-- dump date 20140619_052030 -- class Genbank::misc_feature -- table misc_feature_note -- id note 679896000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 679896000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 679896000003 Walker A motif; other site 679896000004 ATP binding site [chemical binding]; other site 679896000005 Walker B motif; other site 679896000006 arginine finger; other site 679896000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 679896000008 DnaA box-binding interface [nucleotide binding]; other site 679896000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 679896000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 679896000011 putative DNA binding surface [nucleotide binding]; other site 679896000012 dimer interface [polypeptide binding]; other site 679896000013 beta-clamp/clamp loader binding surface; other site 679896000014 beta-clamp/translesion DNA polymerase binding surface; other site 679896000015 recombination protein F; Reviewed; Region: recF; PRK00064 679896000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 679896000017 Walker A/P-loop; other site 679896000018 ATP binding site [chemical binding]; other site 679896000019 Q-loop/lid; other site 679896000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 679896000021 ABC transporter signature motif; other site 679896000022 Walker B; other site 679896000023 D-loop; other site 679896000024 H-loop/switch region; other site 679896000025 hypothetical protein; Provisional; Region: PRK00111 679896000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 679896000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 679896000028 ATP binding site [chemical binding]; other site 679896000029 Mg2+ binding site [ion binding]; other site 679896000030 G-X-G motif; other site 679896000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 679896000032 anchoring element; other site 679896000033 dimer interface [polypeptide binding]; other site 679896000034 ATP binding site [chemical binding]; other site 679896000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 679896000036 active site 679896000037 putative metal-binding site [ion binding]; other site 679896000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 679896000039 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 679896000040 metal binding site [ion binding]; metal-binding site 679896000041 DNA gyrase subunit A; Validated; Region: PRK05560 679896000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 679896000043 CAP-like domain; other site 679896000044 active site 679896000045 primary dimer interface [polypeptide binding]; other site 679896000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 679896000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 679896000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 679896000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 679896000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 679896000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 679896000052 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 679896000053 YwiC-like protein; Region: YwiC; pfam14256 679896000054 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 679896000055 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 679896000056 putative ligand binding site [chemical binding]; other site 679896000057 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 679896000058 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 679896000059 TM-ABC transporter signature motif; other site 679896000060 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 679896000061 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 679896000062 Walker A/P-loop; other site 679896000063 ATP binding site [chemical binding]; other site 679896000064 Q-loop/lid; other site 679896000065 ABC transporter signature motif; other site 679896000066 Walker B; other site 679896000067 D-loop; other site 679896000068 H-loop/switch region; other site 679896000069 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 679896000070 active site 679896000071 Rhomboid family; Region: Rhomboid; pfam01694 679896000072 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cl17348 679896000073 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 679896000074 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 679896000075 Glycerophosphodiester phosphodiesterase-like domain of spider venom sphingomyelinases D, bacterial phospholipase D, and similar proteins; Region: GDPD_like_SMaseD_PLD; cd08576 679896000076 putative active site [active] 679896000077 catalytic site [active] 679896000078 Mg binding site [ion binding]; other site 679896000079 catalytic loop [active] 679896000080 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 679896000081 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 679896000082 Walker A/P-loop; other site 679896000083 ATP binding site [chemical binding]; other site 679896000084 Q-loop/lid; other site 679896000085 ABC transporter signature motif; other site 679896000086 Walker B; other site 679896000087 D-loop; other site 679896000088 H-loop/switch region; other site 679896000089 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 679896000090 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 679896000091 ABC-ATPase subunit interface; other site 679896000092 dimer interface [polypeptide binding]; other site 679896000093 putative PBP binding regions; other site 679896000094 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 679896000095 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 679896000096 ABC-ATPase subunit interface; other site 679896000097 dimer interface [polypeptide binding]; other site 679896000098 putative PBP binding regions; other site 679896000099 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 679896000100 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 679896000101 siderophore binding site; other site 679896000102 putative septation inhibitor protein; Reviewed; Region: PRK00159 679896000103 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 679896000104 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 679896000105 active site 679896000106 ATP binding site [chemical binding]; other site 679896000107 substrate binding site [chemical binding]; other site 679896000108 activation loop (A-loop); other site 679896000109 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 679896000110 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 679896000111 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 679896000112 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 679896000113 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 679896000114 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 679896000115 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 679896000116 active site 679896000117 ATP binding site [chemical binding]; other site 679896000118 substrate binding site [chemical binding]; other site 679896000119 activation loop (A-loop); other site 679896000120 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 679896000121 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 679896000122 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 679896000123 Protein phosphatase 2C; Region: PP2C; pfam00481 679896000124 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 679896000125 active site 679896000126 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 679896000127 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 679896000128 phosphopeptide binding site; other site 679896000129 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 679896000130 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 679896000131 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 679896000132 phosphopeptide binding site; other site 679896000133 CAAX protease self-immunity; Region: Abi; pfam02517 679896000134 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 679896000135 Predicted transcriptional regulators [Transcription]; Region: COG1695 679896000136 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 679896000137 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 679896000138 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 679896000139 intersubunit interface [polypeptide binding]; other site 679896000140 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 679896000141 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 679896000142 Walker A/P-loop; other site 679896000143 ATP binding site [chemical binding]; other site 679896000144 Q-loop/lid; other site 679896000145 ABC transporter signature motif; other site 679896000146 Walker B; other site 679896000147 D-loop; other site 679896000148 H-loop/switch region; other site 679896000149 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 679896000150 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 679896000151 ABC-ATPase subunit interface; other site 679896000152 dimer interface [polypeptide binding]; other site 679896000153 putative PBP binding regions; other site 679896000154 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 679896000155 MgtE intracellular N domain; Region: MgtE_N; smart00924 679896000156 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 679896000157 Divalent cation transporter; Region: MgtE; pfam01769 679896000158 trehalose synthase; Region: treS_nterm; TIGR02456 679896000159 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_2; cd11348 679896000160 active site 679896000161 catalytic site [active] 679896000162 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 679896000163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 679896000164 Major Facilitator Superfamily; Region: MFS_1; pfam07690 679896000165 putative substrate translocation pore; other site 679896000166 Anti-sigma-K factor rskA; Region: RskA; pfam10099 679896000167 RNA polymerase sigma factor; Provisional; Region: PRK12537 679896000168 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 679896000169 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 679896000170 DNA binding residues [nucleotide binding] 679896000171 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 679896000172 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 679896000173 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 679896000174 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 679896000175 catalytic residues [active] 679896000176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 679896000177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 679896000178 dimer interface [polypeptide binding]; other site 679896000179 conserved gate region; other site 679896000180 putative PBP binding loops; other site 679896000181 ABC-ATPase subunit interface; other site 679896000182 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 679896000183 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 679896000184 Walker A/P-loop; other site 679896000185 ATP binding site [chemical binding]; other site 679896000186 Q-loop/lid; other site 679896000187 ABC transporter signature motif; other site 679896000188 Walker B; other site 679896000189 D-loop; other site 679896000190 H-loop/switch region; other site 679896000191 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 679896000192 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 679896000193 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 679896000194 putative metal binding site [ion binding]; other site 679896000195 biotin synthase; Validated; Region: PRK06256 679896000196 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 679896000197 FeS/SAM binding site; other site 679896000198 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 679896000199 MepB protein; Region: MepB; cl01985 679896000200 AMP nucleosidase; Provisional; Region: PRK08292 679896000201 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 679896000202 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 679896000203 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 679896000204 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 679896000205 active site 679896000206 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 679896000207 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 679896000208 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 679896000209 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 679896000210 Lipase (class 2); Region: Lipase_2; pfam01674 679896000211 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370 679896000212 dimer interface [polypeptide binding]; other site 679896000213 FMN binding site [chemical binding]; other site 679896000214 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 679896000215 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 679896000216 trimer interface [polypeptide binding]; other site 679896000217 putative metal binding site [ion binding]; other site 679896000218 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 679896000219 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 679896000220 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 679896000221 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 679896000222 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 679896000223 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 679896000224 Coenzyme A binding pocket [chemical binding]; other site 679896000225 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 679896000226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805 679896000227 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 679896000228 MarR family; Region: MarR; pfam01047 679896000229 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 679896000230 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 679896000231 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 679896000232 hypothetical protein; Provisional; Region: PRK10621 679896000233 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 679896000234 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 679896000235 active site 679896000236 phosphorylation site [posttranslational modification] 679896000237 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 679896000238 active site 679896000239 P-loop; other site 679896000240 phosphorylation site [posttranslational modification] 679896000241 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 679896000242 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 679896000243 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 679896000244 ATP binding site [chemical binding]; other site 679896000245 putative Mg++ binding site [ion binding]; other site 679896000246 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 679896000247 nucleotide binding region [chemical binding]; other site 679896000248 ATP-binding site [chemical binding]; other site 679896000249 Helicase associated domain (HA2); Region: HA2; pfam04408 679896000250 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 679896000251 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 679896000252 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 679896000253 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 679896000254 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 679896000255 NAD(P) binding site [chemical binding]; other site 679896000256 active site 679896000257 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 679896000258 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 679896000259 RNA binding surface [nucleotide binding]; other site 679896000260 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 679896000261 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 679896000262 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 679896000263 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 679896000264 DNA binding site [nucleotide binding] 679896000265 active site 679896000266 Domain of unknown function (DUF222); Region: DUF222; pfam02720 679896000267 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 679896000268 active site 679896000269 glycerol kinase; Provisional; Region: glpK; PRK00047 679896000270 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 679896000271 nucleotide binding site [chemical binding]; other site 679896000272 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 679896000273 amphipathic channel; other site 679896000274 Asn-Pro-Ala signature motifs; other site 679896000275 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 679896000276 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 679896000277 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 679896000278 active site 679896000279 Zn binding site [ion binding]; other site 679896000280 Protease prsW family; Region: PrsW-protease; pfam13367 679896000281 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 679896000282 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 679896000283 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 679896000284 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 679896000285 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 679896000286 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 679896000287 classical (c) SDRs; Region: SDR_c; cd05233 679896000288 NAD(P) binding site [chemical binding]; other site 679896000289 active site 679896000290 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 679896000291 FAD binding domain; Region: FAD_binding_4; pfam01565 679896000292 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 679896000293 Predicted membrane protein [Function unknown]; Region: COG2246 679896000294 GtrA-like protein; Region: GtrA; pfam04138 679896000295 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 679896000296 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 679896000297 active site 679896000298 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 679896000299 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 679896000300 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 679896000301 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 679896000302 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 679896000303 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 679896000304 ABC-ATPase subunit interface; other site 679896000305 dimer interface [polypeptide binding]; other site 679896000306 putative PBP binding regions; other site 679896000307 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 679896000308 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 679896000309 intersubunit interface [polypeptide binding]; other site 679896000310 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 679896000311 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 679896000312 active site 679896000313 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 679896000314 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 679896000315 Walker A/P-loop; other site 679896000316 ATP binding site [chemical binding]; other site 679896000317 Q-loop/lid; other site 679896000318 ABC transporter signature motif; other site 679896000319 Walker B; other site 679896000320 D-loop; other site 679896000321 H-loop/switch region; other site 679896000322 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 679896000323 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 679896000324 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 679896000325 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 679896000326 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 679896000327 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 679896000328 NAD(P) binding site [chemical binding]; other site 679896000329 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 679896000330 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 679896000331 pyridoxal 5'-phosphate binding site [chemical binding]; other site 679896000332 homodimer interface [polypeptide binding]; other site 679896000333 catalytic residue [active] 679896000334 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 679896000335 transmembrane helices; other site 679896000336 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 679896000337 CAT RNA binding domain; Region: CAT_RBD; smart01061 679896000338 PRD domain; Region: PRD; pfam00874 679896000339 PRD domain; Region: PRD; pfam00874 679896000340 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 679896000341 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 679896000342 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 679896000343 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 679896000344 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 679896000345 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 679896000346 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 679896000347 DNA-binding site [nucleotide binding]; DNA binding site 679896000348 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 679896000349 pyridoxal 5'-phosphate binding site [chemical binding]; other site 679896000350 homodimer interface [polypeptide binding]; other site 679896000351 catalytic residue [active] 679896000352 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 679896000353 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 679896000354 active site 679896000355 multimer interface [polypeptide binding]; other site 679896000356 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 679896000357 predicted active site [active] 679896000358 catalytic triad [active] 679896000359 prephenate dehydrogenase; Validated; Region: PRK06545 679896000360 prephenate dehydrogenase; Validated; Region: PRK08507 679896000361 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 679896000362 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 679896000363 nucleoside/Zn binding site; other site 679896000364 dimer interface [polypeptide binding]; other site 679896000365 catalytic motif [active] 679896000366 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 679896000367 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 679896000368 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 679896000369 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 679896000370 active site 679896000371 KMSKS motif; other site 679896000372 fructuronate transporter; Provisional; Region: PRK10034; cl15264 679896000373 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 679896000374 Shikimate kinase; Region: SKI; pfam01202 679896000375 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 679896000376 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 679896000377 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 679896000378 putative NAD(P) binding site [chemical binding]; other site 679896000379 catalytic Zn binding site [ion binding]; other site 679896000380 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 679896000381 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 679896000382 NADP binding site [chemical binding]; other site 679896000383 homodimer interface [polypeptide binding]; other site 679896000384 active site 679896000385 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 679896000386 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 679896000387 pyridoxal 5'-phosphate binding site [chemical binding]; other site 679896000388 homodimer interface [polypeptide binding]; other site 679896000389 catalytic residue [active] 679896000390 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 679896000391 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 679896000392 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 679896000393 Walker A motif; other site 679896000394 ATP binding site [chemical binding]; other site 679896000395 Walker B motif; other site 679896000396 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 679896000397 arginine finger; other site 679896000398 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 679896000399 hypothetical protein; Validated; Region: PRK00153 679896000400 recombination protein RecR; Reviewed; Region: recR; PRK00076 679896000401 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 679896000402 RecR protein; Region: RecR; pfam02132 679896000403 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 679896000404 putative active site [active] 679896000405 putative metal-binding site [ion binding]; other site 679896000406 tetramer interface [polypeptide binding]; other site 679896000407 putative transporter; Provisional; Region: PRK09821 679896000408 GntP family permease; Region: GntP_permease; pfam02447 679896000409 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 679896000410 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 679896000411 Transcriptional regulators [Transcription]; Region: FadR; COG2186 679896000412 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 679896000413 DNA-binding site [nucleotide binding]; DNA binding site 679896000414 FCD domain; Region: FCD; pfam07729 679896000415 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 679896000416 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 679896000417 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 679896000418 catalytic triad [active] 679896000419 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 679896000420 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 679896000421 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 679896000422 DNA polymerase III subunit epsilon; Validated; Region: PRK05601 679896000423 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 679896000424 active site 679896000425 catalytic site [active] 679896000426 substrate binding site [chemical binding]; other site 679896000427 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 679896000428 2-isopropylmalate synthase; Validated; Region: PRK03739 679896000429 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 679896000430 active site 679896000431 catalytic residues [active] 679896000432 metal binding site [ion binding]; metal-binding site 679896000433 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 679896000434 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 679896000435 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 679896000436 DNA binding residues [nucleotide binding] 679896000437 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 679896000438 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 679896000439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 679896000440 Major Facilitator Superfamily; Region: MFS_1; pfam07690 679896000441 putative substrate translocation pore; other site 679896000442 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 679896000443 intersubunit interface [polypeptide binding]; other site 679896000444 active site 679896000445 catalytic residue [active] 679896000446 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 679896000447 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 679896000448 active site 679896000449 substrate binding site [chemical binding]; other site 679896000450 metal binding site [ion binding]; metal-binding site 679896000451 TQXA domain; Region: TQXA_dom; TIGR03934 679896000452 Cna protein B-type domain; Region: Cna_B; pfam05738 679896000453 Cna protein B-type domain; Region: Cna_B; pfam05738 679896000454 Cna protein B-type domain; Region: Cna_B; pfam05738 679896000455 aspartate kinase; Reviewed; Region: PRK06635 679896000456 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 679896000457 putative nucleotide binding site [chemical binding]; other site 679896000458 putative catalytic residues [active] 679896000459 putative Mg ion binding site [ion binding]; other site 679896000460 putative aspartate binding site [chemical binding]; other site 679896000461 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 679896000462 putative allosteric regulatory site; other site 679896000463 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 679896000464 putative allosteric regulatory residue; other site 679896000465 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 679896000466 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 679896000467 RNA polymerase sigma factor; Provisional; Region: PRK12535 679896000468 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 679896000469 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 679896000470 DNA binding residues [nucleotide binding] 679896000471 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 679896000472 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 679896000473 heme binding pocket [chemical binding]; other site 679896000474 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 679896000475 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 679896000476 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 679896000477 Walker A/P-loop; other site 679896000478 ATP binding site [chemical binding]; other site 679896000479 Q-loop/lid; other site 679896000480 ABC transporter signature motif; other site 679896000481 Walker B; other site 679896000482 D-loop; other site 679896000483 H-loop/switch region; other site 679896000484 TOBE domain; Region: TOBE_2; pfam08402 679896000485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 679896000486 dimer interface [polypeptide binding]; other site 679896000487 conserved gate region; other site 679896000488 ABC-ATPase subunit interface; other site 679896000489 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 679896000490 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 679896000491 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 679896000492 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 679896000493 putative substrate translocation pore; other site 679896000494 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 679896000495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 679896000496 active site 679896000497 phosphorylation site [posttranslational modification] 679896000498 intermolecular recognition site; other site 679896000499 dimerization interface [polypeptide binding]; other site 679896000500 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 679896000501 DNA binding site [nucleotide binding] 679896000502 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 679896000503 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 679896000504 dimer interface [polypeptide binding]; other site 679896000505 phosphorylation site [posttranslational modification] 679896000506 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 679896000507 ATP binding site [chemical binding]; other site 679896000508 Mg2+ binding site [ion binding]; other site 679896000509 G-X-G motif; other site 679896000510 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 679896000511 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612 679896000512 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654 679896000513 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 679896000514 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 679896000515 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 679896000516 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 679896000517 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 679896000518 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 679896000519 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 679896000520 Predicted membrane protein [Function unknown]; Region: COG1511 679896000521 Predicted membrane protein [Function unknown]; Region: COG1511 679896000522 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 679896000523 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 679896000524 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 679896000525 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 679896000526 Walker A/P-loop; other site 679896000527 ATP binding site [chemical binding]; other site 679896000528 Q-loop/lid; other site 679896000529 ABC transporter signature motif; other site 679896000530 Walker B; other site 679896000531 D-loop; other site 679896000532 H-loop/switch region; other site 679896000533 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 679896000534 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 679896000535 putative active site [active] 679896000536 putative metal binding site [ion binding]; other site 679896000537 Yqey-like protein; Region: YqeY; pfam09424 679896000538 Transglycosylase; Region: Transgly; pfam00912 679896000539 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 679896000540 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 679896000541 PASTA domain; Region: PASTA; pfam03793 679896000542 Transcription factor WhiB; Region: Whib; pfam02467 679896000543 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 679896000544 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 679896000545 homotrimer interaction site [polypeptide binding]; other site 679896000546 putative active site [active] 679896000547 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 679896000548 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 679896000549 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 679896000550 ligand binding site [chemical binding]; other site 679896000551 flexible hinge region; other site 679896000552 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 679896000553 putative switch regulator; other site 679896000554 non-specific DNA interactions [nucleotide binding]; other site 679896000555 DNA binding site [nucleotide binding] 679896000556 sequence specific DNA binding site [nucleotide binding]; other site 679896000557 putative cAMP binding site [chemical binding]; other site 679896000558 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 679896000559 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 679896000560 minor groove reading motif; other site 679896000561 helix-hairpin-helix signature motif; other site 679896000562 substrate binding pocket [chemical binding]; other site 679896000563 active site 679896000564 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 679896000565 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 679896000566 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 679896000567 catalytic residues [active] 679896000568 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 679896000569 putative active site [active] 679896000570 putative CoA binding site [chemical binding]; other site 679896000571 nudix motif; other site 679896000572 metal binding site [ion binding]; metal-binding site 679896000573 Colicin V production protein; Region: Colicin_V; pfam02674 679896000574 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 679896000575 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 679896000576 active site 679896000577 substrate binding sites [chemical binding]; other site 679896000578 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 679896000579 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 679896000580 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 679896000581 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 679896000582 motif II; other site 679896000583 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 679896000584 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 679896000585 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 679896000586 ATP binding site [chemical binding]; other site 679896000587 Walker A motif; other site 679896000588 hexamer interface [polypeptide binding]; other site 679896000589 Walker B motif; other site 679896000590 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 679896000591 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 679896000592 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 679896000593 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 679896000594 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 679896000595 ATP binding site [chemical binding]; other site 679896000596 putative Mg++ binding site [ion binding]; other site 679896000597 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 679896000598 nucleotide binding region [chemical binding]; other site 679896000599 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 679896000600 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 679896000601 DNA-binding site [nucleotide binding]; DNA binding site 679896000602 RNA-binding motif; other site 679896000603 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 679896000604 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 679896000605 active site 679896000606 interdomain interaction site; other site 679896000607 putative metal-binding site [ion binding]; other site 679896000608 nucleotide binding site [chemical binding]; other site 679896000609 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 679896000610 domain I; other site 679896000611 DNA binding groove [nucleotide binding] 679896000612 phosphate binding site [ion binding]; other site 679896000613 domain II; other site 679896000614 domain III; other site 679896000615 nucleotide binding site [chemical binding]; other site 679896000616 catalytic site [active] 679896000617 domain IV; other site 679896000618 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 679896000619 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 679896000620 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 679896000621 Predicted membrane protein [Function unknown]; Region: COG1297 679896000622 putative oligopeptide transporter, OPT family; Region: TIGR00733 679896000623 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 679896000624 dimerization interface [polypeptide binding]; other site 679896000625 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 679896000626 cyclase homology domain; Region: CHD; cd07302 679896000627 nucleotidyl binding site; other site 679896000628 metal binding site [ion binding]; metal-binding site 679896000629 dimer interface [polypeptide binding]; other site 679896000630 DNA polymerase III subunit delta'; Validated; Region: PRK07940 679896000631 DNA polymerase III subunit delta'; Validated; Region: PRK08485 679896000632 acyl-CoA synthetase; Validated; Region: PRK07788 679896000633 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 679896000634 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 679896000635 acyl-activating enzyme (AAE) consensus motif; other site 679896000636 acyl-activating enzyme (AAE) consensus motif; other site 679896000637 AMP binding site [chemical binding]; other site 679896000638 active site 679896000639 CoA binding site [chemical binding]; other site 679896000640 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 679896000641 active site 679896000642 catalytic triad [active] 679896000643 oxyanion hole [active] 679896000644 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 679896000645 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 679896000646 substrate binding site; other site 679896000647 tetramer interface; other site 679896000648 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 679896000649 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 679896000650 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 679896000651 NADP binding site [chemical binding]; other site 679896000652 active site 679896000653 putative substrate binding site [chemical binding]; other site 679896000654 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 679896000655 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 679896000656 NAD binding site [chemical binding]; other site 679896000657 substrate binding site [chemical binding]; other site 679896000658 homodimer interface [polypeptide binding]; other site 679896000659 active site 679896000660 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 679896000661 Zn binding site [ion binding]; other site 679896000662 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 679896000663 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 679896000664 Putative esterase; Region: Esterase; pfam00756 679896000665 Peptidase family S64; Region: Peptidase_S64; pfam08192 679896000666 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 679896000667 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 679896000668 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 679896000669 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 679896000670 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 679896000671 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 679896000672 non-specific DNA binding site [nucleotide binding]; other site 679896000673 salt bridge; other site 679896000674 sequence-specific DNA binding site [nucleotide binding]; other site 679896000675 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 679896000676 Domain of unknown function (DUF955); Region: DUF955; pfam06114 679896000677 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 679896000678 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 679896000679 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 679896000680 putative Iron-sulfur protein interface [polypeptide binding]; other site 679896000681 proximal heme binding site [chemical binding]; other site 679896000682 distal heme binding site [chemical binding]; other site 679896000683 putative dimer interface [polypeptide binding]; other site 679896000684 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 679896000685 L-aspartate oxidase; Provisional; Region: PRK06175 679896000686 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 679896000687 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 679896000688 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 679896000689 Predicted membrane protein [Function unknown]; Region: COG2733 679896000690 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 679896000691 Class I aldolases; Region: Aldolase_Class_I; cl17187 679896000692 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 679896000693 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 679896000694 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 679896000695 FeS/SAM binding site; other site 679896000696 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 679896000697 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 679896000698 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 679896000699 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 679896000700 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 679896000701 FAD binding domain; Region: FAD_binding_4; pfam01565 679896000702 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 679896000703 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 679896000704 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 679896000705 acyl-activating enzyme (AAE) consensus motif; other site 679896000706 putative AMP binding site [chemical binding]; other site 679896000707 putative active site [active] 679896000708 putative CoA binding site [chemical binding]; other site 679896000709 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 679896000710 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 679896000711 putative ADP-binding pocket [chemical binding]; other site 679896000712 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 679896000713 catalytic core [active] 679896000714 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 679896000715 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 679896000716 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 679896000717 dimer interface [polypeptide binding]; other site 679896000718 phosphorylation site [posttranslational modification] 679896000719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 679896000720 ATP binding site [chemical binding]; other site 679896000721 Mg2+ binding site [ion binding]; other site 679896000722 G-X-G motif; other site 679896000723 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 679896000724 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 679896000725 active site 679896000726 phosphorylation site [posttranslational modification] 679896000727 intermolecular recognition site; other site 679896000728 dimerization interface [polypeptide binding]; other site 679896000729 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 679896000730 DNA binding site [nucleotide binding] 679896000731 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 679896000732 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 679896000733 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 679896000734 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 679896000735 DNA binding domain, excisionase family; Region: excise; TIGR01764 679896000736 Thioredoxin; Region: Thioredoxin_4; cl17273 679896000737 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 679896000738 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 679896000739 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 679896000740 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 679896000741 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 679896000742 motif II; other site 679896000743 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 679896000744 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 679896000745 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 679896000746 tRNA; other site 679896000747 putative tRNA binding site [nucleotide binding]; other site 679896000748 putative NADP binding site [chemical binding]; other site 679896000749 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 679896000750 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 679896000751 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 679896000752 domain interfaces; other site 679896000753 active site 679896000754 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 679896000755 active site 679896000756 homodimer interface [polypeptide binding]; other site 679896000757 SAM binding site [chemical binding]; other site 679896000758 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 679896000759 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 679896000760 active site 679896000761 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 679896000762 dimer interface [polypeptide binding]; other site 679896000763 active site 679896000764 Schiff base residues; other site 679896000765 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 679896000766 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 679896000767 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 679896000768 substrate binding site [chemical binding]; other site 679896000769 active site 679896000770 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 679896000771 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 679896000772 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 679896000773 