site 1224163000885 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1224163000886 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1224163000887 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1224163000888 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1224163000889 active site 1224163000890 metal binding site [ion binding]; metal-binding site 1224163000891 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1224163000892 domain I; other site 1224163000893 phosphate binding site [ion binding]; other site 1224163000894 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1224163000895 domain II; other site 1224163000896 domain III; other site 1224163000897 nucleotide binding site [chemical binding]; other site 1224163000898 DNA binding groove [nucleotide binding] 1224163000899 catalytic site [active] 1224163000900 domain IV; other site 1224163000901 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1224163000902 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1224163000903 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1224163000904 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1224163000905 active site residue [active] 1224163000906 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1224163000907 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1224163000908 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1224163000909 Predicted membrane protein [Function unknown]; Region: COG2364 1224163000910 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1224163000911 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1224163000912 dimerization interface [polypeptide binding]; other site 1224163000913 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1224163000914 cyclase homology domain; Region: CHD; cd07302 1224163000915 nucleotidyl binding site; other site 1224163000916 metal binding site [ion binding]; metal-binding site 1224163000917 dimer interface [polypeptide binding]; other site 1224163000918 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1224163000919 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1224163000920 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1224163000921 DNA binding residues [nucleotide binding] 1224163000922 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1224163000923 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1224163000924 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1224163000925 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1224163000926 Predicted membrane protein [Function unknown]; Region: COG2323 1224163000927 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1224163000928 acyl-CoA synthetase; Validated; Region: PRK07788 1224163000929 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1224163000930 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1224163000931 acyl-activating enzyme (AAE) consensus motif; other site 1224163000932 acyl-activating enzyme (AAE) consensus motif; other site 1224163000933 AMP binding site [chemical binding]; other site 1224163000934 active site 1224163000935 CoA binding site [chemical binding]; other site 1224163000936 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1224163000937 active site 1224163000938 catalytic triad [active] 1224163000939 oxyanion hole [active] 1224163000940 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1224163000941 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1224163000942 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1224163000943 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1224163000944 active site 1224163000945 catalytic triad [active] 1224163000946 oxyanion hole [active] 1224163000947 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 1224163000948 homodimer interface [polypeptide binding]; other site 1224163000949 chemical substrate binding site [chemical binding]; other site 1224163000950 oligomer interface [polypeptide binding]; other site 1224163000951 metal binding site [ion binding]; metal-binding site 1224163000952 GIY-YIG domain of uncharacterized bacterial protein structurally related to COG3410; Region: GIY-YIG_COG3410; cd10439 1224163000953 GIY-YIG motif/motif A; other site 1224163000954 putative active site [active] 1224163000955 putative metal binding site [ion binding]; other site 1224163000956 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 1224163000957 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1224163000958 ATP binding site [chemical binding]; other site 1224163000959 putative Mg++ binding site [ion binding]; other site 1224163000960 Uncharacterized conserved protein [Function unknown]; Region: COG3410 1224163000961 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1224163000962 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1224163000963 NAD binding site [chemical binding]; other site 1224163000964 catalytic Zn binding site [ion binding]; other site 1224163000965 substrate binding site [chemical binding]; other site 1224163000966 structural Zn binding site [ion binding]; other site 1224163000967 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1224163000968 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1224163000969 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 1224163000970 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1224163000971 Walker A/P-loop; other site 1224163000972 ATP binding site [chemical binding]; other site 1224163000973 Q-loop/lid; other site 1224163000974 ABC transporter signature motif; other site 1224163000975 Walker B; other site 1224163000976 D-loop; other site 1224163000977 H-loop/switch region; other site 1224163000978 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1224163000979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1224163000980 dimer interface [polypeptide binding]; other site 1224163000981 conserved gate region; other site 1224163000982 ABC-ATPase subunit interface; other site 1224163000983 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 1224163000984 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 1224163000985 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1224163000986 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1224163000987 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1224163000988 putative active site [active] 1224163000989 putative substrate binding site [chemical binding]; other site 1224163000990 putative cosubstrate binding site; other site 1224163000991 catalytic site [active] 1224163000992 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1224163000993 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1224163000994 NAD(P) binding site [chemical binding]; other site 1224163000995 active site 1224163000996 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1224163000997 Thioredoxin; Region: Thioredoxin_4; pfam13462 1224163000998 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 1224163000999 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1224163001000 Ligand binding site; other site 1224163001001 Putative Catalytic site; other site 1224163001002 DXD motif; other site 1224163001003 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1224163001004 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1224163001005 active site 1224163001006 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1224163001007 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1224163001008 substrate binding site; other site 1224163001009 tetramer interface; other site 1224163001010 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1224163001011 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 1224163001012 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1224163001013 NADP binding site [chemical binding]; other site 1224163001014 active site 1224163001015 putative substrate binding site [chemical binding]; other site 1224163001016 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1224163001017 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1224163001018 NAD binding site [chemical binding]; other site 1224163001019 substrate binding site [chemical binding]; other site 1224163001020 homodimer interface [polypeptide binding]; other site 1224163001021 active site 1224163001022 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1224163001023 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1224163001024 active site 1224163001025 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1224163001026 Zn binding site [ion binding]; other site 1224163001027 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1224163001028 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1224163001029 Putative esterase; Region: Esterase; pfam00756 1224163001030 Putative esterase; Region: Esterase; pfam00756 1224163001031 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1224163001032 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1224163001033 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1224163001034 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1224163001035 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1224163001036 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 1224163001037 putative Iron-sulfur protein interface [polypeptide binding]; other site 1224163001038 proximal heme binding site [chemical binding]; other site 1224163001039 distal heme binding site [chemical binding]; other site 1224163001040 putative dimer interface [polypeptide binding]; other site 1224163001041 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 1224163001042 L-aspartate oxidase; Provisional; Region: PRK06175 1224163001043 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1224163001044 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 1224163001045 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1224163001046 Predicted membrane protein [Function unknown]; Region: COG2733 1224163001047 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1224163001048 Class I aldolases; Region: Aldolase_Class_I; cl17187 1224163001049 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1224163001050 Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]; Region: AceE; COG2609 1224163001051 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1224163001052 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1224163001053 FAD binding domain; Region: FAD_binding_4; pfam01565 1224163001054 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1224163001055 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1224163001056 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1224163001057 DNA binding site [nucleotide binding] 1224163001058 domain linker motif; other site 1224163001059 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1224163001060 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1224163001061 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1224163001062 Walker A/P-loop; other site 1224163001063 ATP binding site [chemical binding]; other site 1224163001064 Q-loop/lid; other site 1224163001065 ABC transporter signature motif; other site 1224163001066 Walker B; other site 1224163001067 D-loop; other site 1224163001068 H-loop/switch region; other site 1224163001069 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1224163001070 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1224163001071 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1224163001072 TM-ABC transporter signature motif; other site 1224163001073 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1224163001074 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1224163001075 ligand binding site [chemical binding]; other site 1224163001076 dimerization interface [polypeptide binding]; other site 1224163001077 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1224163001078 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1224163001079 substrate binding site [chemical binding]; other site 1224163001080 dimer interface [polypeptide binding]; other site 1224163001081 ATP binding site [chemical binding]; other site 1224163001082 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 1224163001083 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1224163001084 Protein of unknown function DUF262; Region: DUF262; pfam03235 1224163001085 Uncharacterized conserved protein [Function unknown]; Region: COG3472 1224163001086 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 1224163001087 Domain of unknown function (DUF3806); Region: DUF3806; pfam12713 1224163001088 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 1224163001089 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1224163001090 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1224163001091 dimerization interface [polypeptide binding]; other site 1224163001092 substrate binding pocket [chemical binding]; other site 1224163001093 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1224163001094 dimerization interface [polypeptide binding]; other site 1224163001095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163001096 putative substrate translocation pore; other site 1224163001097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163001098 FOG: CBS domain [General function prediction only]; Region: COG0517 1224163001099 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1224163001100 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 1224163001101 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1224163001102 dimer interface [polypeptide binding]; other site 1224163001103 active site 1224163001104 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1224163001105 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1224163001106 Walker A motif; other site 1224163001107 ATP binding site [chemical binding]; other site 1224163001108 Walker B motif; other site 1224163001109 arginine finger; other site 1224163001110 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1224163001111 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 1224163001112 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1224163001113 ATP binding site [chemical binding]; other site 1224163001114 putative Mg++ binding site [ion binding]; other site 1224163001115 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1224163001116 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1224163001117 nucleotide binding region [chemical binding]; other site 1224163001118 ATP-binding site [chemical binding]; other site 1224163001119 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1224163001120 HTH-like domain; Region: HTH_21; pfam13276 1224163001121 Integrase core domain; Region: rve; pfam00665 1224163001122 Integrase core domain; Region: rve_3; cl15866 1224163001123 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1224163001124 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1224163001125 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1224163001126 phosphate binding site [ion binding]; other site 1224163001127 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1224163001128 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1224163001129 active site 2 [active] 1224163001130 active site 1 [active] 1224163001131 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1224163001132 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1224163001133 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1224163001134 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1224163001135 putative NAD(P) binding site [chemical binding]; other site 1224163001136 active site 1224163001137 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1224163001138 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1224163001139 active site 1224163001140 Predicted membrane protein [Function unknown]; Region: COG2323 1224163001141 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 1224163001142 RDD family; Region: RDD; pfam06271 1224163001143 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1224163001144 putative homotetramer interface [polypeptide binding]; other site 1224163001145 putative homodimer interface [polypeptide binding]; other site 1224163001146 putative allosteric switch controlling residues; other site 1224163001147 putative metal binding site [ion binding]; other site 1224163001148 putative homodimer-homodimer interface [polypeptide binding]; other site 1224163001149 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 1224163001150 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1224163001151 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1224163001152 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 1224163001153 active site residue [active] 1224163001154 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 1224163001155 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1224163001156 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1224163001157 acyl-activating enzyme (AAE) consensus motif; other site 1224163001158 AMP binding site [chemical binding]; other site 1224163001159 active site 1224163001160 CoA binding site [chemical binding]; other site 1224163001161 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1224163001162 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1224163001163 putative ADP-binding pocket [chemical binding]; other site 1224163001164 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1224163001165 catalytic core [active] 1224163001166 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1224163001167 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1224163001168 dimer interface [polypeptide binding]; other site 1224163001169 phosphorylation site [posttranslational modification] 1224163001170 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1224163001171 ATP binding site [chemical binding]; other site 1224163001172 Mg2+ binding site [ion binding]; other site 1224163001173 G-X-G motif; other site 1224163001174 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1224163001175 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1224163001176 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1224163001177 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1224163001178 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1224163001179 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1224163001180 DNA binding domain, excisionase family; Region: excise; TIGR01764 1224163001181 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1224163001182 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 1224163001183 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1224163001184 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1224163001185 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1224163001186 tRNA; other site 1224163001187 putative tRNA binding site [nucleotide binding]; other site 1224163001188 putative NADP binding site [chemical binding]; other site 1224163001189 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1224163001190 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1224163001191 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1224163001192 domain interfaces; other site 1224163001193 active site 1224163001194 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1224163001195 active site 1224163001196 homodimer interface [polypeptide binding]; other site 1224163001197 SAM binding site [chemical binding]; other site 1224163001198 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1224163001199 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1224163001200 active site 1224163001201 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1224163001202 dimer interface [polypeptide binding]; other site 1224163001203 active site 1224163001204 Schiff base residues; other site 1224163001205 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1224163001206 substrate binding site [chemical binding]; other site 1224163001207 active site 1224163001208 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1224163001209 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1224163001210 active site 1224163001211 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1224163001212 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1224163001213 inhibitor-cofactor binding pocket; inhibition site 1224163001214 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1224163001215 catalytic residue [active] 1224163001216 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1224163001217 catalytic core [active] 1224163001218 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 1224163001219 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1224163001220 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1224163001221 catalytic residues [active] 1224163001222 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1224163001223 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1224163001224 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1224163001225 ResB-like family; Region: ResB; pfam05140 1224163001226 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1224163001227 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1224163001228 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1224163001229 motif II; other site 1224163001230 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1224163001231 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1224163001232 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1224163001233 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1224163001234 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1224163001235 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1224163001236 non-specific DNA binding site [nucleotide binding]; other site 1224163001237 salt bridge; other site 1224163001238 sequence-specific DNA binding site [nucleotide binding]; other site 1224163001239 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 1224163001240 Predicted permeases [General function prediction only]; Region: COG0679 1224163001241 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1224163001242 UbiA prenyltransferase family; Region: UbiA; pfam01040 1224163001243 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1224163001244 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1224163001245 acyl-activating enzyme (AAE) consensus motif; other site 1224163001246 AMP binding site [chemical binding]; other site 1224163001247 active site 1224163001248 CoA binding site [chemical binding]; other site 1224163001249 DoxX; Region: DoxX; pfam07681 1224163001250 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1224163001251 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1224163001252 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1224163001253 PhnA protein; Region: PhnA; pfam03831 1224163001254 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1224163001255 active site 1224163001256 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1224163001257 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1224163001258 substrate binding site [chemical binding]; other site 1224163001259 oxyanion hole (OAH) forming residues; other site 1224163001260 trimer interface [polypeptide binding]; other site 1224163001261 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1224163001262 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1224163001263 aromatic arch; other site 1224163001264 DCoH dimer interaction site [polypeptide binding]; other site 1224163001265 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1224163001266 DCoH tetramer interaction site [polypeptide binding]; other site 1224163001267 substrate binding site [chemical binding]; other site 1224163001268 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1224163001269 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1224163001270 active site 1224163001271 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1224163001272 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1224163001273 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1224163001274 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1224163001275 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1224163001276 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1224163001277 ABC transporter signature motif; other site 1224163001278 Walker B; other site 1224163001279 D-loop; other site 1224163001280 H-loop/switch region; other site 1224163001281 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1224163001282 Walker A/P-loop; other site 1224163001283 ATP binding site [chemical binding]; other site 1224163001284 Q-loop/lid; other site 1224163001285 ABC transporter signature motif; other site 1224163001286 Walker B; other site 1224163001287 D-loop; other site 1224163001288 H-loop/switch region; other site 1224163001289 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1224163001290 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1224163001291 dimer interface [polypeptide binding]; other site 1224163001292 tetramer interface [polypeptide binding]; other site 1224163001293 PYR/PP interface [polypeptide binding]; other site 1224163001294 TPP binding site [chemical binding]; other site 1224163001295 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1224163001296 TPP-binding site; other site 1224163001297 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1224163001298 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1224163001299 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1224163001300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1224163001301 S-adenosylmethionine binding site [chemical binding]; other site 1224163001302 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1224163001303 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1224163001304 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1224163001305 substrate binding pocket [chemical binding]; other site 1224163001306 chain length determination region; other site 1224163001307 substrate-Mg2+ binding site; other site 1224163001308 catalytic residues [active] 1224163001309 aspartate-rich region 1; other site 1224163001310 active site lid residues [active] 1224163001311 aspartate-rich region 2; other site 1224163001312 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1224163001313 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1224163001314 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1224163001315 putative homodimer interface [polypeptide binding]; other site 1224163001316 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1224163001317 heterodimer interface [polypeptide binding]; other site 1224163001318 homodimer interface [polypeptide binding]; other site 1224163001319 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1224163001320 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1224163001321 23S rRNA interface [nucleotide binding]; other site 1224163001322 L7/L12 interface [polypeptide binding]; other site 1224163001323 putative thiostrepton binding site; other site 1224163001324 L25 interface [polypeptide binding]; other site 1224163001325 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1224163001326 mRNA/rRNA interface [nucleotide binding]; other site 1224163001327 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1224163001328 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1224163001329 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1224163001330 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1224163001331 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1224163001332 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1224163001333 FtsX-like permease family; Region: FtsX; pfam02687 1224163001334 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1224163001335 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1224163001336 Walker A/P-loop; other site 1224163001337 ATP binding site [chemical binding]; other site 1224163001338 Q-loop/lid; other site 1224163001339 ABC transporter signature motif; other site 1224163001340 Walker B; other site 1224163001341 D-loop; other site 1224163001342 H-loop/switch region; other site 1224163001343 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1224163001344 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1224163001345 23S rRNA interface [nucleotide binding]; other site 1224163001346 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1224163001347 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1224163001348 L11 interface [polypeptide binding]; other site 1224163001349 putative EF-Tu interaction site [polypeptide binding]; other site 1224163001350 putative EF-G interaction site [polypeptide binding]; other site 1224163001351 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1224163001352 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1224163001353 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1224163001354 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1224163001355 RPB1 interaction site [polypeptide binding]; other site 1224163001356 RPB10 interaction site [polypeptide binding]; other site 1224163001357 RPB11 interaction site [polypeptide binding]; other site 1224163001358 RPB3 interaction site [polypeptide binding]; other site 1224163001359 RPB12 interaction site [polypeptide binding]; other site 1224163001360 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1224163001361 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1224163001362 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1224163001363 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1224163001364 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1224163001365 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1224163001366 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1224163001367 G-loop; other site 1224163001368 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1224163001369 DNA binding site [nucleotide binding] 1224163001370 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1224163001371 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1224163001372 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1224163001373 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 1224163001374 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1224163001375 substrate binding sites [chemical binding]; other site 1224163001376 IncA protein; Region: IncA; pfam04156 1224163001377 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1224163001378 Tubulin like; Region: Tubulin_2; pfam13809 1224163001379 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1224163001380 S17 interaction site [polypeptide binding]; other site 1224163001381 S8 interaction site; other site 1224163001382 16S rRNA interaction site [nucleotide binding]; other site 1224163001383 streptomycin interaction site [chemical binding]; other site 1224163001384 23S rRNA interaction site [nucleotide binding]; other site 1224163001385 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1224163001386 30S ribosomal protein S7; Validated; Region: PRK05302 1224163001387 elongation factor G; Reviewed; Region: PRK00007 1224163001388 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1224163001389 G1 box; other site 1224163001390 putative GEF interaction site [polypeptide binding]; other site 1224163001391 GTP/Mg2+ binding site [chemical binding]; other site 1224163001392 Switch I region; other site 1224163001393 G2 box; other site 1224163001394 G3 box; other site 1224163001395 Switch II region; other site 1224163001396 G4 box; other site 1224163001397 G5 box; other site 1224163001398 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1224163001399 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1224163001400 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1224163001401 elongation factor Tu; Reviewed; Region: PRK00049 1224163001402 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1224163001403 G1 box; other site 1224163001404 GEF interaction site [polypeptide binding]; other site 1224163001405 GTP/Mg2+ binding site [chemical binding]; other site 1224163001406 Switch I region; other site 1224163001407 G2 box; other site 1224163001408 G3 box; other site 1224163001409 Switch II region; other site 1224163001410 G4 box; other site 1224163001411 G5 box; other site 1224163001412 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1224163001413 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1224163001414 Antibiotic Binding Site [chemical binding]; other site 1224163001415 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1224163001416 Asp23 family; Region: Asp23; pfam03780 1224163001417 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1224163001418 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1224163001419 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1224163001420 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1224163001421 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1224163001422 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1224163001423 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1224163001424 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1224163001425 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1224163001426 putative translocon binding site; other site 1224163001427 protein-rRNA interface [nucleotide binding]; other site 1224163001428 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1224163001429 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1224163001430 G-X-X-G motif; other site 1224163001431 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1224163001432 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1224163001433 23S rRNA interface [nucleotide binding]; other site 1224163001434 5S rRNA interface [nucleotide binding]; other site 1224163001435 putative antibiotic binding site [chemical binding]; other site 1224163001436 L25 interface [polypeptide binding]; other site 1224163001437 L27 interface [polypeptide binding]; other site 1224163001438 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1224163001439 23S rRNA interface [nucleotide binding]; other site 1224163001440 putative translocon interaction site; other site 1224163001441 signal recognition particle (SRP54) interaction site; other site 1224163001442 L23 interface [polypeptide binding]; other site 1224163001443 trigger factor interaction site; other site 1224163001444 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1224163001445 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1224163001446 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1224163001447 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1224163001448 RNA binding site [nucleotide binding]; other site 1224163001449 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1224163001450 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1224163001451 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1224163001452 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1224163001453 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1224163001454 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1224163001455 metal binding site [ion binding]; metal-binding site 1224163001456 putative dimer interface [polypeptide binding]; other site 1224163001457 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 1224163001458 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1224163001459 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1224163001460 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1224163001461 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1224163001462 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1224163001463 5S rRNA interface [nucleotide binding]; other site 1224163001464 L27 interface [polypeptide binding]; other site 1224163001465 23S rRNA interface [nucleotide binding]; other site 1224163001466 L5 interface [polypeptide binding]; other site 1224163001467 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1224163001468 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1224163001469 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1224163001470 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1224163001471 23S rRNA binding site [nucleotide binding]; other site 1224163001472 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1224163001473 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1224163001474 SecY translocase; Region: SecY; pfam00344 1224163001475 adenylate kinase; Reviewed; Region: adk; PRK00279 1224163001476 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1224163001477 AMP-binding site [chemical binding]; other site 1224163001478 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1224163001479 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1224163001480 active site 1224163001481 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1224163001482 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1224163001483 rRNA binding site [nucleotide binding]; other site 1224163001484 predicted 30S ribosome binding site; other site 1224163001485 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 1224163001486 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1224163001487 30S ribosomal protein S11; Validated; Region: PRK05309 1224163001488 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1224163001489 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1224163001490 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1224163001491 RNA binding surface [nucleotide binding]; other site 1224163001492 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1224163001493 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1224163001494 alphaNTD - beta interaction site [polypeptide binding]; other site 1224163001495 alphaNTD homodimer interface [polypeptide binding]; other site 1224163001496 alphaNTD - beta' interaction site [polypeptide binding]; other site 1224163001497 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1224163001498 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1224163001499 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1224163001500 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1224163001501 dimerization interface 3.5A [polypeptide binding]; other site 1224163001502 active site 1224163001503 Protein of unknown function (DUF690); Region: DUF690; cl04939 1224163001504 FAD binding domain; Region: FAD_binding_4; pfam01565 1224163001505 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1224163001506 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1224163001507 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1224163001508 S-adenosylmethionine binding site [chemical binding]; other site 1224163001509 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 1224163001510 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1224163001511 active site 1224163001512 catalytic residues [active] 1224163001513 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1224163001514 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1224163001515 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1224163001516 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1224163001517 catalytic residues [active] 1224163001518 catalytic nucleophile [active] 1224163001519 Recombinase; Region: Recombinase; pfam07508 1224163001520 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 1224163001521 polymerase nucleotide-binding site; other site 1224163001522 DNA-binding residues [nucleotide binding]; DNA binding site 1224163001523 nucleotide binding site [chemical binding]; other site 1224163001524 primase nucleotide-binding site [nucleotide binding]; other site 1224163001525 AAA domain; Region: AAA_25; pfam13481 1224163001526 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1224163001527 Walker A motif; other site 1224163001528 ATP binding site [chemical binding]; other site 1224163001529 Walker B motif; other site 1224163001530 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1224163001531 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1224163001532 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1224163001533 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1224163001534 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1224163001535 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1224163001536 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1224163001537 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1224163001538 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1224163001539 23S rRNA interface [nucleotide binding]; other site 1224163001540 L3 interface [polypeptide binding]; other site 1224163001541 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1224163001542 Probable beta-xylosidase; Provisional; Region: PLN03080 1224163001543 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1224163001544 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1224163001545 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1224163001546 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1224163001547 active site 1224163001548 substrate binding site [chemical binding]; other site 1224163001549 metal binding site [ion binding]; metal-binding site 1224163001550 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1224163001551 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1224163001552 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1224163001553 glutaminase active site [active] 1224163001554 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1224163001555 dimer interface [polypeptide binding]; other site 1224163001556 active site 1224163001557 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1224163001558 dimer interface [polypeptide binding]; other site 1224163001559 active site 1224163001560 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1224163001561 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1224163001562 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1224163001563 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1224163001564 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1224163001565 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1224163001566 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1224163001567 substrate binding pocket [chemical binding]; other site 1224163001568 dimerization interface [polypeptide binding]; other site 1224163001569 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1224163001570 Cytochrome P450; Region: p450; cl12078 1224163001571 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1224163001572 Cation efflux family; Region: Cation_efflux; pfam01545 1224163001573 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1224163001574 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1224163001575 FAD binding domain; Region: FAD_binding_3; pfam01494 1224163001576 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 1224163001577 alanine racemase; Reviewed; Region: alr; PRK00053 1224163001578 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1224163001579 active site 1224163001580 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1224163001581 dimer interface [polypeptide binding]; other site 1224163001582 substrate binding site [chemical binding]; other site 1224163001583 catalytic residues [active] 1224163001584 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1224163001585 Predicted permease [General function prediction only]; Region: COG2985 1224163001586 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1224163001587 TrkA-C domain; Region: TrkA_C; pfam02080 1224163001588 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1224163001589 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1224163001590 Glycoprotease family; Region: Peptidase_M22; pfam00814 1224163001591 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1224163001592 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1224163001593 Coenzyme A binding pocket [chemical binding]; other site 1224163001594 UGMP family protein; Validated; Region: PRK09604 1224163001595 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1224163001596 oligomerisation interface [polypeptide binding]; other site 1224163001597 mobile loop; other site 1224163001598 roof hairpin; other site 1224163001599 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1224163001600 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1224163001601 ring oligomerisation interface [polypeptide binding]; other site 1224163001602 ATP/Mg binding site [chemical binding]; other site 1224163001603 stacking interactions; other site 1224163001604 hinge regions; other site 1224163001605 Transcription factor WhiB; Region: Whib; pfam02467 1224163001606 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1224163001607 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1224163001608 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1224163001609 DNA binding residues [nucleotide binding] 1224163001610 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1224163001611 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1224163001612 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1224163001613 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1224163001614 active site 1224163001615 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1224163001616 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1224163001617 phosphate binding site [ion binding]; other site 1224163001618 GMP synthase; Reviewed; Region: guaA; PRK00074 1224163001619 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1224163001620 AMP/PPi binding site [chemical binding]; other site 1224163001621 candidate oxyanion hole; other site 1224163001622 catalytic triad [active] 1224163001623 potential glutamine specificity residues [chemical binding]; other site 1224163001624 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1224163001625 ATP Binding subdomain [chemical binding]; other site 1224163001626 Ligand Binding sites [chemical binding]; other site 1224163001627 Dimerization subdomain; other site 1224163001628 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 1224163001629 PspC domain; Region: PspC; pfam04024 1224163001630 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1224163001631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1224163001632 ATP binding site [chemical binding]; other site 1224163001633 Mg2+ binding site [ion binding]; other site 1224163001634 G-X-G motif; other site 1224163001635 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1224163001636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1224163001637 active site 1224163001638 phosphorylation site [posttranslational modification] 1224163001639 intermolecular recognition site; other site 1224163001640 dimerization interface [polypeptide binding]; other site 1224163001641 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1224163001642 DNA binding residues [nucleotide binding] 1224163001643 dimerization interface [polypeptide binding]; other site 1224163001644 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1224163001645 active site 1224163001646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1224163001647 dimer interface [polypeptide binding]; other site 1224163001648 conserved gate region; other site 1224163001649 putative PBP binding loops; other site 1224163001650 ABC-ATPase subunit interface; other site 1224163001651 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1224163001652 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1224163001653 Walker A/P-loop; other site 1224163001654 ATP binding site [chemical binding]; other site 1224163001655 Q-loop/lid; other site 1224163001656 ABC transporter signature motif; other site 1224163001657 Walker B; other site 1224163001658 D-loop; other site 1224163001659 H-loop/switch region; other site 1224163001660 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1224163001661 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1224163001662 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1224163001663 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1224163001664 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1224163001665 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1224163001666 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1224163001667 ABC-ATPase subunit interface; other site 1224163001668 dimer interface [polypeptide binding]; other site 1224163001669 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1224163001670 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1224163001671 ABC-ATPase subunit interface; other site 1224163001672 dimer interface [polypeptide binding]; other site 1224163001673 putative PBP binding regions; other site 1224163001674 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1224163001675 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1224163001676 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1224163001677 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1224163001678 intersubunit interface [polypeptide binding]; other site 1224163001679 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1224163001680 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1224163001681 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1224163001682 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1224163001683 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1224163001684 Predicted membrane protein [Function unknown]; Region: COG3428 1224163001685 Bacterial PH domain; Region: DUF304; pfam03703 1224163001686 Bacterial PH domain; Region: DUF304; cl01348 1224163001687 Bacterial PH domain; Region: DUF304; pfam03703 1224163001688 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1224163001689 MOSC domain; Region: MOSC; pfam03473 1224163001690 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1224163001691 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1224163001692 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1224163001693 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1224163001694 homodimer interface [polypeptide binding]; other site 1224163001695 NADP binding site [chemical