-- dump date 20140619_052059 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1087454000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 1087454000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1087454000003 Walker A motif; other site 1087454000004 ATP binding site [chemical binding]; other site 1087454000005 Walker B motif; other site 1087454000006 arginine finger; other site 1087454000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1087454000008 DnaA box-binding interface [nucleotide binding]; other site 1087454000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1087454000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1087454000011 putative DNA binding surface [nucleotide binding]; other site 1087454000012 dimer interface [polypeptide binding]; other site 1087454000013 beta-clamp/clamp loader binding surface; other site 1087454000014 beta-clamp/translesion DNA polymerase binding surface; other site 1087454000015 recombination protein F; Reviewed; Region: recF; PRK00064 1087454000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1087454000017 Walker A/P-loop; other site 1087454000018 ATP binding site [chemical binding]; other site 1087454000019 Q-loop/lid; other site 1087454000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1087454000021 ABC transporter signature motif; other site 1087454000022 Walker B; other site 1087454000023 D-loop; other site 1087454000024 H-loop/switch region; other site 1087454000025 hypothetical protein; Provisional; Region: PRK00111 1087454000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1087454000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1087454000028 ATP binding site [chemical binding]; other site 1087454000029 Mg2+ binding site [ion binding]; other site 1087454000030 G-X-G motif; other site 1087454000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1087454000032 anchoring element; other site 1087454000033 dimer interface [polypeptide binding]; other site 1087454000034 ATP binding site [chemical binding]; other site 1087454000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1087454000036 active site 1087454000037 putative metal-binding site [ion binding]; other site 1087454000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1087454000039 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1087454000040 metal binding site [ion binding]; metal-binding site 1087454000041 DNA gyrase subunit A; Validated; Region: PRK05560 1087454000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1087454000043 CAP-like domain; other site 1087454000044 active site 1087454000045 primary dimer interface [polypeptide binding]; other site 1087454000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1087454000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1087454000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1087454000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1087454000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1087454000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1087454000052 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1087454000053 YwiC-like protein; Region: YwiC; pfam14256 1087454000054 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1087454000055 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1087454000056 TM-ABC transporter signature motif; other site 1087454000057 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1087454000058 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1087454000059 Walker A/P-loop; other site 1087454000060 ATP binding site [chemical binding]; other site 1087454000061 Q-loop/lid; other site 1087454000062 ABC transporter signature motif; other site 1087454000063 Walker B; other site 1087454000064 D-loop; other site 1087454000065 H-loop/switch region; other site 1087454000066 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1087454000067 active site 1087454000068 Rhomboid family; Region: Rhomboid; pfam01694 1087454000069 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cl17348 1087454000070 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1087454000071 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1087454000072 Glycerophosphodiester phosphodiesterase-like domain of spider venom sphingomyelinases D, bacterial phospholipase D, and similar proteins; Region: GDPD_like_SMaseD_PLD; cd08576 1087454000073 putative active site [active] 1087454000074 catalytic site [active] 1087454000075 Mg binding site [ion binding]; other site 1087454000076 catalytic loop [active] 1087454000077 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1087454000078 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1087454000079 Walker A/P-loop; other site 1087454000080 ATP binding site [chemical binding]; other site 1087454000081 Q-loop/lid; other site 1087454000082 ABC transporter signature motif; other site 1087454000083 Walker B; other site 1087454000084 D-loop; other site 1087454000085 H-loop/switch region; other site 1087454000086 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1087454000087 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1087454000088 ABC-ATPase subunit interface; other site 1087454000089 dimer interface [polypeptide binding]; other site 1087454000090 putative PBP binding regions; other site 1087454000091 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1087454000092 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1087454000093 ABC-ATPase subunit interface; other site 1087454000094 dimer interface [polypeptide binding]; other site 1087454000095 putative PBP binding regions; other site 1087454000096 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1087454000097 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1087454000098 siderophore binding site; other site 1087454000099 putative septation inhibitor protein; Reviewed; Region: PRK00159 1087454000100 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1087454000101 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1087454000102 active site 1087454000103 ATP binding site [chemical binding]; other site 1087454000104 substrate binding site [chemical binding]; other site 1087454000105 activation loop (A-loop); other site 1087454000106 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1087454000107 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1087454000108 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1087454000109 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1087454000110 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1087454000111 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1087454000112 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1087454000113 active site 1087454000114 ATP binding site [chemical binding]; other site 1087454000115 substrate binding site [chemical binding]; other site 1087454000116 activation loop (A-loop); other site 1087454000117 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1087454000118 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1087454000119 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1087454000120 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1087454000121 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1087454000122 phosphopeptide binding site; other site 1087454000123 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1087454000124 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1087454000125 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1087454000126 phosphopeptide binding site; other site 1087454000127 CAAX protease self-immunity; Region: Abi; pfam02517 1087454000128 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 1087454000129 Predicted transcriptional regulators [Transcription]; Region: COG1695 1087454000130 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1087454000131 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1087454000132 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1087454000133 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1087454000134 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_2; cd11348 1087454000135 active site 1087454000136 catalytic site [active] 1087454000137 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1087454000138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087454000139 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1087454000140 putative substrate translocation pore; other site 1087454000141 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1087454000142 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 1087454000143 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1087454000144 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1087454000145 DNA binding residues [nucleotide binding] 1087454000146 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1087454000147 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1087454000148 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1087454000149 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1087454000150 catalytic residues [active] 1087454000151 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1087454000152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087454000153 dimer interface [polypeptide binding]; other site 1087454000154 conserved gate region; other site 1087454000155 putative PBP binding loops; other site 1087454000156 ABC-ATPase subunit interface; other site 1087454000157 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1087454000158 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1087454000159 Walker A/P-loop; other site 1087454000160 ATP binding site [chemical binding]; other site 1087454000161 Q-loop/lid; other site 1087454000162 ABC transporter signature motif; other site 1087454000163 Walker B; other site 1087454000164 D-loop; other site 1087454000165 H-loop/switch region; other site 1087454000166 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1087454000167 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1087454000168 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 1087454000169 putative metal binding site [ion binding]; other site 1087454000170 biotin synthase; Validated; Region: PRK06256 1087454000171 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1087454000172 FeS/SAM binding site; other site 1087454000173 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1087454000174 MepB protein; Region: MepB; cl01985 1087454000175 AMP nucleosidase; Provisional; Region: PRK08292 1087454000176 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1087454000177 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1087454000178 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 1087454000179 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1087454000180 active site 1087454000181 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1087454000182 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1087454000183 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1087454000184 Lipase (class 2); Region: Lipase_2; pfam01674 1087454000185 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370 1087454000186 dimer interface [polypeptide binding]; other site 1087454000187 FMN binding site [chemical binding]; other site 1087454000188 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1087454000189 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1087454000190 trimer interface [polypeptide binding]; other site 1087454000191 putative metal binding site [ion binding]; other site 1087454000192 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1087454000193 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1087454000194 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1087454000195 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1087454000196 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1087454000197 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1087454000198 Coenzyme A binding pocket [chemical binding]; other site 1087454000199 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1087454000200 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1087454000201 MarR family; Region: MarR; pfam01047 1087454000202 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1087454000203 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1087454000204 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1087454000205 hypothetical protein; Provisional; Region: PRK10621 1087454000206 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1087454000207 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1087454000208 active site 1087454000209 phosphorylation site [posttranslational modification] 1087454000210 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1087454000211 active site 1087454000212 P-loop; other site 1087454000213 phosphorylation site [posttranslational modification] 1087454000214 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1087454000215 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 1087454000216 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1087454000217 ATP binding site [chemical binding]; other site 1087454000218 putative Mg++ binding site [ion binding]; other site 1087454000219 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1087454000220 nucleotide binding region [chemical binding]; other site 1087454000221 ATP-binding site [chemical binding]; other site 1087454000222 Helicase associated domain (HA2); Region: HA2; pfam04408 1087454000223 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1087454000224 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 1087454000225 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1087454000226 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1087454000227 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1087454000228 NAD(P) binding site [chemical binding]; other site 1087454000229 active site 1087454000230 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1087454000231 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1087454000232 RNA binding surface [nucleotide binding]; other site 1087454000233 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1087454000234 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1087454000235 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1087454000236 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1087454000237 DNA binding site [nucleotide binding] 1087454000238 active site 1087454000239 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1087454000240 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1087454000241 active site 1087454000242 glycerol kinase; Provisional; Region: glpK; PRK00047 1087454000243 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1087454000244 nucleotide binding site [chemical binding]; other site 1087454000245 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1087454000246 amphipathic channel; other site 1087454000247 Asn-Pro-Ala signature motifs; other site 1087454000248 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1087454000249 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1087454000250 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1087454000251 active site 1087454000252 Zn binding site [ion binding]; other site 1087454000253 Protease prsW family; Region: PrsW-protease; pfam13367 1087454000254 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1087454000255 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1087454000256 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1087454000257 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 1087454000258 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 1087454000259 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1087454000260 classical (c) SDRs; Region: SDR_c; cd05233 1087454000261 NAD(P) binding site [chemical binding]; other site 1087454000262 active site 1087454000263 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1087454000264 FAD binding domain; Region: FAD_binding_4; pfam01565 1087454000265 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1087454000266 Predicted membrane protein [Function unknown]; Region: COG2246 1087454000267 GtrA-like protein; Region: GtrA; pfam04138 1087454000268 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1087454000269 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1087454000270 active site 1087454000271 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1087454000272 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1087454000273 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1087454000274 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1087454000275 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1087454000276 ABC-ATPase subunit interface; other site 1087454000277 dimer interface [polypeptide binding]; other site 1087454000278 putative PBP binding regions; other site 1087454000279 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1087454000280 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1087454000281 active site 1087454000282 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1087454000283 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1087454000284 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1087454000285 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1087454000286 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1087454000287 NAD(P) binding site [chemical binding]; other site 1087454000288 CAT RNA binding domain; Region: CAT_RBD; smart01061 1087454000289 PRD domain; Region: PRD; pfam00874 1087454000290 PRD domain; Region: PRD; pfam00874 1087454000291 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1087454000292 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1087454000293 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1087454000294 homodimer interface [polypeptide binding]; other site 1087454000295 catalytic residue [active] 1087454000296 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1087454000297 DNA-binding site [nucleotide binding]; DNA binding site 1087454000298 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1087454000299 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1087454000300 active site 1087454000301 multimer interface [polypeptide binding]; other site 1087454000302 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1087454000303 predicted active site [active] 1087454000304 catalytic triad [active] 1087454000305 prephenate dehydrogenase; Validated; Region: PRK06545 1087454000306 prephenate dehydrogenase; Validated; Region: PRK08507 1087454000307 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1087454000308 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1087454000309 nucleoside/Zn binding site; other site 1087454000310 dimer interface [polypeptide binding]; other site 1087454000311 catalytic motif [active] 1087454000312 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1087454000313 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1087454000314 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1087454000315 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1087454000316 active site 1087454000317 KMSKS motif; other site 1087454000318 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1087454000319 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1087454000320 Shikimate kinase; Region: SKI; pfam01202 1087454000321 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1087454000322 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 1087454000323 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 1087454000324 putative NAD(P) binding site [chemical binding]; other site 1087454000325 catalytic Zn binding site [ion binding]; other site 1087454000326 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 1087454000327 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1087454000328 NADP binding site [chemical binding]; other site 1087454000329 homodimer interface [polypeptide binding]; other site 1087454000330 active site 1087454000331 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1087454000332 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1087454000333 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1087454000334 homodimer interface [polypeptide binding]; other site 1087454000335 catalytic residue [active] 1087454000336 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1087454000337 hypothetical protein; Validated; Region: PRK00153 1087454000338 recombination protein RecR; Reviewed; Region: recR; PRK00076 1087454000339 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 1087454000340 RecR protein; Region: RecR; pfam02132 1087454000341 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1087454000342 putative active site [active] 1087454000343 putative metal-binding site [ion binding]; other site 1087454000344 tetramer interface [polypeptide binding]; other site 1087454000345 putative transporter; Provisional; Region: PRK09821 1087454000346 GntP family permease; Region: GntP_permease; pfam02447 1087454000347 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1087454000348 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1087454000349 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1087454000350 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1087454000351 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1087454000352 DNA-binding site [nucleotide binding]; DNA binding site 1087454000353 FCD domain; Region: FCD; pfam07729 1087454000354 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1087454000355 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1087454000356 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1087454000357 catalytic triad [active] 1087454000358 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1087454000359 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1087454000360 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1087454000361 DNA polymerase III subunit epsilon; Validated; Region: PRK05601 1087454000362 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1087454000363 active site 1087454000364 catalytic site [active] 1087454000365 substrate binding site [chemical binding]; other site 1087454000366 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 1087454000367 2-isopropylmalate synthase; Validated; Region: PRK03739 1087454000368 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1087454000369 active site 1087454000370 catalytic residues [active] 1087454000371 metal binding site [ion binding]; metal-binding site 1087454000372 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1087454000373 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1087454000374 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1087454000375 DNA binding residues [nucleotide binding] 1087454000376 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1087454000377 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1087454000378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087454000379 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1087454000380 putative substrate translocation pore; other site 1087454000381 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1087454000382 intersubunit interface [polypeptide binding]; other site 1087454000383 active site 1087454000384 catalytic residue [active] 1087454000385 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1087454000386 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1087454000387 active site 1087454000388 substrate binding site [chemical binding]; other site 1087454000389 metal binding site [ion binding]; metal-binding site 1087454000390 Cna protein B-type domain; Region: Cna_B; pfam05738 1087454000391 Cna protein B-type domain; Region: Cna_B; pfam05738 1087454000392 aspartate kinase; Reviewed; Region: PRK06635 1087454000393 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1087454000394 putative nucleotide binding site [chemical binding]; other site 1087454000395 putative catalytic residues [active] 1087454000396 putative Mg ion binding site [ion binding]; other site 1087454000397 putative aspartate binding site [chemical binding]; other site 1087454000398 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1087454000399 putative allosteric regulatory site; other site 1087454000400 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1087454000401 putative allosteric regulatory residue; other site 1087454000402 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1087454000403 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1087454000404 RNA polymerase sigma factor; Provisional; Region: PRK12535 1087454000405 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1087454000406 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1087454000407 DNA binding residues [nucleotide binding] 1087454000408 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1087454000409 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1087454000410 heme binding pocket [chemical binding]; other site 1087454000411 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1087454000412 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1087454000413 Walker A/P-loop; other site 1087454000414 ATP binding site [chemical binding]; other site 1087454000415 Q-loop/lid; other site 1087454000416 ABC transporter signature motif; other site 1087454000417 Walker B; other site 1087454000418 D-loop; other site 1087454000419 H-loop/switch region; other site 1087454000420 TOBE domain; Region: TOBE_2; pfam08402 1087454000421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087454000422 dimer interface [polypeptide binding]; other site 1087454000423 conserved gate region; other site 1087454000424 ABC-ATPase subunit interface; other site 1087454000425 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1087454000426 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1087454000427 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1087454000428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087454000429 putative substrate translocation pore; other site 1087454000430 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1087454000431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1087454000432 active site 1087454000433 phosphorylation site [posttranslational modification] 1087454000434 intermolecular recognition site; other site 1087454000435 dimerization interface [polypeptide binding]; other site 1087454000436 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1087454000437 DNA binding site [nucleotide binding] 1087454000438 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1087454000439 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1087454000440 dimer interface [polypeptide binding]; other site 1087454000441 phosphorylation site [posttranslational modification] 1087454000442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1087454000443 ATP binding site [chemical binding]; other site 1087454000444 Mg2+ binding site [ion binding]; other site 1087454000445 G-X-G motif; other site 1087454000446 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 1087454000447 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612 1087454000448 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654 1087454000449 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 1087454000450 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1087454000451 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 1087454000452 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1087454000453 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1087454000454 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1087454000455 putative active site [active] 1087454000456 putative metal binding site [ion binding]; other site 1087454000457 Yqey-like protein; Region: YqeY; pfam09424 1087454000458 Transglycosylase; Region: Transgly; pfam00912 1087454000459 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1087454000460 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1087454000461 PASTA domain; Region: PASTA; pfam03793 1087454000462 Transcription factor WhiB; Region: Whib; pfam02467 1087454000463 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1087454000464 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1087454000465 homotrimer interaction site [polypeptide binding]; other site 1087454000466 putative active site [active] 1087454000467 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1087454000468 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1087454000469 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1087454000470 ligand binding site [chemical binding]; other site 1087454000471 flexible hinge region; other site 1087454000472 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1087454000473 putative switch regulator; other site 1087454000474 non-specific DNA interactions [nucleotide binding]; other site 1087454000475 DNA binding site [nucleotide binding] 1087454000476 sequence specific DNA binding site [nucleotide binding]; other site 1087454000477 putative cAMP binding site [chemical binding]; other site 1087454000478 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1087454000479 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1087454000480 minor groove reading motif; other site 1087454000481 helix-hairpin-helix signature motif; other site 1087454000482 substrate binding pocket [chemical binding]; other site 1087454000483 active site 1087454000484 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1087454000485 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1087454000486 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1087454000487 catalytic residues [active] 1087454000488 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1087454000489 putative active site [active] 1087454000490 putative CoA binding site [chemical binding]; other site 1087454000491 nudix motif; other site 1087454000492 metal binding site [ion binding]; metal-binding site 1087454000493 Colicin V production protein; Region: Colicin_V; pfam02674 1087454000494 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1087454000495 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1087454000496 active site 1087454000497 substrate binding sites [chemical binding]; other site 1087454000498 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1087454000499 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1087454000500 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1087454000501 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1087454000502 motif II; other site 1087454000503 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1087454000504 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1087454000505 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1087454000506 ATP binding site [chemical binding]; other site 1087454000507 Walker A motif; other site 1087454000508 hexamer interface [polypeptide binding]; other site 1087454000509 Walker B motif; other site 1087454000510 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1087454000511 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1087454000512 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 1087454000513 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1087454000514 DNA-binding site [nucleotide binding]; DNA binding site 1087454000515 RNA-binding motif; other site 1087454000516 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1087454000517 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1087454000518 active site 1087454000519 interdomain interaction site; other site 1087454000520 putative metal-binding site [ion binding]; other site 1087454000521 nucleotide binding site [chemical binding]; other site 1087454000522 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1087454000523 domain I; other site 1087454000524 DNA binding groove [nucleotide binding] 1087454000525 phosphate binding site [ion binding]; other site 1087454000526 domain II; other site 1087454000527 domain III; other site 1087454000528 nucleotide binding site [chemical binding]; other site 1087454000529 catalytic site [active] 1087454000530 domain IV; other site 1087454000531 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1087454000532 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1087454000533 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1087454000534 Predicted membrane protein [Function unknown]; Region: COG1297 1087454000535 putative oligopeptide transporter, OPT family; Region: TIGR00733 1087454000536 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1087454000537 dimerization interface [polypeptide binding]; other site 1087454000538 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1087454000539 cyclase homology domain; Region: CHD; cd07302 1087454000540 nucleotidyl binding site; other site 1087454000541 metal binding site [ion binding]; metal-binding site 1087454000542 dimer interface [polypeptide binding]; other site 1087454000543 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1087454000544 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1087454000545 acyl-CoA synthetase; Validated; Region: PRK07788 1087454000546 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1087454000547 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1087454000548 acyl-activating enzyme (AAE) consensus motif; other site 1087454000549 acyl-activating enzyme (AAE) consensus motif; other site 1087454000550 AMP binding site [chemical binding]; other site 1087454000551 active site 1087454000552 CoA binding site [chemical binding]; other site 1087454000553 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1087454000554 active site 1087454000555 catalytic triad [active] 1087454000556 oxyanion hole [active] 1087454000557 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1087454000558 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1087454000559 substrate binding site; other site 1087454000560 tetramer interface; other site 1087454000561 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1087454000562 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1087454000563 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1087454000564 NADP binding site [chemical binding]; other site 1087454000565 active site 1087454000566 putative substrate binding site [chemical binding]; other site 1087454000567 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1087454000568 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1087454000569 NAD binding site [chemical binding]; other site 1087454000570 substrate binding site [chemical binding]; other site 1087454000571 homodimer interface [polypeptide binding]; other site 1087454000572 active site 1087454000573 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1087454000574 Zn binding site [ion binding]; other site 1087454000575 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1087454000576 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1087454000577 Putative esterase; Region: Esterase; pfam00756 1087454000578 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1087454000579 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1087454000580 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1087454000581 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1087454000582 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1087454000583 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1087454000584 non-specific DNA binding site [nucleotide binding]; other site 1087454000585 salt bridge; other site 1087454000586 sequence-specific DNA binding site [nucleotide binding]; other site 1087454000587 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1087454000588 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1087454000589 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1087454000590 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 1087454000591 L-aspartate oxidase; Provisional; Region: PRK06175 1087454000592 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1087454000593 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 1087454000594 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1087454000595 Predicted membrane protein [Function unknown]; Region: COG2733 1087454000596 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1087454000597 Class I aldolases; Region: Aldolase_Class_I; cl17187 1087454000598 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1087454000599 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1087454000600 FeS/SAM binding site; other site 1087454000601 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 1087454000602 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1087454000603 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1087454000604 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1087454000605 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1087454000606 FAD binding domain; Region: FAD_binding_4; pfam01565 1087454000607 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1087454000608 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 1087454000609 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1087454000610 acyl-activating enzyme (AAE) consensus motif; other site 1087454000611 putative AMP binding site [chemical binding]; other site 1087454000612 putative active site [active] 1087454000613 putative CoA binding site [chemical binding]; other site 1087454000614 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1087454000615 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1087454000616 putative ADP-binding pocket [chemical binding]; other site 1087454000617 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1087454000618 catalytic core [active] 1087454000619 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1087454000620 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1087454000621 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1087454000622 dimer interface [polypeptide binding]; other site 1087454000623 phosphorylation site [posttranslational modification] 1087454000624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1087454000625 ATP binding site [chemical binding]; other site 1087454000626 Mg2+ binding site [ion binding]; other site 1087454000627 G-X-G motif; other site 1087454000628 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1087454000629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1087454000630 active site 1087454000631 phosphorylation site [posttranslational modification] 1087454000632 intermolecular recognition site; other site 1087454000633 dimerization interface [polypeptide binding]; other site 1087454000634 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1087454000635 DNA binding site [nucleotide binding] 1087454000636 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1087454000637 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1087454000638 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1087454000639 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1087454000640 DNA binding domain, excisionase family; Region: excise; TIGR01764 1087454000641 Thioredoxin; Region: Thioredoxin_4; cl17273 1087454000642 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1087454000643 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1087454000644 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1087454000645 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1087454000646 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1087454000647 motif II; other site 1087454000648 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1087454000649 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1087454000650 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1087454000651 tRNA; other site 1087454000652 putative tRNA binding site [nucleotide binding]; other site 1087454000653 putative NADP binding site [chemical binding]; other site 1087454000654 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1087454000655 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1087454000656 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1087454000657 domain interfaces; other site 1087454000658 active site 1087454000659 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1087454000660 active site 1087454000661 homodimer interface [polypeptide binding]; other site 1087454000662 SAM binding site [chemical binding]; other site 1087454000663 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1087454000664 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1087454000665 active site 1087454000666 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1087454000667 dimer interface [polypeptide binding]; other site 1087454000668 active site 1087454000669 Schiff base residues; other site 1087454000670 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1087454000671 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1087454000672 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1087454000673 substrate binding site [chemical binding]; other site 1087454000674 active site 1087454000675 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1087454000676 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1087454000677 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1087454000678 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1087454000679 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1087454000680 inhibitor-cofactor binding pocket; inhibition site 1087454000681 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1087454000682 catalytic residue [active] 1087454000683 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1087454000684 catalytic core [active] 1087454000685 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1087454000686 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1087454000687 catalytic residues [active] 1087454000688 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1087454000689 ResB-like family; Region: ResB; pfam05140 1087454000690 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1087454000691 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1087454000692 S-adenosylmethionine binding site [chemical binding]; other site 1087454000693 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1087454000694 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1087454000695 Walker A/P-loop; other site 1087454000696 ATP binding site [chemical binding]; other site 1087454000697 Q-loop/lid; other site 1087454000698 ABC transporter signature motif; other site 1087454000699 Walker B; other site 1087454000700 D-loop; other site 1087454000701 H-loop/switch region; other site 1087454000702 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1087454000703 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1087454000704 intersubunit interface [polypeptide binding]; other site 1087454000705 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1087454000706 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1087454000707 ABC-ATPase subunit interface; other site 1087454000708 dimer interface [polypeptide binding]; other site 1087454000709 putative PBP binding regions; other site 1087454000710 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 1087454000711 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1087454000712 UbiA prenyltransferase family; Region: UbiA; pfam01040 1087454000713 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1087454000714 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1087454000715 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1087454000716 acyl-activating enzyme (AAE) consensus motif; other site 1087454000717 acyl-activating enzyme (AAE) consensus motif; other site 1087454000718 AMP binding site [chemical binding]; other site 1087454000719 active site 1087454000720 CoA binding site [chemical binding]; other site 1087454000721 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1087454000722 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1087454000723 substrate binding site [chemical binding]; other site 1087454000724 oxyanion hole (OAH) forming residues; other site 1087454000725 trimer interface [polypeptide binding]; other site 1087454000726 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1087454000727 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 1087454000728 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1087454000729 