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 679896000774 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 679896000775 inhibitor-cofactor binding pocket; inhibition site 679896000776 pyridoxal 5'-phosphate binding site [chemical binding]; other site 679896000777 catalytic residue [active] 679896000778 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 679896000779 catalytic core [active] 679896000780 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 679896000781 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 679896000782 catalytic residues [active] 679896000783 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 679896000784 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 679896000785 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 679896000786 ResB-like family; Region: ResB; pfam05140 679896000787 Methyltransferase domain; Region: Methyltransf_31; pfam13847 679896000788 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 679896000789 S-adenosylmethionine binding site [chemical binding]; other site 679896000790 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 679896000791 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 679896000792 Walker A/P-loop; other site 679896000793 ATP binding site [chemical binding]; other site 679896000794 Q-loop/lid; other site 679896000795 ABC transporter signature motif; other site 679896000796 Walker B; other site 679896000797 D-loop; other site 679896000798 H-loop/switch region; other site 679896000799 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 679896000800 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 679896000801 intersubunit interface [polypeptide binding]; other site 679896000802 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 679896000803 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 679896000804 ABC-ATPase subunit interface; other site 679896000805 dimer interface [polypeptide binding]; other site 679896000806 putative PBP binding regions; other site 679896000807 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 679896000808 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 679896000809 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 679896000810 UbiA prenyltransferase family; Region: UbiA; pfam01040 679896000811 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 679896000812 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 679896000813 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 679896000814 acyl-activating enzyme (AAE) consensus motif; other site 679896000815 acyl-activating enzyme (AAE) consensus motif; other site 679896000816 AMP binding site [chemical binding]; other site 679896000817 active site 679896000818 CoA binding site [chemical binding]; other site 679896000819 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 679896000820 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 679896000821 substrate binding site [chemical binding]; other site 679896000822 oxyanion hole (OAH) forming residues; other site 679896000823 trimer interface [polypeptide binding]; other site 679896000824 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 679896000825 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 679896000826 O-succinylbenzoate synthase; Provisional; Region: PRK02901 679896000827 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 679896000828 active site 679896000829 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 679896000830 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 679896000831 dimer interface [polypeptide binding]; other site 679896000832 tetramer interface [polypeptide binding]; other site 679896000833 PYR/PP interface [polypeptide binding]; other site 679896000834 TPP binding site [chemical binding]; other site 679896000835 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 679896000836 TPP-binding site; other site 679896000837 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 679896000838 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 679896000839 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 679896000840 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 679896000841 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 679896000842 S-adenosylmethionine binding site [chemical binding]; other site 679896000843 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 679896000844 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 679896000845 NAD(P) binding site [chemical binding]; other site 679896000846 LDH/MDH dimer interface [polypeptide binding]; other site 679896000847 substrate binding site [chemical binding]; other site 679896000848 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 679896000849 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 679896000850 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 679896000851 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 679896000852 substrate binding pocket [chemical binding]; other site 679896000853 chain length determination region; other site 679896000854 substrate-Mg2+ binding site; other site 679896000855 catalytic residues [active] 679896000856 aspartate-rich region 1; other site 679896000857 active site lid residues [active] 679896000858 aspartate-rich region 2; other site 679896000859 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 679896000860 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 679896000861 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 679896000862 putative homodimer interface [polypeptide binding]; other site 679896000863 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 679896000864 heterodimer interface [polypeptide binding]; other site 679896000865 homodimer interface [polypeptide binding]; other site 679896000866 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 679896000867 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 679896000868 23S rRNA interface [nucleotide binding]; other site 679896000869 L7/L12 interface [polypeptide binding]; other site 679896000870 putative thiostrepton binding site; other site 679896000871 L25 interface [polypeptide binding]; other site 679896000872 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 679896000873 mRNA/rRNA interface [nucleotide binding]; other site 679896000874 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 679896000875 trimer interface [polypeptide binding]; other site 679896000876 active site 679896000877 G bulge; other site 679896000878 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 679896000879 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 679896000880 FMN binding site [chemical binding]; other site 679896000881 active site 679896000882 substrate binding site [chemical binding]; other site 679896000883 catalytic residue [active] 679896000884 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 679896000885 23S rRNA interface [nucleotide binding]; other site 679896000886 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 679896000887 50S ribosomal protein L7/L12; Reviewed; Region: rplL; PRK00157 679896000888 L11 interface [polypeptide binding]; other site 679896000889 putative EF-Tu interaction site [polypeptide binding]; other site 679896000890 putative EF-G interaction site [polypeptide binding]; other site 679896000891 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 679896000892 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 679896000893 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 679896000894 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 679896000895 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 679896000896 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 679896000897 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 679896000898 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 679896000899 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 679896000900 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 679896000901 ABC-ATPase subunit interface; other site 679896000902 dimer interface [polypeptide binding]; other site 679896000903 putative PBP binding regions; other site 679896000904 Ethylene insensitive 3; Region: EIN3; cl04813 679896000905 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 679896000906 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 679896000907 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 679896000908 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 679896000909 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 679896000910 RPB1 interaction site [polypeptide binding]; other site 679896000911 RPB10 interaction site [polypeptide binding]; other site 679896000912 RPB11 interaction site [polypeptide binding]; other site 679896000913 RPB3 interaction site [polypeptide binding]; other site 679896000914 RPB12 interaction site [polypeptide binding]; other site 679896000915 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 679896000916 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 679896000917 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 679896000918 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 679896000919 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 679896000920 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 679896000921 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 679896000922 G-loop; other site 679896000923 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 679896000924 DNA binding site [nucleotide binding] 679896000925 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 679896000926 Histidine kinase; Region: HisKA_3; pfam07730 679896000927 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 679896000928 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 679896000929 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 679896000930 active site 679896000931 phosphorylation site [posttranslational modification] 679896000932 intermolecular recognition site; other site 679896000933 dimerization interface [polypeptide binding]; other site 679896000934 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 679896000935 DNA binding residues [nucleotide binding] 679896000936 dimerization interface [polypeptide binding]; other site 679896000937 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 679896000938 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 679896000939 Walker A/P-loop; other site 679896000940 ATP binding site [chemical binding]; other site 679896000941 Q-loop/lid; other site 679896000942 ABC transporter signature motif; other site 679896000943 Walker B; other site 679896000944 D-loop; other site 679896000945 H-loop/switch region; other site 679896000946 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 679896000947 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 679896000948 TIGR03943 family protein; Region: TIGR03943 679896000949 Predicted permease; Region: DUF318; cl17795 679896000950 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 679896000951 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 679896000952 FeS/SAM binding site; other site 679896000953 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 679896000954 Class III ribonucleotide reductase; Region: RNR_III; cd01675 679896000955 effector binding site; other site 679896000956 active site 679896000957 Zn binding site [ion binding]; other site 679896000958 glycine loop; other site 679896000959 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 679896000960 S17 interaction site [polypeptide binding]; other site 679896000961 S8 interaction site; other site 679896000962 16S rRNA interaction site [nucleotide binding]; other site 679896000963 streptomycin interaction site [chemical binding]; other site 679896000964 23S rRNA interaction site [nucleotide binding]; other site 679896000965 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 679896000966 30S ribosomal protein S7; Validated; Region: PRK05302 679896000967 elongation factor G; Reviewed; Region: PRK00007 679896000968 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 679896000969 G1 box; other site 679896000970 putative GEF interaction site [polypeptide binding]; other site 679896000971 GTP/Mg2+ binding site [chemical binding]; other site 679896000972 Switch I region; other site 679896000973 G2 box; other site 679896000974 G3 box; other site 679896000975 Switch II region; other site 679896000976 G4 box; other site 679896000977 G5 box; other site 679896000978 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 679896000979 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 679896000980 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 679896000981 elongation factor Tu; Reviewed; Region: PRK00049 679896000982 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 679896000983 G1 box; other site 679896000984 GEF interaction site [polypeptide binding]; other site 679896000985 GTP/Mg2+ binding site [chemical binding]; other site 679896000986 Switch I region; other site 679896000987 G2 box; other site 679896000988 G3 box; other site 679896000989 Switch II region; other site 679896000990 G4 box; other site 679896000991 G5 box; other site 679896000992 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 679896000993 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 679896000994 Antibiotic Binding Site [chemical binding]; other site 679896000995 Asp23 family; Region: Asp23; cl00574 679896000996 Asp23 family; Region: Asp23; cl00574 679896000997 Asp23 family; Region: Asp23; pfam03780 679896000998 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 679896000999 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 679896001000 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 679896001001 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 679896001002 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 679896001003 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 679896001004 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 679896001005 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 679896001006 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 679896001007 putative translocon binding site; other site 679896001008 protein-rRNA interface [nucleotide binding]; other site 679896001009 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 679896001010 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 679896001011 G-X-X-G motif; other site 679896001012 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 679896001013 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 679896001014 23S rRNA interface [nucleotide binding]; other site 679896001015 5S rRNA interface [nucleotide binding]; other site 679896001016 putative antibiotic binding site [chemical binding]; other site 679896001017 L25 interface [polypeptide binding]; other site 679896001018 L27 interface [polypeptide binding]; other site 679896001019 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 679896001020 putative translocon interaction site; other site 679896001021 23S rRNA interface [nucleotide binding]; other site 679896001022 signal recognition particle (SRP54) interaction site; other site 679896001023 L23 interface [polypeptide binding]; other site 679896001024 trigger factor interaction site; other site 679896001025 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 679896001026 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 679896001027 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 679896001028 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 679896001029 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 679896001030 Walker A/P-loop; other site 679896001031 ATP binding site [chemical binding]; other site 679896001032 Q-loop/lid; other site 679896001033 ABC transporter signature motif; other site 679896001034 Walker B; other site 679896001035 D-loop; other site 679896001036 H-loop/switch region; other site 679896001037 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 679896001038 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 679896001039 Walker A/P-loop; other site 679896001040 ATP binding site [chemical binding]; other site 679896001041 Q-loop/lid; other site 679896001042 ABC transporter signature motif; other site 679896001043 Walker B; other site 679896001044 D-loop; other site 679896001045 H-loop/switch region; other site 679896001046 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 679896001047 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 679896001048 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 679896001049 dimer interface [polypeptide binding]; other site 679896001050 conserved gate region; other site 679896001051 putative PBP binding loops; other site 679896001052 ABC-ATPase subunit interface; other site 679896001053 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 679896001054 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 679896001055 putative PBP binding loops; other site 679896001056 dimer interface [polypeptide binding]; other site 679896001057 ABC-ATPase subunit interface; other site 679896001058 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 679896001059 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 679896001060 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 679896001061 RNA binding site [nucleotide binding]; other site 679896001062 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 679896001063 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 679896001064 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 679896001065 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 679896001066 serine transporter; Region: stp; TIGR00814 679896001067 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 679896001068 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 679896001069 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 679896001070 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 679896001071 active site 679896001072 homotetramer interface [polypeptide binding]; other site 679896001073 homodimer interface [polypeptide binding]; other site 679896001074 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 679896001075 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 679896001076 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 679896001077 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 679896001078 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 679896001079 5S rRNA interface [nucleotide binding]; other site 679896001080 23S rRNA interface [nucleotide binding]; other site 679896001081 L5 interface [polypeptide binding]; other site 679896001082 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 679896001083 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 679896001084 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 679896001085 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 679896001086 23S rRNA binding site [nucleotide binding]; other site 679896001087 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 679896001088 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 679896001089 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 679896001090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 679896001091 dimer interface [polypeptide binding]; other site 679896001092 conserved gate region; other site 679896001093 putative PBP binding loops; other site 679896001094 ABC-ATPase subunit interface; other site 679896001095 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 679896001096 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 679896001097 dimer interface [polypeptide binding]; other site 679896001098 conserved gate region; other site 679896001099 putative PBP binding loops; other site 679896001100 ABC-ATPase subunit interface; other site 679896001101 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 679896001102 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 679896001103 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 679896001104 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 679896001105 Walker A/P-loop; other site 679896001106 ATP binding site [chemical binding]; other site 679896001107 Q-loop/lid; other site 679896001108 ABC transporter signature motif; other site 679896001109 Walker B; other site 679896001110 D-loop; other site 679896001111 H-loop/switch region; other site 679896001112 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 679896001113 SecY translocase; Region: SecY; pfam00344 679896001114 adenylate kinase; Reviewed; Region: adk; PRK00279 679896001115 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 679896001116 AMP-binding site [chemical binding]; other site 679896001117 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 679896001118 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 679896001119 catalytic site [active] 679896001120 BNR repeat-like domain; Region: BNR_2; pfam13088 679896001121 Asp-box motif; other site 679896001122 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 679896001123 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 679896001124 rRNA binding site [nucleotide binding]; other site 679896001125 predicted 30S ribosome binding site; other site 679896001126 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 679896001127 30S ribosomal protein S13; Region: bact_S13; TIGR03631 679896001128 30S ribosomal protein S11; Validated; Region: PRK05309 679896001129 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 679896001130 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 679896001131 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 679896001132 RNA binding surface [nucleotide binding]; other site 679896001133 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 679896001134 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 679896001135 alphaNTD - beta interaction site [polypeptide binding]; other site 679896001136 alphaNTD homodimer interface [polypeptide binding]; other site 679896001137 alphaNTD - beta' interaction site [polypeptide binding]; other site 679896001138 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 679896001139 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 679896001140 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 679896001141 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 679896001142 dimerization interface 3.5A [polypeptide binding]; other site 679896001143 active site 679896001144 Protein of unknown function (DUF690); Region: DUF690; cl04939 679896001145 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 679896001146 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 679896001147 active site 679896001148 catalytic residues [active] 679896001149 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 679896001150 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 679896001151 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 679896001152 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 679896001153 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 679896001154 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 679896001155 Walker A/P-loop; other site 679896001156 ATP binding site [chemical binding]; other site 679896001157 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 679896001158 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 679896001159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 679896001160 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 679896001161 23S rRNA interface [nucleotide binding]; other site 679896001162 L3 interface [polypeptide binding]; other site 679896001163 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 679896001164 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 679896001165 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 679896001166 active site 679896001167 substrate binding site [chemical binding]; other site 679896001168 metal binding site [ion binding]; metal-binding site 679896001169 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 679896001170 alanine racemase; Reviewed; Region: alr; PRK00053 679896001171 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 679896001172 active site 679896001173 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 679896001174 dimer interface [polypeptide binding]; other site 679896001175 substrate binding site [chemical binding]; other site 679896001176 catalytic residues [active] 679896001177 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 679896001178 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 679896001179 Glycoprotease family; Region: Peptidase_M22; pfam00814 679896001180 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 679896001181 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 679896001182 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 679896001183 Coenzyme A binding pocket [chemical binding]; other site 679896001184 UGMP family protein; Validated; Region: PRK09604 679896001185 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 679896001186 oligomerisation interface [polypeptide binding]; other site 679896001187 mobile loop; other site 679896001188 roof hairpin; other site 679896001189 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 679896001190 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 679896001191 ring oligomerisation interface [polypeptide binding]; other site 679896001192 ATP/Mg binding site [chemical binding]; other site 679896001193 stacking interactions; other site 679896001194 hinge regions; other site 679896001195 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 679896001196 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 679896001197 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 679896001198 DNA binding residues [nucleotide binding] 679896001199 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 679896001200 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 679896001201 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 679896001202 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 679896001203 active site 679896001204 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 679896001205 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 679896001206 phosphate binding site [ion binding]; other site 679896001207 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 679896001208 GMP synthase; Reviewed; Region: guaA; PRK00074 679896001209 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 679896001210 AMP/PPi binding site [chemical binding]; other site 679896001211 candidate oxyanion hole; other site 679896001212 catalytic triad [active] 679896001213 potential glutamine specificity residues [chemical binding]; other site 679896001214 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 679896001215 ATP Binding subdomain [chemical binding]; other site 679896001216 Ligand Binding sites [chemical binding]; other site 679896001217 Dimerization subdomain; other site 679896001218 PspC domain; Region: PspC; cl00864 679896001219 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 679896001220 PspC domain; Region: PspC; pfam04024 679896001221 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 679896001222 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 679896001223 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 679896001224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 679896001225 active site 679896001226 phosphorylation site [posttranslational modification] 679896001227 intermolecular recognition site; other site 679896001228 dimerization interface [polypeptide binding]; other site 679896001229 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 679896001230 dimerization interface [polypeptide binding]; other site 679896001231 DNA binding residues [nucleotide binding] 679896001232 AMIN domain; Region: AMIN; pfam11741 679896001233 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 679896001234 putative dimer interface [polypeptide binding]; other site 679896001235 putative [2Fe-2S] cluster binding site [ion binding]; other site 679896001236 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 679896001237 dimer interface [polypeptide binding]; other site 679896001238 conserved gate region; other site 679896001239 ABC-ATPase subunit interface; other site 679896001240 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 679896001241 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 679896001242 Walker A/P-loop; other site 679896001243 ATP binding site [chemical binding]; other site 679896001244 Q-loop/lid; other site 679896001245 ABC transporter signature motif; other site 679896001246 Walker B; other site 679896001247 D-loop; other site 679896001248 H-loop/switch region; other site 679896001249 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 679896001250 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 679896001251 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 679896001252 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 679896001253 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 679896001254 intersubunit interface [polypeptide binding]; other site 679896001255 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 679896001256 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 679896001257 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 679896001258 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 679896001259 ABC-ATPase subunit interface; other site 679896001260 dimer interface [polypeptide binding]; other site 679896001261 putative PBP binding regions; other site 679896001262 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 679896001263 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 679896001264 ABC-ATPase subunit interface; other site 679896001265 dimer interface [polypeptide binding]; other site 679896001266 putative PBP binding regions; other site 679896001267 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 679896001268 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 679896001269 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 679896001270 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 679896001271 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 679896001272 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 679896001273 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 679896001274 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 679896001275 homodimer interface [polypeptide binding]; other site 679896001276 NADP binding site [chemical binding]; other site 679896001277 substrate binding site [chemical binding]; other site 679896001278 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 679896001279 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 679896001280 active site 679896001281 Htaa; Region: HtaA; pfam04213 679896001282 Htaa; Region: HtaA; pfam04213 679896001283 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 679896001284 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 679896001285 intersubunit interface [polypeptide binding]; other site 679896001286 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 679896001287 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 679896001288 ABC-ATPase subunit interface; other site 679896001289 dimer interface [polypeptide binding]; other site 679896001290 putative PBP binding regions; other site 679896001291 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 679896001292 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 679896001293 Walker A/P-loop; other site 679896001294 ATP binding site [chemical binding]; other site 679896001295 Q-loop/lid; other site 679896001296 ABC transporter signature motif; other site 679896001297 Walker B; other site 679896001298 D-loop; other site 679896001299 H-loop/switch region; other site 679896001300 Htaa; Region: HtaA; pfam04213 679896001301 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 679896001302 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 679896001303 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 679896001304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 679896001305 putative substrate translocation pore; other site 679896001306 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 679896001307 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 679896001308 DNA binding residues [nucleotide binding] 679896001309 dimer interface [polypeptide binding]; other site 679896001310 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 679896001311 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 679896001312 putative catalytic site [active] 679896001313 putative metal binding site [ion binding]; other site 679896001314 putative phosphate binding site [ion binding]; other site 679896001315 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 679896001316 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 679896001317 active site 679896001318 HIGH motif; other site 679896001319 dimer interface [polypeptide binding]; other site 679896001320 KMSKS motif; other site 679896001321 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 679896001322 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 679896001323 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 679896001324 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 679896001325 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 679896001326 active site 679896001327 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 679896001328 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 679896001329 non-specific DNA binding site [nucleotide binding]; other site 679896001330 salt bridge; other site 679896001331 sequence-specific DNA binding site [nucleotide binding]; other site 679896001332 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 679896001333 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 679896001334 active site 679896001335 substrate binding site [chemical binding]; other site 679896001336 metal binding site [ion binding]; metal-binding site 679896001337 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 679896001338 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 679896001339 metal binding site [ion binding]; metal-binding site 679896001340 putative dimer interface [polypeptide binding]; other site 679896001341 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 679896001342 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 679896001343 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 679896001344 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 679896001345 pyruvate carboxylase; Reviewed; Region: PRK12999 679896001346 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 679896001347 ATP-grasp domain; Region: ATP-grasp_4; cl17255 679896001348 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 679896001349 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 679896001350 active site 679896001351 catalytic residues [active] 679896001352 metal binding site [ion binding]; metal-binding site 679896001353 homodimer binding site [polypeptide binding]; other site 679896001354 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 679896001355 carboxyltransferase (CT) interaction site; other site 679896001356 biotinylation site [posttranslational modification]; other site 679896001357 Major Facilitator Superfamily; Region: MFS_1; pfam07690 679896001358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 679896001359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 679896001360 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 679896001361 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 679896001362 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 679896001363 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 679896001364 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 679896001365 carboxyltransferase (CT) interaction site; other site 679896001366 biotinylation site [posttranslational modification]; other site 679896001367 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 679896001368 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 679896001369 active site residue [active] 679896001370 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 679896001371 active site residue [active] 679896001372 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 679896001373 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 679896001374 Maf-like protein; Region: Maf; pfam02545 679896001375 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 679896001376 active site 679896001377 dimer interface [polypeptide binding]; other site 679896001378 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 679896001379 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 679896001380 substrate binding site [chemical binding]; other site 679896001381 ATP binding site [chemical binding]; other site 679896001382 Transcriptional regulators [Transcription]; Region: PurR; COG1609 679896001383 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 679896001384 DNA binding site [nucleotide binding] 679896001385 domain linker motif; other site 679896001386 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 679896001387 putative ligand binding site [chemical binding]; other site 679896001388 dimerization interface [polypeptide binding]; other site 679896001389 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 679896001390 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 679896001391 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 679896001392 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 679896001393 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 679896001394 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 679896001395 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 679896001396 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 679896001397 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 679896001398 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 679896001399 ATP-grasp domain; Region: ATP-grasp; pfam02222 679896001400 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 679896001401 Uncharacterized conserved protein [Function unknown]; Region: COG1434 679896001402 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 679896001403 putative active site [active] 679896001404 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 679896001405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 679896001406 dimer interface [polypeptide binding]; other site 679896001407 conserved gate region; other site 679896001408 putative PBP binding loops; other site 679896001409 ABC-ATPase subunit interface; other site 679896001410 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 679896001411 dimer interface [polypeptide binding]; other site 679896001412 conserved gate region; other site 679896001413 putative PBP binding loops; other site 679896001414 ABC-ATPase subunit interface; other site 679896001415 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 679896001416 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 679896001417 TIGR03089 family protein; Region: TIGR03089 679896001418 Transcriptional regulator [Transcription]; Region: LytR; COG1316 679896001419 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 679896001420 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 679896001421 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 679896001422 Probable Catalytic site; other site 679896001423 metal-binding site 679896001424 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 679896001425 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 679896001426 active site 679896001427 Substrate binding site; other site 679896001428 Mg++ binding site; other site 679896001429 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 679896001430 putative trimer interface [polypeptide binding]; other site 679896001431 putative CoA binding site [chemical binding]; other site 679896001432 Transcription factor WhiB; Region: Whib; pfam02467 679896001433 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 679896001434 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 679896001435 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 679896001436 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 679896001437 active site 679896001438 substrate binding site [chemical binding]; other site 679896001439 metal binding site [ion binding]; metal-binding site 679896001440 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 679896001441 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 679896001442 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 679896001443 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 679896001444 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 679896001445 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 679896001446 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 679896001447 homotetramer interface [polypeptide binding]; other site 679896001448 ligand binding site [chemical binding]; other site 679896001449 catalytic site [active] 679896001450 NAD binding site [chemical binding]; other site 679896001451 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 679896001452 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 679896001453 TMP-binding site; other site 679896001454 ATP-binding site [chemical binding]; other site 679896001455 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 679896001456 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 679896001457 active site 679896001458 phosphorylation site [posttranslational modification] 679896001459 intermolecular recognition site; other site 679896001460 dimerization interface [polypeptide binding]; other site 679896001461 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 679896001462 DNA binding site [nucleotide binding] 679896001463 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 679896001464 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 679896001465 dimerization interface [polypeptide binding]; other site 679896001466 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 679896001467 dimer interface [polypeptide binding]; other site 679896001468 phosphorylation site [posttranslational modification] 679896001469 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 679896001470 ATP binding site [chemical binding]; other site 679896001471 Mg2+ binding site [ion binding]; other site 679896001472 G-X-G motif; other site 679896001473 lipoprotein LpqB; Provisional; Region: PRK13616 679896001474 Sporulation and spore germination; Region: Germane; pfam10646 679896001475 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 679896001476 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 679896001477 active site 679896001478 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 679896001479 30S subunit binding site; other site 679896001480 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 679896001481 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 679896001482 ATP binding site [chemical binding]; other site 679896001483 putative Mg++ binding site [ion binding]; other site 679896001484 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 679896001485 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 679896001486 nucleotide binding region [chemical binding]; other site 679896001487 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 679896001488 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 679896001489 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 679896001490 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 679896001491 FAD binding pocket [chemical binding]; other site 679896001492 FAD binding motif [chemical binding]; other site 679896001493 phosphate binding motif [ion binding]; other site 679896001494 beta-alpha-beta structure motif; other site 679896001495 NAD binding pocket [chemical binding]; other site 679896001496 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 679896001497 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 679896001498 catalytic loop [active] 679896001499 iron binding site [ion binding]; other site 679896001500 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 679896001501 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 679896001502 putative di-iron ligands [ion binding]; other site 679896001503 Predicted GTPases [General function prediction only]; Region: COG1162 679896001504 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 679896001505 GTPase/Zn-binding domain interface [polypeptide binding]; other site 679896001506 GTP/Mg2+ binding site [chemical binding]; other site 679896001507 G4 box; other site 679896001508 G5 box; other site 679896001509 G1 box; other site 679896001510 Switch I region; other site 679896001511 G2 box; other site 679896001512 G3 box; other site 679896001513 Switch II region; other site 679896001514 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 679896001515 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 679896001516 hinge; other site 679896001517 active site 679896001518 Uncharacterized conserved protein [Function unknown]; Region: COG2135 679896001519 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 679896001520 putative deacylase active site [active] 679896001521 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 679896001522 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 679896001523 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 679896001524 DNA binding residues [nucleotide binding] 679896001525 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 679896001526 Transcription factor WhiB; Region: Whib; pfam02467 679896001527 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 679896001528 active site 679896001529 catalytic triad [active] 679896001530 oxyanion hole [active] 679896001531 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 679896001532 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 679896001533 DEAD-like helicases superfamily; Region: DEXDc; smart00487 679896001534 ATP binding site [chemical binding]; other site 679896001535 Mg++ binding site [ion binding]; other site 679896001536 motif III; other site 679896001537 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 679896001538 nucleotide binding region [chemical binding]; other site 679896001539 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 679896001540 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 679896001541 TIGR02569 family protein; Region: TIGR02569_actnb 679896001542 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 679896001543 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 679896001544 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 679896001545 Part of AAA domain; Region: AAA_19; pfam13245 679896001546 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 679896001547 Ion channel; Region: Ion_trans_2; pfam07885 679896001548 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 679896001549 TrkA-N domain; Region: TrkA_N; pfam02254 679896001550 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 679896001551 putative NADH binding site [chemical binding]; other site 679896001552 putative active site [active] 679896001553 nudix motif; other site 679896001554 putative metal binding site [ion binding]; other site 679896001555 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 679896001556 Part of AAA domain; Region: AAA_19; pfam13245 679896001557 Family description; Region: UvrD_C_2; pfam13538 679896001558 HRDC domain; Region: HRDC; pfam00570 679896001559 Protein of unknown function DUF45; Region: DUF45; cl00636 679896001560 putative hydrolase; Region: TIGR03624 679896001561 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 679896001562 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 679896001563 hypothetical protein; Validated; Region: PRK00068 679896001564 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 679896001565 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 679896001566 sequence-specific DNA binding site [nucleotide binding]; other site 679896001567 salt bridge; other site 679896001568 Abi-like protein; Region: Abi_2; pfam07751 679896001569 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 679896001570 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 679896001571 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 679896001572 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 679896001573 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 679896001574 Predicted membrane protein [Function unknown]; Region: COG2311 679896001575 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 679896001576 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 679896001577 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 679896001578 acyl-activating enzyme (AAE) consensus motif; other site 679896001579 AMP binding site [chemical binding]; other site 679896001580 active site 679896001581 CoA binding site [chemical binding]; other site 679896001582 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 679896001583 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 679896001584 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 679896001585 putative trimer interface [polypeptide binding]; other site 679896001586 putative CoA binding site [chemical binding]; other site 679896001587 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 679896001588 putative trimer interface [polypeptide binding]; other site 679896001589 putative CoA binding site [chemical binding]; other site 679896001590 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 679896001591 oxaloacetate decarboxylase; Provisional; Region: PRK12330 679896001592 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 679896001593 active site 679896001594 catalytic residues [active] 679896001595 metal binding site [ion binding]; metal-binding site 679896001596 homodimer binding site [polypeptide binding]; other site 679896001597 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 679896001598 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 679896001599 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 679896001600 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 679896001601 carboxyltransferase (CT) interaction site; other site 679896001602 biotinylation site [posttranslational modification]; other site 679896001603 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 679896001604 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 679896001605 active site 679896001606 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 679896001607 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 679896001608 active site 679896001609 peptide chain release factor 2; Validated; Region: prfB; PRK00578 679896001610 This domain is found in peptide chain release factors; Region: PCRF; smart00937 679896001611 RF-1 domain; Region: RF-1; pfam00472 679896001612 topology modulation protein; Provisional; Region: PRK07261 679896001613 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 679896001614 active site 679896001615 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 679896001616 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 679896001617 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 679896001618 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 679896001619 Walker A/P-loop; other site 679896001620 ATP binding site [chemical binding]; other site 679896001621 Q-loop/lid; other site 679896001622 ABC transporter signature motif; other site 679896001623 Walker B; other site 679896001624 D-loop; other site 679896001625 H-loop/switch region; other site 679896001626 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 679896001627 FtsX-like permease family; Region: FtsX; pfam02687 679896001628 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 679896001629 SmpB-tmRNA interface; other site 679896001630 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 679896001631 active site clefts [active] 679896001632 zinc binding site [ion binding]; other site 679896001633 dimer interface [polypeptide binding]; other site 679896001634 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 679896001635 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 679896001636 intersubunit interface [polypeptide binding]; other site 679896001637 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 679896001638 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 679896001639 ABC-ATPase subunit interface; other site 679896001640 dimer interface [polypeptide binding]; other site 679896001641 putative PBP binding regions; other site 679896001642 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 679896001643 ABC-ATPase subunit interface; other site 679896001644 dimer interface [polypeptide binding]; other site 679896001645 putative PBP binding regions; other site 679896001646 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 679896001647 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 679896001648 Walker A/P-loop; other site 679896001649 ATP binding site [chemical binding]; other site 679896001650 Q-loop/lid; other site 679896001651 ABC transporter signature motif; other site 679896001652 Walker B; other site 679896001653 D-loop; other site 679896001654 H-loop/switch region; other site 679896001655 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 679896001656 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 679896001657 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 679896001658 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 679896001659 ATP binding site [chemical binding]; other site 679896001660 putative Mg++ binding site [ion binding]; other site 679896001661 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 679896001662 nucleotide binding region [chemical binding]; other site 679896001663 ATP-binding site [chemical binding]; other site 679896001664 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 679896001665 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 679896001666 Protein of unknown function (DUF3235); Region: DUF3235; pfam11574 679896001667 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 679896001668 DNA-binding site [nucleotide binding]; DNA binding site 679896001669 RNA-binding motif; other site 679896001670 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 679896001671 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 679896001672 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 679896001673 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 679896001674 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 679896001675 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 679896001676 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 679896001677 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 679896001678 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 679896001679 catalytic residue [active] 679896001680 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 679896001681 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 679896001682 dimer interface [polypeptide binding]; other site 679896001683 active site 679896001684 citrylCoA binding site [chemical binding]; other site 679896001685 NADH binding [chemical binding]; other site 679896001686 cationic pore residues; other site 679896001687 oxalacetate/citrate binding site [chemical binding]; other site 679896001688 coenzyme A binding site [chemical binding]; other site 679896001689 catalytic triad [active] 679896001690 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 679896001691 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 679896001692 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 679896001693 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 679896001694 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 679896001695 E-class dimer interface [polypeptide binding]; other site 679896001696 P-class dimer interface [polypeptide binding]; other site 679896001697 active site 679896001698 Cu2+ binding site [ion binding]; other site 679896001699 Zn2+ binding site [ion binding]; other site 679896001700 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 679896001701 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 679896001702 active site 679896001703 catalytic tetrad [active] 679896001704 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 679896001705 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 679896001706 substrate binding site [chemical binding]; other site 679896001707 oxyanion hole (OAH) forming residues; other site 679896001708 trimer interface [polypeptide binding]; other site 679896001709 Protein of unknown function, DUF485; Region: DUF485; pfam04341 679896001710 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 679896001711 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 679896001712 Na binding site [ion binding]; other site 679896001713 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 679896001714 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 679896001715 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 679896001716 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 679896001717 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 679896001718 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 679896001719 multidrug efflux protein NorA; Provisional; Region: PRK00187 679896001720 cation binding site [ion binding]; other site 679896001721 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 679896001722 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 679896001723 dimer interface [polypeptide binding]; other site 679896001724 pyridoxal 5'-phosphate binding site [chemical binding]; other site 679896001725 catalytic residue [active] 679896001726 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 679896001727 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 679896001728 catalytic residue [active] 679896001729 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 679896001730 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 679896001731 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 679896001732 substrate binding pocket [chemical binding]; other site 679896001733 active site 679896001734 iron coordination sites [ion binding]; other site 679896001735 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 679896001736 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 679896001737 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 679896001738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 679896001739 dimer interface [polypeptide binding]; other site 679896001740 conserved gate region; other site 679896001741 putative PBP binding loops; other site 679896001742 ABC-ATPase subunit interface; other site 679896001743 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 679896001744 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 679896001745 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 679896001746 Walker A/P-loop; other site 679896001747 ATP binding site [chemical binding]; other site 679896001748 Q-loop/lid; other site 679896001749 ABC transporter signature motif; other site 679896001750 Walker B; other site 679896001751 D-loop; other site 679896001752 H-loop/switch region; other site 679896001753 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 679896001754 Walker A/P-loop; other site 679896001755 ATP binding site [chemical binding]; other site 679896001756 Q-loop/lid; other site 679896001757 ABC transporter signature motif; other site 679896001758 Walker B; other site 679896001759 D-loop; other site 679896001760 H-loop/switch region; other site 679896001761 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 679896001762 active site 679896001763 SAM binding site [chemical binding]; other site 679896001764 homodimer interface [polypeptide binding]; other site 679896001765 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 679896001766 catalytic residues [active] 679896001767 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 679896001768 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 679896001769 folate binding site [chemical binding]; other site 679896001770 NADP+ binding site [chemical binding]; other site 679896001771 thymidylate synthase; Reviewed; Region: thyA; PRK01827 679896001772 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 679896001773 dimerization interface [polypeptide binding]; other site 679896001774 active site 679896001775 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 679896001776 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 679896001777 active site 679896001778 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 679896001779 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 679896001780 ATP binding site [chemical binding]; other site 679896001781 putative Mg++ binding site [ion binding]; other site 679896001782 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 679896001783 nucleotide binding region [chemical binding]; other site 679896001784 ATP-binding site [chemical binding]; other site 679896001785 DEAD/H associated; Region: DEAD_assoc; pfam08494 679896001786 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 679896001787 active site 679896001788 SUMO-1 interface [polypeptide binding]; other site 679896001789 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 679896001790 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 679896001791 putative DNA binding site [nucleotide binding]; other site 679896001792 catalytic residue [active] 679896001793 putative H2TH interface [polypeptide binding]; other site 679896001794 putative catalytic residues [active] 679896001795 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 679896001796 hypothetical protein; Provisional; Region: PRK11770 679896001797 Domain of unknown function (DUF307); Region: DUF307; pfam03733 679896001798 Domain of unknown function (DUF307); Region: DUF307; pfam03733 679896001799 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 679896001800 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 679896001801 active site 679896001802 dimer interface [polypeptide binding]; other site 679896001803 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 679896001804 dimer interface [polypeptide binding]; other site 679896001805 active site 679896001806 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 679896001807 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 679896001808 tetramerization interface [polypeptide binding]; other site 679896001809 NAD(P) binding site [chemical binding]; other site 679896001810 catalytic residues [active] 679896001811 hypothetical protein; Provisional; Region: PRK07857 679896001812 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 679896001813 Part of AAA domain; Region: AAA_19; pfam13245 679896001814 Family description; Region: UvrD_C_2; pfam13538 679896001815 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 679896001816 Peptidase family M23; Region: Peptidase_M23; pfam01551 679896001817 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 679896001818 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 679896001819 active site 679896001820 substrate binding site [chemical binding]; other site 679896001821 cosubstrate binding site; other site 679896001822 catalytic site [active] 679896001823 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 679896001824 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 679896001825 purine monophosphate binding site [chemical binding]; other site 679896001826 dimer interface [polypeptide binding]; other site 679896001827 putative catalytic residues [active] 679896001828 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 679896001829 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 679896001830 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 679896001831 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 679896001832 Walker A/P-loop; other site 679896001833 ATP binding site [chemical binding]; other site 679896001834 Q-loop/lid; other site 679896001835 ABC transporter signature motif; other site 679896001836 Walker B; other site 679896001837 D-loop; other site 679896001838 H-loop/switch region; other site 679896001839 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 679896001840 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 679896001841 substrate binding pocket [chemical binding]; other site 679896001842 membrane-bound complex binding site; other site 679896001843 hinge residues; other site 679896001844 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 679896001845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 679896001846 dimer interface [polypeptide binding]; other site 679896001847 conserved gate region; other site 679896001848 putative PBP binding loops; other site 679896001849 ABC-ATPase subunit interface; other site 679896001850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 679896001851 dimer interface [polypeptide binding]; other site 679896001852 conserved gate region; other site 679896001853 putative PBP binding loops; other site 679896001854 ABC-ATPase subunit interface; other site 679896001855 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 679896001856 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 679896001857 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 679896001858 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 679896001859 30S ribosomal protein S18; Provisional; Region: PRK13401 679896001860 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 679896001861 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 679896001862 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 679896001863 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 679896001864 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 679896001865 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 679896001866 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 679896001867 active site 679896001868 phosphorylation site [posttranslational modification] 679896001869 intermolecular recognition site; other site 679896001870 dimerization interface [polypeptide binding]; other site 679896001871 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 679896001872 DNA binding site [nucleotide binding] 679896001873 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 679896001874 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 679896001875 dimerization interface [polypeptide binding]; other site 679896001876 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 679896001877 dimer interface [polypeptide binding]; other site 679896001878 phosphorylation site [posttranslational modification] 679896001879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 679896001880 ATP binding site [chemical binding]; other site 679896001881 Mg2+ binding site [ion binding]; other site 679896001882 G-X-G motif; other site 679896001883 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 679896001884 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 679896001885 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 679896001886 protein binding site [polypeptide binding]; other site 679896001887 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 679896001888 MPT binding site; other site 679896001889 trimer interface [polypeptide binding]; other site 679896001890 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 679896001891 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 679896001892 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 679896001893 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 679896001894 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 679896001895 active site 679896001896 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 679896001897 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 679896001898 dimer interface [polypeptide binding]; other site 679896001899 putative functional site; other site 679896001900 putative MPT binding site; other site 679896001901 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 679896001902 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 679896001903 Coenzyme A binding pocket [chemical binding]; other site 679896001904 Predicted membrane protein [Function unknown]; Region: COG2259 679896001905 Predicted integral membrane protein [Function unknown]; Region: COG5660 679896001906 Putative zinc-finger; Region: zf-HC2; pfam13490 679896001907 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 679896001908 BCCT family transporter; Region: BCCT; pfam02028 679896001909 Uncharacterized membrane protein [Function unknown]; Region: COG3949 679896001910 Predicted methyltransferases [General function prediction only]; Region: COG0313 679896001911 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 679896001912 putative SAM binding site [chemical binding]; other site 679896001913 putative homodimer interface [polypeptide binding]; other site 679896001914 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 679896001915 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 679896001916 active site 679896001917 HIGH motif; other site 679896001918 KMSKS motif; other site 679896001919 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 679896001920 tRNA binding surface [nucleotide binding]; other site 679896001921 anticodon binding site; other site 679896001922 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 679896001923 active site 679896001924 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 679896001925 Domain of unknown function (DUF348); Region: DUF348; pfam03990 679896001926 Domain of unknown function (DUF348); Region: DUF348; pfam03990 679896001927 G5 domain; Region: G5; pfam07501 679896001928 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 679896001929 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 679896001930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 679896001931 S-adenosylmethionine binding site [chemical binding]; other site 679896001932 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 679896001933 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 679896001934 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 679896001935 ABC transporter; Region: ABC_tran_2; pfam12848 679896001936 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 679896001937 Uncharacterized conserved protein [Function unknown]; Region: COG1359 679896001938 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 679896001939 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 679896001940 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 679896001941 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 679896001942 substrate binding site [chemical binding]; other site 679896001943 oxyanion hole (OAH) forming residues; other site 679896001944 trimer interface [polypeptide binding]; other site 679896001945 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 679896001946 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 679896001947 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 679896001948 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 679896001949 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 679896001950 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 679896001951 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 679896001952 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 679896001953 G1 box; other site 679896001954 putative GEF interaction site [polypeptide binding]; other site 679896001955 GTP/Mg2+ binding site [chemical binding]; other site 679896001956 Switch I region; other site 679896001957 G2 box; other site 679896001958 G3 box; other site 679896001959 Switch II region; other site 679896001960 G4 box; other site 679896001961 G5 box; other site 679896001962 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 679896001963 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 679896001964 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 679896001965 NAD(P) binding site [chemical binding]; other site 679896001966 active site 679896001967 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 679896001968 putative active site [active] 679896001969 catalytic residue [active] 679896001970 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 679896001971 FMN binding site [chemical binding]; other site 679896001972 substrate binding site [chemical binding]; other site 679896001973 putative catalytic residue [active] 679896001974 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 679896001975 putative active site [active] 679896001976 catalytic residue [active] 679896001977 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 679896001978 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 679896001979 5S rRNA interface [nucleotide binding]; other site 679896001980 CTC domain interface [polypeptide binding]; other site 679896001981 L16 interface [polypeptide binding]; other site 679896001982 pullulanase, type I; Region: pulA_typeI; TIGR02104 679896001983 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 679896001984 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 679896001985 Ca binding site [ion binding]; other site 679896001986 active site 679896001987 catalytic site [active] 679896001988 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 679896001989 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 679896001990 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 679896001991 active site 679896001992 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 679896001993 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 679896001994 Substrate binding site; other site 679896001995 Mg++ binding site; other site 679896001996 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 679896001997 active site 679896001998 substrate binding site [chemical binding]; other site 679896001999 CoA binding site [chemical binding]; other site 679896002000 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 679896002001 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 679896002002 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 679896002003 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 679896002004 gating phenylalanine in ion channel; other site 679896002005 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 679896002006 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 679896002007 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 679896002008 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 679896002009 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 679896002010 ATP binding site [chemical binding]; other site 679896002011 putative Mg++ binding site [ion binding]; other site 679896002012 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 679896002013 nucleotide binding region [chemical binding]; other site 679896002014 ATP-binding site [chemical binding]; other site 679896002015 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 679896002016 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 679896002017 Spore germination protein; Region: Spore_permease; cl17796 679896002018 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 679896002019 homodimer interface [polypeptide binding]; other site 679896002020 metal binding site [ion binding]; metal-binding site 679896002021 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 679896002022 N-acetyl-D-glucosamine binding site [chemical binding]; other site 679896002023 enolase; Provisional; Region: eno; PRK00077 679896002024 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 679896002025 dimer interface [polypeptide binding]; other site 679896002026 metal binding site [ion binding]; metal-binding site 679896002027 substrate binding pocket [chemical binding]; other site 679896002028 Septum formation initiator; Region: DivIC; pfam04977 679896002029 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 679896002030 Uncharacterized conserved protein [Function unknown]; Region: COG1507 679896002031 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 679896002032 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 679896002033 Helix-turn-helix domain; Region: HTH_18; pfam12833 679896002034 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 679896002035 Bax inhibitor 1 like; Region: BaxI_1; cl17691 679896002036 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 679896002037 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 679896002038 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 679896002039 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 679896002040 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 679896002041 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 679896002042 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 679896002043 catalytic residue [active] 679896002044 putative FPP diphosphate binding site; other site 679896002045 putative FPP binding hydrophobic cleft; other site 679896002046 dimer interface [polypeptide binding]; other site 679896002047 putative IPP diphosphate binding site; other site 679896002048 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 679896002049 pantothenate kinase; Provisional; Region: PRK05439 679896002050 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 679896002051 ATP-binding site [chemical binding]; other site 679896002052 CoA-binding site [chemical binding]; other site 679896002053 Mg2+-binding site [ion binding]; other site 679896002054 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 679896002055 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 679896002056 dimer interface [polypeptide binding]; other site 679896002057 active site 679896002058 glycine-pyridoxal phosphate binding site [chemical binding]; other site 679896002059 folate binding site [chemical binding]; other site 679896002060 Major Facilitator Superfamily; Region: MFS_1; pfam07690 679896002061 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 679896002062 putative substrate translocation pore; other site 679896002063 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 679896002064 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 679896002065 Transcriptional regulator [Transcription]; Region: LysR; COG0583 679896002066 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 679896002067 dimerization interface [polypeptide binding]; other site 679896002068 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 679896002069 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 679896002070 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 679896002071 Coenzyme A binding pocket [chemical binding]; other site 679896002072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 679896002073 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 679896002074 putative substrate translocation pore; other site 679896002075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 679896002076 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 679896002077 fumarate hydratase; Reviewed; Region: fumC; PRK00485 679896002078 Class II fumarases; Region: Fumarase_classII; cd01362 679896002079 active site 679896002080 tetramer interface [polypeptide binding]; other site 679896002081 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 679896002082 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 679896002083 putative active site [active] 679896002084 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 679896002085 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 679896002086 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 679896002087 generic binding surface II; other site 679896002088 generic binding surface I; other site 679896002089 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 679896002090 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 679896002091 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 679896002092 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 679896002093 Domain of unknown function DUF20; Region: UPF0118; pfam01594 679896002094 GTP-binding protein YchF; Reviewed; Region: PRK09601 679896002095 YchF GTPase; Region: YchF; cd01900 679896002096 G1 box; other site 679896002097 GTP/Mg2+ binding site [chemical binding]; other site 679896002098 Switch I region; other site 679896002099 G2 box; other site 679896002100 Switch II region; other site 679896002101 G3 box; other site 679896002102 G4 box; other site 679896002103 G5 box; other site 679896002104 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 679896002105 Protein of unknown function, DUF488; Region: DUF488; pfam04343 679896002106 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 679896002107 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 679896002108 PhnA protein; Region: PhnA; pfam03831 679896002109 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 679896002110 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 679896002111 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 679896002112 Walker A/P-loop; other site 679896002113 ATP binding site [chemical binding]; other site 679896002114 Q-loop/lid; other site 679896002115 ABC transporter signature motif; other site 679896002116 Walker B; other site 679896002117 D-loop; other site 679896002118 H-loop/switch region; other site 679896002119 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 679896002120 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 679896002121 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 679896002122 Walker A/P-loop; other site 679896002123 ATP binding site [chemical binding]; other site 679896002124 Q-loop/lid; other site 679896002125 ABC transporter signature motif; other site 679896002126 Walker B; other site 679896002127 D-loop; other site 679896002128 H-loop/switch region; other site 679896002129 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 679896002130 Walker A/P-loop; other site 679896002131 ATP binding site [chemical binding]; other site 679896002132 Q-loop/lid; other site 679896002133 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 679896002134 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 679896002135 Walker A/P-loop; other site 679896002136 ATP binding site [chemical binding]; other site 679896002137 Q-loop/lid; other site 679896002138 ABC transporter; Region: ABC_tran; pfam00005 679896002139 ABC transporter signature motif; other site 679896002140 Walker B; other site 679896002141 D-loop; other site 679896002142 H-loop/switch region; other site 679896002143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 679896002144 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 679896002145 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 679896002146 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 679896002147 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 679896002148 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 679896002149 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 679896002150 Walker A/P-loop; other site 679896002151 ATP binding site [chemical binding]; other site 679896002152 Q-loop/lid; other site 679896002153 ABC transporter signature motif; other site 679896002154 Walker B; other site 679896002155 D-loop; other site 679896002156 H-loop/switch region; other site 679896002157 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 679896002158 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 679896002159 Walker A/P-loop; other site 679896002160 ATP binding site [chemical binding]; other site 679896002161 Q-loop/lid; other site 679896002162 ABC transporter signature motif; other site 679896002163 Walker B; other site 679896002164 D-loop; other site 679896002165 H-loop/switch region; other site 679896002166 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 679896002167 hypothetical protein; Provisional; Region: PRK06547 679896002168 Predicted kinase [General function prediction only]; Region: COG0645 679896002169 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 679896002170 nudix motif; other site 679896002171 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 679896002172 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 679896002173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 679896002174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 679896002175 dimer interface [polypeptide binding]; other site 679896002176 conserved gate region; other site 679896002177 putative PBP binding loops; other site 679896002178 ABC-ATPase subunit interface; other site 679896002179 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 679896002180 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 679896002181 Walker A/P-loop; other site 679896002182 ATP binding site [chemical binding]; other site 679896002183 Q-loop/lid; other site 679896002184 ABC transporter signature motif; other site 679896002185 Walker B; other site 679896002186 D-loop; other site 679896002187 H-loop/switch region; other site 679896002188 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 679896002189 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 679896002190 Walker A/P-loop; other site 679896002191 ATP binding site [chemical binding]; other site 679896002192 Q-loop/lid; other site 679896002193 ABC transporter signature motif; other site 679896002194 Walker B; other site 679896002195 D-loop; other site 679896002196 H-loop/switch region; other site 679896002197 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 679896002198 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 679896002199 cleavage site 679896002200 active site 679896002201 substrate binding sites [chemical binding]; other site 679896002202 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 679896002203 ArsC family; Region: ArsC; pfam03960 679896002204 catalytic residues [active] 679896002205 Protein of unknown function (DUF402); Region: DUF402; cl00979 679896002206 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 679896002207 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 679896002208 G1 box; other site 679896002209 GTP/Mg2+ binding site [chemical binding]; other site 679896002210 G2 box; other site 679896002211 Switch I region; other site 679896002212 G3 box; other site 679896002213 Switch II region; other site 679896002214 G4 box; other site 679896002215 G5 box; other site 679896002216 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 679896002217 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 679896002218 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 679896002219 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 679896002220 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 679896002221 Ferredoxin [Energy production and conversion]; Region: COG1146 679896002222 4Fe-4S binding domain; Region: Fer4; pfam00037 679896002223 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 679896002224 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 679896002225 pyridoxal 5'-phosphate binding site [chemical binding]; other site 679896002226 homodimer interface [polypeptide binding]; other site 679896002227 catalytic residue [active] 679896002228 Predicted membrane protein [Function unknown]; Region: COG2246 679896002229 GtrA-like protein; Region: GtrA; pfam04138 679896002230 Domain of unknown function (DUF222); Region: DUF222; pfam02720 679896002231 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 679896002232 active site 679896002233 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 679896002234 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 679896002235 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 679896002236 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 679896002237 putative trimer interface [polypeptide binding]; other site 679896002238 putative CoA binding site [chemical binding]; other site 679896002239 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 679896002240 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 679896002241 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 679896002242 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 679896002243 putative trimer interface [polypeptide binding]; other site 679896002244 putative CoA binding site [chemical binding]; other site 679896002245 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 679896002246 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 679896002247 metal binding site [ion binding]; metal-binding site 679896002248 putative dimer interface [polypeptide binding]; other site 679896002249 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 679896002250 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 679896002251 dihydropteroate synthase; Region: DHPS; TIGR01496 679896002252 substrate binding pocket [chemical binding]; other site 679896002253 dimer interface [polypeptide binding]; other site 679896002254 inhibitor binding site; inhibition site 679896002255 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 679896002256 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 679896002257 Ligand binding site; other site 679896002258 Putative Catalytic site; other site 679896002259 DXD motif; other site 679896002260 DivIVA domain; Region: DivI1A_domain; TIGR03544 679896002261 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 679896002262 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 679896002263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 679896002264 S-adenosylmethionine binding site [chemical binding]; other site 679896002265 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 679896002266 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 679896002267 active site 679896002268 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 679896002269 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 679896002270 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 679896002271 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 679896002272 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 679896002273 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 679896002274 ligand binding site; other site 679896002275 oligomer interface; other site 679896002276 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 679896002277 dimer interface [polypeptide binding]; other site 679896002278 N-terminal domain interface [polypeptide binding]; other site 679896002279 sulfate 1 binding site; other site 679896002280 Methyltransferase domain; Region: Methyltransf_24; pfam13578 679896002281 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 679896002282 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 679896002283 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 679896002284 DNA binding residues [nucleotide binding] 679896002285 sec-independent translocase; Provisional; Region: tatB; PRK00182 679896002286 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 679896002287 Domain of unknown function DUF59; Region: DUF59; pfam01883 679896002288 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 679896002289 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 679896002290 Predicted membrane protein [Function unknown]; Region: COG4420 679896002291 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 679896002292 MgtE intracellular N domain; Region: MgtE_N; smart00924 679896002293 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 679896002294 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 679896002295 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 679896002296 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 679896002297 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 679896002298 TPP-binding site [chemical binding]; other site 679896002299 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 679896002300 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 679896002301 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 679896002302 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 679896002303 Walker A/P-loop; other site 679896002304 ATP binding site [chemical binding]; other site 679896002305 Q-loop/lid; other site 679896002306 ABC transporter signature motif; other site 679896002307 Walker B; other site 679896002308 D-loop; other site 679896002309 H-loop/switch region; other site 679896002310 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 679896002311 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 679896002312 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 679896002313 Walker A/P-loop; other site 679896002314 ATP binding site [chemical binding]; other site 679896002315 Q-loop/lid; other site 679896002316 ABC transporter signature motif; other site 679896002317 Walker B; other site 679896002318 D-loop; other site 679896002319 H-loop/switch region; other site 679896002320 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 679896002321 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 679896002322 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 679896002323 shikimate binding site; other site 679896002324 NAD(P) binding site [chemical binding]; other site 679896002325 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 679896002326 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 679896002327 substrate binding pocket [chemical binding]; other site 679896002328 catalytic triad [active] 679896002329 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 679896002330 