binding]; other site 1224163001696 substrate binding site [chemical binding]; other site 1224163001697 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1224163001698 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1224163001699 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1224163001700 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05613 1224163001701 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1224163001702 homodimer interface [polypeptide binding]; other site 1224163001703 substrate-cofactor binding pocket; other site 1224163001704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1224163001705 catalytic residue [active] 1224163001706 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1224163001707 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1224163001708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163001709 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1224163001710 putative substrate translocation pore; other site 1224163001711 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1224163001712 putative catalytic site [active] 1224163001713 putative metal binding site [ion binding]; other site 1224163001714 putative phosphate binding site [ion binding]; other site 1224163001715 Predicted membrane protein [Function unknown]; Region: COG2860 1224163001716 UPF0126 domain; Region: UPF0126; pfam03458 1224163001717 UPF0126 domain; Region: UPF0126; pfam03458 1224163001718 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1224163001719 DNA-binding site [nucleotide binding]; DNA binding site 1224163001720 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1224163001721 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1224163001722 active site 1224163001723 HIGH motif; other site 1224163001724 dimer interface [polypeptide binding]; other site 1224163001725 KMSKS motif; other site 1224163001726 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1224163001727 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1224163001728 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1224163001729 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1224163001730 active site 1224163001731 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1224163001732 NlpC/P60 family; Region: NLPC_P60; pfam00877 1224163001733 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1224163001734 active site 1224163001735 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1224163001736 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1224163001737 non-specific DNA binding site [nucleotide binding]; other site 1224163001738 salt bridge; other site 1224163001739 sequence-specific DNA binding site [nucleotide binding]; other site 1224163001740 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1224163001741 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1224163001742 metal binding site [ion binding]; metal-binding site 1224163001743 putative dimer interface [polypeptide binding]; other site 1224163001744 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1224163001745 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1224163001746 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1224163001747 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1224163001748 malate synthase G; Provisional; Region: PRK02999 1224163001749 active site 1224163001750 isocitrate lyase; Provisional; Region: PRK15063 1224163001751 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1224163001752 tetramer interface [polypeptide binding]; other site 1224163001753 active site 1224163001754 Mg2+/Mn2+ binding site [ion binding]; other site 1224163001755 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1224163001756 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1224163001757 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1224163001758 sequence-specific DNA binding site [nucleotide binding]; other site 1224163001759 salt bridge; other site 1224163001760 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1224163001761 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1224163001762 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1224163001763 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1224163001764 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1224163001765 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1224163001766 tetramer interface [polypeptide binding]; other site 1224163001767 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1224163001768 active site 1224163001769 Mg2+/Mn2+ binding site [ion binding]; other site 1224163001770 citrate synthase; Provisional; Region: PRK14033 1224163001771 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1224163001772 oxalacetate binding site [chemical binding]; other site 1224163001773 citrylCoA binding site [chemical binding]; other site 1224163001774 coenzyme A binding site [chemical binding]; other site 1224163001775 catalytic triad [active] 1224163001776 pyruvate carboxylase; Reviewed; Region: PRK12999 1224163001777 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1224163001778 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1224163001779 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1224163001780 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1224163001781 active site 1224163001782 catalytic residues [active] 1224163001783 metal binding site [ion binding]; metal-binding site 1224163001784 homodimer binding site [polypeptide binding]; other site 1224163001785 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1224163001786 carboxyltransferase (CT) interaction site; other site 1224163001787 biotinylation site [posttranslational modification]; other site 1224163001788 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1224163001789 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1224163001790 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1224163001791 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1224163001792 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1224163001793 carboxyltransferase (CT) interaction site; other site 1224163001794 biotinylation site [posttranslational modification]; other site 1224163001795 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1224163001796 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1224163001797 active site residue [active] 1224163001798 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1224163001799 active site residue [active] 1224163001800 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 1224163001801 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1224163001802 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1224163001803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1224163001804 dimer interface [polypeptide binding]; other site 1224163001805 conserved gate region; other site 1224163001806 putative PBP binding loops; other site 1224163001807 ABC-ATPase subunit interface; other site 1224163001808 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1224163001809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1224163001810 dimer interface [polypeptide binding]; other site 1224163001811 conserved gate region; other site 1224163001812 putative PBP binding loops; other site 1224163001813 ABC-ATPase subunit interface; other site 1224163001814 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1224163001815 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1224163001816 Walker A/P-loop; other site 1224163001817 ATP binding site [chemical binding]; other site 1224163001818 Q-loop/lid; other site 1224163001819 ABC transporter signature motif; other site 1224163001820 Walker B; other site 1224163001821 D-loop; other site 1224163001822 H-loop/switch region; other site 1224163001823 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1224163001824 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 1224163001825 Walker A/P-loop; other site 1224163001826 ATP binding site [chemical binding]; other site 1224163001827 Q-loop/lid; other site 1224163001828 ABC transporter signature motif; other site 1224163001829 Walker B; other site 1224163001830 D-loop; other site 1224163001831 H-loop/switch region; other site 1224163001832 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1224163001833 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1224163001834 putative NAD(P) binding site [chemical binding]; other site 1224163001835 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1224163001836 metal-binding site [ion binding] 1224163001837 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1224163001838 Cation efflux family; Region: Cation_efflux; cl00316 1224163001839 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1224163001840 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1224163001841 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1224163001842 motif II; other site 1224163001843 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1224163001844 dimerization interface [polypeptide binding]; other site 1224163001845 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1224163001846 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1224163001847 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1224163001848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1224163001849 active site 1224163001850 phosphorylation site [posttranslational modification] 1224163001851 intermolecular recognition site; other site 1224163001852 dimerization interface [polypeptide binding]; other site 1224163001853 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1224163001854 DNA binding site [nucleotide binding] 1224163001855 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1224163001856 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1224163001857 dimerization interface [polypeptide binding]; other site 1224163001858 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1224163001859 dimer interface [polypeptide binding]; other site 1224163001860 phosphorylation site [posttranslational modification] 1224163001861 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1224163001862 ATP binding site [chemical binding]; other site 1224163001863 Mg2+ binding site [ion binding]; other site 1224163001864 G-X-G motif; other site 1224163001865 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1224163001866 metal-binding site [ion binding] 1224163001867 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1224163001868 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1224163001869 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1224163001870 motif I; other site 1224163001871 motif II; other site 1224163001872 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1224163001873 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1224163001874 S-adenosylmethionine binding site [chemical binding]; other site 1224163001875 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 1224163001876 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1224163001877 Moco binding site; other site 1224163001878 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1224163001879 metal coordination site [ion binding]; other site 1224163001880 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1224163001881 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1224163001882 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1224163001883 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1224163001884 Maf-like protein; Region: Maf; pfam02545 1224163001885 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1224163001886 active site 1224163001887 dimer interface [polypeptide binding]; other site 1224163001888 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1224163001889 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1224163001890 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1224163001891 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1224163001892 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1224163001893 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 1224163001894 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1224163001895 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1224163001896 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1224163001897 Bacterial PH domain; Region: DUF304; cl01348 1224163001898 metabolite-proton symporter; Region: 2A0106; TIGR00883 1224163001899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163001900 putative substrate translocation pore; other site 1224163001901 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1224163001902 ATP-grasp domain; Region: ATP-grasp; pfam02222 1224163001903 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1224163001904 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1224163001905 putative active site [active] 1224163001906 TIGR03089 family protein; Region: TIGR03089 1224163001907 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 1224163001908 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1224163001909 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1224163001910 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1224163001911 Probable Catalytic site; other site 1224163001912 metal-binding site 1224163001913 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1224163001914 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1224163001915 active site 1224163001916 Substrate binding site; other site 1224163001917 Mg++ binding site; other site 1224163001918 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1224163001919 putative trimer interface [polypeptide binding]; other site 1224163001920 putative CoA binding site [chemical binding]; other site 1224163001921 Transcription factor WhiB; Region: Whib; pfam02467 1224163001922 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1224163001923 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1224163001924 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1224163001925 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1224163001926 active site 1224163001927 substrate binding site [chemical binding]; other site 1224163001928 metal binding site [ion binding]; metal-binding site 1224163001929 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1224163001930 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1224163001931 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1224163001932 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1224163001933 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1224163001934 homotetramer interface [polypeptide binding]; other site 1224163001935 ligand binding site [chemical binding]; other site 1224163001936 catalytic site [active] 1224163001937 NAD binding site [chemical binding]; other site 1224163001938 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1224163001939 TMP-binding site; other site 1224163001940 ATP-binding site [chemical binding]; other site 1224163001941 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1224163001942 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1224163001943 active site 1224163001944 phosphorylation site [posttranslational modification] 1224163001945 intermolecular recognition site; other site 1224163001946 dimerization interface [polypeptide binding]; other site 1224163001947 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1224163001948 DNA binding site [nucleotide binding] 1224163001949 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1224163001950 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1224163001951 dimerization interface [polypeptide binding]; other site 1224163001952 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1224163001953 dimer interface [polypeptide binding]; other site 1224163001954 phosphorylation site [posttranslational modification] 1224163001955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1224163001956 ATP binding site [chemical binding]; other site 1224163001957 Mg2+ binding site [ion binding]; other site 1224163001958 G-X-G motif; other site 1224163001959 lipoprotein LpqB; Provisional; Region: PRK13616 1224163001960 Sporulation and spore germination; Region: Germane; pfam10646 1224163001961 comF family protein; Region: comF; TIGR00201 1224163001962 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1224163001963 active site 1224163001964 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1224163001965 30S subunit binding site; other site 1224163001966 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1224163001967 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1224163001968 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1224163001969 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1224163001970 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1224163001971 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1224163001972 nucleotide binding region [chemical binding]; other site 1224163001973 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1224163001974 Predicted GTPases [General function prediction only]; Region: COG1162 1224163001975 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1224163001976 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1224163001977 GTP/Mg2+ binding site [chemical binding]; other site 1224163001978 G4 box; other site 1224163001979 G5 box; other site 1224163001980 G1 box; other site 1224163001981 Switch I region; other site 1224163001982 G2 box; other site 1224163001983 G3 box; other site 1224163001984 Switch II region; other site 1224163001985 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1224163001986 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1224163001987 hinge; other site 1224163001988 active site 1224163001989 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1224163001990 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1224163001991 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1224163001992 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1224163001993 DNA binding residues [nucleotide binding] 1224163001994 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 1224163001995 Transcription factor WhiB; Region: Whib; pfam02467 1224163001996 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1224163001997 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1224163001998 ATP binding site [chemical binding]; other site 1224163001999 Mg++ binding site [ion binding]; other site 1224163002000 motif III; other site 1224163002001 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1224163002002 nucleotide binding region [chemical binding]; other site 1224163002003 ATP-binding site [chemical binding]; other site 1224163002004 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1224163002005 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1224163002006 TIGR02569 family protein; Region: TIGR02569_actnb 1224163002007 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1224163002008 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1224163002009 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1224163002010 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1224163002011 Ion channel; Region: Ion_trans_2; pfam07885 1224163002012 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1224163002013 TrkA-N domain; Region: TrkA_N; pfam02254 1224163002014 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1224163002015 putative NADH binding site [chemical binding]; other site 1224163002016 putative active site [active] 1224163002017 nudix motif; other site 1224163002018 putative metal binding site [ion binding]; other site 1224163002019 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1224163002020 Part of AAA domain; Region: AAA_19; pfam13245 1224163002021 Family description; Region: UvrD_C_2; pfam13538 1224163002022 HRDC domain; Region: HRDC; pfam00570 1224163002023 Protein of unknown function DUF45; Region: DUF45; cl00636 1224163002024 putative hydrolase; Region: TIGR03624 1224163002025 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1224163002026 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1224163002027 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1224163002028 hypothetical protein; Validated; Region: PRK00068 1224163002029 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 1224163002030 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1224163002031 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1224163002032 active site 1224163002033 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1224163002034 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1224163002035 active site 1224163002036 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1224163002037 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1224163002038 RF-1 domain; Region: RF-1; pfam00472 1224163002039 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1224163002040 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1224163002041 Walker A/P-loop; other site 1224163002042 ATP binding site [chemical binding]; other site 1224163002043 Q-loop/lid; other site 1224163002044 ABC transporter signature motif; other site 1224163002045 Walker B; other site 1224163002046 D-loop; other site 1224163002047 H-loop/switch region; other site 1224163002048 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1224163002049 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1224163002050 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1224163002051 SmpB-tmRNA interface; other site 1224163002052 Protein of unknown function, DUF488; Region: DUF488; cl01246 1224163002053 short chain dehydrogenase; Provisional; Region: PRK08219 1224163002054 classical (c) SDRs; Region: SDR_c; cd05233 1224163002055 NAD(P) binding site [chemical binding]; other site 1224163002056 active site 1224163002057 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1224163002058 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1224163002059 intersubunit interface [polypeptide binding]; other site 1224163002060 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1224163002061 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1224163002062 ABC-ATPase subunit interface; other site 1224163002063 dimer interface [polypeptide binding]; other site 1224163002064 putative PBP binding regions; other site 1224163002065 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1224163002066 ABC-ATPase subunit interface; other site 1224163002067 dimer interface [polypeptide binding]; other site 1224163002068 putative PBP binding regions; other site 1224163002069 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1224163002070 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1224163002071 Walker A/P-loop; other site 1224163002072 ATP binding site [chemical binding]; other site 1224163002073 Q-loop/lid; other site 1224163002074 ABC transporter signature motif; other site 1224163002075 Walker B; other site 1224163002076 D-loop; other site 1224163002077 H-loop/switch region; other site 1224163002078 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1224163002079 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 1224163002080 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1224163002081 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1224163002082 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1224163002083 ATP binding site [chemical binding]; other site 1224163002084 putative Mg++ binding site [ion binding]; other site 1224163002085 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1224163002086 nucleotide binding region [chemical binding]; other site 1224163002087 ATP-binding site [chemical binding]; other site 1224163002088 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1224163002089 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1224163002090 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1224163002091 Walker A/P-loop; other site 1224163002092 ATP binding site [chemical binding]; other site 1224163002093 Q-loop/lid; other site 1224163002094 ABC transporter signature motif; other site 1224163002095 Walker B; other site 1224163002096 D-loop; other site 1224163002097 H-loop/switch region; other site 1224163002098 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1224163002099 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1224163002100 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1224163002101 non-specific DNA binding site [nucleotide binding]; other site 1224163002102 salt bridge; other site 1224163002103 sequence-specific DNA binding site [nucleotide binding]; other site 1224163002104 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1224163002105 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1224163002106 Protein of unknown function (DUF3235); Region: DUF3235; pfam11574 1224163002107 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1224163002108 DNA-binding site [nucleotide binding]; DNA binding site 1224163002109 RNA-binding motif; other site 1224163002110 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 1224163002111 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 1224163002112 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1224163002113 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1224163002114 substrate-cofactor binding pocket; other site 1224163002115 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1224163002116 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1224163002117 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1224163002118 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1224163002119 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1224163002120 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1224163002121 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1224163002122 catalytic residue [active] 1224163002123 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1224163002124 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1224163002125 dimer interface [polypeptide binding]; other site 1224163002126 active site 1224163002127 citrylCoA binding site [chemical binding]; other site 1224163002128 NADH binding [chemical binding]; other site 1224163002129 cationic pore residues; other site 1224163002130 oxalacetate/citrate binding site [chemical binding]; other site 1224163002131 coenzyme A binding site [chemical binding]; other site 1224163002132 catalytic triad [active] 1224163002133 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1224163002134 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1224163002135 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1224163002136 active site 1224163002137 catalytic tetrad [active] 1224163002138 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1224163002139 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1224163002140 Na binding site [ion binding]; other site 1224163002141 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1224163002142 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1224163002143 amidohydrolase; Region: amidohydrolases; TIGR01891 1224163002144 metal binding site [ion binding]; metal-binding site 1224163002145 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1224163002146 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1224163002147 AAA domain; Region: AAA_25; pfam13481 1224163002148 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 1224163002149 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1224163002150 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1224163002151 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1224163002152 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1224163002153 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1224163002154 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1224163002155 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1224163002156 catalytic residues [active] 1224163002157 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1224163002158 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1224163002159 folate binding site [chemical binding]; other site 1224163002160 NADP+ binding site [chemical binding]; other site 1224163002161 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1224163002162 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1224163002163 dimerization interface [polypeptide binding]; other site 1224163002164 active site 1224163002165 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1224163002166 active site 1224163002167 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1224163002168 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1224163002169 ATP binding site [chemical binding]; other site 1224163002170 putative Mg++ binding site [ion binding]; other site 1224163002171 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1224163002172 nucleotide binding region [chemical binding]; other site 1224163002173 ATP-binding site [chemical binding]; other site 1224163002174 DEAD/H associated; Region: DEAD_assoc; pfam08494 1224163002175 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1224163002176 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1224163002177 putative DNA binding site [nucleotide binding]; other site 1224163002178 catalytic residue [active] 1224163002179 putative H2TH interface [polypeptide binding]; other site 1224163002180 putative catalytic residues [active] 1224163002181 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1224163002182 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1224163002183 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1224163002184 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1224163002185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163002186 hypothetical protein; Provisional; Region: PRK11770 1224163002187 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1224163002188 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1224163002189 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1224163002190 active site 1224163002191 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1224163002192 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1224163002193 active site 1224163002194 dimer interface [polypeptide binding]; other site 1224163002195 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1224163002196 dimer interface [polypeptide binding]; other site 1224163002197 active site 1224163002198 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1224163002199 hypothetical protein; Provisional; Region: PRK07857 1224163002200 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1224163002201 Part of AAA domain; Region: AAA_19; pfam13245 1224163002202 Family description; Region: UvrD_C_2; pfam13538 1224163002203 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1224163002204 Peptidase family M23; Region: Peptidase_M23; pfam01551 1224163002205 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1224163002206 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1224163002207 active site 1224163002208 substrate binding site [chemical binding]; other site 1224163002209 cosubstrate binding site; other site 1224163002210 catalytic site [active] 1224163002211 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1224163002212 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1224163002213 purine monophosphate binding site [chemical binding]; other site 1224163002214 dimer interface [polypeptide binding]; other site 1224163002215 putative catalytic residues [active] 1224163002216 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1224163002217 30S ribosomal protein S18; Provisional; Region: PRK13401 1224163002218 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1224163002219 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1224163002220 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1224163002221 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1224163002222 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1224163002223 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1224163002224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1224163002225 active site 1224163002226 phosphorylation site [posttranslational modification] 1224163002227 intermolecular recognition site; other site 1224163002228 dimerization interface [polypeptide binding]; other site 1224163002229 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1224163002230 DNA binding site [nucleotide binding] 1224163002231 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1224163002232 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1224163002233 dimerization interface [polypeptide binding]; other site 1224163002234 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1224163002235 phosphorylation site [posttranslational modification] 1224163002236 dimer interface [polypeptide binding]; other site 1224163002237 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1224163002238 ATP binding site [chemical binding]; other site 1224163002239 Mg2+ binding site [ion binding]; other site 1224163002240 G-X-G motif; other site 1224163002241 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1224163002242 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1224163002243 protein binding site [polypeptide binding]; other site 1224163002244 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 1224163002245 MPT binding site; other site 1224163002246 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1224163002247 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1224163002248 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1224163002249 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1224163002250 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1224163002251 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 1224163002252 active site 1224163002253 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1224163002254 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1224163002255 dimer interface [polypeptide binding]; other site 1224163002256 putative functional site; other site 1224163002257 putative MPT binding site; other site 1224163002258 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1224163002259 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1224163002260 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1224163002261 Predicted membrane protein [Function unknown]; Region: COG2259 1224163002262 Predicted integral membrane protein [Function unknown]; Region: COG5660 1224163002263 Putative zinc-finger; Region: zf-HC2; pfam13490 1224163002264 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1224163002265 Predicted methyltransferases [General function prediction only]; Region: COG0313 1224163002266 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1224163002267 putative SAM binding site [chemical binding]; other site 1224163002268 putative homodimer interface [polypeptide binding]; other site 1224163002269 BCCT family transporter; Region: BCCT; pfam02028 1224163002270 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1224163002271 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1224163002272 active site 1224163002273 HIGH motif; other site 1224163002274 KMSKS motif; other site 1224163002275 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1224163002276 tRNA binding surface [nucleotide binding]; other site 1224163002277 anticodon binding site; other site 1224163002278 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1224163002279 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1224163002280 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1224163002281 ATP binding site [chemical binding]; other site 1224163002282 putative Mg++ binding site [ion binding]; other site 1224163002283 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1224163002284 nucleotide binding region [chemical binding]; other site 1224163002285 ATP-binding site [chemical binding]; other site 1224163002286 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1224163002287 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1224163002288 Coenzyme A binding pocket [chemical binding]; other site 1224163002289 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1224163002290 active site 1224163002291 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1224163002292 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1224163002293 G5 domain; Region: G5; pfam07501 1224163002294 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1224163002295 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1224163002296 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1224163002297 proposed catalytic triad [active] 1224163002298 conserved cys residue [active] 1224163002299 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1224163002300 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1224163002301 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1224163002302 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1224163002303 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1224163002304 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1224163002305 ABC transporter; Region: ABC_tran_2; pfam12848 1224163002306 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1224163002307 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1224163002308 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1224163002309 Eukaryotic phosphomannomutase; Region: PMM; cl17107 1224163002310 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1224163002311 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1224163002312 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1224163002313 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1224163002314 substrate binding site [chemical binding]; other site 1224163002315 oxyanion hole (OAH) forming residues; other site 1224163002316 trimer interface [polypeptide binding]; other site 1224163002317 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1224163002318 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 1224163002319 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1224163002320 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1224163002321 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 1224163002322 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1224163002323 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1224163002324 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1224163002325 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1224163002326 NAD(P) binding site [chemical binding]; other site 1224163002327 active site 1224163002328 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1224163002329 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1224163002330 active site 1224163002331 nucleophile elbow; other site 1224163002332 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 1224163002333 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1224163002334 G1 box; other site 1224163002335 putative GEF interaction site [polypeptide binding]; other site 1224163002336 GTP/Mg2+ binding site [chemical binding]; other site 1224163002337 Switch I region; other site 1224163002338 G2 box; other site 1224163002339 G3 box; other site 1224163002340 Switch II region; other site 1224163002341 G4 box; other site 1224163002342 G5 box; other site 1224163002343 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1224163002344 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1224163002345 NAD(P) binding site [chemical binding]; other site 1224163002346 active site 1224163002347 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1224163002348 Predicted membrane protein [Function unknown]; Region: COG3212 1224163002349 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1224163002350 Predicted flavoprotein [General function prediction only]; Region: COG0431 1224163002351 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1224163002352 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1224163002353 putative active site [active] 1224163002354 catalytic residue [active] 1224163002355 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1224163002356 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1224163002357 FMN binding site [chemical binding]; other site 1224163002358 substrate binding site [chemical binding]; other site 1224163002359 putative catalytic residue [active] 1224163002360 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1224163002361 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1224163002362 putative NAD(P) binding site [chemical binding]; other site 1224163002363 Anabaena sensory rhodopsin transducer; Region: ASRT; cl01751 1224163002364 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 1224163002365 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1224163002366 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1224163002367 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1224163002368 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 1224163002369 Cupin domain; Region: Cupin_2; pfam07883 1224163002370 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1224163002371 Bacterial transcriptional regulator; Region: IclR; pfam01614 1224163002372 benzoate transport; Region: 2A0115; TIGR00895 1224163002373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163002374 putative substrate translocation pore; other site 1224163002375 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1224163002376 salicylate hydroxylase; Provisional; Region: PRK08163 1224163002377 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1224163002378 putative active site [active] 1224163002379 catalytic residue [active] 1224163002380 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1224163002381 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1224163002382 5S rRNA interface [nucleotide binding]; other site 1224163002383 CTC domain interface [polypeptide binding]; other site 1224163002384 L16 interface [polypeptide binding]; other site 1224163002385 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163002386 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1224163002387 putative substrate translocation pore; other site 1224163002388 potential frameshift: common BLAST hit: gi|340795944|ref|YP_004761407.1| short chain dehydrogenase/reductase family oxidoreductase 1224163002389 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1224163002390 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1224163002391 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1224163002392 active site 1224163002393 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1224163002394 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1224163002395 Substrate binding site; other site 1224163002396 Mg++ binding site; other site 1224163002397 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1224163002398 active site 1224163002399 substrate binding site [chemical binding]; other site 1224163002400 CoA binding site [chemical binding]; other site 1224163002401 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1224163002402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163002403 putative substrate translocation pore; other site 1224163002404 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1224163002405 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1224163002406 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1224163002407 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1224163002408 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1224163002409 catalytic loop [active] 1224163002410 iron binding site [ion binding]; other site 1224163002411 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1224163002412 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1224163002413 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1224163002414 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1224163002415 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1224163002416 ATP binding site [chemical binding]; other site 1224163002417 putative Mg++ binding site [ion binding]; other site 1224163002418 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1224163002419 nucleotide binding region [chemical binding]; other site 1224163002420 ATP-binding site [chemical binding]; other site 1224163002421 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1224163002422 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1224163002423 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1224163002424 ATP binding site [chemical binding]; other site 1224163002425 Mg2+ binding site [ion binding]; other site 1224163002426 G-X-G motif; other site 1224163002427 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1224163002428 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1224163002429 DNA binding residues [nucleotide binding] 1224163002430 dimerization interface [polypeptide binding]; other site 1224163002431 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1224163002432 homodimer interface [polypeptide binding]; other site 1224163002433 metal binding site [ion binding]; metal-binding site 1224163002434 Alpha helical Porin B; Region: PorB; pfam11565 1224163002435 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1224163002436 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1224163002437 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1224163002438 enolase; Provisional; Region: eno; PRK00077 1224163002439 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1224163002440 dimer interface [polypeptide binding]; other site 1224163002441 metal binding site [ion binding]; metal-binding site 1224163002442 substrate binding pocket [chemical binding]; other site 1224163002443 Septum formation initiator; Region: DivIC; pfam04977 1224163002444 Uncharacterized conserved protein [Function unknown]; Region: COG1507 1224163002445 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1224163002446 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1224163002447 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1224163002448 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1224163002449 Walker A/P-loop; other site 1224163002450 ATP binding site [chemical binding]; other site 1224163002451 Q-loop/lid; other site 1224163002452 ABC transporter signature motif; other site 1224163002453 Walker B; other site 1224163002454 D-loop; other site 1224163002455 H-loop/switch region; other site 1224163002456 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1224163002457 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1224163002458 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 1224163002459 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1224163002460 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1224163002461 potential frameshift: common BLAST hit: gi|172040505|ref|YP_001800219.1| dimethyl sulfoxide reductase chain A 1224163002462 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1224163002463 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1224163002464 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1224163002465 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1224163002466 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1224163002467 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1224163002468 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 1224163002469 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1224163002470 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1224163002471 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1224163002472 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1224163002473 catalytic residue [active] 1224163002474 putative FPP diphosphate binding site; other site 1224163002475 putative FPP binding hydrophobic cleft; other site 1224163002476 dimer interface [polypeptide binding]; other site 1224163002477 putative IPP diphosphate binding site; other site 1224163002478 BCCT family transporter; Region: BCCT; pfam02028 1224163002479 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 1224163002480 pantothenate kinase; Provisional; Region: PRK05439 1224163002481 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1224163002482 ATP-binding site [chemical binding]; other site 1224163002483 CoA-binding site [chemical binding]; other site 1224163002484 Mg2+-binding site [ion binding]; other site 1224163002485 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1224163002486 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1224163002487 dimer interface [polypeptide binding]; other site 1224163002488 active site 1224163002489 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1224163002490 folate binding site [chemical binding]; other site 1224163002491 transcriptional regulator BetI; Validated; Region: PRK00767 1224163002492 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1224163002493 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1224163002494 active site 1224163002495 catalytic site [active] 1224163002496 benzoate transport; Region: 2A0115; TIGR00895 1224163002497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163002498 putative substrate translocation pore; other site 1224163002499 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1224163002500 dimerization interface [polypeptide binding]; other site 1224163002501 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1224163002502 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1224163002503 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1224163002504 putative active site [active] 1224163002505 PhoH-like protein; Region: PhoH; pfam02562 1224163002506 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1224163002507 Class II fumarases; Region: Fumarase_classII; cd01362 1224163002508 active site 1224163002509 tetramer interface [polypeptide binding]; other site 1224163002510 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1224163002511 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1224163002512 putative active site [active] 1224163002513 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1224163002514 