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1087454000730 active site 1087454000731 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1087454000732 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1087454000733 dimer interface [polypeptide binding]; other site 1087454000734 tetramer interface [polypeptide binding]; other site 1087454000735 PYR/PP interface [polypeptide binding]; other site 1087454000736 TPP binding site [chemical binding]; other site 1087454000737 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1087454000738 TPP-binding site; other site 1087454000739 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1087454000740 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1087454000741 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1087454000742 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1087454000743 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1087454000744 S-adenosylmethionine binding site [chemical binding]; other site 1087454000745 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1087454000746 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1087454000747 NAD(P) binding site [chemical binding]; other site 1087454000748 LDH/MDH dimer interface [polypeptide binding]; other site 1087454000749 substrate binding site [chemical binding]; other site 1087454000750 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1087454000751 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1087454000752 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1087454000753 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1087454000754 substrate binding pocket [chemical binding]; other site 1087454000755 chain length determination region; other site 1087454000756 substrate-Mg2+ binding site; other site 1087454000757 catalytic residues [active] 1087454000758 aspartate-rich region 1; other site 1087454000759 active site lid residues [active] 1087454000760 aspartate-rich region 2; other site 1087454000761 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1087454000762 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1087454000763 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1087454000764 putative homodimer interface [polypeptide binding]; other site 1087454000765 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1087454000766 heterodimer interface [polypeptide binding]; other site 1087454000767 homodimer interface [polypeptide binding]; other site 1087454000768 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1087454000769 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1087454000770 23S rRNA interface [nucleotide binding]; other site 1087454000771 L7/L12 interface [polypeptide binding]; other site 1087454000772 putative thiostrepton binding site; other site 1087454000773 L25 interface [polypeptide binding]; other site 1087454000774 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1087454000775 mRNA/rRNA interface [nucleotide binding]; other site 1087454000776 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1087454000777 trimer interface [polypeptide binding]; other site 1087454000778 active site 1087454000779 G bulge; other site 1087454000780 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1087454000781 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1087454000782 FMN binding site [chemical binding]; other site 1087454000783 active site 1087454000784 substrate binding site [chemical binding]; other site 1087454000785 catalytic residue [active] 1087454000786 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1087454000787 23S rRNA interface [nucleotide binding]; other site 1087454000788 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1087454000789 50S ribosomal protein L7/L12; Reviewed; Region: rplL; PRK00157 1087454000790 L11 interface [polypeptide binding]; other site 1087454000791 putative EF-Tu interaction site [polypeptide binding]; other site 1087454000792 putative EF-G interaction site [polypeptide binding]; other site 1087454000793 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1087454000794 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 1087454000795 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1087454000796 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1087454000797 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1087454000798 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1087454000799 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1087454000800 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 1087454000801 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1087454000802 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1087454000803 ABC-ATPase subunit interface; other site 1087454000804 dimer interface [polypeptide binding]; other site 1087454000805 putative PBP binding regions; other site 1087454000806 Ethylene insensitive 3; Region: EIN3; cl04813 1087454000807 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1087454000808 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1087454000809 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1087454000810 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1087454000811 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1087454000812 RPB1 interaction site [polypeptide binding]; other site 1087454000813 RPB10 interaction site [polypeptide binding]; other site 1087454000814 RPB11 interaction site [polypeptide binding]; other site 1087454000815 RPB3 interaction site [polypeptide binding]; other site 1087454000816 RPB12 interaction site [polypeptide binding]; other site 1087454000817 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1087454000818 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1087454000819 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1087454000820 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1087454000821 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1087454000822 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1087454000823 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1087454000824 G-loop; other site 1087454000825 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1087454000826 DNA binding site [nucleotide binding] 1087454000827 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1087454000828 Histidine kinase; Region: HisKA_3; pfam07730 1087454000829 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1087454000830 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1087454000831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1087454000832 active site 1087454000833 phosphorylation site [posttranslational modification] 1087454000834 intermolecular recognition site; other site 1087454000835 dimerization interface [polypeptide binding]; other site 1087454000836 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1087454000837 DNA binding residues [nucleotide binding] 1087454000838 dimerization interface [polypeptide binding]; other site 1087454000839 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1087454000840 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1087454000841 Walker A/P-loop; other site 1087454000842 ATP binding site [chemical binding]; other site 1087454000843 Q-loop/lid; other site 1087454000844 ABC transporter signature motif; other site 1087454000845 Walker B; other site 1087454000846 D-loop; other site 1087454000847 H-loop/switch region; other site 1087454000848 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1087454000849 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1087454000850 TIGR03943 family protein; Region: TIGR03943 1087454000851 Predicted permease; Region: DUF318; cl17795 1087454000852 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 1087454000853 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1087454000854 FeS/SAM binding site; other site 1087454000855 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 1087454000856 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1087454000857 effector binding site; other site 1087454000858 active site 1087454000859 Zn binding site [ion binding]; other site 1087454000860 glycine loop; other site 1087454000861 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1087454000862 S17 interaction site [polypeptide binding]; other site 1087454000863 S8 interaction site; other site 1087454000864 16S rRNA interaction site [nucleotide binding]; other site 1087454000865 streptomycin interaction site [chemical binding]; other site 1087454000866 23S rRNA interaction site [nucleotide binding]; other site 1087454000867 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1087454000868 30S ribosomal protein S7; Validated; Region: PRK05302 1087454000869 elongation factor G; Reviewed; Region: PRK00007 1087454000870 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1087454000871 G1 box; other site 1087454000872 putative GEF interaction site [polypeptide binding]; other site 1087454000873 GTP/Mg2+ binding site [chemical binding]; other site 1087454000874 Switch I region; other site 1087454000875 G2 box; other site 1087454000876 G3 box; other site 1087454000877 Switch II region; other site 1087454000878 G4 box; other site 1087454000879 G5 box; other site 1087454000880 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1087454000881 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1087454000882 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1087454000883 elongation factor Tu; Reviewed; Region: PRK00049 1087454000884 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1087454000885 G1 box; other site 1087454000886 GEF interaction site [polypeptide binding]; other site 1087454000887 GTP/Mg2+ binding site [chemical binding]; other site 1087454000888 Switch I region; other site 1087454000889 G2 box; other site 1087454000890 G3 box; other site 1087454000891 Switch II region; other site 1087454000892 G4 box; other site 1087454000893 G5 box; other site 1087454000894 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1087454000895 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1087454000896 Antibiotic Binding Site [chemical binding]; other site 1087454000897 Asp23 family; Region: Asp23; cl00574 1087454000898 Asp23 family; Region: Asp23; cl00574 1087454000899 Asp23 family; Region: Asp23; pfam03780 1087454000900 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1087454000901 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1087454000902 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1087454000903 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1087454000904 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1087454000905 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1087454000906 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1087454000907 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1087454000908 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1087454000909 putative translocon binding site; other site 1087454000910 protein-rRNA interface [nucleotide binding]; other site 1087454000911 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1087454000912 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1087454000913 G-X-X-G motif; other site 1087454000914 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1087454000915 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1087454000916 23S rRNA interface [nucleotide binding]; other site 1087454000917 5S rRNA interface [nucleotide binding]; other site 1087454000918 putative antibiotic binding site [chemical binding]; other site 1087454000919 L25 interface [polypeptide binding]; other site 1087454000920 L27 interface [polypeptide binding]; other site 1087454000921 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1087454000922 putative translocon interaction site; other site 1087454000923 23S rRNA interface [nucleotide binding]; other site 1087454000924 signal recognition particle (SRP54) interaction site; other site 1087454000925 L23 interface [polypeptide binding]; other site 1087454000926 trigger factor interaction site; other site 1087454000927 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1087454000928 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1087454000929 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1087454000930 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1087454000931 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1087454000932 Walker A/P-loop; other site 1087454000933 ATP binding site [chemical binding]; other site 1087454000934 Q-loop/lid; other site 1087454000935 ABC transporter signature motif; other site 1087454000936 Walker B; other site 1087454000937 D-loop; other site 1087454000938 H-loop/switch region; other site 1087454000939 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1087454000940 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1087454000941 Walker A/P-loop; other site 1087454000942 ATP binding site [chemical binding]; other site 1087454000943 Q-loop/lid; other site 1087454000944 ABC transporter signature motif; other site 1087454000945 Walker B; other site 1087454000946 D-loop; other site 1087454000947 H-loop/switch region; other site 1087454000948 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1087454000949 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1087454000950 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087454000951 dimer interface [polypeptide binding]; other site 1087454000952 conserved gate region; other site 1087454000953 putative PBP binding loops; other site 1087454000954 ABC-ATPase subunit interface; other site 1087454000955 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1087454000956 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087454000957 putative PBP binding loops; other site 1087454000958 dimer interface [polypeptide binding]; other site 1087454000959 ABC-ATPase subunit interface; other site 1087454000960 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1087454000961 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1087454000962 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1087454000963 RNA binding site [nucleotide binding]; other site 1087454000964 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1087454000965 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1087454000966 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1087454000967 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1087454000968 serine transporter; Region: stp; TIGR00814 1087454000969 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1087454000970 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1087454000971 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1087454000972 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1087454000973 active site 1087454000974 homotetramer interface [polypeptide binding]; other site 1087454000975 homodimer interface [polypeptide binding]; other site 1087454000976 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1087454000977 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1087454000978 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1087454000979 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1087454000980 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1087454000981 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1087454000982 5S rRNA interface [nucleotide binding]; other site 1087454000983 23S rRNA interface [nucleotide binding]; other site 1087454000984 L5 interface [polypeptide binding]; other site 1087454000985 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1087454000986 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1087454000987 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1087454000988 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1087454000989 23S rRNA binding site [nucleotide binding]; other site 1087454000990 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1087454000991 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1087454000992 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1087454000993 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1087454000994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087454000995 dimer interface [polypeptide binding]; other site 1087454000996 conserved gate region; other site 1087454000997 putative PBP binding loops; other site 1087454000998 ABC-ATPase subunit interface; other site 1087454000999 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 1087454001000 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 1087454001001 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1087454001002 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1087454001003 Walker A/P-loop; other site 1087454001004 ATP binding site [chemical binding]; other site 1087454001005 Q-loop/lid; other site 1087454001006 ABC transporter signature motif; other site 1087454001007 Walker B; other site 1087454001008 D-loop; other site 1087454001009 H-loop/switch region; other site 1087454001010 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1087454001011 SecY translocase; Region: SecY; pfam00344 1087454001012 adenylate kinase; Reviewed; Region: adk; PRK00279 1087454001013 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1087454001014 AMP-binding site [chemical binding]; other site 1087454001015 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1087454001016 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1087454001017 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1087454001018 rRNA binding site [nucleotide binding]; other site 1087454001019 predicted 30S ribosome binding site; other site 1087454001020 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 1087454001021 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1087454001022 30S ribosomal protein S11; Validated; Region: PRK05309 1087454001023 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1087454001024 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1087454001025 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1087454001026 RNA binding surface [nucleotide binding]; other site 1087454001027 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1087454001028 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1087454001029 alphaNTD - beta interaction site [polypeptide binding]; other site 1087454001030 alphaNTD homodimer interface [polypeptide binding]; other site 1087454001031 alphaNTD - beta' interaction site [polypeptide binding]; other site 1087454001032 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1087454001033 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1087454001034 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1087454001035 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1087454001036 dimerization interface 3.5A [polypeptide binding]; other site 1087454001037 active site 1087454001038 Protein of unknown function (DUF690); Region: DUF690; cl04939 1087454001039 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 1087454001040 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1087454001041 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1087454001042 active site 1087454001043 catalytic residues [active] 1087454001044 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1087454001045 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1087454001046 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1087454001047 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1087454001048 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1087454001049 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1087454001050 Walker A/P-loop; other site 1087454001051 ATP binding site [chemical binding]; other site 1087454001052 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1087454001053 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1087454001054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1087454001055 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1087454001056 23S rRNA interface [nucleotide binding]; other site 1087454001057 L3 interface [polypeptide binding]; other site 1087454001058 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1087454001059 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1087454001060 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1087454001061 active site 1087454001062 substrate binding site [chemical binding]; other site 1087454001063 metal binding site [ion binding]; metal-binding site 1087454001064 alanine racemase; Reviewed; Region: alr; PRK00053 1087454001065 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1087454001066 active site 1087454001067 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1087454001068 dimer interface [polypeptide binding]; other site 1087454001069 substrate binding site [chemical binding]; other site 1087454001070 catalytic residues [active] 1087454001071 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1087454001072 Predicted permease [General function prediction only]; Region: COG2985 1087454001073 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1087454001074 TrkA-C domain; Region: TrkA_C; pfam02080 1087454001075 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1087454001076 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1087454001077 Glycoprotease family; Region: Peptidase_M22; pfam00814 1087454001078 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1087454001079 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1087454001080 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1087454001081 Coenzyme A binding pocket [chemical binding]; other site 1087454001082 UGMP family protein; Validated; Region: PRK09604 1087454001083 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1087454001084 oligomerisation interface [polypeptide binding]; other site 1087454001085 mobile loop; other site 1087454001086 roof hairpin; other site 1087454001087 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1087454001088 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1087454001089 ring oligomerisation interface [polypeptide binding]; other site 1087454001090 ATP/Mg binding site [chemical binding]; other site 1087454001091 stacking interactions; other site 1087454001092 hinge regions; other site 1087454001093 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1087454001094 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1087454001095 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1087454001096 DNA binding residues [nucleotide binding] 1087454001097 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1087454001098 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1087454001099 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1087454001100 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1087454001101 active site 1087454001102 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1087454001103 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1087454001104 phosphate binding site [ion binding]; other site 1087454001105 GMP synthase; Reviewed; Region: guaA; PRK00074 1087454001106 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1087454001107 AMP/PPi binding site [chemical binding]; other site 1087454001108 candidate oxyanion hole; other site 1087454001109 catalytic triad [active] 1087454001110 potential glutamine specificity residues [chemical binding]; other site 1087454001111 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1087454001112 ATP Binding subdomain [chemical binding]; other site 1087454001113 Ligand Binding sites [chemical binding]; other site 1087454001114 Dimerization subdomain; other site 1087454001115 PspC domain; Region: PspC; cl00864 1087454001116 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1087454001117 PspC domain; Region: PspC; pfam04024 1087454001118 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1087454001119 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1087454001120 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1087454001121 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1087454001122 active site 1087454001123 phosphorylation site [posttranslational modification] 1087454001124 intermolecular recognition site; other site 1087454001125 dimerization interface [polypeptide binding]; other site 1087454001126 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1087454001127 dimerization interface [polypeptide binding]; other site 1087454001128 DNA binding residues [nucleotide binding] 1087454001129 AMIN domain; Region: AMIN; pfam11741 1087454001130 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 1087454001131 putative dimer interface [polypeptide binding]; other site 1087454001132 putative [2Fe-2S] cluster binding site [ion binding]; other site 1087454001133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087454001134 dimer interface [polypeptide binding]; other site 1087454001135 conserved gate region; other site 1087454001136 ABC-ATPase subunit interface; other site 1087454001137 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1087454001138 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1087454001139 Walker A/P-loop; other site 1087454001140 ATP binding site [chemical binding]; other site 1087454001141 Q-loop/lid; other site 1087454001142 ABC transporter signature motif; other site 1087454001143 Walker B; other site 1087454001144 D-loop; other site 1087454001145 H-loop/switch region; other site 1087454001146 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1087454001147 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1087454001148 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1087454001149 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1087454001150 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1087454001151 intersubunit interface [polypeptide binding]; other site 1087454001152 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1087454001153 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1087454001154 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1087454001155 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1087454001156 ABC-ATPase subunit interface; other site 1087454001157 dimer interface [polypeptide binding]; other site 1087454001158 putative PBP binding regions; other site 1087454001159 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1087454001160 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1087454001161 ABC-ATPase subunit interface; other site 1087454001162 dimer interface [polypeptide binding]; other site 1087454001163 putative PBP binding regions; other site 1087454001164 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1087454001165 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1087454001166 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1087454001167 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1087454001168 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1087454001169 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1087454001170 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1087454001171 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1087454001172 homodimer interface [polypeptide binding]; other site 1087454001173 NADP binding site [chemical binding]; other site 1087454001174 substrate binding site [chemical binding]; other site 1087454001175 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1087454001176 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1087454001177 active site 1087454001178 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1087454001179 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1087454001180 Htaa; Region: HtaA; pfam04213 1087454001181 Htaa; Region: HtaA; pfam04213 1087454001182 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 1087454001183 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1087454001184 intersubunit interface [polypeptide binding]; other site 1087454001185 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1087454001186 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1087454001187 ABC-ATPase subunit interface; other site 1087454001188 dimer interface [polypeptide binding]; other site 1087454001189 putative PBP binding regions; other site 1087454001190 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1087454001191 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1087454001192 Walker A/P-loop; other site 1087454001193 ATP binding site [chemical binding]; other site 1087454001194 Q-loop/lid; other site 1087454001195 ABC transporter signature motif; other site 1087454001196 Walker B; other site 1087454001197 D-loop; other site 1087454001198 H-loop/switch region; other site 1087454001199 Htaa; Region: HtaA; pfam04213 1087454001200 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1087454001201 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1087454001202 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1087454001203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087454001204 putative substrate translocation pore; other site 1087454001205 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1087454001206 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1087454001207 putative catalytic site [active] 1087454001208 putative metal binding site [ion binding]; other site 1087454001209 putative phosphate binding site [ion binding]; other site 1087454001210 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1087454001211 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1087454001212 active site 1087454001213 HIGH motif; other site 1087454001214 dimer interface [polypeptide binding]; other site 1087454001215 KMSKS motif; other site 1087454001216 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1087454001217 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1087454001218 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1087454001219 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1087454001220 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1087454001221 active site 1087454001222 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1087454001223 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1087454001224 non-specific DNA binding site [nucleotide binding]; other site 1087454001225 salt bridge; other site 1087454001226 sequence-specific DNA binding site [nucleotide binding]; other site 1087454001227 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1087454001228 active site 1087454001229 substrate binding site [chemical binding]; other site 1087454001230 metal binding site [ion binding]; metal-binding site 1087454001231 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1087454001232 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1087454001233 metal binding site [ion binding]; metal-binding site 1087454001234 putative dimer interface [polypeptide binding]; other site 1087454001235 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1087454001236 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1087454001237 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1087454001238 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1087454001239 pyruvate carboxylase; Reviewed; Region: PRK12999 1087454001240 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1087454001241 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1087454001242 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1087454001243 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1087454001244 active site 1087454001245 catalytic residues [active] 1087454001246 metal binding site [ion binding]; metal-binding site 1087454001247 homodimer binding site [polypeptide binding]; other site 1087454001248 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1087454001249 carboxyltransferase (CT) interaction site; other site 1087454001250 biotinylation site [posttranslational modification]; other site 1087454001251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087454001252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087454001253 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1087454001254 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1087454001255 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1087454001256 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1087454001257 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1087454001258 carboxyltransferase (CT) interaction site; other site 1087454001259 biotinylation site [posttranslational modification]; other site 1087454001260 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1087454001261 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1087454001262 active site residue [active] 1087454001263 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1087454001264 active site residue [active] 1087454001265 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1087454001266 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1087454001267 Maf-like protein; Region: Maf; pfam02545 1087454001268 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1087454001269 active site 1087454001270 dimer interface [polypeptide binding]; other site 1087454001271 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1087454001272 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1087454001273 substrate binding site [chemical binding]; other site 1087454001274 ATP binding site [chemical binding]; other site 1087454001275 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1087454001276 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1087454001277 DNA binding site [nucleotide binding] 1087454001278 domain linker motif; other site 1087454001279 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 1087454001280 putative ligand binding site [chemical binding]; other site 1087454001281 dimerization interface [polypeptide binding]; other site 1087454001282 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1087454001283 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1087454001284 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1087454001285 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1087454001286 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1087454001287 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1087454001288 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1087454001289 ATP-grasp domain; Region: ATP-grasp; pfam02222 1087454001290 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1087454001291 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1087454001292 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1087454001293 putative active site [active] 1087454001294 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1087454001295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087454001296 dimer interface [polypeptide binding]; other site 1087454001297 conserved gate region; other site 1087454001298 ABC-ATPase subunit interface; other site 1087454001299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087454001300 dimer interface [polypeptide binding]; other site 1087454001301 conserved gate region; other site 1087454001302 putative PBP binding loops; other site 1087454001303 ABC-ATPase subunit interface; other site 1087454001304 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1087454001305 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1087454001306 TIGR03089 family protein; Region: TIGR03089 1087454001307 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1087454001308 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1087454001309 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1087454001310 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1087454001311 Probable Catalytic site; other site 1087454001312 metal-binding site 1087454001313 Transcription factor WhiB; Region: Whib; pfam02467 1087454001314 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1087454001315 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1087454001316 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1087454001317 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1087454001318 active site 1087454001319 substrate binding site [chemical binding]; other site 1087454001320 metal binding site [ion binding]; metal-binding site 1087454001321 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1087454001322 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 1087454001323 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1087454001324 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1087454001325 homotetramer interface [polypeptide binding]; other site 1087454001326 ligand binding site [chemical binding]; other site 1087454001327 catalytic site [active] 1087454001328 NAD binding site [chemical binding]; other site 1087454001329 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1087454001330 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1087454001331 TMP-binding site; other site 1087454001332 ATP-binding site [chemical binding]; other site 1087454001333 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1087454001334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1087454001335 active site 1087454001336 phosphorylation site [posttranslational modification] 1087454001337 intermolecular recognition site; other site 1087454001338 dimerization interface [polypeptide binding]; other site 1087454001339 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1087454001340 DNA binding site [nucleotide binding] 1087454001341 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1087454001342 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1087454001343 dimerization interface [polypeptide binding]; other site 1087454001344 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1087454001345 dimer interface [polypeptide binding]; other site 1087454001346 phosphorylation site [posttranslational modification] 1087454001347 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1087454001348 ATP binding site [chemical binding]; other site 1087454001349 Mg2+ binding site [ion binding]; other site 1087454001350 G-X-G motif; other site 1087454001351 lipoprotein LpqB; Provisional; Region: PRK13616 1087454001352 Sporulation and spore germination; Region: Germane; pfam10646 1087454001353 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1087454001354 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1087454001355 active site 1087454001356 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1087454001357 30S subunit binding site; other site 1087454001358 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1087454001359 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1087454001360 ATP binding site [chemical binding]; other site 1087454001361 putative Mg++ binding site [ion binding]; other site 1087454001362 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1087454001363 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1087454001364 nucleotide binding region [chemical binding]; other site 1087454001365 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1087454001366 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 1087454001367 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1087454001368 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1087454001369 FAD binding pocket [chemical binding]; other site 1087454001370 FAD binding motif [chemical binding]; other site 1087454001371 phosphate binding motif [ion binding]; other site 1087454001372 beta-alpha-beta structure motif; other site 1087454001373 NAD binding pocket [chemical binding]; other site 1087454001374 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1087454001375 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1087454001376 catalytic loop [active] 1087454001377 iron binding site [ion binding]; other site 1087454001378 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1087454001379 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1087454001380 putative di-iron ligands [ion binding]; other site 1087454001381 Predicted GTPases [General function prediction only]; Region: COG1162 1087454001382 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1087454001383 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1087454001384 GTP/Mg2+ binding site [chemical binding]; other site 1087454001385 G4 box; other site 1087454001386 G5 box; other site 1087454001387 G1 box; other site 1087454001388 Switch I region; other site 1087454001389 G2 box; other site 1087454001390 G3 box; other site 1087454001391 Switch II region; other site 1087454001392 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1087454001393 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1087454001394 hinge; other site 1087454001395 active site 1087454001396 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1087454001397 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1087454001398 putative deacylase active site [active] 1087454001399 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1087454001400 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1087454001401 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1087454001402 DNA binding residues [nucleotide binding] 1087454001403 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 1087454001404 Transcription factor WhiB; Region: Whib; pfam02467 1087454001405 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1087454001406 active site 1087454001407 catalytic triad [active] 1087454001408 oxyanion hole [active] 1087454001409 PQQ-like domain; Region: PQQ_2; pfam13360 1087454001410 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1087454001411 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1087454001412 ATP binding site [chemical binding]; other site 1087454001413 Mg++ binding site [ion binding]; other site 1087454001414 motif III; other site 1087454001415 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1087454001416 nucleotide binding region [chemical binding]; other site 1087454001417 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1087454001418 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1087454001419 TIGR02569 family protein; Region: TIGR02569_actnb 1087454001420 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1087454001421 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1087454001422 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1087454001423 Part of AAA domain; Region: AAA_19; pfam13245 1087454001424 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1087454001425 Ion channel; Region: Ion_trans_2; pfam07885 1087454001426 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1087454001427 TrkA-N domain; Region: TrkA_N; pfam02254 1087454001428 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1087454001429 putative NADH binding site [chemical binding]; other site 1087454001430 putative active site [active] 1087454001431 nudix motif; other site 1087454001432 putative metal binding site [ion binding]; other site 1087454001433 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1087454001434 Part of AAA domain; Region: AAA_19; pfam13245 1087454001435 Family description; Region: UvrD_C_2; pfam13538 1087454001436 HRDC domain; Region: HRDC; pfam00570 1087454001437 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 1087454001438 Protein of unknown function DUF45; Region: DUF45; cl00636 1087454001439 putative hydrolase; Region: TIGR03624 1087454001440 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1087454001441 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1087454001442 hypothetical protein; Validated; Region: PRK00068 1087454001443 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 1087454001444 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 1087454001445 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1087454001446 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 1087454001447 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1087454001448 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1087454001449 Predicted membrane protein [Function unknown]; Region: COG2311 1087454001450 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 1087454001451 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1087454001452 oxaloacetate decarboxylase; Provisional; Region: PRK12330 1087454001453 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1087454001454 active site 1087454001455 catalytic residues [active] 