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 679896002331 active site 679896002332 catalytic residues [active] 679896002333 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 679896002334 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 679896002335 Na binding site [ion binding]; other site 679896002336 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 679896002337 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 679896002338 nucleotide binding site/active site [active] 679896002339 HIT family signature motif; other site 679896002340 catalytic residue [active] 679896002341 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 679896002342 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 679896002343 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 679896002344 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 679896002345 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 679896002346 ATP binding site [chemical binding]; other site 679896002347 Mg++ binding site [ion binding]; other site 679896002348 motif III; other site 679896002349 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 679896002350 nucleotide binding region [chemical binding]; other site 679896002351 ATP-binding site [chemical binding]; other site 679896002352 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 679896002353 putative RNA binding site [nucleotide binding]; other site 679896002354 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 679896002355 dimer interface [polypeptide binding]; other site 679896002356 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 679896002357 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 679896002358 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 679896002359 Na binding site [ion binding]; other site 679896002360 SNF2 Helicase protein; Region: DUF3670; pfam12419 679896002361 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 679896002362 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 679896002363 ATP binding site [chemical binding]; other site 679896002364 putative Mg++ binding site [ion binding]; other site 679896002365 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 679896002366 nucleotide binding region [chemical binding]; other site 679896002367 ATP-binding site [chemical binding]; other site 679896002368 Uncharacterized conserved protein [Function unknown]; Region: COG4279 679896002369 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 679896002370 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 679896002371 active site 679896002372 metal binding site [ion binding]; metal-binding site 679896002373 DNA binding site [nucleotide binding] 679896002374 AAA domain; Region: AAA_23; pfam13476 679896002375 Uncharacterized conserved protein [Function unknown]; Region: COG2353 679896002376 Transcriptional regulators [Transcription]; Region: MarR; COG1846 679896002377 MarR family; Region: MarR_2; pfam12802 679896002378 PspC domain; Region: PspC; pfam04024 679896002379 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 679896002380 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 679896002381 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 679896002382 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 679896002383 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 679896002384 Cysteine-rich domain; Region: CCG; pfam02754 679896002385 Cysteine-rich domain; Region: CCG; pfam02754 679896002386 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 679896002387 L-lactate permease; Region: Lactate_perm; cl00701 679896002388 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 679896002389 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 679896002390 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 679896002391 active site 679896002392 HIGH motif; other site 679896002393 KMSK motif region; other site 679896002394 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 679896002395 tRNA binding surface [nucleotide binding]; other site 679896002396 anticodon binding site; other site 679896002397 diaminopimelate decarboxylase; Region: lysA; TIGR01048 679896002398 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 679896002399 active site 679896002400 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 679896002401 substrate binding site [chemical binding]; other site 679896002402 catalytic residues [active] 679896002403 dimer interface [polypeptide binding]; other site 679896002404 homoserine dehydrogenase; Provisional; Region: PRK06349 679896002405 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 679896002406 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 679896002407 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 679896002408 homoserine kinase; Provisional; Region: PRK01212 679896002409 Predicted transcriptional regulator [Transcription]; Region: COG2345 679896002410 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 679896002411 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620 679896002412 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 679896002413 acyl-activating enzyme (AAE) consensus motif; other site 679896002414 AMP binding site [chemical binding]; other site 679896002415 active site 679896002416 CoA binding site [chemical binding]; other site 679896002417 transcription termination factor Rho; Provisional; Region: PRK12678 679896002418 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 679896002419 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 679896002420 RNA binding site [nucleotide binding]; other site 679896002421 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 679896002422 multimer interface [polypeptide binding]; other site 679896002423 Walker A motif; other site 679896002424 ATP binding site [chemical binding]; other site 679896002425 Walker B motif; other site 679896002426 peptide chain release factor 1; Validated; Region: prfA; PRK00591 679896002427 This domain is found in peptide chain release factors; Region: PCRF; smart00937 679896002428 RF-1 domain; Region: RF-1; pfam00472 679896002429 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 679896002430 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 679896002431 S-adenosylmethionine binding site [chemical binding]; other site 679896002432 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 679896002433 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 679896002434 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 679896002435 Mg++ binding site [ion binding]; other site 679896002436 putative catalytic motif [active] 679896002437 substrate binding site [chemical binding]; other site 679896002438 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 679896002439 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 679896002440 F0F1 ATP synthase subunit C; Validated; Region: PRK07874 679896002441 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 679896002442 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 679896002443 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 679896002444 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 679896002445 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 679896002446 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 679896002447 beta subunit interaction interface [polypeptide binding]; other site 679896002448 Walker A motif; other site 679896002449 ATP binding site [chemical binding]; other site 679896002450 Walker B motif; other site 679896002451 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 679896002452 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 679896002453 core domain interface [polypeptide binding]; other site 679896002454 delta subunit interface [polypeptide binding]; other site 679896002455 epsilon subunit interface [polypeptide binding]; other site 679896002456 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 679896002457 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 679896002458 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 679896002459 alpha subunit interaction interface [polypeptide binding]; other site 679896002460 Walker A motif; other site 679896002461 ATP binding site [chemical binding]; other site 679896002462 Walker B motif; other site 679896002463 inhibitor binding site; inhibition site 679896002464 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 679896002465 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 679896002466 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 679896002467 gamma subunit interface [polypeptide binding]; other site 679896002468 epsilon subunit interface [polypeptide binding]; other site 679896002469 LBP interface [polypeptide binding]; other site 679896002470 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 679896002471 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 679896002472 hypothetical protein; Provisional; Region: PRK03298 679896002473 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 679896002474 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 679896002475 dimer interface [polypeptide binding]; other site 679896002476 substrate binding site [chemical binding]; other site 679896002477 metal binding site [ion binding]; metal-binding site 679896002478 Domain of unknown function DUF77; Region: DUF77; pfam01910 679896002479 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 679896002480 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 679896002481 glycogen branching enzyme; Provisional; Region: PRK05402 679896002482 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 679896002483 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 679896002484 active site 679896002485 catalytic site [active] 679896002486 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 679896002487 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 679896002488 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 679896002489 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 679896002490 active site 679896002491 catalytic site [active] 679896002492 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 679896002493 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 679896002494 Walker A/P-loop; other site 679896002495 ATP binding site [chemical binding]; other site 679896002496 ABC transporter signature motif; other site 679896002497 Walker B; other site 679896002498 D-loop; other site 679896002499 H-loop/switch region; other site 679896002500 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 679896002501 Ligand binding site [chemical binding]; other site 679896002502 Electron transfer flavoprotein domain; Region: ETF; pfam01012 679896002503 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 679896002504 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 679896002505 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 679896002506 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 679896002507 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 679896002508 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 679896002509 catalytic residue [active] 679896002510 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 679896002511 S-adenosylmethionine binding site [chemical binding]; other site 679896002512 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 679896002513 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 679896002514 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 679896002515 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 679896002516 active site 679896002517 catalytic site [active] 679896002518 substrate binding site [chemical binding]; other site 679896002519 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 679896002520 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 679896002521 nucleotide binding pocket [chemical binding]; other site 679896002522 K-X-D-G motif; other site 679896002523 catalytic site [active] 679896002524 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 679896002525 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 679896002526 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 679896002527 Dimer interface [polypeptide binding]; other site 679896002528 BRCT sequence motif; other site 679896002529 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 679896002530 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 679896002531 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 679896002532 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 679896002533 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 679896002534 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 679896002535 Major Facilitator Superfamily; Region: MFS_1; pfam07690 679896002536 putative substrate translocation pore; other site 679896002537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 679896002538 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 679896002539 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 679896002540 ABC-ATPase subunit interface; other site 679896002541 dimer interface [polypeptide binding]; other site 679896002542 putative PBP binding regions; other site 679896002543 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 679896002544 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 679896002545 Walker A/P-loop; other site 679896002546 ATP binding site [chemical binding]; other site 679896002547 Q-loop/lid; other site 679896002548 ABC transporter signature motif; other site 679896002549 Walker B; other site 679896002550 D-loop; other site 679896002551 H-loop/switch region; other site 679896002552 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 679896002553 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 679896002554 putative ligand binding residues [chemical binding]; other site 679896002555 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 679896002556 phosphofructokinase; Region: PFK_mixed; TIGR02483 679896002557 active site 679896002558 ADP/pyrophosphate binding site [chemical binding]; other site 679896002559 dimerization interface [polypeptide binding]; other site 679896002560 allosteric effector site; other site 679896002561 fructose-1,6-bisphosphate binding site; other site 679896002562 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 679896002563 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 679896002564 GatB domain; Region: GatB_Yqey; smart00845 679896002565 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 679896002566 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 679896002567 active site 679896002568 catalytic tetrad [active] 679896002569 Lysine efflux permease [General function prediction only]; Region: COG1279 679896002570 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 679896002571 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 679896002572 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 679896002573 dimerization interface [polypeptide binding]; other site 679896002574 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 679896002575 Predicted membrane protein [Function unknown]; Region: COG2259 679896002576 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 679896002577 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 679896002578 Mechanosensitive ion channel; Region: MS_channel; pfam00924 679896002579 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 679896002580 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 679896002581 putative valine binding site [chemical binding]; other site 679896002582 dimer interface [polypeptide binding]; other site 679896002583 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 679896002584 ketol-acid reductoisomerase; Provisional; Region: PRK05479 679896002585 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 679896002586 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 679896002587 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 679896002588 Uncharacterized conserved protein [Function unknown]; Region: COG1479 679896002589 Protein of unknown function DUF262; Region: DUF262; pfam03235 679896002590 Uncharacterized conserved protein [Function unknown]; Region: COG3472 679896002591 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 679896002592 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 679896002593 ligand binding site [chemical binding]; other site 679896002594 NAD binding site [chemical binding]; other site 679896002595 dimerization interface [polypeptide binding]; other site 679896002596 catalytic site [active] 679896002597 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 679896002598 putative L-serine binding site [chemical binding]; other site 679896002599 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 679896002600 tartrate dehydrogenase; Region: TTC; TIGR02089 679896002601 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 679896002602 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 679896002603 ligand binding site [chemical binding]; other site 679896002604 flexible hinge region; other site 679896002605 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 679896002606 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 679896002607 metal binding triad; other site 679896002608 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 679896002609 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 679896002610 active site 679896002611 catalytic site [active] 679896002612 substrate binding site [chemical binding]; other site 679896002613 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 679896002614 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 679896002615 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 679896002616 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 679896002617 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 679896002618 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 679896002619 active site 679896002620 HIGH motif; other site 679896002621 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 679896002622 active site 679896002623 KMSKS motif; other site 679896002624 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 679896002625 biotin synthase; Region: bioB; TIGR00433 679896002626 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 679896002627 FeS/SAM binding site; other site 679896002628 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 679896002629 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 679896002630 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 679896002631 Zn2+ binding site [ion binding]; other site 679896002632 Mg2+ binding site [ion binding]; other site 679896002633 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 679896002634 Transcriptional regulator [Transcription]; Region: IclR; COG1414 679896002635 Bacterial transcriptional regulator; Region: IclR; pfam01614 679896002636 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 679896002637 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 679896002638 substrate binding site [chemical binding]; other site 679896002639 ligand binding site [chemical binding]; other site 679896002640 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 679896002641 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 679896002642 substrate binding site [chemical binding]; other site 679896002643 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 679896002644 active site 679896002645 Ap6A binding site [chemical binding]; other site 679896002646 nudix motif; other site 679896002647 metal binding site [ion binding]; metal-binding site 679896002648 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 679896002649 catalytic core [active] 679896002650 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 679896002651 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 679896002652 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 679896002653 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 679896002654 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 679896002655 ATP-grasp domain; Region: ATP-grasp_4; cl17255 679896002656 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 679896002657 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 679896002658 thiamine monophosphate kinase; Provisional; Region: PRK05731 679896002659 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 679896002660 ATP binding site [chemical binding]; other site 679896002661 dimerization interface [polypeptide binding]; other site 679896002662 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 679896002663 ligand binding site [chemical binding]; other site 679896002664 active site 679896002665 UGI interface [polypeptide binding]; other site 679896002666 catalytic site [active] 679896002667 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 679896002668 DAK2 domain; Region: Dak2; pfam02734 679896002669 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 679896002670 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 679896002671 generic binding surface II; other site 679896002672 ssDNA binding site; other site 679896002673 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 679896002674 ATP binding site [chemical binding]; other site 679896002675 putative Mg++ binding site [ion binding]; other site 679896002676 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 679896002677 nucleotide binding region [chemical binding]; other site 679896002678 ATP-binding site [chemical binding]; other site 679896002679 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 679896002680 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 679896002681 carboxyltransferase (CT) interaction site; other site 679896002682 biotinylation site [posttranslational modification]; other site 679896002683 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 679896002684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 679896002685 S-adenosylmethionine binding site [chemical binding]; other site 679896002686 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 679896002687 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 679896002688 active site 679896002689 (T/H)XGH motif; other site 679896002690 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 679896002691 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 679896002692 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 679896002693 Walker A/P-loop; other site 679896002694 ATP binding site [chemical binding]; other site 679896002695 Q-loop/lid; other site 679896002696 ABC transporter signature motif; other site 679896002697 Walker B; other site 679896002698 D-loop; other site 679896002699 H-loop/switch region; other site 679896002700 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 679896002701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 679896002702 dimer interface [polypeptide binding]; other site 679896002703 conserved gate region; other site 679896002704 putative PBP binding loops; other site 679896002705 ABC-ATPase subunit interface; other site 679896002706 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 679896002707 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 679896002708 substrate binding pocket [chemical binding]; other site 679896002709 membrane-bound complex binding site; other site 679896002710 hinge residues; other site 679896002711 Domain of unknown function (DUF368); Region: DUF368; pfam04018 679896002712 DNA polymerase I; Provisional; Region: PRK05755 679896002713 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 679896002714 active site 679896002715 metal binding site 1 [ion binding]; metal-binding site 679896002716 putative 5' ssDNA interaction site; other site 679896002717 metal binding site 3; metal-binding site 679896002718 metal binding site 2 [ion binding]; metal-binding site 679896002719 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 679896002720 putative DNA binding site [nucleotide binding]; other site 679896002721 putative metal binding site [ion binding]; other site 679896002722 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 679896002723 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 679896002724 active site 679896002725 DNA binding site [nucleotide binding] 679896002726 catalytic site [active] 679896002727 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 679896002728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 679896002729 S-adenosylmethionine binding site [chemical binding]; other site 679896002730 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 679896002731 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 679896002732 RNA binding site [nucleotide binding]; other site 679896002733 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 679896002734 RNA binding site [nucleotide binding]; other site 679896002735 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 679896002736 RNA binding site [nucleotide binding]; other site 679896002737 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 679896002738 RNA binding site [nucleotide binding]; other site 679896002739 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 679896002740 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 679896002741 active site turn [active] 679896002742 phosphorylation site [posttranslational modification] 679896002743 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 679896002744 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 679896002745 HPr interaction site; other site 679896002746 glycerol kinase (GK) interaction site [polypeptide binding]; other site 679896002747 active site 679896002748 phosphorylation site [posttranslational modification] 679896002749 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 679896002750 ATP-binding [chemical binding]; other site 679896002751 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 679896002752 CoA-binding site [chemical binding]; other site 679896002753 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 679896002754 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 679896002755 FeS/SAM binding site; other site 679896002756 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 679896002757 excinuclease ABC subunit B; Provisional; Region: PRK05298 679896002758 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 679896002759 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 679896002760 nucleotide binding region [chemical binding]; other site 679896002761 ATP-binding site [chemical binding]; other site 679896002762 Ultra-violet resistance protein B; Region: UvrB; pfam12344 679896002763 UvrB/uvrC motif; Region: UVR; pfam02151 679896002764 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 679896002765 Ligand Binding Site [chemical binding]; other site 679896002766 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 679896002767 Part of AAA domain; Region: AAA_19; pfam13245 679896002768 Family description; Region: UvrD_C_2; pfam13538 679896002769 Predicted membrane protein [Function unknown]; Region: COG2259 679896002770 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 679896002771 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 679896002772 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 679896002773 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 679896002774 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 679896002775 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 679896002776 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 679896002777 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 679896002778 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 679896002779 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 679896002780 23S rRNA binding site [nucleotide binding]; other site 679896002781 L21 binding site [polypeptide binding]; other site 679896002782 L13 binding site [polypeptide binding]; other site 679896002783 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 679896002784 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 679896002785 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 679896002786 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 679896002787 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 679896002788 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 679896002789 dimer interface [polypeptide binding]; other site 679896002790 motif 1; other site 679896002791 active site 679896002792 motif 2; other site 679896002793 motif 3; other site 679896002794 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 679896002795 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 679896002796 putative tRNA-binding site [nucleotide binding]; other site 679896002797 B3/4 domain; Region: B3_4; pfam03483 679896002798 tRNA synthetase B5 domain; Region: B5; smart00874 679896002799 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 679896002800 dimer interface [polypeptide binding]; other site 679896002801 motif 1; other site 679896002802 motif 3; other site 679896002803 motif 2; other site 679896002804 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 679896002805 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 679896002806 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 679896002807 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 679896002808 heterotetramer interface [polypeptide binding]; other site 679896002809 active site pocket [active] 679896002810 cleavage site 679896002811 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 679896002812 feedback inhibition sensing region; other site 679896002813 homohexameric interface [polypeptide binding]; other site 679896002814 nucleotide binding site [chemical binding]; other site 679896002815 N-acetyl-L-glutamate binding site [chemical binding]; other site 679896002816 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 679896002817 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 679896002818 inhibitor-cofactor binding pocket; inhibition site 679896002819 pyridoxal 5'-phosphate binding site [chemical binding]; other site 679896002820 catalytic residue [active] 679896002821 ornithine carbamoyltransferase; Provisional; Region: PRK00779 679896002822 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 679896002823 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 679896002824 arginine repressor; Provisional; Region: PRK03341 679896002825 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 679896002826 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 679896002827 argininosuccinate synthase; Provisional; Region: PRK13820 679896002828 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 679896002829 ANP binding site [chemical binding]; other site 679896002830 Substrate Binding Site II [chemical binding]; other site 679896002831 Substrate Binding Site I [chemical binding]; other site 679896002832 argininosuccinate lyase; Provisional; Region: PRK00855 679896002833 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 679896002834 active sites [active] 679896002835 tetramer interface [polypeptide binding]; other site 679896002836 Uncharacterized conserved protein [Function unknown]; Region: COG2835 679896002837 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 679896002838 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 679896002839 active site 679896002840 HIGH motif; other site 679896002841 dimer interface [polypeptide binding]; other site 679896002842 KMSKS motif; other site 679896002843 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 679896002844 RNA binding surface [nucleotide binding]; other site 679896002845 transcription termination factor Rho; Provisional; Region: PRK12678 679896002846 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 679896002847 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 679896002848 active site 679896002849 motif I; other site 679896002850 motif II; other site 679896002851 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 679896002852 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 679896002853 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 679896002854 RNA binding surface [nucleotide binding]; other site 679896002855 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 679896002856 S-adenosylmethionine binding site [chemical binding]; other site 679896002857 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 679896002858 ATP-NAD kinase; Region: NAD_kinase; pfam01513 679896002859 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 679896002860 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 679896002861 Walker A/P-loop; other site 679896002862 ATP binding site [chemical binding]; other site 679896002863 Q-loop/lid; other site 679896002864 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 679896002865 ABC transporter signature motif; other site 679896002866 Walker B; other site 679896002867 D-loop; other site 679896002868 H-loop/switch region; other site 679896002869 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 679896002870 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 679896002871 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 679896002872 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 679896002873 dimer interface [polypeptide binding]; other site 679896002874 ADP-ribose binding site [chemical binding]; other site 679896002875 active site 679896002876 nudix motif; other site 679896002877 metal binding site [ion binding]; metal-binding site 679896002878 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 679896002879 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 679896002880 active site 679896002881 Int/Topo IB signature motif; other site 679896002882 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 679896002883 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 679896002884 P-loop; other site 679896002885 Magnesium ion binding site [ion binding]; other site 679896002886 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 679896002887 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 679896002888 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 679896002889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 679896002890 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05630 679896002891 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 679896002892 inhibitor-cofactor binding pocket; inhibition site 679896002893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 679896002894 catalytic residue [active] 679896002895 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 679896002896 AAA domain; Region: AAA_26; pfam13500 679896002897 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 679896002898 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 679896002899 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 679896002900 RNA binding surface [nucleotide binding]; other site 679896002901 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 679896002902 active site 679896002903 cytidylate kinase; Provisional; Region: cmk; PRK00023 679896002904 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 679896002905 CMP-binding site; other site 679896002906 The sites determining sugar specificity; other site 679896002907 GTP-binding protein Der; Reviewed; Region: PRK03003 679896002908 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 679896002909 G1 box; other site 679896002910 GTP/Mg2+ binding site [chemical binding]; other site 679896002911 Switch I region; other site 679896002912 G2 box; other site 679896002913 Switch II region; other site 679896002914 G3 box; other site 679896002915 G4 box; other site 679896002916 G5 box; other site 679896002917 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 679896002918 G1 box; other site 679896002919 GTP/Mg2+ binding site [chemical binding]; other site 679896002920 Switch I region; other site 679896002921 G2 box; other site 679896002922 G3 box; other site 679896002923 Switch II region; other site 679896002924 G4 box; other site 679896002925 G5 box; other site 679896002926 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 679896002927 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 679896002928 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 679896002929 S-adenosylmethionine binding site [chemical binding]; other site 679896002930 Predicted esterase [General function prediction only]; Region: COG0627 679896002931 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 679896002932 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 679896002933 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 679896002934 intersubunit interface [polypeptide binding]; other site 679896002935 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 679896002936 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 679896002937 dimer interface [polypeptide binding]; other site 679896002938 ABC-ATPase subunit interface; other site 679896002939 putative PBP binding regions; other site 679896002940 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 679896002941 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 679896002942 ABC-ATPase subunit interface; other site 679896002943 dimer interface [polypeptide binding]; other site 679896002944 putative PBP binding regions; other site 679896002945 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 679896002946 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 679896002947 Walker A/P-loop; other site 679896002948 ATP binding site [chemical binding]; other site 679896002949 Q-loop/lid; other site 679896002950 ABC transporter signature motif; other site 679896002951 Walker B; other site 679896002952 D-loop; other site 679896002953 H-loop/switch region; other site 679896002954 IucA / IucC family; Region: IucA_IucC; pfam04183 679896002955 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 679896002956 IucA / IucC family; Region: IucA_IucC; pfam04183 679896002957 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 679896002958 H+ Antiporter protein; Region: 2A0121; TIGR00900 679896002959 hypothetical protein; Provisional; Region: PRK01842 679896002960 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 679896002961 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 679896002962 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 679896002963 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 679896002964 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 679896002965 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 679896002966 nucleotide binding region [chemical binding]; other site 679896002967 ATP-binding site [chemical binding]; other site 679896002968 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 679896002969 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 679896002970 phosphopeptide binding site; other site 679896002971 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 679896002972 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 679896002973 DNA binding residues [nucleotide binding] 679896002974 Bifunctional nuclease; Region: DNase-RNase; pfam02577 679896002975 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 679896002976 DNA binding residues [nucleotide binding] 679896002977 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 679896002978 putative dimer interface [polypeptide binding]; other site 679896002979 Domain of unknown function DUF21; Region: DUF21; pfam01595 679896002980 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 679896002981 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 679896002982 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 679896002983 Domain of unknown function DUF21; Region: DUF21; pfam01595 679896002984 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 679896002985 Transporter associated domain; Region: CorC_HlyC; smart01091 679896002986 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 679896002987 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 679896002988 ATP binding site [chemical binding]; other site 679896002989 putative Mg++ binding site [ion binding]; other site 679896002990 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 679896002991 nucleotide binding region [chemical binding]; other site 679896002992 ATP-binding site [chemical binding]; other site 679896002993 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 679896002994 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 679896002995 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 679896002996 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 679896002997 CoenzymeA binding site [chemical binding]; other site 679896002998 subunit interaction site [polypeptide binding]; other site 679896002999 PHB binding site; other site 679896003000 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 679896003001 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 679896003002 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 679896003003 oligomer interface [polypeptide binding]; other site 679896003004 metal binding site [ion binding]; metal-binding site 679896003005 metal binding site [ion binding]; metal-binding site 679896003006 putative Cl binding site [ion binding]; other site 679896003007 basic sphincter; other site 679896003008 hydrophobic gate; other site 679896003009 periplasmic entrance; other site 679896003010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 679896003011 S-adenosylmethionine binding site [chemical binding]; other site 679896003012 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 679896003013 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 679896003014 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 679896003015 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 679896003016 metabolite-proton symporter; Region: 2A0106; TIGR00883 679896003017 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 679896003018 putative substrate translocation pore; other site 679896003019 YceI-like domain; Region: YceI; pfam04264 679896003020 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 679896003021 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 679896003022 Ligand binding site; other site 679896003023 Putative Catalytic site; other site 679896003024 DXD motif; other site 679896003025 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 679896003026 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 679896003027 putative active site [active] 679896003028 catalytic triad [active] 679896003029 putative dimer interface [polypeptide binding]; other site 679896003030 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 679896003031 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 679896003032 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 679896003033 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 679896003034 precorrin-3B synthase; Region: CobG; TIGR02435 679896003035 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 679896003036 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 679896003037 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 679896003038 Precorrin-8X methylmutase; Region: CbiC; pfam02570 679896003039 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 679896003040 active site 679896003041 SAM binding site [chemical binding]; other site 679896003042 homodimer interface [polypeptide binding]; other site 679896003043 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 679896003044 active site 679896003045 SAM binding site [chemical binding]; other site 679896003046 homodimer interface [polypeptide binding]; other site 679896003047 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 679896003048 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 679896003049 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 679896003050 active site 679896003051 SAM binding site [chemical binding]; other site 679896003052 homodimer interface [polypeptide binding]; other site 679896003053 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 679896003054 active site 679896003055 putative homodimer interface [polypeptide binding]; other site 679896003056 SAM binding site [chemical binding]; other site 679896003057 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 679896003058 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 679896003059 S-adenosylmethionine binding site [chemical binding]; other site 679896003060 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 679896003061 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 679896003062 NAD(P) binding site [chemical binding]; other site 679896003063 active site 679896003064 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 679896003065 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 679896003066 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 679896003067 active site 679896003068 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 679896003069 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 679896003070 ATP binding site [chemical binding]; other site 679896003071 putative Mg++ binding site [ion binding]; other site 679896003072 helicase superfamily c-terminal domain; Region: HELICc; smart00490 679896003073 nucleotide binding region [chemical binding]; other site 679896003074 ATP-binding site [chemical binding]; other site 679896003075 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 679896003076 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 679896003077 twin arginine translocase protein A; Provisional; Region: tatA; PRK00191 679896003078 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 679896003079 Predicted transcriptional regulator [Transcription]; Region: COG2378 679896003080 WYL domain; Region: WYL; pfam13280 679896003081 Predicted transcriptional regulator [Transcription]; Region: COG2378 679896003082 WYL domain; Region: WYL; pfam13280 679896003083 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 679896003084 Pup-like protein; Region: Pup; pfam05639 679896003085 Pup-ligase protein; Region: Pup_ligase; cl15463 679896003086 proteasome ATPase; Region: pup_AAA; TIGR03689 679896003087 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 679896003088 Walker A motif; other site 679896003089 ATP binding site [chemical binding]; other site 679896003090 Walker B motif; other site 679896003091 arginine finger; other site 679896003092 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 679896003093 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 679896003094 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 679896003095 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 679896003096 active site 679896003097 metal binding site [ion binding]; metal-binding site 679896003098 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 679896003099 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 