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1224163002515 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1224163002516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1224163002517 dimer interface [polypeptide binding]; other site 1224163002518 conserved gate region; other site 1224163002519 putative PBP binding loops; other site 1224163002520 ABC-ATPase subunit interface; other site 1224163002521 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1224163002522 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1224163002523 Walker A/P-loop; other site 1224163002524 ATP binding site [chemical binding]; other site 1224163002525 Q-loop/lid; other site 1224163002526 ABC transporter signature motif; other site 1224163002527 Walker B; other site 1224163002528 D-loop; other site 1224163002529 H-loop/switch region; other site 1224163002530 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1224163002531 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1224163002532 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1224163002533 substrate binding pocket [chemical binding]; other site 1224163002534 membrane-bound complex binding site; other site 1224163002535 hinge residues; other site 1224163002536 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1224163002537 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1224163002538 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1224163002539 active site 1224163002540 non-prolyl cis peptide bond; other site 1224163002541 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1224163002542 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1224163002543 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1224163002544 generic binding surface II; other site 1224163002545 generic binding surface I; other site 1224163002546 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700 1224163002547 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1224163002548 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1224163002549 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1224163002550 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1224163002551 GTP-binding protein YchF; Reviewed; Region: PRK09601 1224163002552 YchF GTPase; Region: YchF; cd01900 1224163002553 G1 box; other site 1224163002554 GTP/Mg2+ binding site [chemical binding]; other site 1224163002555 Switch I region; other site 1224163002556 G2 box; other site 1224163002557 Switch II region; other site 1224163002558 G3 box; other site 1224163002559 G4 box; other site 1224163002560 G5 box; other site 1224163002561 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1224163002562 Protein of unknown function (DUF2872); Region: DUF2872; pfam11071 1224163002563 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1224163002564 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1224163002565 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1224163002566 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1224163002567 PAS domain; Region: PAS_9; pfam13426 1224163002568 putative active site [active] 1224163002569 heme pocket [chemical binding]; other site 1224163002570 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1224163002571 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1224163002572 metal binding site [ion binding]; metal-binding site 1224163002573 active site 1224163002574 I-site; other site 1224163002575 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1224163002576 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1224163002577 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1224163002578 DXD motif; other site 1224163002579 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 1224163002580 GIY-YIG motif/motif A; other site 1224163002581 active site 1224163002582 catalytic site [active] 1224163002583 metal binding site [ion binding]; metal-binding site 1224163002584 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1224163002585 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1224163002586 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1224163002587 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1224163002588 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1224163002589 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1224163002590 FMN binding site [chemical binding]; other site 1224163002591 active site 1224163002592 substrate binding site [chemical binding]; other site 1224163002593 catalytic residue [active] 1224163002594 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1224163002595 hydrophobic ligand binding site; other site 1224163002596 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1224163002597 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1224163002598 Protein of unknown function (DUF429); Region: DUF429; cl12046 1224163002599 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1224163002600 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1224163002601 Walker A/P-loop; other site 1224163002602 ATP binding site [chemical binding]; other site 1224163002603 Q-loop/lid; other site 1224163002604 ABC transporter signature motif; other site 1224163002605 Walker B; other site 1224163002606 D-loop; other site 1224163002607 H-loop/switch region; other site 1224163002608 ABC transporter; Region: ABC_tran_2; pfam12848 1224163002609 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1224163002610 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1224163002611 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1224163002612 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1224163002613 dimer interface [polypeptide binding]; other site 1224163002614 conserved gate region; other site 1224163002615 putative PBP binding loops; other site 1224163002616 ABC-ATPase subunit interface; other site 1224163002617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1224163002618 dimer interface [polypeptide binding]; other site 1224163002619 conserved gate region; other site 1224163002620 putative PBP binding loops; other site 1224163002621 ABC-ATPase subunit interface; other site 1224163002622 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1224163002623 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1224163002624 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1224163002625 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1224163002626 Walker A/P-loop; other site 1224163002627 ATP binding site [chemical binding]; other site 1224163002628 Q-loop/lid; other site 1224163002629 ABC transporter signature motif; other site 1224163002630 Walker B; other site 1224163002631 D-loop; other site 1224163002632 H-loop/switch region; other site 1224163002633 TOBE domain; Region: TOBE_2; pfam08402 1224163002634 potential frameshift: common BLAST hit: gi|345016249|ref|YP_004818603.1| transposase IS4 family protein 1224163002635 hypothetical protein; Provisional; Region: PRK09256 1224163002636 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 1224163002637 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1224163002638 metal ion-dependent adhesion site (MIDAS); other site 1224163002639 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 1224163002640 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1224163002641 catalytic core [active] 1224163002642 conserved hypothetical protein; Region: TIGR03843 1224163002643 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1224163002644 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1224163002645 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1224163002646 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1224163002647 catalytic loop [active] 1224163002648 iron binding site [ion binding]; other site 1224163002649 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1224163002650 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1224163002651 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1224163002652 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1224163002653 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1224163002654 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1224163002655 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1224163002656 metal-binding site 1224163002657 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1224163002658 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1224163002659 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1224163002660 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1224163002661 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1224163002662 A-kinase anchor protein 110 kDa (AKAP 110); Region: AKAP_110; cl14906 1224163002663 Protein of unknown function, DUF488; Region: DUF488; pfam04343 1224163002664 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 1224163002665 Phosphotransferase enzyme family; Region: APH; pfam01636 1224163002666 putative active site [active] 1224163002667 putative substrate binding site [chemical binding]; other site 1224163002668 ATP binding site [chemical binding]; other site 1224163002669 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1224163002670 E-class dimer interface [polypeptide binding]; other site 1224163002671 P-class dimer interface [polypeptide binding]; other site 1224163002672 active site 1224163002673 Cu2+ binding site [ion binding]; other site 1224163002674 Zn2+ binding site [ion binding]; other site 1224163002675 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 1224163002676 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 1224163002677 putative catalytic site [active] 1224163002678 putative metal binding site [ion binding]; other site 1224163002679 putative phosphate binding site [ion binding]; other site 1224163002680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163002681 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1224163002682 putative substrate translocation pore; other site 1224163002683 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1224163002684 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1224163002685 Thymidine kinase [Nucleotide transport and metabolism]; Region: Tdk; COG1435 1224163002686 short chain dehydrogenase; Provisional; Region: PRK06197 1224163002687 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1224163002688 NAD(P) binding site [chemical binding]; other site 1224163002689 active site 1224163002690 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1224163002691 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 1224163002692 gating phenylalanine in ion channel; other site 1224163002693 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1224163002694 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1224163002695 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1224163002696 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1224163002697 DNA-binding site [nucleotide binding]; DNA binding site 1224163002698 UTRA domain; Region: UTRA; cl17743 1224163002699 MMPL family; Region: MMPL; pfam03176 1224163002700 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1224163002701 MarR family; Region: MarR; pfam01047 1224163002702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1224163002703 S-adenosylmethionine binding site [chemical binding]; other site 1224163002704 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1224163002705 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1224163002706 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1224163002707 putative ADP-ribose binding site [chemical binding]; other site 1224163002708 putative active site [active] 1224163002709 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1224163002710 active site 1224163002711 metal binding site [ion binding]; metal-binding site 1224163002712 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1224163002713 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1224163002714 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1224163002715 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1224163002716 active site 1224163002717 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1224163002718 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1224163002719 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1224163002720 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1224163002721 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1224163002722 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163002723 D-galactonate transporter; Region: 2A0114; TIGR00893 1224163002724 putative substrate translocation pore; other site 1224163002725 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1224163002726 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1224163002727 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1224163002728 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1224163002729 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1224163002730 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1224163002731 molybdopterin cofactor binding site; other site 1224163002732 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 1224163002733 4Fe-4S binding domain; Region: Fer4; cl02805 1224163002734 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1224163002735 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1224163002736 hypothetical protein; Provisional; Region: PRK06847 1224163002737 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1224163002738 active site 1224163002739 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: Php; COG1735 1224163002740 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1224163002741 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1224163002742 DNA-binding site [nucleotide binding]; DNA binding site 1224163002743 UTRA domain; Region: UTRA; pfam07702 1224163002744 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1224163002745 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1224163002746 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1224163002747 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1224163002748 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1224163002749 molybdopterin cofactor binding site; other site 1224163002750 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 1224163002751 4Fe-4S binding domain; Region: Fer4; cl02805 1224163002752 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1224163002753 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 1224163002754 potential frameshift: common BLAST hit: gi|320106326|ref|YP_004181916.1| NAD-dependent epimerase/dehydratase 1224163002755 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1224163002756 selenium donor protein; Region: selD; TIGR00476 1224163002757 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1224163002758 dimerization interface [polypeptide binding]; other site 1224163002759 putative ATP binding site [chemical binding]; other site 1224163002760 selenocysteine synthase; Provisional; Region: PRK04311 1224163002761 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1224163002762 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 1224163002763 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1224163002764 G1 box; other site 1224163002765 putative GEF interaction site [polypeptide binding]; other site 1224163002766 GTP/Mg2+ binding site [chemical binding]; other site 1224163002767 Switch I region; other site 1224163002768 G2 box; other site 1224163002769 G3 box; other site 1224163002770 Switch II region; other site 1224163002771 G4 box; other site 1224163002772 G5 box; other site 1224163002773 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1224163002774 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1224163002775 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1224163002776 active site 1224163002777 SUMO-1 interface [polypeptide binding]; other site 1224163002778 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1224163002779 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1224163002780 Domain of unknown function DUF21; Region: DUF21; pfam01595 1224163002781 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1224163002782 Transporter associated domain; Region: CorC_HlyC; smart01091 1224163002783 zinc transporter ZupT; Provisional; Region: PRK04201 1224163002784 Protein of unknown function (DUF808); Region: DUF808; cl01002 1224163002785 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1224163002786 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1224163002787 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1224163002788 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424 1224163002789 thiamine pyrophosphate protein; Provisional; Region: PRK08273 1224163002790 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1224163002791 PYR/PP interface [polypeptide binding]; other site 1224163002792 dimer interface [polypeptide binding]; other site 1224163002793 tetramer interface [polypeptide binding]; other site 1224163002794 TPP binding site [chemical binding]; other site 1224163002795 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1224163002796 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1224163002797 TPP-binding site [chemical binding]; other site 1224163002798 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1224163002799 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1224163002800 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1224163002801 iron-sulfur cluster [ion binding]; other site 1224163002802 [2Fe-2S] cluster binding site [ion binding]; other site 1224163002803 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1224163002804 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1224163002805 NAD binding site [chemical binding]; other site 1224163002806 catalytic Zn binding site [ion binding]; other site 1224163002807 structural Zn binding site [ion binding]; other site 1224163002808 Competence-damaged protein; Region: CinA; pfam02464 1224163002809 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1224163002810 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1224163002811 NAD(P) binding site [chemical binding]; other site 1224163002812 active site 1224163002813 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 1224163002814 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1224163002815 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1224163002816 Walker A/P-loop; other site 1224163002817 ATP binding site [chemical binding]; other site 1224163002818 Q-loop/lid; other site 1224163002819 ABC transporter signature motif; other site 1224163002820 Walker B; other site 1224163002821 D-loop; other site 1224163002822 H-loop/switch region; other site 1224163002823 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1224163002824 Walker A/P-loop; other site 1224163002825 ATP binding site [chemical binding]; other site 1224163002826 Q-loop/lid; other site 1224163002827 ABC transporter signature motif; other site 1224163002828 Walker B; other site 1224163002829 D-loop; other site 1224163002830 H-loop/switch region; other site 1224163002831 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1224163002832 hypothetical protein; Provisional; Region: PRK06547 1224163002833 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1224163002834 active site 1224163002835 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1224163002836 ArsC family; Region: ArsC; pfam03960 1224163002837 catalytic residues [active] 1224163002838 Protein of unknown function (DUF402); Region: DUF402; cl00979 1224163002839 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1224163002840 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1224163002841 G1 box; other site 1224163002842 putative GEF interaction site [polypeptide binding]; other site 1224163002843 GTP/Mg2+ binding site [chemical binding]; other site 1224163002844 Switch I region; other site 1224163002845 G2 box; other site 1224163002846 G3 box; other site 1224163002847 Switch II region; other site 1224163002848 G4 box; other site 1224163002849 G5 box; other site 1224163002850 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1224163002851 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1224163002852 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1224163002853 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1224163002854 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1224163002855 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1224163002856 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1224163002857 Ferredoxin [Energy production and conversion]; Region: COG1146 1224163002858 4Fe-4S binding domain; Region: Fer4; pfam00037 1224163002859 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1224163002860 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1224163002861 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1224163002862 homodimer interface [polypeptide binding]; other site 1224163002863 catalytic residue [active] 1224163002864 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1224163002865 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1224163002866 active site 1224163002867 Predicted membrane protein [Function unknown]; Region: COG2246 1224163002868 GtrA-like protein; Region: GtrA; pfam04138 1224163002869 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1224163002870 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1224163002871 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1224163002872 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1224163002873 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1224163002874 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1224163002875 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1224163002876 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1224163002877 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1224163002878 putative trimer interface [polypeptide binding]; other site 1224163002879 putative CoA binding site [chemical binding]; other site 1224163002880 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1224163002881 dihydropteroate synthase; Region: DHPS; TIGR01496 1224163002882 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1224163002883 substrate binding pocket [chemical binding]; other site 1224163002884 dimer interface [polypeptide binding]; other site 1224163002885 inhibitor binding site; inhibition site 1224163002886 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1224163002887 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1224163002888 active site 1224163002889 DivIVA domain; Region: DivI1A_domain; TIGR03544 1224163002890 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1224163002891 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1224163002892 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1224163002893 S-adenosylmethionine binding site [chemical binding]; other site 1224163002894 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1224163002895 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1224163002896 active site 1224163002897 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1224163002898 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1224163002899 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1224163002900 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1224163002901 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1224163002902 ligand binding site; other site 1224163002903 oligomer interface; other site 1224163002904 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1224163002905 dimer interface [polypeptide binding]; other site 1224163002906 N-terminal domain interface [polypeptide binding]; other site 1224163002907 sulfate 1 binding site; other site 1224163002908 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1224163002909 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1224163002910 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 1224163002911 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1224163002912 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1224163002913 DNA binding residues [nucleotide binding] 1224163002914 sec-independent translocase; Provisional; Region: tatB; PRK00182 1224163002915 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1224163002916 Domain of unknown function DUF59; Region: DUF59; pfam01883 1224163002917 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1224163002918 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1224163002919 Predicted membrane protein [Function unknown]; Region: COG4420 1224163002920 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1224163002921 MgtE intracellular N domain; Region: MgtE_N; smart00924 1224163002922 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1224163002923 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1224163002924 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1224163002925 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1224163002926 TPP-binding site [chemical binding]; other site 1224163002927 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1224163002928 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1224163002929 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1224163002930 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1224163002931 Walker A/P-loop; other site 1224163002932 ATP binding site [chemical binding]; other site 1224163002933 Q-loop/lid; other site 1224163002934 ABC transporter signature motif; other site 1224163002935 Walker B; other site 1224163002936 D-loop; other site 1224163002937 H-loop/switch region; other site 1224163002938 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1224163002939 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1224163002940 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1224163002941 Walker A/P-loop; other site 1224163002942 ATP binding site [chemical binding]; other site 1224163002943 Q-loop/lid; other site 1224163002944 ABC transporter signature motif; other site 1224163002945 Walker B; other site 1224163002946 D-loop; other site 1224163002947 H-loop/switch region; other site 1224163002948 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1224163002949 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1224163002950 substrate binding pocket [chemical binding]; other site 1224163002951 catalytic triad [active] 1224163002952 Sensors of blue-light using FAD; Region: BLUF; pfam04940 1224163002953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163002954 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1224163002955 putative substrate translocation pore; other site 1224163002956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163002957 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1224163002958 putative substrate translocation pore; other site 1224163002959 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1224163002960 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1224163002961 Inosine-uridine nucleoside N-ribohydrolase [Nucleotide transport and metabolism]; Region: URH1; COG1957 1224163002962 active site 1224163002963 Cobalt transport protein; Region: CbiQ; cl00463 1224163002964 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1224163002965 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1224163002966 Walker A/P-loop; other site 1224163002967 ATP binding site [chemical binding]; other site 1224163002968 ABC transporter signature motif; other site 1224163002969 Walker B; other site 1224163002970 D-loop; other site 1224163002971 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1224163002972 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1224163002973 Walker A/P-loop; other site 1224163002974 ATP binding site [chemical binding]; other site 1224163002975 Q-loop/lid; other site 1224163002976 Walker B; other site 1224163002977 D-loop; other site 1224163002978 H-loop/switch region; other site 1224163002979 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 1224163002980 PLD-like domain; Region: PLDc_2; pfam13091 1224163002981 putative homodimer interface [polypeptide binding]; other site 1224163002982 putative active site [active] 1224163002983 catalytic site [active] 1224163002984 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1224163002985 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1224163002986 putative Mg++ binding site [ion binding]; other site 1224163002987 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1224163002988 nucleotide binding region [chemical binding]; other site 1224163002989 ATP-binding site [chemical binding]; other site 1224163002990 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1224163002991 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1224163002992 active site 1224163002993 8-oxo-dGMP binding site [chemical binding]; other site 1224163002994 nudix motif; other site 1224163002995 metal binding site [ion binding]; metal-binding site 1224163002996 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 1224163002997 putative active site [active] 1224163002998 putative metal binding site [ion binding]; other site 1224163002999 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1224163003000 homotrimer interaction site [polypeptide binding]; other site 1224163003001 putative active site [active] 1224163003002 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1224163003003 helicase 45; Provisional; Region: PTZ00424 1224163003004 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1224163003005 ATP binding site [chemical binding]; other site 1224163003006 Mg++ binding site [ion binding]; other site 1224163003007 motif III; other site 1224163003008 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1224163003009 nucleotide binding region [chemical binding]; other site 1224163003010 ATP-binding site [chemical binding]; other site 1224163003011 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1224163003012 putative RNA binding site [nucleotide binding]; other site 1224163003013 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1224163003014 Coenzyme A binding pocket [chemical binding]; other site 1224163003015 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1224163003016 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1224163003017 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1224163003018 motif II; other site 1224163003019 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 1224163003020 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1224163003021 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1224163003022 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1224163003023 Na binding site [ion binding]; other site 1224163003024 SNF2 Helicase protein; Region: DUF3670; pfam12419 1224163003025 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1224163003026 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1224163003027 ATP binding site [chemical binding]; other site 1224163003028 putative Mg++ binding site [ion binding]; other site 1224163003029 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1224163003030 nucleotide binding region [chemical binding]; other site 1224163003031 ATP-binding site [chemical binding]; other site 1224163003032 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1224163003033 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1224163003034 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1224163003035 active site 1224163003036 metal binding site [ion binding]; metal-binding site 1224163003037 DNA binding site [nucleotide binding] 1224163003038 AAA domain; Region: AAA_23; pfam13476 1224163003039 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1224163003040 Walker A/P-loop; other site 1224163003041 ATP binding site [chemical binding]; other site 1224163003042 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1224163003043 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1224163003044 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1224163003045 PspC domain; Region: PspC; pfam04024 1224163003046 TAP-like protein; Region: Abhydrolase_4; pfam08386 1224163003047 DNA photolyase; Region: DNA_photolyase; pfam00875 1224163003048 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1224163003049 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1224163003050 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1224163003051 NAD(P) binding site [chemical binding]; other site 1224163003052 active site 1224163003053 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1224163003054 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1224163003055 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1224163003056 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1224163003057 active site 1224163003058 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1224163003059 substrate binding pocket [chemical binding]; other site 1224163003060 substrate-Mg2+ binding site; other site 1224163003061 aspartate-rich region 1; other site 1224163003062 aspartate-rich region 2; other site 1224163003063 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1224163003064 active site lid residues [active] 1224163003065 substrate binding pocket [chemical binding]; other site 1224163003066 catalytic residues [active] 1224163003067 substrate-Mg2+ binding site; other site 1224163003068 aspartate-rich region 1; other site 1224163003069 aspartate-rich region 2; other site 1224163003070 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1224163003071 phytoene desaturase; Region: crtI_fam; TIGR02734 1224163003072 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1224163003073 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1224163003074 prenyltransferase; Reviewed; Region: ubiA; PRK13105 1224163003075 UbiA prenyltransferase family; Region: UbiA; pfam01040 1224163003076 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1224163003077 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1224163003078 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1224163003079 active site 1224163003080 HIGH motif; other site 1224163003081 KMSK motif region; other site 1224163003082 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1224163003083 anticodon binding site; other site 1224163003084 tRNA binding surface [nucleotide binding]; other site 1224163003085 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1224163003086 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1224163003087 active site 1224163003088 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1224163003089 substrate binding site [chemical binding]; other site 1224163003090 catalytic residues [active] 1224163003091 dimer interface [polypeptide binding]; other site 1224163003092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163003093 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1224163003094 putative substrate translocation pore; other site 1224163003095 Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Region: SLC5sbd_DUR3; cd11476 1224163003096 Na binding site [ion binding]; other site 1224163003097 homoserine dehydrogenase; Provisional; Region: PRK06349 1224163003098 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1224163003099 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1224163003100 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1224163003101 homoserine kinase; Provisional; Region: PRK01212 1224163003102 Predicted transcriptional regulator [Transcription]; Region: COG2345 1224163003103 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1224163003104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1224163003105 putative PBP binding loops; other site 1224163003106 ABC-ATPase subunit interface; other site 1224163003107 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1224163003108 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1224163003109 Walker A/P-loop; other site 1224163003110 ATP binding site [chemical binding]; other site 1224163003111 Q-loop/lid; other site 1224163003112 ABC transporter signature motif; other site 1224163003113 Walker B; other site 1224163003114 D-loop; other site 1224163003115 H-loop/switch region; other site 1224163003116 TOBE domain; Region: TOBE; cl01440 1224163003117 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1224163003118 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1224163003119 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1224163003120 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1224163003121 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1224163003122 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1224163003123 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1224163003124 [4Fe-4S] binding site [ion binding]; other site 1224163003125 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1224163003126 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1224163003127 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1224163003128 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1224163003129 molybdopterin cofactor binding site; other site 1224163003130 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1224163003131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163003132 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1224163003133 MPT binding site; other site 1224163003134 trimer interface [polypeptide binding]; other site 1224163003135 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1224163003136 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 1224163003137 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1224163003138 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1224163003139 GTP binding site; other site 1224163003140 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 1224163003141 trimer interface [polypeptide binding]; other site 1224163003142 dimer interface [polypeptide binding]; other site 1224163003143 putative active site [active] 1224163003144 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1224163003145 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1224163003146 dimer interface [polypeptide binding]; other site 1224163003147 putative functional site; other site 1224163003148 putative MPT binding site; other site 1224163003149 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1224163003150 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1224163003151 FeS/SAM binding site; other site 1224163003152 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1224163003153 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620 1224163003154 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1224163003155 acyl-activating enzyme (AAE) consensus motif; other site 1224163003156 AMP binding site [chemical binding]; other site 1224163003157 active site 1224163003158 CoA binding site [chemical binding]; other site 1224163003159 transcription termination factor Rho; Provisional; Region: PRK12678 1224163003160 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1224163003161 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1224163003162 RNA binding site [nucleotide binding]; other site 1224163003163 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1224163003164 multimer interface [polypeptide binding]; other site 1224163003165 Walker A motif; other site 1224163003166 ATP binding site [chemical binding]; other site 1224163003167 Walker B motif; other site 1224163003168 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1224163003169 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1224163003170 RF-1 domain; Region: RF-1; pfam00472 1224163003171 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1224163003172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1224163003173 S-adenosylmethionine binding site [chemical binding]; other site 1224163003174 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1224163003175 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1224163003176 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1224163003177 Mg++ binding site [ion binding]; other site 1224163003178 putative catalytic motif [active] 1224163003179 substrate binding site [chemical binding]; other site 1224163003180 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1224163003181 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1224163003182 F0F1 ATP synthase subunit C; Validated; Region: PRK07874 1224163003183 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1224163003184 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1224163003185 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1224163003186 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1224163003187 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1224163003188 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1224163003189 beta subunit interaction interface [polypeptide binding]; other site 1224163003190 Walker A motif; other site 1224163003191 ATP binding site [chemical binding]; other site 1224163003192 Walker B motif; other site 1224163003193 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1224163003194 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1224163003195 core domain interface [polypeptide binding]; other site 1224163003196 delta subunit interface [polypeptide binding]; other site 1224163003197 epsilon subunit interface [polypeptide binding]; other site 1224163003198 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1224163003199 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1224163003200 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1224163003201 alpha subunit interaction interface [polypeptide binding]; other site 1224163003202 Walker A motif; other site 1224163003203 ATP binding site [chemical binding]; other site 1224163003204 Walker B motif; other site 1224163003205 inhibitor binding site; inhibition site 1224163003206 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1224163003207 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1224163003208 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1224163003209 gamma subunit interface [polypeptide binding]; other site 1224163003210 epsilon subunit interface [polypeptide binding]; other site 1224163003211 LBP interface [polypeptide binding]; other site 1224163003212 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1224163003213 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1224163003214 hypothetical protein; Provisional; Region: PRK03298 1224163003215 Domain of unknown function DUF77; Region: DUF77; pfam01910 1224163003216 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1224163003217 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1224163003218 glycogen branching enzyme; Provisional; Region: PRK05402 1224163003219 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1224163003220 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1224163003221 active site 1224163003222 catalytic site [active] 1224163003223 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1224163003224 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1224163003225 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1224163003226 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1224163003227 active site 1224163003228 catalytic site [active] 1224163003229 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1224163003230 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1224163003231 Walker A/P-loop; other site 1224163003232 ATP binding site [chemical binding]; other site 1224163003233 ABC transporter signature motif; other site 1224163003234 Walker B; other site 1224163003235 D-loop; other site 1224163003236 H-loop/switch region; other site 1224163003237 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1224163003238 nudix motif; other site 1224163003239 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1224163003240 Ligand binding site [chemical binding]; other site 1224163003241 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1224163003242 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1224163003243 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1224163003244 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1224163003245 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1224163003246 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1224163003247 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1224163003248 catalytic residue [active] 1224163003249 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1224163003250 S-adenosylmethionine binding site [chemical binding]; other site 1224163003251 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1224163003252 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1224163003253 Ligand Binding Site [chemical binding]; other site 1224163003254 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1224163003255 Beta-lactamase; Region: Beta-lactamase; pfam00144 1224163003256 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1224163003257 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1224163003258 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1224163003259 active site 1224163003260 catalytic site [active] 1224163003261 substrate binding site [chemical binding]; other site 1224163003262 Putative esterase; Region: Esterase; pfam00756 1224163003263 Predicted esterase [General function prediction only]; Region: COG0627 1224163003264 Predicted esterase [General function prediction only]; Region: COG0627 1224163003265 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1224163003266 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1224163003267 nucleotide binding pocket [chemical binding]; other site 1224163003268 K-X-D-G motif; other site 1224163003269 catalytic site [active] 1224163003270 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1224163003271 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1224163003272 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1224163003273 Dimer interface [polypeptide binding]; other site 1224163003274 BRCT sequence motif; other site 1224163003275 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1224163003276 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1224163003277 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1224163003278 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1224163003279 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1224163003280 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1224163003281 ABC transporter signature motif; other site 1224163003282 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1224163003283 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1224163003284 FAD binding pocket [chemical binding]; other site 1224163003285 FAD binding motif [chemical binding]; other site 1224163003286 phosphate binding motif [ion binding]; other site 1224163003287 NAD binding pocket [chemical binding]; other site 1224163003288 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1224163003289 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1224163003290 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1224163003291 active site 1224163003292 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1224163003293 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1224163003294 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1224163003295 putative ADP-binding pocket [chemical binding]; other site 1224163003296 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 1224163003297 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1224163003298 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1224163003299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163003300 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1224163003301 putative substrate translocation pore; other site 1224163003302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163003303 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1224163003304 phosphofructokinase; Region: PFK_mixed; TIGR02483 1224163003305 active site 1224163003306 ADP/pyrophosphate binding site [chemical binding]; other site 1224163003307 dimerization interface [polypeptide binding]; other site 1224163003308 allosteric effector site; other site 1224163003309 fructose-1,6-bisphosphate binding site; other site 1224163003310 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1224163003311 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1224163003312 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1224163003313 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1224163003314 GatB domain; Region: GatB_Yqey; smart00845 1224163003315 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1224163003316 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1224163003317 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1224163003318 active site 1224163003319 catalytic tetrad [active] 1224163003320 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1224163003321 MarR family; Region: MarR_2; pfam12802 1224163003322 MarR family; Region: MarR_2; cl17246 1224163003323 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1224163003324 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1224163003325 active site 1224163003326 catalytic tetrad [active] 1224163003327 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1224163003328 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1224163003329 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1224163003330 putative dimer interface [polypeptide binding]; other site 1224163003331 N-terminal domain interface [polypeptide binding]; other site 1224163003332 putative substrate binding pocket (H-site) [chemical binding]; other site 1224163003333 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1224163003334 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1224163003335 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1224163003336 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1224163003337 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1224163003338 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1224163003339 