1087454001456 metal binding site [ion binding]; metal-binding site 1087454001457 homodimer binding site [polypeptide binding]; other site 1087454001458 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 1087454001459 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1087454001460 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1087454001461 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1087454001462 carboxyltransferase (CT) interaction site; other site 1087454001463 biotinylation site [posttranslational modification]; other site 1087454001464 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1087454001465 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1087454001466 active site 1087454001467 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1087454001468 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1087454001469 active site 1087454001470 topology modulation protein; Provisional; Region: PRK07261 1087454001471 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 1087454001472 active site 1087454001473 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 1087454001474 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 1087454001475 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1087454001476 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1087454001477 Walker A/P-loop; other site 1087454001478 ATP binding site [chemical binding]; other site 1087454001479 Q-loop/lid; other site 1087454001480 ABC transporter signature motif; other site 1087454001481 Walker B; other site 1087454001482 D-loop; other site 1087454001483 H-loop/switch region; other site 1087454001484 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1087454001485 FtsX-like permease family; Region: FtsX; pfam02687 1087454001486 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1087454001487 SmpB-tmRNA interface; other site 1087454001488 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1087454001489 active site clefts [active] 1087454001490 zinc binding site [ion binding]; other site 1087454001491 dimer interface [polypeptide binding]; other site 1087454001492 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1087454001493 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1087454001494 intersubunit interface [polypeptide binding]; other site 1087454001495 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1087454001496 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1087454001497 ABC-ATPase subunit interface; other site 1087454001498 dimer interface [polypeptide binding]; other site 1087454001499 putative PBP binding regions; other site 1087454001500 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1087454001501 ABC-ATPase subunit interface; other site 1087454001502 dimer interface [polypeptide binding]; other site 1087454001503 putative PBP binding regions; other site 1087454001504 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1087454001505 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1087454001506 Walker A/P-loop; other site 1087454001507 ATP binding site [chemical binding]; other site 1087454001508 Q-loop/lid; other site 1087454001509 ABC transporter signature motif; other site 1087454001510 Walker B; other site 1087454001511 D-loop; other site 1087454001512 H-loop/switch region; other site 1087454001513 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1087454001514 catalytic residue [active] 1087454001515 homodimer interface [polypeptide binding]; other site 1087454001516 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1087454001517 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1087454001518 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 1087454001519 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1087454001520 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1087454001521 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1087454001522 ATP binding site [chemical binding]; other site 1087454001523 putative Mg++ binding site [ion binding]; other site 1087454001524 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1087454001525 nucleotide binding region [chemical binding]; other site 1087454001526 ATP-binding site [chemical binding]; other site 1087454001527 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1087454001528 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1087454001529 Protein of unknown function (DUF3235); Region: DUF3235; pfam11574 1087454001530 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1087454001531 DNA-binding site [nucleotide binding]; DNA binding site 1087454001532 RNA-binding motif; other site 1087454001533 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 1087454001534 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1087454001535 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1087454001536 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1087454001537 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1087454001538 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1087454001539 catalytic residue [active] 1087454001540 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1087454001541 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1087454001542 dimer interface [polypeptide binding]; other site 1087454001543 active site 1087454001544 citrylCoA binding site [chemical binding]; other site 1087454001545 NADH binding [chemical binding]; other site 1087454001546 cationic pore residues; other site 1087454001547 oxalacetate/citrate binding site [chemical binding]; other site 1087454001548 coenzyme A binding site [chemical binding]; other site 1087454001549 catalytic triad [active] 1087454001550 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1087454001551 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 1087454001552 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1087454001553 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1087454001554 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1087454001555 E-class dimer interface [polypeptide binding]; other site 1087454001556 P-class dimer interface [polypeptide binding]; other site 1087454001557 active site 1087454001558 Cu2+ binding site [ion binding]; other site 1087454001559 Zn2+ binding site [ion binding]; other site 1087454001560 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1087454001561 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1087454001562 active site 1087454001563 catalytic tetrad [active] 1087454001564 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1087454001565 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1087454001566 substrate binding site [chemical binding]; other site 1087454001567 oxyanion hole (OAH) forming residues; other site 1087454001568 trimer interface [polypeptide binding]; other site 1087454001569 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1087454001570 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1087454001571 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1087454001572 Na binding site [ion binding]; other site 1087454001573 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1087454001574 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1087454001575 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1087454001576 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 1087454001577 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 1087454001578 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1087454001579 multidrug efflux protein NorA; Provisional; Region: PRK00187 1087454001580 cation binding site [ion binding]; other site 1087454001581 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1087454001582 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1087454001583 dimer interface [polypeptide binding]; other site 1087454001584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1087454001585 catalytic residue [active] 1087454001586 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1087454001587 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1087454001588 catalytic residue [active] 1087454001589 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1087454001590 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1087454001591 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1087454001592 substrate binding pocket [chemical binding]; other site 1087454001593 active site 1087454001594 iron coordination sites [ion binding]; other site 1087454001595 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 1087454001596 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1087454001597 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1087454001598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087454001599 dimer interface [polypeptide binding]; other site 1087454001600 conserved gate region; other site 1087454001601 putative PBP binding loops; other site 1087454001602 ABC-ATPase subunit interface; other site 1087454001603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1087454001604 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1087454001605 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1087454001606 Walker A/P-loop; other site 1087454001607 ATP binding site [chemical binding]; other site 1087454001608 Q-loop/lid; other site 1087454001609 ABC transporter signature motif; other site 1087454001610 Walker B; other site 1087454001611 D-loop; other site 1087454001612 H-loop/switch region; other site 1087454001613 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1087454001614 Walker A/P-loop; other site 1087454001615 ATP binding site [chemical binding]; other site 1087454001616 Q-loop/lid; other site 1087454001617 ABC transporter signature motif; other site 1087454001618 Walker B; other site 1087454001619 D-loop; other site 1087454001620 H-loop/switch region; other site 1087454001621 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1087454001622 active site 1087454001623 SAM binding site [chemical binding]; other site 1087454001624 homodimer interface [polypeptide binding]; other site 1087454001625 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1087454001626 catalytic residues [active] 1087454001627 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1087454001628 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1087454001629 dimerization interface [polypeptide binding]; other site 1087454001630 active site 1087454001631 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1087454001632 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1087454001633 active site 1087454001634 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1087454001635 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1087454001636 ATP binding site [chemical binding]; other site 1087454001637 putative Mg++ binding site [ion binding]; other site 1087454001638 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1087454001639 nucleotide binding region [chemical binding]; other site 1087454001640 ATP-binding site [chemical binding]; other site 1087454001641 DEAD/H associated; Region: DEAD_assoc; pfam08494 1087454001642 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1087454001643 active site 1087454001644 SUMO-1 interface [polypeptide binding]; other site 1087454001645 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1087454001646 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1087454001647 putative DNA binding site [nucleotide binding]; other site 1087454001648 catalytic residue [active] 1087454001649 putative H2TH interface [polypeptide binding]; other site 1087454001650 putative catalytic residues [active] 1087454001651 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1087454001652 hypothetical protein; Provisional; Region: PRK11770 1087454001653 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1087454001654 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1087454001655 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1087454001656 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1087454001657 active site 1087454001658 dimer interface [polypeptide binding]; other site 1087454001659 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1087454001660 dimer interface [polypeptide binding]; other site 1087454001661 active site 1087454001662 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1087454001663 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1087454001664 tetramerization interface [polypeptide binding]; other site 1087454001665 NAD(P) binding site [chemical binding]; other site 1087454001666 catalytic residues [active] 1087454001667 hypothetical protein; Provisional; Region: PRK07857 1087454001668 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1087454001669 Part of AAA domain; Region: AAA_19; pfam13245 1087454001670 Family description; Region: UvrD_C_2; pfam13538 1087454001671 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1087454001672 Peptidase family M23; Region: Peptidase_M23; pfam01551 1087454001673 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 1087454001674 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1087454001675 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1087454001676 active site 1087454001677 substrate binding site [chemical binding]; other site 1087454001678 cosubstrate binding site; other site 1087454001679 catalytic site [active] 1087454001680 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1087454001681 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1087454001682 purine monophosphate binding site [chemical binding]; other site 1087454001683 dimer interface [polypeptide binding]; other site 1087454001684 putative catalytic residues [active] 1087454001685 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1087454001686 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1087454001687 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1087454001688 Walker A/P-loop; other site 1087454001689 ATP binding site [chemical binding]; other site 1087454001690 Q-loop/lid; other site 1087454001691 ABC transporter signature motif; other site 1087454001692 Walker B; other site 1087454001693 D-loop; other site 1087454001694 H-loop/switch region; other site 1087454001695 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1087454001696 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1087454001697 substrate binding pocket [chemical binding]; other site 1087454001698 membrane-bound complex binding site; other site 1087454001699 hinge residues; other site 1087454001700 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1087454001701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087454001702 dimer interface [polypeptide binding]; other site 1087454001703 conserved gate region; other site 1087454001704 putative PBP binding loops; other site 1087454001705 ABC-ATPase subunit interface; other site 1087454001706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087454001707 dimer interface [polypeptide binding]; other site 1087454001708 conserved gate region; other site 1087454001709 putative PBP binding loops; other site 1087454001710 ABC-ATPase subunit interface; other site 1087454001711 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1087454001712 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1087454001713 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1087454001714 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 1087454001715 30S ribosomal protein S18; Provisional; Region: PRK13401 1087454001716 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1087454001717 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1087454001718 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1087454001719 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1087454001720 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1087454001721 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1087454001722 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1087454001723 active site 1087454001724 phosphorylation site [posttranslational modification] 1087454001725 intermolecular recognition site; other site 1087454001726 dimerization interface [polypeptide binding]; other site 1087454001727 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1087454001728 DNA binding site [nucleotide binding] 1087454001729 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1087454001730 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1087454001731 dimerization interface [polypeptide binding]; other site 1087454001732 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1087454001733 dimer interface [polypeptide binding]; other site 1087454001734 phosphorylation site [posttranslational modification] 1087454001735 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1087454001736 ATP binding site [chemical binding]; other site 1087454001737 Mg2+ binding site [ion binding]; other site 1087454001738 G-X-G motif; other site 1087454001739 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1087454001740 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1087454001741 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1087454001742 protein binding site [polypeptide binding]; other site 1087454001743 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1087454001744 MPT binding site; other site 1087454001745 trimer interface [polypeptide binding]; other site 1087454001746 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1087454001747 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1087454001748 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1087454001749 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1087454001750 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1087454001751 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 1087454001752 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1087454001753 active site 1087454001754 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1087454001755 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1087454001756 dimer interface [polypeptide binding]; other site 1087454001757 putative functional site; other site 1087454001758 putative MPT binding site; other site 1087454001759 Predicted membrane protein [Function unknown]; Region: COG2259 1087454001760 Predicted integral membrane protein [Function unknown]; Region: COG5660 1087454001761 Putative zinc-finger; Region: zf-HC2; pfam13490 1087454001762 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1087454001763 BCCT family transporter; Region: BCCT; pfam02028 1087454001764 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1087454001765 Predicted methyltransferases [General function prediction only]; Region: COG0313 1087454001766 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1087454001767 putative SAM binding site [chemical binding]; other site 1087454001768 putative homodimer interface [polypeptide binding]; other site 1087454001769 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1087454001770 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1087454001771 active site 1087454001772 HIGH motif; other site 1087454001773 KMSKS motif; other site 1087454001774 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1087454001775 tRNA binding surface [nucleotide binding]; other site 1087454001776 anticodon binding site; other site 1087454001777 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1087454001778 active site 1087454001779 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1087454001780 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1087454001781 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1087454001782 G5 domain; Region: G5; pfam07501 1087454001783 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1087454001784 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1087454001785 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1087454001786 S-adenosylmethionine binding site [chemical binding]; other site 1087454001787 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1087454001788 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1087454001789 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1087454001790 ABC transporter; Region: ABC_tran_2; pfam12848 1087454001791 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1087454001792 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1087454001793 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1087454001794 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 1087454001795 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 1087454001796 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1087454001797 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1087454001798 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1087454001799 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1087454001800 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 1087454001801 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1087454001802 G1 box; other site 1087454001803 putative GEF interaction site [polypeptide binding]; other site 1087454001804 GTP/Mg2+ binding site [chemical binding]; other site 1087454001805 Switch I region; other site 1087454001806 G2 box; other site 1087454001807 G3 box; other site 1087454001808 Switch II region; other site 1087454001809 G4 box; other site 1087454001810 G5 box; other site 1087454001811 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1087454001812 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1087454001813 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 1087454001814 NAD(P) binding site [chemical binding]; other site 1087454001815 active site 1087454001816 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1087454001817 putative active site [active] 1087454001818 catalytic residue [active] 1087454001819 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1087454001820 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1087454001821 FMN binding site [chemical binding]; other site 1087454001822 substrate binding site [chemical binding]; other site 1087454001823 putative catalytic residue [active] 1087454001824 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1087454001825 putative active site [active] 1087454001826 catalytic residue [active] 1087454001827 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1087454001828 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1087454001829 5S rRNA interface [nucleotide binding]; other site 1087454001830 CTC domain interface [polypeptide binding]; other site 1087454001831 L16 interface [polypeptide binding]; other site 1087454001832 pullulanase, type I; Region: pulA_typeI; TIGR02104 1087454001833 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1087454001834 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1087454001835 Ca binding site [ion binding]; other site 1087454001836 active site 1087454001837 catalytic site [active] 1087454001838 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1087454001839 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1087454001840 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1087454001841 active site 1087454001842 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1087454001843 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1087454001844 Substrate binding site; other site 1087454001845 Mg++ binding site; other site 1087454001846 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1087454001847 active site 1087454001848 substrate binding site [chemical binding]; other site 1087454001849 CoA binding site [chemical binding]; other site 1087454001850 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 1087454001851 gating phenylalanine in ion channel; other site 1087454001852 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1087454001853 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1087454001854 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1087454001855 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1087454001856 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1087454001857 ATP binding site [chemical binding]; other site 1087454001858 putative Mg++ binding site [ion binding]; other site 1087454001859 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1087454001860 nucleotide binding region [chemical binding]; other site 1087454001861 ATP-binding site [chemical binding]; other site 1087454001862 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1087454001863 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1087454001864 Spore germination protein; Region: Spore_permease; cl17796 1087454001865 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1087454001866 homodimer interface [polypeptide binding]; other site 1087454001867 metal binding site [ion binding]; metal-binding site 1087454001868 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1087454001869 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1087454001870 enolase; Provisional; Region: eno; PRK00077 1087454001871 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1087454001872 dimer interface [polypeptide binding]; other site 1087454001873 metal binding site [ion binding]; metal-binding site 1087454001874 substrate binding pocket [chemical binding]; other site 1087454001875 Septum formation initiator; Region: DivIC; pfam04977 1087454001876 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1087454001877 Uncharacterized conserved protein [Function unknown]; Region: COG1507 1087454001878 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1087454001879 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1087454001880 Helix-turn-helix domain; Region: HTH_18; pfam12833 1087454001881 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1087454001882 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1087454001883 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1087454001884 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1087454001885 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1087454001886 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1087454001887 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 1087454001888 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1087454001889 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1087454001890 catalytic residue [active] 1087454001891 putative FPP diphosphate binding site; other site 1087454001892 putative FPP binding hydrophobic cleft; other site 1087454001893 dimer interface [polypeptide binding]; other site 1087454001894 putative IPP diphosphate binding site; other site 1087454001895 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 1087454001896 pantothenate kinase; Provisional; Region: PRK05439 1087454001897 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1087454001898 ATP-binding site [chemical binding]; other site 1087454001899 CoA-binding site [chemical binding]; other site 1087454001900 Mg2+-binding site [ion binding]; other site 1087454001901 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1087454001902 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1087454001903 dimer interface [polypeptide binding]; other site 1087454001904 active site 1087454001905 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1087454001906 folate binding site [chemical binding]; other site 1087454001907 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1087454001908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087454001909 putative substrate translocation pore; other site 1087454001910 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1087454001911 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1087454001912 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1087454001913 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1087454001914 dimerization interface [polypeptide binding]; other site 1087454001915 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1087454001916 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1087454001917 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1087454001918 Coenzyme A binding pocket [chemical binding]; other site 1087454001919 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087454001920 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1087454001921 putative substrate translocation pore; other site 1087454001922 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087454001923 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1087454001924 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1087454001925 Class II fumarases; Region: Fumarase_classII; cd01362 1087454001926 active site 1087454001927 tetramer interface [polypeptide binding]; other site 1087454001928 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1087454001929 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1087454001930 putative active site [active] 1087454001931 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1087454001932 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1087454001933 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1087454001934 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1087454001935 generic binding surface II; other site 1087454001936 generic binding surface I; other site 1087454001937 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1087454001938 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1087454001939 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1087454001940 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1087454001941 GTP-binding protein YchF; Reviewed; Region: PRK09601 1087454001942 YchF GTPase; Region: YchF; cd01900 1087454001943 G1 box; other site 1087454001944 GTP/Mg2+ binding site [chemical binding]; other site 1087454001945 Switch I region; other site 1087454001946 G2 box; other site 1087454001947 Switch II region; other site 1087454001948 G3 box; other site 1087454001949 G4 box; other site 1087454001950 G5 box; other site 1087454001951 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1087454001952 Protein of unknown function, DUF488; Region: DUF488; pfam04343 1087454001953 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1087454001954 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1087454001955 PhnA protein; Region: PhnA; pfam03831 1087454001956 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1087454001957 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1087454001958 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1087454001959 Walker A/P-loop; other site 1087454001960 ATP binding site [chemical binding]; other site 1087454001961 Q-loop/lid; other site 1087454001962 ABC transporter signature motif; other site 1087454001963 Walker B; other site 1087454001964 D-loop; other site 1087454001965 H-loop/switch region; other site 1087454001966 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1087454001967 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1087454001968 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1087454001969 Walker A/P-loop; other site 1087454001970 ATP binding site [chemical binding]; other site 1087454001971 Q-loop/lid; other site 1087454001972 ABC transporter signature motif; other site 1087454001973 Walker B; other site 1087454001974 D-loop; other site 1087454001975 H-loop/switch region; other site 1087454001976 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 1087454001977 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1087454001978 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1087454001979 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1087454001980 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 1087454001981 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1087454001982 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1087454001983 Walker A/P-loop; other site 1087454001984 ATP binding site [chemical binding]; other site 1087454001985 Q-loop/lid; other site 1087454001986 ABC transporter signature motif; other site 1087454001987 Walker B; other site 1087454001988 D-loop; other site 1087454001989 H-loop/switch region; other site 1087454001990 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1087454001991 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1087454001992 Walker A/P-loop; other site 1087454001993 ATP binding site [chemical binding]; other site 1087454001994 Q-loop/lid; other site 1087454001995 ABC transporter signature motif; other site 1087454001996 Walker B; other site 1087454001997 D-loop; other site 1087454001998 H-loop/switch region; other site 1087454001999 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1087454002000 hypothetical protein; Provisional; Region: PRK06547 1087454002001 AAA domain; Region: AAA_18; pfam13238 1087454002002 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1087454002003 nudix motif; other site 1087454002004 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1087454002005 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1087454002006 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1087454002007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087454002008 dimer interface [polypeptide binding]; other site 1087454002009 conserved gate region; other site 1087454002010 ABC-ATPase subunit interface; other site 1087454002011 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1087454002012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087454002013 dimer interface [polypeptide binding]; other site 1087454002014 conserved gate region; other site 1087454002015 putative PBP binding loops; other site 1087454002016 ABC-ATPase subunit interface; other site 1087454002017 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1087454002018 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1087454002019 Walker A/P-loop; other site 1087454002020 ATP binding site [chemical binding]; other site 1087454002021 Q-loop/lid; other site 1087454002022 ABC transporter signature motif; other site 1087454002023 Walker B; other site 1087454002024 D-loop; other site 1087454002025 H-loop/switch region; other site 1087454002026 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1087454002027 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1087454002028 Walker A/P-loop; other site 1087454002029 ATP binding site [chemical binding]; other site 1087454002030 Q-loop/lid; other site 1087454002031 ABC transporter signature motif; other site 1087454002032 Walker B; other site 1087454002033 D-loop; other site 1087454002034 H-loop/switch region; other site 1087454002035 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1087454002036 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1087454002037 cleavage site 1087454002038 active site 1087454002039 substrate binding sites [chemical binding]; other site 1087454002040 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1087454002041 ArsC family; Region: ArsC; pfam03960 1087454002042 catalytic residues [active] 1087454002043 Protein of unknown function (DUF402); Region: DUF402; cl00979 1087454002044 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1087454002045 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1087454002046 G1 box; other site 1087454002047 GTP/Mg2+ binding site [chemical binding]; other site 1087454002048 G2 box; other site 1087454002049 Switch I region; other site 1087454002050 G3 box; other site 1087454002051 Switch II region; other site 1087454002052 G4 box; other site 1087454002053 G5 box; other site 1087454002054 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1087454002055 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1087454002056 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1087454002057 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1087454002058 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1087454002059 Ferredoxin [Energy production and conversion]; Region: COG1146 1087454002060 4Fe-4S binding domain; Region: Fer4; pfam00037 1087454002061 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1087454002062 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1087454002063 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1087454002064 homodimer interface [polypeptide binding]; other site 1087454002065 catalytic residue [active] 1087454002066 Predicted membrane protein [Function unknown]; Region: COG2246 1087454002067 GtrA-like protein; Region: GtrA; pfam04138 1087454002068 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1087454002069 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1087454002070 active site 1087454002071 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1087454002072 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1087454002073 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1087454002074 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1087454002075 putative trimer interface [polypeptide binding]; other site 1087454002076 putative CoA binding site [chemical binding]; other site 1087454002077 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1087454002078 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1087454002079 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1087454002080 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1087454002081 putative trimer interface [polypeptide binding]; other site 1087454002082 putative CoA binding site [chemical binding]; other site 1087454002083 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1087454002084 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1087454002085 metal binding site [ion binding]; metal-binding site 1087454002086 putative dimer interface [polypeptide binding]; other site 1087454002087 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1087454002088 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1087454002089 dihydropteroate synthase; Region: DHPS; TIGR01496 1087454002090 substrate binding pocket [chemical binding]; other site 1087454002091 dimer interface [polypeptide binding]; other site 1087454002092 inhibitor binding site; inhibition site 1087454002093 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1087454002094 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1087454002095 Ligand binding site; other site 1087454002096 Putative Catalytic site; other site 1087454002097 DXD motif; other site 1087454002098 DivIVA domain; Region: DivI1A_domain; TIGR03544 1087454002099 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1087454002100 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1087454002101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1087454002102 S-adenosylmethionine binding site [chemical binding]; other site 1087454002103 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 1087454002104 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1087454002105 active site 1087454002106 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1087454002107 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 1087454002108 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1087454002109 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1087454002110 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1087454002111 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1087454002112 ligand binding site; other site 1087454002113 oligomer interface; other site 1087454002114 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1087454002115 dimer interface [polypeptide binding]; other site 1087454002116 N-terminal domain interface [polypeptide binding]; other site 1087454002117 sulfate 1 binding site; other site 1087454002118 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1087454002119 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 1087454002120 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1087454002121 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1087454002122 DNA binding residues [nucleotide binding] 1087454002123 sec-independent translocase; Provisional; Region: tatB; PRK00182 1087454002124 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1087454002125 Domain of unknown function DUF59; Region: DUF59; pfam01883 1087454002126 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1087454002127 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1087454002128 Predicted membrane protein [Function unknown]; Region: COG4420 1087454002129 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1087454002130 MgtE intracellular N domain; Region: MgtE_N; smart00924 1087454002131 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1087454002132 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1087454002133 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1087454002134 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1087454002135 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1087454002136 TPP-binding site [chemical binding]; other site 1087454002137 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1087454002138 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1087454002139 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1087454002140 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1087454002141 Walker A/P-loop; other site 1087454002142 ATP binding site [chemical binding]; other site 1087454002143 Q-loop/lid; other site 1087454002144 ABC transporter signature motif; other site 1087454002145 Walker B; other site 1087454002146 D-loop; other site 1087454002147 H-loop/switch region; other site 1087454002148 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1087454002149 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1087454002150 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1087454002151 Walker A/P-loop; other site 1087454002152 ATP binding site [chemical binding]; other site 1087454002153 Q-loop/lid; other site 1087454002154 ABC transporter signature motif; other site 1087454002155 Walker B; other site 1087454002156 D-loop; other site 1087454002157 H-loop/switch region; other site 1087454002158 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 1087454002159 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1087454002160 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1087454002161 shikimate binding site; other site 1087454002162 NAD(P) binding site [chemical binding]; other site 1087454002163 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1087454002164 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1087454002165 substrate binding pocket [chemical binding]; other site 1087454002166 catalytic triad [active] 1087454002167 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 1087454002168 active site 1087454002169 catalytic residues [active] 1087454002170 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 1087454002171 putative transporter; Provisional; Region: PRK10484 1087454002172 Na binding site [ion binding]; other site 1087454002173 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1087454002174 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1087454002175 nucleotide binding site/active site [active] 1087454002176 HIT family signature motif; other site 1087454002177 catalytic residue [active] 1087454002178 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1087454002179 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1087454002180 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1087454002181 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1087454002182 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1087454002183 ATP binding site [chemical binding]; other site 1087454002184 Mg++ binding site [ion binding]; other site 1087454002185 motif III; other site 1087454002186 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1087454002187 nucleotide binding region [chemical binding]; other site 1087454002188 ATP-binding site [chemical binding]; other site 1087454002189 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1087454002190 putative RNA binding site [nucleotide binding]; other site 1087454002191 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1087454002192 dimer interface [polypeptide binding]; other site 1087454002193 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1087454002194 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1087454002195 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1087454002196 Na binding site [ion binding]; other site 1087454002197 SNF2 Helicase protein; Region: DUF3670; pfam12419 1087454002198 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1087454002199 