679896003100 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 679896003101 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 679896003102 Potassium binding sites [ion binding]; other site 679896003103 Cesium cation binding sites [ion binding]; other site 679896003104 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 679896003105 Aspartase; Region: Aspartase; cd01357 679896003106 active sites [active] 679896003107 tetramer interface [polypeptide binding]; other site 679896003108 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 679896003109 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 679896003110 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 679896003111 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 679896003112 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 679896003113 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 679896003114 homodimer interface [polypeptide binding]; other site 679896003115 putative metal binding site [ion binding]; other site 679896003116 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 679896003117 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 679896003118 motif II; other site 679896003119 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 679896003120 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 679896003121 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 679896003122 substrate binding pocket [chemical binding]; other site 679896003123 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 679896003124 B12 binding site [chemical binding]; other site 679896003125 cobalt ligand [ion binding]; other site 679896003126 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 679896003127 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 679896003128 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 679896003129 active site 679896003130 HIGH motif; other site 679896003131 nucleotide binding site [chemical binding]; other site 679896003132 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 679896003133 active site 679896003134 KMSKS motif; other site 679896003135 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 679896003136 tRNA binding surface [nucleotide binding]; other site 679896003137 anticodon binding site; other site 679896003138 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 679896003139 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 679896003140 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 679896003141 active site 679896003142 catalytic tetrad [active] 679896003143 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 679896003144 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 679896003145 quinone interaction residues [chemical binding]; other site 679896003146 active site 679896003147 catalytic residues [active] 679896003148 FMN binding site [chemical binding]; other site 679896003149 substrate binding site [chemical binding]; other site 679896003150 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 679896003151 substrate binding site [chemical binding]; other site 679896003152 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 679896003153 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 679896003154 dimerization domain swap beta strand [polypeptide binding]; other site 679896003155 regulatory protein interface [polypeptide binding]; other site 679896003156 active site 679896003157 regulatory phosphorylation site [posttranslational modification]; other site 679896003158 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 679896003159 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 679896003160 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 679896003161 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 679896003162 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 679896003163 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 679896003164 NAD(P) binding site [chemical binding]; other site 679896003165 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 679896003166 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 679896003167 NAD(P) binding site [chemical binding]; other site 679896003168 active site 679896003169 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 679896003170 GTP/Mg2+ binding site [chemical binding]; other site 679896003171 G4 box; other site 679896003172 membrane ATPase/protein kinase; Provisional; Region: PRK09435 679896003173 G5 box; other site 679896003174 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 679896003175 Walker A; other site 679896003176 G1 box; other site 679896003177 Switch I region; other site 679896003178 G2 box; other site 679896003179 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 679896003180 G4 box; other site 679896003181 G5 box; other site 679896003182 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 679896003183 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 679896003184 active site 679896003185 substrate binding site [chemical binding]; other site 679896003186 coenzyme B12 binding site [chemical binding]; other site 679896003187 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 679896003188 B12 binding site [chemical binding]; other site 679896003189 cobalt ligand [ion binding]; other site 679896003190 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 679896003191 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 679896003192 heterodimer interface [polypeptide binding]; other site 679896003193 substrate interaction site [chemical binding]; other site 679896003194 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 679896003195 Uncharacterized conserved protein [Function unknown]; Region: COG0398 679896003196 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 679896003197 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 679896003198 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 679896003199 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 679896003200 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 679896003201 ferrochelatase; Reviewed; Region: hemH; PRK00035 679896003202 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 679896003203 C-terminal domain interface [polypeptide binding]; other site 679896003204 active site 679896003205 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 679896003206 active site 679896003207 N-terminal domain interface [polypeptide binding]; other site 679896003208 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 679896003209 NlpC/P60 family; Region: NLPC_P60; pfam00877 679896003210 pyruvate carboxylase subunit A; Validated; Region: PRK07178 679896003211 aconitate hydratase; Validated; Region: PRK09277 679896003212 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 679896003213 substrate binding site [chemical binding]; other site 679896003214 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 679896003215 ligand binding site [chemical binding]; other site 679896003216 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 679896003217 substrate binding site [chemical binding]; other site 679896003218 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 679896003219 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 679896003220 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 679896003221 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cd03128 679896003222 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 679896003223 catalytic triad [active] 679896003224 conserved cys residue [active] 679896003225 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 679896003226 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 679896003227 AAA ATPase domain; Region: AAA_16; pfam13191 679896003228 AAA domain; Region: AAA_22; pfam13401 679896003229 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 679896003230 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 679896003231 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 679896003232 Walker A/P-loop; other site 679896003233 ATP binding site [chemical binding]; other site 679896003234 Q-loop/lid; other site 679896003235 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 679896003236 ABC transporter signature motif; other site 679896003237 Walker B; other site 679896003238 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 679896003239 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 679896003240 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 679896003241 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 679896003242 trimerization site [polypeptide binding]; other site 679896003243 active site 679896003244 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 679896003245 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 679896003246 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 679896003247 catalytic residue [active] 679896003248 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 679896003249 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 679896003250 Walker A/P-loop; other site 679896003251 ATP binding site [chemical binding]; other site 679896003252 Q-loop/lid; other site 679896003253 ABC transporter signature motif; other site 679896003254 Walker B; other site 679896003255 D-loop; other site 679896003256 H-loop/switch region; other site 679896003257 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 679896003258 FeS assembly protein SufD; Region: sufD; TIGR01981 679896003259 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 679896003260 FeS assembly protein SufB; Region: sufB; TIGR01980 679896003261 Predicted transcriptional regulator [Transcription]; Region: COG2345 679896003262 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 679896003263 putative DNA binding site [nucleotide binding]; other site 679896003264 putative Zn2+ binding site [ion binding]; other site 679896003265 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 679896003266 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 679896003267 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 679896003268 Walker A/P-loop; other site 679896003269 ATP binding site [chemical binding]; other site 679896003270 Q-loop/lid; other site 679896003271 ABC transporter signature motif; other site 679896003272 Walker B; other site 679896003273 D-loop; other site 679896003274 H-loop/switch region; other site 679896003275 ABC-2 type transporter; Region: ABC2_membrane; cl17235 679896003276 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 679896003277 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 679896003278 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 679896003279 UbiA prenyltransferase family; Region: UbiA; pfam01040 679896003280 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 679896003281 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 679896003282 TPP-binding site [chemical binding]; other site 679896003283 dimer interface [polypeptide binding]; other site 679896003284 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 679896003285 PYR/PP interface [polypeptide binding]; other site 679896003286 dimer interface [polypeptide binding]; other site 679896003287 TPP binding site [chemical binding]; other site 679896003288 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 679896003289 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 679896003290 putative active site [active] 679896003291 transaldolase; Provisional; Region: PRK03903 679896003292 catalytic residue [active] 679896003293 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 679896003294 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 679896003295 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 679896003296 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 679896003297 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 679896003298 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 679896003299 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 679896003300 putative active site [active] 679896003301 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 679896003302 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 679896003303 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 679896003304 triosephosphate isomerase; Provisional; Region: PRK14567 679896003305 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 679896003306 substrate binding site [chemical binding]; other site 679896003307 dimer interface [polypeptide binding]; other site 679896003308 catalytic triad [active] 679896003309 Phosphoglycerate kinase; Region: PGK; pfam00162 679896003310 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 679896003311 substrate binding site [chemical binding]; other site 679896003312 hinge regions; other site 679896003313 ADP binding site [chemical binding]; other site 679896003314 catalytic site [active] 679896003315 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 679896003316 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 679896003317 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 679896003318 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 679896003319 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 679896003320 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 679896003321 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 679896003322 phosphate binding site [ion binding]; other site 679896003323 putative substrate binding pocket [chemical binding]; other site 679896003324 dimer interface [polypeptide binding]; other site 679896003325 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 679896003326 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 679896003327 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 679896003328 GIY-YIG motif/motif A; other site 679896003329 active site 679896003330 catalytic site [active] 679896003331 putative DNA binding site [nucleotide binding]; other site 679896003332 metal binding site [ion binding]; metal-binding site 679896003333 UvrB/uvrC motif; Region: UVR; pfam02151 679896003334 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 679896003335 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 679896003336 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 679896003337 homopentamer interface [polypeptide binding]; other site 679896003338 active site 679896003339 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 679896003340 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 679896003341 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 679896003342 dimerization interface [polypeptide binding]; other site 679896003343 active site 679896003344 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 679896003345 Lumazine binding domain; Region: Lum_binding; pfam00677 679896003346 Lumazine binding domain; Region: Lum_binding; pfam00677 679896003347 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 679896003348 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 679896003349 catalytic motif [active] 679896003350 Zn binding site [ion binding]; other site 679896003351 RibD C-terminal domain; Region: RibD_C; pfam01872 679896003352 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 679896003353 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 679896003354 substrate binding site [chemical binding]; other site 679896003355 hexamer interface [polypeptide binding]; other site 679896003356 metal binding site [ion binding]; metal-binding site 679896003357 16S rRNA methyltransferase B; Provisional; Region: PRK14902 679896003358 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 679896003359 putative RNA binding site [nucleotide binding]; other site 679896003360 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 679896003361 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 679896003362 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 679896003363 putative active site [active] 679896003364 substrate binding site [chemical binding]; other site 679896003365 putative cosubstrate binding site; other site 679896003366 catalytic site [active] 679896003367 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 679896003368 substrate binding site [chemical binding]; other site 679896003369 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 679896003370 active site 679896003371 catalytic residues [active] 679896003372 metal binding site [ion binding]; metal-binding site 679896003373 primosome assembly protein PriA; Provisional; Region: PRK14873 679896003374 S-adenosylmethionine synthetase; Validated; Region: PRK05250 679896003375 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 679896003376 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 679896003377 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 679896003378 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 679896003379 Flavoprotein; Region: Flavoprotein; pfam02441 679896003380 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 679896003381 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 679896003382 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 679896003383 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 679896003384 catalytic site [active] 679896003385 G-X2-G-X-G-K; other site 679896003386 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 679896003387 active site 679896003388 dimer interface [polypeptide binding]; other site 679896003389 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 679896003390 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 679896003391 ATP-grasp domain; Region: ATP-grasp_4; cl17255 679896003392 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 679896003393 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 679896003394 ATP-grasp domain; Region: ATP-grasp_4; cl17255 679896003395 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 679896003396 IMP binding site; other site 679896003397 dimer interface [polypeptide binding]; other site 679896003398 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 679896003399 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 679896003400 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 679896003401 catalytic site [active] 679896003402 subunit interface [polypeptide binding]; other site 679896003403 dihydroorotase; Validated; Region: pyrC; PRK09357 679896003404 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 679896003405 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 679896003406 active site 679896003407 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 679896003408 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 679896003409 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 679896003410 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 679896003411 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 679896003412 active site 679896003413 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 679896003414 putative hydrophobic ligand binding site [chemical binding]; other site 679896003415 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 679896003416 TIGR01777 family protein; Region: yfcH 679896003417 NAD(P) binding site [chemical binding]; other site 679896003418 active site 679896003419 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 679896003420 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 679896003421 putative RNA binding site [nucleotide binding]; other site 679896003422 elongation factor P; Validated; Region: PRK00529 679896003423 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 679896003424 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 679896003425 RNA binding site [nucleotide binding]; other site 679896003426 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 679896003427 RNA binding site [nucleotide binding]; other site 679896003428 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 679896003429 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 679896003430 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 679896003431 active site 679896003432 Dehydroquinase class II; Region: DHquinase_II; pfam01220 679896003433 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 679896003434 trimer interface [polypeptide binding]; other site 679896003435 active site 679896003436 dimer interface [polypeptide binding]; other site 679896003437 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 679896003438 active site 679896003439 dimer interface [polypeptide binding]; other site 679896003440 metal binding site [ion binding]; metal-binding site 679896003441 shikimate kinase; Reviewed; Region: aroK; PRK00131 679896003442 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 679896003443 ADP binding site [chemical binding]; other site 679896003444 magnesium binding site [ion binding]; other site 679896003445 putative shikimate binding site; other site 679896003446 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 679896003447 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 679896003448 Tetramer interface [polypeptide binding]; other site 679896003449 active site 679896003450 FMN-binding site [chemical binding]; other site 679896003451 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 679896003452 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 679896003453 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 679896003454 shikimate binding site; other site 679896003455 NAD(P) binding site [chemical binding]; other site 679896003456 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 679896003457 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 679896003458 dimerization interface [polypeptide binding]; other site 679896003459 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 679896003460 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 679896003461 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 679896003462 motif 1; other site 679896003463 active site 679896003464 motif 2; other site 679896003465 motif 3; other site 679896003466 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 679896003467 DHHA1 domain; Region: DHHA1; pfam02272 679896003468 recombination factor protein RarA; Reviewed; Region: PRK13342 679896003469 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 679896003470 Walker A motif; other site 679896003471 ATP binding site [chemical binding]; other site 679896003472 Walker B motif; other site 679896003473 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 679896003474 Phosphotransferase enzyme family; Region: APH; pfam01636 679896003475 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 679896003476 substrate binding site [chemical binding]; other site 679896003477 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 679896003478 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 679896003479 dimer interface [polypeptide binding]; other site 679896003480 anticodon binding site; other site 679896003481 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 679896003482 homodimer interface [polypeptide binding]; other site 679896003483 motif 1; other site 679896003484 active site 679896003485 motif 2; other site 679896003486 GAD domain; Region: GAD; pfam02938 679896003487 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 679896003488 active site 679896003489 motif 3; other site 679896003490 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 679896003491 DEAD-like helicases superfamily; Region: DEXDc; smart00487 679896003492 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 679896003493 ATP binding site [chemical binding]; other site 679896003494 putative Mg++ binding site [ion binding]; other site 679896003495 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 679896003496 nucleotide binding region [chemical binding]; other site 679896003497 ATP-binding site [chemical binding]; other site 679896003498 Predicted membrane protein [Function unknown]; Region: COG1511 679896003499 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 679896003500 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 679896003501 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 679896003502 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 679896003503 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 679896003504 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 679896003505 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 679896003506 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 679896003507 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 679896003508 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 679896003509 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 679896003510 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 679896003511 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 679896003512 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 679896003513 putative active site [active] 679896003514 putative catalytic site [active] 679896003515 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 679896003516 CoA-transferase family III; Region: CoA_transf_3; pfam02515 679896003517 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 679896003518 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 679896003519 dimer interface [polypeptide binding]; other site 679896003520 motif 1; other site 679896003521 active site 679896003522 motif 2; other site 679896003523 motif 3; other site 679896003524 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 679896003525 anticodon binding site; other site 679896003526 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 679896003527 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 679896003528 dimer interface [polypeptide binding]; other site 679896003529 catalytic triad [active] 679896003530 peroxidatic and resolving cysteines [active] 679896003531 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 679896003532 active site 679896003533 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 679896003534 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 679896003535 Zn2+ binding site [ion binding]; other site 679896003536 Mg2+ binding site [ion binding]; other site 679896003537 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 679896003538 synthetase active site [active] 679896003539 NTP binding site [chemical binding]; other site 679896003540 metal binding site [ion binding]; metal-binding site 679896003541 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 679896003542 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 679896003543 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 679896003544 active site 679896003545 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 679896003546 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 679896003547 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 679896003548 Protein export membrane protein; Region: SecD_SecF; pfam02355 679896003549 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 679896003550 Protein export membrane protein; Region: SecD_SecF; cl14618 679896003551 Preprotein translocase subunit; Region: YajC; pfam02699 679896003552 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 679896003553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 679896003554 Walker A motif; other site 679896003555 ATP binding site [chemical binding]; other site 679896003556 Walker B motif; other site 679896003557 arginine finger; other site 679896003558 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 679896003559 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 679896003560 RuvA N terminal domain; Region: RuvA_N; pfam01330 679896003561 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 679896003562 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 679896003563 active site 679896003564 putative DNA-binding cleft [nucleotide binding]; other site 679896003565 dimer interface [polypeptide binding]; other site 679896003566 hypothetical protein; Validated; Region: PRK00110 679896003567 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 679896003568 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 679896003569 active site 679896003570 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 679896003571 catalytic triad [active] 679896003572 dimer interface [polypeptide binding]; other site 679896003573 Protein of unknown function (DUF998); Region: DUF998; pfam06197 679896003574 6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322 679896003575 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 679896003576 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 679896003577 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 679896003578 catalytic residue [active] 679896003579 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 679896003580 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 679896003581 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 679896003582 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 679896003583 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 679896003584 putative acyl-acceptor binding pocket; other site 679896003585 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 679896003586 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 679896003587 nucleotide binding site/active site [active] 679896003588 HIT family signature motif; other site 679896003589 catalytic residue [active] 679896003590 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 679896003591 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 679896003592 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 679896003593 active site 679896003594 dimer interface [polypeptide binding]; other site 679896003595 motif 1; other site 679896003596 motif 2; other site 679896003597 motif 3; other site 679896003598 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 679896003599 anticodon binding site; other site 679896003600 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 679896003601 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 679896003602 Protein of unknown function (DUF461); Region: DUF461; pfam04314 679896003603 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 679896003604 hypothetical protein; Provisional; Region: PRK14059 679896003605 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 679896003606 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 679896003607 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 679896003608 SelR domain; Region: SelR; pfam01641 679896003609 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 679896003610 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 679896003611 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 679896003612 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 679896003613 catalytic site [active] 679896003614 putative active site [active] 679896003615 putative substrate binding site [chemical binding]; other site 679896003616 HRDC domain; Region: HRDC; pfam00570 679896003617 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 679896003618 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 679896003619 TPP-binding site; other site 679896003620 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 679896003621 PYR/PP interface [polypeptide binding]; other site 679896003622 dimer interface [polypeptide binding]; other site 679896003623 TPP binding site [chemical binding]; other site 679896003624 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 679896003625 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 679896003626 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 679896003627 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 679896003628 S-adenosylmethionine binding site [chemical binding]; other site 679896003629 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 679896003630 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 679896003631 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 679896003632 trimer interface [polypeptide binding]; other site 679896003633 active site 679896003634 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 679896003635 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 679896003636 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 679896003637 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 679896003638 nucleotide binding site [chemical binding]; other site 679896003639 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 679896003640 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 679896003641 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 679896003642 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 679896003643 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 679896003644 DNA binding residues [nucleotide binding] 679896003645 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 679896003646 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 679896003647 ATP binding site [chemical binding]; other site 679896003648 putative Mg++ binding site [ion binding]; other site 679896003649 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 679896003650 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 679896003651 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 679896003652 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 679896003653 S-adenosylmethionine binding site [chemical binding]; other site 679896003654 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 679896003655 putative active site [active] 679896003656 dimerization interface [polypeptide binding]; other site 679896003657 putative tRNAtyr binding site [nucleotide binding]; other site 679896003658 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 679896003659 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 679896003660 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 679896003661 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 679896003662 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 679896003663 DNA binding residues [nucleotide binding] 679896003664 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 679896003665 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 679896003666 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 679896003667 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 679896003668 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 679896003669 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 679896003670 NAD binding site [chemical binding]; other site 679896003671 homodimer interface [polypeptide binding]; other site 679896003672 active site 679896003673 substrate binding site [chemical binding]; other site 679896003674 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 679896003675 PAC2 family; Region: PAC2; pfam09754 679896003676 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 679896003677 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 679896003678 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 679896003679 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 679896003680 dimer interface [polypeptide binding]; other site 679896003681 decamer (pentamer of dimers) interface [polypeptide binding]; other site 679896003682 catalytic triad [active] 679896003683 peroxidatic and resolving cysteines [active] 679896003684 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 679896003685 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 679896003686 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 679896003687 dimerization interface [polypeptide binding]; other site 679896003688 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 679896003689 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 679896003690 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 679896003691 ATP binding site [chemical binding]; other site 679896003692 putative Mg++ binding site [ion binding]; other site 679896003693 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 679896003694 nucleotide binding region [chemical binding]; other site 679896003695 ATP-binding site [chemical binding]; other site 679896003696 Helicase associated domain (HA2); Region: HA2; pfam04408 679896003697 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 679896003698 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 679896003699 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 679896003700 ATP cone domain; Region: ATP-cone; pfam03477 679896003701 LexA repressor; Validated; Region: PRK00215 679896003702 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 679896003703 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 679896003704 Catalytic site [active] 679896003705 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 679896003706 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 679896003707 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 679896003708 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 679896003709 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 679896003710 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 679896003711 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 679896003712 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 679896003713 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 679896003714 DNA-binding site [nucleotide binding]; DNA binding site 679896003715 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 679896003716 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 679896003717 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 679896003718 putative substrate binding site [chemical binding]; other site 679896003719 putative ATP binding site [chemical binding]; other site 679896003720 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 679896003721 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 679896003722 active site 679896003723 phosphorylation site [posttranslational modification] 679896003724 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 679896003725 active site 679896003726 P-loop; other site 679896003727 phosphorylation site [posttranslational modification] 679896003728 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 679896003729 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 679896003730 dimerization domain swap beta strand [polypeptide binding]; other site 679896003731 regulatory protein interface [polypeptide binding]; other site 679896003732 active site 679896003733 regulatory phosphorylation site [posttranslational modification]; other site 679896003734 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 679896003735 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 679896003736 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 679896003737 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 679896003738 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 679896003739 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 679896003740 GTPases [General function prediction only]; Region: HflX; COG2262 679896003741 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 679896003742 HflX GTPase family; Region: HflX; cd01878 679896003743 G1 box; other site 679896003744 GTP/Mg2+ binding site [chemical binding]; other site 679896003745 Switch I region; other site 679896003746 G2 box; other site 679896003747 G3 box; other site 679896003748 Switch II region; other site 679896003749 G4 box; other site 679896003750 G5 box; other site 679896003751 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 679896003752 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 679896003753 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 679896003754 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 679896003755 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 679896003756 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 679896003757 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 679896003758 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 679896003759 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 679896003760 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 679896003761 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 679896003762 FeS/SAM binding site; other site 679896003763 recombination regulator RecX; Reviewed; Region: recX; PRK00117 679896003764 recombinase A; Provisional; Region: recA; PRK09354 679896003765 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 679896003766 hexamer interface [polypeptide binding]; other site 679896003767 Walker A motif; other site 679896003768 ATP binding site [chemical binding]; other site 679896003769 Walker B motif; other site 679896003770 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 679896003771 BioY family; Region: BioY; pfam02632 679896003772 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 679896003773 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 679896003774 Walker A/P-loop; other site 679896003775 ATP binding site [chemical binding]; other site 679896003776 Q-loop/lid; other site 679896003777 ABC transporter signature motif; other site 679896003778 Walker B; other site 679896003779 D-loop; other site 679896003780 H-loop/switch region; other site 679896003781 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 679896003782 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 679896003783 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 679896003784 sequence-specific DNA binding site [nucleotide binding]; other site 679896003785 salt bridge; other site 679896003786 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 679896003787 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 679896003788 YCII-related domain; Region: YCII; cl00999 679896003789 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 679896003790 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 679896003791 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 679896003792 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 679896003793 TIGR03085 family protein; Region: TIGR03085 679896003794 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 679896003795 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 679896003796 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 679896003797 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 679896003798 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 679896003799 dimer interface [polypeptide binding]; other site 679896003800 active site 679896003801 catalytic residue [active] 679896003802 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 679896003803 dihydrodipicolinate reductase; Provisional; Region: PRK00048 679896003804 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 679896003805 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 679896003806 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 679896003807 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 679896003808 oligomer interface [polypeptide binding]; other site 679896003809 RNA binding site [nucleotide binding]; other site 679896003810 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 679896003811 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 679896003812 RNase E interface [polypeptide binding]; other site 679896003813 trimer interface [polypeptide binding]; other site 679896003814 active site 679896003815 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 679896003816 putative nucleic acid binding region [nucleotide binding]; other site 679896003817 G-X-X-G motif; other site 679896003818 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 679896003819 RNA binding site [nucleotide binding]; other site 679896003820 domain interface; other site 679896003821 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 679896003822 16S/18S rRNA binding site [nucleotide binding]; other site 679896003823 S13e-L30e interaction site [polypeptide binding]; other site 679896003824 25S rRNA binding site [nucleotide binding]; other site 679896003825 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 679896003826 active site 679896003827 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 679896003828 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 679896003829 active site 679896003830 Riboflavin kinase; Region: Flavokinase; smart00904 679896003831 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 679896003832 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 679896003833 RNA binding site [nucleotide binding]; other site 679896003834 active site 679896003835 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 679896003836 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 679896003837 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 679896003838 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 679896003839 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 679896003840 active site 679896003841 metal binding site [ion binding]; metal-binding site 679896003842 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 679896003843 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 679896003844 DHH family; Region: DHH; pfam01368 679896003845 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 679896003846 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 679896003847 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 679896003848 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 679896003849 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 679896003850 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 679896003851 G1 box; other site 679896003852 putative GEF interaction site [polypeptide binding]; other site 679896003853 GTP/Mg2+ binding site [chemical binding]; other site 679896003854 Switch I region; other site 679896003855 G2 box; other site 679896003856 G3 box; other site 679896003857 Switch II region; other site 679896003858 G4 box; other site 679896003859 G5 box; other site 679896003860 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 679896003861 Translation-initiation factor 2; Region: IF-2; pfam11987 679896003862 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 679896003863 Protein of unknown function (DUF448); Region: DUF448; pfam04296 679896003864 putative RNA binding cleft [nucleotide binding]; other site 679896003865 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 679896003866 NusA N-terminal domain; Region: NusA_N; pfam08529 679896003867 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 679896003868 RNA binding site [nucleotide binding]; other site 679896003869 homodimer interface [polypeptide binding]; other site 679896003870 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 679896003871 G-X-X-G motif; other site 679896003872 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 679896003873 G-X-X-G motif; other site 679896003874 ribosome maturation protein RimP; Reviewed; Region: PRK00092 679896003875 Sm and related