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1224163003340 PYR/PP interface [polypeptide binding]; other site 1224163003341 dimer interface [polypeptide binding]; other site 1224163003342 TPP binding site [chemical binding]; other site 1224163003343 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1224163003344 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1224163003345 TPP-binding site [chemical binding]; other site 1224163003346 dimer interface [polypeptide binding]; other site 1224163003347 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1224163003348 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1224163003349 putative valine binding site [chemical binding]; other site 1224163003350 dimer interface [polypeptide binding]; other site 1224163003351 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1224163003352 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1224163003353 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1224163003354 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1224163003355 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1224163003356 Protein of unknown function DUF262; Region: DUF262; pfam03235 1224163003357 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1224163003358 Uncharacterized conserved protein [Function unknown]; Region: COG3472 1224163003359 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1224163003360 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1224163003361 ligand binding site [chemical binding]; other site 1224163003362 NAD binding site [chemical binding]; other site 1224163003363 dimerization interface [polypeptide binding]; other site 1224163003364 catalytic site [active] 1224163003365 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1224163003366 putative L-serine binding site [chemical binding]; other site 1224163003367 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1224163003368 tartrate dehydrogenase; Region: TTC; TIGR02089 1224163003369 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 1224163003370 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1224163003371 ligand binding site [chemical binding]; other site 1224163003372 flexible hinge region; other site 1224163003373 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 1224163003374 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1224163003375 metal binding triad; other site 1224163003376 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1224163003377 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1224163003378 active site 1224163003379 catalytic site [active] 1224163003380 substrate binding site [chemical binding]; other site 1224163003381 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1224163003382 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1224163003383 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1224163003384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1224163003385 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1224163003386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1224163003387 S-adenosylmethionine binding site [chemical binding]; other site 1224163003388 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1224163003389 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1224163003390 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1224163003391 active site 1224163003392 HIGH motif; other site 1224163003393 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1224163003394 active site 1224163003395 KMSKS motif; other site 1224163003396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163003397 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1224163003398 putative substrate translocation pore; other site 1224163003399 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1224163003400 dimerization interface [polypeptide binding]; other site 1224163003401 putative DNA binding site [nucleotide binding]; other site 1224163003402 putative Zn2+ binding site [ion binding]; other site 1224163003403 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1224163003404 active site residue [active] 1224163003405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1224163003406 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1224163003407 nucleoside/Zn binding site; other site 1224163003408 dimer interface [polypeptide binding]; other site 1224163003409 catalytic motif [active] 1224163003410 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1224163003411 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1224163003412 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1224163003413 putative DNA binding site [nucleotide binding]; other site 1224163003414 putative Zn2+ binding site [ion binding]; other site 1224163003415 Bacterial transcriptional regulator; Region: IclR; pfam01614 1224163003416 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1224163003417 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1224163003418 substrate binding site [chemical binding]; other site 1224163003419 ligand binding site [chemical binding]; other site 1224163003420 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1224163003421 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1224163003422 substrate binding site [chemical binding]; other site 1224163003423 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1224163003424 active site 1224163003425 Ap6A binding site [chemical binding]; other site 1224163003426 nudix motif; other site 1224163003427 metal binding site [ion binding]; metal-binding site 1224163003428 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1224163003429 catalytic core [active] 1224163003430 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1224163003431 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1224163003432 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1224163003433 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1224163003434 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1224163003435 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1224163003436 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1224163003437 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1224163003438 thiamine monophosphate kinase; Provisional; Region: PRK05731 1224163003439 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1224163003440 ATP binding site [chemical binding]; other site 1224163003441 dimerization interface [polypeptide binding]; other site 1224163003442 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1224163003443 ligand binding site [chemical binding]; other site 1224163003444 active site 1224163003445 UGI interface [polypeptide binding]; other site 1224163003446 catalytic site [active] 1224163003447 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1224163003448 DAK2 domain; Region: Dak2; pfam02734 1224163003449 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1224163003450 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1224163003451 ssDNA binding site; other site 1224163003452 generic binding surface II; other site 1224163003453 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1224163003454 ATP binding site [chemical binding]; other site 1224163003455 putative Mg++ binding site [ion binding]; other site 1224163003456 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1224163003457 nucleotide binding region [chemical binding]; other site 1224163003458 ATP-binding site [chemical binding]; other site 1224163003459 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1224163003460 carboxyltransferase (CT) interaction site; other site 1224163003461 biotinylation site [posttranslational modification]; other site 1224163003462 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1224163003463 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1224163003464 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1224163003465 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1224163003466 active site 1224163003467 (T/H)XGH motif; other site 1224163003468 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1224163003469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 1224163003470 SnoaL-like domain; Region: SnoaL_2; pfam12680 1224163003471 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1224163003472 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1224163003473 Walker A/P-loop; other site 1224163003474 ATP binding site [chemical binding]; other site 1224163003475 Q-loop/lid; other site 1224163003476 ABC transporter signature motif; other site 1224163003477 Walker B; other site 1224163003478 D-loop; other site 1224163003479 H-loop/switch region; other site 1224163003480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1224163003481 dimer interface [polypeptide binding]; other site 1224163003482 conserved gate region; other site 1224163003483 putative PBP binding loops; other site 1224163003484 ABC-ATPase subunit interface; other site 1224163003485 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1224163003486 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1224163003487 substrate binding pocket [chemical binding]; other site 1224163003488 membrane-bound complex binding site; other site 1224163003489 hinge residues; other site 1224163003490 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1224163003491 active site 1224163003492 catalytic triad [active] 1224163003493 oxyanion hole [active] 1224163003494 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1224163003495 active site 1224163003496 catalytic triad [active] 1224163003497 oxyanion hole [active] 1224163003498 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1224163003499 active site 1224163003500 catalytic triad [active] 1224163003501 oxyanion hole [active] 1224163003502 Domain of unknown function (DUF368); Region: DUF368; pfam04018 1224163003503 DNA polymerase I; Provisional; Region: PRK05755 1224163003504 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1224163003505 active site 1224163003506 putative 5' ssDNA interaction site; other site 1224163003507 metal binding site 3; metal-binding site 1224163003508 metal binding site 1 [ion binding]; metal-binding site 1224163003509 metal binding site 2 [ion binding]; metal-binding site 1224163003510 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1224163003511 putative DNA binding site [nucleotide binding]; other site 1224163003512 putative metal binding site [ion binding]; other site 1224163003513 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1224163003514 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1224163003515 active site 1224163003516 DNA binding site [nucleotide binding] 1224163003517 catalytic site [active] 1224163003518 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 1224163003519 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1224163003520 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1224163003521 NAD(P) binding site [chemical binding]; other site 1224163003522 catalytic residues [active] 1224163003523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1224163003524 S-adenosylmethionine binding site [chemical binding]; other site 1224163003525 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1224163003526 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1224163003527 RNA binding site [nucleotide binding]; other site 1224163003528 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1224163003529 RNA binding site [nucleotide binding]; other site 1224163003530 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1224163003531 RNA binding site [nucleotide binding]; other site 1224163003532 S1 RNA binding domain; Region: S1; pfam00575 1224163003533 RNA binding site [nucleotide binding]; other site 1224163003534 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 1224163003535 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1224163003536 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1224163003537 CoA-binding site [chemical binding]; other site 1224163003538 ATP-binding [chemical binding]; other site 1224163003539 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 1224163003540 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 1224163003541 Catalytic site; other site 1224163003542 Staphylococcal nuclease homologue; Region: SNase; pfam00565 1224163003543 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1224163003544 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 1224163003545 excinuclease ABC subunit B; Provisional; Region: PRK05298 1224163003546 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1224163003547 ATP binding site [chemical binding]; other site 1224163003548 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1224163003549 nucleotide binding region [chemical binding]; other site 1224163003550 ATP-binding site [chemical binding]; other site 1224163003551 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1224163003552 UvrB/uvrC motif; Region: UVR; pfam02151 1224163003553 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1224163003554 Ligand Binding Site [chemical binding]; other site 1224163003555 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1224163003556 Ligand Binding Site [chemical binding]; other site 1224163003557 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1224163003558 Part of AAA domain; Region: AAA_19; pfam13245 1224163003559 Family description; Region: UvrD_C_2; pfam13538 1224163003560 Predicted membrane protein [Function unknown]; Region: COG2259 1224163003561 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1224163003562 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1224163003563 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1224163003564 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1224163003565 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1224163003566 translation initiation factor IF-3; Region: infC; TIGR00168 1224163003567 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1224163003568 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1224163003569 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1224163003570 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1224163003571 23S rRNA binding site [nucleotide binding]; other site 1224163003572 L21 binding site [polypeptide binding]; other site 1224163003573 L13 binding site [polypeptide binding]; other site 1224163003574 Proline dehydrogenase; Region: Pro_dh; cl03282 1224163003575 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1224163003576 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1224163003577 NAD(P) binding site [chemical binding]; other site 1224163003578 catalytic residues [active] 1224163003579 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1224163003580 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1224163003581 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1224163003582 YtpI-like protein; Region: YtpI; pfam14007 1224163003583 TM2 domain; Region: TM2; pfam05154 1224163003584 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1224163003585 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1224163003586 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1224163003587 dimer interface [polypeptide binding]; other site 1224163003588 motif 1; other site 1224163003589 active site 1224163003590 motif 2; other site 1224163003591 motif 3; other site 1224163003592 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1224163003593 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1224163003594 putative tRNA-binding site [nucleotide binding]; other site 1224163003595 B3/4 domain; Region: B3_4; pfam03483 1224163003596 tRNA synthetase B5 domain; Region: B5; smart00874 1224163003597 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1224163003598 dimer interface [polypeptide binding]; other site 1224163003599 motif 1; other site 1224163003600 motif 3; other site 1224163003601 motif 2; other site 1224163003602 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1224163003603 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1224163003604 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1224163003605 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1224163003606 heterotetramer interface [polypeptide binding]; other site 1224163003607 active site pocket [active] 1224163003608 cleavage site 1224163003609 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1224163003610 feedback inhibition sensing region; other site 1224163003611 homohexameric interface [polypeptide binding]; other site 1224163003612 nucleotide binding site [chemical binding]; other site 1224163003613 N-acetyl-L-glutamate binding site [chemical binding]; other site 1224163003614 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1224163003615 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1224163003616 inhibitor-cofactor binding pocket; inhibition site 1224163003617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1224163003618 catalytic residue [active] 1224163003619 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1224163003620 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1224163003621 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1224163003622 arginine repressor; Provisional; Region: PRK03341 1224163003623 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1224163003624 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1224163003625 argininosuccinate synthase; Provisional; Region: PRK13820 1224163003626 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1224163003627 ANP binding site [chemical binding]; other site 1224163003628 Substrate Binding Site II [chemical binding]; other site 1224163003629 Substrate Binding Site I [chemical binding]; other site 1224163003630 argininosuccinate lyase; Provisional; Region: PRK00855 1224163003631 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1224163003632 active sites [active] 1224163003633 tetramer interface [polypeptide binding]; other site 1224163003634 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1224163003635 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1224163003636 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1224163003637 active site 1224163003638 HIGH motif; other site 1224163003639 dimer interface [polypeptide binding]; other site 1224163003640 KMSKS motif; other site 1224163003641 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1224163003642 RNA binding surface [nucleotide binding]; other site 1224163003643 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1224163003644 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1224163003645 motif II; other site 1224163003646 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1224163003647 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1224163003648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1224163003649 S-adenosylmethionine binding site [chemical binding]; other site 1224163003650 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1224163003651 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1224163003652 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1224163003653 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1224163003654 Walker A/P-loop; other site 1224163003655 ATP binding site [chemical binding]; other site 1224163003656 Q-loop/lid; other site 1224163003657 ABC transporter signature motif; other site 1224163003658 Walker B; other site 1224163003659 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1224163003660 ABC transporter signature motif; other site 1224163003661 Walker B; other site 1224163003662 D-loop; other site 1224163003663 H-loop/switch region; other site 1224163003664 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1224163003665 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 1224163003666 Thiamine pyrophosphokinase; Region: TPK; cl08415 1224163003667 active site 1224163003668 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1224163003669 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1224163003670 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1224163003671 dimer interface [polypeptide binding]; other site 1224163003672 ADP-ribose binding site [chemical binding]; other site 1224163003673 active site 1224163003674 nudix motif; other site 1224163003675 metal binding site [ion binding]; metal-binding site 1224163003676 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1224163003677 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1224163003678 active site 1224163003679 Int/Topo IB signature motif; other site 1224163003680 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1224163003681 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1224163003682 P-loop; other site 1224163003683 Magnesium ion binding site [ion binding]; other site 1224163003684 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1224163003685 Magnesium ion binding site [ion binding]; other site 1224163003686 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1224163003687 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1224163003688 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1224163003689 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1224163003690 RNA binding surface [nucleotide binding]; other site 1224163003691 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1224163003692 active site 1224163003693 cytidylate kinase; Provisional; Region: cmk; PRK00023 1224163003694 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1224163003695 CMP-binding site; other site 1224163003696 The sites determining sugar specificity; other site 1224163003697 GTP-binding protein Der; Reviewed; Region: PRK03003 1224163003698 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1224163003699 G1 box; other site 1224163003700 GTP/Mg2+ binding site [chemical binding]; other site 1224163003701 Switch I region; other site 1224163003702 G2 box; other site 1224163003703 Switch II region; other site 1224163003704 G3 box; other site 1224163003705 G4 box; other site 1224163003706 G5 box; other site 1224163003707 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1224163003708 G1 box; other site 1224163003709 GTP/Mg2+ binding site [chemical binding]; other site 1224163003710 Switch I region; other site 1224163003711 G2 box; other site 1224163003712 G3 box; other site 1224163003713 Switch II region; other site 1224163003714 G4 box; other site 1224163003715 G5 box; other site 1224163003716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1224163003717 S-adenosylmethionine binding site [chemical binding]; other site 1224163003718 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1224163003719 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 1224163003720 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1224163003721 Q-loop/lid; other site 1224163003722 ABC transporter signature motif; other site 1224163003723 Walker B; other site 1224163003724 D-loop; other site 1224163003725 H-loop/switch region; other site 1224163003726 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1224163003727 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1224163003728 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1224163003729 Walker A/P-loop; other site 1224163003730 ATP binding site [chemical binding]; other site 1224163003731 Q-loop/lid; other site 1224163003732 ABC transporter signature motif; other site 1224163003733 Walker B; other site 1224163003734 D-loop; other site 1224163003735 H-loop/switch region; other site 1224163003736 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1224163003737 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1224163003738 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1224163003739 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1224163003740 MarR family; Region: MarR; pfam01047 1224163003741 MarR family; Region: MarR_2; cl17246 1224163003742 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1224163003743 ABC1 family; Region: ABC1; cl17513 1224163003744 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 1224163003745 putative dimer interface [polypeptide binding]; other site 1224163003746 putative [2Fe-2S] cluster binding site [ion binding]; other site 1224163003747 hypothetical protein; Provisional; Region: PRK01842 1224163003748 SEC-C motif; Region: SEC-C; pfam02810 1224163003749 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1224163003750 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1224163003751 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1224163003752 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 1224163003753 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1224163003754 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1224163003755 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1224163003756 nucleotide binding region [chemical binding]; other site 1224163003757 ATP-binding site [chemical binding]; other site 1224163003758 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1224163003759 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1224163003760 phosphopeptide binding site; other site 1224163003761 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1224163003762 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1224163003763 DNA binding residues [nucleotide binding] 1224163003764 dimer interface [polypeptide binding]; other site 1224163003765 Bifunctional nuclease; Region: DNase-RNase; cl00553 1224163003766 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1224163003767 DNA binding residues [nucleotide binding] 1224163003768 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1224163003769 putative dimer interface [polypeptide binding]; other site 1224163003770 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1224163003771 metal ion-dependent adhesion site (MIDAS); other site 1224163003772 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1224163003773 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1224163003774 ATP binding site [chemical binding]; other site 1224163003775 putative Mg++ binding site [ion binding]; other site 1224163003776 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1224163003777 nucleotide binding region [chemical binding]; other site 1224163003778 ATP-binding site [chemical binding]; other site 1224163003779 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1224163003780 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1224163003781 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1224163003782 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1224163003783 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1224163003784 CoenzymeA binding site [chemical binding]; other site 1224163003785 subunit interaction site [polypeptide binding]; other site 1224163003786 PHB binding site; other site 1224163003787 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1224163003788 PhoD-like phosphatase; Region: PhoD; pfam09423 1224163003789 PhoD-like phosphatase; Region: PhoD; pfam09423 1224163003790 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1224163003791 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1224163003792 oligomer interface [polypeptide binding]; other site 1224163003793 metal binding site [ion binding]; metal-binding site 1224163003794 metal binding site [ion binding]; metal-binding site 1224163003795 putative Cl binding site [ion binding]; other site 1224163003796 basic sphincter; other site 1224163003797 hydrophobic gate; other site 1224163003798 periplasmic entrance; other site 1224163003799 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1224163003800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1224163003801 S-adenosylmethionine binding site [chemical binding]; other site 1224163003802 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1224163003803 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1224163003804 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1224163003805 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1224163003806 multifunctional hydroxymethylpyrimidine phosphokinase/4-amino-5-aminomethyl-2-methylpyrimidine hydrolase; Provisional; Region: PRK14713 1224163003807 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1224163003808 dimer interface [polypeptide binding]; other site 1224163003809 substrate binding site [chemical binding]; other site 1224163003810 ATP binding site [chemical binding]; other site 1224163003811 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1224163003812 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1224163003813 thiamine phosphate binding site [chemical binding]; other site 1224163003814 active site 1224163003815 pyrophosphate binding site [ion binding]; other site 1224163003816 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1224163003817 substrate binding site [chemical binding]; other site 1224163003818 multimerization interface [polypeptide binding]; other site 1224163003819 ATP binding site [chemical binding]; other site 1224163003820 metabolite-proton symporter; Region: 2A0106; TIGR00883 1224163003821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163003822 putative substrate translocation pore; other site 1224163003823 YceI-like domain; Region: YceI; pfam04264 1224163003824 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1224163003825 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1224163003826 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1224163003827 Ligand binding site; other site 1224163003828 Putative Catalytic site; other site 1224163003829 DXD motif; other site 1224163003830 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1224163003831 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1224163003832 putative active site [active] 1224163003833 catalytic triad [active] 1224163003834 putative dimer interface [polypeptide binding]; other site 1224163003835 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1224163003836 Secretory lipase; Region: LIP; pfam03583 1224163003837 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1224163003838 classical (c) SDRs; Region: SDR_c; cd05233 1224163003839 NAD(P) binding site [chemical binding]; other site 1224163003840 active site 1224163003841 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1224163003842 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1224163003843 putative active site [active] 1224163003844 metal binding site [ion binding]; metal-binding site 1224163003845 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1224163003846 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1224163003847 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1224163003848 active site 1224163003849 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1224163003850 CAAX protease self-immunity; Region: Abi; cl00558 1224163003851 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1224163003852 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1224163003853 ATP binding site [chemical binding]; other site 1224163003854 putative Mg++ binding site [ion binding]; other site 1224163003855 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1224163003856 nucleotide binding region [chemical binding]; other site 1224163003857 ATP-binding site [chemical binding]; other site 1224163003858 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1224163003859 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1224163003860 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1224163003861 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1224163003862 Predicted transcriptional regulator [Transcription]; Region: COG2378 1224163003863 WYL domain; Region: WYL; pfam13280 1224163003864 WYL domain; Region: WYL; pfam13280 1224163003865 Pup-ligase protein; Region: Pup_ligase; cl15463 1224163003866 Pup-like protein; Region: Pup; pfam05639 1224163003867 Pup-ligase protein; Region: Pup_ligase; cl15463 1224163003868 proteasome ATPase; Region: pup_AAA; TIGR03689 1224163003869 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1224163003870 Walker A motif; other site 1224163003871 ATP binding site [chemical binding]; other site 1224163003872 Walker B motif; other site 1224163003873 arginine finger; other site 1224163003874 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1224163003875 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1224163003876 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1224163003877 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1224163003878 active site 1224163003879 metal binding site [ion binding]; metal-binding site 1224163003880 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1224163003881 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1224163003882 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1224163003883 Potassium binding sites [ion binding]; other site 1224163003884 Cesium cation binding sites [ion binding]; other site 1224163003885 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1224163003886 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1224163003887 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1224163003888 Aspartase; Region: Aspartase; cd01357 1224163003889 active sites [active] 1224163003890 tetramer interface [polypeptide binding]; other site 1224163003891 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1224163003892 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1224163003893 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1224163003894 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1224163003895 homodimer interface [polypeptide binding]; other site 1224163003896 putative metal binding site [ion binding]; other site 1224163003897 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1224163003898 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1224163003899 motif II; other site 1224163003900 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 1224163003901 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1224163003902 active site 1224163003903 HIGH motif; other site 1224163003904 nucleotide binding site [chemical binding]; other site 1224163003905 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1224163003906 active site 1224163003907 KMSKS motif; other site 1224163003908 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1224163003909 tRNA binding surface [nucleotide binding]; other site 1224163003910 anticodon binding site; other site 1224163003911 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1224163003912 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1224163003913 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1224163003914 active site 1224163003915 catalytic tetrad [active] 1224163003916 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1224163003917 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1224163003918 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1224163003919 quinone interaction residues [chemical binding]; other site 1224163003920 active site 1224163003921 catalytic residues [active] 1224163003922 FMN binding site [chemical binding]; other site 1224163003923 substrate binding site [chemical binding]; other site 1224163003924 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1224163003925 substrate binding site [chemical binding]; other site 1224163003926 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1224163003927 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1224163003928 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1224163003929 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1224163003930 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1224163003931 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1224163003932 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1224163003933 ferrochelatase; Reviewed; Region: hemH; PRK00035 1224163003934 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1224163003935 C-terminal domain interface [polypeptide binding]; other site 1224163003936 active site 1224163003937 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1224163003938 active site 1224163003939 N-terminal domain interface [polypeptide binding]; other site 1224163003940 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1224163003941 NlpC/P60 family; Region: NLPC_P60; pfam00877 1224163003942 aconitate hydratase; Validated; Region: PRK09277 1224163003943 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1224163003944 substrate binding site [chemical binding]; other site 1224163003945 ligand binding site [chemical binding]; other site 1224163003946 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1224163003947 substrate binding site [chemical binding]; other site 1224163003948 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1224163003949 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1224163003950 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1224163003951 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1224163003952 NAD(P) binding site [chemical binding]; other site 1224163003953 active site 1224163003954 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 1224163003955 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 1224163003956 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1224163003957 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1224163003958 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1224163003959 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1224163003960 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1224163003961 motif II; other site 1224163003962 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1224163003963 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 1224163003964 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1224163003965 protein-splicing catalytic site; other site 1224163003966 thioester formation/cholesterol transfer; other site 1224163003967 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1224163003968 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1224163003969 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1224163003970 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1224163003971 Walker A/P-loop; other site 1224163003972 ATP binding site [chemical binding]; other site 1224163003973 Q-loop/lid; other site 1224163003974 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1224163003975 ABC transporter signature motif; other site 1224163003976 Walker B; other site 1224163003977 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1224163003978 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1224163003979 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1224163003980 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1224163003981 trimerization site [polypeptide binding]; other site 1224163003982 active site 1224163003983 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1224163003984 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1224163003985 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1224163003986 catalytic residue [active] 1224163003987 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1224163003988 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1224163003989 Walker A/P-loop; other site 1224163003990 ATP binding site [chemical binding]; other site 1224163003991 Q-loop/lid; other site 1224163003992 ABC transporter signature motif; other site 1224163003993 Walker B; other site 1224163003994 D-loop; other site 1224163003995 H-loop/switch region; other site 1224163003996 FeS assembly protein SufD; Region: sufD; TIGR01981 1224163003997 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1224163003998 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1224163003999 FeS assembly protein SufB; Region: sufB; TIGR01980 1224163004000 Predicted transcriptional regulator [Transcription]; Region: COG2345 1224163004001 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1224163004002 dimerization interface [polypeptide binding]; other site 1224163004003 putative DNA binding site [nucleotide binding]; other site 1224163004004 putative Zn2+ binding site [ion binding]; other site 1224163004005 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1224163004006 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1224163004007 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1224163004008 Walker A/P-loop; other site 1224163004009 ATP binding site [chemical binding]; other site 1224163004010 Q-loop/lid; other site 1224163004011 ABC transporter signature motif; other site 1224163004012 Walker B; other site 1224163004013 D-loop; other site 1224163004014 H-loop/switch region; other site 1224163004015 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1224163004016 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1224163004017 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1224163004018 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1224163004019 UbiA prenyltransferase family; Region: UbiA; pfam01040 1224163004020 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1224163004021 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1224163004022 TPP-binding site [chemical binding]; other site 1224163004023 dimer interface [polypeptide binding]; other site 1224163004024 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1224163004025 PYR/PP interface [polypeptide binding]; other site 1224163004026 dimer interface [polypeptide binding]; other site 1224163004027 TPP binding site [chemical binding]; other site 1224163004028 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1224163004029 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1224163004030 putative active site [active] 1224163004031 transaldolase; Provisional; Region: PRK03903 1224163004032 catalytic residue [active] 1224163004033 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1224163004034 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1224163004035 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1224163004036 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1224163004037 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 1224163004038 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1224163004039 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1224163004040 putative active site [active] 1224163004041 triosephosphate isomerase; Provisional; Region: PRK14567 1224163004042 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1224163004043 substrate binding site [chemical binding]; other site 1224163004044 dimer interface [polypeptide binding]; other site 1224163004045 catalytic triad [active] 1224163004046 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1224163004047 Phosphoglycerate kinase; Region: PGK; pfam00162 1224163004048 substrate binding site [chemical binding]; other site 1224163004049 hinge regions; other site 1224163004050 ADP binding site [chemical binding]; other site 1224163004051 catalytic site [active] 1224163004052 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1224163004053 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1224163004054 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1224163004055 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 1224163004056 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1224163004057 dimer interface [polypeptide binding]; other site 1224163004058 phosphate binding site [ion binding]; other site 1224163004059 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1224163004060 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1224163004061 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1224163004062 GIY-YIG motif/motif A; other site 1224163004063 active site 1224163004064 catalytic site [active] 1224163004065 putative DNA binding site [nucleotide binding]; other site 1224163004066 metal binding site [ion binding]; metal-binding site 1224163004067 UvrB/uvrC motif; Region: UVR; pfam02151 1224163004068 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1224163004069 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1224163004070 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1224163004071 homopentamer interface [polypeptide binding]; other site 1224163004072 active site 1224163004073 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1224163004074 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1224163004075 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1224163004076 dimerization interface [polypeptide binding]; other site 1224163004077 active site 1224163004078 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1224163004079 Lumazine binding domain; Region: Lum_binding; pfam00677 1224163004080 Lumazine binding domain; Region: Lum_binding; pfam00677 1224163004081 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1224163004082 catalytic motif [active] 1224163004083 Zn binding site [ion binding]; other site 1224163004084 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1224163004085 RibD C-terminal domain; Region: RibD_C; cl17279 1224163004086 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1224163004087 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1224163004088 substrate binding site [chemical binding]; other site 1224163004089 hexamer interface [polypeptide binding]; other site 1224163004090 metal binding site [ion binding]; metal-binding site 1224163004091 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1224163004092 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1224163004093 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1224163004094 S-adenosylmethionine binding site [chemical binding]; other site 1224163004095 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1224163004096 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1224163004097 putative active site [active] 1224163004098 substrate binding site [chemical binding]; other site 1224163004099 putative cosubstrate binding site; other site 1224163004100 catalytic site [active] 1224163004101 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1224163004102 substrate binding site [chemical binding]; other site 1224163004103 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1224163004104 active site 1224163004105 catalytic residues [active] 1224163004106 metal binding site [ion binding]; metal-binding site 1224163004107 primosome assembly protein PriA; Provisional; Region: PRK14873 1224163004108 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1224163004109 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1224163004110 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1224163004111 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1224163004112 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1224163004113 Flavoprotein; Region: Flavoprotein; pfam02441 1224163004114 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1224163004115 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 1224163004116 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1224163004117 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1224163004118 catalytic site [active] 1224163004119 G-X2-G-X-G-K; other site 1224163004120 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1224163004121 active site 1224163004122 dimer interface [polypeptide binding]; other site 1224163004123 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1224163004124 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1224163004125 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1224163004126 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1224163004127 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1224163004128 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1224163004129 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1224163004130 IMP binding site; other site 1224163004131 dimer interface [polypeptide binding]; other site 1224163004132 interdomain contacts; other site 1224163004133 partial ornithine binding site; other site 1224163004134 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1224163004135 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1224163004136 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1224163004137 catalytic site [active] 1224163004138 subunit interface [polypeptide binding]; other site 1224163004139 dihydroorotase; Validated; Region: pyrC; PRK09357 1224163004140 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1224163004141 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1224163004142 active site 1224163004143 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1224163004144 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1224163004145 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1224163004146 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1224163004147 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1224163004148 active site 1224163004149 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 1224163004150 putative hydrophobic ligand binding site [chemical binding]; other site 1224163004151 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1224163004152 TIGR01777 family protein; Region: yfcH 1224163004153 NAD(P) binding site [chemical binding]; other site 1224163004154 active site 1224163004155 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1224163004156 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1224163004157 transcription antitermination factor NusB; Region: nusB; TIGR01951 1224163004158 elongation factor P; Validated; Region: PRK00529 1224163004159 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1224163004160 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1224163004161 RNA binding site [nucleotide binding]; other site 1224163004162 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1224163004163 RNA binding site [nucleotide binding]; other site 1224163004164 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1224163004165 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1224163004166 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1224163004167 active site 1224163004168 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1224163004169 