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1087454002200 ATP binding site [chemical binding]; other site 1087454002201 putative Mg++ binding site [ion binding]; other site 1087454002202 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1087454002203 nucleotide binding region [chemical binding]; other site 1087454002204 ATP-binding site [chemical binding]; other site 1087454002205 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1087454002206 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1087454002207 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1087454002208 active site 1087454002209 metal binding site [ion binding]; metal-binding site 1087454002210 DNA binding site [nucleotide binding] 1087454002211 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 1087454002212 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1087454002213 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1087454002214 MarR family; Region: MarR_2; pfam12802 1087454002215 PspC domain; Region: PspC; pfam04024 1087454002216 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1087454002217 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1087454002218 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1087454002219 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1087454002220 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1087454002221 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1087454002222 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1087454002223 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1087454002224 Cysteine-rich domain; Region: CCG; pfam02754 1087454002225 Cysteine-rich domain; Region: CCG; pfam02754 1087454002226 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1087454002227 L-lactate permease; Region: Lactate_perm; cl00701 1087454002228 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1087454002229 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1087454002230 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1087454002231 active site 1087454002232 HIGH motif; other site 1087454002233 KMSK motif region; other site 1087454002234 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1087454002235 tRNA binding surface [nucleotide binding]; other site 1087454002236 anticodon binding site; other site 1087454002237 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1087454002238 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1087454002239 active site 1087454002240 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1087454002241 substrate binding site [chemical binding]; other site 1087454002242 catalytic residues [active] 1087454002243 dimer interface [polypeptide binding]; other site 1087454002244 homoserine dehydrogenase; Provisional; Region: PRK06349 1087454002245 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1087454002246 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1087454002247 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1087454002248 homoserine kinase; Provisional; Region: PRK01212 1087454002249 Predicted transcriptional regulator [Transcription]; Region: COG2345 1087454002250 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 1087454002251 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620 1087454002252 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1087454002253 acyl-activating enzyme (AAE) consensus motif; other site 1087454002254 AMP binding site [chemical binding]; other site 1087454002255 active site 1087454002256 CoA binding site [chemical binding]; other site 1087454002257 transcription termination factor Rho; Provisional; Region: PRK12678 1087454002258 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1087454002259 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1087454002260 RNA binding site [nucleotide binding]; other site 1087454002261 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1087454002262 multimer interface [polypeptide binding]; other site 1087454002263 Walker A motif; other site 1087454002264 ATP binding site [chemical binding]; other site 1087454002265 Walker B motif; other site 1087454002266 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1087454002267 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1087454002268 RF-1 domain; Region: RF-1; pfam00472 1087454002269 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1087454002270 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1087454002271 S-adenosylmethionine binding site [chemical binding]; other site 1087454002272 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1087454002273 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1087454002274 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1087454002275 Mg++ binding site [ion binding]; other site 1087454002276 putative catalytic motif [active] 1087454002277 substrate binding site [chemical binding]; other site 1087454002278 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1087454002279 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1087454002280 F0F1 ATP synthase subunit C; Validated; Region: PRK07874 1087454002281 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1087454002282 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1087454002283 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1087454002284 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1087454002285 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1087454002286 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1087454002287 beta subunit interaction interface [polypeptide binding]; other site 1087454002288 Walker A motif; other site 1087454002289 ATP binding site [chemical binding]; other site 1087454002290 Walker B motif; other site 1087454002291 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1087454002292 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1087454002293 core domain interface [polypeptide binding]; other site 1087454002294 delta subunit interface [polypeptide binding]; other site 1087454002295 epsilon subunit interface [polypeptide binding]; other site 1087454002296 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1087454002297 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1087454002298 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1087454002299 alpha subunit interaction interface [polypeptide binding]; other site 1087454002300 Walker A motif; other site 1087454002301 ATP binding site [chemical binding]; other site 1087454002302 Walker B motif; other site 1087454002303 inhibitor binding site; inhibition site 1087454002304 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1087454002305 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1087454002306 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1087454002307 gamma subunit interface [polypeptide binding]; other site 1087454002308 epsilon subunit interface [polypeptide binding]; other site 1087454002309 LBP interface [polypeptide binding]; other site 1087454002310 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1087454002311 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1087454002312 hypothetical protein; Provisional; Region: PRK03298 1087454002313 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1087454002314 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1087454002315 dimer interface [polypeptide binding]; other site 1087454002316 substrate binding site [chemical binding]; other site 1087454002317 metal binding site [ion binding]; metal-binding site 1087454002318 Domain of unknown function DUF77; Region: DUF77; pfam01910 1087454002319 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1087454002320 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1087454002321 glycogen branching enzyme; Provisional; Region: PRK05402 1087454002322 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1087454002323 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1087454002324 active site 1087454002325 catalytic site [active] 1087454002326 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1087454002327 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1087454002328 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1087454002329 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1087454002330 active site 1087454002331 catalytic site [active] 1087454002332 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1087454002333 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1087454002334 Walker A/P-loop; other site 1087454002335 ATP binding site [chemical binding]; other site 1087454002336 ABC transporter signature motif; other site 1087454002337 Walker B; other site 1087454002338 D-loop; other site 1087454002339 H-loop/switch region; other site 1087454002340 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1087454002341 Ligand binding site [chemical binding]; other site 1087454002342 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1087454002343 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1087454002344 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1087454002345 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1087454002346 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1087454002347 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1087454002348 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1087454002349 catalytic residue [active] 1087454002350 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1087454002351 S-adenosylmethionine binding site [chemical binding]; other site 1087454002352 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1087454002353 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1087454002354 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1087454002355 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1087454002356 active site 1087454002357 catalytic site [active] 1087454002358 substrate binding site [chemical binding]; other site 1087454002359 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1087454002360 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1087454002361 nucleotide binding pocket [chemical binding]; other site 1087454002362 K-X-D-G motif; other site 1087454002363 catalytic site [active] 1087454002364 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1087454002365 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1087454002366 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1087454002367 Dimer interface [polypeptide binding]; other site 1087454002368 BRCT sequence motif; other site 1087454002369 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1087454002370 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1087454002371 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1087454002372 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1087454002373 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1087454002374 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1087454002375 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1087454002376 ABC-ATPase subunit interface; other site 1087454002377 dimer interface [polypeptide binding]; other site 1087454002378 putative PBP binding regions; other site 1087454002379 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1087454002380 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 1087454002381 Walker A/P-loop; other site 1087454002382 ATP binding site [chemical binding]; other site 1087454002383 Q-loop/lid; other site 1087454002384 ABC transporter signature motif; other site 1087454002385 Walker B; other site 1087454002386 D-loop; other site 1087454002387 H-loop/switch region; other site 1087454002388 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 1087454002389 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1087454002390 putative ligand binding residues [chemical binding]; other site 1087454002391 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1087454002392 phosphofructokinase; Region: PFK_mixed; TIGR02483 1087454002393 active site 1087454002394 ADP/pyrophosphate binding site [chemical binding]; other site 1087454002395 dimerization interface [polypeptide binding]; other site 1087454002396 allosteric effector site; other site 1087454002397 fructose-1,6-bisphosphate binding site; other site 1087454002398 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1087454002399 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1087454002400 GatB domain; Region: GatB_Yqey; smart00845 1087454002401 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1087454002402 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1087454002403 active site 1087454002404 catalytic tetrad [active] 1087454002405 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1087454002406 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1087454002407 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1087454002408 dimerization interface [polypeptide binding]; other site 1087454002409 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1087454002410 Predicted membrane protein [Function unknown]; Region: COG2259 1087454002411 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1087454002412 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1087454002413 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1087454002414 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1087454002415 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1087454002416 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1087454002417 putative valine binding site [chemical binding]; other site 1087454002418 dimer interface [polypeptide binding]; other site 1087454002419 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1087454002420 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1087454002421 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1087454002422 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1087454002423 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1087454002424 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1087454002425 Protein of unknown function DUF262; Region: DUF262; pfam03235 1087454002426 Uncharacterized conserved protein [Function unknown]; Region: COG3472 1087454002427 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1087454002428 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1087454002429 ligand binding site [chemical binding]; other site 1087454002430 NAD binding site [chemical binding]; other site 1087454002431 dimerization interface [polypeptide binding]; other site 1087454002432 catalytic site [active] 1087454002433 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1087454002434 putative L-serine binding site [chemical binding]; other site 1087454002435 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1087454002436 tartrate dehydrogenase; Region: TTC; TIGR02089 1087454002437 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1087454002438 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1087454002439 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1087454002440 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1087454002441 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1087454002442 active site 1087454002443 HIGH motif; other site 1087454002444 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1087454002445 active site 1087454002446 KMSKS motif; other site 1087454002447 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1087454002448 Cutinase; Region: Cutinase; pfam01083 1087454002449 biotin synthase; Region: bioB; TIGR00433 1087454002450 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1087454002451 FeS/SAM binding site; other site 1087454002452 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1087454002453 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1087454002454 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1087454002455 Zn2+ binding site [ion binding]; other site 1087454002456 Mg2+ binding site [ion binding]; other site 1087454002457 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1087454002458 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1087454002459 Bacterial transcriptional regulator; Region: IclR; pfam01614 1087454002460 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1087454002461 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1087454002462 substrate binding site [chemical binding]; other site 1087454002463 ligand binding site [chemical binding]; other site 1087454002464 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1087454002465 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1087454002466 substrate binding site [chemical binding]; other site 1087454002467 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1087454002468 active site 1087454002469 Ap6A binding site [chemical binding]; other site 1087454002470 nudix motif; other site 1087454002471 metal binding site [ion binding]; metal-binding site 1087454002472 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1087454002473 catalytic core [active] 1087454002474 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1087454002475 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1087454002476 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1087454002477 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1087454002478 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1087454002479 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1087454002480 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1087454002481 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1087454002482 thiamine monophosphate kinase; Provisional; Region: PRK05731 1087454002483 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1087454002484 ATP binding site [chemical binding]; other site 1087454002485 dimerization interface [polypeptide binding]; other site 1087454002486 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1087454002487 ligand binding site [chemical binding]; other site 1087454002488 active site 1087454002489 UGI interface [polypeptide binding]; other site 1087454002490 catalytic site [active] 1087454002491 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1087454002492 DAK2 domain; Region: Dak2; pfam02734 1087454002493 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1087454002494 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1087454002495 generic binding surface II; other site 1087454002496 ssDNA binding site; other site 1087454002497 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1087454002498 ATP binding site [chemical binding]; other site 1087454002499 putative Mg++ binding site [ion binding]; other site 1087454002500 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1087454002501 nucleotide binding region [chemical binding]; other site 1087454002502 ATP-binding site [chemical binding]; other site 1087454002503 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 1087454002504 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1087454002505 carboxyltransferase (CT) interaction site; other site 1087454002506 biotinylation site [posttranslational modification]; other site 1087454002507 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1087454002508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1087454002509 S-adenosylmethionine binding site [chemical binding]; other site 1087454002510 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1087454002511 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1087454002512 active site 1087454002513 (T/H)XGH motif; other site 1087454002514 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1087454002515 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1087454002516 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1087454002517 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1087454002518 Walker A/P-loop; other site 1087454002519 ATP binding site [chemical binding]; other site 1087454002520 Q-loop/lid; other site 1087454002521 ABC transporter signature motif; other site 1087454002522 Walker B; other site 1087454002523 D-loop; other site 1087454002524 H-loop/switch region; other site 1087454002525 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1087454002526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087454002527 dimer interface [polypeptide binding]; other site 1087454002528 conserved gate region; other site 1087454002529 putative PBP binding loops; other site 1087454002530 ABC-ATPase subunit interface; other site 1087454002531 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1087454002532 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1087454002533 substrate binding pocket [chemical binding]; other site 1087454002534 membrane-bound complex binding site; other site 1087454002535 hinge residues; other site 1087454002536 Domain of unknown function (DUF368); Region: DUF368; pfam04018 1087454002537 DNA polymerase I; Provisional; Region: PRK05755 1087454002538 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1087454002539 active site 1087454002540 metal binding site 1 [ion binding]; metal-binding site 1087454002541 putative 5' ssDNA interaction site; other site 1087454002542 metal binding site 3; metal-binding site 1087454002543 metal binding site 2 [ion binding]; metal-binding site 1087454002544 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1087454002545 putative DNA binding site [nucleotide binding]; other site 1087454002546 putative metal binding site [ion binding]; other site 1087454002547 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1087454002548 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1087454002549 active site 1087454002550 DNA binding site [nucleotide binding] 1087454002551 catalytic site [active] 1087454002552 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1087454002553 S-adenosylmethionine binding site [chemical binding]; other site 1087454002554 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1087454002555 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1087454002556 RNA binding site [nucleotide binding]; other site 1087454002557 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1087454002558 RNA binding site [nucleotide binding]; other site 1087454002559 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1087454002560 RNA binding site [nucleotide binding]; other site 1087454002561 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1087454002562 RNA binding site [nucleotide binding]; other site 1087454002563 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1087454002564 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1087454002565 active site turn [active] 1087454002566 phosphorylation site [posttranslational modification] 1087454002567 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1087454002568 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1087454002569 HPr interaction site; other site 1087454002570 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1087454002571 active site 1087454002572 phosphorylation site [posttranslational modification] 1087454002573 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1087454002574 ATP-binding [chemical binding]; other site 1087454002575 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1087454002576 CoA-binding site [chemical binding]; other site 1087454002577 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 1087454002578 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1087454002579 FeS/SAM binding site; other site 1087454002580 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1087454002581 excinuclease ABC subunit B; Provisional; Region: PRK05298 1087454002582 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1087454002583 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1087454002584 nucleotide binding region [chemical binding]; other site 1087454002585 ATP-binding site [chemical binding]; other site 1087454002586 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1087454002587 UvrB/uvrC motif; Region: UVR; pfam02151 1087454002588 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1087454002589 Ligand Binding Site [chemical binding]; other site 1087454002590 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1087454002591 Part of AAA domain; Region: AAA_19; pfam13245 1087454002592 Family description; Region: UvrD_C_2; pfam13538 1087454002593 Predicted membrane protein [Function unknown]; Region: COG2259 1087454002594 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1087454002595 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1087454002596 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1087454002597 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1087454002598 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1087454002599 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1087454002600 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1087454002601 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1087454002602 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1087454002603 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1087454002604 23S rRNA binding site [nucleotide binding]; other site 1087454002605 L21 binding site [polypeptide binding]; other site 1087454002606 L13 binding site [polypeptide binding]; other site 1087454002607 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1087454002608 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1087454002609 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1087454002610 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1087454002611 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1087454002612 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1087454002613 dimer interface [polypeptide binding]; other site 1087454002614 motif 1; other site 1087454002615 active site 1087454002616 motif 2; other site 1087454002617 motif 3; other site 1087454002618 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1087454002619 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1087454002620 putative tRNA-binding site [nucleotide binding]; other site 1087454002621 B3/4 domain; Region: B3_4; pfam03483 1087454002622 tRNA synthetase B5 domain; Region: B5; smart00874 1087454002623 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1087454002624 dimer interface [polypeptide binding]; other site 1087454002625 motif 1; other site 1087454002626 motif 3; other site 1087454002627 motif 2; other site 1087454002628 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1087454002629 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1087454002630 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1087454002631 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1087454002632 feedback inhibition sensing region; other site 1087454002633 homohexameric interface [polypeptide binding]; other site 1087454002634 nucleotide binding site [chemical binding]; other site 1087454002635 N-acetyl-L-glutamate binding site [chemical binding]; other site 1087454002636 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1087454002637 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1087454002638 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1087454002639 arginine repressor; Provisional; Region: PRK03341 1087454002640 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1087454002641 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1087454002642 argininosuccinate synthase; Provisional; Region: PRK13820 1087454002643 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1087454002644 ANP binding site [chemical binding]; other site 1087454002645 Substrate Binding Site II [chemical binding]; other site 1087454002646 Substrate Binding Site I [chemical binding]; other site 1087454002647 argininosuccinate lyase; Provisional; Region: PRK00855 1087454002648 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1087454002649 active sites [active] 1087454002650 tetramer interface [polypeptide binding]; other site 1087454002651 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1087454002652 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1087454002653 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1087454002654 active site 1087454002655 HIGH motif; other site 1087454002656 dimer interface [polypeptide binding]; other site 1087454002657 KMSKS motif; other site 1087454002658 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1087454002659 RNA binding surface [nucleotide binding]; other site 1087454002660 transcription termination factor Rho; Provisional; Region: PRK12678 1087454002661 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1087454002662 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1087454002663 active site 1087454002664 motif I; other site 1087454002665 motif II; other site 1087454002666 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1087454002667 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1087454002668 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1087454002669 RNA binding surface [nucleotide binding]; other site 1087454002670 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1087454002671 S-adenosylmethionine binding site [chemical binding]; other site 1087454002672 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1087454002673 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1087454002674 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1087454002675 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1087454002676 Walker A/P-loop; other site 1087454002677 ATP binding site [chemical binding]; other site 1087454002678 Q-loop/lid; other site 1087454002679 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1087454002680 ABC transporter signature motif; other site 1087454002681 Walker B; other site 1087454002682 D-loop; other site 1087454002683 H-loop/switch region; other site 1087454002684 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1087454002685 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 1087454002686 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1087454002687 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1087454002688 dimer interface [polypeptide binding]; other site 1087454002689 ADP-ribose binding site [chemical binding]; other site 1087454002690 active site 1087454002691 nudix motif; other site 1087454002692 metal binding site [ion binding]; metal-binding site 1087454002693 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1087454002694 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1087454002695 active site 1087454002696 DNA binding site [nucleotide binding] 1087454002697 Int/Topo IB signature motif; other site 1087454002698 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1087454002699 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1087454002700 P-loop; other site 1087454002701 Magnesium ion binding site [ion binding]; other site 1087454002702 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1087454002703 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1087454002704 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1087454002705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087454002706 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05630 1087454002707 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1087454002708 inhibitor-cofactor binding pocket; inhibition site 1087454002709 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1087454002710 catalytic residue [active] 1087454002711 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1087454002712 AAA domain; Region: AAA_26; pfam13500 1087454002713 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1087454002714 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1087454002715 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1087454002716 RNA binding surface [nucleotide binding]; other site 1087454002717 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1087454002718 active site 1087454002719 cytidylate kinase; Provisional; Region: cmk; PRK00023 1087454002720 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1087454002721 CMP-binding site; other site 1087454002722 The sites determining sugar specificity; other site 1087454002723 GTP-binding protein Der; Reviewed; Region: PRK03003 1087454002724 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1087454002725 G1 box; other site 1087454002726 GTP/Mg2+ binding site [chemical binding]; other site 1087454002727 Switch I region; other site 1087454002728 G2 box; other site 1087454002729 Switch II region; other site 1087454002730 G3 box; other site 1087454002731 G4 box; other site 1087454002732 G5 box; other site 1087454002733 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1087454002734 G1 box; other site 1087454002735 GTP/Mg2+ binding site [chemical binding]; other site 1087454002736 Switch I region; other site 1087454002737 G2 box; other site 1087454002738 G3 box; other site 1087454002739 Switch II region; other site 1087454002740 G4 box; other site 1087454002741 G5 box; other site 1087454002742 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1087454002743 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 1087454002744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1087454002745 S-adenosylmethionine binding site [chemical binding]; other site 1087454002746 Putative esterase; Region: Esterase; pfam00756 1087454002747 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1087454002748 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1087454002749 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1087454002750 intersubunit interface [polypeptide binding]; other site 1087454002751 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1087454002752 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1087454002753 dimer interface [polypeptide binding]; other site 1087454002754 ABC-ATPase subunit interface; other site 1087454002755 putative PBP binding regions; other site 1087454002756 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1087454002757 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1087454002758 ABC-ATPase subunit interface; other site 1087454002759 dimer interface [polypeptide binding]; other site 1087454002760 putative PBP binding regions; other site 1087454002761 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1087454002762 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1087454002763 Walker A/P-loop; other site 1087454002764 ATP binding site [chemical binding]; other site 1087454002765 Q-loop/lid; other site 1087454002766 ABC transporter signature motif; other site 1087454002767 Walker B; other site 1087454002768 D-loop; other site 1087454002769 H-loop/switch region; other site 1087454002770 IucA / IucC family; Region: IucA_IucC; pfam04183 1087454002771 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1087454002772 IucA / IucC family; Region: IucA_IucC; pfam04183 1087454002773 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1087454002774 H+ Antiporter protein; Region: 2A0121; TIGR00900 1087454002775 hypothetical protein; Provisional; Region: PRK01842 1087454002776 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1087454002777 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1087454002778 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 1087454002779 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1087454002780 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1087454002781 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1087454002782 nucleotide binding region [chemical binding]; other site 1087454002783 ATP-binding site [chemical binding]; other site 1087454002784 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1087454002785 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1087454002786 phosphopeptide binding site; other site 1087454002787 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1087454002788 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1087454002789 DNA binding residues [nucleotide binding] 1087454002790 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1087454002791 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1087454002792 DNA binding residues [nucleotide binding] 1087454002793 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1087454002794 putative dimer interface [polypeptide binding]; other site 1087454002795 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1087454002796 metal ion-dependent adhesion site (MIDAS); other site 1087454002797 Domain of unknown function DUF21; Region: DUF21; pfam01595 1087454002798 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1087454002799 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1087454002800 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1087454002801 Domain of unknown function DUF21; Region: DUF21; pfam01595 1087454002802 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1087454002803 Transporter associated domain; Region: CorC_HlyC; smart01091 1087454002804 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1087454002805 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1087454002806 ATP binding site [chemical binding]; other site 1087454002807 putative Mg++ binding site [ion binding]; other site 1087454002808 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1087454002809 nucleotide binding region [chemical binding]; other site 1087454002810 ATP-binding site [chemical binding]; other site 1087454002811 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1087454002812 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1087454002813 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1087454002814 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1087454002815 CoenzymeA binding site [chemical binding]; other site 1087454002816 subunit interaction site [polypeptide binding]; other site 1087454002817 PHB binding site; other site 1087454002818 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1087454002819 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1087454002820 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1087454002821 oligomer interface [polypeptide binding]; other site 1087454002822 metal binding site [ion binding]; metal-binding site 1087454002823 metal binding site [ion binding]; metal-binding site 1087454002824 putative Cl binding site [ion binding]; other site 1087454002825 hydrophobic gate; other site 1087454002826 periplasmic entrance; other site 1087454002827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1087454002828 S-adenosylmethionine binding site [chemical binding]; other site 1087454002829 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1087454002830 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1087454002831 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1087454002832 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1087454002833 metabolite-proton symporter; Region: 2A0106; TIGR00883 1087454002834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087454002835 putative substrate translocation pore; other site 1087454002836 YceI-like domain; Region: YceI; pfam04264 1087454002837 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1087454002838 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1087454002839 Ligand binding site; other site 1087454002840 Putative Catalytic site; other site 1087454002841 DXD motif; other site 1087454002842 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1087454002843 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1087454002844 putative active site [active] 1087454002845 catalytic triad [active] 1087454002846 putative dimer interface [polypeptide binding]; other site 1087454002847 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1087454002848 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1087454002849 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1087454002850 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1087454002851 precorrin-3B synthase; Region: CobG; TIGR02435 1087454002852 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1087454002853 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1087454002854 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1087454002855 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1087454002856 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1087454002857 active site 1087454002858 SAM binding site [chemical binding]; other site 1087454002859 homodimer interface [polypeptide binding]; other site 1087454002860 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1087454002861 active site 1087454002862 SAM binding site [chemical binding]; other site 1087454002863 homodimer interface [polypeptide binding]; other site 1087454002864 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 1087454002865 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1087454002866 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 1087454002867 active site 1087454002868 SAM binding site [chemical binding]; other site 1087454002869 homodimer interface [polypeptide binding]; other site 1087454002870 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1087454002871 active site 1087454002872 putative homodimer interface [polypeptide binding]; other site 1087454002873 SAM binding site [chemical binding]; other site 1087454002874 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1087454002875 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 1087454002876 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1087454002877 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1087454002878 NAD(P) binding site [chemical binding]; other site 1087454002879 active site 1087454002880 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1087454002881 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1087454002882 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1087454002883 active site 1087454002884 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1087454002885 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1087454002886 ATP binding site [chemical binding]; other site 1087454002887 putative Mg++ binding site [ion binding]; other site 1087454002888 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1087454002889 nucleotide binding region [chemical binding]; other site 1087454002890 ATP-binding site [chemical binding]; other site 1087454002891 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1087454002892 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1087454002893 twin arginine translocase protein A; Provisional; Region: tatA; PRK00191 1087454002894 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1087454002895 Predicted transcriptional regulator [Transcription]; Region: COG2378 1087454002896 WYL domain; Region: WYL; pfam13280 1087454002897 Predicted transcriptional regulator [Transcription]; Region: COG2378 1087454002898 WYL domain; Region: WYL; pfam13280 1087454002899 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 1087454002900 Pup-like protein; Region: Pup; pfam05639 1087454002901 Pup-ligase protein; Region: Pup_ligase; cl15463 1087454002902 proteasome ATPase; Region: pup_AAA; TIGR03689 1087454002903 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1087454002904 Walker A motif; other site 1087454002905 ATP binding site [chemical binding]; other site 1087454002906 Walker B motif; other site 1087454002907 arginine finger; other site 1087454002908 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1087454002909 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1087454002910 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1087454002911 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1087454002912 active site 1087454002913 metal binding site [ion binding]; metal-binding site 1087454002914 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1087454002915 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1087454002916 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1087454002917 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1087454002918 Potassium binding sites [ion binding]; other site 1087454002919 Cesium cation binding sites [ion binding]; other site 1087454002920 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1087454002921 Aspartase; Region: Aspartase; cd01357 1087454002922 active sites [active] 1087454002923 tetramer interface [polypeptide binding]; other site 1087454002924 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1087454002925 