proteins; Region: Sm_like; cl00259 679896003876 prolyl-tRNA synthetase; Provisional; Region: PRK09194 679896003877 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 679896003878 dimer interface [polypeptide binding]; other site 679896003879 motif 1; other site 679896003880 active site 679896003881 motif 2; other site 679896003882 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 679896003883 putative deacylase active site [active] 679896003884 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 679896003885 active site 679896003886 motif 3; other site 679896003887 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 679896003888 anticodon binding site; other site 679896003889 hypothetical protein; Validated; Region: PRK02101 679896003890 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 679896003891 active site 679896003892 SAM binding site [chemical binding]; other site 679896003893 homodimer interface [polypeptide binding]; other site 679896003894 hypothetical protein; Validated; Region: PRK00029 679896003895 Uncharacterized conserved protein [Function unknown]; Region: COG0397 679896003896 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 679896003897 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 679896003898 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 679896003899 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 679896003900 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 679896003901 DNA binding site [nucleotide binding] 679896003902 active site 679896003903 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 679896003904 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 679896003905 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 679896003906 catalytic triad [active] 679896003907 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 679896003908 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 679896003909 homodimer interface [polypeptide binding]; other site 679896003910 Walker A motif; other site 679896003911 ATP binding site [chemical binding]; other site 679896003912 hydroxycobalamin binding site [chemical binding]; other site 679896003913 Walker B motif; other site 679896003914 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 679896003915 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 679896003916 metal ion-dependent adhesion site (MIDAS); other site 679896003917 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 679896003918 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 679896003919 Walker A motif; other site 679896003920 ATP binding site [chemical binding]; other site 679896003921 Walker B motif; other site 679896003922 arginine finger; other site 679896003923 malate:quinone oxidoreductase; Validated; Region: PRK05257 679896003924 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 679896003925 mycothione reductase; Reviewed; Region: PRK07846 679896003926 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 679896003927 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 679896003928 cobyric acid synthase; Provisional; Region: PRK00784 679896003929 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 679896003930 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 679896003931 catalytic triad [active] 679896003932 methionine aminopeptidase; Provisional; Region: PRK12318 679896003933 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 679896003934 active site 679896003935 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 679896003936 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 679896003937 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 679896003938 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 679896003939 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 679896003940 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 679896003941 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 679896003942 active site 679896003943 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 679896003944 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 679896003945 putative substrate binding region [chemical binding]; other site 679896003946 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 679896003947 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 679896003948 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 679896003949 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 679896003950 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 679896003951 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 679896003952 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 679896003953 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 679896003954 ribosome recycling factor; Reviewed; Region: frr; PRK00083 679896003955 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 679896003956 hinge region; other site 679896003957 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 679896003958 putative nucleotide binding site [chemical binding]; other site 679896003959 uridine monophosphate binding site [chemical binding]; other site 679896003960 homohexameric interface [polypeptide binding]; other site 679896003961 elongation factor Ts; Provisional; Region: tsf; PRK09377 679896003962 UBA/TS-N domain; Region: UBA; pfam00627 679896003963 Elongation factor TS; Region: EF_TS; pfam00889 679896003964 Elongation factor TS; Region: EF_TS; pfam00889 679896003965 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 679896003966 rRNA interaction site [nucleotide binding]; other site 679896003967 S8 interaction site; other site 679896003968 putative laminin-1 binding site; other site 679896003969 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 679896003970 Peptidase family M23; Region: Peptidase_M23; pfam01551 679896003971 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 679896003972 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 679896003973 active site 679896003974 DNA binding site [nucleotide binding] 679896003975 Int/Topo IB signature motif; other site 679896003976 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 679896003977 DNA protecting protein DprA; Region: dprA; TIGR00732 679896003978 hypothetical protein; Reviewed; Region: PRK12497 679896003979 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 679896003980 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 679896003981 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 679896003982 Walker A motif; other site 679896003983 ATP binding site [chemical binding]; other site 679896003984 Walker B motif; other site 679896003985 arginine finger; other site 679896003986 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 679896003987 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 679896003988 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 679896003989 RNA/DNA hybrid binding site [nucleotide binding]; other site 679896003990 active site 679896003991 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 679896003992 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 679896003993 Catalytic site [active] 679896003994 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 679896003995 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 679896003996 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 679896003997 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 679896003998 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 679896003999 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 679896004000 RNA binding site [nucleotide binding]; other site 679896004001 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 679896004002 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 679896004003 active site 679896004004 P-loop; other site 679896004005 phosphorylation site [posttranslational modification] 679896004006 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 679896004007 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 679896004008 active site 679896004009 phosphorylation site [posttranslational modification] 679896004010 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 679896004011 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 679896004012 RimM N-terminal domain; Region: RimM; pfam01782 679896004013 PRC-barrel domain; Region: PRC; pfam05239 679896004014 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 679896004015 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 679896004016 signal recognition particle protein; Provisional; Region: PRK10867 679896004017 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 679896004018 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 679896004019 P loop; other site 679896004020 GTP binding site [chemical binding]; other site 679896004021 Signal peptide binding domain; Region: SRP_SPB; pfam02978 679896004022 PII uridylyl-transferase; Provisional; Region: glnD; PRK00227 679896004023 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 679896004024 metal binding triad; other site 679896004025 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 679896004026 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 679896004027 Zn2+ binding site [ion binding]; other site 679896004028 Mg2+ binding site [ion binding]; other site 679896004029 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 679896004030 Nitrogen regulatory protein P-II; Region: P-II; smart00938 679896004031 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 679896004032 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 679896004033 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 679896004034 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 679896004035 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 679896004036 Walker A/P-loop; other site 679896004037 ATP binding site [chemical binding]; other site 679896004038 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 679896004039 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 679896004040 ABC transporter signature motif; other site 679896004041 Walker B; other site 679896004042 D-loop; other site 679896004043 H-loop/switch region; other site 679896004044 Acylphosphatase; Region: Acylphosphatase; cl00551 679896004045 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 679896004046 amino acid carrier protein; Region: agcS; TIGR00835 679896004047 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 679896004048 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 679896004049 DNA binding site [nucleotide binding] 679896004050 catalytic residue [active] 679896004051 H2TH interface [polypeptide binding]; other site 679896004052 putative catalytic residues [active] 679896004053 turnover-facilitating residue; other site 679896004054 intercalation triad [nucleotide binding]; other site 679896004055 8OG recognition residue [nucleotide binding]; other site 679896004056 putative reading head residues; other site 679896004057 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 679896004058 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 679896004059 ribonuclease III; Reviewed; Region: rnc; PRK00102 679896004060 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 679896004061 dimerization interface [polypeptide binding]; other site 679896004062 active site 679896004063 metal binding site [ion binding]; metal-binding site 679896004064 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 679896004065 dsRNA binding site [nucleotide binding]; other site 679896004066 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 679896004067 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 679896004068 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 679896004069 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 679896004070 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 679896004071 hexamer interface [polypeptide binding]; other site 679896004072 ligand binding site [chemical binding]; other site 679896004073 putative active site [active] 679896004074 NAD(P) binding site [chemical binding]; other site 679896004075 glutamate dehydrogenase; Provisional; Region: PRK09414 679896004076 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 679896004077 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 679896004078 NAD(P) binding site [chemical binding]; other site 679896004079 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 679896004080 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 679896004081 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 679896004082 nucleotide binding site/active site [active] 679896004083 HIT family signature motif; other site 679896004084 catalytic residue [active] 679896004085 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 679896004086 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 679896004087 metal binding site [ion binding]; metal-binding site 679896004088 putative dimer interface [polypeptide binding]; other site 679896004089 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 679896004090 homodimer interface [polypeptide binding]; other site 679896004091 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 679896004092 active site pocket [active] 679896004093 Electron transfer DM13; Region: DM13; pfam10517 679896004094 pyruvate kinase; Provisional; Region: PRK06247 679896004095 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 679896004096 domain interfaces; other site 679896004097 active site 679896004098 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 679896004099 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 679896004100 active site 679896004101 ribulose/triose binding site [chemical binding]; other site 679896004102 phosphate binding site [ion binding]; other site 679896004103 substrate (anthranilate) binding pocket [chemical binding]; other site 679896004104 product (indole) binding pocket [chemical binding]; other site 679896004105 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 679896004106 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 679896004107 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 679896004108 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 679896004109 substrate binding site [chemical binding]; other site 679896004110 glutamase interaction surface [polypeptide binding]; other site 679896004111 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 679896004112 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 679896004113 active site 679896004114 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 679896004115 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 679896004116 catalytic residues [active] 679896004117 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 679896004118 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 679896004119 putative active site [active] 679896004120 oxyanion strand; other site 679896004121 catalytic triad [active] 679896004122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 679896004123 Major Facilitator Superfamily; Region: MFS_1; pfam07690 679896004124 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 679896004125 putative active site pocket [active] 679896004126 4-fold oligomerization interface [polypeptide binding]; other site 679896004127 metal binding residues [ion binding]; metal-binding site 679896004128 3-fold/trimer interface [polypeptide binding]; other site 679896004129 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 679896004130 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 679896004131 pyridoxal 5'-phosphate binding site [chemical binding]; other site 679896004132 homodimer interface [polypeptide binding]; other site 679896004133 catalytic residue [active] 679896004134 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 679896004135 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 679896004136 NAD binding site [chemical binding]; other site 679896004137 dimerization interface [polypeptide binding]; other site 679896004138 product binding site; other site 679896004139 substrate binding site [chemical binding]; other site 679896004140 zinc binding site [ion binding]; other site 679896004141 catalytic residues [active] 679896004142 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 679896004143 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 679896004144 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 679896004145 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 679896004146 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 679896004147 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 679896004148 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 679896004149 active site 679896004150 catalytic site [active] 679896004151 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 679896004152 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 679896004153 active site 679896004154 catalytic site [active] 679896004155 substrate binding site [chemical binding]; other site 679896004156 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 679896004157 Dimer interface [polypeptide binding]; other site 679896004158 BRCT sequence motif; other site 679896004159 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 679896004160 synthetase active site [active] 679896004161 NTP binding site [chemical binding]; other site 679896004162 metal binding site [ion binding]; metal-binding site 679896004163 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 679896004164 RNA binding surface [nucleotide binding]; other site 679896004165 Uncharacterized conserved protein [Function unknown]; Region: COG1739 679896004166 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 679896004167 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 679896004168 threonine dehydratase; Validated; Region: PRK08639 679896004169 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 679896004170 tetramer interface [polypeptide binding]; other site 679896004171 pyridoxal 5'-phosphate binding site [chemical binding]; other site 679896004172 catalytic residue [active] 679896004173 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 679896004174 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 679896004175 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 679896004176 active site 679896004177 PHP Thumb interface [polypeptide binding]; other site 679896004178 metal binding site [ion binding]; metal-binding site 679896004179 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 679896004180 generic binding surface I; other site 679896004181 generic binding surface II; other site 679896004182 Predicted permeases [General function prediction only]; Region: RarD; COG2962 679896004183 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 679896004184 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 679896004185 RNA binding surface [nucleotide binding]; other site 679896004186 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 679896004187 active site 679896004188 lipoprotein signal peptidase; Provisional; Region: PRK14764 679896004189 lipoprotein signal peptidase; Provisional; Region: PRK14787 679896004190 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 679896004191 active site 679896004192 homotetramer interface [polypeptide binding]; other site 679896004193 homodimer interface [polypeptide binding]; other site 679896004194 DNA polymerase IV; Provisional; Region: PRK03348 679896004195 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 679896004196 active site 679896004197 DNA binding site [nucleotide binding] 679896004198 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 679896004199 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 679896004200 HIGH motif; other site 679896004201 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 679896004202 active site 679896004203 KMSKS motif; other site 679896004204 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 679896004205 tRNA binding surface [nucleotide binding]; other site 679896004206 anticodon binding site; other site 679896004207 DivIVA protein; Region: DivIVA; pfam05103 679896004208 DivIVA domain; Region: DivI1A_domain; TIGR03544 679896004209 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 679896004210 YGGT family; Region: YGGT; pfam02325 679896004211 Protein of unknown function (DUF552); Region: DUF552; cl00775 679896004212 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 679896004213 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 679896004214 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 679896004215 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 679896004216 nucleotide binding site [chemical binding]; other site 679896004217 SulA interaction site; other site 679896004218 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 679896004219 Cell division protein FtsQ; Region: FtsQ; pfam03799 679896004220 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 679896004221 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 679896004222 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 679896004223 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 679896004224 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 679896004225 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 679896004226 homodimer interface [polypeptide binding]; other site 679896004227 active site 679896004228 cell division protein FtsW; Region: ftsW; TIGR02614 679896004229 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141 679896004230 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 679896004231 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 679896004232 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 679896004233 Mg++ binding site [ion binding]; other site 679896004234 putative catalytic motif [active] 679896004235 putative substrate binding site [chemical binding]; other site 679896004236 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 679896004237 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 679896004238 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 679896004239 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 679896004240 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 679896004241 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 679896004242 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 679896004243 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 679896004244 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 679896004245 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 679896004246 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 679896004247 MraW methylase family; Region: Methyltransf_5; cl17771 679896004248 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 679896004249 cell division protein MraZ; Reviewed; Region: PRK00326 679896004250 MraZ protein; Region: MraZ; pfam02381 679896004251 MraZ protein; Region: MraZ; pfam02381 679896004252 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 679896004253 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 679896004254 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 679896004255 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 679896004256 FAD binding site [chemical binding]; other site 679896004257 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 679896004258 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 679896004259 substrate binding pocket [chemical binding]; other site 679896004260 chain length determination region; other site 679896004261 substrate-Mg2+ binding site; other site 679896004262 catalytic residues [active] 679896004263 aspartate-rich region 1; other site 679896004264 active site lid residues [active] 679896004265 aspartate-rich region 2; other site 679896004266 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 679896004267 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 679896004268 Catalytic domain of Protein Kinases; Region: PKc; cd00180 679896004269 active site 679896004270 ATP binding site [chemical binding]; other site 679896004271 substrate binding site [chemical binding]; other site 679896004272 activation loop (A-loop); other site 679896004273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 679896004274 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 679896004275 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 679896004276 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 679896004277 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 679896004278 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 679896004279 Predicted membrane protein [Function unknown]; Region: COG4763 679896004280 Acyltransferase family; Region: Acyl_transf_3; pfam01757 679896004281 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 679896004282 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 679896004283 putative acyl-acceptor binding pocket; other site 679896004284 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 679896004285 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 679896004286 nucleotide binding site [chemical binding]; other site 679896004287 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 679896004288 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 679896004289 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 679896004290 NlpC/P60 family; Region: NLPC_P60; pfam00877 679896004291 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 679896004292 NlpC/P60 family; Region: NLPC_P60; pfam00877 679896004293 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 679896004294 heme bH binding site [chemical binding]; other site 679896004295 intrachain domain interface; other site 679896004296 heme bL binding site [chemical binding]; other site 679896004297 interchain domain interface [polypeptide binding]; other site 679896004298 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 679896004299 Qo binding site; other site 679896004300 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 679896004301 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 679896004302 iron-sulfur cluster [ion binding]; other site 679896004303 [2Fe-2S] cluster binding site [ion binding]; other site 679896004304 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 679896004305 Cytochrome c; Region: Cytochrom_C; pfam00034 679896004306 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 679896004307 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 679896004308 Subunit I/III interface [polypeptide binding]; other site 679896004309 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 679896004310 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 679896004311 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 679896004312 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 679896004313 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 679896004314 active site 679896004315 dimer interface [polypeptide binding]; other site 679896004316 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 679896004317 Ligand Binding Site [chemical binding]; other site 679896004318 Molecular Tunnel; other site 679896004319 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 679896004320 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 679896004321 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 679896004322 homotrimer interface [polypeptide binding]; other site 679896004323 Walker A motif; other site 679896004324 GTP binding site [chemical binding]; other site 679896004325 Walker B motif; other site 679896004326 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 679896004327 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 679896004328 putative dimer interface [polypeptide binding]; other site 679896004329 active site pocket [active] 679896004330 putative cataytic base [active] 679896004331 cobalamin synthase; Reviewed; Region: cobS; PRK00235 679896004332 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 679896004333 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 679896004334 homodimer interface [polypeptide binding]; other site 679896004335 substrate-cofactor binding pocket; other site 679896004336 catalytic residue [active] 679896004337 multifunctional aminopeptidase A; Provisional; Region: PRK00913 679896004338 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 679896004339 interface (dimer of trimers) [polypeptide binding]; other site 679896004340 Substrate-binding/catalytic site; other site 679896004341 Zn-binding sites [ion binding]; other site 679896004342 glycine dehydrogenase; Provisional; Region: PRK05367 679896004343 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 679896004344 tetramer interface [polypeptide binding]; other site 679896004345 pyridoxal 5'-phosphate binding site [chemical binding]; other site 679896004346 catalytic residue [active] 679896004347 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 679896004348 tetramer interface [polypeptide binding]; other site 679896004349 pyridoxal 5'-phosphate binding site [chemical binding]; other site 679896004350 catalytic residue [active] 679896004351 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 679896004352 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 679896004353 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 679896004354 lipoyl attachment site [posttranslational modification]; other site 679896004355 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 679896004356 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 679896004357 active site 679896004358 lipoate-protein ligase B; Provisional; Region: PRK14345 679896004359 lipoyl synthase; Provisional; Region: PRK05481 679896004360 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 679896004361 FeS/SAM binding site; other site 679896004362 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 679896004363 RDD family; Region: RDD; pfam06271 679896004364 glutamine synthetase, type I; Region: GlnA; TIGR00653 679896004365 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 679896004366 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 679896004367 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 679896004368 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 679896004369 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 679896004370 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 679896004371 DNA binding residues [nucleotide binding] 679896004372 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 679896004373 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 679896004374 DNA methylase; Region: N6_N4_Mtase; pfam01555 679896004375 DNA methylase; Region: N6_N4_Mtase; cl17433 679896004376 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 679896004377 AAA domain; Region: AAA_21; pfam13304 679896004378 Walker A/P-loop; other site 679896004379 ATP binding site [chemical binding]; other site 679896004380 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 679896004381 putative active site [active] 679896004382 putative metal-binding site [ion binding]; other site 679896004383 DNA helicase IV; Provisional; Region: helD; PRK11054 679896004384 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 679896004385 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 679896004386 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 679896004387 HsdM N-terminal domain; Region: HsdM_N; pfam12161 679896004388 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 679896004389 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 679896004390 Walker A/P-loop; other site 679896004391 ATP binding site [chemical binding]; other site 679896004392 Q-loop/lid; other site 679896004393 ABC transporter signature motif; other site 679896004394 Walker B; other site 679896004395 D-loop; other site 679896004396 H-loop/switch region; other site 679896004397 Htaa; Region: HtaA; pfam04213 679896004398 Htaa; Region: HtaA; pfam04213 679896004399 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 679896004400 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 679896004401 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 679896004402 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 679896004403 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 679896004404 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 679896004405 active site 679896004406 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 679896004407 Predicted permease [General function prediction only]; Region: COG2056 679896004408 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 679896004409 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 679896004410 nudix motif; other site 679896004411 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 679896004412 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 679896004413 pyridoxal 5'-phosphate binding site [chemical binding]; other site 679896004414 catalytic residue [active] 679896004415 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 679896004416 active site 679896004417 catalytic site [active] 679896004418 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 679896004419 heme binding pocket [chemical binding]; other site 679896004420 heme ligand [chemical binding]; other site 679896004421 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 679896004422 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 679896004423 metal binding triad; other site 679896004424 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 679896004425 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 679896004426 metal binding triad; other site 679896004427 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 679896004428 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 679896004429 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 679896004430 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 679896004431 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 679896004432 putative active site; other site 679896004433 putative metal binding residues [ion binding]; other site 679896004434 signature motif; other site 679896004435 putative triphosphate binding site [ion binding]; other site 679896004436 CHAD domain; Region: CHAD; pfam05235 679896004437 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 679896004438 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 679896004439 RNB domain; Region: RNB; pfam00773 679896004440 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 679896004441 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 679896004442 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 679896004443 RNA/DNA hybrid binding site [nucleotide binding]; other site 679896004444 active site 679896004445 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 679896004446 catalytic core [active] 679896004447 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 679896004448 Putative zinc ribbon domain; Region: DUF164; pfam02591 679896004449 Uncharacterized conserved protein [Function unknown]; Region: COG0327 679896004450 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 679896004451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 679896004452 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 679896004453 hypothetical protein; Provisional; Region: PRK07908 679896004454 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 679896004455 pyridoxal 5'-phosphate binding site [chemical binding]; other site 679896004456 homodimer interface [polypeptide binding]; other site 679896004457 catalytic residue [active] 679896004458 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 679896004459 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 679896004460 motif II; other site 679896004461 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 679896004462 Low molecular weight phosphatase family; Region: LMWPc; cl00105 679896004463 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 679896004464 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 679896004465 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 679896004466 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 679896004467 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 679896004468 dimer interface [polypeptide binding]; other site 679896004469 TPP-binding site [chemical binding]; other site 679896004470 Phosphopantetheine attachment site; Region: PP-binding; cl09936 679896004471 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 679896004472 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 679896004473 active site 679896004474 motif I; other site 679896004475 motif II; other site 679896004476 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 679896004477 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 679896004478 Beta-lactamase; Region: Beta-lactamase; pfam00144 679896004479 Predicted membrane protein [Function unknown]; Region: COG2860 679896004480 UPF0126 domain; Region: UPF0126; pfam03458 679896004481 UPF0126 domain; Region: UPF0126; pfam03458 679896004482 DNA primase; Validated; Region: dnaG; PRK05667 679896004483 CHC2 zinc finger; Region: zf-CHC2; pfam01807 679896004484 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 679896004485 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 679896004486 active site 679896004487 metal binding site [ion binding]; metal-binding site 679896004488 interdomain interaction site; other site 679896004489 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 679896004490 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 679896004491 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 679896004492 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 679896004493 glutaminase active site [active] 679896004494 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 679896004495 dimer interface [polypeptide binding]; other site 679896004496 active site 679896004497 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 679896004498 dimer interface [polypeptide binding]; other site 679896004499 active site 679896004500 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 679896004501 active site 679896004502 barstar interaction site; other site 679896004503 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 679896004504 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 679896004505 Zn2+ binding site [ion binding]; other site 679896004506 Mg2+ binding site [ion binding]; other site 679896004507 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 679896004508 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 679896004509 putative active site [active] 679896004510 Repair protein; Region: Repair_PSII; pfam04536 679896004511 glycyl-tRNA synthetase; Provisional; Region: PRK04173 679896004512 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 679896004513 motif 1; other site 679896004514 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 679896004515 active site 679896004516 motif 2; other site 679896004517 motif 3; other site 679896004518 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 679896004519 anticodon binding site; other site 679896004520 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 679896004521 putative DNA binding site [nucleotide binding]; other site 679896004522 putative Zn2+ binding site [ion binding]; other site 679896004523 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 679896004524 metal binding site 2 [ion binding]; metal-binding site 679896004525 putative DNA binding helix; other site 679896004526 metal binding site 1 [ion binding]; metal-binding site 679896004527 dimer interface [polypeptide binding]; other site 679896004528 structural Zn2+ binding site [ion binding]; other site 679896004529 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 679896004530 diiron binding motif [ion binding]; other site 679896004531 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 679896004532 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 679896004533 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 679896004534 catalytic residue [active] 679896004535 putative FPP diphosphate binding site; other site 679896004536 putative FPP binding hydrophobic cleft; other site 679896004537 dimer interface [polypeptide binding]; other site 679896004538 putative IPP diphosphate binding site; other site 679896004539 Recombination protein O N terminal; Region: RecO_N; pfam11967 679896004540 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 679896004541 Recombination protein O C terminal; Region: RecO_C; pfam02565 679896004542 GTPase Era; Reviewed; Region: era; PRK00089 679896004543 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 679896004544 G1 box; other site 679896004545 GTP/Mg2+ binding site [chemical binding]; other site 679896004546 Switch I region; other site 679896004547 G2 box; other site 679896004548 Switch II region; other site 679896004549 G3 box; other site 679896004550 G4 box; other site 679896004551 G5 box; other site 679896004552 KH domain; Region: KH_2; pfam07650 679896004553 pyridoxamine kinase; Validated; Region: PRK05756 679896004554 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 679896004555 dimer interface [polypeptide binding]; other site 679896004556 pyridoxal binding site [chemical binding]; other site 679896004557 ATP binding site [chemical binding]; other site 679896004558 Domain of unknown function DUF21; Region: DUF21; pfam01595 679896004559 FOG: CBS domain [General function prediction only]; Region: COG0517 679896004560 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 679896004561 Transporter associated domain; Region: CorC_HlyC; smart01091 679896004562 metal-binding heat shock protein; Provisional; Region: PRK00016 679896004563 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 679896004564 PhoH-like protein; Region: PhoH; pfam02562 679896004565 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 679896004566 RNA methyltransferase, RsmE family; Region: TIGR00046 679896004567 chaperone protein DnaJ; Provisional; Region: PRK14278 679896004568 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 679896004569 HSP70 interaction site [polypeptide binding]; other site 679896004570 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 679896004571 Zn binding sites [ion binding]; other site 679896004572 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 679896004573 dimer interface [polypeptide binding]; other site 679896004574 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 679896004575 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 679896004576 coproporphyrinogen III oxidase; Validated; Region: PRK05628 679896004577 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 679896004578 FeS/SAM binding site; other site 679896004579 HemN C-terminal domain; Region: HemN_C; pfam06969 679896004580 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 679896004581 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 679896004582 acyl-activating enzyme (AAE) consensus motif; other site 679896004583 putative AMP binding site [chemical binding]; other site 679896004584 putative active site [active] 679896004585 putative CoA binding site [chemical binding]; other site 679896004586 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 679896004587 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 679896004588 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 679896004589 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 679896004590 active site 679896004591 Zn binding site [ion binding]; other site 679896004592 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 679896004593 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 679896004594 substrate binding pocket [chemical binding]; other site 679896004595 catalytic triad [active] 679896004596 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 679896004597 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 679896004598 active site 679896004599 metal binding site [ion binding]; metal-binding site 679896004600 nudix motif; other site 679896004601 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 679896004602 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 679896004603 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 679896004604 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 679896004605 active site 679896004606 BCCT family transporter; Region: BCCT; pfam02028 679896004607 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 679896004608 Predicted permeases [General function prediction only]; Region: COG0679 679896004609 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 679896004610 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 679896004611 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 679896004612 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 679896004613 dimer interface [polypeptide binding]; other site 679896004614 conserved gate region; other site 679896004615 putative PBP binding loops; other site 679896004616 ABC-ATPase subunit interface; other site 679896004617 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 679896004618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 679896004619 dimer interface [polypeptide binding]; other site 679896004620 conserved gate region; other site 679896004621 putative PBP binding loops; other site 679896004622 ABC-ATPase subunit interface; other site 679896004623 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 679896004624 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 679896004625 Walker A/P-loop; other site 679896004626 ATP binding site [chemical binding]; other site 679896004627 Q-loop/lid; other site 679896004628 ABC transporter signature motif; other site 679896004629 Walker B; other site 679896004630 D-loop; other site 679896004631 H-loop/switch region; other site 679896004632 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 679896004633 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 679896004634 Walker A/P-loop; other site 679896004635 ATP binding site [chemical binding]; other site 679896004636 Q-loop/lid; other site 679896004637 ABC transporter signature motif; other site 679896004638 Walker B; other site 679896004639 D-loop; other site 679896004640 H-loop/switch region; other site 679896004641 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 679896004642 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 679896004643 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 679896004644 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 679896004645 catalytic residue [active] 679896004646 Sulphur transport; Region: Sulf_transp; pfam04143 679896004647 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 679896004648 CPxP motif; other site 679896004649 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 679896004650 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 