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1224163004170 trimer interface [polypeptide binding]; other site 1224163004171 active site 1224163004172 dimer interface [polypeptide binding]; other site 1224163004173 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1224163004174 dimer interface [polypeptide binding]; other site 1224163004175 active site 1224163004176 metal binding site [ion binding]; metal-binding site 1224163004177 shikimate kinase; Reviewed; Region: aroK; PRK00131 1224163004178 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1224163004179 ADP binding site [chemical binding]; other site 1224163004180 magnesium binding site [ion binding]; other site 1224163004181 putative shikimate binding site; other site 1224163004182 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1224163004183 chorismate synthase; Validated; Region: PRK05382 1224163004184 Tetramer interface [polypeptide binding]; other site 1224163004185 active site 1224163004186 FMN-binding site [chemical binding]; other site 1224163004187 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1224163004188 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1224163004189 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1224163004190 shikimate binding site; other site 1224163004191 NAD(P) binding site [chemical binding]; other site 1224163004192 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 1224163004193 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 1224163004194 dimerization interface [polypeptide binding]; other site 1224163004195 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1224163004196 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1224163004197 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1224163004198 motif 1; other site 1224163004199 active site 1224163004200 motif 2; other site 1224163004201 motif 3; other site 1224163004202 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1224163004203 DHHA1 domain; Region: DHHA1; pfam02272 1224163004204 recombination factor protein RarA; Reviewed; Region: PRK13342 1224163004205 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1224163004206 Walker A motif; other site 1224163004207 ATP binding site [chemical binding]; other site 1224163004208 Walker B motif; other site 1224163004209 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1224163004210 Phosphotransferase enzyme family; Region: APH; pfam01636 1224163004211 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1224163004212 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1224163004213 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1224163004214 dimer interface [polypeptide binding]; other site 1224163004215 anticodon binding site; other site 1224163004216 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1224163004217 homodimer interface [polypeptide binding]; other site 1224163004218 motif 1; other site 1224163004219 active site 1224163004220 motif 2; other site 1224163004221 GAD domain; Region: GAD; pfam02938 1224163004222 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1224163004223 active site 1224163004224 motif 3; other site 1224163004225 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1224163004226 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1224163004227 ATP binding site [chemical binding]; other site 1224163004228 putative Mg++ binding site [ion binding]; other site 1224163004229 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1224163004230 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1224163004231 nucleotide binding region [chemical binding]; other site 1224163004232 ATP-binding site [chemical binding]; other site 1224163004233 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1224163004234 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1224163004235 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1224163004236 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 1224163004237 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1224163004238 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1224163004239 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1224163004240 dimer interface [polypeptide binding]; other site 1224163004241 motif 1; other site 1224163004242 active site 1224163004243 motif 2; other site 1224163004244 motif 3; other site 1224163004245 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1224163004246 anticodon binding site; other site 1224163004247 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1224163004248 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1224163004249 dimer interface [polypeptide binding]; other site 1224163004250 catalytic triad [active] 1224163004251 peroxidatic and resolving cysteines [active] 1224163004252 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1224163004253 active site 1224163004254 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1224163004255 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1224163004256 active site 1224163004257 metal binding site [ion binding]; metal-binding site 1224163004258 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1224163004259 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1224163004260 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1224163004261 Zn2+ binding site [ion binding]; other site 1224163004262 Mg2+ binding site [ion binding]; other site 1224163004263 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1224163004264 synthetase active site [active] 1224163004265 NTP binding site [chemical binding]; other site 1224163004266 metal binding site [ion binding]; metal-binding site 1224163004267 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1224163004268 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1224163004269 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1224163004270 active site 1224163004271 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1224163004272 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1224163004273 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1224163004274 Protein export membrane protein; Region: SecD_SecF; pfam02355 1224163004275 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 1224163004276 Protein export membrane protein; Region: SecD_SecF; cl14618 1224163004277 Preprotein translocase subunit; Region: YajC; pfam02699 1224163004278 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1224163004279 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1224163004280 Walker A motif; other site 1224163004281 ATP binding site [chemical binding]; other site 1224163004282 Walker B motif; other site 1224163004283 arginine finger; other site 1224163004284 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1224163004285 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1224163004286 RuvA N terminal domain; Region: RuvA_N; pfam01330 1224163004287 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1224163004288 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1224163004289 active site 1224163004290 putative DNA-binding cleft [nucleotide binding]; other site 1224163004291 dimer interface [polypeptide binding]; other site 1224163004292 hypothetical protein; Validated; Region: PRK00110 1224163004293 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1224163004294 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1224163004295 active site 1224163004296 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1224163004297 catalytic triad [active] 1224163004298 dimer interface [polypeptide binding]; other site 1224163004299 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1224163004300 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1224163004301 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1224163004302 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1224163004303 putative acyl-acceptor binding pocket; other site 1224163004304 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1224163004305 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1224163004306 nucleotide binding site/active site [active] 1224163004307 HIT family signature motif; other site 1224163004308 catalytic residue [active] 1224163004309 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1224163004310 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1224163004311 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1224163004312 active site 1224163004313 dimer interface [polypeptide binding]; other site 1224163004314 motif 1; other site 1224163004315 motif 2; other site 1224163004316 motif 3; other site 1224163004317 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1224163004318 anticodon binding site; other site 1224163004319 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1224163004320 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1224163004321 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1224163004322 CopC domain; Region: CopC; pfam04234 1224163004323 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 1224163004324 hypothetical protein; Provisional; Region: PRK14059 1224163004325 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1224163004326 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1224163004327 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 1224163004328 SelR domain; Region: SelR; pfam01641 1224163004329 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1224163004330 Beta-lactamase; Region: Beta-lactamase; pfam00144 1224163004331 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1224163004332 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1224163004333 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1224163004334 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1224163004335 catalytic site [active] 1224163004336 putative active site [active] 1224163004337 putative substrate binding site [chemical binding]; other site 1224163004338 HRDC domain; Region: HRDC; pfam00570 1224163004339 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1224163004340 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1224163004341 TPP-binding site; other site 1224163004342 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1224163004343 PYR/PP interface [polypeptide binding]; other site 1224163004344 dimer interface [polypeptide binding]; other site 1224163004345 TPP binding site [chemical binding]; other site 1224163004346 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1224163004347 TRAM domain; Region: TRAM; pfam01938 1224163004348 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1224163004349 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1224163004350 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1224163004351 trimer interface [polypeptide binding]; other site 1224163004352 active site 1224163004353 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1224163004354 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1224163004355 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1224163004356 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1224163004357 active site 1224163004358 dimerization interface [polypeptide binding]; other site 1224163004359 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1224163004360 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1224163004361 nucleotide binding site [chemical binding]; other site 1224163004362 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1224163004363 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1224163004364 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1224163004365 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1224163004366 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1224163004367 DNA binding residues [nucleotide binding] 1224163004368 Predicted membrane protein [Function unknown]; Region: COG2311 1224163004369 Protein of unknown function (DUF418); Region: DUF418; cl12135 1224163004370 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1224163004371 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1224163004372 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1224163004373 ATP binding site [chemical binding]; other site 1224163004374 putative Mg++ binding site [ion binding]; other site 1224163004375 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1224163004376 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1224163004377 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1224163004378 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1224163004379 S-adenosylmethionine binding site [chemical binding]; other site 1224163004380 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1224163004381 putative active site [active] 1224163004382 dimerization interface [polypeptide binding]; other site 1224163004383 putative tRNAtyr binding site [nucleotide binding]; other site 1224163004384 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1224163004385 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1224163004386 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1224163004387 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1224163004388 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1224163004389 DNA binding residues [nucleotide binding] 1224163004390 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1224163004391 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1224163004392 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1224163004393 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1224163004394 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1224163004395 NAD binding site [chemical binding]; other site 1224163004396 homodimer interface [polypeptide binding]; other site 1224163004397 active site 1224163004398 substrate binding site [chemical binding]; other site 1224163004399 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1224163004400 PAC2 family; Region: PAC2; pfam09754 1224163004401 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1224163004402 ATP binding site [chemical binding]; other site 1224163004403 putative Mg++ binding site [ion binding]; other site 1224163004404 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1224163004405 nucleotide binding region [chemical binding]; other site 1224163004406 ATP-binding site [chemical binding]; other site 1224163004407 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 1224163004408 D-serine dehydratase; Provisional; Region: PRK02991 1224163004409 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1224163004410 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1224163004411 catalytic residue [active] 1224163004412 HEAT repeats; Region: HEAT_2; pfam13646 1224163004413 SdpI/YhfL protein family; Region: SdpI; pfam13630 1224163004414 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1224163004415 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1224163004416 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1224163004417 active site residue [active] 1224163004418 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1224163004419 active site residue [active] 1224163004420 Predicted transcriptional regulators [Transcription]; Region: COG1695 1224163004421 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1224163004422 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1224163004423 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1224163004424 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1224163004425 dimerization interface [polypeptide binding]; other site 1224163004426 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 1224163004427 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1224163004428 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1224163004429 ATP binding site [chemical binding]; other site 1224163004430 putative Mg++ binding site [ion binding]; other site 1224163004431 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1224163004432 nucleotide binding region [chemical binding]; other site 1224163004433 ATP-binding site [chemical binding]; other site 1224163004434 Helicase associated domain (HA2); Region: HA2; pfam04408 1224163004435 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1224163004436 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1224163004437 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1224163004438 ATP cone domain; Region: ATP-cone; pfam03477 1224163004439 LexA repressor; Validated; Region: PRK00215 1224163004440 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1224163004441 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1224163004442 Catalytic site [active] 1224163004443 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1224163004444 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1224163004445 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1224163004446 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1224163004447 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1224163004448 putative substrate binding site [chemical binding]; other site 1224163004449 putative ATP binding site [chemical binding]; other site 1224163004450 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1224163004451 dimerization domain swap beta strand [polypeptide binding]; other site 1224163004452 regulatory protein interface [polypeptide binding]; other site 1224163004453 active site 1224163004454 regulatory phosphorylation site [posttranslational modification]; other site 1224163004455 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1224163004456 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1224163004457 GTPases [General function prediction only]; Region: HflX; COG2262 1224163004458 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1224163004459 HflX GTPase family; Region: HflX; cd01878 1224163004460 G1 box; other site 1224163004461 GTP/Mg2+ binding site [chemical binding]; other site 1224163004462 Switch I region; other site 1224163004463 G2 box; other site 1224163004464 G3 box; other site 1224163004465 Switch II region; other site 1224163004466 G4 box; other site 1224163004467 G5 box; other site 1224163004468 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1224163004469 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1224163004470 Walker A/P-loop; other site 1224163004471 ATP binding site [chemical binding]; other site 1224163004472 Q-loop/lid; other site 1224163004473 ABC transporter signature motif; other site 1224163004474 Walker B; other site 1224163004475 D-loop; other site 1224163004476 H-loop/switch region; other site 1224163004477 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1224163004478 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1224163004479 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1224163004480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1224163004481 dimer interface [polypeptide binding]; other site 1224163004482 conserved gate region; other site 1224163004483 putative PBP binding loops; other site 1224163004484 ABC-ATPase subunit interface; other site 1224163004485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1224163004486 dimer interface [polypeptide binding]; other site 1224163004487 conserved gate region; other site 1224163004488 putative PBP binding loops; other site 1224163004489 ABC-ATPase subunit interface; other site 1224163004490 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1224163004491 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1224163004492 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1224163004493 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1224163004494 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1224163004495 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1224163004496 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1224163004497 putative NAD(P) binding site [chemical binding]; other site 1224163004498 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1224163004499 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1224163004500 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1224163004501 FeS/SAM binding site; other site 1224163004502 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1224163004503 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1224163004504 Walker A/P-loop; other site 1224163004505 ATP binding site [chemical binding]; other site 1224163004506 Q-loop/lid; other site 1224163004507 ABC transporter signature motif; other site 1224163004508 Walker B; other site 1224163004509 D-loop; other site 1224163004510 H-loop/switch region; other site 1224163004511 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1224163004512 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1224163004513 substrate binding pocket [chemical binding]; other site 1224163004514 membrane-bound complex binding site; other site 1224163004515 hinge residues; other site 1224163004516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1224163004517 dimer interface [polypeptide binding]; other site 1224163004518 conserved gate region; other site 1224163004519 putative PBP binding loops; other site 1224163004520 ABC-ATPase subunit interface; other site 1224163004521 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1224163004522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1224163004523 dimer interface [polypeptide binding]; other site 1224163004524 conserved gate region; other site 1224163004525 putative PBP binding loops; other site 1224163004526 ABC-ATPase subunit interface; other site 1224163004527 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1224163004528 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1224163004529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1224163004530 dimer interface [polypeptide binding]; other site 1224163004531 conserved gate region; other site 1224163004532 putative PBP binding loops; other site 1224163004533 ABC-ATPase subunit interface; other site 1224163004534 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1224163004535 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1224163004536 Walker A/P-loop; other site 1224163004537 ATP binding site [chemical binding]; other site 1224163004538 Q-loop/lid; other site 1224163004539 ABC transporter signature motif; other site 1224163004540 Walker B; other site 1224163004541 D-loop; other site 1224163004542 H-loop/switch region; other site 1224163004543 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1224163004544 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1224163004545 recombinase A; Provisional; Region: recA; PRK09354 1224163004546 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1224163004547 hexamer interface [polypeptide binding]; other site 1224163004548 Walker A motif; other site 1224163004549 ATP binding site [chemical binding]; other site 1224163004550 Walker B motif; other site 1224163004551 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1224163004552 BioY family; Region: BioY; pfam02632 1224163004553 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1224163004554 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1224163004555 Walker A/P-loop; other site 1224163004556 ATP binding site [chemical binding]; other site 1224163004557 Q-loop/lid; other site 1224163004558 ABC transporter signature motif; other site 1224163004559 Walker B; other site 1224163004560 D-loop; other site 1224163004561 H-loop/switch region; other site 1224163004562 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1224163004563 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1224163004564 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1224163004565 non-specific DNA binding site [nucleotide binding]; other site 1224163004566 salt bridge; other site 1224163004567 sequence-specific DNA binding site [nucleotide binding]; other site 1224163004568 Competence-damaged protein; Region: CinA; pfam02464 1224163004569 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1224163004570 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 1224163004571 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1224163004572 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1224163004573 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1224163004574 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1224163004575 TIGR03085 family protein; Region: TIGR03085 1224163004576 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1224163004577 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1224163004578 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1224163004579 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1224163004580 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1224163004581 dimer interface [polypeptide binding]; other site 1224163004582 active site 1224163004583 catalytic residue [active] 1224163004584 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1224163004585 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1224163004586 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1224163004587 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1224163004588 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1224163004589 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1224163004590 oligomer interface [polypeptide binding]; other site 1224163004591 RNA binding site [nucleotide binding]; other site 1224163004592 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1224163004593 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1224163004594 RNase E interface [polypeptide binding]; other site 1224163004595 trimer interface [polypeptide binding]; other site 1224163004596 active site 1224163004597 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1224163004598 putative nucleic acid binding region [nucleotide binding]; other site 1224163004599 G-X-X-G motif; other site 1224163004600 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1224163004601 RNA binding site [nucleotide binding]; other site 1224163004602 domain interface; other site 1224163004603 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1224163004604 16S/18S rRNA binding site [nucleotide binding]; other site 1224163004605 S13e-L30e interaction site [polypeptide binding]; other site 1224163004606 25S rRNA binding site [nucleotide binding]; other site 1224163004607 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 1224163004608 active site 1224163004609 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1224163004610 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1224163004611 active site 1224163004612 Riboflavin kinase; Region: Flavokinase; pfam01687 1224163004613 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1224163004614 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1224163004615 RNA binding site [nucleotide binding]; other site 1224163004616 active site 1224163004617 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1224163004618 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1224163004619 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1224163004620 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1224163004621 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1224163004622 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1224163004623 DHH family; Region: DHH; pfam01368 1224163004624 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1224163004625 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1224163004626 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1224163004627 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1224163004628 active site 1224163004629 metal binding site [ion binding]; metal-binding site 1224163004630 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1224163004631 active site 1224163004632 metal binding site [ion binding]; metal-binding site 1224163004633 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1224163004634 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1224163004635 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1224163004636 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1224163004637 G1 box; other site 1224163004638 putative GEF interaction site [polypeptide binding]; other site 1224163004639 GTP/Mg2+ binding site [chemical binding]; other site 1224163004640 Switch I region; other site 1224163004641 G2 box; other site 1224163004642 G3 box; other site 1224163004643 Switch II region; other site 1224163004644 G4 box; other site 1224163004645 G5 box; other site 1224163004646 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1224163004647 Translation-initiation factor 2; Region: IF-2; pfam11987 1224163004648 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1224163004649 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 1224163004650 putative RNA binding cleft [nucleotide binding]; other site 1224163004651 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1224163004652 NusA N-terminal domain; Region: NusA_N; pfam08529 1224163004653 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1224163004654 RNA binding site [nucleotide binding]; other site 1224163004655 homodimer interface [polypeptide binding]; other site 1224163004656 NusA-like KH domain; Region: KH_5; pfam13184 1224163004657 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1224163004658 G-X-X-G motif; other site 1224163004659 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1224163004660 Sm and related proteins; Region: Sm_like; cl00259 1224163004661 Predicted membrane protein [Function unknown]; Region: COG4270 1224163004662 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1224163004663 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1224163004664 dimer interface [polypeptide binding]; other site 1224163004665 motif 1; other site 1224163004666 active site 1224163004667 motif 2; other site 1224163004668 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1224163004669 putative deacylase active site [active] 1224163004670 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1224163004671 active site 1224163004672 motif 3; other site 1224163004673 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1224163004674 anticodon binding site; other site 1224163004675 hypothetical protein; Validated; Region: PRK02101 1224163004676 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1224163004677 Predicted membrane protein [General function prediction only]; Region: COG4194 1224163004678 DctM-like transporters; Region: DctM; pfam06808 1224163004679 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1224163004680 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1224163004681 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1224163004682 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1224163004683 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1224163004684 homodimer interface [polypeptide binding]; other site 1224163004685 active site 1224163004686 SAM binding site [chemical binding]; other site 1224163004687 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1224163004688 hypothetical protein; Validated; Region: PRK00029 1224163004689 malate:quinone oxidoreductase; Validated; Region: PRK05257 1224163004690 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1224163004691 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1224163004692 mycothione reductase; Reviewed; Region: PRK07846 1224163004693 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1224163004694 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1224163004695 methionine aminopeptidase; Provisional; Region: PRK12318 1224163004696 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1224163004697 active site 1224163004698 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1224163004699 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1224163004700 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1224163004701 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1224163004702 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1224163004703 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1224163004704 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1224163004705 active site 1224163004706 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1224163004707 protein binding site [polypeptide binding]; other site 1224163004708 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1224163004709 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1224163004710 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1224163004711 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1224163004712 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1224163004713 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 1224163004714 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1224163004715 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1224163004716 FeS/SAM binding site; other site 1224163004717 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1224163004718 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1224163004719 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1224163004720 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1224163004721 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1224163004722 hinge region; other site 1224163004723 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1224163004724 putative nucleotide binding site [chemical binding]; other site 1224163004725 uridine monophosphate binding site [chemical binding]; other site 1224163004726 homohexameric interface [polypeptide binding]; other site 1224163004727 elongation factor Ts; Provisional; Region: tsf; PRK09377 1224163004728 UBA/TS-N domain; Region: UBA; pfam00627 1224163004729 Elongation factor TS; Region: EF_TS; pfam00889 1224163004730 Elongation factor TS; Region: EF_TS; pfam00889 1224163004731 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1224163004732 rRNA interaction site [nucleotide binding]; other site 1224163004733 S8 interaction site; other site 1224163004734 putative laminin-1 binding site; other site 1224163004735 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1224163004736 Peptidase family M23; Region: Peptidase_M23; pfam01551 1224163004737 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1224163004738 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1224163004739 active site 1224163004740 DNA binding site [nucleotide binding] 1224163004741 Int/Topo IB signature motif; other site 1224163004742 Predicted membrane protein [General function prediction only]; Region: COG4194 1224163004743 DNA protecting protein DprA; Region: dprA; TIGR00732 1224163004744 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1224163004745 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1224163004746 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1224163004747 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1224163004748 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1224163004749 Walker A motif; other site 1224163004750 ATP binding site [chemical binding]; other site 1224163004751 Walker B motif; other site 1224163004752 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1224163004753 hypothetical protein; Reviewed; Region: PRK12497 1224163004754 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1224163004755 hydrophobic ligand binding site; other site 1224163004756 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1224163004757 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1224163004758 RNA/DNA hybrid binding site [nucleotide binding]; other site 1224163004759 active site 1224163004760 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1224163004761 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1224163004762 Catalytic site [active] 1224163004763 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cl01843 1224163004764 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1224163004765 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1224163004766 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1224163004767 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1224163004768 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1224163004769 thiamine phosphate binding site [chemical binding]; other site 1224163004770 pyrophosphate binding site [ion binding]; other site 1224163004771 active site 1224163004772 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1224163004773 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1224163004774 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1224163004775 thiS-thiF/thiG interaction site; other site 1224163004776 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1224163004777 ThiS interaction site; other site 1224163004778 putative active site [active] 1224163004779 tetramer interface [polypeptide binding]; other site 1224163004780 thiamine biosynthesis protein ThiF; Validated; Region: PRK05600 1224163004781 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1224163004782 ATP binding site [chemical binding]; other site 1224163004783 substrate interface [chemical binding]; other site 1224163004784 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1224163004785 active site residue [active] 1224163004786 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1224163004787 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1224163004788 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1224163004789 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1224163004790 RNA binding site [nucleotide binding]; other site 1224163004791 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1224163004792 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1224163004793 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1224163004794 RimM N-terminal domain; Region: RimM; pfam01782 1224163004795 PRC-barrel domain; Region: PRC; pfam05239 1224163004796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1224163004797 S-adenosylmethionine binding site [chemical binding]; other site 1224163004798 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1224163004799 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1224163004800 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 1224163004801 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1224163004802 FeS/SAM binding site; other site 1224163004803 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1224163004804 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1224163004805 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1224163004806 signal recognition particle protein; Provisional; Region: PRK10867 1224163004807 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1224163004808 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1224163004809 P loop; other site 1224163004810 GTP binding site [chemical binding]; other site 1224163004811 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1224163004812 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 1224163004813 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 1224163004814 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 1224163004815 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 1224163004816 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1224163004817 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 1224163004818 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 1224163004819 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1224163004820 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1224163004821 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1224163004822 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1224163004823 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1224163004824 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 1224163004825 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1224163004826 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1224163004827 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1224163004828 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1224163004829 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1224163004830 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1224163004831 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1224163004832 Walker A/P-loop; other site 1224163004833 ATP binding site [chemical binding]; other site 1224163004834 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 1224163004835 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1224163004836 ABC transporter signature motif; other site 1224163004837 Walker B; other site 1224163004838 D-loop; other site 1224163004839 H-loop/switch region; other site 1224163004840 Acylphosphatase; Region: Acylphosphatase; cl00551 1224163004841 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1224163004842 amino acid carrier protein; Region: agcS; TIGR00835 1224163004843 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1224163004844 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1224163004845 DNA binding site [nucleotide binding] 1224163004846 catalytic residue [active] 1224163004847 H2TH interface [polypeptide binding]; other site 1224163004848 putative catalytic residues [active] 1224163004849 turnover-facilitating residue; other site 1224163004850 intercalation triad [nucleotide binding]; other site 1224163004851 8OG recognition residue [nucleotide binding]; other site 1224163004852 putative reading head residues; other site 1224163004853 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1224163004854 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1224163004855 ribonuclease III; Reviewed; Region: rnc; PRK00102 1224163004856 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1224163004857 dimerization interface [polypeptide binding]; other site 1224163004858 active site 1224163004859 metal binding site [ion binding]; metal-binding site 1224163004860 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1224163004861 dsRNA binding site [nucleotide binding]; other site 1224163004862 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1224163004863 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1224163004864 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1224163004865 GAF domain; Region: GAF; pfam01590 1224163004866 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1224163004867 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1224163004868 anti sigma factor interaction site; other site 1224163004869 regulatory phosphorylation site [posttranslational modification]; other site 1224163004870 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1224163004871 glutamate dehydrogenase; Provisional; Region: PRK09414 1224163004872 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1224163004873 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1224163004874 NAD(P) binding site [chemical binding]; other site 1224163004875 Glycerate kinase family; Region: Gly_kinase; cl00841 1224163004876 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1224163004877 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1224163004878 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1224163004879 metal binding site [ion binding]; metal-binding site 1224163004880 putative dimer interface [polypeptide binding]; other site 1224163004881 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1224163004882 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1224163004883 active site pocket [active] 1224163004884 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1224163004885 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1224163004886 pyruvate kinase; Provisional; Region: PRK06247 1224163004887 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1224163004888 domain interfaces; other site 1224163004889 active site 1224163004890 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1224163004891 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1224163004892 active site 1224163004893 ribulose/triose binding site [chemical binding]; other site 1224163004894 phosphate binding site [ion binding]; other site 1224163004895 substrate (anthranilate) binding pocket [chemical binding]; other site 1224163004896 product (indole) binding pocket [chemical binding]; other site 1224163004897 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; cl17850 1224163004898 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1224163004899 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1224163004900 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1224163004901 substrate binding site [chemical binding]; other site 1224163004902 glutamase interaction surface [polypeptide binding]; other site 1224163004903 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1224163004904 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1224163004905 active site 1224163004906 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1224163004907 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1224163004908 catalytic residues [active] 1224163004909 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1224163004910 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1224163004911 Walker A/P-loop; other site 1224163004912 ATP binding site [chemical binding]; other site 1224163004913 Q-loop/lid; other site 1224163004914 ABC transporter signature motif; other site 1224163004915 Walker B; other site 1224163004916 D-loop; other site 1224163004917 H-loop/switch region; other site 1224163004918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1224163004919 dimer interface [polypeptide binding]; other site 1224163004920 conserved gate region; other site 1224163004921 putative PBP binding loops; other site 1224163004922 ABC-ATPase subunit interface; other site 1224163004923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1224163004924 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1224163004925 DinB superfamily; Region: DinB_2; pfam12867 1224163004926 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1224163004927 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1224163004928 putative active site [active] 1224163004929 oxyanion strand; other site 1224163004930 catalytic triad [active] 1224163004931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163004932 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1224163004933 putative substrate translocation pore; other site 1224163004934 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1224163004935 putative active site pocket [active] 1224163004936 4-fold oligomerization interface [polypeptide binding]; other site 1224163004937 metal binding residues [ion binding]; metal-binding site 1224163004938 3-fold/trimer interface [polypeptide binding]; other site 1224163004939 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1224163004940 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1224163004941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1224163004942 homodimer interface [polypeptide binding]; other site 1224163004943 catalytic residue [active] 1224163004944 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1224163004945 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1224163004946 NAD binding site [chemical binding]; other site 1224163004947 dimerization interface [polypeptide binding]; other site 1224163004948 product binding site; other site 1224163004949 substrate binding site [chemical binding]; other site 1224163004950 zinc binding site [ion binding]; other site 1224163004951 catalytic residues [active] 1224163004952 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1224163004953 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1224163004954 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1224163004955 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1224163004956 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1224163004957 active site 1224163004958 catalytic site [active] 1224163004959 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1224163004960 active site 1224163004961 catalytic site [active] 1224163004962 substrate binding site [chemical binding]; other site 1224163004963 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1224163004964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163004965 metabolite-proton symporter; Region: 2A0106; TIGR00883 1224163004966 putative substrate translocation pore; other site 1224163004967 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 1224163004968 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1224163004969 active site 1224163004970 catalytic site [active] 1224163004971 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1224163004972 synthetase active site [active] 1224163004973 metal binding site [ion binding]; metal-binding site 1224163004974 NTP binding site [chemical binding]; other site 1224163004975 Transcription initiation factor IIF, beta subunit; Region: TFIIF_beta; cl02122 1224163004976 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1224163004977 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1224163004978 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1224163004979 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1224163004980 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1224163004981 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1224163004982 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845 1224163004983 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1224163004984 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1224163004985 RNA binding surface [nucleotide binding]; other site 1224163004986 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1224163004987 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1224163004988 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1224163004989 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1224163004990 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1224163004991 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1224163004992 catalytic site [active] 1224163004993 active site 1224163004994 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1224163004995 threonine dehydratase; Validated; Region: PRK08639 1224163004996 