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1087454002926 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1087454002927 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1087454002928 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1087454002929 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1087454002930 homodimer interface [polypeptide binding]; other site 1087454002931 putative metal binding site [ion binding]; other site 1087454002932 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1087454002933 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1087454002934 motif II; other site 1087454002935 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 1087454002936 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1087454002937 active site 1087454002938 HIGH motif; other site 1087454002939 nucleotide binding site [chemical binding]; other site 1087454002940 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1087454002941 active site 1087454002942 KMSKS motif; other site 1087454002943 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1087454002944 tRNA binding surface [nucleotide binding]; other site 1087454002945 anticodon binding site; other site 1087454002946 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 1087454002947 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1087454002948 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1087454002949 active site 1087454002950 catalytic tetrad [active] 1087454002951 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1087454002952 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1087454002953 quinone interaction residues [chemical binding]; other site 1087454002954 active site 1087454002955 catalytic residues [active] 1087454002956 FMN binding site [chemical binding]; other site 1087454002957 substrate binding site [chemical binding]; other site 1087454002958 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1087454002959 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1087454002960 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1087454002961 dimerization domain swap beta strand [polypeptide binding]; other site 1087454002962 regulatory protein interface [polypeptide binding]; other site 1087454002963 active site 1087454002964 regulatory phosphorylation site [posttranslational modification]; other site 1087454002965 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 1087454002966 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1087454002967 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1087454002968 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1087454002969 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1087454002970 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1087454002971 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1087454002972 NAD(P) binding site [chemical binding]; other site 1087454002973 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1087454002974 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1087454002975 NAD(P) binding site [chemical binding]; other site 1087454002976 active site 1087454002977 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1087454002978 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1087454002979 Walker A; other site 1087454002980 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1087454002981 G4 box; other site 1087454002982 G5 box; other site 1087454002983 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1087454002984 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1087454002985 active site 1087454002986 substrate binding site [chemical binding]; other site 1087454002987 coenzyme B12 binding site [chemical binding]; other site 1087454002988 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1087454002989 B12 binding site [chemical binding]; other site 1087454002990 cobalt ligand [ion binding]; other site 1087454002991 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1087454002992 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1087454002993 heterodimer interface [polypeptide binding]; other site 1087454002994 substrate interaction site [chemical binding]; other site 1087454002995 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1087454002996 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1087454002997 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1087454002998 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1087454002999 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1087454003000 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1087454003001 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1087454003002 ferrochelatase; Reviewed; Region: hemH; PRK00035 1087454003003 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1087454003004 C-terminal domain interface [polypeptide binding]; other site 1087454003005 active site 1087454003006 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1087454003007 active site 1087454003008 N-terminal domain interface [polypeptide binding]; other site 1087454003009 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1087454003010 NlpC/P60 family; Region: NLPC_P60; pfam00877 1087454003011 pyruvate carboxylase subunit A; Validated; Region: PRK07178 1087454003012 aconitate hydratase; Validated; Region: PRK09277 1087454003013 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1087454003014 substrate binding site [chemical binding]; other site 1087454003015 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1087454003016 ligand binding site [chemical binding]; other site 1087454003017 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1087454003018 substrate binding site [chemical binding]; other site 1087454003019 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1087454003020 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1087454003021 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1087454003022 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cd03128 1087454003023 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1087454003024 catalytic triad [active] 1087454003025 conserved cys residue [active] 1087454003026 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 1087454003027 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 1087454003028 AAA ATPase domain; Region: AAA_16; pfam13191 1087454003029 AAA domain; Region: AAA_22; pfam13401 1087454003030 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1087454003031 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1087454003032 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1087454003033 Walker A/P-loop; other site 1087454003034 ATP binding site [chemical binding]; other site 1087454003035 Q-loop/lid; other site 1087454003036 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1087454003037 ABC transporter signature motif; other site 1087454003038 Walker B; other site 1087454003039 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1087454003040 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1087454003041 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1087454003042 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1087454003043 trimerization site [polypeptide binding]; other site 1087454003044 active site 1087454003045 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1087454003046 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1087454003047 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1087454003048 catalytic residue [active] 1087454003049 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1087454003050 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1087454003051 Walker A/P-loop; other site 1087454003052 ATP binding site [chemical binding]; other site 1087454003053 Q-loop/lid; other site 1087454003054 ABC transporter signature motif; other site 1087454003055 Walker B; other site 1087454003056 D-loop; other site 1087454003057 H-loop/switch region; other site 1087454003058 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1087454003059 FeS assembly protein SufD; Region: sufD; TIGR01981 1087454003060 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1087454003061 FeS assembly protein SufB; Region: sufB; TIGR01980 1087454003062 Predicted transcriptional regulator [Transcription]; Region: COG2345 1087454003063 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1087454003064 putative DNA binding site [nucleotide binding]; other site 1087454003065 putative Zn2+ binding site [ion binding]; other site 1087454003066 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1087454003067 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1087454003068 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1087454003069 Walker A/P-loop; other site 1087454003070 ATP binding site [chemical binding]; other site 1087454003071 Q-loop/lid; other site 1087454003072 ABC transporter signature motif; other site 1087454003073 Walker B; other site 1087454003074 D-loop; other site 1087454003075 H-loop/switch region; other site 1087454003076 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1087454003077 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1087454003078 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1087454003079 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1087454003080 UbiA prenyltransferase family; Region: UbiA; pfam01040 1087454003081 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1087454003082 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1087454003083 TPP-binding site [chemical binding]; other site 1087454003084 dimer interface [polypeptide binding]; other site 1087454003085 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1087454003086 PYR/PP interface [polypeptide binding]; other site 1087454003087 dimer interface [polypeptide binding]; other site 1087454003088 TPP binding site [chemical binding]; other site 1087454003089 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1087454003090 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1087454003091 putative active site [active] 1087454003092 transaldolase; Provisional; Region: PRK03903 1087454003093 catalytic residue [active] 1087454003094 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1087454003095 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1087454003096 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1087454003097 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1087454003098 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 1087454003099 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1087454003100 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1087454003101 putative active site [active] 1087454003102 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 1087454003103 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1087454003104 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1087454003105 triosephosphate isomerase; Provisional; Region: PRK14567 1087454003106 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1087454003107 substrate binding site [chemical binding]; other site 1087454003108 dimer interface [polypeptide binding]; other site 1087454003109 catalytic triad [active] 1087454003110 Phosphoglycerate kinase; Region: PGK; pfam00162 1087454003111 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1087454003112 substrate binding site [chemical binding]; other site 1087454003113 hinge regions; other site 1087454003114 ADP binding site [chemical binding]; other site 1087454003115 catalytic site [active] 1087454003116 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1087454003117 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1087454003118 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1087454003119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1087454003120 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1087454003121 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1087454003122 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1087454003123 phosphate binding site [ion binding]; other site 1087454003124 putative substrate binding pocket [chemical binding]; other site 1087454003125 dimer interface [polypeptide binding]; other site 1087454003126 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1087454003127 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1087454003128 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1087454003129 GIY-YIG motif/motif A; other site 1087454003130 active site 1087454003131 catalytic site [active] 1087454003132 putative DNA binding site [nucleotide binding]; other site 1087454003133 metal binding site [ion binding]; metal-binding site 1087454003134 UvrB/uvrC motif; Region: UVR; pfam02151 1087454003135 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1087454003136 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1087454003137 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1087454003138 homopentamer interface [polypeptide binding]; other site 1087454003139 active site 1087454003140 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1087454003141 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1087454003142 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1087454003143 dimerization interface [polypeptide binding]; other site 1087454003144 active site 1087454003145 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1087454003146 Lumazine binding domain; Region: Lum_binding; pfam00677 1087454003147 Lumazine binding domain; Region: Lum_binding; pfam00677 1087454003148 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1087454003149 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1087454003150 catalytic motif [active] 1087454003151 Zn binding site [ion binding]; other site 1087454003152 RibD C-terminal domain; Region: RibD_C; pfam01872 1087454003153 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1087454003154 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1087454003155 substrate binding site [chemical binding]; other site 1087454003156 hexamer interface [polypeptide binding]; other site 1087454003157 metal binding site [ion binding]; metal-binding site 1087454003158 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1087454003159 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1087454003160 putative RNA binding site [nucleotide binding]; other site 1087454003161 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1087454003162 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1087454003163 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1087454003164 putative active site [active] 1087454003165 substrate binding site [chemical binding]; other site 1087454003166 putative cosubstrate binding site; other site 1087454003167 catalytic site [active] 1087454003168 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1087454003169 substrate binding site [chemical binding]; other site 1087454003170 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1087454003171 active site 1087454003172 catalytic residues [active] 1087454003173 metal binding site [ion binding]; metal-binding site 1087454003174 primosome assembly protein PriA; Provisional; Region: PRK14873 1087454003175 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1087454003176 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1087454003177 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1087454003178 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1087454003179 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1087454003180 Flavoprotein; Region: Flavoprotein; pfam02441 1087454003181 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1087454003182 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 1087454003183 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1087454003184 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1087454003185 catalytic site [active] 1087454003186 G-X2-G-X-G-K; other site 1087454003187 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1087454003188 active site 1087454003189 dimer interface [polypeptide binding]; other site 1087454003190 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1087454003191 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1087454003192 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1087454003193 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1087454003194 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1087454003195 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1087454003196 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1087454003197 IMP binding site; other site 1087454003198 dimer interface [polypeptide binding]; other site 1087454003199 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1087454003200 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1087454003201 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1087454003202 catalytic site [active] 1087454003203 subunit interface [polypeptide binding]; other site 1087454003204 dihydroorotase; Validated; Region: pyrC; PRK09357 1087454003205 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1087454003206 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1087454003207 active site 1087454003208 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1087454003209 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1087454003210 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1087454003211 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1087454003212 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1087454003213 active site 1087454003214 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 1087454003215 putative hydrophobic ligand binding site [chemical binding]; other site 1087454003216 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1087454003217 TIGR01777 family protein; Region: yfcH 1087454003218 NAD(P) binding site [chemical binding]; other site 1087454003219 active site 1087454003220 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1087454003221 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1087454003222 putative RNA binding site [nucleotide binding]; other site 1087454003223 elongation factor P; Validated; Region: PRK00529 1087454003224 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1087454003225 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1087454003226 RNA binding site [nucleotide binding]; other site 1087454003227 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1087454003228 RNA binding site [nucleotide binding]; other site 1087454003229 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1087454003230 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1087454003231 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1087454003232 active site 1087454003233 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1087454003234 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1087454003235 trimer interface [polypeptide binding]; other site 1087454003236 active site 1087454003237 dimer interface [polypeptide binding]; other site 1087454003238 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1087454003239 active site 1087454003240 dimer interface [polypeptide binding]; other site 1087454003241 metal binding site [ion binding]; metal-binding site 1087454003242 shikimate kinase; Reviewed; Region: aroK; PRK00131 1087454003243 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1087454003244 ADP binding site [chemical binding]; other site 1087454003245 magnesium binding site [ion binding]; other site 1087454003246 putative shikimate binding site; other site 1087454003247 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1087454003248 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1087454003249 Tetramer interface [polypeptide binding]; other site 1087454003250 active site 1087454003251 FMN-binding site [chemical binding]; other site 1087454003252 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1087454003253 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1087454003254 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1087454003255 shikimate binding site; other site 1087454003256 NAD(P) binding site [chemical binding]; other site 1087454003257 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 1087454003258 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1087454003259 dimerization interface [polypeptide binding]; other site 1087454003260 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1087454003261 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1087454003262 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1087454003263 motif 1; other site 1087454003264 active site 1087454003265 motif 2; other site 1087454003266 motif 3; other site 1087454003267 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1087454003268 DHHA1 domain; Region: DHHA1; pfam02272 1087454003269 recombination factor protein RarA; Reviewed; Region: PRK13342 1087454003270 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1087454003271 Walker A motif; other site 1087454003272 ATP binding site [chemical binding]; other site 1087454003273 Walker B motif; other site 1087454003274 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1087454003275 Phosphotransferase enzyme family; Region: APH; pfam01636 1087454003276 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1087454003277 substrate binding site [chemical binding]; other site 1087454003278 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1087454003279 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1087454003280 dimer interface [polypeptide binding]; other site 1087454003281 anticodon binding site; other site 1087454003282 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1087454003283 homodimer interface [polypeptide binding]; other site 1087454003284 motif 1; other site 1087454003285 active site 1087454003286 motif 2; other site 1087454003287 GAD domain; Region: GAD; pfam02938 1087454003288 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1087454003289 active site 1087454003290 motif 3; other site 1087454003291 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1087454003292 Predicted membrane protein [Function unknown]; Region: COG1511 1087454003293 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1087454003294 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1087454003295 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1087454003296 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1087454003297 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 1087454003298 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1087454003299 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1087454003300 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 1087454003301 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1087454003302 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1087454003303 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1087454003304 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1087454003305 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1087454003306 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1087454003307 putative active site [active] 1087454003308 putative catalytic site [active] 1087454003309 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1087454003310 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1087454003311 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1087454003312 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1087454003313 dimer interface [polypeptide binding]; other site 1087454003314 motif 1; other site 1087454003315 active site 1087454003316 motif 2; other site 1087454003317 motif 3; other site 1087454003318 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1087454003319 anticodon binding site; other site 1087454003320 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1087454003321 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1087454003322 dimer interface [polypeptide binding]; other site 1087454003323 catalytic triad [active] 1087454003324 peroxidatic and resolving cysteines [active] 1087454003325 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1087454003326 active site 1087454003327 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1087454003328 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1087454003329 Zn2+ binding site [ion binding]; other site 1087454003330 Mg2+ binding site [ion binding]; other site 1087454003331 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1087454003332 synthetase active site [active] 1087454003333 NTP binding site [chemical binding]; other site 1087454003334 metal binding site [ion binding]; metal-binding site 1087454003335 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1087454003336 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1087454003337 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1087454003338 active site 1087454003339 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1087454003340 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1087454003341 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1087454003342 Protein export membrane protein; Region: SecD_SecF; pfam02355 1087454003343 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 1087454003344 Protein export membrane protein; Region: SecD_SecF; cl14618 1087454003345 Preprotein translocase subunit; Region: YajC; pfam02699 1087454003346 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1087454003347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1087454003348 Walker A motif; other site 1087454003349 ATP binding site [chemical binding]; other site 1087454003350 Walker B motif; other site 1087454003351 arginine finger; other site 1087454003352 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1087454003353 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1087454003354 RuvA N terminal domain; Region: RuvA_N; pfam01330 1087454003355 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1087454003356 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1087454003357 active site 1087454003358 putative DNA-binding cleft [nucleotide binding]; other site 1087454003359 dimer interface [polypeptide binding]; other site 1087454003360 hypothetical protein; Validated; Region: PRK00110 1087454003361 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1087454003362 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1087454003363 active site 1087454003364 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1087454003365 catalytic triad [active] 1087454003366 dimer interface [polypeptide binding]; other site 1087454003367 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1087454003368 6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322 1087454003369 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1087454003370 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1087454003371 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1087454003372 catalytic residue [active] 1087454003373 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1087454003374 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1087454003375 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1087454003376 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1087454003377 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1087454003378 putative acyl-acceptor binding pocket; other site 1087454003379 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1087454003380 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1087454003381 nucleotide binding site/active site [active] 1087454003382 HIT family signature motif; other site 1087454003383 catalytic residue [active] 1087454003384 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1087454003385 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1087454003386 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1087454003387 active site 1087454003388 dimer interface [polypeptide binding]; other site 1087454003389 motif 1; other site 1087454003390 motif 2; other site 1087454003391 motif 3; other site 1087454003392 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1087454003393 anticodon binding site; other site 1087454003394 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1087454003395 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1087454003396 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1087454003397 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 1087454003398 hypothetical protein; Provisional; Region: PRK14059 1087454003399 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1087454003400 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1087454003401 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1087454003402 SelR domain; Region: SelR; pfam01641 1087454003403 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1087454003404 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1087454003405 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1087454003406 catalytic site [active] 1087454003407 putative active site [active] 1087454003408 putative substrate binding site [chemical binding]; other site 1087454003409 HRDC domain; Region: HRDC; pfam00570 1087454003410 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1087454003411 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1087454003412 TPP-binding site; other site 1087454003413 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1087454003414 PYR/PP interface [polypeptide binding]; other site 1087454003415 dimer interface [polypeptide binding]; other site 1087454003416 TPP binding site [chemical binding]; other site 1087454003417 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1087454003418 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 1087454003419 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1087454003420 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1087454003421 S-adenosylmethionine binding site [chemical binding]; other site 1087454003422 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1087454003423 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1087454003424 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1087454003425 trimer interface [polypeptide binding]; other site 1087454003426 active site 1087454003427 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1087454003428 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1087454003429 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1087454003430 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1087454003431 nucleotide binding site [chemical binding]; other site 1087454003432 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1087454003433 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1087454003434 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1087454003435 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1087454003436 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1087454003437 DNA binding residues [nucleotide binding] 1087454003438 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1087454003439 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1087454003440 ATP binding site [chemical binding]; other site 1087454003441 putative Mg++ binding site [ion binding]; other site 1087454003442 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1087454003443 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1087454003444 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1087454003445 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1087454003446 S-adenosylmethionine binding site [chemical binding]; other site 1087454003447 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1087454003448 putative active site [active] 1087454003449 dimerization interface [polypeptide binding]; other site 1087454003450 putative tRNAtyr binding site [nucleotide binding]; other site 1087454003451 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1087454003452 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1087454003453 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1087454003454 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1087454003455 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1087454003456 DNA binding residues [nucleotide binding] 1087454003457 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1087454003458 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1087454003459 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1087454003460 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1087454003461 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1087454003462 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1087454003463 NAD binding site [chemical binding]; other site 1087454003464 homodimer interface [polypeptide binding]; other site 1087454003465 active site 1087454003466 substrate binding site [chemical binding]; other site 1087454003467 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1087454003468 PAC2 family; Region: PAC2; pfam09754 1087454003469 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 1087454003470 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1087454003471 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1087454003472 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1087454003473 dimer interface [polypeptide binding]; other site 1087454003474 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1087454003475 catalytic triad [active] 1087454003476 peroxidatic and resolving cysteines [active] 1087454003477 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1087454003478 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1087454003479 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1087454003480 dimerization interface [polypeptide binding]; other site 1087454003481 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 1087454003482 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1087454003483 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1087454003484 ATP binding site [chemical binding]; other site 1087454003485 putative Mg++ binding site [ion binding]; other site 1087454003486 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1087454003487 nucleotide binding region [chemical binding]; other site 1087454003488 ATP-binding site [chemical binding]; other site 1087454003489 Helicase associated domain (HA2); Region: HA2; pfam04408 1087454003490 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1087454003491 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1087454003492 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1087454003493 ATP cone domain; Region: ATP-cone; pfam03477 1087454003494 LexA repressor; Validated; Region: PRK00215 1087454003495 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1087454003496 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1087454003497 Catalytic site [active] 1087454003498 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1087454003499 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1087454003500 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1087454003501 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1087454003502 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1087454003503 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1087454003504 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1087454003505 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1087454003506 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1087454003507 DNA-binding site [nucleotide binding]; DNA binding site 1087454003508 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1087454003509 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1087454003510 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1087454003511 putative substrate binding site [chemical binding]; other site 1087454003512 putative ATP binding site [chemical binding]; other site 1087454003513 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1087454003514 dimerization domain swap beta strand [polypeptide binding]; other site 1087454003515 regulatory protein interface [polypeptide binding]; other site 1087454003516 active site 1087454003517 regulatory phosphorylation site [posttranslational modification]; other site 1087454003518 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1087454003519 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1087454003520 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1087454003521 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 1087454003522 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1087454003523 GTPases [General function prediction only]; Region: HflX; COG2262 1087454003524 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1087454003525 HflX GTPase family; Region: HflX; cd01878 1087454003526 G1 box; other site 1087454003527 GTP/Mg2+ binding site [chemical binding]; other site 1087454003528 Switch I region; other site 1087454003529 G2 box; other site 1087454003530 G3 box; other site 1087454003531 Switch II region; other site 1087454003532 G4 box; other site 1087454003533 G5 box; other site 1087454003534 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1087454003535 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1087454003536 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1087454003537 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1087454003538 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1087454003539 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1087454003540 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1087454003541 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1087454003542 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 1087454003543 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1087454003544 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1087454003545 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1087454003546 FeS/SAM binding site; other site 1087454003547 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1087454003548 recombinase A; Provisional; Region: recA; PRK09354 1087454003549 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1087454003550 hexamer interface [polypeptide binding]; other site 1087454003551 Walker A motif; other site 1087454003552 ATP binding site [chemical binding]; other site 1087454003553 Walker B motif; other site 1087454003554 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1087454003555 BioY family; Region: BioY; pfam02632 1087454003556 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1087454003557 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1087454003558 Walker A/P-loop; other site 1087454003559 ATP binding site [chemical binding]; other site 1087454003560 Q-loop/lid; other site 1087454003561 ABC transporter signature motif; other site 1087454003562 Walker B; other site 1087454003563 D-loop; other site 1087454003564 H-loop/switch region; other site 1087454003565 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1087454003566 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1087454003567 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1087454003568 sequence-specific DNA binding site [nucleotide binding]; other site 1087454003569 salt bridge; other site 1087454003570 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1087454003571 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1087454003572 YCII-related domain; Region: YCII; cl00999 1087454003573 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1087454003574 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1087454003575 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1087454003576 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1087454003577 TIGR03085 family protein; Region: TIGR03085 1087454003578 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1087454003579 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1087454003580 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1087454003581 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1087454003582 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1087454003583 dimer interface [polypeptide binding]; other site 1087454003584 active site 1087454003585 catalytic residue [active] 1087454003586 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1087454003587 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1087454003588 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1087454003589 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1087454003590 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1087454003591 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1087454003592 oligomer interface [polypeptide binding]; other site 1087454003593 RNA binding site [nucleotide binding]; other site 1087454003594 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1087454003595 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1087454003596 RNase E interface [polypeptide binding]; other site 1087454003597 trimer interface [polypeptide binding]; other site 1087454003598 active site 1087454003599 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1087454003600 putative nucleic acid binding region [nucleotide binding]; other site 1087454003601 G-X-X-G motif; other site 1087454003602 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1087454003603 RNA binding site [nucleotide binding]; other site 1087454003604 domain interface; other site 1087454003605 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1087454003606 16S/18S rRNA binding site [nucleotide binding]; other site 1087454003607 S13e-L30e interaction site [polypeptide binding]; other site 1087454003608 25S rRNA binding site [nucleotide binding]; other site 1087454003609 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 1087454003610 active site 1087454003611 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1087454003612 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1087454003613 active site 1087454003614 Riboflavin kinase; Region: Flavokinase; smart00904 1087454003615 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1087454003616 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1087454003617 RNA binding site [nucleotide binding]; other site 1087454003618 active site 1087454003619 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1087454003620 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1087454003621 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1087454003622 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1087454003623 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1087454003624 active site 1087454003625 metal binding site [ion binding]; metal-binding site 1087454003626 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1087454003627 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1087454003628 DHH family; Region: DHH; pfam01368 1087454003629 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1087454003630 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1087454003631 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1087454003632 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1087454003633 G1 box; other site 1087454003634 putative GEF interaction site [polypeptide binding]; other site 1087454003635 GTP/Mg2+ binding site [chemical binding]; other site 1087454003636 Switch I region; other site 1087454003637 G2 box; other site 1087454003638 G3 box; other site 1087454003639 Switch II region; other site 1087454003640 G4 box; other site 1087454003641 G5 box; other site 1087454003642 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1087454003643 Translation-initiation factor 2; Region: IF-2; pfam11987 1087454003644 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1087454003645 Protein of unknown function (DUF448); Region: DUF448; pfam04296 1087454003646 putative RNA binding cleft [nucleotide binding]; other site 1087454003647 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1087454003648 NusA N-terminal domain; Region: NusA_N; pfam08529 1087454003649 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1087454003650 RNA binding site [nucleotide binding]; other site 1087454003651 homodimer interface [polypeptide binding]; other site 1087454003652 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1087454003653 G-X-X-G motif; other site 1087454003654 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1087454003655 G-X-X-G motif; other