679896004651 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 679896004652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 679896004653 Major Facilitator Superfamily; Region: MFS_1; pfam07690 679896004654 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 679896004655 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 679896004656 thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277 679896004657 Walker A/P-loop; other site 679896004658 ATP binding site [chemical binding]; other site 679896004659 Q-loop/lid; other site 679896004660 ABC transporter signature motif; other site 679896004661 Walker B; other site 679896004662 D-loop; other site 679896004663 H-loop/switch region; other site 679896004664 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 679896004665 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 679896004666 Walker A/P-loop; other site 679896004667 ATP binding site [chemical binding]; other site 679896004668 Q-loop/lid; other site 679896004669 ABC transporter signature motif; other site 679896004670 Walker B; other site 679896004671 D-loop; other site 679896004672 H-loop/switch region; other site 679896004673 GTP-binding protein LepA; Provisional; Region: PRK05433 679896004674 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 679896004675 G1 box; other site 679896004676 putative GEF interaction site [polypeptide binding]; other site 679896004677 GTP/Mg2+ binding site [chemical binding]; other site 679896004678 Switch I region; other site 679896004679 G2 box; other site 679896004680 G3 box; other site 679896004681 Switch II region; other site 679896004682 G4 box; other site 679896004683 G5 box; other site 679896004684 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 679896004685 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 679896004686 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 679896004687 PemK-like protein; Region: PemK; pfam02452 679896004688 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 679896004689 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 679896004690 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 679896004691 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 679896004692 hypothetical protein; Validated; Region: PRK05629 679896004693 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 679896004694 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 679896004695 Competence protein; Region: Competence; pfam03772 679896004696 comEA protein; Region: comE; TIGR01259 679896004697 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 679896004698 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 679896004699 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 679896004700 catalytic core [active] 679896004701 Oligomerisation domain; Region: Oligomerisation; pfam02410 679896004702 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 679896004703 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 679896004704 active site 679896004705 (T/H)XGH motif; other site 679896004706 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 679896004707 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 679896004708 putative catalytic cysteine [active] 679896004709 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 679896004710 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 679896004711 putative ligand binding site [chemical binding]; other site 679896004712 putative NAD binding site [chemical binding]; other site 679896004713 catalytic site [active] 679896004714 Protein of unknown function (DUF454); Region: DUF454; cl01063 679896004715 Predicted permease [General function prediction only]; Region: COG2985 679896004716 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 679896004717 TrkA-C domain; Region: TrkA_C; pfam02080 679896004718 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 679896004719 gamma-glutamyl kinase; Provisional; Region: PRK05429 679896004720 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 679896004721 nucleotide binding site [chemical binding]; other site 679896004722 homotetrameric interface [polypeptide binding]; other site 679896004723 putative phosphate binding site [ion binding]; other site 679896004724 putative allosteric binding site; other site 679896004725 PUA domain; Region: PUA; pfam01472 679896004726 GTPase CgtA; Reviewed; Region: obgE; PRK12296 679896004727 GTP1/OBG; Region: GTP1_OBG; pfam01018 679896004728 Obg GTPase; Region: Obg; cd01898 679896004729 G1 box; other site 679896004730 GTP/Mg2+ binding site [chemical binding]; other site 679896004731 Switch I region; other site 679896004732 G2 box; other site 679896004733 G3 box; other site 679896004734 Switch II region; other site 679896004735 G4 box; other site 679896004736 G5 box; other site 679896004737 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 679896004738 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 679896004739 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 679896004740 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 679896004741 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 679896004742 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 679896004743 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 679896004744 homodimer interface [polypeptide binding]; other site 679896004745 oligonucleotide binding site [chemical binding]; other site 679896004746 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 679896004747 active site 679896004748 multimer interface [polypeptide binding]; other site 679896004749 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 679896004750 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 679896004751 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 679896004752 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 679896004753 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 679896004754 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 679896004755 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 679896004756 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 679896004757 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 679896004758 active site 679896004759 HIGH motif; other site 679896004760 nucleotide binding site [chemical binding]; other site 679896004761 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 679896004762 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 679896004763 active site 679896004764 KMSKS motif; other site 679896004765 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 679896004766 tRNA binding surface [nucleotide binding]; other site 679896004767 anticodon binding site; other site 679896004768 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 679896004769 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 679896004770 malate dehydrogenase; Provisional; Region: PRK05442 679896004771 NAD(P) binding site [chemical binding]; other site 679896004772 dimer interface [polypeptide binding]; other site 679896004773 malate binding site [chemical binding]; other site 679896004774 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 679896004775 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 679896004776 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 679896004777 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 679896004778 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 679896004779 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 679896004780 Walker A motif; other site 679896004781 ATP binding site [chemical binding]; other site 679896004782 Walker B motif; other site 679896004783 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 679896004784 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 679896004785 Glutamine amidotransferase class-I; Region: GATase; pfam00117 679896004786 glutamine binding [chemical binding]; other site 679896004787 catalytic triad [active] 679896004788 hypothetical protein; Validated; Region: PRK09070 679896004789 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 679896004790 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 679896004791 Aminotransferase class IV; Region: Aminotran_4; pfam01063 679896004792 substrate-cofactor binding pocket; other site 679896004793 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 679896004794 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 679896004795 oligomer interface [polypeptide binding]; other site 679896004796 active site residues [active] 679896004797 Clp protease; Region: CLP_protease; pfam00574 679896004798 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 679896004799 oligomer interface [polypeptide binding]; other site 679896004800 active site residues [active] 679896004801 trigger factor; Provisional; Region: tig; PRK01490 679896004802 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 679896004803 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 679896004804 Pirin-related protein [General function prediction only]; Region: COG1741 679896004805 Pirin; Region: Pirin; pfam02678 679896004806 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 679896004807 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 679896004808 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 679896004809 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 679896004810 catalytic residues [active] 679896004811 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 679896004812 Mechanosensitive ion channel; Region: MS_channel; pfam00924 679896004813 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 679896004814 apolar tunnel; other site 679896004815 heme binding site [chemical binding]; other site 679896004816 dimerization interface [polypeptide binding]; other site 679896004817 Protein of unknown function, DUF606; Region: DUF606; pfam04657 679896004818 Protein of unknown function, DUF606; Region: DUF606; pfam04657 679896004819 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 679896004820 active site 679896004821 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 679896004822 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 679896004823 Walker A/P-loop; other site 679896004824 ATP binding site [chemical binding]; other site 679896004825 Q-loop/lid; other site 679896004826 ABC transporter signature motif; other site 679896004827 Walker B; other site 679896004828 D-loop; other site 679896004829 H-loop/switch region; other site 679896004830 ABC transporter; Region: ABC_tran_2; pfam12848 679896004831 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 679896004832 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 679896004833 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 679896004834 dimer interface [polypeptide binding]; other site 679896004835 ssDNA binding site [nucleotide binding]; other site 679896004836 tetramer (dimer of dimers) interface [polypeptide binding]; other site 679896004837 YcaO-like family; Region: YcaO; pfam02624 679896004838 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 679896004839 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 679896004840 FMN binding site [chemical binding]; other site 679896004841 dimer interface [polypeptide binding]; other site 679896004842 Nitroreductase family; Region: Nitroreductase; pfam00881 679896004843 dimer interface [polypeptide binding]; other site 679896004844 SpaB C-terminal domain; Region: SpaB_C; pfam14028 679896004845 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 679896004846 YcaO-like family; Region: YcaO; pfam02624 679896004847 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 679896004848 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 679896004849 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 679896004850 Walker A/P-loop; other site 679896004851 ATP binding site [chemical binding]; other site 679896004852 Q-loop/lid; other site 679896004853 ABC transporter signature motif; other site 679896004854 Walker B; other site 679896004855 D-loop; other site 679896004856 H-loop/switch region; other site 679896004857 Copper resistance protein D; Region: CopD; pfam05425 679896004858 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 679896004859 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 679896004860 Carbon starvation protein CstA; Region: CstA; pfam02554 679896004861 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 679896004862 Protein of unknown function (DUF466); Region: DUF466; pfam04328 679896004863 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 679896004864 active site 679896004865 catalytic triad [active] 679896004866 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 679896004867 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 679896004868 NADP binding site [chemical binding]; other site 679896004869 dimer interface [polypeptide binding]; other site 679896004870 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 679896004871 classical (c) SDRs; Region: SDR_c; cd05233 679896004872 NAD(P) binding site [chemical binding]; other site 679896004873 active site 679896004874 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 679896004875 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 679896004876 catalytic site [active] 679896004877 putative active site [active] 679896004878 putative substrate binding site [chemical binding]; other site 679896004879 dimer interface [polypeptide binding]; other site 679896004880 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 679896004881 N-acetylneuraminate lyase; Provisional; Region: PRK04147 679896004882 inhibitor site; inhibition site 679896004883 active site 679896004884 dimer interface [polypeptide binding]; other site 679896004885 catalytic residue [active] 679896004886 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 679896004887 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 679896004888 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 679896004889 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 679896004890 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 679896004891 Prostaglandin dehydrogenases; Region: PGDH; cd05288 679896004892 NAD(P) binding site [chemical binding]; other site 679896004893 substrate binding site [chemical binding]; other site 679896004894 dimer interface [polypeptide binding]; other site 679896004895 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 679896004896 Isochorismatase family; Region: Isochorismatase; pfam00857 679896004897 catalytic triad [active] 679896004898 metal binding site [ion binding]; metal-binding site 679896004899 conserved cis-peptide bond; other site 679896004900 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 679896004901 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 679896004902 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 679896004903 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 679896004904 catalytic triad [active] 679896004905 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 679896004906 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 679896004907 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 679896004908 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 679896004909 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 679896004910 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 679896004911 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 679896004912 phosphate binding site [ion binding]; other site 679896004913 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 679896004914 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 679896004915 active site 2 [active] 679896004916 active site 1 [active] 679896004917 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 679896004918 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 679896004919 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 679896004920 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 679896004921 putative NAD(P) binding site [chemical binding]; other site 679896004922 active site 679896004923 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 679896004924 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 679896004925 active site 679896004926 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 679896004927 Histidine kinase; Region: HisKA_3; pfam07730 679896004928 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 679896004929 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 679896004930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 679896004931 active site 679896004932 phosphorylation site [posttranslational modification] 679896004933 intermolecular recognition site; other site 679896004934 dimerization interface [polypeptide binding]; other site 679896004935 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 679896004936 DNA binding residues [nucleotide binding] 679896004937 dimerization interface [polypeptide binding]; other site 679896004938 Protein of unknown function (DUF418); Region: DUF418; pfam04235 679896004939 CAAX protease self-immunity; Region: Abi; pfam02517 679896004940 Glucitol operon activator protein (GutM); Region: GutM; cl01890 679896004941 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 679896004942 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 679896004943 active site 679896004944 dimerization interface [polypeptide binding]; other site 679896004945 ribonuclease PH; Reviewed; Region: rph; PRK00173 679896004946 Ribonuclease PH; Region: RNase_PH_bact; cd11362 679896004947 hexamer interface [polypeptide binding]; other site 679896004948 active site 679896004949 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 679896004950 glutamate racemase; Provisional; Region: PRK00865 679896004951 Rhomboid family; Region: Rhomboid; pfam01694 679896004952 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 679896004953 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 679896004954 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 679896004955 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 679896004956 active site 679896004957 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 679896004958 DEAD/DEAH box helicase; Region: DEAD; pfam00270 679896004959 ATP binding site [chemical binding]; other site 679896004960 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 679896004961 putative Mg++ binding site [ion binding]; other site 679896004962 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 679896004963 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 679896004964 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 679896004965 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 679896004966 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 679896004967 phosphoserine phosphatase SerB; Region: serB; TIGR00338 679896004968 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 679896004969 motif II; other site 679896004970 Winged helix-turn helix; Region: HTH_29; pfam13551 679896004971 Helix-turn-helix domain; Region: HTH_28; pfam13518 679896004972 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 679896004973 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 679896004974 D-pathway; other site 679896004975 Putative ubiquinol binding site [chemical binding]; other site 679896004976 Low-spin heme (heme b) binding site [chemical binding]; other site 679896004977 Putative water exit pathway; other site 679896004978 Binuclear center (heme o3/CuB) [ion binding]; other site 679896004979 K-pathway; other site 679896004980 Putative proton exit pathway; other site 679896004981 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 679896004982 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 679896004983 dimer interface [polypeptide binding]; other site 679896004984 putative radical transfer pathway; other site 679896004985 diiron center [ion binding]; other site 679896004986 tyrosyl radical; other site 679896004987 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 679896004988 Ferritin-like domain; Region: Ferritin; pfam00210 679896004989 ferroxidase diiron center [ion binding]; other site 679896004990 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 679896004991 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 679896004992 Class I ribonucleotide reductase; Region: RNR_I; cd01679 679896004993 active site 679896004994 dimer interface [polypeptide binding]; other site 679896004995 catalytic residues [active] 679896004996 effector binding site; other site 679896004997 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 679896004998 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 679896004999 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 679896005000 catalytic residues [active] 679896005001 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 679896005002 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 679896005003 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 679896005004 homodimer interface [polypeptide binding]; other site 679896005005 NAD binding pocket [chemical binding]; other site 679896005006 ATP binding pocket [chemical binding]; other site 679896005007 Mg binding site [ion binding]; other site 679896005008 active-site loop [active] 679896005009 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 679896005010 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 679896005011 dimerization interface [polypeptide binding]; other site 679896005012 putative DNA binding site [nucleotide binding]; other site 679896005013 putative Zn2+ binding site [ion binding]; other site 679896005014 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 679896005015 Thioredoxin; Region: Thioredoxin_4; cl17273 679896005016 Predicted membrane protein [Function unknown]; Region: COG2259 679896005017 phosphoglucomutase; Validated; Region: PRK07564 679896005018 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 679896005019 active site 679896005020 substrate binding site [chemical binding]; other site 679896005021 metal binding site [ion binding]; metal-binding site 679896005022 camphor resistance protein CrcB; Provisional; Region: ccrB; PRK00134 679896005023 CrcB-like protein; Region: CRCB; pfam02537 679896005024 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 679896005025 FtsX-like permease family; Region: FtsX; pfam02687 679896005026 FtsX-like permease family; Region: FtsX; pfam02687 679896005027 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 679896005028 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 679896005029 Walker A/P-loop; other site 679896005030 ATP binding site [chemical binding]; other site 679896005031 Q-loop/lid; other site 679896005032 ABC transporter signature motif; other site 679896005033 Walker B; other site 679896005034 D-loop; other site 679896005035 H-loop/switch region; other site 679896005036 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 679896005037 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 679896005038 hinge; other site 679896005039 active site 679896005040 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 679896005041 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 679896005042 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 679896005043 DNA binding residues [nucleotide binding] 679896005044 dimerization interface [polypeptide binding]; other site 679896005045 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 679896005046 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 679896005047 dimer interface [polypeptide binding]; other site 679896005048 pyridoxal 5'-phosphate binding site [chemical binding]; other site 679896005049 catalytic residue [active] 679896005050 serine O-acetyltransferase; Region: cysE; TIGR01172 679896005051 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 679896005052 trimer interface [polypeptide binding]; other site 679896005053 active site 679896005054 substrate binding site [chemical binding]; other site 679896005055 CoA binding site [chemical binding]; other site 679896005056 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 679896005057 Coenzyme A binding pocket [chemical binding]; other site 679896005058 Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171 679896005059 putative active site [active] 679896005060 metal binding site [ion binding]; metal-binding site 679896005061 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 679896005062 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 679896005063 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 679896005064 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 679896005065 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 679896005066 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 679896005067 Walker A/P-loop; other site 679896005068 ATP binding site [chemical binding]; other site 679896005069 Q-loop/lid; other site 679896005070 ABC transporter signature motif; other site 679896005071 Walker B; other site 679896005072 D-loop; other site 679896005073 H-loop/switch region; other site 679896005074 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 679896005075 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 679896005076 Walker A/P-loop; other site 679896005077 ATP binding site [chemical binding]; other site 679896005078 Q-loop/lid; other site 679896005079 ABC transporter signature motif; other site 679896005080 Walker B; other site 679896005081 D-loop; other site 679896005082 H-loop/switch region; other site 679896005083 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 679896005084 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 679896005085 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 679896005086 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 679896005087 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 679896005088 FMN binding site [chemical binding]; other site 679896005089 active site 679896005090 catalytic residues [active] 679896005091 substrate binding site [chemical binding]; other site 679896005092 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 679896005093 PhoU domain; Region: PhoU; pfam01895 679896005094 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 679896005095 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 679896005096 Walker A/P-loop; other site 679896005097 ATP binding site [chemical binding]; other site 679896005098 Q-loop/lid; other site 679896005099 ABC transporter signature motif; other site 679896005100 Walker B; other site 679896005101 D-loop; other site 679896005102 H-loop/switch region; other site 679896005103 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 679896005104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 679896005105 dimer interface [polypeptide binding]; other site 679896005106 conserved gate region; other site 679896005107 putative PBP binding loops; other site 679896005108 ABC-ATPase subunit interface; other site 679896005109 PBP superfamily domain; Region: PBP_like_2; cl17296 679896005110 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 679896005111 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 679896005112 Coenzyme A binding pocket [chemical binding]; other site 679896005113 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 679896005114 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 679896005115 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 679896005116 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 679896005117 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 679896005118 heme-binding site [chemical binding]; other site 679896005119 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 679896005120 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 679896005121 pyridoxal 5'-phosphate binding site [chemical binding]; other site 679896005122 catalytic residue [active] 679896005123 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 679896005124 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 679896005125 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 679896005126 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 679896005127 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 679896005128 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 679896005129 dimerization interface [polypeptide binding]; other site 679896005130 putative ATP binding site [chemical binding]; other site 679896005131 amidophosphoribosyltransferase; Provisional; Region: PRK07847 679896005132 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 679896005133 active site 679896005134 tetramer interface [polypeptide binding]; other site 679896005135 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 679896005136 active site 679896005137 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 679896005138 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 679896005139 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 679896005140 dimer interface [polypeptide binding]; other site 679896005141 putative radical transfer pathway; other site 679896005142 diiron center [ion binding]; other site 679896005143 tyrosyl radical; other site 679896005144 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 679896005145 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 679896005146 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 679896005147 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 679896005148 dimerization interface [polypeptide binding]; other site 679896005149 ATP binding site [chemical binding]; other site 679896005150 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 679896005151 dimerization interface [polypeptide binding]; other site 679896005152 ATP binding site [chemical binding]; other site 679896005153 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 679896005154 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 679896005155 putative active site [active] 679896005156 catalytic triad [active] 679896005157 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 679896005158 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 679896005159 catalytic residues [active] 679896005160 dimer interface [polypeptide binding]; other site 679896005161 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 679896005162 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 679896005163 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 679896005164 ATP binding site [chemical binding]; other site 679896005165 active site 679896005166 substrate binding site [chemical binding]; other site 679896005167 adenylosuccinate lyase; Region: purB; TIGR00928 679896005168 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 679896005169 tetramer interface [polypeptide binding]; other site 679896005170 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 679896005171 TrkA-N domain; Region: TrkA_N; pfam02254 679896005172 TrkA-C domain; Region: TrkA_C; pfam02080 679896005173 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 679896005174 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 679896005175 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 679896005176 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 679896005177 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 679896005178 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 679896005179 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 679896005180 nucleotide binding site/active site [active] 679896005181 HIT family signature motif; other site 679896005182 catalytic residue [active] 679896005183 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 679896005184 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 679896005185 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 679896005186 dimerization interface [polypeptide binding]; other site 679896005187 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 679896005188 dimer interface [polypeptide binding]; other site 679896005189 phosphorylation site [posttranslational modification] 679896005190 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 679896005191 ATP binding site [chemical binding]; other site 679896005192 Mg2+ binding site [ion binding]; other site 679896005193 G-X-G motif; other site 679896005194 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 679896005195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 679896005196 active site 679896005197 phosphorylation site [posttranslational modification] 679896005198 intermolecular recognition site; other site 679896005199 dimerization interface [polypeptide binding]; other site 679896005200 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 679896005201 DNA binding site [nucleotide binding] 679896005202 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 679896005203 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 679896005204 Predicted esterase [General function prediction only]; Region: COG0627 679896005205 S-formylglutathione hydrolase; Region: PLN02442 679896005206 xanthine permease; Region: pbuX; TIGR03173 679896005207 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 679896005208 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 679896005209 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 679896005210 putative active site [active] 679896005211 pyruvate dehydrogenase; Provisional; Region: PRK06546 679896005212 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 679896005213 PYR/PP interface [polypeptide binding]; other site 679896005214 tetramer interface [polypeptide binding]; other site 679896005215 dimer interface [polypeptide binding]; other site 679896005216 TPP binding site [chemical binding]; other site 679896005217 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 679896005218 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 679896005219 TPP-binding site [chemical binding]; other site 679896005220 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 679896005221 Uncharacterized conserved protein [Function unknown]; Region: COG3610 679896005222 Uncharacterized conserved protein [Function unknown]; Region: COG2966 679896005223 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 679896005224 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 679896005225 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 679896005226 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 679896005227 active site 679896005228 homotetramer interface [polypeptide binding]; other site 679896005229 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 679896005230 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 679896005231 Transcriptional regulators [Transcription]; Region: PurR; COG1609 679896005232 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 679896005233 DNA binding site [nucleotide binding] 679896005234 domain linker motif; other site 679896005235 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 679896005236 putative dimerization interface [polypeptide binding]; other site 679896005237 putative ligand binding site [chemical binding]; other site 679896005238 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 679896005239 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 679896005240 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 679896005241 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 679896005242 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 679896005243 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 679896005244 active site 679896005245 HIGH motif; other site 679896005246 nucleotide binding site [chemical binding]; other site 679896005247 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 679896005248 KMSKS motif; other site 679896005249 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 679896005250 tRNA binding surface [nucleotide binding]; other site 679896005251 anticodon binding site; other site 679896005252 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 679896005253 homotrimer interaction site [polypeptide binding]; other site 679896005254 zinc binding site [ion binding]; other site 679896005255 CDP-binding sites; other site 679896005256 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 679896005257 substrate binding site; other site 679896005258 dimer interface; other site 679896005259 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 679896005260 DNA repair protein RadA; Provisional; Region: PRK11823 679896005261 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 679896005262 Walker A motif; other site 679896005263 ATP binding site [chemical binding]; other site 679896005264 Walker B motif; other site 679896005265 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 679896005266 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 679896005267 active site clefts [active] 679896005268 zinc binding site [ion binding]; other site 679896005269 dimer interface [polypeptide binding]; other site 679896005270 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 679896005271 endonuclease III; Region: ENDO3c; smart00478 679896005272 minor groove reading motif; other site 679896005273 helix-hairpin-helix signature motif; other site 679896005274 substrate binding pocket [chemical binding]; other site 679896005275 active site 679896005276 Uncharacterized conserved protein [Function unknown]; Region: COG2966 679896005277 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 679896005278 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 679896005279 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 679896005280 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 679896005281 Clp amino terminal domain; Region: Clp_N; pfam02861 679896005282 Clp amino terminal domain; Region: Clp_N; pfam02861 679896005283 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 679896005284 Walker A motif; other site 679896005285 ATP binding site [chemical binding]; other site 679896005286 Walker B motif; other site 679896005287 arginine finger; other site 679896005288 UvrB/uvrC motif; Region: UVR; pfam02151 679896005289 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 679896005290 Walker A motif; other site 679896005291 ATP binding site [chemical binding]; other site 679896005292 Walker B motif; other site 679896005293 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 679896005294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 679896005295 putative substrate translocation pore; other site 679896005296 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 679896005297 active site 679896005298 tetramer interface [polypeptide binding]; other site 679896005299 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 679896005300 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 679896005301 CAAX protease self-immunity; Region: Abi; pfam02517 679896005302 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 679896005303 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 679896005304 dimer interface [polypeptide binding]; other site 679896005305 putative anticodon binding site; other site 679896005306 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 679896005307 motif 1; other site 679896005308 dimer interface [polypeptide binding]; other site 679896005309 active site 679896005310 motif 2; other site 679896005311 motif 3; other site 679896005312 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 679896005313 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 679896005314 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 679896005315 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 679896005316 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 679896005317 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 679896005318 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 679896005319 NAD(P) binding site [chemical binding]; other site 679896005320 catalytic residues [active] 679896005321 BCCT family transporter; Region: BCCT; cl00569 679896005322 choline dehydrogenase; Validated; Region: PRK02106 679896005323 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 679896005324 pantoate--beta-alanine ligase; Region: panC; TIGR00018 679896005325 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 679896005326 active site 679896005327 nucleotide binding site [chemical binding]; other site 679896005328 HIGH motif; other site 679896005329 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 679896005330 KMSKS motif; other site 679896005331 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 679896005332 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 679896005333 catalytic center binding site [active] 679896005334 ATP binding site [chemical binding]; other site 679896005335 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 679896005336 homooctamer interface [polypeptide binding]; other site 679896005337 active site 679896005338 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 679896005339 dihydropteroate synthase; Region: DHPS; TIGR01496 679896005340 substrate binding pocket [chemical binding]; other site 679896005341 dimer interface [polypeptide binding]; other site 679896005342 inhibitor binding site; inhibition site 679896005343 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 679896005344 GTP cyclohydrolase I; Provisional; Region: PLN03044 679896005345 homodecamer interface [polypeptide binding]; other site 679896005346 active site 679896005347 putative catalytic site residues [active] 679896005348 zinc binding site [ion binding]; other site 679896005349 GTP-CH-I/GFRP interaction surface; other site 679896005350 FtsH Extracellular; Region: FtsH_ext; pfam06480 679896005351 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 679896005352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 679896005353 Walker A motif; other site 679896005354 ATP binding site [chemical binding]; other site 679896005355 Walker B motif; other site 679896005356 arginine finger; other site 679896005357 Peptidase family M41; Region: Peptidase_M41; pfam01434 679896005358 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 679896005359 active site 679896005360 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 679896005361 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 679896005362 Ligand Binding Site [chemical binding]; other site 679896005363 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 679896005364 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 679896005365 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 679896005366 dimer interface [polypeptide binding]; other site 679896005367 substrate binding site [chemical binding]; other site 679896005368 metal binding sites [ion binding]; metal-binding site 679896005369 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 679896005370 active site residue [active] 679896005371 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 679896005372 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 679896005373 Secretory lipase; Region: LIP; pfam03583 679896005374 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 679896005375 MarR family; Region: MarR_2; pfam12802 679896005376 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 679896005377 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 679896005378 acyl-activating enzyme (AAE) consensus motif; other site 679896005379 AMP binding site [chemical binding]; other site 679896005380 active site 679896005381 CoA binding site [chemical binding]; other site 679896005382 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 679896005383 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 679896005384 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 679896005385 putative trimer interface [polypeptide binding]; other site 679896005386 putative CoA binding site [chemical binding]; other site 679896005387 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 679896005388 putative trimer interface [polypeptide binding]; other site 679896005389 putative CoA binding site [chemical binding]; other site 679896005390 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 679896005391 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 679896005392 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 679896005393 ring oligomerisation interface [polypeptide binding]; other site 679896005394 ATP/Mg binding site [chemical binding]; other site 679896005395 stacking interactions; other site 679896005396 hinge regions; other site 679896005397 hypothetical protein; Provisional; Region: PRK07907 679896005398 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 679896005399 active site 679896005400 metal binding site [ion binding]; metal-binding site 679896005401 dimer interface [polypeptide binding]; other site 679896005402 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 679896005403 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 679896005404 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 679896005405 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 679896005406 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 679896005407 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 679896005408 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 679896005409 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 679896005410 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 679896005411 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948 679896005412 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12592 679896005413 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 679896005414 carboxylate-amine ligase; Provisional; Region: PRK13517 679896005415 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 679896005416 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 679896005417 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 679896005418 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 679896005419 active site 679896005420 catalytic residues [active] 679896005421 metal binding site [ion binding]; metal-binding site 679896005422 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 679896005423 Coenzyme A binding pocket [chemical binding]; other site 679896005424 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 679896005425 putative catalytic site [active] 679896005426 putative phosphate binding site [ion binding]; other site 679896005427 active site 679896005428 metal binding site A [ion binding]; metal-binding site 679896005429 DNA binding site [nucleotide binding] 679896005430 putative AP binding site [nucleotide binding]; other site 679896005431 putative metal binding site B [ion binding]; other site 679896005432 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 679896005433 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 679896005434 putative active site [active] 679896005435 catalytic site [active] 