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1224163004997 tetramer interface [polypeptide binding]; other site 1224163004998 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1224163004999 catalytic residue [active] 1224163005000 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1224163005001 salicylate hydroxylase; Provisional; Region: PRK08163 1224163005002 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1224163005003 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1224163005004 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1224163005005 substrate binding site [chemical binding]; other site 1224163005006 THF binding site; other site 1224163005007 zinc-binding site [ion binding]; other site 1224163005008 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1224163005009 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1224163005010 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1224163005011 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1224163005012 active site 1224163005013 PHP Thumb interface [polypeptide binding]; other site 1224163005014 metal binding site [ion binding]; metal-binding site 1224163005015 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1224163005016 generic binding surface II; other site 1224163005017 generic binding surface I; other site 1224163005018 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1224163005019 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1224163005020 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1224163005021 RNA binding surface [nucleotide binding]; other site 1224163005022 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1224163005023 active site 1224163005024 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1224163005025 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1224163005026 active site 1224163005027 homotetramer interface [polypeptide binding]; other site 1224163005028 homodimer interface [polypeptide binding]; other site 1224163005029 DNA polymerase IV; Provisional; Region: PRK03348 1224163005030 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1224163005031 active site 1224163005032 DNA binding site [nucleotide binding] 1224163005033 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 1224163005034 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1224163005035 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1224163005036 HIGH motif; other site 1224163005037 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1224163005038 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1224163005039 active site 1224163005040 KMSKS motif; other site 1224163005041 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1224163005042 tRNA binding surface [nucleotide binding]; other site 1224163005043 anticodon binding site; other site 1224163005044 DivIVA domain; Region: DivI1A_domain; TIGR03544 1224163005045 YGGT family; Region: YGGT; cl00508 1224163005046 Protein of unknown function (DUF552); Region: DUF552; pfam04472 1224163005047 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 1224163005048 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1224163005049 catalytic residue [active] 1224163005050 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1224163005051 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1224163005052 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 1224163005053 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1224163005054 nucleotide binding site [chemical binding]; other site 1224163005055 SulA interaction site; other site 1224163005056 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1224163005057 Cell division protein FtsQ; Region: FtsQ; pfam03799 1224163005058 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1224163005059 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1224163005060 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1224163005061 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1224163005062 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1224163005063 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1224163005064 active site 1224163005065 homodimer interface [polypeptide binding]; other site 1224163005066 cell division protein FtsW; Region: ftsW; TIGR02614 1224163005067 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141 1224163005068 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1224163005069 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1224163005070 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1224163005071 Mg++ binding site [ion binding]; other site 1224163005072 putative catalytic motif [active] 1224163005073 putative substrate binding site [chemical binding]; other site 1224163005074 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1224163005075 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1224163005076 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1224163005077 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1224163005078 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1224163005079 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1224163005080 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1224163005081 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1224163005082 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1224163005083 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1224163005084 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1224163005085 MraW methylase family; Region: Methyltransf_5; cl17771 1224163005086 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1224163005087 cell division protein MraZ; Reviewed; Region: PRK00326 1224163005088 MraZ protein; Region: MraZ; pfam02381 1224163005089 MraZ protein; Region: MraZ; pfam02381 1224163005090 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1224163005091 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1224163005092 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1224163005093 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1224163005094 substrate binding pocket [chemical binding]; other site 1224163005095 chain length determination region; other site 1224163005096 substrate-Mg2+ binding site; other site 1224163005097 catalytic residues [active] 1224163005098 aspartate-rich region 1; other site 1224163005099 active site lid residues [active] 1224163005100 aspartate-rich region 2; other site 1224163005101 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1224163005102 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1224163005103 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1224163005104 active site 1224163005105 ATP binding site [chemical binding]; other site 1224163005106 substrate binding site [chemical binding]; other site 1224163005107 activation loop (A-loop); other site 1224163005108 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1224163005109 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1224163005110 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1224163005111 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1224163005112 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1224163005113 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1224163005114 Predicted membrane protein [Function unknown]; Region: COG4763 1224163005115 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1224163005116 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1224163005117 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1224163005118 putative acyl-acceptor binding pocket; other site 1224163005119 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1224163005120 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1224163005121 nucleotide binding site [chemical binding]; other site 1224163005122 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1224163005123 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1224163005124 NlpC/P60 family; Region: NLPC_P60; pfam00877 1224163005125 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1224163005126 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1224163005127 NlpC/P60 family; Region: NLPC_P60; pfam00877 1224163005128 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1224163005129 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1224163005130 heme bH binding site [chemical binding]; other site 1224163005131 intrachain domain interface; other site 1224163005132 heme bL binding site [chemical binding]; other site 1224163005133 interchain domain interface [polypeptide binding]; other site 1224163005134 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1224163005135 Qo binding site; other site 1224163005136 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1224163005137 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1224163005138 iron-sulfur cluster [ion binding]; other site 1224163005139 [2Fe-2S] cluster binding site [ion binding]; other site 1224163005140 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1224163005141 Cytochrome c; Region: Cytochrom_C; pfam00034 1224163005142 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1224163005143 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1224163005144 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1224163005145 Subunit I/III interface [polypeptide binding]; other site 1224163005146 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1224163005147 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1224163005148 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1224163005149 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1224163005150 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1224163005151 active site 1224163005152 dimer interface [polypeptide binding]; other site 1224163005153 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1224163005154 Ligand Binding Site [chemical binding]; other site 1224163005155 Molecular Tunnel; other site 1224163005156 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 1224163005157 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1224163005158 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1224163005159 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1224163005160 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1224163005161 active site pocket [active] 1224163005162 putative dimer interface [polypeptide binding]; other site 1224163005163 putative cataytic base [active] 1224163005164 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1224163005165 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1224163005166 homodimer interface [polypeptide binding]; other site 1224163005167 substrate-cofactor binding pocket; other site 1224163005168 catalytic residue [active] 1224163005169 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1224163005170 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1224163005171 interface (dimer of trimers) [polypeptide binding]; other site 1224163005172 Substrate-binding/catalytic site; other site 1224163005173 Zn-binding sites [ion binding]; other site 1224163005174 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1224163005175 E3 interaction surface; other site 1224163005176 lipoyl attachment site [posttranslational modification]; other site 1224163005177 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1224163005178 E3 interaction surface; other site 1224163005179 lipoyl attachment site [posttranslational modification]; other site 1224163005180 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1224163005181 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1224163005182 E3 interaction surface; other site 1224163005183 lipoyl attachment site [posttranslational modification]; other site 1224163005184 e3 binding domain; Region: E3_binding; pfam02817 1224163005185 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1224163005186 lipoate-protein ligase B; Provisional; Region: PRK14345 1224163005187 lipoyl synthase; Provisional; Region: PRK05481 1224163005188 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1224163005189 FeS/SAM binding site; other site 1224163005190 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1224163005191 glutamine synthetase, type I; Region: GlnA; TIGR00653 1224163005192 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1224163005193 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1224163005194 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1224163005195 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1224163005196 heme binding pocket [chemical binding]; other site 1224163005197 heme ligand [chemical binding]; other site 1224163005198 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1224163005199 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 1224163005200 nudix motif; other site 1224163005201 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1224163005202 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1224163005203 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1224163005204 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1224163005205 catalytic residue [active] 1224163005206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163005207 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1224163005208 putative substrate translocation pore; other site 1224163005209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163005210 Predicted ATPase [General function prediction only]; Region: COG3910 1224163005211 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1224163005212 Walker A/P-loop; other site 1224163005213 ATP binding site [chemical binding]; other site 1224163005214 Q-loop/lid; other site 1224163005215 ABC transporter signature motif; other site 1224163005216 Walker B; other site 1224163005217 D-loop; other site 1224163005218 H-loop/switch region; other site 1224163005219 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1224163005220 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1224163005221 metal binding triad; other site 1224163005222 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1224163005223 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1224163005224 metal binding triad; other site 1224163005225 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1224163005226 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1224163005227 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1224163005228 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1224163005229 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 1224163005230 putative active site; other site 1224163005231 putative metal binding residues [ion binding]; other site 1224163005232 signature motif; other site 1224163005233 putative triphosphate binding site [ion binding]; other site 1224163005234 CHAD domain; Region: CHAD; pfam05235 1224163005235 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1224163005236 RNB domain; Region: RNB; pfam00773 1224163005237 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 1224163005238 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1224163005239 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1224163005240 RNA/DNA hybrid binding site [nucleotide binding]; other site 1224163005241 active site 1224163005242 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1224163005243 catalytic core [active] 1224163005244 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1224163005245 Putative zinc ribbon domain; Region: DUF164; pfam02591 1224163005246 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1224163005247 Probable transposase; Region: OrfB_IS605; pfam01385 1224163005248 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1224163005249 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1224163005250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1224163005251 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1224163005252 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1224163005253 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1224163005254 motif II; other site 1224163005255 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1224163005256 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1224163005257 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1224163005258 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1224163005259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163005260 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1224163005261 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1224163005262 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1224163005263 dimer interface [polypeptide binding]; other site 1224163005264 TPP-binding site [chemical binding]; other site 1224163005265 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 1224163005266 acyl carrier protein; Provisional; Region: acpP; PRK00982 1224163005267 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1224163005268 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1224163005269 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1224163005270 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1224163005271 Amidase; Region: Amidase; pfam01425 1224163005272 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1224163005273 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1224163005274 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1224163005275 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1224163005276 active site 1224163005277 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1224163005278 arsenical-resistance protein; Region: acr3; TIGR00832 1224163005279 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1224163005280 dimerization interface [polypeptide binding]; other site 1224163005281 putative DNA binding site [nucleotide binding]; other site 1224163005282 putative Zn2+ binding site [ion binding]; other site 1224163005283 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1224163005284 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1224163005285 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1224163005286 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1224163005287 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1224163005288 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1224163005289 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1224163005290 Beta-lactamase; Region: Beta-lactamase; pfam00144 1224163005291 Predicted membrane protein [Function unknown]; Region: COG2860 1224163005292 UPF0126 domain; Region: UPF0126; pfam03458 1224163005293 UPF0126 domain; Region: UPF0126; pfam03458 1224163005294 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 1224163005295 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1224163005296 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1224163005297 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1224163005298 catalytic residue [active] 1224163005299 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1224163005300 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 1224163005301 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1224163005302 DUF218 domain; Region: DUF218; pfam02698 1224163005303 putative active site [active] 1224163005304 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1224163005305 NAD(P) binding site [chemical binding]; other site 1224163005306 active site 1224163005307 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1224163005308 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1224163005309 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1224163005310 active site 1224163005311 homodimer interface [polypeptide binding]; other site 1224163005312 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1224163005313 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1224163005314 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1224163005315 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1224163005316 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1224163005317 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1224163005318 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1224163005319 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 1224163005320 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1224163005321 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1224163005322 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1224163005323 inhibitor-cofactor binding pocket; inhibition site 1224163005324 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1224163005325 catalytic residue [active] 1224163005326 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 1224163005327 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1224163005328 NAD(P) binding site [chemical binding]; other site 1224163005329 homodimer interface [polypeptide binding]; other site 1224163005330 substrate binding site [chemical binding]; other site 1224163005331 active site 1224163005332 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 1224163005333 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1224163005334 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 1224163005335 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1224163005336 NAD(P) binding site [chemical binding]; other site 1224163005337 homodimer interface [polypeptide binding]; other site 1224163005338 substrate binding site [chemical binding]; other site 1224163005339 active site 1224163005340 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1224163005341 Chain length determinant protein; Region: Wzz; cl15801 1224163005342 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1224163005343 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1224163005344 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1224163005345 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1224163005346 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1224163005347 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1224163005348 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 1224163005349 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1224163005350 active site 1224163005351 Cupin domain; Region: Cupin_2; cl17218 1224163005352 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1224163005353 PhoD-like phosphatase; Region: PhoD; pfam09423 1224163005354 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1224163005355 putative active site [active] 1224163005356 putative metal binding site [ion binding]; other site 1224163005357 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1224163005358 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1224163005359 putative metal binding site [ion binding]; other site 1224163005360 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1224163005361 active site 1224163005362 DctM-like transporters; Region: DctM; pfam06808 1224163005363 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1224163005364 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1224163005365 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1224163005366 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1224163005367 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1224163005368 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1224163005369 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1224163005370 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1224163005371 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1224163005372 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1224163005373 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1224163005374 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1224163005375 NAD(P) binding site [chemical binding]; other site 1224163005376 active site 1224163005377 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1224163005378 Cytochrome P450; Region: p450; cl12078 1224163005379 hypothetical protein; Provisional; Region: PRK06194 1224163005380 classical (c) SDRs; Region: SDR_c; cd05233 1224163005381 NAD(P) binding site [chemical binding]; other site 1224163005382 active site 1224163005383 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1224163005384 catalytic loop [active] 1224163005385 iron binding site [ion binding]; other site 1224163005386 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1224163005387 active site 1224163005388 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1224163005389 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1224163005390 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 1224163005391 NAD(P) binding site [chemical binding]; other site 1224163005392 catalytic residues [active] 1224163005393 catalytic residues [active] 1224163005394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1224163005395 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1224163005396 NAD(P) binding site [chemical binding]; other site 1224163005397 active site 1224163005398 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1224163005399 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1224163005400 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1224163005401 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1224163005402 DNA-binding site [nucleotide binding]; DNA binding site 1224163005403 FCD domain; Region: FCD; pfam07729 1224163005404 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1224163005405 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1224163005406 Excalibur calcium-binding domain; Region: Excalibur; cl05460 1224163005407 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1224163005408 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1224163005409 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1224163005410 active site 1224163005411 metal binding site [ion binding]; metal-binding site 1224163005412 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 1224163005413 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1224163005414 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1224163005415 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 1224163005416 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1224163005417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1224163005418 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1224163005419 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1224163005420 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1224163005421 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1224163005422 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 1224163005423 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1224163005424 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1224163005425 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1224163005426 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1224163005427 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 1224163005428 PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063 1224163005429 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1224163005430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1224163005431 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1224163005432 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1224163005433 PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063 1224163005434 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1224163005435 putative glycosyl transferase; Provisional; Region: PRK10307 1224163005436 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1224163005437 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1224163005438 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1224163005439 dimer interface [polypeptide binding]; other site 1224163005440 putative radical transfer pathway; other site 1224163005441 diiron center [ion binding]; other site 1224163005442 tyrosyl radical; other site 1224163005443 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1224163005444 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1224163005445 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1224163005446 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1224163005447 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1224163005448 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1224163005449 TspO/MBR family; Region: TspO_MBR; pfam03073 1224163005450 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1224163005451 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1224163005452 active site 1224163005453 DNA binding site [nucleotide binding] 1224163005454 Int/Topo IB signature motif; other site 1224163005455 oxidoreductase; Provisional; Region: PRK06128 1224163005456 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1224163005457 NAD(P) binding site [chemical binding]; other site 1224163005458 active site 1224163005459 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1224163005460 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1224163005461 active site 1224163005462 homodimer interface [polypeptide binding]; other site 1224163005463 YwiC-like protein; Region: YwiC; pfam14256 1224163005464 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 1224163005465 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1224163005466 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1224163005467 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1224163005468 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1224163005469 Protein of unknown function (DUF503); Region: DUF503; pfam04456 1224163005470 DNA primase; Validated; Region: dnaG; PRK05667 1224163005471 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1224163005472 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1224163005473 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1224163005474 active site 1224163005475 metal binding site [ion binding]; metal-binding site 1224163005476 interdomain interaction site; other site 1224163005477 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1224163005478 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1224163005479 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 1224163005480 active site 1224163005481 barstar interaction site; other site 1224163005482 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1224163005483 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1224163005484 Zn2+ binding site [ion binding]; other site 1224163005485 Mg2+ binding site [ion binding]; other site 1224163005486 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1224163005487 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1224163005488 putative active site [active] 1224163005489 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1224163005490 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1224163005491 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1224163005492 motif 1; other site 1224163005493 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1224163005494 active site 1224163005495 motif 2; other site 1224163005496 motif 3; other site 1224163005497 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1224163005498 anticodon binding site; other site 1224163005499 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1224163005500 dimerization interface [polypeptide binding]; other site 1224163005501 putative DNA binding site [nucleotide binding]; other site 1224163005502 putative Zn2+ binding site [ion binding]; other site 1224163005503 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1224163005504 metal binding site 2 [ion binding]; metal-binding site 1224163005505 putative DNA binding helix; other site 1224163005506 metal binding site 1 [ion binding]; metal-binding site 1224163005507 dimer interface [polypeptide binding]; other site 1224163005508 structural Zn2+ binding site [ion binding]; other site 1224163005509 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 1224163005510 diiron binding motif [ion binding]; other site 1224163005511 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 1224163005512 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1224163005513 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1224163005514 catalytic residue [active] 1224163005515 putative FPP diphosphate binding site; other site 1224163005516 putative FPP binding hydrophobic cleft; other site 1224163005517 dimer interface [polypeptide binding]; other site 1224163005518 putative IPP diphosphate binding site; other site 1224163005519 Recombination protein O N terminal; Region: RecO_N; pfam11967 1224163005520 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1224163005521 Recombination protein O C terminal; Region: RecO_C; pfam02565 1224163005522 GTPase Era; Reviewed; Region: era; PRK00089 1224163005523 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1224163005524 G1 box; other site 1224163005525 GTP/Mg2+ binding site [chemical binding]; other site 1224163005526 Switch I region; other site 1224163005527 G2 box; other site 1224163005528 Switch II region; other site 1224163005529 G3 box; other site 1224163005530 G4 box; other site 1224163005531 G5 box; other site 1224163005532 KH domain; Region: KH_2; pfam07650 1224163005533 pyridoxamine kinase; Validated; Region: PRK05756 1224163005534 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1224163005535 dimer interface [polypeptide binding]; other site 1224163005536 pyridoxal binding site [chemical binding]; other site 1224163005537 ATP binding site [chemical binding]; other site 1224163005538 metal-binding heat shock protein; Provisional; Region: PRK00016 1224163005539 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1224163005540 PhoH-like protein; Region: PhoH; pfam02562 1224163005541 RNA methyltransferase, RsmE family; Region: TIGR00046 1224163005542 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 1224163005543 chaperone protein DnaJ; Provisional; Region: PRK14278 1224163005544 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1224163005545 HSP70 interaction site [polypeptide binding]; other site 1224163005546 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1224163005547 Zn binding sites [ion binding]; other site 1224163005548 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1224163005549 dimer interface [polypeptide binding]; other site 1224163005550 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1224163005551 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1224163005552 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1224163005553 FeS/SAM binding site; other site 1224163005554 HemN C-terminal domain; Region: HemN_C; pfam06969 1224163005555 Domain of unknown function DUF21; Region: DUF21; pfam01595 1224163005556 FOG: CBS domain [General function prediction only]; Region: COG0517 1224163005557 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1224163005558 Transporter associated domain; Region: CorC_HlyC; pfam03471 1224163005559 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1224163005560 Domain of unknown function DUF21; Region: DUF21; pfam01595 1224163005561 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1224163005562 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1224163005563 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1224163005564 acyl-activating enzyme (AAE) consensus motif; other site 1224163005565 putative AMP binding site [chemical binding]; other site 1224163005566 putative active site [active] 1224163005567 putative CoA binding site [chemical binding]; other site 1224163005568 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1224163005569 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1224163005570 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1224163005571 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1224163005572 active site 1224163005573 Zn binding site [ion binding]; other site 1224163005574 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1224163005575 substrate binding pocket [chemical binding]; other site 1224163005576 catalytic triad [active] 1224163005577 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1224163005578 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1224163005579 active site 1224163005580 metal binding site [ion binding]; metal-binding site 1224163005581 nudix motif; other site 1224163005582 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1224163005583 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1224163005584 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1224163005585 Walker A/P-loop; other site 1224163005586 ATP binding site [chemical binding]; other site 1224163005587 Q-loop/lid; other site 1224163005588 ABC transporter signature motif; other site 1224163005589 Walker B; other site 1224163005590 D-loop; other site 1224163005591 H-loop/switch region; other site 1224163005592 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1224163005593 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1224163005594 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1224163005595 homodimer interface [polypeptide binding]; other site 1224163005596 catalytic residue [active] 1224163005597 trehalose synthase; Region: treS_nterm; TIGR02456 1224163005598 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1224163005599 active site 1224163005600 catalytic site [active] 1224163005601 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1224163005602 Phosphotransferase enzyme family; Region: APH; pfam01636 1224163005603 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1224163005604 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1224163005605 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1224163005606 BCCT family transporter; Region: BCCT; pfam02028 1224163005607 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1224163005608 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1224163005609 DNA-binding site [nucleotide binding]; DNA binding site 1224163005610 UTRA domain; Region: UTRA; pfam07702 1224163005611 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1224163005612 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 1224163005613 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1224163005614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1224163005615 dimer interface [polypeptide binding]; other site 1224163005616 conserved gate region; other site 1224163005617 putative PBP binding loops; other site 1224163005618 ABC-ATPase subunit interface; other site 1224163005619 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1224163005620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1224163005621 dimer interface [polypeptide binding]; other site 1224163005622 conserved gate region; other site 1224163005623 putative PBP binding loops; other site 1224163005624 ABC-ATPase subunit interface; other site 1224163005625 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1224163005626 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1224163005627 Walker A/P-loop; other site 1224163005628 ATP binding site [chemical binding]; other site 1224163005629 Q-loop/lid; other site 1224163005630 ABC transporter signature motif; other site 1224163005631 Walker B; other site 1224163005632 D-loop; other site 1224163005633 H-loop/switch region; other site 1224163005634 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1224163005635 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1224163005636 Walker A/P-loop; other site 1224163005637 ATP binding site [chemical binding]; other site 1224163005638 Q-loop/lid; other site 1224163005639 ABC transporter signature motif; other site 1224163005640 Walker B; other site 1224163005641 D-loop; other site 1224163005642 H-loop/switch region; other site 1224163005643 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1224163005644 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1224163005645 active site 1224163005646 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1224163005647 Sodium Bile acid symporter family; Region: SBF; pfam01758 1224163005648 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 1224163005649 active site 1224163005650 catalytic residues [active] 1224163005651 Sulphur transport; Region: Sulf_transp; pfam04143 1224163005652 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1224163005653 CPxP motif; other site 1224163005654 Predicted membrane protein [Function unknown]; Region: COG1289 1224163005655 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1224163005656 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1224163005657 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1224163005658 active site 1224163005659 metal binding site [ion binding]; metal-binding site 1224163005660 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1224163005661 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1224163005662 catalytic residues [active] 1224163005663 BCCT family transporter; Region: BCCT; pfam02028 1224163005664 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1224163005665 nucleotide binding site [chemical binding]; other site 1224163005666 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1224163005667 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1224163005668 GTP-binding protein LepA; Provisional; Region: PRK05433 1224163005669 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1224163005670 G1 box; other site 1224163005671 putative GEF interaction site [polypeptide binding]; other site 1224163005672 GTP/Mg2+ binding site [chemical binding]; other site 1224163005673 Switch I region; other site 1224163005674 G2 box; other site 1224163005675 G3 box; other site 1224163005676 Switch II region; other site 1224163005677 G4 box; other site 1224163005678 G5 box; other site 1224163005679 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1224163005680 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1224163005681 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1224163005682 PemK-like protein; Region: PemK; cl00995 1224163005683 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1224163005684 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1224163005685 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1224163005686 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 1224163005687 hypothetical protein; Validated; Region: PRK05629 1224163005688 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1224163005689 Competence protein; Region: Competence; cl00471 1224163005690 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1224163005691 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1224163005692 EDD domain protein, DegV family; Region: DegV; TIGR00762 1224163005693 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1224163005694 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1224163005695 catalytic core [active] 1224163005696 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1224163005697 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1224163005698 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1224163005699 active site 1224163005700 (T/H)XGH motif; other site 1224163005701 Cutinase; Region: Cutinase; pfam01083 1224163005702 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1224163005703 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1224163005704 putative catalytic cysteine [active] 1224163005705 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 1224163005706 putative ligand binding site [chemical binding]; other site 1224163005707 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1224163005708 putative NAD binding site [chemical binding]; other site 1224163005709 catalytic site [active] 1224163005710 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 1224163005711 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1224163005712 putative ligand binding site [chemical binding]; other site 1224163005713 putative NAD binding site [chemical binding]; other site 1224163005714 catalytic site [active] 1224163005715 gamma-glutamyl kinase; Provisional; Region: PRK05429 1224163005716 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1224163005717 nucleotide binding site [chemical binding]; other site 1224163005718 homotetrameric interface [polypeptide binding]; other site 1224163005719 putative phosphate binding site [ion binding]; other site 1224163005720 putative allosteric binding site; other site 1224163005721 PUA domain; Region: PUA; pfam01472 1224163005722 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1224163005723 GTP1/OBG; Region: GTP1_OBG; pfam01018 1224163005724 Obg GTPase; Region: Obg; cd01898 1224163005725 G1 box; other site 1224163005726 GTP/Mg2+ binding site [chemical binding]; other site 1224163005727 Switch I region; other site 1224163005728 G2 box; other site 1224163005729 G3 box; other site 1224163005730 Switch II region; other site 1224163005731 G4 box; other site 1224163005732 G5 box; other site 1224163005733 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1224163005734 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1224163005735 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1224163005736 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1224163005737 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1224163005738 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1224163005739 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1224163005740 homodimer interface [polypeptide binding]; other site 1224163005741 oligonucleotide binding site [chemical binding]; other site 1224163005742 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1224163005743 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1224163005744 active site 1224163005745 multimer interface [polypeptide binding]; other site 1224163005746 Pirin-related protein [General function prediction only]; Region: COG1741 1224163005747 Pirin; Region: Pirin; pfam02678 1224163005748 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1224163005749 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1224163005750 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1224163005751 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1224163005752 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1224163005753 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1224163005754 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1224163005755 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1224163005756 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1224163005757 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1224163005758 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1224163005759 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1224163005760 active site 1224163005761 HIGH motif; other site 1224163005762 nucleotide binding site [chemical binding]; other site 1224163005763 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1224163005764 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1224163005765 active site 1224163005766 KMSKS motif; other site 1224163005767 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1224163005768 tRNA binding surface [nucleotide binding]; other site 1224163005769 anticodon binding site; other site 1224163005770 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1224163005771 MreB/Mbl protein; Region: MreB_Mbl; pfam06723 1224163005772 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1224163005773 nucleotide binding site [chemical binding]; other site 1224163005774 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1224163005775 SBD interface [polypeptide binding]; other site 1224163005776 malate dehydrogenase; Provisional; Region: PRK05442 1224163005777 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1224163005778 NAD(P) binding site [chemical binding]; other site 1224163005779 dimer interface [polypeptide binding]; other site 1224163005780 malate binding site [chemical binding]; other site 1224163005781 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1224163005782 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1224163005783 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1224163005784 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 1224163005785 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1224163005786 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1224163005787 Walker A motif; other site 1224163005788 ATP binding site [chemical binding]; other site 1224163005789 Walker B motif; other site 1224163005790 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1224163005791 Predicted membrane protein [Function unknown]; Region: COG4125 1224163005792 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1224163005793 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1224163005794 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1224163005795 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1224163005796 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1224163005797 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1224163005798 Bacterial transcriptional regulator; Region: IclR; pfam01614 1224163005799 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 1224163005800 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1224163005801 dimer interface [polypeptide binding]; other site 1224163005802 active site 1224163005803 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1224163005804 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1224163005805 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1224163005806 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1224163005807 NAD(P) binding site [chemical binding]; other site 1224163005808 putative active site [active] 1224163005809 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1224163005810 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1224163005811 DNA binding residues [nucleotide binding] 1224163005812 dimerization interface [polypeptide binding]; other site 1224163005813 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1224163005814 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1224163005815 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1224163005816 NAD(P) binding site [chemical binding]; other site 1224163005817 active site 