site 1087454003656 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1087454003657 Sm and related proteins; Region: Sm_like; cl00259 1087454003658 heptamer interface [polypeptide binding]; other site 1087454003659 Sm1 motif; other site 1087454003660 hexamer interface [polypeptide binding]; other site 1087454003661 RNA binding site [nucleotide binding]; other site 1087454003662 Sm2 motif; other site 1087454003663 hypothetical protein; Validated; Region: PRK02101 1087454003664 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1087454003665 active site 1087454003666 SAM binding site [chemical binding]; other site 1087454003667 homodimer interface [polypeptide binding]; other site 1087454003668 hypothetical protein; Validated; Region: PRK00029 1087454003669 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1087454003670 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1087454003671 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1087454003672 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1087454003673 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1087454003674 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1087454003675 DNA binding site [nucleotide binding] 1087454003676 active site 1087454003677 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 1087454003678 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1087454003679 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1087454003680 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1087454003681 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1087454003682 homodimer interface [polypeptide binding]; other site 1087454003683 Walker A motif; other site 1087454003684 ATP binding site [chemical binding]; other site 1087454003685 hydroxycobalamin binding site [chemical binding]; other site 1087454003686 Walker B motif; other site 1087454003687 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1087454003688 metal ion-dependent adhesion site (MIDAS); other site 1087454003689 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 1087454003690 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1087454003691 Walker A motif; other site 1087454003692 ATP binding site [chemical binding]; other site 1087454003693 Walker B motif; other site 1087454003694 arginine finger; other site 1087454003695 malate:quinone oxidoreductase; Validated; Region: PRK05257 1087454003696 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1087454003697 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1087454003698 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1087454003699 mycothione reductase; Reviewed; Region: PRK07846 1087454003700 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1087454003701 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1087454003702 cobyric acid synthase; Provisional; Region: PRK00784 1087454003703 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1087454003704 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1087454003705 catalytic triad [active] 1087454003706 methionine aminopeptidase; Provisional; Region: PRK12318 1087454003707 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1087454003708 active site 1087454003709 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1087454003710 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1087454003711 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1087454003712 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1087454003713 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1087454003714 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1087454003715 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1087454003716 active site 1087454003717 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1087454003718 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1087454003719 putative substrate binding region [chemical binding]; other site 1087454003720 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1087454003721 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1087454003722 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1087454003723 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1087454003724 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 1087454003725 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1087454003726 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1087454003727 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1087454003728 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1087454003729 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1087454003730 hinge region; other site 1087454003731 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1087454003732 putative nucleotide binding site [chemical binding]; other site 1087454003733 uridine monophosphate binding site [chemical binding]; other site 1087454003734 homohexameric interface [polypeptide binding]; other site 1087454003735 elongation factor Ts; Provisional; Region: tsf; PRK09377 1087454003736 UBA/TS-N domain; Region: UBA; pfam00627 1087454003737 Elongation factor TS; Region: EF_TS; pfam00889 1087454003738 Elongation factor TS; Region: EF_TS; pfam00889 1087454003739 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1087454003740 rRNA interaction site [nucleotide binding]; other site 1087454003741 S8 interaction site; other site 1087454003742 putative laminin-1 binding site; other site 1087454003743 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1087454003744 Peptidase family M23; Region: Peptidase_M23; pfam01551 1087454003745 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1087454003746 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1087454003747 active site 1087454003748 DNA binding site [nucleotide binding] 1087454003749 Int/Topo IB signature motif; other site 1087454003750 DNA protecting protein DprA; Region: dprA; TIGR00732 1087454003751 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1087454003752 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1087454003753 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1087454003754 Walker A motif; other site 1087454003755 ATP binding site [chemical binding]; other site 1087454003756 Walker B motif; other site 1087454003757 arginine finger; other site 1087454003758 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1087454003759 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 1087454003760 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 1087454003761 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1087454003762 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1087454003763 RNA/DNA hybrid binding site [nucleotide binding]; other site 1087454003764 active site 1087454003765 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1087454003766 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1087454003767 Catalytic site [active] 1087454003768 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1087454003769 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1087454003770 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1087454003771 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1087454003772 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1087454003773 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1087454003774 RNA binding site [nucleotide binding]; other site 1087454003775 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1087454003776 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1087454003777 active site 1087454003778 P-loop; other site 1087454003779 phosphorylation site [posttranslational modification] 1087454003780 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1087454003781 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1087454003782 active site 1087454003783 phosphorylation site [posttranslational modification] 1087454003784 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1087454003785 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1087454003786 RimM N-terminal domain; Region: RimM; pfam01782 1087454003787 PRC-barrel domain; Region: PRC; pfam05239 1087454003788 Cupin domain; Region: Cupin_2; cl17218 1087454003789 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1087454003790 signal recognition particle protein; Provisional; Region: PRK10867 1087454003791 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1087454003792 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1087454003793 P loop; other site 1087454003794 GTP binding site [chemical binding]; other site 1087454003795 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1087454003796 PII uridylyl-transferase; Provisional; Region: glnD; PRK00227 1087454003797 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1087454003798 metal binding triad; other site 1087454003799 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1087454003800 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1087454003801 Zn2+ binding site [ion binding]; other site 1087454003802 Mg2+ binding site [ion binding]; other site 1087454003803 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1087454003804 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1087454003805 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1087454003806 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1087454003807 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1087454003808 Acylphosphatase; Region: Acylphosphatase; cl00551 1087454003809 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1087454003810 amino acid carrier protein; Region: agcS; TIGR00835 1087454003811 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK14810 1087454003812 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1087454003813 DNA binding site [nucleotide binding] 1087454003814 putative catalytic residues [active] 1087454003815 turnover-facilitating residue; other site 1087454003816 intercalation triad [nucleotide binding]; other site 1087454003817 8OG recognition residue [nucleotide binding]; other site 1087454003818 putative reading head residues; other site 1087454003819 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1087454003820 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1087454003821 ribonuclease III; Reviewed; Region: rnc; PRK00102 1087454003822 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1087454003823 dimerization interface [polypeptide binding]; other site 1087454003824 active site 1087454003825 metal binding site [ion binding]; metal-binding site 1087454003826 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1087454003827 dsRNA binding site [nucleotide binding]; other site 1087454003828 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1087454003829 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1087454003830 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1087454003831 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1087454003832 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1087454003833 hexamer interface [polypeptide binding]; other site 1087454003834 ligand binding site [chemical binding]; other site 1087454003835 putative active site [active] 1087454003836 NAD(P) binding site [chemical binding]; other site 1087454003837 glutamate dehydrogenase; Provisional; Region: PRK09414 1087454003838 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1087454003839 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1087454003840 NAD(P) binding site [chemical binding]; other site 1087454003841 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1087454003842 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1087454003843 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1087454003844 nucleotide binding site/active site [active] 1087454003845 HIT family signature motif; other site 1087454003846 catalytic residue [active] 1087454003847 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1087454003848 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1087454003849 metal binding site [ion binding]; metal-binding site 1087454003850 putative dimer interface [polypeptide binding]; other site 1087454003851 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1087454003852 homodimer interface [polypeptide binding]; other site 1087454003853 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1087454003854 active site pocket [active] 1087454003855 Electron transfer DM13; Region: DM13; pfam10517 1087454003856 pyruvate kinase; Provisional; Region: PRK06247 1087454003857 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1087454003858 domain interfaces; other site 1087454003859 active site 1087454003860 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1087454003861 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1087454003862 active site 1087454003863 ribulose/triose binding site [chemical binding]; other site 1087454003864 phosphate binding site [ion binding]; other site 1087454003865 substrate (anthranilate) binding pocket [chemical binding]; other site 1087454003866 product (indole) binding pocket [chemical binding]; other site 1087454003867 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 1087454003868 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1087454003869 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1087454003870 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1087454003871 substrate binding site [chemical binding]; other site 1087454003872 glutamase interaction surface [polypeptide binding]; other site 1087454003873 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1087454003874 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1087454003875 active site 1087454003876 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1087454003877 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1087454003878 catalytic residues [active] 1087454003879 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1087454003880 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1087454003881 putative active site [active] 1087454003882 oxyanion strand; other site 1087454003883 catalytic triad [active] 1087454003884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087454003885 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1087454003886 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087454003887 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1087454003888 putative active site pocket [active] 1087454003889 4-fold oligomerization interface [polypeptide binding]; other site 1087454003890 metal binding residues [ion binding]; metal-binding site 1087454003891 3-fold/trimer interface [polypeptide binding]; other site 1087454003892 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1087454003893 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1087454003894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1087454003895 homodimer interface [polypeptide binding]; other site 1087454003896 catalytic residue [active] 1087454003897 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1087454003898 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1087454003899 NAD binding site [chemical binding]; other site 1087454003900 dimerization interface [polypeptide binding]; other site 1087454003901 product binding site; other site 1087454003902 substrate binding site [chemical binding]; other site 1087454003903 zinc binding site [ion binding]; other site 1087454003904 catalytic residues [active] 1087454003905 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1087454003906 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1087454003907 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1087454003908 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1087454003909 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1087454003910 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1087454003911 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1087454003912 active site 1087454003913 catalytic site [active] 1087454003914 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 1087454003915 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1087454003916 active site 1087454003917 catalytic site [active] 1087454003918 substrate binding site [chemical binding]; other site 1087454003919 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1087454003920 Dimer interface [polypeptide binding]; other site 1087454003921 BRCT sequence motif; other site 1087454003922 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1087454003923 synthetase active site [active] 1087454003924 NTP binding site [chemical binding]; other site 1087454003925 metal binding site [ion binding]; metal-binding site 1087454003926 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1087454003927 RNA binding surface [nucleotide binding]; other site 1087454003928 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1087454003929 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1087454003930 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1087454003931 threonine dehydratase; Validated; Region: PRK08639 1087454003932 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1087454003933 tetramer interface [polypeptide binding]; other site 1087454003934 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1087454003935 catalytic residue [active] 1087454003936 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 1087454003937 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1087454003938 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1087454003939 active site 1087454003940 PHP Thumb interface [polypeptide binding]; other site 1087454003941 metal binding site [ion binding]; metal-binding site 1087454003942 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1087454003943 generic binding surface I; other site 1087454003944 generic binding surface II; other site 1087454003945 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1087454003946 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1087454003947 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1087454003948 RNA binding surface [nucleotide binding]; other site 1087454003949 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1087454003950 active site 1087454003951 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1087454003952 lipoprotein signal peptidase; Provisional; Region: PRK14787 1087454003953 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1087454003954 active site 1087454003955 homodimer interface [polypeptide binding]; other site 1087454003956 homotetramer interface [polypeptide binding]; other site 1087454003957 DNA polymerase IV; Provisional; Region: PRK03348 1087454003958 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1087454003959 DNA binding site [nucleotide binding] 1087454003960 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1087454003961 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1087454003962 HIGH motif; other site 1087454003963 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1087454003964 active site 1087454003965 KMSKS motif; other site 1087454003966 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1087454003967 tRNA binding surface [nucleotide binding]; other site 1087454003968 anticodon binding site; other site 1087454003969 DivIVA protein; Region: DivIVA; pfam05103 1087454003970 DivIVA domain; Region: DivI1A_domain; TIGR03544 1087454003971 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1087454003972 YGGT family; Region: YGGT; pfam02325 1087454003973 Protein of unknown function (DUF552); Region: DUF552; cl00775 1087454003974 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1087454003975 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1087454003976 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 1087454003977 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1087454003978 nucleotide binding site [chemical binding]; other site 1087454003979 SulA interaction site; other site 1087454003980 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1087454003981 Cell division protein FtsQ; Region: FtsQ; pfam03799 1087454003982 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1087454003983 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1087454003984 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1087454003985 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1087454003986 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1087454003987 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1087454003988 homodimer interface [polypeptide binding]; other site 1087454003989 active site 1087454003990 cell division protein FtsW; Region: ftsW; TIGR02614 1087454003991 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141 1087454003992 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1087454003993 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1087454003994 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1087454003995 Mg++ binding site [ion binding]; other site 1087454003996 putative catalytic motif [active] 1087454003997 putative substrate binding site [chemical binding]; other site 1087454003998 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1087454003999 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1087454004000 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1087454004001 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1087454004002 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1087454004003 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1087454004004 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1087454004005 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1087454004006 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1087454004007 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1087454004008 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1087454004009 MraW methylase family; Region: Methyltransf_5; cl17771 1087454004010 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1087454004011 cell division protein MraZ; Reviewed; Region: PRK00326 1087454004012 MraZ protein; Region: MraZ; pfam02381 1087454004013 MraZ protein; Region: MraZ; pfam02381 1087454004014 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1087454004015 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1087454004016 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1087454004017 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1087454004018 FAD binding site [chemical binding]; other site 1087454004019 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1087454004020 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1087454004021 substrate binding pocket [chemical binding]; other site 1087454004022 chain length determination region; other site 1087454004023 substrate-Mg2+ binding site; other site 1087454004024 catalytic residues [active] 1087454004025 aspartate-rich region 1; other site 1087454004026 active site lid residues [active] 1087454004027 aspartate-rich region 2; other site 1087454004028 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1087454004029 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1087454004030 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1087454004031 active site 1087454004032 ATP binding site [chemical binding]; other site 1087454004033 substrate binding site [chemical binding]; other site 1087454004034 activation loop (A-loop); other site 1087454004035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1087454004036 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1087454004037 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1087454004038 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1087454004039 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1087454004040 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1087454004041 Predicted membrane protein [Function unknown]; Region: COG4763 1087454004042 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1087454004043 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1087454004044 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1087454004045 putative acyl-acceptor binding pocket; other site 1087454004046 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1087454004047 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1087454004048 nucleotide binding site [chemical binding]; other site 1087454004049 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1087454004050 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1087454004051 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1087454004052 NlpC/P60 family; Region: NLPC_P60; pfam00877 1087454004053 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1087454004054 NlpC/P60 family; Region: NLPC_P60; pfam00877 1087454004055 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1087454004056 heme bH binding site [chemical binding]; other site 1087454004057 intrachain domain interface; other site 1087454004058 heme bL binding site [chemical binding]; other site 1087454004059 interchain domain interface [polypeptide binding]; other site 1087454004060 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1087454004061 Qo binding site; other site 1087454004062 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1087454004063 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1087454004064 iron-sulfur cluster [ion binding]; other site 1087454004065 [2Fe-2S] cluster binding site [ion binding]; other site 1087454004066 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1087454004067 Cytochrome c; Region: Cytochrom_C; pfam00034 1087454004068 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1087454004069 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1087454004070 Subunit I/III interface [polypeptide binding]; other site 1087454004071 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1087454004072 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1087454004073 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1087454004074 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1087454004075 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1087454004076 active site 1087454004077 dimer interface [polypeptide binding]; other site 1087454004078 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1087454004079 Ligand Binding Site [chemical binding]; other site 1087454004080 Molecular Tunnel; other site 1087454004081 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1087454004082 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1087454004083 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1087454004084 homotrimer interface [polypeptide binding]; other site 1087454004085 Walker A motif; other site 1087454004086 GTP binding site [chemical binding]; other site 1087454004087 Walker B motif; other site 1087454004088 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1087454004089 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1087454004090 putative dimer interface [polypeptide binding]; other site 1087454004091 active site pocket [active] 1087454004092 putative cataytic base [active] 1087454004093 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1087454004094 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1087454004095 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1087454004096 homodimer interface [polypeptide binding]; other site 1087454004097 substrate-cofactor binding pocket; other site 1087454004098 catalytic residue [active] 1087454004099 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1087454004100 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1087454004101 interface (dimer of trimers) [polypeptide binding]; other site 1087454004102 Substrate-binding/catalytic site; other site 1087454004103 Zn-binding sites [ion binding]; other site 1087454004104 glycine dehydrogenase; Provisional; Region: PRK05367 1087454004105 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1087454004106 tetramer interface [polypeptide binding]; other site 1087454004107 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1087454004108 catalytic residue [active] 1087454004109 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1087454004110 tetramer interface [polypeptide binding]; other site 1087454004111 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1087454004112 catalytic residue [active] 1087454004113 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1087454004114 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1087454004115 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1087454004116 lipoyl attachment site [posttranslational modification]; other site 1087454004117 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1087454004118 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1087454004119 active site 1087454004120 lipoate-protein ligase B; Provisional; Region: PRK14345 1087454004121 lipoyl synthase; Provisional; Region: PRK05481 1087454004122 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1087454004123 FeS/SAM binding site; other site 1087454004124 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1087454004125 RDD family; Region: RDD; pfam06271 1087454004126 glutamine synthetase, type I; Region: GlnA; TIGR00653 1087454004127 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1087454004128 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1087454004129 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1087454004130 Htaa; Region: HtaA; pfam04213 1087454004131 Htaa; Region: HtaA; pfam04213 1087454004132 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1087454004133 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1087454004134 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1087454004135 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 1087454004136 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1087454004137 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1087454004138 active site 1087454004139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 1087454004140 Predicted permease [General function prediction only]; Region: COG2056 1087454004141 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1087454004142 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 1087454004143 nudix motif; other site 1087454004144 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1087454004145 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1087454004146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1087454004147 catalytic residue [active] 1087454004148 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 1087454004149 active site 1087454004150 catalytic site [active] 1087454004151 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1087454004152 heme binding pocket [chemical binding]; other site 1087454004153 heme ligand [chemical binding]; other site 1087454004154 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1087454004155 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1087454004156 metal binding triad; other site 1087454004157 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1087454004158 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1087454004159 metal binding triad; other site 1087454004160 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1087454004161 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1087454004162 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1087454004163 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1087454004164 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 1087454004165 putative active site; other site 1087454004166 putative metal binding residues [ion binding]; other site 1087454004167 signature motif; other site 1087454004168 putative triphosphate binding site [ion binding]; other site 1087454004169 CHAD domain; Region: CHAD; pfam05235 1087454004170 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1087454004171 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1087454004172 RNB domain; Region: RNB; pfam00773 1087454004173 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 1087454004174 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1087454004175 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1087454004176 RNA/DNA hybrid binding site [nucleotide binding]; other site 1087454004177 active site 1087454004178 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1087454004179 catalytic core [active] 1087454004180 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1087454004181 Putative zinc ribbon domain; Region: DUF164; pfam02591 1087454004182 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1087454004183 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1087454004184 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1087454004185 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1087454004186 hypothetical protein; Provisional; Region: PRK07908 1087454004187 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1087454004188 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1087454004189 homodimer interface [polypeptide binding]; other site 1087454004190 catalytic residue [active] 1087454004191 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1087454004192 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1087454004193 motif II; other site 1087454004194 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1087454004195 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1087454004196 active site 1087454004197 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1087454004198 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1087454004199 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1087454004200 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1087454004201 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1087454004202 dimer interface [polypeptide binding]; other site 1087454004203 TPP-binding site [chemical binding]; other site 1087454004204 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1087454004205 Serine hydrolase; Region: Ser_hydrolase; cl17834 1087454004206 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1087454004207 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1087454004208 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1087454004209 active site 1087454004210 motif I; other site 1087454004211 motif II; other site 1087454004212 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1087454004213 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1087454004214 Beta-lactamase; Region: Beta-lactamase; pfam00144 1087454004215 Predicted membrane protein [Function unknown]; Region: COG2860 1087454004216 UPF0126 domain; Region: UPF0126; pfam03458 1087454004217 UPF0126 domain; Region: UPF0126; pfam03458 1087454004218 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1087454004219 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1087454004220 glutaminase active site [active] 1087454004221 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1087454004222 dimer interface [polypeptide binding]; other site 1087454004223 active site 1087454004224 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1087454004225 dimer interface [polypeptide binding]; other site 1087454004226 active site 1087454004227 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 1087454004228 active site 1087454004229 barstar interaction site; other site 1087454004230 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1087454004231 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1087454004232 Zn2+ binding site [ion binding]; other site 1087454004233 Mg2+ binding site [ion binding]; other site 1087454004234 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1087454004235 Repair protein; Region: Repair_PSII; pfam04536 1087454004236 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1087454004237 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1087454004238 motif 1; other site 1087454004239 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1087454004240 active site 1087454004241 motif 2; other site 1087454004242 motif 3; other site 1087454004243 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1087454004244 anticodon binding site; other site 1087454004245 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1087454004246 putative DNA binding site [nucleotide binding]; other site 1087454004247 putative Zn2+ binding site [ion binding]; other site 1087454004248 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1087454004249 metal binding site 2 [ion binding]; metal-binding site 1087454004250 putative DNA binding helix; other site 1087454004251 metal binding site 1 [ion binding]; metal-binding site 1087454004252 dimer interface [polypeptide binding]; other site 1087454004253 structural Zn2+ binding site [ion binding]; other site 1087454004254 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 1087454004255 diiron binding motif [ion binding]; other site 1087454004256 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 1087454004257 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1087454004258 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1087454004259 putative FPP binding hydrophobic cleft; other site 1087454004260 dimer interface [polypeptide binding]; other site 1087454004261 putative IPP diphosphate binding site; other site 1087454004262 Recombination protein O N terminal; Region: RecO_N; pfam11967 1087454004263 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1087454004264 Recombination protein O C terminal; Region: RecO_C; pfam02565 1087454004265 GTPase Era; Reviewed; Region: era; PRK00089 1087454004266 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1087454004267 G1 box; other site 1087454004268 GTP/Mg2+ binding site [chemical binding]; other site 1087454004269 Switch I region; other site 1087454004270 G2 box; other site 1087454004271 Switch II region; other site 1087454004272 G3 box; other site 1087454004273 G4 box; other site 1087454004274 G5 box; other site 1087454004275 KH domain; Region: KH_2; pfam07650 1087454004276 pyridoxamine kinase; Validated; Region: PRK05756 1087454004277 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1087454004278 dimer interface [polypeptide binding]; other site 1087454004279 pyridoxal binding site [chemical binding]; other site 1087454004280 ATP binding site [chemical binding]; other site 1087454004281 Domain of unknown function DUF21; Region: DUF21; pfam01595 1087454004282 FOG: CBS domain [General function prediction only]; Region: COG0517 1087454004283 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1087454004284 Transporter associated domain; Region: CorC_HlyC; cl08393 1087454004285 metal-binding heat shock protein; Provisional; Region: PRK00016 1087454004286 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1087454004287 PhoH-like protein; Region: PhoH; pfam02562 1087454004288 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1087454004289 RNA methyltransferase, RsmE family; Region: TIGR00046 1087454004290 chaperone protein DnaJ; Provisional; Region: PRK14278 1087454004291 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1087454004292 HSP70 interaction site [polypeptide binding]; other site 1087454004293 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1087454004294 Zn binding sites [ion binding]; other site 1087454004295 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1087454004296 dimer interface [polypeptide binding]; other site 1087454004297 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1087454004298 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1087454004299 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1087454004300 von Willebrand factor; Region: vWF_A; pfam12450 1087454004301 HemN C-terminal domain; Region: HemN_C; pfam06969 1087454004302 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1087454004303 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1087454004304 acyl-activating enzyme (AAE) consensus motif; other site 1087454004305 putative AMP binding site [chemical binding]; other site 1087454004306 putative active site [active] 1087454004307 putative CoA binding site [chemical binding]; other site 1087454004308 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1087454004309 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1087454004310 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1087454004311 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1087454004312 active site 1087454004313 Zn binding site [ion binding]; other site 1087454004314 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1087454004315 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1087454004316 substrate binding pocket [chemical binding]; other site 1087454004317 catalytic triad [active] 1087454004318 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1087454004319 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1087454004320 active site 1087454004321 metal binding site [ion binding]; metal-binding site 1087454004322 nudix motif; other site 1087454004323 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1087454004324 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1087454004325 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1087454004326 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1087454004327 active site 1087454004328 BCCT family transporter; Region: BCCT; pfam02028 1087454004329 Predicted permeases [General function prediction only]; Region: COG0679 1087454004330 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1087454004331 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 1087454004332 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1087454004333 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087454004334 dimer interface [polypeptide binding]; other site 1087454004335 conserved gate region; other site 1087454004336 putative PBP binding loops; other site 1087454004337 ABC-ATPase subunit interface; other site 1087454004338 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1087454004339 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087454004340 dimer interface [polypeptide binding]; other site 1087454004341 conserved gate region; other site 1087454004342 putative PBP binding loops; other site 1087454004343 ABC-ATPase subunit interface; other site 1087454004344 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1087454004345 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1087454004346 Walker A/P-loop; other site 1087454004347 ATP binding site [chemical binding]; other site 1087454004348 Q-loop/lid; other site 1087454004349 ABC transporter signature motif; other site 1087454004350 Walker B; other site 1087454004351 D-loop; other site 1087454004352 H-loop/switch region; other site 1087454004353 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1087454004354 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1087454004355 Walker A/P-loop; other site 1087454004356 ATP binding site [chemical binding]; other site 1087454004357 Q-loop/lid; other site 1087454004358 ABC transporter signature motif; other site 1087454004359 Walker B; other site 1087454004360 D-loop; other site 1087454004361 H-loop/switch region; other site 1087454004362 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1087454004363 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1087454004364 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1087454004365 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1087454004366 catalytic residue [active] 1087454004367 Sulphur transport; Region: Sulf_transp; pfam04143 1087454004368 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1087454004369 CPxP motif; other site 1087454004370 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1087454004371 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 1087454004372 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1087454004373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1087454004374 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1087454004375 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1087454004376 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087454004377 putative substrate translocation pore; other site 1087454004378 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1087454004379 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1087454004380 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1087454004381 thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277 1087454004382 