679896005436 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 679896005437 putative active site [active] 679896005438 catalytic site [active] 679896005439 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 679896005440 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 679896005441 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 679896005442 Walker A/P-loop; other site 679896005443 ATP binding site [chemical binding]; other site 679896005444 Q-loop/lid; other site 679896005445 ABC transporter signature motif; other site 679896005446 Walker B; other site 679896005447 D-loop; other site 679896005448 H-loop/switch region; other site 679896005449 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 679896005450 nudix motif; other site 679896005451 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 679896005452 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 679896005453 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 679896005454 substrate binding pocket [chemical binding]; other site 679896005455 membrane-bound complex binding site; other site 679896005456 hinge residues; other site 679896005457 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 679896005458 Catalytic domain of Protein Kinases; Region: PKc; cd00180 679896005459 active site 679896005460 ATP binding site [chemical binding]; other site 679896005461 substrate binding site [chemical binding]; other site 679896005462 activation loop (A-loop); other site 679896005463 propionate/acetate kinase; Provisional; Region: PRK12379 679896005464 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 679896005465 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 679896005466 ferredoxin-NADP+ reductase; Region: PLN02852 679896005467 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 679896005468 Coenzyme A binding pocket [chemical binding]; other site 679896005469 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 679896005470 active site 679896005471 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 679896005472 ATP-grasp domain; Region: ATP-grasp_4; cl17255 679896005473 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 679896005474 active site 679896005475 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 679896005476 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 679896005477 catalytic residues [active] 679896005478 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 679896005479 ResB-like family; Region: ResB; pfam05140 679896005480 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 679896005481 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 679896005482 TPR motif; other site 679896005483 TPR repeat; Region: TPR_11; pfam13414 679896005484 binding surface 679896005485 Cytochrome c552; Region: Cytochrom_C552; pfam02335 679896005486 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 679896005487 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 679896005488 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 679896005489 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 679896005490 GDP-binding site [chemical binding]; other site 679896005491 ACT binding site; other site 679896005492 IMP binding site; other site 679896005493 Predicted membrane protein [Function unknown]; Region: COG4129 679896005494 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 679896005495 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 679896005496 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 679896005497 Walker A/P-loop; other site 679896005498 ATP binding site [chemical binding]; other site 679896005499 Q-loop/lid; other site 679896005500 ABC transporter signature motif; other site 679896005501 Walker B; other site 679896005502 D-loop; other site 679896005503 H-loop/switch region; other site 679896005504 Predicted transcriptional regulators [Transcription]; Region: COG1695 679896005505 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 679896005506 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 679896005507 Cna protein B-type domain; Region: Cna_B; pfam05738 679896005508 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 679896005509 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 679896005510 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 679896005511 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 679896005512 active site 679896005513 intersubunit interface [polypeptide binding]; other site 679896005514 zinc binding site [ion binding]; other site 679896005515 Na+ binding site [ion binding]; other site 679896005516 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 679896005517 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 679896005518 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 679896005519 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 679896005520 active site 679896005521 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 679896005522 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 679896005523 active site residue [active] 679896005524 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 679896005525 active site residue [active] 679896005526 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 679896005527 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 679896005528 Gram positive anchor; Region: Gram_pos_anchor; cl15427 679896005529 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 679896005530 active site 679896005531 catalytic site [active] 679896005532 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 679896005533 Cna protein B-type domain; Region: Cna_B; pfam05738 679896005534 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 679896005535 active site 679896005536 catalytic site [active] 679896005537 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 679896005538 Clp amino terminal domain; Region: Clp_N; pfam02861 679896005539 Clp amino terminal domain; Region: Clp_N; pfam02861 679896005540 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 679896005541 Walker A motif; other site 679896005542 ATP binding site [chemical binding]; other site 679896005543 Walker B motif; other site 679896005544 arginine finger; other site 679896005545 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 679896005546 Walker A motif; other site 679896005547 ATP binding site [chemical binding]; other site 679896005548 Walker B motif; other site 679896005549 arginine finger; other site 679896005550 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 679896005551 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 679896005552 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 679896005553 Walker A/P-loop; other site 679896005554 ATP binding site [chemical binding]; other site 679896005555 Q-loop/lid; other site 679896005556 ABC transporter signature motif; other site 679896005557 Walker B; other site 679896005558 D-loop; other site 679896005559 H-loop/switch region; other site 679896005560 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 679896005561 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 679896005562 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 679896005563 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 679896005564 FAD binding pocket [chemical binding]; other site 679896005565 conserved FAD binding motif [chemical binding]; other site 679896005566 phosphate binding motif [ion binding]; other site 679896005567 beta-alpha-beta structure motif; other site 679896005568 NAD binding pocket [chemical binding]; other site 679896005569 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 679896005570 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 679896005571 FtsX-like permease family; Region: FtsX; pfam02687 679896005572 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 679896005573 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 679896005574 Walker A/P-loop; other site 679896005575 ATP binding site [chemical binding]; other site 679896005576 Q-loop/lid; other site 679896005577 ABC transporter signature motif; other site 679896005578 Walker B; other site 679896005579 D-loop; other site 679896005580 H-loop/switch region; other site 679896005581 HlyD family secretion protein; Region: HlyD_3; pfam13437 679896005582 Predicted amidohydrolase [General function prediction only]; Region: COG0388 679896005583 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 679896005584 putative active site [active] 679896005585 catalytic triad [active] 679896005586 putative dimer interface [polypeptide binding]; other site 679896005587 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 679896005588 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 679896005589 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 679896005590 NAD binding site [chemical binding]; other site 679896005591 substrate binding site [chemical binding]; other site 679896005592 catalytic Zn binding site [ion binding]; other site 679896005593 tetramer interface [polypeptide binding]; other site 679896005594 structural Zn binding site [ion binding]; other site 679896005595 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 679896005596 active site 679896005597 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 679896005598 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 679896005599 DNA binding residues [nucleotide binding] 679896005600 chaperone protein DnaJ; Provisional; Region: PRK14279 679896005601 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 679896005602 HSP70 interaction site [polypeptide binding]; other site 679896005603 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 679896005604 Zn binding sites [ion binding]; other site 679896005605 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 679896005606 dimer interface [polypeptide binding]; other site 679896005607 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 679896005608 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 679896005609 dimer interface [polypeptide binding]; other site 679896005610 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 679896005611 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 679896005612 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 679896005613 nucleotide binding site [chemical binding]; other site 679896005614 NEF interaction site [polypeptide binding]; other site 679896005615 SBD interface [polypeptide binding]; other site 679896005616 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 679896005617 active site 679896005618 catalytic site [active] 679896005619 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 679896005620 Domain of unknown function DUF20; Region: UPF0118; pfam01594 679896005621 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 679896005622 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 679896005623 Walker A/P-loop; other site 679896005624 ATP binding site [chemical binding]; other site 679896005625 Q-loop/lid; other site 679896005626 ABC transporter signature motif; other site 679896005627 Walker B; other site 679896005628 D-loop; other site 679896005629 H-loop/switch region; other site 679896005630 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 679896005631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 679896005632 putative PBP binding loops; other site 679896005633 dimer interface [polypeptide binding]; other site 679896005634 ABC-ATPase subunit interface; other site 679896005635 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 679896005636 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 679896005637 Walker A/P-loop; other site 679896005638 ATP binding site [chemical binding]; other site 679896005639 Q-loop/lid; other site 679896005640 ABC transporter signature motif; other site 679896005641 Walker B; other site 679896005642 D-loop; other site 679896005643 H-loop/switch region; other site 679896005644 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 679896005645 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 679896005646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 679896005647 dimer interface [polypeptide binding]; other site 679896005648 conserved gate region; other site 679896005649 putative PBP binding loops; other site 679896005650 ABC-ATPase subunit interface; other site 679896005651 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 679896005652 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 679896005653 adrenodoxin reductase; Provisional; Region: PTZ00188 679896005654 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 679896005655 4Fe-4S binding domain; Region: Fer4; cl02805 679896005656 4Fe-4S binding domain; Region: Fer4; pfam00037 679896005657 Cysteine-rich domain; Region: CCG; pfam02754 679896005658 Cysteine-rich domain; Region: CCG; pfam02754 679896005659 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 679896005660 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 679896005661 dimerization interface [polypeptide binding]; other site 679896005662 putative DNA binding site [nucleotide binding]; other site 679896005663 putative Zn2+ binding site [ion binding]; other site 679896005664 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 679896005665 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 679896005666 Walker A/P-loop; other site 679896005667 ATP binding site [chemical binding]; other site 679896005668 Q-loop/lid; other site 679896005669 ABC transporter signature motif; other site 679896005670 Walker B; other site 679896005671 D-loop; other site 679896005672 H-loop/switch region; other site 679896005673 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 679896005674 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 679896005675 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 679896005676 putative PBP binding regions; other site 679896005677 ABC-ATPase subunit interface; other site 679896005678 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 679896005679 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 679896005680 intersubunit interface [polypeptide binding]; other site 679896005681 UreD urease accessory protein; Region: UreD; cl00530 679896005682 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 679896005683 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 679896005684 UreF; Region: UreF; pfam01730 679896005685 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 679896005686 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 679896005687 dimer interface [polypeptide binding]; other site 679896005688 catalytic residues [active] 679896005689 urease subunit alpha; Reviewed; Region: ureC; PRK13207 679896005690 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 679896005691 subunit interactions [polypeptide binding]; other site 679896005692 active site 679896005693 flap region; other site 679896005694 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 679896005695 gamma-beta subunit interface [polypeptide binding]; other site 679896005696 alpha-beta subunit interface [polypeptide binding]; other site 679896005697 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 679896005698 alpha-gamma subunit interface [polypeptide binding]; other site 679896005699 beta-gamma subunit interface [polypeptide binding]; other site 679896005700 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 679896005701 EamA-like transporter family; Region: EamA; pfam00892 679896005702 EamA-like transporter family; Region: EamA; pfam00892 679896005703 aminotransferase AlaT; Validated; Region: PRK09265 679896005704 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 679896005705 pyridoxal 5'-phosphate binding site [chemical binding]; other site 679896005706 homodimer interface [polypeptide binding]; other site 679896005707 catalytic residue [active] 679896005708 YibE/F-like protein; Region: YibE_F; pfam07907 679896005709 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 679896005710 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 679896005711 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 679896005712 dimer interface [polypeptide binding]; other site 679896005713 putative anticodon binding site; other site 679896005714 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 679896005715 motif 1; other site 679896005716 dimer interface [polypeptide binding]; other site 679896005717 active site 679896005718 motif 2; other site 679896005719 motif 3; other site 679896005720 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 679896005721 Protein of unknown function (DUF998); Region: DUF998; pfam06197 679896005722 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 679896005723 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 679896005724 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 679896005725 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 679896005726 trimer interface [polypeptide binding]; other site 679896005727 active site 679896005728 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 679896005729 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 679896005730 NAD(P) binding site [chemical binding]; other site 679896005731 catalytic residues [active] 679896005732 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 679896005733 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 679896005734 VanW like protein; Region: VanW; pfam04294 679896005735 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 679896005736 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 679896005737 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 679896005738 Acyltransferase family; Region: Acyl_transf_3; pfam01757 679896005739 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 679896005740 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 679896005741 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 679896005742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 679896005743 S-adenosylmethionine binding site [chemical binding]; other site 679896005744 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 679896005745 active site 679896005746 substrate-binding site [chemical binding]; other site 679896005747 metal-binding site [ion binding] 679896005748 GTP binding site [chemical binding]; other site 679896005749 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 679896005750 S-adenosylmethionine binding site [chemical binding]; other site 679896005751 LabA_like proteins; Region: LabA_like; cd06167 679896005752 putative metal binding site [ion binding]; other site 679896005753 MMPL family; Region: MMPL; pfam03176 679896005754 MMPL family; Region: MMPL; pfam03176 679896005755 Predicted integral membrane protein [Function unknown]; Region: COG0392 679896005756 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 679896005757 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 679896005758 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 679896005759 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 679896005760 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 679896005761 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 679896005762 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 679896005763 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 679896005764 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 679896005765 active site 679896005766 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 679896005767 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 679896005768 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 679896005769 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 679896005770 acyl-activating enzyme (AAE) consensus motif; other site 679896005771 active site 679896005772 Cutinase; Region: Cutinase; pfam01083 679896005773 Putative esterase; Region: Esterase; pfam00756 679896005774 S-formylglutathione hydrolase; Region: PLN02442 679896005775 LGFP repeat; Region: LGFP; pfam08310 679896005776 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 679896005777 LGFP repeat; Region: LGFP; pfam08310 679896005778 LGFP repeat; Region: LGFP; pfam08310 679896005779 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 679896005780 Predicted esterase [General function prediction only]; Region: COG0627 679896005781 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 679896005782 UbiA prenyltransferase family; Region: UbiA; pfam01040 679896005783 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 679896005784 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 679896005785 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 679896005786 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 679896005787 Repair protein; Region: Repair_PSII; pfam04536 679896005788 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 679896005789 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 679896005790 active site 679896005791 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 679896005792 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 679896005793 active site 679896005794 catalytic site [active] 679896005795 metal binding site [ion binding]; metal-binding site 679896005796 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 679896005797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 679896005798 putative substrate translocation pore; other site 679896005799 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 679896005800 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 679896005801 UDP-galactopyranose mutase; Region: GLF; pfam03275 679896005802 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 679896005803 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 679896005804 Walker A/P-loop; other site 679896005805 ATP binding site [chemical binding]; other site 679896005806 Q-loop/lid; other site 679896005807 ABC transporter signature motif; other site 679896005808 Walker B; other site 679896005809 D-loop; other site 679896005810 H-loop/switch region; other site 679896005811 FecCD transport family; Region: FecCD; pfam01032 679896005812 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 679896005813 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 679896005814 putative PBP binding regions; other site 679896005815 ABC-ATPase subunit interface; other site 679896005816 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 679896005817 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 679896005818 putative binding site residues; other site 679896005819 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 679896005820 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 679896005821 amidase catalytic site [active] 679896005822 Zn binding residues [ion binding]; other site 679896005823 substrate binding site [chemical binding]; other site 679896005824 LGFP repeat; Region: LGFP; pfam08310 679896005825 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 679896005826 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 679896005827 active site 679896005828 motif I; other site 679896005829 motif II; other site 679896005830 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 679896005831 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 679896005832 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 679896005833 putative acyl-acceptor binding pocket; other site 679896005834 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 679896005835 seryl-tRNA synthetase; Provisional; Region: PRK05431 679896005836 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 679896005837 dimer interface [polypeptide binding]; other site 679896005838 active site 679896005839 motif 1; other site 679896005840 motif 2; other site 679896005841 motif 3; other site 679896005842 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 679896005843 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 679896005844 DNA-binding site [nucleotide binding]; DNA binding site 679896005845 UTRA domain; Region: UTRA; pfam07702 679896005846 Septum formation; Region: Septum_form; pfam13845 679896005847 Septum formation; Region: Septum_form; pfam13845 679896005848 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 679896005849 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 679896005850 catalytic core [active] 679896005851 Prephenate dehydratase; Region: PDT; pfam00800 679896005852 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 679896005853 putative L-Phe binding site [chemical binding]; other site 679896005854 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 679896005855 Amidase; Region: Amidase; cl11426 679896005856 CAAX protease self-immunity; Region: Abi; pfam02517 679896005857 Transcriptional regulator [Transcription]; Region: LytR; COG1316 679896005858 Htaa; Region: HtaA; pfam04213 679896005859 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 679896005860 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 679896005861 putative active site [active] 679896005862 catalytic site [active] 679896005863 putative metal binding site [ion binding]; other site 679896005864 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 679896005865 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 679896005866 Nucleoside recognition; Region: Gate; pfam07670 679896005867 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 679896005868 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 679896005869 active site 679896005870 catalytic motif [active] 679896005871 Zn binding site [ion binding]; other site 679896005872 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 679896005873 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 679896005874 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 679896005875 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 679896005876 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 679896005877 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 679896005878 tetramer (dimer of dimers) interface [polypeptide binding]; other site 679896005879 NAD binding site [chemical binding]; other site 679896005880 dimer interface [polypeptide binding]; other site 679896005881 substrate binding site [chemical binding]; other site 679896005882 methionine sulfoxide reductase A; Provisional; Region: PRK00058 679896005883 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 679896005884 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 679896005885 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 679896005886 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 679896005887 Predicted flavoprotein [General function prediction only]; Region: COG0431 679896005888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 679896005889 putative substrate translocation pore; other site 679896005890 Major Facilitator Superfamily; Region: MFS_1; pfam07690 679896005891 Abi-like protein; Region: Abi_2; pfam07751 679896005892 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 679896005893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 679896005894 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 679896005895 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 679896005896 homodimer interface [polypeptide binding]; other site 679896005897 chemical substrate binding site [chemical binding]; other site 679896005898 oligomer interface [polypeptide binding]; other site 679896005899 metal binding site [ion binding]; metal-binding site 679896005900 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 679896005901 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 679896005902 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 679896005903 Lsr2; Region: Lsr2; pfam11774 679896005904 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 679896005905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 679896005906 active site 679896005907 phosphorylation site [posttranslational modification] 679896005908 intermolecular recognition site; other site 679896005909 dimerization interface [polypeptide binding]; other site 679896005910 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 679896005911 DNA binding residues [nucleotide binding] 679896005912 dimerization interface [polypeptide binding]; other site 679896005913 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 679896005914 Histidine kinase; Region: HisKA_3; pfam07730 679896005915 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 679896005916 ATP binding site [chemical binding]; other site 679896005917 Mg2+ binding site [ion binding]; other site 679896005918 G-X-G motif; other site 679896005919 Domain of unknown function (DUF2020); Region: DUF2020; pfam09449 679896005920 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 679896005921 active site 679896005922 catalytic site [active] 679896005923 putative inner membrane protein translocase component YidC; Validated; Region: PRK00247 679896005924 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 679896005925 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 679896005926 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 679896005927 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 679896005928 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 679896005929 Ligand Binding Site [chemical binding]; other site 679896005930 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 679896005931 Ligand Binding Site [chemical binding]; other site 679896005932 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 679896005933 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 679896005934 active site 679896005935 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 679896005936 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 679896005937 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 679896005938 Walker A/P-loop; other site 679896005939 ATP binding site [chemical binding]; other site 679896005940 Q-loop/lid; other site 679896005941 ABC transporter signature motif; other site 679896005942 Walker B; other site 679896005943 D-loop; other site 679896005944 H-loop/switch region; other site 679896005945 Predicted transcriptional regulators [Transcription]; Region: COG1725 679896005946 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 679896005947 DNA-binding site [nucleotide binding]; DNA binding site 679896005948 LabA_like proteins; Region: LabA_like; cd06167 679896005949 putative metal binding site [ion binding]; other site 679896005950 Uncharacterized conserved protein [Function unknown]; Region: COG1432 679896005951 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 679896005952 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 679896005953 catalytic residues [active] 679896005954 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 679896005955 metal-binding site [ion binding] 679896005956 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 679896005957 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 679896005958 metal-binding site [ion binding] 679896005959 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 679896005960 benzoate transport; Region: 2A0115; TIGR00895 679896005961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 679896005962 putative substrate translocation pore; other site 679896005963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 679896005964 replicative DNA helicase; Provisional; Region: PRK05636 679896005965 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 679896005966 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 679896005967 Walker A motif; other site 679896005968 ATP binding site [chemical binding]; other site 679896005969 Walker B motif; other site 679896005970 DNA binding loops [nucleotide binding] 679896005971 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 679896005972 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 679896005973 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 679896005974 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 679896005975 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 679896005976 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 679896005977 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 679896005978 dimer interface [polypeptide binding]; other site 679896005979 ssDNA binding site [nucleotide binding]; other site 679896005980 tetramer (dimer of dimers) interface [polypeptide binding]; other site 679896005981 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 679896005982 Predicted integral membrane protein [Function unknown]; Region: COG5650 679896005983 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 679896005984 Transglycosylase; Region: Transgly; pfam00912 679896005985 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 679896005986 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 679896005987 MarR family; Region: MarR; pfam01047 679896005988 MarR family; Region: MarR_2; cl17246 679896005989 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 679896005990 Ligand Binding Site [chemical binding]; other site 679896005991 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 679896005992 Ligand Binding Site [chemical binding]; other site 679896005993 short chain dehydrogenase; Provisional; Region: PRK08219 679896005994 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 679896005995 NAD(P) binding site [chemical binding]; other site 679896005996 active site 679896005997 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 679896005998 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 679896005999 active site residue [active] 679896006000 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 679896006001 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 679896006002 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 679896006003 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 679896006004 dimerization interface [polypeptide binding]; other site 679896006005 DPS ferroxidase diiron center [ion binding]; other site 679896006006 ion pore; other site 679896006007 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 679896006008 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 679896006009 putative DNA binding site [nucleotide binding]; other site 679896006010 catalytic residue [active] 679896006011 putative H2TH interface [polypeptide binding]; other site 679896006012 putative catalytic residues [active] 679896006013 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 679896006014 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 679896006015 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 679896006016 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 679896006017 putative substrate binding site [chemical binding]; other site 679896006018 putative ATP binding site [chemical binding]; other site 679896006019 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 679896006020 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 679896006021 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 679896006022 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 679896006023 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 679896006024 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 679896006025 HIGH motif; other site 679896006026 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 679896006027 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 679896006028 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 679896006029 active site 679896006030 KMSKS motif; other site 679896006031 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 679896006032 tRNA binding surface [nucleotide binding]; other site 679896006033 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 679896006034 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 679896006035 Walker A/P-loop; other site 679896006036 ATP binding site [chemical binding]; other site 679896006037 Q-loop/lid; other site 679896006038 ABC transporter signature motif; other site 679896006039 Walker B; other site 679896006040 D-loop; other site 679896006041 H-loop/switch region; other site 679896006042 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 679896006043 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 679896006044 FtsX-like permease family; Region: FtsX; pfam02687 679896006045 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 679896006046 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 679896006047 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 679896006048 Histidine kinase; Region: HisKA_3; pfam07730 679896006049 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 679896006050 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 679896006051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 679896006052 active site 679896006053 phosphorylation site [posttranslational modification] 679896006054 intermolecular recognition site; other site 679896006055 dimerization interface [polypeptide binding]; other site 679896006056 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 679896006057 DNA binding residues [nucleotide binding] 679896006058 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 679896006059 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 679896006060 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 679896006061 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 679896006062 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 679896006063 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 679896006064 active site 679896006065 trimer interface [polypeptide binding]; other site 679896006066 allosteric site; other site 679896006067 active site lid [active] 679896006068 hexamer (dimer of trimers) interface [polypeptide binding]; other site 679896006069 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 679896006070 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 679896006071 active site 679896006072 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 679896006073 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 679896006074 putative active site cavity [active] 679896006075 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 679896006076 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 679896006077 nucleotide binding site [chemical binding]; other site 679896006078 Transcriptional regulators [Transcription]; Region: FadR; COG2186 679896006079 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 679896006080 DNA-binding site [nucleotide binding]; DNA binding site 679896006081 FCD domain; Region: FCD; pfam07729 679896006082 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 679896006083 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 679896006084 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 679896006085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 679896006086 dimer interface [polypeptide binding]; other site 679896006087 conserved gate region; other site 679896006088 putative PBP binding loops; other site 679896006089 ABC-ATPase subunit interface; other site 679896006090 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 679896006091 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 679896006092 dimer interface [polypeptide binding]; other site 679896006093 conserved gate region; other site 679896006094 putative PBP binding loops; other site 679896006095 ABC-ATPase subunit interface; other site 679896006096 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 679896006097 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 679896006098 Walker A/P-loop; other site 679896006099 ATP binding site [chemical binding]; other site 679896006100 Q-loop/lid; other site 679896006101 ABC transporter signature motif; other site 679896006102 Walker B; other site 679896006103 D-loop; other site 679896006104 H-loop/switch region; other site 679896006105 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 679896006106 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 679896006107 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 679896006108 Walker A/P-loop; other site 679896006109 ATP binding site [chemical binding]; other site 679896006110 Q-loop/lid; other site 679896006111 ABC transporter signature motif; other site 679896006112 Walker B; other site 679896006113 D-loop; other site 679896006114 H-loop/switch region; other site 679896006115 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 679896006116 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 679896006117 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 679896006118 inhibitor site; inhibition site 679896006119 active site 679896006120 dimer interface [polypeptide binding]; other site 679896006121 catalytic residue [active] 679896006122 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 679896006123 active site 679896006124 catalytic residues [active] 679896006125 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 679896006126 hypothetical protein; Provisional; Region: PRK13663 679896006127 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 679896006128 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 679896006129 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 679896006130 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 679896006131 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 679896006132 substrate binding pocket [chemical binding]; other site 679896006133 substrate-Mg2+ binding site; other site 679896006134 aspartate-rich region 1; other site 679896006135 aspartate-rich region 2; other site 679896006136 phytoene desaturase; Region: crtI_fam; TIGR02734 679896006137 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 679896006138 SdpI/YhfL protein family; Region: SdpI; pfam13630 679896006139 anthranilate synthase component I; Provisional; Region: PRK13564 679896006140 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 679896006141 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 679896006142 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 679896006143 Glutamine amidotransferase class-I; Region: GATase; pfam00117 679896006144 glutamine binding [chemical binding]; other site 679896006145 catalytic triad [active] 679896006146 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 679896006147 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 679896006148 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 679896006149 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 679896006150 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 679896006151 active site 679896006152 ribulose/triose binding site [chemical binding]; other site 679896006153 phosphate binding site [ion binding]; other site 679896006154 substrate (anthranilate) binding pocket [chemical binding]; other site 679896006155 product (indole) binding pocket [chemical binding]; other site 679896006156 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 679896006157 active site 679896006158 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 679896006159 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 679896006160 pyridoxal 5'-phosphate binding site [chemical binding]; other site 679896006161 catalytic residue [active] 679896006162 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 679896006163 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 679896006164 substrate binding site [chemical binding]; other site 679896006165 active site 679896006166 catalytic residues [active] 679896006167 heterodimer interface [polypeptide binding]; other site 679896006168 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 679896006169 iron-sulfur cluster [ion binding]; other site 679896006170 [2Fe-2S] cluster binding site [ion binding]; other site 679896006171 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 679896006172 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 679896006173 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 679896006174 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 679896006175 hypothetical protein; Validated; Region: PRK00228 679896006176 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 679896006177 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 679896006178 active site 679896006179 NTP binding site [chemical binding]; other site 679896006180 metal binding triad [ion binding]; metal-binding site 679896006181 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 679896006182 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 679896006183 Zn2+ binding site [ion binding]; other site 679896006184 Mg2+ binding site [ion binding]; other site 679896006185 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 679896006186 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 679896006187 active site 679896006188 Ap6A binding site [chemical binding]; other site 679896006189 nudix motif; other site 679896006190 metal binding site [ion binding]; metal-binding site 679896006191 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 679896006192 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 679896006193 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 679896006194 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 679896006195 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 679896006196 DNA binding residues [nucleotide binding] 679896006197 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 679896006198 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 679896006199 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 679896006200 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 679896006201 catalytic residues [active] 679896006202 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 679896006203 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 679896006204 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 679896006205 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 679896006206 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 679896006207 active site 679896006208 metal binding site [ion binding]; metal-binding site 679896006209 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 679896006210 ParB-like nuclease domain; Region: ParBc; pfam02195 679896006211 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 679896006212 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 679896006213 P-loop; other site 679896006214 Magnesium ion binding site [ion binding]; other site 679896006215 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 679896006216 Magnesium ion binding site [ion binding]; other site 679896006217 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 679896006218 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 679896006219 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 679896006220 Haemolytic domain; Region: Haemolytic; pfam01809 679896006221 ribonuclease P; Reviewed; Region: rnpA; PRK03459 679896006222 Ribosomal protein L34; Region: Ribosomal_L34; cl00370