1224163005818 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 1224163005819 benzoate transporter; Region: benE; TIGR00843 1224163005820 benzoate transport; Region: 2A0115; TIGR00895 1224163005821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163005822 putative substrate translocation pore; other site 1224163005823 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1224163005824 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1224163005825 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1224163005826 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1224163005827 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1224163005828 tetramer interface [polypeptide binding]; other site 1224163005829 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 1224163005830 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1224163005831 active site 1224163005832 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1224163005833 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1224163005834 active site 1224163005835 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1224163005836 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1224163005837 DNA-binding site [nucleotide binding]; DNA binding site 1224163005838 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1224163005839 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1224163005840 homodimer interface [polypeptide binding]; other site 1224163005841 catalytic residue [active] 1224163005842 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1224163005843 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1224163005844 active site 1224163005845 multimer interface [polypeptide binding]; other site 1224163005846 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 1224163005847 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1224163005848 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 1224163005849 metal binding site [ion binding]; metal-binding site 1224163005850 substrate binding pocket [chemical binding]; other site 1224163005851 catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438 1224163005852 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1224163005853 active site 1224163005854 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 1224163005855 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1224163005856 iron-sulfur cluster [ion binding]; other site 1224163005857 [2Fe-2S] cluster binding site [ion binding]; other site 1224163005858 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1224163005859 putative alpha subunit interface [polypeptide binding]; other site 1224163005860 putative active site [active] 1224163005861 putative substrate binding site [chemical binding]; other site 1224163005862 Fe binding site [ion binding]; other site 1224163005863 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1224163005864 inter-subunit interface; other site 1224163005865 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 1224163005866 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1224163005867 catalytic loop [active] 1224163005868 iron binding site [ion binding]; other site 1224163005869 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 1224163005870 FAD binding pocket [chemical binding]; other site 1224163005871 FAD binding motif [chemical binding]; other site 1224163005872 phosphate binding motif [ion binding]; other site 1224163005873 beta-alpha-beta structure motif; other site 1224163005874 NAD binding pocket [chemical binding]; other site 1224163005875 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1224163005876 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1224163005877 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 1224163005878 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1224163005879 NAD(P) binding site [chemical binding]; other site 1224163005880 active site 1224163005881 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1224163005882 AAA ATPase domain; Region: AAA_16; pfam13191 1224163005883 Walker A motif; other site 1224163005884 ATP binding site [chemical binding]; other site 1224163005885 Walker B motif; other site 1224163005886 arginine finger; other site 1224163005887 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1224163005888 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1224163005889 DNA binding residues [nucleotide binding] 1224163005890 dimerization interface [polypeptide binding]; other site 1224163005891 benzoate transport; Region: 2A0115; TIGR00895 1224163005892 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163005893 putative substrate translocation pore; other site 1224163005894 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1224163005895 iron-sulfur cluster [ion binding]; other site 1224163005896 [2Fe-2S] cluster binding site [ion binding]; other site 1224163005897 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1224163005898 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1224163005899 oligomer interface [polypeptide binding]; other site 1224163005900 active site residues [active] 1224163005901 Clp protease; Region: CLP_protease; pfam00574 1224163005902 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1224163005903 oligomer interface [polypeptide binding]; other site 1224163005904 active site residues [active] 1224163005905 glutamine synthetase, type I; Region: GlnA; TIGR00653 1224163005906 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1224163005907 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1224163005908 ornithine cyclodeaminase; Validated; Region: PRK06199 1224163005909 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1224163005910 trigger factor; Provisional; Region: tig; PRK01490 1224163005911 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1224163005912 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1224163005913 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1224163005914 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1224163005915 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1224163005916 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1224163005917 Zn binding site [ion binding]; other site 1224163005918 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1224163005919 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1224163005920 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1224163005921 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1224163005922 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1224163005923 dimerization interface [polypeptide binding]; other site 1224163005924 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1224163005925 dimer interface [polypeptide binding]; other site 1224163005926 phosphorylation site [posttranslational modification] 1224163005927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1224163005928 ATP binding site [chemical binding]; other site 1224163005929 Mg2+ binding site [ion binding]; other site 1224163005930 G-X-G motif; other site 1224163005931 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1224163005932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1224163005933 active site 1224163005934 phosphorylation site [posttranslational modification] 1224163005935 intermolecular recognition site; other site 1224163005936 dimerization interface [polypeptide binding]; other site 1224163005937 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1224163005938 DNA binding site [nucleotide binding] 1224163005939 CMD domain protein, Avi_7170 family; Region: CMD_Avi_7170; TIGR04029 1224163005940 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1224163005941 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1224163005942 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1224163005943 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1224163005944 Walker A/P-loop; other site 1224163005945 ATP binding site [chemical binding]; other site 1224163005946 Q-loop/lid; other site 1224163005947 ABC transporter signature motif; other site 1224163005948 Walker B; other site 1224163005949 D-loop; other site 1224163005950 H-loop/switch region; other site 1224163005951 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1224163005952 Walker A/P-loop; other site 1224163005953 ATP binding site [chemical binding]; other site 1224163005954 Q-loop/lid; other site 1224163005955 ABC transporter signature motif; other site 1224163005956 Walker B; other site 1224163005957 D-loop; other site 1224163005958 H-loop/switch region; other site 1224163005959 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1224163005960 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1224163005961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1224163005962 putative PBP binding loops; other site 1224163005963 ABC-ATPase subunit interface; other site 1224163005964 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1224163005965 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1224163005966 dimer interface [polypeptide binding]; other site 1224163005967 conserved gate region; other site 1224163005968 putative PBP binding loops; other site 1224163005969 ABC-ATPase subunit interface; other site 1224163005970 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 1224163005971 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1224163005972 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1224163005973 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1224163005974 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1224163005975 DNA-binding site [nucleotide binding]; DNA binding site 1224163005976 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1224163005977 cystathionine gamma-synthase; Provisional; Region: PRK07811 1224163005978 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1224163005979 homodimer interface [polypeptide binding]; other site 1224163005980 substrate-cofactor binding pocket; other site 1224163005981 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1224163005982 catalytic residue [active] 1224163005983 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1224163005984 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1224163005985 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1224163005986 apolar tunnel; other site 1224163005987 heme binding site [chemical binding]; other site 1224163005988 dimerization interface [polypeptide binding]; other site 1224163005989 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1224163005990 Chromate transporter; Region: Chromate_transp; pfam02417 1224163005991 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1224163005992 active site 1224163005993 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1224163005994 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1224163005995 Walker A/P-loop; other site 1224163005996 ATP binding site [chemical binding]; other site 1224163005997 Q-loop/lid; other site 1224163005998 ABC transporter signature motif; other site 1224163005999 Walker B; other site 1224163006000 D-loop; other site 1224163006001 H-loop/switch region; other site 1224163006002 ABC transporter; Region: ABC_tran_2; pfam12848 1224163006003 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1224163006004 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1224163006005 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1224163006006 dimer interface [polypeptide binding]; other site 1224163006007 ssDNA binding site [nucleotide binding]; other site 1224163006008 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1224163006009 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1224163006010 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1224163006011 Ferritin-like domain; Region: Ferritin; pfam00210 1224163006012 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1224163006013 dimerization interface [polypeptide binding]; other site 1224163006014 DPS ferroxidase diiron center [ion binding]; other site 1224163006015 ion pore; other site 1224163006016 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1224163006017 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 1224163006018 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 1224163006019 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 1224163006020 Ligand Binding Site [chemical binding]; other site 1224163006021 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 1224163006022 AIR carboxylase; Region: AIRC; smart01001 1224163006023 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1224163006024 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1224163006025 RNA binding surface [nucleotide binding]; other site 1224163006026 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1224163006027 active site 1224163006028 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1224163006029 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1224163006030 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1224163006031 DNA binding site [nucleotide binding] 1224163006032 active site 1224163006033 hypothetical protein; Provisional; Region: PRK04194 1224163006034 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 1224163006035 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1224163006036 classical (c) SDRs; Region: SDR_c; cd05233 1224163006037 NAD(P) binding site [chemical binding]; other site 1224163006038 active site 1224163006039 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1224163006040 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1224163006041 FeS/SAM binding site; other site 1224163006042 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1224163006043 ATP cone domain; Region: ATP-cone; pfam03477 1224163006044 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1224163006045 effector binding site; other site 1224163006046 active site 1224163006047 Zn binding site [ion binding]; other site 1224163006048 glycine loop; other site 1224163006049 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1224163006050 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1224163006051 catalytic site [active] 1224163006052 putative active site [active] 1224163006053 putative substrate binding site [chemical binding]; other site 1224163006054 dimer interface [polypeptide binding]; other site 1224163006055 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1224163006056 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1224163006057 NAD(P) binding site [chemical binding]; other site 1224163006058 active site 1224163006059 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1224163006060 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1224163006061 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1224163006062 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 1224163006063 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1224163006064 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1224163006065 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1224163006066 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1224163006067 glutaminase; Provisional; Region: PRK00971 1224163006068 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1224163006069 anti sigma factor interaction site; other site 1224163006070 regulatory phosphorylation site [posttranslational modification]; other site 1224163006071 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1224163006072 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1224163006073 DNA binding site [nucleotide binding] 1224163006074 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1224163006075 dimerization interface [polypeptide binding]; other site 1224163006076 ligand binding site [chemical binding]; other site 1224163006077 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1224163006078 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1224163006079 tetramer interface [polypeptide binding]; other site 1224163006080 active site 1224163006081 Mg2+/Mn2+ binding site [ion binding]; other site 1224163006082 glucuronate isomerase; Reviewed; Region: PRK02925 1224163006083 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1224163006084 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1224163006085 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1224163006086 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1224163006087 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163006088 glucuronide transporter; Provisional; Region: PRK09848 1224163006089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163006090 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 1224163006091 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1224163006092 ATP-binding site [chemical binding]; other site 1224163006093 Gluconate-6-phosphate binding site [chemical binding]; other site 1224163006094 Shikimate kinase; Region: SKI; pfam01202 1224163006095 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1224163006096 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1224163006097 Isochorismatase family; Region: Isochorismatase; pfam00857 1224163006098 catalytic triad [active] 1224163006099 metal binding site [ion binding]; metal-binding site 1224163006100 conserved cis-peptide bond; other site 1224163006101 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1224163006102 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1224163006103 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1224163006104 catalytic triad [active] 1224163006105 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1224163006106 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1224163006107 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1224163006108 putative active site [active] 1224163006109 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1224163006110 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1224163006111 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1224163006112 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1224163006113 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1224163006114 active site 2 [active] 1224163006115 active site 1 [active] 1224163006116 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1224163006117 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1224163006118 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1224163006119 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1224163006120 putative NAD(P) binding site [chemical binding]; other site 1224163006121 active site 1224163006122 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1224163006123 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1224163006124 active site 1224163006125 Glucitol operon activator protein (GutM); Region: GutM; cl01890 1224163006126 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1224163006127 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1224163006128 active site 1224163006129 dimerization interface [polypeptide binding]; other site 1224163006130 ribonuclease PH; Reviewed; Region: rph; PRK00173 1224163006131 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1224163006132 hexamer interface [polypeptide binding]; other site 1224163006133 active site 1224163006134 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1224163006135 glutamate racemase; Provisional; Region: PRK00865 1224163006136 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1224163006137 MarR family; Region: MarR; pfam01047 1224163006138 Rhomboid family; Region: Rhomboid; cl11446 1224163006139 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1224163006140 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1224163006141 cleavage site 1224163006142 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1224163006143 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1224163006144 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1224163006145 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1224163006146 active site 1224163006147 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1224163006148 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1224163006149 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1224163006150 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1224163006151 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1224163006152 ligand binding site [chemical binding]; other site 1224163006153 flexible hinge region; other site 1224163006154 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1224163006155 putative switch regulator; other site 1224163006156 non-specific DNA interactions [nucleotide binding]; other site 1224163006157 DNA binding site [nucleotide binding] 1224163006158 sequence specific DNA binding site [nucleotide binding]; other site 1224163006159 putative cAMP binding site [chemical binding]; other site 1224163006160 Peptidyl-tRNA hydrolase [Translation, ribosomal structure and biogenesis]; Region: pth2; cl17334 1224163006161 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 1224163006162 dimer interface [polypeptide binding]; other site 1224163006163 putative active site [active] 1224163006164 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1224163006165 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1224163006166 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1224163006167 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1224163006168 motif II; other site 1224163006169 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1224163006170 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1224163006171 D-pathway; other site 1224163006172 Putative ubiquinol binding site [chemical binding]; other site 1224163006173 Low-spin heme (heme b) binding site [chemical binding]; other site 1224163006174 Putative water exit pathway; other site 1224163006175 Binuclear center (heme o3/CuB) [ion binding]; other site 1224163006176 K-pathway; other site 1224163006177 Putative proton exit pathway; other site 1224163006178 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1224163006179 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1224163006180 DNA-binding site [nucleotide binding]; DNA binding site 1224163006181 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1224163006182 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1224163006183 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1224163006184 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1224163006185 active site 1224163006186 dimer interface [polypeptide binding]; other site 1224163006187 catalytic residues [active] 1224163006188 effector binding site; other site 1224163006189 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1224163006190 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1224163006191 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1224163006192 catalytic residues [active] 1224163006193 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1224163006194 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1224163006195 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163006196 putative substrate translocation pore; other site 1224163006197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163006198 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1224163006199 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1224163006200 homodimer interface [polypeptide binding]; other site 1224163006201 NAD binding pocket [chemical binding]; other site 1224163006202 ATP binding pocket [chemical binding]; other site 1224163006203 Mg binding site [ion binding]; other site 1224163006204 active-site loop [active] 1224163006205 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1224163006206 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1224163006207 catalytic residues [active] 1224163006208 phosphoglucomutase; Validated; Region: PRK07564 1224163006209 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1224163006210 active site 1224163006211 substrate binding site [chemical binding]; other site 1224163006212 metal binding site [ion binding]; metal-binding site 1224163006213 CrcB-like protein; Region: CRCB; cl09114 1224163006214 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1224163006215 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1224163006216 FtsX-like permease family; Region: FtsX; pfam02687 1224163006217 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1224163006218 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1224163006219 FtsX-like permease family; Region: FtsX; pfam02687 1224163006220 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1224163006221 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1224163006222 Walker A/P-loop; other site 1224163006223 ATP binding site [chemical binding]; other site 1224163006224 Q-loop/lid; other site 1224163006225 ABC transporter signature motif; other site 1224163006226 Walker B; other site 1224163006227 D-loop; other site 1224163006228 H-loop/switch region; other site 1224163006229 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1224163006230 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1224163006231 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1224163006232 hinge; other site 1224163006233 active site 1224163006234 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1224163006235 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1224163006236 DNA binding residues [nucleotide binding] 1224163006237 dimerization interface [polypeptide binding]; other site 1224163006238 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1224163006239 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1224163006240 dimer interface [polypeptide binding]; other site 1224163006241 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1224163006242 catalytic residue [active] 1224163006243 serine O-acetyltransferase; Region: cysE; TIGR01172 1224163006244 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1224163006245 trimer interface [polypeptide binding]; other site 1224163006246 active site 1224163006247 substrate binding site [chemical binding]; other site 1224163006248 CoA binding site [chemical binding]; other site 1224163006249 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1224163006250 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1224163006251 putative homodimer interface [polypeptide binding]; other site 1224163006252 putative homotetramer interface [polypeptide binding]; other site 1224163006253 putative allosteric switch controlling residues; other site 1224163006254 putative metal binding site [ion binding]; other site 1224163006255 putative homodimer-homodimer interface [polypeptide binding]; other site 1224163006256 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1224163006257 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1224163006258 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1224163006259 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1224163006260 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1224163006261 Walker A/P-loop; other site 1224163006262 ATP binding site [chemical binding]; other site 1224163006263 Q-loop/lid; other site 1224163006264 ABC transporter signature motif; other site 1224163006265 Walker B; other site 1224163006266 D-loop; other site 1224163006267 H-loop/switch region; other site 1224163006268 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1224163006269 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1224163006270 Walker A/P-loop; other site 1224163006271 ATP binding site [chemical binding]; other site 1224163006272 Q-loop/lid; other site 1224163006273 ABC transporter signature motif; other site 1224163006274 Walker B; other site 1224163006275 D-loop; other site 1224163006276 H-loop/switch region; other site 1224163006277 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1224163006278 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1224163006279 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1224163006280 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1224163006281 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1224163006282 FMN binding site [chemical binding]; other site 1224163006283 active site 1224163006284 catalytic residues [active] 1224163006285 substrate binding site [chemical binding]; other site 1224163006286 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1224163006287 PhoU domain; Region: PhoU; pfam01895 1224163006288 PhoU domain; Region: PhoU; pfam01895 1224163006289 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1224163006290 Cytochrome P450; Region: p450; cl12078 1224163006291 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1224163006292 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1224163006293 Walker A/P-loop; other site 1224163006294 ATP binding site [chemical binding]; other site 1224163006295 Q-loop/lid; other site 1224163006296 ABC transporter signature motif; other site 1224163006297 Walker B; other site 1224163006298 D-loop; other site 1224163006299 H-loop/switch region; other site 1224163006300 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1224163006301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1224163006302 dimer interface [polypeptide binding]; other site 1224163006303 conserved gate region; other site 1224163006304 putative PBP binding loops; other site 1224163006305 ABC-ATPase subunit interface; other site 1224163006306 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1224163006307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1224163006308 dimer interface [polypeptide binding]; other site 1224163006309 conserved gate region; other site 1224163006310 putative PBP binding loops; other site 1224163006311 ABC-ATPase subunit interface; other site 1224163006312 PBP superfamily domain; Region: PBP_like_2; cl17296 1224163006313 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1224163006314 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1224163006315 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1224163006316 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1224163006317 heme-binding site [chemical binding]; other site 1224163006318 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1224163006319 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1224163006320 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1224163006321 catalytic residue [active] 1224163006322 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1224163006323 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1224163006324 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1224163006325 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1224163006326 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1224163006327 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1224163006328 dimerization interface [polypeptide binding]; other site 1224163006329 putative ATP binding site [chemical binding]; other site 1224163006330 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1224163006331 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1224163006332 active site 1224163006333 tetramer interface [polypeptide binding]; other site 1224163006334 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1224163006335 active site 1224163006336 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1224163006337 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1224163006338 LysE type translocator; Region: LysE; cl00565 1224163006339 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1224163006340 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1224163006341 putative DNA binding site [nucleotide binding]; other site 1224163006342 putative Zn2+ binding site [ion binding]; other site 1224163006343 AsnC family; Region: AsnC_trans_reg; pfam01037 1224163006344 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1224163006345 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1224163006346 dimerization interface [polypeptide binding]; other site 1224163006347 ATP binding site [chemical binding]; other site 1224163006348 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1224163006349 dimerization interface [polypeptide binding]; other site 1224163006350 ATP binding site [chemical binding]; other site 1224163006351 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1224163006352 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1224163006353 putative active site [active] 1224163006354 catalytic triad [active] 1224163006355 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1224163006356 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 1224163006357 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1224163006358 generic binding surface I; other site 1224163006359 generic binding surface II; other site 1224163006360 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 1224163006361 putative active site [active] 1224163006362 putative catalytic site [active] 1224163006363 putative Mg binding site IVb [ion binding]; other site 1224163006364 putative phosphate binding site [ion binding]; other site 1224163006365 putative DNA binding site [nucleotide binding]; other site 1224163006366 putative Mg binding site IVa [ion binding]; other site 1224163006367 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1224163006368 catalytic residues [active] 1224163006369 dimer interface [polypeptide binding]; other site 1224163006370 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 1224163006371 putative active site [active] 1224163006372 putative Zn binding site [ion binding]; other site 1224163006373 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1224163006374 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1224163006375 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1224163006376 ATP binding site [chemical binding]; other site 1224163006377 active site 1224163006378 substrate binding site [chemical binding]; other site 1224163006379 adenylosuccinate lyase; Region: purB; TIGR00928 1224163006380 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1224163006381 tetramer interface [polypeptide binding]; other site 1224163006382 aspartate aminotransferase; Provisional; Region: PRK05764 1224163006383 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1224163006384 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1224163006385 homodimer interface [polypeptide binding]; other site 1224163006386 catalytic residue [active] 1224163006387 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1224163006388 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1224163006389 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1224163006390 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1224163006391 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1224163006392 nucleotide binding site/active site [active] 1224163006393 HIT family signature motif; other site 1224163006394 catalytic residue [active] 1224163006395 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1224163006396 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1224163006397 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1224163006398 dimerization interface [polypeptide binding]; other site 1224163006399 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1224163006400 dimer interface [polypeptide binding]; other site 1224163006401 phosphorylation site [posttranslational modification] 1224163006402 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1224163006403 ATP binding site [chemical binding]; other site 1224163006404 Mg2+ binding site [ion binding]; other site 1224163006405 G-X-G motif; other site 1224163006406 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1224163006407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1224163006408 active site 1224163006409 phosphorylation site [posttranslational modification] 1224163006410 intermolecular recognition site; other site 1224163006411 dimerization interface [polypeptide binding]; other site 1224163006412 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1224163006413 DNA binding site [nucleotide binding] 1224163006414 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 1224163006415 active site 1224163006416 catalytic residues [active] 1224163006417 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1224163006418 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1224163006419 DNA binding residues [nucleotide binding] 1224163006420 dimer interface [polypeptide binding]; other site 1224163006421 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1224163006422 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 1224163006423 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1224163006424 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1224163006425 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1224163006426 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1224163006427 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1224163006428 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1224163006429 active site 1224163006430 homotetramer interface [polypeptide binding]; other site 1224163006431 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1224163006432 TIGR03086 family protein; Region: TIGR03086 1224163006433 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1224163006434 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1224163006435 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1224163006436 DNA binding site [nucleotide binding] 1224163006437 domain linker motif; other site 1224163006438 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 1224163006439 putative dimerization interface [polypeptide binding]; other site 1224163006440 putative ligand binding site [chemical binding]; other site 1224163006441 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1224163006442 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1224163006443 intersubunit interface [polypeptide binding]; other site 1224163006444 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1224163006445 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1224163006446 Walker A/P-loop; other site 1224163006447 ATP binding site [chemical binding]; other site 1224163006448 Q-loop/lid; other site 1224163006449 ABC transporter signature motif; other site 1224163006450 Walker B; other site 1224163006451 D-loop; other site 1224163006452 H-loop/switch region; other site 1224163006453 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1224163006454 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1224163006455 dimer interface [polypeptide binding]; other site 1224163006456 putative PBP binding regions; other site 1224163006457 ABC-ATPase subunit interface; other site 1224163006458 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 1224163006459 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1224163006460 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1224163006461 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1224163006462 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1224163006463 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1224163006464 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1224163006465 active site 1224163006466 HIGH motif; other site 1224163006467 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1224163006468 KMSKS motif; other site 1224163006469 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1224163006470 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1224163006471 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1224163006472 active site 1224163006473 trimer interface [polypeptide binding]; other site 1224163006474 allosteric site; other site 1224163006475 active site lid [active] 1224163006476 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1224163006477 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1224163006478 homotrimer interaction site [polypeptide binding]; other site 1224163006479 zinc binding site [ion binding]; other site 1224163006480 CDP-binding sites; other site 1224163006481 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1224163006482 substrate binding site; other site 1224163006483 dimer interface; other site 1224163006484 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1224163006485 DNA repair protein RadA; Provisional; Region: PRK11823 1224163006486 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1224163006487 Walker A motif; other site 1224163006488 ATP binding site [chemical binding]; other site 1224163006489 Walker B motif; other site 1224163006490 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1224163006491 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1224163006492 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1224163006493 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1224163006494 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1224163006495 active site clefts [active] 1224163006496 zinc binding site [ion binding]; other site 1224163006497 dimer interface [polypeptide binding]; other site 1224163006498 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1224163006499 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1224163006500 minor groove reading motif; other site 1224163006501 helix-hairpin-helix signature motif; other site 1224163006502 active site 1224163006503 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1224163006504 Predicted permeases [General function prediction only]; Region: COG0679 1224163006505 Secretory lipase; Region: LIP; pfam03583 1224163006506 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1224163006507 active site 1224163006508 metal binding site [ion binding]; metal-binding site 1224163006509 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1224163006510 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1224163006511 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1224163006512 Clp amino terminal domain; Region: Clp_N; pfam02861 1224163006513 Clp amino terminal domain; Region: Clp_N; pfam02861 1224163006514 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1224163006515 Walker A motif; other site 1224163006516 ATP binding site [chemical binding]; other site 1224163006517 Walker B motif; other site 1224163006518 arginine finger; other site 1224163006519 UvrB/uvrC motif; Region: UVR; pfam02151 1224163006520 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1224163006521 Walker A motif; other site 1224163006522 ATP binding site [chemical binding]; other site 1224163006523 Walker B motif; other site 1224163006524 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1224163006525 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1224163006526 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1224163006527 dimerization interface [polypeptide binding]; other site 1224163006528 putative DNA binding site [nucleotide binding]; other site 1224163006529 putative Zn2+ binding site [ion binding]; other site 1224163006530 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1224163006531 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1224163006532 dimer interface [polypeptide binding]; other site 1224163006533 putative anticodon binding site; other site 1224163006534 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1224163006535 motif 1; other site 1224163006536 dimer interface [polypeptide binding]; other site 1224163006537 active site 1224163006538 motif 2; other site 1224163006539 motif 3; other site 1224163006540 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1224163006541 active site 1224163006542 Protein of unknown function (DUF456); Region: DUF456; pfam04306 1224163006543 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1224163006544 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1224163006545 heme-binding site [chemical binding]; other site 1224163006546 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1224163006547 FAD binding pocket [chemical binding]; other site 1224163006548 conserved FAD binding motif [chemical binding]; other site 1224163006549 phosphate binding motif [ion binding]; other site 1224163006550 beta-alpha-beta structure motif; other site 1224163006551 NAD binding pocket [chemical binding]; other site 1224163006552 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 1224163006553 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1224163006554 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1224163006555 active site 1224163006556 nucleotide binding site [chemical binding]; other site 1224163006557 HIGH motif; other site 1224163006558 KMSKS motif; other site 1224163006559 Rossmann-like domain; Region: Rossmann-like; pfam10727 1224163006560 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1224163006561 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1224163006562 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1224163006563 catalytic center binding site [active] 1224163006564 ATP binding site [chemical binding]; other site 1224163006565 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1224163006566 homooctamer interface [polypeptide binding]; other site 1224163006567 active site 1224163006568 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1224163006569 dihydropteroate synthase; Region: DHPS; TIGR01496 1224163006570 substrate binding pocket [chemical binding]; other site 1224163006571 dimer interface [polypeptide binding]; other site 1224163006572 inhibitor binding site; inhibition site 1224163006573 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1224163006574 homodecamer interface [polypeptide binding]; other site 1224163006575 GTP cyclohydrolase I; Provisional; Region: PLN03044 1224163006576 active site 1224163006577 putative catalytic site residues [active] 1224163006578 zinc binding site [ion binding]; other site 1224163006579 GTP-CH-I/GFRP interaction surface; other site 1224163006580 FtsH Extracellular; Region: FtsH_ext; pfam06480 1224163006581 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1224163006582 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1224163006583 Walker A motif; other site 1224163006584 ATP binding site [chemical binding]; other site 1224163006585 Walker B motif; other site 1224163006586 arginine finger; other site 1224163006587 Peptidase family M41; Region: Peptidase_M41; pfam01434 1224163006588 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1224163006589 active site 1224163006590 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1224163006591 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1224163006592 Ligand Binding Site [chemical binding]; other site 1224163006593 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1224163006594 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1224163006595 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1224163006596 dimer interface [polypeptide binding]; other site 1224163006597 substrate binding site [chemical binding]; other site 1224163006598 metal binding sites [ion binding]; metal-binding site 1224163006599 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1224163006600 active site residue [active] 1224163006601 MarR family; Region: MarR_2; cl17246 1224163006602 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1224163006603 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1224163006604 acyl-activating enzyme (AAE) consensus motif; other site 1224163006605 AMP binding site [chemical binding]; other site 1224163006606 active site 1224163006607 CoA binding site [chemical binding]; other site 1224163006608 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1224163006609 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 1224163006610 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1224163006611 putative trimer interface [polypeptide binding]; other site 1224163006612 putative CoA binding site [chemical binding]; other site 1224163006613 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1224163006614 putative CoA binding site [chemical binding]; other site 1224163006615 putative trimer interface [polypeptide binding]; other site 1224163006616 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1224163006617 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1224163006618 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1224163006619 substrate binding site [chemical binding]; other site 1224163006620 oxyanion hole (OAH) forming residues; other site 1224163006621 trimer interface [polypeptide binding]; other site 1224163006622 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1224163006623 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1224163006624 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1224163006625 ring oligomerisation interface [polypeptide binding]; other site 1224163006626 ATP/Mg binding site [chemical binding]; other site 1224163006627 stacking interactions; other site 1224163006628 hinge regions; other site 1224163006629 hypothetical protein; Provisional; Region: PRK07907 1224163006630 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1224163006631 active site 1224163006632 metal binding site [ion binding]; metal-binding site 1224163006633 dimer interface [polypeptide binding]; other site 1224163006634 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 1224163006635 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1224163006636 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1224163006637 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1224163006638 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 1224163006639 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 1224163006640 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1224163006641 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1224163006642 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948 1224163006643 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12592 1224163006644 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1224163006645 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163006646 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1224163006647 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1224163006648 