Walker A/P-loop; other site 1087454004383 ATP binding site [chemical binding]; other site 1087454004384 Q-loop/lid; other site 1087454004385 ABC transporter signature motif; other site 1087454004386 Walker B; other site 1087454004387 D-loop; other site 1087454004388 H-loop/switch region; other site 1087454004389 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1087454004390 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1087454004391 Walker A/P-loop; other site 1087454004392 ATP binding site [chemical binding]; other site 1087454004393 Q-loop/lid; other site 1087454004394 ABC transporter signature motif; other site 1087454004395 Walker B; other site 1087454004396 D-loop; other site 1087454004397 H-loop/switch region; other site 1087454004398 GTP-binding protein LepA; Provisional; Region: PRK05433 1087454004399 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1087454004400 G1 box; other site 1087454004401 putative GEF interaction site [polypeptide binding]; other site 1087454004402 GTP/Mg2+ binding site [chemical binding]; other site 1087454004403 Switch I region; other site 1087454004404 G2 box; other site 1087454004405 G3 box; other site 1087454004406 Switch II region; other site 1087454004407 G4 box; other site 1087454004408 G5 box; other site 1087454004409 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1087454004410 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1087454004411 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1087454004412 PemK-like protein; Region: PemK; pfam02452 1087454004413 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1087454004414 LysE type translocator; Region: LysE; cl00565 1087454004415 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1087454004416 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1087454004417 hypothetical protein; Validated; Region: PRK05629 1087454004418 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1087454004419 Competence protein; Region: Competence; pfam03772 1087454004420 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 1087454004421 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1087454004422 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1087454004423 catalytic core [active] 1087454004424 Oligomerisation domain; Region: Oligomerisation; pfam02410 1087454004425 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1087454004426 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1087454004427 active site 1087454004428 (T/H)XGH motif; other site 1087454004429 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1087454004430 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1087454004431 putative catalytic cysteine [active] 1087454004432 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 1087454004433 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1087454004434 putative ligand binding site [chemical binding]; other site 1087454004435 putative NAD binding site [chemical binding]; other site 1087454004436 catalytic site [active] 1087454004437 Predicted permease [General function prediction only]; Region: COG2985 1087454004438 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1087454004439 TrkA-C domain; Region: TrkA_C; pfam02080 1087454004440 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 1087454004441 gamma-glutamyl kinase; Provisional; Region: PRK05429 1087454004442 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1087454004443 nucleotide binding site [chemical binding]; other site 1087454004444 homotetrameric interface [polypeptide binding]; other site 1087454004445 putative phosphate binding site [ion binding]; other site 1087454004446 putative allosteric binding site; other site 1087454004447 PUA domain; Region: PUA; pfam01472 1087454004448 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1087454004449 GTP1/OBG; Region: GTP1_OBG; pfam01018 1087454004450 Obg GTPase; Region: Obg; cd01898 1087454004451 G1 box; other site 1087454004452 GTP/Mg2+ binding site [chemical binding]; other site 1087454004453 Switch I region; other site 1087454004454 G2 box; other site 1087454004455 G3 box; other site 1087454004456 Switch II region; other site 1087454004457 G4 box; other site 1087454004458 G5 box; other site 1087454004459 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1087454004460 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1087454004461 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1087454004462 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1087454004463 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1087454004464 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1087454004465 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1087454004466 homodimer interface [polypeptide binding]; other site 1087454004467 oligonucleotide binding site [chemical binding]; other site 1087454004468 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1087454004469 active site 1087454004470 multimer interface [polypeptide binding]; other site 1087454004471 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1087454004472 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1087454004473 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1087454004474 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1087454004475 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1087454004476 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1087454004477 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1087454004478 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1087454004479 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1087454004480 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1087454004481 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1087454004482 active site 1087454004483 KMSKS motif; other site 1087454004484 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1087454004485 tRNA binding surface [nucleotide binding]; other site 1087454004486 anticodon binding site; other site 1087454004487 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1087454004488 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1087454004489 malate dehydrogenase; Provisional; Region: PRK05442 1087454004490 NAD(P) binding site [chemical binding]; other site 1087454004491 dimer interface [polypeptide binding]; other site 1087454004492 malate binding site [chemical binding]; other site 1087454004493 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1087454004494 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1087454004495 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1087454004496 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1087454004497 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1087454004498 Walker A motif; other site 1087454004499 ATP binding site [chemical binding]; other site 1087454004500 Walker B motif; other site 1087454004501 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1087454004502 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1087454004503 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1087454004504 glutamine binding [chemical binding]; other site 1087454004505 catalytic triad [active] 1087454004506 hypothetical protein; Validated; Region: PRK09070 1087454004507 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1087454004508 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1087454004509 Aminotransferase class IV; Region: Aminotran_4; pfam01063 1087454004510 substrate-cofactor binding pocket; other site 1087454004511 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1087454004512 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1087454004513 oligomer interface [polypeptide binding]; other site 1087454004514 active site residues [active] 1087454004515 Clp protease; Region: CLP_protease; pfam00574 1087454004516 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1087454004517 oligomer interface [polypeptide binding]; other site 1087454004518 active site residues [active] 1087454004519 trigger factor; Provisional; Region: tig; PRK01490 1087454004520 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1087454004521 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1087454004522 Pirin-related protein [General function prediction only]; Region: COG1741 1087454004523 Pirin; Region: Pirin; pfam02678 1087454004524 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1087454004525 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1087454004526 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1087454004527 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1087454004528 catalytic residues [active] 1087454004529 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1087454004530 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1087454004531 apolar tunnel; other site 1087454004532 heme binding site [chemical binding]; other site 1087454004533 dimerization interface [polypeptide binding]; other site 1087454004534 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1087454004535 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1087454004536 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1087454004537 active site 1087454004538 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1087454004539 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1087454004540 Walker A/P-loop; other site 1087454004541 ATP binding site [chemical binding]; other site 1087454004542 Q-loop/lid; other site 1087454004543 ABC transporter signature motif; other site 1087454004544 Walker B; other site 1087454004545 D-loop; other site 1087454004546 H-loop/switch region; other site 1087454004547 ABC transporter; Region: ABC_tran_2; pfam12848 1087454004548 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1087454004549 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1087454004550 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1087454004551 dimer interface [polypeptide binding]; other site 1087454004552 ssDNA binding site [nucleotide binding]; other site 1087454004553 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1087454004554 YcaO-like family; Region: YcaO; pfam02624 1087454004555 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1087454004556 NADPH bind site [chemical binding]; other site 1087454004557 Nitroreductase family; Region: Nitroreductase; pfam00881 1087454004558 dimer interface [polypeptide binding]; other site 1087454004559 SpaB C-terminal domain; Region: SpaB_C; pfam14028 1087454004560 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 1087454004561 YcaO-like family; Region: YcaO; pfam02624 1087454004562 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1087454004563 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1087454004564 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1087454004565 Walker A/P-loop; other site 1087454004566 ATP binding site [chemical binding]; other site 1087454004567 Q-loop/lid; other site 1087454004568 ABC transporter signature motif; other site 1087454004569 Walker B; other site 1087454004570 D-loop; other site 1087454004571 H-loop/switch region; other site 1087454004572 Copper resistance protein D; Region: CopD; pfam05425 1087454004573 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1087454004574 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1087454004575 Carbon starvation protein CstA; Region: CstA; pfam02554 1087454004576 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1087454004577 Protein of unknown function (DUF466); Region: DUF466; pfam04328 1087454004578 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 1087454004579 active site 1087454004580 catalytic triad [active] 1087454004581 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1087454004582 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1087454004583 NADP binding site [chemical binding]; other site 1087454004584 dimer interface [polypeptide binding]; other site 1087454004585 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1087454004586 classical (c) SDRs; Region: SDR_c; cd05233 1087454004587 NAD(P) binding site [chemical binding]; other site 1087454004588 active site 1087454004589 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1087454004590 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1087454004591 catalytic site [active] 1087454004592 putative active site [active] 1087454004593 putative substrate binding site [chemical binding]; other site 1087454004594 dimer interface [polypeptide binding]; other site 1087454004595 N-acetylneuraminate lyase; Region: nanA; TIGR00683 1087454004596 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1087454004597 inhibitor site; inhibition site 1087454004598 active site 1087454004599 dimer interface [polypeptide binding]; other site 1087454004600 catalytic residue [active] 1087454004601 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 1087454004602 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1087454004603 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1087454004604 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1087454004605 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1087454004606 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1087454004607 NAD(P) binding site [chemical binding]; other site 1087454004608 substrate binding site [chemical binding]; other site 1087454004609 dimer interface [polypeptide binding]; other site 1087454004610 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1087454004611 Isochorismatase family; Region: Isochorismatase; pfam00857 1087454004612 catalytic triad [active] 1087454004613 metal binding site [ion binding]; metal-binding site 1087454004614 conserved cis-peptide bond; other site 1087454004615 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1087454004616 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1087454004617 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1087454004618 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1087454004619 catalytic triad [active] 1087454004620 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1087454004621 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1087454004622 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1087454004623 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1087454004624 Histidine kinase; Region: HisKA_3; pfam07730 1087454004625 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1087454004626 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1087454004627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1087454004628 active site 1087454004629 phosphorylation site [posttranslational modification] 1087454004630 intermolecular recognition site; other site 1087454004631 dimerization interface [polypeptide binding]; other site 1087454004632 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1087454004633 DNA binding residues [nucleotide binding] 1087454004634 dimerization interface [polypeptide binding]; other site 1087454004635 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1087454004636 CAAX protease self-immunity; Region: Abi; pfam02517 1087454004637 Glucitol operon activator protein (GutM); Region: GutM; cl01890 1087454004638 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1087454004639 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1087454004640 active site 1087454004641 dimerization interface [polypeptide binding]; other site 1087454004642 ribonuclease PH; Reviewed; Region: rph; PRK00173 1087454004643 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1087454004644 hexamer interface [polypeptide binding]; other site 1087454004645 active site 1087454004646 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1087454004647 glutamate racemase; Provisional; Region: PRK00865 1087454004648 Rhomboid family; Region: Rhomboid; pfam01694 1087454004649 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1087454004650 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1087454004651 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1087454004652 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1087454004653 active site 1087454004654 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1087454004655 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1087454004656 ATP binding site [chemical binding]; other site 1087454004657 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1087454004658 putative Mg++ binding site [ion binding]; other site 1087454004659 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1087454004660 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1087454004661 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1087454004662 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1087454004663 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1087454004664 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1087454004665 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1087454004666 motif II; other site 1087454004667 Homeodomain-like domain; Region: HTH_23; pfam13384 1087454004668 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1087454004669 Helix-turn-helix domain; Region: HTH_28; pfam13518 1087454004670 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1087454004671 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1087454004672 D-pathway; other site 1087454004673 Putative ubiquinol binding site [chemical binding]; other site 1087454004674 Low-spin heme (heme b) binding site [chemical binding]; other site 1087454004675 Putative water exit pathway; other site 1087454004676 Binuclear center (heme o3/CuB) [ion binding]; other site 1087454004677 K-pathway; other site 1087454004678 Putative proton exit pathway; other site 1087454004679 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1087454004680 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1087454004681 dimer interface [polypeptide binding]; other site 1087454004682 putative radical transfer pathway; other site 1087454004683 diiron center [ion binding]; other site 1087454004684 tyrosyl radical; other site 1087454004685 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1087454004686 Ferritin-like domain; Region: Ferritin; pfam00210 1087454004687 ferroxidase diiron center [ion binding]; other site 1087454004688 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1087454004689 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1087454004690 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1087454004691 active site 1087454004692 dimer interface [polypeptide binding]; other site 1087454004693 catalytic residues [active] 1087454004694 effector binding site; other site 1087454004695 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1087454004696 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1087454004697 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1087454004698 catalytic residues [active] 1087454004699 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1087454004700 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1087454004701 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1087454004702 homodimer interface [polypeptide binding]; other site 1087454004703 NAD binding pocket [chemical binding]; other site 1087454004704 ATP binding pocket [chemical binding]; other site 1087454004705 Mg binding site [ion binding]; other site 1087454004706 active-site loop [active] 1087454004707 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1087454004708 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1087454004709 dimerization interface [polypeptide binding]; other site 1087454004710 putative DNA binding site [nucleotide binding]; other site 1087454004711 putative Zn2+ binding site [ion binding]; other site 1087454004712 Thioredoxin; Region: Thioredoxin_4; cl17273 1087454004713 Predicted membrane protein [Function unknown]; Region: COG2259 1087454004714 phosphoglucomutase; Validated; Region: PRK07564 1087454004715 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1087454004716 active site 1087454004717 substrate binding site [chemical binding]; other site 1087454004718 metal binding site [ion binding]; metal-binding site 1087454004719 camphor resistance protein CrcB; Provisional; Region: ccrB; PRK00134 1087454004720 CrcB-like protein; Region: CRCB; pfam02537 1087454004721 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1087454004722 FtsX-like permease family; Region: FtsX; pfam02687 1087454004723 FtsX-like permease family; Region: FtsX; pfam02687 1087454004724 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1087454004725 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1087454004726 Walker A/P-loop; other site 1087454004727 ATP binding site [chemical binding]; other site 1087454004728 Q-loop/lid; other site 1087454004729 ABC transporter signature motif; other site 1087454004730 Walker B; other site 1087454004731 D-loop; other site 1087454004732 H-loop/switch region; other site 1087454004733 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1087454004734 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 1087454004735 active site 1087454004736 hinge; other site 1087454004737 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1087454004738 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1087454004739 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1087454004740 DNA binding residues [nucleotide binding] 1087454004741 dimerization interface [polypeptide binding]; other site 1087454004742 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1087454004743 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1087454004744 dimer interface [polypeptide binding]; other site 1087454004745 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1087454004746 catalytic residue [active] 1087454004747 serine O-acetyltransferase; Region: cysE; TIGR01172 1087454004748 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1087454004749 trimer interface [polypeptide binding]; other site 1087454004750 active site 1087454004751 substrate binding site [chemical binding]; other site 1087454004752 CoA binding site [chemical binding]; other site 1087454004753 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1087454004754 Coenzyme A binding pocket [chemical binding]; other site 1087454004755 Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171 1087454004756 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1087454004757 putative active site [active] 1087454004758 metal binding site [ion binding]; metal-binding site 1087454004759 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1087454004760 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1087454004761 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1087454004762 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1087454004763 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1087454004764 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1087454004765 Walker A/P-loop; other site 1087454004766 ATP binding site [chemical binding]; other site 1087454004767 Q-loop/lid; other site 1087454004768 ABC transporter signature motif; other site 1087454004769 Walker B; other site 1087454004770 D-loop; other site 1087454004771 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1087454004772 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1087454004773 Walker A/P-loop; other site 1087454004774 ATP binding site [chemical binding]; other site 1087454004775 Q-loop/lid; other site 1087454004776 ABC transporter signature motif; other site 1087454004777 Walker B; other site 1087454004778 D-loop; other site 1087454004779 H-loop/switch region; other site 1087454004780 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1087454004781 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1087454004782 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1087454004783 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1087454004784 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1087454004785 FMN binding site [chemical binding]; other site 1087454004786 active site 1087454004787 catalytic residues [active] 1087454004788 substrate binding site [chemical binding]; other site 1087454004789 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1087454004790 PhoU domain; Region: PhoU; pfam01895 1087454004791 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1087454004792 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1087454004793 Walker A/P-loop; other site 1087454004794 ATP binding site [chemical binding]; other site 1087454004795 Q-loop/lid; other site 1087454004796 ABC transporter signature motif; other site 1087454004797 Walker B; other site 1087454004798 D-loop; other site 1087454004799 H-loop/switch region; other site 1087454004800 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1087454004801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087454004802 dimer interface [polypeptide binding]; other site 1087454004803 conserved gate region; other site 1087454004804 putative PBP binding loops; other site 1087454004805 ABC-ATPase subunit interface; other site 1087454004806 PBP superfamily domain; Region: PBP_like_2; cl17296 1087454004807 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1087454004808 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1087454004809 Coenzyme A binding pocket [chemical binding]; other site 1087454004810 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1087454004811 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1087454004812 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1087454004813 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1087454004814 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1087454004815 heme-binding site [chemical binding]; other site 1087454004816 4-amino-4-deoxychorismate lyase; Provisional; Region: PRK07849 1087454004817 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1087454004818 homodimer interface [polypeptide binding]; other site 1087454004819 substrate-cofactor binding pocket; other site 1087454004820 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1087454004821 catalytic residue [active] 1087454004822 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1087454004823 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1087454004824 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1087454004825 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1087454004826 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1087454004827 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1087454004828 dimerization interface [polypeptide binding]; other site 1087454004829 putative ATP binding site [chemical binding]; other site 1087454004830 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1087454004831 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1087454004832 active site 1087454004833 tetramer interface [polypeptide binding]; other site 1087454004834 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1087454004835 active site 1087454004836 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1087454004837 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1087454004838 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1087454004839 dimer interface [polypeptide binding]; other site 1087454004840 putative radical transfer pathway; other site 1087454004841 diiron center [ion binding]; other site 1087454004842 tyrosyl radical; other site 1087454004843 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1087454004844 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1087454004845 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1087454004846 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1087454004847 dimerization interface [polypeptide binding]; other site 1087454004848 ATP binding site [chemical binding]; other site 1087454004849 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1087454004850 dimerization interface [polypeptide binding]; other site 1087454004851 ATP binding site [chemical binding]; other site 1087454004852 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1087454004853 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1087454004854 putative active site [active] 1087454004855 catalytic triad [active] 1087454004856 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1087454004857 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1087454004858 catalytic residues [active] 1087454004859 dimer interface [polypeptide binding]; other site 1087454004860 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1087454004861 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1087454004862 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1087454004863 ATP binding site [chemical binding]; other site 1087454004864 active site 1087454004865 substrate binding site [chemical binding]; other site 1087454004866 adenylosuccinate lyase; Region: purB; TIGR00928 1087454004867 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1087454004868 tetramer interface [polypeptide binding]; other site 1087454004869 TrkA-N domain; Region: TrkA_N; pfam02254 1087454004870 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1087454004871 TrkA-C domain; Region: TrkA_C; pfam02080 1087454004872 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1087454004873 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1087454004874 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1087454004875 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1087454004876 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1087454004877 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1087454004878 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1087454004879 nucleotide binding site/active site [active] 1087454004880 HIT family signature motif; other site 1087454004881 catalytic residue [active] 1087454004882 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1087454004883 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1087454004884 dimerization interface [polypeptide binding]; other site 1087454004885 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1087454004886 dimer interface [polypeptide binding]; other site 1087454004887 phosphorylation site [posttranslational modification] 1087454004888 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1087454004889 ATP binding site [chemical binding]; other site 1087454004890 Mg2+ binding site [ion binding]; other site 1087454004891 G-X-G motif; other site 1087454004892 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1087454004893 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1087454004894 active site 1087454004895 phosphorylation site [posttranslational modification] 1087454004896 intermolecular recognition site; other site 1087454004897 dimerization interface [polypeptide binding]; other site 1087454004898 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1087454004899 DNA binding site [nucleotide binding] 1087454004900 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1087454004901 Predicted esterase [General function prediction only]; Region: COG0627 1087454004902 S-formylglutathione hydrolase; Region: PLN02442 1087454004903 xanthine permease; Region: pbuX; TIGR03173 1087454004904 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 1087454004905 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1087454004906 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1087454004907 putative active site [active] 1087454004908 pyruvate dehydrogenase; Provisional; Region: PRK06546 1087454004909 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1087454004910 PYR/PP interface [polypeptide binding]; other site 1087454004911 tetramer interface [polypeptide binding]; other site 1087454004912 dimer interface [polypeptide binding]; other site 1087454004913 TPP binding site [chemical binding]; other site 1087454004914 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1087454004915 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1087454004916 TPP-binding site [chemical binding]; other site 1087454004917 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1087454004918 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1087454004919 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1087454004920 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1087454004921 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1087454004922 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1087454004923 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1087454004924 active site 1087454004925 homotetramer interface [polypeptide binding]; other site 1087454004926 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1087454004927 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1087454004928 DNA binding site [nucleotide binding] 1087454004929 domain linker motif; other site 1087454004930 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 1087454004931 putative dimerization interface [polypeptide binding]; other site 1087454004932 putative ligand binding site [chemical binding]; other site 1087454004933 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1087454004934 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1087454004935 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1087454004936 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1087454004937 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1087454004938 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1087454004939 active site 1087454004940 HIGH motif; other site 1087454004941 nucleotide binding site [chemical binding]; other site 1087454004942 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1087454004943 KMSKS motif; other site 1087454004944 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1087454004945 tRNA binding surface [nucleotide binding]; other site 1087454004946 anticodon binding site; other site 1087454004947 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1087454004948 homotrimer interaction site [polypeptide binding]; other site 1087454004949 zinc binding site [ion binding]; other site 1087454004950 CDP-binding sites; other site 1087454004951 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1087454004952 substrate binding site; other site 1087454004953 dimer interface; other site 1087454004954 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1087454004955 DNA repair protein RadA; Provisional; Region: PRK11823 1087454004956 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1087454004957 ATP binding site [chemical binding]; other site 1087454004958 Walker B motif; other site 1087454004959 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1087454004960 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1087454004961 active site clefts [active] 1087454004962 zinc binding site [ion binding]; other site 1087454004963 dimer interface [polypeptide binding]; other site 1087454004964 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1087454004965 endonuclease III; Region: ENDO3c; smart00478 1087454004966 minor groove reading motif; other site 1087454004967 helix-hairpin-helix signature motif; other site 1087454004968 substrate binding pocket [chemical binding]; other site 1087454004969 active site 1087454004970 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1087454004971 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 1087454004972 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1087454004973 Clp amino terminal domain; Region: Clp_N; pfam02861 1087454004974 Clp amino terminal domain; Region: Clp_N; pfam02861 1087454004975 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1087454004976 Walker A motif; other site 1087454004977 ATP binding site [chemical binding]; other site 1087454004978 Walker B motif; other site 1087454004979 arginine finger; other site 1087454004980 UvrB/uvrC motif; Region: UVR; pfam02151 1087454004981 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1087454004982 Walker A motif; other site 1087454004983 ATP binding site [chemical binding]; other site 1087454004984 Walker B motif; other site 1087454004985 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1087454004986 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087454004987 putative substrate translocation pore; other site 1087454004988 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1087454004989 active site 1087454004990 tetramer interface [polypeptide binding]; other site 1087454004991 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1087454004992 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1087454004993 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1087454004994 CAAX protease self-immunity; Region: Abi; pfam02517 1087454004995 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1087454004996 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1087454004997 dimer interface [polypeptide binding]; other site 1087454004998 putative anticodon binding site; other site 1087454004999 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1087454005000 motif 1; other site 1087454005001 dimer interface [polypeptide binding]; other site 1087454005002 active site 1087454005003 motif 2; other site 1087454005004 motif 3; other site 1087454005005 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1087454005006 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 1087454005007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 1087454005008 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1087454005009 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1087454005010 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1087454005011 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1087454005012 NAD(P) binding site [chemical binding]; other site 1087454005013 catalytic residues [active] 1087454005014 BCCT family transporter; Region: BCCT; cl00569 1087454005015 choline dehydrogenase; Validated; Region: PRK02106 1087454005016 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1087454005017 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1087454005018 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1087454005019 active site 1087454005020 nucleotide binding site [chemical binding]; other site 1087454005021 HIGH motif; other site 1087454005022 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1087454005023 KMSKS motif; other site 1087454005024 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1087454005025 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1087454005026 catalytic center binding site [active] 1087454005027 ATP binding site [chemical binding]; other site 1087454005028 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1087454005029 homooctamer interface [polypeptide binding]; other site 1087454005030 active site 1087454005031 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1087454005032 dihydropteroate synthase; Region: DHPS; TIGR01496 1087454005033 substrate binding pocket [chemical binding]; other site 1087454005034 dimer interface [polypeptide binding]; other site 1087454005035 inhibitor binding site; inhibition site 1087454005036 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1087454005037 GTP cyclohydrolase I; Provisional; Region: PLN03044 1087454005038 homodecamer interface [polypeptide binding]; other site 1087454005039 active site 1087454005040 putative catalytic site residues [active] 1087454005041 zinc binding site [ion binding]; other site 1087454005042 GTP-CH-I/GFRP interaction surface; other site 1087454005043 FtsH Extracellular; Region: FtsH_ext; pfam06480 1087454005044 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1087454005045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1087454005046 Walker A motif; other site 1087454005047 ATP binding site [chemical binding]; other site 1087454005048 Walker B motif; other site 1087454005049 arginine finger; other site 1087454005050 Peptidase family M41; Region: Peptidase_M41; pfam01434 1087454005051 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1087454005052 active site 1087454005053 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1087454005054 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1087454005055 Ligand Binding Site [chemical binding]; other site 1087454005056 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1087454005057 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1087454005058 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1087454005059 dimer interface [polypeptide binding]; other site 1087454005060 substrate binding site [chemical binding]; other site 1087454005061 metal binding sites [ion binding]; metal-binding site 1087454005062 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1087454005063 active site residue [active] 1087454005064 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1087454005065 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1087454005066 Secretory lipase; Region: LIP; pfam03583 1087454005067 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1087454005068 MarR family; Region: MarR_2; pfam12802 1087454005069 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1087454005070 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1087454005071 acyl-activating enzyme (AAE) consensus motif; other site 1087454005072 AMP binding site [chemical binding]; other site 1087454005073 active site 1087454005074 CoA binding site [chemical binding]; other site 1087454005075 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1087454005076 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 1087454005077 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1087454005078 putative trimer interface [polypeptide binding]; other site 1087454005079 putative CoA binding site [chemical binding]; other site 1087454005080 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1087454005081 putative trimer interface [polypeptide binding]; other site 1087454005082 putative CoA binding site [chemical binding]; other site 1087454005083 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1087454005084 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1087454005085 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1087454005086 ring oligomerisation interface [polypeptide binding]; other site 1087454005087 ATP/Mg binding site [chemical binding]; other site 1087454005088 stacking interactions; other site 1087454005089 hinge regions; other site 1087454005090 hypothetical protein; Provisional; Region: PRK07907 1087454005091 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1087454005092 active site 1087454005093 metal binding site [ion binding]; metal-binding site 1087454005094 dimer interface [polypeptide binding]; other site 1087454005095 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 1087454005096 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1087454005097 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1087454005098 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1087454005099 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1087454005100 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 1087454005101 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 1087454005102 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1087454005103 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1087454005104 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948 1087454005105 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 1087454005106 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1087454005107 carboxylate-amine ligase; Provisional; Region: PRK13517 1087454005108 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1087454005109 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1087454005110 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1087454005111 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1087454005112 active site 1087454005113 catalytic residues [active] 1087454005114 metal binding site [ion binding]; metal-binding site 1087454005115 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1087454005116 Coenzyme A binding pocket [chemical binding]; other site 1087454005117 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1087454005118 putative catalytic site [active] 1087454005119 putative phosphate binding site [ion binding]; other site 1087454005120 active site 1087454005121 metal binding site A [ion binding]; metal-binding site 1087454005122 DNA binding site [nucleotide binding] 1087454005123 putative AP binding site [nucleotide binding]; other site 1087454005124 putative metal binding site B [ion binding]; other site 1087454005125 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1087454005126 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1087454005127 putative active site [active] 1087454005128 catalytic site [active] 1087454005129 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1087454005130 putative active site [active] 1087454005131 catalytic site [active] 1087454005132 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1087454005133 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1087454005134 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1087454005135 Walker A/P-loop; other site 1087454005136 ATP binding site [chemical binding]; other site 1087454005137 Q-loop/lid; other site 1087454005138 ABC transporter signature motif; other site 1087454005139 Walker B; other site 1087454005140 D-loop; other site 1087454005141 H-loop/switch region; other site 1087454005142 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1087454005143 nudix motif; other site 1087454005144 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1087454005145 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1087454005146 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1087454005147 substrate binding pocket [chemical binding]; other site 1087454005148 membrane-bound complex binding site; other site 1087454005149 hinge residues; other site 1087454005150 propionate/acetate kinase; Provisional; Region: PRK12379 1087454005151 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1087454005152 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1087454005153 ferredoxin-NADP+ reductase; Region: PLN02852 1087454005154 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1087454005155 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1087454005156 Coenzyme A binding pocket [chemical binding]; other site 1087454005157 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1087454005158 active site 1087454005159 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1087454005160 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1087454005161 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1087454005162 active site 1087454005163 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1087454005164 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1087454005165 catalytic residues [active] 1087454005166 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1087454005167 ResB-like family; Region: ResB; pfam05140 1087454005168 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1087454005169 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1087454005170 TPR motif; other site 1087454005171 TPR repeat; Region: TPR_11; pfam13414 1087454005172 binding surface 1087454005173 Cytochrome c552; Region: Cytochrom_C552; pfam02335 1087454005174 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1087454005175 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 1087454005176 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1087454005177 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1087454005178 GDP-binding site [chemical binding]; other site 1087454005179 ACT binding site; other site 1087454005180 IMP binding site; other site 1087454005181 Predicted membrane protein [Function unknown]; Region: COG4129 1087454005182 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1087454005183 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1087454005184 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1087454005185 Walker A/P-loop; other site 1087454005186 ATP binding site [chemical binding]; other site 1087454005187 Q-loop/lid; other site 1087454005188 ABC transporter signature motif; other site 1087454005189 Walker B; other site 1087454005190 D-loop; other site 1087454005191 H-loop/switch region; other site 1087454005192 Predicted transcriptional regulators [Transcription]; Region: COG1695 1087454005193 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1087454005194 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1087454005195 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1087454005196 active site 1087454005197 intersubunit interface [polypeptide binding]; other site 1087454005198 zinc binding site [ion binding]; other site 1087454005199 Na+ binding site [ion binding]; other site 1087454005200 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 1087454005201 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1087454005202 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1087454005203 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1087454005204 active site 1087454005205 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1087454005206 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1087454005207 active site residue [active] 1087454005208 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1087454005209 active site residue [active] 1087454005210 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1087454005211 Gram positive anchor; Region: Gram_pos_anchor; cl15427 1087454005212 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1087454005213 active site 1087454005214 catalytic site [active] 1087454005215 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1087454005216 Clp amino terminal domain; Region: Clp_N; pfam02861 1087454005217 Clp amino terminal domain; Region: Clp_N; pfam02861 1087454005218 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1087454005219 Walker A motif; other site 1087454005220 ATP binding site [chemical binding]; other site 1087454005221 Walker B motif; other site 1087454005222 arginine finger; other site 1087454005223 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1087454005224 Walker A motif; other site 1087454005225 ATP binding site [chemical binding]; other site 1087454005226 Walker B motif; other site 1087454005227 arginine finger; other site 1087454005228 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1087454005229 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1087454005230 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1087454005231 Walker A/P-loop; other site 1087454005232 ATP binding site [chemical binding]; other site 1087454005233 Q-loop/lid; other site 1087454005234 ABC transporter signature motif; other site 1087454005235 Walker B; other site 1087454005236 D-loop; other site 1087454005237 H-loop/switch region; other site 1087454005238 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 1087454005239 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1087454005240 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 1087454005241 FAD binding pocket [chemical binding]; other site 1087454005242 conserved FAD binding motif [chemical binding]; other site 1087454005243 phosphate binding motif [ion binding]; other site 1087454005244 beta-alpha-beta structure motif; other site 1087454005245 NAD binding pocket [chemical binding]; other site 1087454005246 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1087454005247 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1087454005248 Walker A/P-loop; other site 1087454005249 ATP binding site [chemical binding]; other site 1087454005250 Q-loop/lid; other site 1087454005251 ABC transporter signature motif; other site 1087454005252 Walker B; other site 1087454005253 D-loop; other site 1087454005254 H-loop/switch region; other site 1087454005255 HlyD family secretion protein; Region: HlyD_3; pfam13437 1087454005256 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1087454005257 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1087454005258 putative active site [active] 1087454005259 catalytic triad [active] 1087454005260 putative dimer interface [polypeptide binding]; other site 1087454005261 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1087454005262 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1087454005263 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1087454005264 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1087454005265 NAD binding site [chemical binding]; other site 1087454005266 substrate binding site [chemical binding]; other site 1087454005267 catalytic Zn binding site [ion binding]; other site 1087454005268 tetramer interface [polypeptide binding]; other site 1087454005269 structural Zn binding site [ion binding]; other site 1087454005270 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1087454005271 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1087454005272 DNA binding residues [nucleotide binding] 1087454005273 chaperone protein DnaJ; Provisional; Region: PRK14279 1087454005274 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1087454005275 HSP70 interaction site [polypeptide binding]; other site 1087454005276 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1087454005277 Zn binding sites [ion binding]; other site 1087454005278 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1087454005279 dimer interface [polypeptide binding]; other site 1087454005280 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1087454005281 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1087454005282 dimer interface [polypeptide binding]; other site 1087454005283 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1087454005284 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1087454005285 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1087454005286 nucleotide binding site [chemical binding]; other site 1087454005287 NEF interaction site [polypeptide binding]; other site 1087454005288 SBD interface [polypeptide binding]; other site 1087454005289 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1087454005290 active site 1087454005291 catalytic site [active] 1087454005292 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1087454005293 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 1087454005294 Walker A/P-loop; other site 1087454005295 ATP binding site [chemical binding]; other site 1087454005296 Q-loop/lid; other site 1087454005297 ABC transporter signature motif; other site 1087454005298 Walker B; other site 1087454005299 D-loop; other site 1087454005300 H-loop/switch region; other site 1087454005301 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1087454005302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087454005303 dimer interface [polypeptide binding]; other site 1087454005304 conserved gate region; other site 1087454005305 putative PBP binding loops; other site 1087454005306 ABC-ATPase subunit interface; other site 1087454005307 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1087454005308 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1087454005309 adrenodoxin reductase; Provisional; Region: PTZ00188 1087454005310 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1087454005311 4Fe-4S binding domain; Region: Fer4; cl02805 1087454005312 4Fe-4S binding domain; Region: Fer4; pfam00037 1087454005313 Cysteine-rich domain; Region: CCG; pfam02754 1087454005314 Cysteine-rich domain; Region: CCG; pfam02754 1087454005315 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1087454005316 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1087454005317 dimerization interface [polypeptide binding]; other site 1087454005318 putative DNA binding site [nucleotide binding]; other site 1087454005319 putative Zn2+ binding site [ion binding]; other site 1087454005320 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1087454005321 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1087454005322 Walker A/P-loop; other site 1087454005323 ATP binding site [chemical binding]; other site 1087454005324 Q-loop/lid; other site 1087454005325 ABC transporter signature motif; other site 1087454005326 Walker B; other site 1087454005327 D-loop; other site 1087454005328 H-loop/switch region; other site 1087454005329 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1087454005330 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1087454005331 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1087454005332 putative PBP binding regions; other site 1087454005333 ABC-ATPase subunit interface; other site 1087454005334 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1087454005335 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1087454005336 intersubunit interface [polypeptide binding]; other site 1087454005337 UreD urease accessory protein; Region: UreD; cl00530 1087454005338 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1087454005339 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1087454005340 UreF; Region: UreF; pfam01730 1087454005341 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1087454005342 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1087454005343 dimer interface [polypeptide binding]; other site 1087454005344 catalytic residues [active] 1087454005345 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1087454005346 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1087454005347 subunit interactions [polypeptide binding]; other site 1087454005348 active site 1087454005349 flap region; other site 1087454005350 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1087454005351 gamma-beta subunit interface [polypeptide binding]; other site 1087454005352 alpha-beta subunit interface [polypeptide binding]; other site 1087454005353 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1087454005354 alpha-gamma subunit interface [polypeptide binding]; other site 1087454005355 beta-gamma subunit interface [polypeptide binding]; other site 1087454005356 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1087454005357 EamA-like transporter family; Region: EamA; pfam00892 1087454005358 EamA-like transporter family; Region: EamA; pfam00892 1087454005359 aminotransferase AlaT; Validated; Region: PRK09265 1087454005360 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1087454005361 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1087454005362 homodimer interface [polypeptide binding]; other site 1087454005363 catalytic residue [active] 1087454005364 YibE/F-like protein; Region: YibE_F; pfam07907 1087454005365 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 1087454005366 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1087454005367 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1087454005368 dimer interface [polypeptide binding]; other site 1087454005369 putative anticodon binding site; other site 1087454005370 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1087454005371 motif 1; other site 1087454005372 dimer interface [polypeptide binding]; other site 1087454005373 active site 1087454005374 motif 2; other site 1087454005375 motif 3; other site 1087454005376 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1087454005377 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1087454005378 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1087454005379 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1087454005380 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1087454005381 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1087454005382 trimer interface [polypeptide binding]; other site 1087454005383 active site 1087454005384 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1087454005385 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1087454005386 NAD(P) binding site [chemical binding]; other site 1087454005387 catalytic residues [active] 1087454005388 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 1087454005389 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1087454005390 VanW like protein; Region: VanW; pfam04294 1087454005391 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1087454005392 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1087454005393 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1087454005394 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1087454005395 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1087454005396 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1087454005397 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1087454005398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1087454005399 S-adenosylmethionine binding site [chemical binding]; other site 1087454005400 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1087454005401 active site 1087454005402 substrate-binding site [chemical binding]; other site 1087454005403 metal-binding site [ion binding] 1087454005404 GTP binding site [chemical binding]; other site 1087454005405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1087454005406 S-adenosylmethionine binding site [chemical binding]; other site 1087454005407 LabA_like proteins; Region: LabA_like; cd06167 1087454005408 putative metal binding site [ion binding]; other site 1087454005409 Predicted integral membrane protein [Function unknown]; Region: COG0392 1087454005410 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1087454005411 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cl00323 1087454005412 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1087454005413 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1087454005414 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1087454005415 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1087454005416 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 1087454005417 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1087454005418 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1087454005419 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1087454005420 active site 1087454005421 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1087454005422 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1087454005423 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1087454005424 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1087454005425 acyl-activating enzyme (AAE) consensus motif; other site 1087454005426 active site 1087454005427 Cutinase; Region: Cutinase; pfam01083 1087454005428 Putative esterase; Region: Esterase; pfam00756 1087454005429 S-formylglutathione hydrolase; Region: PLN02442 1087454005430 LGFP repeat; Region: LGFP; pfam08310 1087454005431 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1087454005432 LGFP repeat; Region: LGFP; pfam08310 1087454005433 LGFP repeat; Region: LGFP; pfam08310 1087454005434 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1087454005435 Predicted esterase [General function prediction only]; Region: COG0627 1087454005436 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1087454005437 UbiA prenyltransferase family; Region: UbiA; pfam01040 1087454005438 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1087454005439 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1087454005440 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1087454005441 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1087454005442 Repair protein; Region: Repair_PSII; pfam04536 1087454005443 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1087454005444 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1087454005445 active site 1087454005446 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1087454005447 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1087454005448 active site 1087454005449 catalytic site [active] 1087454005450 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1087454005451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087454005452 putative substrate translocation pore; other site 1087454005453 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1087454005454 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1087454005455 UDP-galactopyranose mutase; Region: GLF; pfam03275 1087454005456 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1087454005457 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1087454005458 Walker A/P-loop; other site 1087454005459 ATP binding site [chemical binding]; other site 1087454005460 Q-loop/lid; other site 1087454005461 ABC transporter signature motif; other site 1087454005462 Walker B; other site 1087454005463 D-loop; other site 1087454005464 H-loop/switch region; other site 1087454005465 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1087454005466 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1087454005467 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1087454005468 putative PBP binding regions; other site 1087454005469 ABC-ATPase subunit interface; other site 1087454005470 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1087454005471 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1087454005472 putative binding site residues; other site 1087454005473 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1087454005474 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1087454005475 amidase catalytic site [active] 1087454005476 Zn binding residues [ion binding]; other site 1087454005477 substrate binding site [chemical binding]; other site 1087454005478 LGFP repeat; Region: LGFP; pfam08310 1087454005479 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1087454005480 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1087454005481 active site 1087454005482 motif I; other site 1087454005483 motif II; other site 1087454005484 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1087454005485 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1087454005486 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1087454005487 putative acyl-acceptor binding pocket; other site 1087454005488 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1087454005489 seryl-tRNA synthetase; Provisional; Region: PRK05431 1087454005490 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1087454005491 dimer interface [polypeptide binding]; other site 1087454005492 active site 1087454005493 motif 1; other site 1087454005494 motif 2; other site 1087454005495 motif 3; other site 1087454005496 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1087454005497 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1087454005498 DNA-binding site [nucleotide binding]; DNA binding site 1087454005499 UTRA domain; Region: UTRA; pfam07702 1087454005500 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1087454005501 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1087454005502 catalytic core [active] 1087454005503 Prephenate dehydratase; Region: PDT; pfam00800 1087454005504 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1087454005505 putative L-Phe binding site [chemical binding]; other site 1087454005506 Amidase; Region: Amidase; cl11426 1087454005507 CAAX protease self-immunity; Region: Abi; pfam02517 1087454005508 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1087454005509 Htaa; Region: HtaA; pfam04213 1087454005510 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1087454005511 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1087454005512 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1087454005513 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 1087454005514 putative active site [active] 1087454005515 catalytic site [active] 1087454005516 putative metal binding site [ion binding]; other site 1087454005517 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1087454005518 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1087454005519 Nucleoside recognition; Region: Gate; pfam07670 1087454005520 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1087454005521 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1087454005522 active site 1087454005523 catalytic motif [active] 1087454005524 Zn binding site [ion binding]; other site 1087454005525 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1087454005526 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1087454005527 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1087454005528 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1087454005529 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1087454005530 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1087454005531 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1087454005532 NAD binding site [chemical binding]; other site 1087454005533 dimer interface [polypeptide binding]; other site 1087454005534 substrate binding site [chemical binding]; other site 1087454005535 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1087454005536 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1087454005537 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1087454005538 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1087454005539 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1087454005540 Predicted flavoprotein [General function prediction only]; Region: COG0431 1087454005541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087454005542 putative substrate translocation pore; other site 1087454005543 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1087454005544 Abi-like protein; Region: Abi_2; pfam07751 1087454005545 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 1087454005546 homodimer interface [polypeptide binding]; other site 1087454005547 chemical substrate binding site [chemical binding]; other site 1087454005548 oligomer interface [polypeptide binding]; other site 1087454005549 metal binding site [ion binding]; metal-binding site 1087454005550 Lsr2; Region: Lsr2; pfam11774 1087454005551 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1087454005552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1087454005553 active site 1087454005554 phosphorylation site [posttranslational modification] 1087454005555 intermolecular recognition site; other site 1087454005556 dimerization interface [polypeptide binding]; other site 1087454005557 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1087454005558 DNA binding residues [nucleotide binding] 1087454005559 dimerization interface [polypeptide binding]; other site 1087454005560 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1087454005561 Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304 1087454005562 Histidine kinase; Region: HisKA_3; pfam07730 1087454005563 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1087454005564 ATP binding site [chemical binding]; other site 1087454005565 Mg2+ binding site [ion binding]; other site 1087454005566 G-X-G motif; other site 1087454005567 Domain of unknown function (DUF2020); Region: DUF2020; pfam09449 1087454005568 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 1087454005569 active site 1087454005570 catalytic site [active] 1087454005571 putative inner membrane protein translocase component YidC; Validated; Region: PRK00247 1087454005572 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1087454005573 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1087454005574 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1087454005575 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1087454005576 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1087454005577 Ligand Binding Site [chemical binding]; other site 1087454005578 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1087454005579 Ligand Binding Site [chemical binding]; other site 1087454005580 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1087454005581 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1087454005582 active site 1087454005583 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1087454005584 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1087454005585 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1087454005586 Walker A/P-loop; other site 1087454005587 ATP binding site [chemical binding]; other site 1087454005588 Q-loop/lid; other site 1087454005589 ABC transporter signature motif; other site 1087454005590 Walker B; other site 1087454005591 D-loop; other site 1087454005592 H-loop/switch region; other site 1087454005593 Predicted transcriptional regulators [Transcription]; Region: COG1725 1087454005594 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1087454005595 DNA-binding site [nucleotide binding]; DNA binding site 1087454005596 LabA_like proteins; Region: LabA_like; cd06167 1087454005597 putative metal binding site [ion binding]; other site 1087454005598 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1087454005599 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1087454005600 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1087454005601 catalytic residues [active] 1087454005602 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1087454005603 metal-binding site [ion binding] 1087454005604 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1087454005605 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1087454005606 metal-binding site [ion binding] 1087454005607 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1087454005608 benzoate transport; Region: 2A0115; TIGR00895 1087454005609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087454005610 putative substrate translocation pore; other site 1087454005611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1087454005612 replicative DNA helicase; Provisional; Region: PRK05636 1087454005613 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1087454005614 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1087454005615 Walker A motif; other site 1087454005616 ATP binding site [chemical binding]; other site 1087454005617 Walker B motif; other site 1087454005618 DNA binding loops [nucleotide binding] 1087454005619 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1087454005620 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1087454005621 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1087454005622 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1087454005623 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1087454005624 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1087454005625 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1087454005626 dimer interface [polypeptide binding]; other site 1087454005627 ssDNA binding site [nucleotide binding]; other site 1087454005628 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1087454005629 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1087454005630 Predicted integral membrane protein [Function unknown]; Region: COG5650 1087454005631 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1087454005632 Transglycosylase; Region: Transgly; pfam00912 1087454005633 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1087454005634 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1087454005635 MarR family; Region: MarR; pfam01047 1087454005636 MarR family; Region: MarR_2; cl17246 1087454005637 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1087454005638 Ligand Binding Site [chemical binding]; other site 1087454005639 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1087454005640 Ligand Binding Site [chemical binding]; other site 1087454005641 short chain dehydrogenase; Provisional; Region: PRK08219 1087454005642 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1087454005643 NAD(P) binding site [chemical binding]; other site 1087454005644 active site 1087454005645 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1087454005646 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1087454005647 active site residue [active] 1087454005648 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1087454005649 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1087454005650 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1087454005651 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1087454005652 dimerization interface [polypeptide binding]; other site 1087454005653 DPS ferroxidase diiron center [ion binding]; other site 1087454005654 ion pore; other site 1087454005655 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1087454005656 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1087454005657 putative DNA binding site [nucleotide binding]; other site 1087454005658 catalytic residue [active] 1087454005659 putative H2TH interface [polypeptide binding]; other site 1087454005660 putative catalytic residues [active] 1087454005661 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1087454005662 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1087454005663 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 1087454005664 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1087454005665 putative substrate binding site [chemical binding]; other site 1087454005666 putative ATP binding site [chemical binding]; other site 1087454005667 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 1087454005668 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1087454005669 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1087454005670 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1087454005671 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1087454005672 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1087454005673 HIGH motif; other site 1087454005674 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1087454005675 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1087454005676 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1087454005677 active site 1087454005678 KMSKS motif; other site 1087454005679 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1087454005680 tRNA binding surface [nucleotide binding]; other site 1087454005681 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1087454005682 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1087454005683 Walker A/P-loop; other site 1087454005684 ATP binding site [chemical binding]; other site 1087454005685 Q-loop/lid; other site 1087454005686 ABC transporter signature motif; other site 1087454005687 Walker B; other site 1087454005688 D-loop; other site 1087454005689 H-loop/switch region; other site 1087454005690 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1087454005691 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1087454005692 FtsX-like permease family; Region: FtsX; pfam02687 1087454005693 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1087454005694 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1087454005695 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1087454005696 Histidine kinase; Region: HisKA_3; pfam07730 1087454005697 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1087454005698 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1087454005699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1087454005700 active site 1087454005701 phosphorylation site [posttranslational modification] 1087454005702 intermolecular recognition site; other site 1087454005703 dimerization interface [polypeptide binding]; other site 1087454005704 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1087454005705 DNA binding residues [nucleotide binding] 1087454005706 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1087454005707 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1087454005708 active site 1087454005709 trimer interface [polypeptide binding]; other site 1087454005710 allosteric site; other site 1087454005711 active site lid [active] 1087454005712 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1087454005713 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1087454005714 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1087454005715 active site 1087454005716 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1087454005717 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1087454005718 putative active site cavity [active] 1087454005719 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1087454005720 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1087454005721 nucleotide binding site [chemical binding]; other site 1087454005722 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1087454005723 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1087454005724 DNA-binding site [nucleotide binding]; DNA binding site 1087454005725 FCD domain; Region: FCD; pfam07729 1087454005726 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1087454005727 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1087454005728 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1087454005729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087454005730 dimer interface [polypeptide binding]; other site 1087454005731 conserved gate region; other site 1087454005732 putative PBP binding loops; other site 1087454005733 ABC-ATPase subunit interface; other site 1087454005734 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1087454005735 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1087454005736 dimer interface [polypeptide binding]; other site 1087454005737 conserved gate region; other site 1087454005738 putative PBP binding loops; other site 1087454005739 ABC-ATPase subunit interface; other site 1087454005740 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1087454005741 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1087454005742 Walker A/P-loop; other site 1087454005743 ATP binding site [chemical binding]; other site 1087454005744 Q-loop/lid; other site 1087454005745 ABC transporter signature motif; other site 1087454005746 Walker B; other site 1087454005747 D-loop; other site 1087454005748 H-loop/switch region; other site 1087454005749 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1087454005750 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1087454005751 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1087454005752 Walker A/P-loop; other site 1087454005753 ATP binding site [chemical binding]; other site 1087454005754 Q-loop/lid; other site 1087454005755 ABC transporter signature motif; other site 1087454005756 Walker B; other site 1087454005757 D-loop; other site 1087454005758 H-loop/switch region; other site 1087454005759 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1087454005760 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1087454005761 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1087454005762 inhibitor site; inhibition site 1087454005763 active site 1087454005764 dimer interface [polypeptide binding]; other site 1087454005765 catalytic residue [active] 1087454005766 CAAX protease self-immunity; Region: Abi; pfam02517 1087454005767 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 1087454005768 hypothetical protein; Provisional; Region: PRK13663 1087454005769 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 1087454005770 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 1087454005771 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1087454005772 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1087454005773 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1087454005774 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1087454005775 substrate binding pocket [chemical binding]; other site 1087454005776 substrate-Mg2+ binding site; other site 1087454005777 aspartate-rich region 1; other site 1087454005778 aspartate-rich region 2; other site 1087454005779 SdpI/YhfL protein family; Region: SdpI; pfam13630 1087454005780 anthranilate synthase component I; Provisional; Region: PRK13564 1087454005781 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1087454005782 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1087454005783 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1087454005784 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1087454005785 glutamine binding [chemical binding]; other site 1087454005786 catalytic triad [active] 1087454005787 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1087454005788 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1087454005789 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1087454005790 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1087454005791 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1087454005792 active site 1087454005793 ribulose/triose binding site [chemical binding]; other site 1087454005794 phosphate binding site [ion binding]; other site 1087454005795 substrate (anthranilate) binding pocket [chemical binding]; other site 1087454005796 product (indole) binding pocket [chemical binding]; other site 1087454005797 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1087454005798 active site 1087454005799 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1087454005800 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1087454005801 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1087454005802 catalytic residue [active] 1087454005803 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1087454005804 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1087454005805 substrate binding site [chemical binding]; other site 1087454005806 active site 1087454005807 catalytic residues [active] 1087454005808 heterodimer interface [polypeptide binding]; other site 1087454005809 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1087454005810 iron-sulfur cluster [ion binding]; other site 1087454005811 [2Fe-2S] cluster binding site [ion binding]; other site 1087454005812 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1087454005813 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1087454005814 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1087454005815 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1087454005816 hypothetical protein; Validated; Region: PRK00228 1087454005817 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1087454005818 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1087454005819 active site 1087454005820 NTP binding site [chemical binding]; other site 1087454005821 metal binding triad [ion binding]; metal-binding site 1087454005822 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1087454005823 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1087454005824 Zn2+ binding site [ion binding]; other site 1087454005825 Mg2+ binding site [ion binding]; other site 1087454005826 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1087454005827 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1087454005828 active site 1087454005829 Ap6A binding site [chemical binding]; other site 1087454005830 nudix motif; other site 1087454005831 metal binding site [ion binding]; metal-binding site 1087454005832 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1087454005833 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1087454005834 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1087454005835 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1087454005836 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1087454005837 DNA binding residues [nucleotide binding] 1087454005838 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1087454005839 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1087454005840 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1087454005841 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1087454005842 catalytic residues [active] 1087454005843 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1087454005844 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1087454005845 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1087454005846 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1087454005847 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1087454005848 active site 1087454005849 metal binding site [ion binding]; metal-binding site 1087454005850 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1087454005851 ParB-like nuclease domain; Region: ParBc; pfam02195 1087454005852 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1087454005853 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1087454005854 P-loop; other site 1087454005855 Magnesium ion binding site [ion binding]; other site 1087454005856 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1087454005857 Magnesium ion binding site [ion binding]; other site 1087454005858 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1087454005859 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1087454005860 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 1087454005861 Haemolytic domain; Region: Haemolytic; pfam01809 1087454005862 ribonuclease P; Reviewed; Region: rnpA; PRK03459 1087454005863 Ribosomal protein L34; Region: Ribosomal_L34; cl00370