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 1224163006649 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1224163006650 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1224163006651 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1224163006652 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1224163006653 carboxylate-amine ligase; Provisional; Region: PRK13517 1224163006654 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1224163006655 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1224163006656 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1224163006657 MMPL family; Region: MMPL; pfam03176 1224163006658 MMPL family; Region: MMPL; pfam03176 1224163006659 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1224163006660 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1224163006661 active site 1224163006662 catalytic residues [active] 1224163006663 metal binding site [ion binding]; metal-binding site 1224163006664 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1224163006665 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1224163006666 dimer interface [polypeptide binding]; other site 1224163006667 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1224163006668 active site 1224163006669 metal binding site A [ion binding]; metal-binding site 1224163006670 DNA binding site [nucleotide binding] 1224163006671 putative catalytic site [active] 1224163006672 putative phosphate binding site [ion binding]; other site 1224163006673 putative AP binding site [nucleotide binding]; other site 1224163006674 putative metal binding site B [ion binding]; other site 1224163006675 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1224163006676 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1224163006677 putative active site [active] 1224163006678 catalytic site [active] 1224163006679 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1224163006680 putative active site [active] 1224163006681 catalytic site [active] 1224163006682 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1224163006683 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1224163006684 Walker A/P-loop; other site 1224163006685 ATP binding site [chemical binding]; other site 1224163006686 Q-loop/lid; other site 1224163006687 ABC transporter signature motif; other site 1224163006688 Walker B; other site 1224163006689 D-loop; other site 1224163006690 H-loop/switch region; other site 1224163006691 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1224163006692 nudix motif; other site 1224163006693 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1224163006694 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1224163006695 substrate binding pocket [chemical binding]; other site 1224163006696 membrane-bound complex binding site; other site 1224163006697 hinge residues; other site 1224163006698 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1224163006699 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1224163006700 active site 1224163006701 ATP binding site [chemical binding]; other site 1224163006702 substrate binding site [chemical binding]; other site 1224163006703 activation loop (A-loop); other site 1224163006704 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1224163006705 propionate/acetate kinase; Provisional; Region: PRK12379 1224163006706 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1224163006707 ferredoxin-NADP+ reductase; Region: PLN02852 1224163006708 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1224163006709 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1224163006710 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1224163006711 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1224163006712 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1224163006713 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1224163006714 ATP-grasp domain; Region: ATP-grasp; pfam02222 1224163006715 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1224163006716 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1224163006717 GDP-binding site [chemical binding]; other site 1224163006718 ACT binding site; other site 1224163006719 IMP binding site; other site 1224163006720 PRC-barrel domain; Region: PRC; pfam05239 1224163006721 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 1224163006722 Predicted membrane protein [Function unknown]; Region: COG4129 1224163006723 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1224163006724 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1224163006725 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1224163006726 active site 1224163006727 intersubunit interface [polypeptide binding]; other site 1224163006728 zinc binding site [ion binding]; other site 1224163006729 Na+ binding site [ion binding]; other site 1224163006730 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1224163006731 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1224163006732 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1224163006733 alpha-gamma subunit interface [polypeptide binding]; other site 1224163006734 beta-gamma subunit interface [polypeptide binding]; other site 1224163006735 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1224163006736 gamma-beta subunit interface [polypeptide binding]; other site 1224163006737 alpha-beta subunit interface [polypeptide binding]; other site 1224163006738 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1224163006739 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1224163006740 subunit interactions [polypeptide binding]; other site 1224163006741 active site 1224163006742 flap region; other site 1224163006743 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1224163006744 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1224163006745 dimer interface [polypeptide binding]; other site 1224163006746 catalytic residues [active] 1224163006747 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1224163006748 UreF; Region: UreF; pfam01730 1224163006749 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1224163006750 UreD urease accessory protein; Region: UreD; cl00530 1224163006751 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 1224163006752 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1224163006753 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1224163006754 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1224163006755 active site 1224163006756 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1224163006757 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1224163006758 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1224163006759 active site residue [active] 1224163006760 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1224163006761 active site residue [active] 1224163006762 Domain of unknown function (DUF4265); Region: DUF4265; pfam14085 1224163006763 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1224163006764 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1224163006765 Clp amino terminal domain; Region: Clp_N; pfam02861 1224163006766 Clp amino terminal domain; Region: Clp_N; pfam02861 1224163006767 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1224163006768 Walker A motif; other site 1224163006769 ATP binding site [chemical binding]; other site 1224163006770 Walker B motif; other site 1224163006771 arginine finger; other site 1224163006772 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1224163006773 Walker A motif; other site 1224163006774 ATP binding site [chemical binding]; other site 1224163006775 Walker B motif; other site 1224163006776 arginine finger; other site 1224163006777 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1224163006778 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1224163006779 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163006780 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 1224163006781 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1224163006782 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1224163006783 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1224163006784 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1224163006785 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1224163006786 FAD binding pocket [chemical binding]; other site 1224163006787 conserved FAD binding motif [chemical binding]; other site 1224163006788 phosphate binding motif [ion binding]; other site 1224163006789 beta-alpha-beta structure motif; other site 1224163006790 NAD binding pocket [chemical binding]; other site 1224163006791 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1224163006792 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 1224163006793 active site 1224163006794 catalytic triad [active] 1224163006795 dimer interface [polypeptide binding]; other site 1224163006796 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1224163006797 DNA binding residues [nucleotide binding] 1224163006798 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1224163006799 putative dimer interface [polypeptide binding]; other site 1224163006800 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1224163006801 HSP70 interaction site [polypeptide binding]; other site 1224163006802 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 1224163006803 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1224163006804 Zn binding sites [ion binding]; other site 1224163006805 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1224163006806 dimer interface [polypeptide binding]; other site 1224163006807 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1224163006808 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1224163006809 dimer interface [polypeptide binding]; other site 1224163006810 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1224163006811 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1224163006812 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1224163006813 nucleotide binding site [chemical binding]; other site 1224163006814 NEF interaction site [polypeptide binding]; other site 1224163006815 SBD interface [polypeptide binding]; other site 1224163006816 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1224163006817 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1224163006818 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1224163006819 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1224163006820 nucleosidase; Provisional; Region: PRK05634 1224163006821 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1224163006822 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1224163006823 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1224163006824 putative active site [active] 1224163006825 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 1224163006826 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1224163006827 CysD dimerization site [polypeptide binding]; other site 1224163006828 G1 box; other site 1224163006829 putative GEF interaction site [polypeptide binding]; other site 1224163006830 GTP/Mg2+ binding site [chemical binding]; other site 1224163006831 Switch I region; other site 1224163006832 G2 box; other site 1224163006833 G3 box; other site 1224163006834 Switch II region; other site 1224163006835 G4 box; other site 1224163006836 G5 box; other site 1224163006837 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1224163006838 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 1224163006839 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1224163006840 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1224163006841 Active Sites [active] 1224163006842 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1224163006843 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1224163006844 Active Sites [active] 1224163006845 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1224163006846 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1224163006847 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1224163006848 adrenodoxin reductase; Provisional; Region: PTZ00188 1224163006849 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1224163006850 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1224163006851 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1224163006852 Walker A/P-loop; other site 1224163006853 ATP binding site [chemical binding]; other site 1224163006854 Q-loop/lid; other site 1224163006855 ABC transporter signature motif; other site 1224163006856 Walker B; other site 1224163006857 D-loop; other site 1224163006858 H-loop/switch region; other site 1224163006859 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1224163006860 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1224163006861 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1224163006862 Walker A/P-loop; other site 1224163006863 ATP binding site [chemical binding]; other site 1224163006864 Q-loop/lid; other site 1224163006865 ABC transporter signature motif; other site 1224163006866 Walker B; other site 1224163006867 D-loop; other site 1224163006868 H-loop/switch region; other site 1224163006869 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1224163006870 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1224163006871 dimer interface [polypeptide binding]; other site 1224163006872 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1224163006873 catalytic triad [active] 1224163006874 peroxidatic and resolving cysteines [active] 1224163006875 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 1224163006876 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1224163006877 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1224163006878 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1224163006879 CoA-ligase; Region: Ligase_CoA; pfam00549 1224163006880 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1224163006881 CoA binding domain; Region: CoA_binding; smart00881 1224163006882 CoA-ligase; Region: Ligase_CoA; pfam00549 1224163006883 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1224163006884 4Fe-4S binding domain; Region: Fer4; cl02805 1224163006885 Cysteine-rich domain; Region: CCG; pfam02754 1224163006886 Cysteine-rich domain; Region: CCG; pfam02754 1224163006887 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1224163006888 aminotransferase AlaT; Validated; Region: PRK09265 1224163006889 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1224163006890 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1224163006891 homodimer interface [polypeptide binding]; other site 1224163006892 catalytic residue [active] 1224163006893 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 1224163006894 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1224163006895 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1224163006896 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1224163006897 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1224163006898 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1224163006899 trimer interface [polypeptide binding]; other site 1224163006900 active site 1224163006901 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 1224163006902 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1224163006903 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1224163006904 catalytic residue [active] 1224163006905 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1224163006906 VanW like protein; Region: VanW; pfam04294 1224163006907 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1224163006908 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1224163006909 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 1224163006910 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1224163006911 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1224163006912 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1224163006913 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1224163006914 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1224163006915 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1224163006916 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1224163006917 S-adenosylmethionine binding site [chemical binding]; other site 1224163006918 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1224163006919 active site 1224163006920 substrate-binding site [chemical binding]; other site 1224163006921 metal-binding site [ion binding] 1224163006922 GTP binding site [chemical binding]; other site 1224163006923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1224163006924 S-adenosylmethionine binding site [chemical binding]; other site 1224163006925 LabA_like proteins; Region: LabA_like; cd06167 1224163006926 putative metal binding site [ion binding]; other site 1224163006927 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1224163006928 Predicted integral membrane protein [Function unknown]; Region: COG0392 1224163006929 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1224163006930 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1224163006931 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1224163006932 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 1224163006933 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1224163006934 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1224163006935 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1224163006936 active site 1224163006937 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1224163006938 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1224163006939 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1224163006940 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1224163006941 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1224163006942 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1224163006943 acyl-activating enzyme (AAE) consensus motif; other site 1224163006944 active site 1224163006945 Cutinase; Region: Cutinase; pfam01083 1224163006946 Putative esterase; Region: Esterase; pfam00756 1224163006947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 1224163006948 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1224163006949 LGFP repeat; Region: LGFP; pfam08310 1224163006950 LGFP repeat; Region: LGFP; pfam08310 1224163006951 Predicted esterase [General function prediction only]; Region: COG0627 1224163006952 S-formylglutathione hydrolase; Region: PLN02442 1224163006953 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1224163006954 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1224163006955 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1224163006956 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1224163006957 active site 1224163006958 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1224163006959 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1224163006960 active site 1224163006961 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1224163006962 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1224163006963 UDP-galactopyranose mutase; Region: GLF; pfam03275 1224163006964 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1224163006965 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1224163006966 amidase catalytic site [active] 1224163006967 Zn binding residues [ion binding]; other site 1224163006968 substrate binding site [chemical binding]; other site 1224163006969 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1224163006970 glycerol kinase; Provisional; Region: glpK; PRK00047 1224163006971 nucleotide binding site [chemical binding]; other site 1224163006972 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1224163006973 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1224163006974 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 1224163006975 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1224163006976 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1224163006977 active site 1224163006978 motif I; other site 1224163006979 motif II; other site 1224163006980 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1224163006981 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1224163006982 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1224163006983 putative acyl-acceptor binding pocket; other site 1224163006984 seryl-tRNA synthetase; Provisional; Region: PRK05431 1224163006985 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1224163006986 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1224163006987 dimer interface [polypeptide binding]; other site 1224163006988 active site 1224163006989 motif 1; other site 1224163006990 motif 2; other site 1224163006991 motif 3; other site 1224163006992 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1224163006993 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1224163006994 DNA-binding site [nucleotide binding]; DNA binding site 1224163006995 UTRA domain; Region: UTRA; pfam07702 1224163006996 Septum formation; Region: Septum_form; pfam13845 1224163006997 Septum formation; Region: Septum_form; pfam13845 1224163006998 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1224163006999 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1224163007000 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1224163007001 catalytic core [active] 1224163007002 prephenate dehydratase; Provisional; Region: PRK11898 1224163007003 Prephenate dehydratase; Region: PDT; pfam00800 1224163007004 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1224163007005 putative L-Phe binding site [chemical binding]; other site 1224163007006 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1224163007007 Amidase; Region: Amidase; cl11426 1224163007008 CAAX protease self-immunity; Region: Abi; pfam02517 1224163007009 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1224163007010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163007011 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1224163007012 putative substrate translocation pore; other site 1224163007013 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1224163007014 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1224163007015 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1224163007016 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1224163007017 active site 1224163007018 catalytic site [active] 1224163007019 pyruvate kinase; Provisional; Region: PRK14725 1224163007020 active site 1224163007021 Predicted membrane protein [Function unknown]; Region: COG4425 1224163007022 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1224163007023 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1224163007024 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 1224163007025 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1224163007026 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1224163007027 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1224163007028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163007029 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1224163007030 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 1224163007031 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1224163007032 Lsr2; Region: Lsr2; pfam11774 1224163007033 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1224163007034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1224163007035 active site 1224163007036 phosphorylation site [posttranslational modification] 1224163007037 intermolecular recognition site; other site 1224163007038 dimerization interface [polypeptide binding]; other site 1224163007039 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1224163007040 DNA binding residues [nucleotide binding] 1224163007041 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1224163007042 Histidine kinase; Region: HisKA_3; pfam07730 1224163007043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1224163007044 ATP binding site [chemical binding]; other site 1224163007045 Mg2+ binding site [ion binding]; other site 1224163007046 G-X-G motif; other site 1224163007047 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1224163007048 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1224163007049 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1224163007050 Predicted membrane protein [Function unknown]; Region: COG2261 1224163007051 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1224163007052 Ligand Binding Site [chemical binding]; other site 1224163007053 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1224163007054 Ligand Binding Site [chemical binding]; other site 1224163007055 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1224163007056 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1224163007057 active site 1224163007058 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 1224163007059 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1224163007060 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 1224163007061 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1224163007062 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1224163007063 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1224163007064 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1224163007065 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 1224163007066 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1224163007067 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1224163007068 Walker A/P-loop; other site 1224163007069 ATP binding site [chemical binding]; other site 1224163007070 Q-loop/lid; other site 1224163007071 ABC transporter signature motif; other site 1224163007072 Walker B; other site 1224163007073 D-loop; other site 1224163007074 H-loop/switch region; other site 1224163007075 Predicted transcriptional regulators [Transcription]; Region: COG1725 1224163007076 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1224163007077 DNA-binding site [nucleotide binding]; DNA binding site 1224163007078 LabA_like proteins; Region: LabA_like; cd06167 1224163007079 putative metal binding site [ion binding]; other site 1224163007080 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1224163007081 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1224163007082 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1224163007083 catalytic residues [active] 1224163007084 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1224163007085 metal-binding site [ion binding] 1224163007086 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1224163007087 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1224163007088 metal-binding site [ion binding] 1224163007089 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1224163007090 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1224163007091 benzoate transport; Region: 2A0115; TIGR00895 1224163007092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163007093 putative substrate translocation pore; other site 1224163007094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163007095 replicative DNA helicase; Region: DnaB; TIGR00665 1224163007096 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1224163007097 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1224163007098 Walker A motif; other site 1224163007099 ATP binding site [chemical binding]; other site 1224163007100 Walker B motif; other site 1224163007101 DNA binding loops [nucleotide binding] 1224163007102 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1224163007103 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1224163007104 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1224163007105 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1224163007106 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1224163007107 dimer interface [polypeptide binding]; other site 1224163007108 ssDNA binding site [nucleotide binding]; other site 1224163007109 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1224163007110 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1224163007111 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1224163007112 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1224163007113 dimerization interface [polypeptide binding]; other site 1224163007114 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1224163007115 Predicted integral membrane protein [Function unknown]; Region: COG5650 1224163007116 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1224163007117 Transglycosylase; Region: Transgly; pfam00912 1224163007118 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1224163007119 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1224163007120 MarR family; Region: MarR; pfam01047 1224163007121 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1224163007122 Ligand Binding Site [chemical binding]; other site 1224163007123 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1224163007124 Ligand Binding Site [chemical binding]; other site 1224163007125 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1224163007126 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1224163007127 active site residue [active] 1224163007128 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 1224163007129 hypothetical protein; Provisional; Region: PRK13663 1224163007130 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1224163007131 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1224163007132 putative DNA binding site [nucleotide binding]; other site 1224163007133 catalytic residue [active] 1224163007134 putative H2TH interface [polypeptide binding]; other site 1224163007135 putative catalytic residues [active] 1224163007136 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1224163007137 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1224163007138 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 1224163007139 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1224163007140 putative substrate binding site [chemical binding]; other site 1224163007141 putative ATP binding site [chemical binding]; other site 1224163007142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1224163007143 metabolite-proton symporter; Region: 2A0106; TIGR00883 1224163007144 putative substrate translocation pore; other site 1224163007145 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1224163007146 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1224163007147 acyl-activating enzyme (AAE) consensus motif; other site 1224163007148 AMP binding site [chemical binding]; other site 1224163007149 active site 1224163007150 CoA binding site [chemical binding]; other site 1224163007151 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1224163007152 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1224163007153 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1224163007154 CoenzymeA binding site [chemical binding]; other site 1224163007155 subunit interaction site [polypeptide binding]; other site 1224163007156 PHB binding site; other site 1224163007157 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 1224163007158 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 1224163007159 Phenylacetic acid degradation B; Region: PaaB; cl01371 1224163007160 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 1224163007161 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1224163007162 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 1224163007163 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1224163007164 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1224163007165 FAD binding pocket [chemical binding]; other site 1224163007166 FAD binding motif [chemical binding]; other site 1224163007167 phosphate binding motif [ion binding]; other site 1224163007168 beta-alpha-beta structure motif; other site 1224163007169 NAD(p) ribose binding residues [chemical binding]; other site 1224163007170 NAD binding pocket [chemical binding]; other site 1224163007171 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1224163007172 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1224163007173 catalytic loop [active] 1224163007174 iron binding site [ion binding]; other site 1224163007175 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1224163007176 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1224163007177 substrate binding site [chemical binding]; other site 1224163007178 oxyanion hole (OAH) forming residues; other site 1224163007179 trimer interface [polypeptide binding]; other site 1224163007180 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1224163007181 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1224163007182 dimer interface [polypeptide binding]; other site 1224163007183 active site 1224163007184 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1224163007185 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1224163007186 substrate binding site [chemical binding]; other site 1224163007187 oxyanion hole (OAH) forming residues; other site 1224163007188 trimer interface [polypeptide binding]; other site 1224163007189 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK09260 1224163007190 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1224163007191 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1224163007192 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1224163007193 CoenzymeA binding site [chemical binding]; other site 1224163007194 subunit interaction site [polypeptide binding]; other site 1224163007195 PHB binding site; other site 1224163007196 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 1224163007197 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 1224163007198 substrate binding site [chemical binding]; other site 1224163007199 dimer interface [polypeptide binding]; other site 1224163007200 NADP binding site [chemical binding]; other site 1224163007201 catalytic residues [active] 1224163007202 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1224163007203 active site 2 [active] 1224163007204 active site 1 [active] 1224163007205 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1224163007206 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1224163007207 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1224163007208 Walker A/P-loop; other site 1224163007209 ATP binding site [chemical binding]; other site 1224163007210 Q-loop/lid; other site 1224163007211 ABC transporter signature motif; other site 1224163007212 Walker B; other site 1224163007213 D-loop; other site 1224163007214 H-loop/switch region; other site 1224163007215 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1224163007216 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1224163007217 FtsX-like permease family; Region: FtsX; pfam02687 1224163007218 potential frameshift: common BLAST hit: gi|376291492|ref|YP_005163739.1| heme-responsive histidine kinase 1224163007219 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1224163007220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1224163007221 active site 1224163007222 phosphorylation site [posttranslational modification] 1224163007223 intermolecular recognition site; other site 1224163007224 dimerization interface [polypeptide binding]; other site 1224163007225 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1224163007226 DNA binding residues [nucleotide binding] 1224163007227 dimerization interface [polypeptide binding]; other site 1224163007228 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1224163007229 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1224163007230 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1224163007231 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1224163007232 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1224163007233 N- and C-terminal domain interface [polypeptide binding]; other site 1224163007234 active site 1224163007235 catalytic site [active] 1224163007236 metal binding site [ion binding]; metal-binding site 1224163007237 carbohydrate binding site [chemical binding]; other site 1224163007238 ATP binding site [chemical binding]; other site 1224163007239 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1224163007240 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1224163007241 NAD binding site [chemical binding]; other site 1224163007242 substrate binding site [chemical binding]; other site 1224163007243 putative active site [active] 1224163007244 Predicted membrane protein [Function unknown]; Region: COG2149 1224163007245 VanZ like family; Region: VanZ; cl01971 1224163007246 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1224163007247 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1224163007248 NADP binding site [chemical binding]; other site 1224163007249 dimer interface [polypeptide binding]; other site 1224163007250 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1224163007251 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1224163007252 active site 1224163007253 HIGH motif; other site 1224163007254 nucleotide binding site [chemical binding]; other site 1224163007255 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1224163007256 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1224163007257 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1224163007258 active site 1224163007259 KMSKS motif; other site 1224163007260 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1224163007261 tRNA binding surface [nucleotide binding]; other site 1224163007262 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1224163007263 pentamer interface [polypeptide binding]; other site 1224163007264 dodecaamer interface [polypeptide binding]; other site 1224163007265 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1224163007266 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1224163007267 NAD(P) binding site [chemical binding]; other site 1224163007268 catalytic residues [active] 1224163007269 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1224163007270 PAS domain; Region: PAS_9; pfam13426 1224163007271 putative active site [active] 1224163007272 heme pocket [chemical binding]; other site 1224163007273 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1224163007274 succinic semialdehyde dehydrogenase; Region: PLN02278 1224163007275 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1224163007276 tetramerization interface [polypeptide binding]; other site 1224163007277 NAD(P) binding site [chemical binding]; other site 1224163007278 catalytic residues [active] 1224163007279 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1224163007280 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1224163007281 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1224163007282 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1224163007283 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1224163007284 SdpI/YhfL protein family; Region: SdpI; pfam13630 1224163007285 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1224163007286 anthranilate synthase component I; Provisional; Region: PRK13564 1224163007287 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1224163007288 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1224163007289 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1224163007290 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1224163007291 glutamine binding [chemical binding]; other site 1224163007292 catalytic triad [active] 1224163007293 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1224163007294 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1224163007295 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1224163007296 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1224163007297 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1224163007298 active site 1224163007299 ribulose/triose binding site [chemical binding]; other site 1224163007300 phosphate binding site [ion binding]; other site 1224163007301 substrate (anthranilate) binding pocket [chemical binding]; other site 1224163007302 product (indole) binding pocket [chemical binding]; other site 1224163007303 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1224163007304 active site 1224163007305 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1224163007306 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1224163007307 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1224163007308 catalytic residue [active] 1224163007309 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1224163007310 substrate binding site [chemical binding]; other site 1224163007311 active site 1224163007312 catalytic residues [active] 1224163007313 heterodimer interface [polypeptide binding]; other site 1224163007314 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1224163007315 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1224163007316 Walker A/P-loop; other site 1224163007317 ATP binding site [chemical binding]; other site 1224163007318 Q-loop/lid; other site 1224163007319 ABC transporter signature motif; other site 1224163007320 Walker B; other site 1224163007321 D-loop; other site 1224163007322 H-loop/switch region; other site 1224163007323 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1224163007324 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1224163007325 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1224163007326 active site 1224163007327 FMN binding site [chemical binding]; other site 1224163007328 substrate binding site [chemical binding]; other site 1224163007329 homotetramer interface [polypeptide binding]; other site 1224163007330 catalytic residue [active] 1224163007331 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1224163007332 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1224163007333 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1224163007334 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1224163007335 AzlC protein; Region: AzlC; cl00570 1224163007336 hypothetical protein; Validated; Region: PRK00228 1224163007337 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1224163007338 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1224163007339 active site 1224163007340 NTP binding site [chemical binding]; other site 1224163007341 metal binding triad [ion binding]; metal-binding site 1224163007342 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1224163007343 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1224163007344 Zn2+ binding site [ion binding]; other site 1224163007345 Mg2+ binding site [ion binding]; other site 1224163007346 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1224163007347 active site 1224163007348 Ap6A binding site [chemical binding]; other site 1224163007349 nudix motif; other site 1224163007350 metal binding site [ion binding]; metal-binding site 1224163007351 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1224163007352 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1224163007353 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1224163007354 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1224163007355 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1224163007356 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1224163007357 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1224163007358 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1224163007359 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1224163007360 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1224163007361 catalytic residues [active] 1224163007362 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1224163007363 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1224163007364 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1224163007365 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1224163007366 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1224163007367 active site 1224163007368 metal binding site [ion binding]; metal-binding site 1224163007369 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1224163007370 ParB-like nuclease domain; Region: ParBc; pfam02195 1224163007371 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1224163007372 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1224163007373 P-loop; other site 1224163007374 Magnesium ion binding site [ion binding]; other site 1224163007375 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1224163007376 Magnesium ion binding site [ion binding]; other site 1224163007377 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1224163007378 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1224163007379 S-adenosylmethionine binding site [chemical binding]; other site 1224163007380 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1224163007381 Haemolytic domain; Region: Haemolytic; pfam01809 1224163007382 Ribonuclease P; Region: Ribonuclease_P; cl00457 1224163007383 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1224163007384 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1224163007385 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1224163007386 P-loop; other site 1224163007387 Magnesium ion binding site [ion binding]; other site 1224163007388 Lsr2; Region: Lsr2; pfam11774 1224163007389 HicB family; Region: HicB; pfam05534 1224163007390 ParA-like protein; Provisional; Region: PHA02518 1224163007391 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1224163007392 P-loop; other site 1224163007393 Magnesium ion binding site [ion binding]; other site 1224163007394 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1224163007395 Probable transposase; Region: OrfB_IS605; pfam01385 1224163007396 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1224163007397 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1224163007398 Replicase family; Region: Replicase; pfam03090 1224163007399 HTH domain; Region: HTH_11; cl17392 1224163007400 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 1224163007401 Replicase family; Region: Replicase; pfam03090 1224163007402 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1224163007403 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1224163007404 catalytic residues [active] 1224163007405 catalytic nucleophile [active] 1224163007406 Presynaptic Site I dimer interface [polypeptide binding]; other site 1224163007407 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1224163007408 Synaptic Flat tetramer interface [polypeptide binding]; other site 1224163007409 Synaptic Site I dimer interface [polypeptide binding]; other site 1224163007410 DNA binding site [nucleotide binding] 1224163007411 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1224163007412 DNA-binding interface [nucleotide binding]; DNA binding site 1224163007413 mercuric reductase; Region: MerA; TIGR02053 1224163007414 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1224163007415 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1224163007416 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1224163007417 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1224163007418 DNA binding residues [nucleotide binding] 1224163007419 dimer interface [polypeptide binding]; other site 1224163007420 metal binding site [ion binding]; metal-binding site 1224163007421 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1224163007422 dimerization interface [polypeptide binding]; other site 1224163007423 putative DNA binding site [nucleotide binding]; other site 1224163007424 putative Zn2+ binding site [ion binding]; other site 1224163007425 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1224163007426 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1224163007427 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1224163007428 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1224163007429 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1224163007430 active site 1224163007431 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1224163007432 arsenical-resistance protein; Region: acr3; TIGR00832 1224163007433 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1224163007434 dimerization interface [polypeptide binding]; other site 1224163007435 putative DNA binding site [nucleotide binding]; other site 1224163007436 putative Zn2+ binding site [ion binding]; other site 1224163007437 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1224163007438 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1224163007439 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1224163007440 Integrase core domain; Region: rve; pfam00665 1224163007441 HTH-like domain; Region: HTH_21; pfam13276 1224163007442 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1224163007443 Transposase; Region: HTH_Tnp_1; pfam01527 1224163007444 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1224163007445 TrwC relaxase; Region: TrwC; pfam08751 1224163007446 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 1224163007447 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1224163007448 putative DNA binding site [nucleotide binding]; other site 1224163007449 dimerization interface [polypeptide binding]; other site 1224163007450 putative Zn2+ binding site [ion binding]; other site 1224163007451 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1224163007452 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1224163007453 Walker A/P-loop; other site 1224163007454 ATP binding site [chemical binding]; other site 1224163007455 Q-loop/lid; other site 1224163007456 ABC transporter signature motif; other site 1224163007457 Walker B; other site 1224163007458 D-loop; other site 1224163007459 H-loop/switch region; other site 1224163007460 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1224163007461 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1224163007462 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1224163007463 Walker A/P-loop; other site 1224163007464 ATP binding site [chemical binding]; other site 1224163007465 Q-loop/lid; other site 1224163007466 ABC transporter signature motif; other site 1224163007467 Walker B; other site 1224163007468 D-loop; other site 1224163007469 H-loop/switch region; other site 1224163007470 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316